locus-tag	class	description
A6F53_RS00010	COG0438	transferase activity, transferring glycosyl groups
A6F53_RS00175	COG0582	viral genome integration into host DNA
A6F53_RS00195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6F53_RS00220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A6F53_RS00230	COG2244	polysaccharide biosynthetic process
A6F53_RS00235	COG1476	TRANSCRIPTIONal
A6F53_RS00240	COG1506	peptidase
A6F53_RS00240	COG0823	Involved in the tonB-independent uptake of proteins
A6F53_RS00240	COG4946	Tricorn protease homolog
A6F53_RS00245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6F53_RS00255	COG1393	Belongs to the ArsC family
A6F53_RS00260	COG0025	NhaP-type Na H and K H
A6F53_RS00265	COG0737	Belongs to the 5'-nucleotidase family
A6F53_RS00290	COG1609	Transcriptional regulator
A6F53_RS00305	COG4475	Protein of unknown function (DUF436)
A6F53_RS00315	COG0351	phosphomethylpyrimidine kinase
A6F53_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6F53_RS00325	COG1316	TRANSCRIPTIONal
A6F53_RS00340	COG0772	Belongs to the SEDS family
A6F53_RS00345	COG2814	Major facilitator Superfamily
A6F53_RS00350	COG1733	regulation of RNA biosynthetic process
A6F53_RS00375	COG1940	carbohydrate kinase activity
A6F53_RS00390	COG2076	Multidrug Resistance protein
A6F53_RS00395	COG2076	Multidrug Resistance protein
A6F53_RS00440	COG1518	maintenance of DNA repeat elements
A6F53_RS00445	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6F53_RS00450	COG4166	transmembrane transport
A6F53_RS00465	COG1609	Transcriptional regulator
A6F53_RS00475	COG0366	Alpha amylase catalytic
A6F53_RS00485	COG0604	alcohol dehydrogenase
A6F53_RS00515	COG1902	pentaerythritol trinitrate reductase activity
A6F53_RS00525	COG1733	regulation of RNA biosynthetic process
A6F53_RS00540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F53_RS00570	COG1881	PFAM PEBP family protein
A6F53_RS00585	COG0577	efflux transmembrane transporter activity
A6F53_RS00595	COG2814	Major facilitator Superfamily
A6F53_RS00620	COG3623	hexulose-6-phosphate isomerase
A6F53_RS00625	COG1070	Carbohydrate kinase
A6F53_RS00640	COG1609	Transcriptional regulator
A6F53_RS00655	COG0281	malic enzyme
A6F53_RS00660	COG0583	DNA-binding transcription factor activity
A6F53_RS00690	COG2957	Belongs to the agmatine deiminase family
A6F53_RS00695	COG0531	amino acid
A6F53_RS00700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F53_RS00705	COG1757	Na H antiporter
A6F53_RS00710	COG0531	amino acid
A6F53_RS00735	COG0183	Belongs to the thiolase family
A6F53_RS00765	COG2261	transglycosylase associated protein
A6F53_RS00775	COG2207	Transcriptional regulator
A6F53_RS00785	COG3022	response to hydroperoxide
A6F53_RS00790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6F53_RS00795	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F53_RS00800	COG2814	Major facilitator Superfamily
A6F53_RS00810	COG2267	carboxylic ester hydrolase activity
A6F53_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F53_RS00825	COG1397	ADP-ribosylglycohydrolase
A6F53_RS00830	COG2188	Transcriptional regulator
A6F53_RS00880	COG1917	Cupin 2, conserved barrel domain protein
A6F53_RS00880	COG4977	sequence-specific DNA binding
A6F53_RS00895	COG0110	maltose O-acetyltransferase activity
A6F53_RS00935	COG4932	domain protein
A6F53_RS00935	COG4886	Leucine-rich repeat (LRR) protein
A6F53_RS00945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6F53_RS00950	COG2814	Major facilitator Superfamily
A6F53_RS01020	COG3250	beta-galactosidase activity
A6F53_RS01025	COG1959	2 iron, 2 sulfur cluster binding
A6F53_RS01030	COG0702	epimerase
A6F53_RS01050	COG1917	Cupin 2, conserved barrel domain protein
A6F53_RS01050	COG4977	sequence-specific DNA binding
A6F53_RS01060	COG1074	ATP-dependent DNA helicase activity
A6F53_RS01065	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6F53_RS01070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F53_RS01075	COG0726	polysaccharide deacetylase
A6F53_RS01090	COG0667	Aldo Keto reductase
A6F53_RS01095	COG2252	PERMEase
A6F53_RS01110	COG1846	Transcriptional regulator
A6F53_RS01130	COG4485	Bacterial membrane protein, YfhO
A6F53_RS01160	COG2211	Major facilitator Superfamily
A6F53_RS01165	COG2207	Transcriptional regulator
A6F53_RS01225	COG2814	Major facilitator Superfamily
A6F53_RS01235	COG1607	acyl-coa hydrolase
A6F53_RS01240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6F53_RS01250	COG1114	Component of the transport system for branched-chain amino acids
A6F53_RS01260	COG1011	Hydrolase
A6F53_RS01270	COG0445	tRNA wobble uridine modification
A6F53_RS01275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F53_RS01285	COG0706	membrane insertase activity
A6F53_RS01290	COG0594	ribonuclease P activity
A6F53_RS01295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F53_RS01300	COG0592	DNA-directed DNA polymerase activity
A6F53_RS01305	COG2501	S4 domain
A6F53_RS01310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F53_RS01315	COG0187	DNA topoisomerase II activity
A6F53_RS01320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F53_RS01325	COG0360	Binds together with S18 to 16S ribosomal RNA
A6F53_RS01330	COG0629	single-stranded DNA binding
A6F53_RS01335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6F53_RS01345	COG4166	transmembrane transport
A6F53_RS01360	COG4166	transmembrane transport
A6F53_RS01380	COG0359	binds to the 23S rRNA
A6F53_RS01390	COG0305	Participates in initiation and elongation during chromosome replication
A6F53_RS01400	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6F53_RS01405	COG2814	Major facilitator Superfamily
A6F53_RS01415	COG4166	transmembrane transport
A6F53_RS01435	COG0745	RESPONSE REGULATOR receiver
A6F53_RS01455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6F53_RS01460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F53_RS01465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F53_RS01475	COG4886	Leucine-rich repeat (LRR) protein
A6F53_RS01475	COG4932	domain protein
A6F53_RS01495	COG0737	Belongs to the 5'-nucleotidase family
A6F53_RS01500	COG2153	protein acetylation
A6F53_RS01510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F53_RS01525	COG0791	NLP P60 protein
A6F53_RS01525	COG3883	PFAM NLP P60 protein
A6F53_RS01540	COG0488	(ABC) transporter
A6F53_RS01550	COG0477	Major facilitator Superfamily
A6F53_RS01560	COG1846	Transcriptional regulator
A6F53_RS01570	COG1397	ADP-ribosylglycohydrolase
A6F53_RS01575	COG0110	maltose O-acetyltransferase activity
A6F53_RS01600	COG4166	transmembrane transport
A6F53_RS01645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6F53_RS01670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6F53_RS01710	COG0531	amino acid
A6F53_RS01715	COG0076	glutamate decarboxylase activity
A6F53_RS01720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F53_RS01750	COG0450	alkyl hydroperoxide reductase
A6F53_RS01760	COG0702	epimerase
A6F53_RS01800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6F53_RS01825	COG2746	aminoglycoside 3-N-acetyltransferase activity
A6F53_RS01840	COG0667	Aldo Keto reductase
A6F53_RS01850	COG2814	Major facilitator Superfamily
A6F53_RS01860	COG2910	NAD(P)H-binding
A6F53_RS01865	COG0477	Major facilitator Superfamily
A6F53_RS01875	COG0778	Nitroreductase
A6F53_RS01885	COG0488	(ABC) transporter
A6F53_RS01890	COG0477	Major facilitator Superfamily
A6F53_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS01905	COG1609	Transcriptional regulator
A6F53_RS01910	COG1309	transcriptional regulator
A6F53_RS01915	COG0300	oxidoreductase activity
A6F53_RS01920	COG1253	flavin adenine dinucleotide binding
A6F53_RS01935	COG0531	amino acid
A6F53_RS01940	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
A6F53_RS01960	COG1454	alcohol dehydrogenase
A6F53_RS01965	COG0791	NLP P60 protein
A6F53_RS01965	COG1388	LysM domain
A6F53_RS01975	COG0791	NLP P60 protein
A6F53_RS01975	COG1388	LysM domain
A6F53_RS01990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6F53_RS01995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F53_RS02000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6F53_RS02015	COG1131	(ABC) transporter
A6F53_RS02020	COG1418	mRNA catabolic process
A6F53_RS02025	COG0534	Mate efflux family protein
A6F53_RS02030	COG1904	glucuronate isomerase
A6F53_RS02035	COG2211	Major facilitator Superfamily
A6F53_RS02045	COG3250	beta-galactosidase activity
A6F53_RS02050	COG0246	Mannitol dehydrogenase
A6F53_RS02060	COG0588	phosphoglycerate mutase activity
A6F53_RS02065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F53_RS02070	COG1070	Carbohydrate kinase
A6F53_RS02075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6F53_RS02085	COG1312	Catalyzes the dehydration of D-mannonate
A6F53_RS02090	COG1609	Transcriptional regulator
A6F53_RS02095	COG2211	Major facilitator Superfamily
A6F53_RS02105	COG1904	glucuronate isomerase
A6F53_RS02120	COG0477	Major facilitator Superfamily
A6F53_RS02145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6F53_RS02150	COG2188	Transcriptional regulator
A6F53_RS02160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F53_RS02190	COG0564	pseudouridine synthase activity
A6F53_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6F53_RS02225	COG0601	transmembrane transport
A6F53_RS02230	COG4608	Belongs to the ABC transporter superfamily
A6F53_RS02245	COG0095	Lipoate-protein ligase
A6F53_RS02265	COG2115	Belongs to the xylose isomerase family
A6F53_RS02285	COG5646	InterPro IPR014922
A6F53_RS02300	COG1881	PFAM PEBP family protein
A6F53_RS02320	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS02335	COG1757	Na H antiporter
A6F53_RS02345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F53_RS02350	COG3290	protein histidine kinase activity
A6F53_RS02355	COG4565	transcriptional regulatory protein
A6F53_RS02365	COG1309	transcriptional regulator
A6F53_RS02400	COG3479	Phenolic acid decarboxylase
A6F53_RS02405	COG1695	Transcriptional regulator
A6F53_RS02420	COG2153	protein acetylation
A6F53_RS02425	COG1846	Transcriptional regulator
A6F53_RS02460	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F53_RS02470	COG0516	GMP reductase activity
A6F53_RS02475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6F53_RS02480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F53_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
A6F53_RS02500	COG1309	transcriptional regulator
A6F53_RS02510	COG2365	Tyrosine phosphatase family
A6F53_RS02530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6F53_RS02560	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F53_RS02565	COG1917	Cupin 2, conserved barrel domain protein
A6F53_RS02565	COG2207	Transcriptional regulator
A6F53_RS02575	COG2211	Major facilitator Superfamily
A6F53_RS02585	COG1335	isochorismatase
A6F53_RS02605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F53_RS02610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F53_RS02615	COG0716	FMN binding
A6F53_RS02625	COG1113	amino acid transport
A6F53_RS02650	COG1064	alcohol dehydrogenase
A6F53_RS02660	COG0517	IMP dehydrogenase activity
A6F53_RS02660	COG1125	glycine betaine transport
A6F53_RS02670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6F53_RS02685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6F53_RS02705	COG0110	maltose O-acetyltransferase activity
A6F53_RS02730	COG1686	Belongs to the peptidase S11 family
A6F53_RS02735	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS02740	COG2217	Heavy metal translocating P-type atpase
A6F53_RS02750	COG0726	polysaccharide deacetylase
A6F53_RS02760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6F53_RS02765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6F53_RS02765	COG2755	lipolytic protein G-D-S-L family
A6F53_RS02815	COG1942	4-Oxalocrotonate Tautomerase
A6F53_RS02830	COG1174	glycine betaine transport
A6F53_RS02835	COG1732	Glycine betaine
A6F53_RS02860	COG2837	iron assimilation
A6F53_RS02880	COG0463	Glycosyl transferase, family 2
A6F53_RS02895	COG0628	permease
A6F53_RS02900	COG0577	efflux transmembrane transporter activity
A6F53_RS02905	COG1136	(ABC) transporter
A6F53_RS02910	COG0366	Alpha amylase catalytic
A6F53_RS02930	COG0028	Belongs to the TPP enzyme family
A6F53_RS02945	COG5002	protein histidine kinase activity
A6F53_RS02950	COG0745	RESPONSE REGULATOR receiver
A6F53_RS02960	COG0702	epimerase
A6F53_RS02965	COG1252	NADH dehydrogenase
A6F53_RS02970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F53_RS02980	COG1012	belongs to the aldehyde dehydrogenase family
A6F53_RS02985	COG1414	Transcriptional regulator
A6F53_RS03000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6F53_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS03015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F53_RS03035	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F53_RS03045	COG1307	EDD domain protein, DegV family
A6F53_RS03050	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F53_RS03055	COG3118	belongs to the thioredoxin family
A6F53_RS03060	COG1937	Protein conserved in bacteria
A6F53_RS03065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F53_RS03070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F53_RS03080	COG0657	acetylesterase activity
A6F53_RS03085	COG1854	S-ribosylhomocysteine lyase activity
A6F53_RS03095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6F53_RS03105	COG0583	DNA-binding transcription factor activity
A6F53_RS03130	COG2357	RelA SpoT domain protein
A6F53_RS03155	COG0745	RESPONSE REGULATOR receiver
A6F53_RS03160	COG5002	protein histidine kinase activity
A6F53_RS03165	COG1609	Transcriptional regulator
A6F53_RS03185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6F53_RS03190	COG2017	converts alpha-aldose to the beta-anomer
A6F53_RS03200	COG0561	phosphatase activity
A6F53_RS03215	COG1393	Belongs to the ArsC family
A6F53_RS03220	COG3103	Sh3 type 3 domain protein
A6F53_RS03220	COG1388	LysM domain
A6F53_RS03220	COG0791	NLP P60 protein
A6F53_RS03235	COG0730	response to heat
A6F53_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS03255	COG2207	Transcriptional regulator
A6F53_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS03270	COG1959	2 iron, 2 sulfur cluster binding
A6F53_RS03275	COG0463	Glycosyl transferase, family 2
A6F53_RS03275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6F53_RS03285	COG1733	regulation of RNA biosynthetic process
A6F53_RS03290	COG2814	Major facilitator Superfamily
A6F53_RS03295	COG4989	oxidoreductase activity
A6F53_RS03300	COG1136	(ABC) transporter
A6F53_RS03325	COG2217	Heavy metal translocating P-type atpase
A6F53_RS03340	COG2132	Multicopper oxidase
A6F53_RS03355	COG2855	membrane
A6F53_RS03360	COG0583	DNA-binding transcription factor activity
A6F53_RS03365	COG2814	Major facilitator Superfamily
A6F53_RS03375	COG0488	(ABC) transporter
A6F53_RS03405	COG3052	prosthetic group binding
A6F53_RS03425	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A6F53_RS03460	COG1725	Transcriptional regulator
A6F53_RS03465	COG1131	(ABC) transporter
A6F53_RS03475	COG3835	regulator
A6F53_RS03480	COG2610	gluconate transmembrane transporter activity
A6F53_RS03485	COG1929	Belongs to the glycerate kinase type-1 family
A6F53_RS03495	COG3428	Bacterial PH domain
A6F53_RS03540	COG1914	H( )-stimulated, divalent metal cation uptake system
A6F53_RS03550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F53_RS03575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6F53_RS03580	COG2323	membrane
A6F53_RS03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F53_RS03650	COG1609	Transcriptional regulator
A6F53_RS03665	COG3973	AAA domain
A6F53_RS03675	COG0248	Ppx GppA phosphatase
A6F53_RS03690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6F53_RS03700	COG1801	Protein of unknown function DUF72
A6F53_RS03705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F53_RS03705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F53_RS03710	COG0084	hydrolase, TatD family'
A6F53_RS03715	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A6F53_RS03720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F53_RS03725	COG4466	Protein conserved in bacteria
A6F53_RS03730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F53_RS03735	COG1573	uracil-dna glycosylase
A6F53_RS03755	COG2723	6-phospho-beta-galactosidase activity
A6F53_RS03760	COG1940	carbohydrate kinase activity
A6F53_RS03785	COG3279	Response regulator of the LytR AlgR family
A6F53_RS03800	COG1121	(ABC) transporter
A6F53_RS03805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6F53_RS03815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F53_RS03820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6F53_RS03825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6F53_RS03840	COG2188	Transcriptional regulator
A6F53_RS03845	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A6F53_RS03850	COG0561	phosphatase activity
A6F53_RS03855	COG1078	dGTPase activity
A6F53_RS03860	COG0095	Lipoate-protein ligase
A6F53_RS03870	COG3343	RNA polymerase activity
A6F53_RS03875	COG0504	CTP synthase activity
A6F53_RS03895	COG0028	Belongs to the TPP enzyme family
A6F53_RS03900	COG3527	Alpha-acetolactate decarboxylase
A6F53_RS03910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F53_RS03915	COG0254	rRNA binding
A6F53_RS03920	COG3764	Sortase (surface protein transpeptidase)
A6F53_RS03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F53_RS03980	COG1704	LemA family
A6F53_RS03985	COG0501	Belongs to the peptidase M48B family
A6F53_RS03995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F53_RS04010	COG0736	holo-[acyl-carrier-protein] synthase activity
A6F53_RS04015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6F53_RS04025	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6F53_RS04045	COG0193	aminoacyl-tRNA hydrolase activity
A6F53_RS04050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F53_RS04055	COG2244	polysaccharide biosynthetic process
A6F53_RS04060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6F53_RS04070	COG1098	S1 RNA binding domain
A6F53_RS04075	COG0037	tRNA processing
A6F53_RS04090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F53_RS04095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6F53_RS04130	COG3104	oligopeptide transport
A6F53_RS04150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F53_RS04155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6F53_RS04160	COG2188	Transcriptional regulator
A6F53_RS04175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6F53_RS04180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F53_RS04190	COG2183	response to ionizing radiation
A6F53_RS04195	COG3091	SprT-like family
A6F53_RS04200	COG0083	homoserine kinase activity
A6F53_RS04240	COG0534	Mate efflux family protein
A6F53_RS04255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6F53_RS04255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F53_RS04260	COG3715	PTS system
A6F53_RS04265	COG3716	PTS system mannose fructose sorbose family IID component
A6F53_RS04270	COG0628	permease
A6F53_RS04290	COG1511	domain protein
A6F53_RS04295	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6F53_RS04300	COG1316	TRANSCRIPTIONal
A6F53_RS04310	COG0697	spore germination
A6F53_RS04315	COG0588	phosphoglycerate mutase activity
A6F53_RS04330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6F53_RS04340	COG0756	dUTP diphosphatase activity
A6F53_RS04350	COG4956	integral membrane protein (PIN domain superfamily)
A6F53_RS04355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F53_RS04360	COG0215	cysteine-tRNA ligase activity
A6F53_RS04365	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6F53_RS04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F53_RS04375	COG3688	RNA-binding protein containing a PIN domain
A6F53_RS04390	COG0250	Participates in transcription elongation, termination and antitermination
A6F53_RS04395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F53_RS04400	COG0081	regulation of translation
A6F53_RS04405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F53_RS04410	COG0222	ribosome binding
A6F53_RS04415	COG0745	RESPONSE REGULATOR receiver
A6F53_RS04420	COG5002	protein histidine kinase activity
A6F53_RS04425	COG0463	Glycosyl transferase, family 2
A6F53_RS04440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6F53_RS04440	COG0392	lysyltransferase activity
A6F53_RS04450	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F53_RS04455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F53_RS04465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F53_RS04470	COG2813	Specifically methylates the guanine in position
A6F53_RS04485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6F53_RS04490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6F53_RS04495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F53_RS04505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6F53_RS04510	COG3870	Protein conserved in bacteria
A6F53_RS04515	COG0470	DNA polymerase III
A6F53_RS04520	COG4467	Involved in initiation control of chromosome replication
A6F53_RS04535	COG1214	PFAM Peptidase M22, glycoprotease
A6F53_RS04545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6F53_RS04550	COG2807	transmembrane transport
A6F53_RS04555	COG0640	Transcriptional regulator
A6F53_RS04560	COG0488	(ABC) transporter
A6F53_RS04565	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6F53_RS04570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6F53_RS04575	COG0459	protein refolding
A6F53_RS04580	COG0531	amino acid
A6F53_RS04585	COG1346	cytolysis
A6F53_RS04595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F53_RS04600	COG1739	Uncharacterized protein family UPF0029
A6F53_RS04605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6F53_RS04620	COG0653	protein targeting
A6F53_RS04625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6F53_RS04635	COG0745	RESPONSE REGULATOR receiver
A6F53_RS04640	COG5002	protein histidine kinase activity
A6F53_RS04650	COG0573	inorganic phosphate transmembrane transporter activity
A6F53_RS04655	COG0581	inorganic phosphate transmembrane transporter activity
A6F53_RS04660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F53_RS04665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F53_RS04670	COG0704	Plays a role in the regulation of phosphate uptake
A6F53_RS04675	COG1983	PspC domain protein
A6F53_RS04685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6F53_RS04690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F53_RS04695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6F53_RS04700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6F53_RS04705	COG0492	ferredoxin-NADP+ reductase activity
A6F53_RS04720	COG0556	nucleotide-excision repair
A6F53_RS04725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F53_RS04735	COG1660	Displays ATPase and GTPase activities
A6F53_RS04740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6F53_RS04745	COG1481	regulation of sporulation
A6F53_RS04750	COG0740	serine-type endopeptidase activity
A6F53_RS04770	COG4684	Psort location CytoplasmicMembrane, score
A6F53_RS04790	COG0126	phosphoglycerate kinase activity
A6F53_RS04795	COG0149	triose-phosphate isomerase activity
A6F53_RS04800	COG0148	phosphopyruvate hydratase activity
A6F53_RS04815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F53_RS04825	COG0557	exoribonuclease II activity
A6F53_RS04830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6F53_RS04845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6F53_RS04850	COG0280	phosphate acetyltransferase
A6F53_RS04855	COG0802	atpase or kinase
A6F53_RS04865	COG0667	Aldo Keto reductase
A6F53_RS04875	COG0708	Exodeoxyribonuclease III
A6F53_RS04880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F53_RS04885	COG0025	NhaP-type Na H and K H
A6F53_RS04895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6F53_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F53_RS04910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F53_RS04915	COG0363	glucosamine-6-phosphate deaminase activity
A6F53_RS04920	COG1388	LysM domain
A6F53_RS04920	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6F53_RS04945	COG1134	teichoic acid transport
A6F53_RS04980	COG1120	ATPase activity
A6F53_RS04985	COG0248	Ppx GppA phosphatase
A6F53_RS04990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F53_RS05000	COG3475	LICD family
A6F53_RS05025	COG3759	membrane
A6F53_RS05035	COG0114	fumarate hydratase activity
A6F53_RS05045	COG1609	Transcriptional regulator
A6F53_RS05065	COG2235	arginine
A6F53_RS05085	COG0745	RESPONSE REGULATOR receiver
A6F53_RS05090	COG3850	Histidine kinase
A6F53_RS05090	COG5002	protein histidine kinase activity
A6F53_RS05095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6F53_RS05100	COG4975	Glucose uptake
A6F53_RS05105	COG0166	Belongs to the GPI family
A6F53_RS05115	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6F53_RS05135	COG4974	Belongs to the 'phage' integrase family
A6F53_RS05200	COG4695	Portal protein
A6F53_RS05235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6F53_RS05240	COG2203	Gaf domain
A6F53_RS05240	COG3706	GGDEF domain
A6F53_RS05240	COG4251	negative regulation of phosphorylation
A6F53_RS05240	COG5001	Diguanylate cyclase
A6F53_RS05275	COG3442	glutamine amidotransferase
A6F53_RS05280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F53_RS05285	COG1435	thymidine kinase activity
A6F53_RS05290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6F53_RS05295	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F53_RS05300	COG0009	L-threonylcarbamoyladenylate synthase
A6F53_RS05305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F53_RS05310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6F53_RS05315	COG0356	it plays a direct role in the translocation of protons across the membrane
A6F53_RS05320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F53_RS05325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F53_RS05330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F53_RS05335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6F53_RS05340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6F53_RS05345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6F53_RS05350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F53_RS05360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F53_RS05365	COG1077	Cell shape determining protein MreB Mrl
A6F53_RS05370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6F53_RS05380	COG0772	Belongs to the SEDS family
A6F53_RS05385	COG0509	glycine decarboxylation via glycine cleavage system
A6F53_RS05400	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F53_RS05415	COG0589	response to stress
A6F53_RS05425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F53_RS05435	COG4493	Belongs to the UPF0637 family
A6F53_RS05445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F53_RS05450	COG1956	GAF domain-containing protein
A6F53_RS05455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6F53_RS05460	COG1104	cysteine desulfurase activity
A6F53_RS05465	COG0301	tRNA thio-modification
A6F53_RS05475	COG0525	valine-tRNA ligase activity
A6F53_RS05480	COG0285	dihydrofolate synthase activity
A6F53_RS05485	COG2003	Belongs to the UPF0758 family
A6F53_RS05490	COG1077	Cell shape determining protein MreB Mrl
A6F53_RS05495	COG1792	Involved in formation and maintenance of cell shape
A6F53_RS05505	COG0850	regulation of cytokinetic process
A6F53_RS05510	COG2894	cell division
A6F53_RS05515	COG0765	amino acid transport
A6F53_RS05520	COG1126	abc transporter atp-binding protein
A6F53_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F53_RS05530	COG0612	Peptidase, M16
A6F53_RS05535	COG0612	Peptidase, M16
A6F53_RS05540	COG1426	Protein conserved in bacteria
A6F53_RS05545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F53_RS05550	COG1058	Belongs to the CinA family
A6F53_RS05550	COG1546	Belongs to the CinA family
A6F53_RS05555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F53_RS05560	COG1418	mRNA catabolic process
A6F53_RS05565	COG1692	metallophosphoesterase
A6F53_RS05570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F53_RS05575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6F53_RS05580	COG0632	four-way junction helicase activity
A6F53_RS05585	COG2255	four-way junction helicase activity
A6F53_RS05590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6F53_RS05595	COG0343	queuine tRNA-ribosyltransferase activity
A6F53_RS05600	COG1862	Preprotein translocase
A6F53_RS05605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6F53_RS05610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6F53_RS05615	COG0513	Belongs to the DEAD box helicase family
A6F53_RS05620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F53_RS05625	COG4472	Bacterial protein of unknown function (DUF965)
A6F53_RS05630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F53_RS05635	COG3906	Belongs to the UPF0473 family
A6F53_RS05650	COG1193	negative regulation of DNA recombination
A6F53_RS05655	COG3118	belongs to the thioredoxin family
A6F53_RS05660	COG1719	4-vinyl reductase, 4VR
A6F53_RS05665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6F53_RS05670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6F53_RS05680	COG0517	IMP dehydrogenase activity
A6F53_RS05685	COG0640	Transcriptional regulator
A6F53_RS05690	COG0477	Major facilitator Superfamily
A6F53_RS05695	COG0668	transmembrane transport
A6F53_RS05710	COG0006	proline dipeptidase activity
A6F53_RS05715	COG1609	Transcriptional regulator
A6F53_RS05725	COG1126	abc transporter atp-binding protein
A6F53_RS05730	COG0765	amino acid transport
A6F53_RS05735	COG0217	transcriptional regulatory protein
A6F53_RS05740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6F53_RS05750	COG4537	Required for transformation and DNA binding
A6F53_RS05770	COG0827	DNA restriction-modification system
A6F53_RS05780	COG1113	amino acid transport
A6F53_RS05785	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS05795	COG0737	Belongs to the 5'-nucleotidase family
A6F53_RS05800	COG4470	Protein conserved in bacteria
A6F53_RS05805	COG0647	UMP catabolic process
A6F53_RS05830	COG0531	amino acid
A6F53_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS05840	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS05845	COG0300	oxidoreductase activity
A6F53_RS05850	COG0789	Transcriptional regulator
A6F53_RS05855	COG0586	Pfam SNARE associated Golgi protein
A6F53_RS05860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6F53_RS05865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F53_RS05870	COG0539	negative regulation of cytoplasmic translation
A6F53_RS05990	COG1234	tRNA 3'-trailer cleavage
A6F53_RS05995	COG1393	Belongs to the ArsC family
A6F53_RS06000	COG4862	establishment of competence for transformation
A6F53_RS06015	COG1215	transferase activity, transferring glycosyl groups
A6F53_RS06025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6F53_RS06030	COG0671	phosphoesterase, PA-phosphatase related
A6F53_RS06035	COG0495	leucyl-tRNA aminoacylation
A6F53_RS06045	COG1129	ABC transporter
A6F53_RS06060	COG2244	polysaccharide biosynthetic process
A6F53_RS06065	COG1187	pseudouridine synthase activity
A6F53_RS06070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6F53_RS06080	COG0589	response to stress
A6F53_RS06090	COG1113	amino acid transport
A6F53_RS06100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F53_RS06105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F53_RS06110	COG1674	ftsk spoiiie
A6F53_RS06115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F53_RS06135	COG0402	S-adenosylhomocysteine deaminase activity
A6F53_RS06140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F53_RS06140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F53_RS06145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6F53_RS06150	COG0237	dephospho-CoA kinase activity
A6F53_RS06155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F53_RS06165	COG1484	DNA-dependent DNA replication
A6F53_RS06170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6F53_RS06175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F53_RS06180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6F53_RS06185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6F53_RS06195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6F53_RS06200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6F53_RS06210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F53_RS06215	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6F53_RS06220	COG0799	negative regulation of ribosome biogenesis
A6F53_RS06225	COG2226	methyltransferase
A6F53_RS06230	COG1323	Belongs to the UPF0348 family
A6F53_RS06240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6F53_RS06245	COG0561	phosphatase activity
A6F53_RS06250	COG0640	Transcriptional regulator
A6F53_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F53_RS06255	COG5549	protein import
A6F53_RS06260	COG1064	alcohol dehydrogenase
A6F53_RS06265	COG0745	RESPONSE REGULATOR receiver
A6F53_RS06270	COG5002	protein histidine kinase activity
A6F53_RS06280	COG0706	membrane insertase activity
A6F53_RS06285	COG1254	Belongs to the acylphosphatase family
A6F53_RS06290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F53_RS06300	COG1733	regulation of RNA biosynthetic process
A6F53_RS06305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6F53_RS06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F53_RS06310	COG0072	phenylalanine-tRNA ligase activity
A6F53_RS06315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F53_RS06320	COG0572	uridine kinase
A6F53_RS06325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F53_RS06340	COG2155	Conserved Protein
A6F53_RS06345	COG0768	penicillin binding
A6F53_RS06350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F53_RS06355	COG0457	Tetratricopeptide repeat
A6F53_RS06355	COG0705	Rhomboid family
A6F53_RS06365	COG1940	carbohydrate kinase activity
A6F53_RS06380	COG0584	glycerophosphoryl diester phosphodiesterase
A6F53_RS06385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F53_RS06390	COG0789	Transcriptional regulator
A6F53_RS06420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F53_RS06425	COG2868	ribosomal protein
A6F53_RS06430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6F53_RS06435	COG0006	proline dipeptidase activity
A6F53_RS06440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F53_RS06445	COG1302	Protein conserved in bacteria
A6F53_RS06450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F53_RS06455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F53_RS06460	COG1570	exodeoxyribonuclease VII activity
A6F53_RS06465	COG1722	exodeoxyribonuclease VII activity
A6F53_RS06475	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6F53_RS06480	COG1438	arginine binding
A6F53_RS06485	COG0497	DNA recombination
A6F53_RS06500	COG0194	GDP metabolic process
A6F53_RS06505	COG1758	RNA polymerase activity
A6F53_RS06510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F53_RS06515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6F53_RS06520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6F53_RS06525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F53_RS06525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F53_RS06530	COG0631	protein serine/threonine phosphatase activity
A6F53_RS06535	COG0515	serine threonine protein kinase
A6F53_RS06535	COG2815	serine threonine protein kinase
A6F53_RS06540	COG1162	GTPase activity
A6F53_RS06545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6F53_RS06550	COG1564	THIamine pyrophosphokinase
A6F53_RS06555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6F53_RS06560	COG1302	Protein conserved in bacteria
A6F53_RS06565	COG1461	Dihydroxyacetone kinase
A6F53_RS06570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F53_RS06575	COG0416	fatty acid biosynthetic process
A6F53_RS06580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F53_RS06585	COG0571	ribonuclease III activity
A6F53_RS06590	COG1196	nuclear chromosome segregation
A6F53_RS06595	COG0552	protein localization to endoplasmic reticulum
A6F53_RS06600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6F53_RS06605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F53_RS06630	COG0228	four-way junction DNA binding
A6F53_RS06635	COG1837	Belongs to the UPF0109 family
A6F53_RS06640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F53_RS06645	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F53_RS06650	COG0335	large ribosomal subunit rRNA binding
A6F53_RS06660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F53_RS06670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F53_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F53_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS06695	COG0511	ligase activity, forming carbon-carbon bonds
A6F53_RS06700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F53_RS06705	COG0439	Biotin carboxylase
A6F53_RS06710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6F53_RS06715	COG0825	malonyl-CoA metabolic process
A6F53_RS06720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F53_RS06730	COG1268	BioY protein
A6F53_RS06735	COG1694	Mazg nucleotide pyrophosphohydrolase
A6F53_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS06750	COG0789	Transcriptional regulator
A6F53_RS06760	COG2814	Major facilitator Superfamily
A6F53_RS06785	COG2814	Major facilitator Superfamily
A6F53_RS06790	COG1598	PFAM Uncharacterised protein family UPF0150
A6F53_RS06795	COG0789	Transcriptional regulator
A6F53_RS06800	COG0667	Aldo Keto reductase
A6F53_RS06810	COG1214	PFAM Peptidase M22, glycoprotease
A6F53_RS06810	COG0456	acetyltransferase
A6F53_RS06830	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F53_RS06855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6F53_RS06860	COG1942	4-Oxalocrotonate Tautomerase
A6F53_RS06865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6F53_RS06875	COG3655	Transcriptional regulator
A6F53_RS06890	COG1215	transferase activity, transferring glycosyl groups
A6F53_RS06905	COG0577	efflux transmembrane transporter activity
A6F53_RS06905	COG1136	(ABC) transporter
A6F53_RS06915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F53_RS06950	COG1309	transcriptional regulator
A6F53_RS06955	COG1304	FMN binding
A6F53_RS06965	COG0025	NhaP-type Na H and K H
A6F53_RS06970	COG2807	transmembrane transport
A6F53_RS06975	COG3158	transport of potassium into the cell
A6F53_RS06990	COG0789	Transcriptional regulator
A6F53_RS07010	COG0583	DNA-binding transcription factor activity
A6F53_RS07030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F53_RS07040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F53_RS07040	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6F53_RS07045	COG1304	FMN binding
A6F53_RS07065	COG1199	ATP-dependent helicase activity
A6F53_RS07065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F53_RS07085	COG0561	phosphatase activity
A6F53_RS07090	COG1609	Transcriptional regulator
A6F53_RS07095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F53_RS07100	COG3331	DNA recombination
A6F53_RS07105	COG4474	Belongs to the UPF0398 family
A6F53_RS07110	COG3599	regulation of cell shape
A6F53_RS07120	COG0116	Belongs to the methyltransferase superfamily
A6F53_RS07130	COG0004	ammonium transporteR
A6F53_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6F53_RS07180	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6F53_RS07185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6F53_RS07190	COG0564	pseudouridine synthase activity
A6F53_RS07195	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6F53_RS07210	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6F53_RS07215	COG1846	Transcriptional regulator
A6F53_RS07225	COG2270	Major facilitator Superfamily
A6F53_RS07230	COG1307	EDD domain protein, DegV family
A6F53_RS07235	COG4720	Psort location CytoplasmicMembrane, score
A6F53_RS07240	COG2246	polysaccharide biosynthetic process
A6F53_RS07255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F53_RS07310	COG4221	oxidoreductase activity
A6F53_RS07315	COG0789	Transcriptional regulator
A6F53_RS07325	COG4221	oxidoreductase activity
A6F53_RS07330	COG0583	DNA-binding transcription factor activity
A6F53_RS07335	COG0583	DNA-binding transcription factor activity
A6F53_RS07340	COG4221	oxidoreductase activity
A6F53_RS07365	COG1309	transcriptional regulator
A6F53_RS07370	COG0210	DNA helicase
A6F53_RS07380	COG4974	Belongs to the 'phage' integrase family
A6F53_RS07395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F53_RS07405	COG1227	inorganic diphosphatase activity
A6F53_RS07410	COG0583	DNA-binding transcription factor activity
A6F53_RS07420	COG0187	DNA topoisomerase II activity
A6F53_RS07425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F53_RS07435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6F53_RS07440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F53_RS07450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F53_RS07455	COG0758	DNA mediated transformation
A6F53_RS07460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6F53_RS07465	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6F53_RS07470	COG2816	NAD+ diphosphatase activity
A6F53_RS07485	COG1070	Carbohydrate kinase
A6F53_RS07500	COG4479	Belongs to the UPF0346 family
A6F53_RS07510	COG2755	lipolytic protein G-D-S-L family
A6F53_RS07515	COG1307	EDD domain protein, DegV family
A6F53_RS07520	COG1272	protein, Hemolysin III
A6F53_RS07525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6F53_RS07530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F53_RS07535	COG0488	(ABC) transporter
A6F53_RS07540	COG0617	tRNA 3'-terminal CCA addition
A6F53_RS07545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6F53_RS07550	COG0457	Tetratricopeptide repeat
A6F53_RS07560	COG1160	GTP binding
A6F53_RS07565	COG0539	negative regulation of cytoplasmic translation
A6F53_RS07570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F53_RS07575	COG1388	LysM domain
A6F53_RS07575	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6F53_RS07580	COG0514	ATP-dependent DNA helicase (RecQ)
A6F53_RS07590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6F53_RS07595	COG1187	pseudouridine synthase activity
A6F53_RS07600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F53_RS07605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F53_RS07620	COG2996	Protein conserved in bacteria
A6F53_RS07635	COG0587	DNA-directed DNA polymerase activity
A6F53_RS07640	COG0542	response to heat
A6F53_RS07650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6F53_RS07655	COG2384	SAM-dependent methyltransferase
A6F53_RS07660	COG1033	growth of symbiont in host cell
A6F53_RS07660	COG2409	Drug exporters of the RND superfamily
A6F53_RS07665	COG1959	2 iron, 2 sulfur cluster binding
A6F53_RS07670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F53_RS07675	COG0358	DNA primase activity
A6F53_RS07680	COG0751	glycine-tRNA ligase activity
A6F53_RS07685	COG0752	glycyl-tRNA synthetase alpha subunit
A6F53_RS07690	COG1381	Involved in DNA repair and RecF pathway recombination
A6F53_RS07695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6F53_RS07700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6F53_RS07705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6F53_RS07710	COG1702	phosphate starvation-inducible protein PhoH
A6F53_RS07715	COG1610	YqeY-like protein
A6F53_RS07720	COG1733	regulation of RNA biosynthetic process
A6F53_RS07730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6F53_RS07735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6F53_RS07740	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6F53_RS07745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6F53_RS07750	COG1682	transport, permease protein
A6F53_RS07760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6F53_RS07765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F53_RS07770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F53_RS07775	COG0124	histidyl-tRNA synthetase
A6F53_RS07785	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6F53_RS07790	COG3001	Fructosamine kinase
A6F53_RS07800	COG1490	D-aminoacyl-tRNA deacylase activity
A6F53_RS07805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6F53_RS07815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F53_RS07820	COG2264	protein methyltransferase activity
A6F53_RS07830	COG1970	mechanosensitive ion channel activity
A6F53_RS07855	COG1302	Protein conserved in bacteria
A6F53_RS07860	COG1302	Protein conserved in bacteria
A6F53_RS07875	COG2261	transglycosylase associated protein
A6F53_RS08050	COG0589	response to stress
A6F53_RS08085	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A6F53_RS08145	COG1396	sequence-specific DNA binding
A6F53_RS08205	COG0582	viral genome integration into host DNA
A6F53_RS08210	COG0481	GTPase activity
A6F53_RS08215	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6F53_RS08220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F53_RS08225	COG1696	Membrane protein involved in D-alanine export
A6F53_RS08230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6F53_RS08240	COG0484	heat shock protein binding
A6F53_RS08245	COG0443	Heat shock 70 kDa protein
A6F53_RS08250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F53_RS08255	COG1420	regulation of RNA biosynthetic process
A6F53_RS08260	COG0196	riboflavin kinase activity
A6F53_RS08265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F53_RS08270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6F53_RS08275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6F53_RS08285	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6F53_RS08290	COG0195	Participates in both transcription termination and antitermination
A6F53_RS08295	COG0779	Required for maturation of 30S ribosomal subunits
A6F53_RS08305	COG2176	DNA-directed DNA polymerase activity
A6F53_RS08310	COG0442	prolyl-tRNA aminoacylation
A6F53_RS08315	COG0750	zinc metalloprotease
A6F53_RS08320	COG4589	Belongs to the CDS family
A6F53_RS08325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F53_RS08340	COG0528	UMP kinase activity
A6F53_RS08345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6F53_RS08350	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F53_RS08360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F53_RS08365	COG2827	Endonuclease containing a URI domain
A6F53_RS08370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6F53_RS08375	COG0204	Acyl-transferase
A6F53_RS08380	COG1132	(ABC) transporter
A6F53_RS08385	COG1132	(ABC) transporter
A6F53_RS08390	COG3763	UPF0154 protein
A6F53_RS08395	COG4224	UPF0291 protein
A6F53_RS08400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6F53_RS08415	COG3425	synthase
A6F53_RS08420	COG2326	polyphosphate kinase activity
A6F53_RS08435	COG0105	UTP biosynthetic process
A6F53_RS08470	COG1597	lipid kinase activity
A6F53_RS08485	COG0589	response to stress
A6F53_RS08490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F53_RS08495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6F53_RS08495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6F53_RS08500	COG5416	Lipopolysaccharide assembly protein A domain
A6F53_RS08505	COG1234	tRNA 3'-trailer cleavage
A6F53_RS08520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6F53_RS08525	COG0322	excinuclease ABC activity
A6F53_RS08540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6F53_RS08545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F53_RS08550	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F53_RS08555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6F53_RS08570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6F53_RS08575	COG0268	Binds directly to 16S ribosomal RNA
A6F53_RS08585	COG1309	transcriptional regulator
A6F53_RS08590	COG1466	dna polymerase III delta subunit
A6F53_RS08595	COG0658	competence protein
A6F53_RS08595	COG2333	competence protein COMEC
A6F53_RS08600	COG2131	deaminase
A6F53_RS08610	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6F53_RS08615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6F53_RS08620	COG0742	ribosomal rna small subunit methyltransferase
A6F53_RS08625	COG4471	UPF0298 protein
A6F53_RS08630	COG0772	Belongs to the SEDS family
A6F53_RS08635	COG1217	gtp-binding protein TYPA
A6F53_RS08640	COG0483	inositol monophosphate 1-phosphatase activity
A6F53_RS08645	COG4476	Belongs to the UPF0223 family
A6F53_RS08670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F53_RS08675	COG0242	peptide deformylase activity
A6F53_RS08685	COG5503	Protein of unknown function (DUF1447)
A6F53_RS08690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6F53_RS08695	COG1597	lipid kinase activity
A6F53_RS08705	COG1388	LysM domain
A6F53_RS08705	COG0791	NLP P60 protein
A6F53_RS08730	COG1609	Transcriptional regulator
A6F53_RS08735	COG0667	Aldo Keto reductase
A6F53_RS08740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6F53_RS08745	COG4166	transmembrane transport
A6F53_RS08755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F53_RS08760	COG0765	amino acid transport
A6F53_RS08770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6F53_RS08775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6F53_RS08790	COG0482	sulfurtransferase activity
A6F53_RS08800	COG1104	cysteine desulfurase activity
A6F53_RS08805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F53_RS08815	COG0494	nUDIX hydrolase
A6F53_RS08820	COG1278	Cold shock
A6F53_RS08825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F53_RS08830	COG3599	regulation of cell shape
A6F53_RS08845	COG1799	cell septum assembly
A6F53_RS08850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6F53_RS08860	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F53_RS08865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F53_RS08870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F53_RS08875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F53_RS08880	COG0768	penicillin binding
A6F53_RS08890	COG0275	rRNA processing
A6F53_RS08895	COG2001	Belongs to the MraZ family
A6F53_RS08905	COG1674	ftsk spoiiie
A6F53_RS08910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F53_RS08920	COG0628	permease
A6F53_RS08925	COG3142	Participates in the control of copper homeostasis
A6F53_RS08970	COG0564	pseudouridine synthase activity
A6F53_RS08975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F53_RS08980	COG2357	RelA SpoT domain protein
A6F53_RS08990	COG1307	EDD domain protein, DegV family
A6F53_RS09005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F53_RS09010	COG0510	thiamine kinase activity
A6F53_RS09020	COG1131	(ABC) transporter
A6F53_RS09025	COG0537	adenosine 5'-monophosphoramidase activity
A6F53_RS09035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F53_RS09045	COG4717	serine-type aminopeptidase activity
A6F53_RS09050	COG0420	3'-5' exonuclease activity
A6F53_RS09055	COG3679	Belongs to the UPF0342 family
A6F53_RS09060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F53_RS09065	COG1438	arginine binding
A6F53_RS09070	COG0018	arginyl-trna synthetase
A6F53_RS09085	COG3266	domain, Protein
A6F53_RS09085	COG4193	domain, Protein
A6F53_RS09085	COG5632	N-Acetylmuramoyl-L-alanine amidase
A6F53_RS09130	COG1794	racemase activity, acting on amino acids and derivatives
A6F53_RS09140	COG0367	asparagine synthase
A6F53_RS09180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F53_RS09200	COG1846	Transcriptional regulator
A6F53_RS09215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6F53_RS09220	COG1554	hydrolase, family 65, central catalytic
A6F53_RS09225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F53_RS09235	COG1428	Deoxynucleoside kinase
A6F53_RS09245	COG0477	Major facilitator Superfamily
A6F53_RS09250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6F53_RS09270	COG0393	Putative heavy-metal-binding
A6F53_RS09350	COG1368	sulfuric ester hydrolase activity
A6F53_RS09365	COG0438	transferase activity, transferring glycosyl groups
A6F53_RS09370	COG0438	transferase activity, transferring glycosyl groups
A6F53_RS09375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F53_RS09390	COG0542	response to heat
A6F53_RS09410	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F53_RS09420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6F53_RS09430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6F53_RS09440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6F53_RS09445	COG0628	permease
A6F53_RS09450	COG3557	Belongs to the UPF0374 family
A6F53_RS09465	COG2137	regulation of response to DNA damage stimulus
A6F53_RS09475	COG1295	ribonuclease BN
A6F53_RS09485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F53_RS09490	COG0463	Glycosyl transferase, family 2
A6F53_RS09495	COG2610	gluconate transmembrane transporter activity
A6F53_RS09515	COG0513	Belongs to the DEAD box helicase family
A6F53_RS09535	COG1737	Transcriptional regulator
A6F53_RS09540	COG1070	Carbohydrate kinase
A6F53_RS09550	COG0531	amino acid
A6F53_RS09555	COG0738	Major facilitator superfamily
A6F53_RS09560	COG1869	D-ribose catabolic process
A6F53_RS09565	COG2918	glutathione biosynthetic process
A6F53_RS09565	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F53_RS09575	COG2390	Transcriptional regulator
A6F53_RS09580	COG0813	purine-nucleoside phosphorylase activity
A6F53_RS09585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6F53_RS09590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6F53_RS09605	COG2365	Tyrosine phosphatase family
A6F53_RS09610	COG1902	pentaerythritol trinitrate reductase activity
A6F53_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
A6F53_RS09645	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A6F53_RS09655	COG4869	propanediol catabolic process
A6F53_RS09710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6F53_RS09720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F53_RS09725	COG1597	lipid kinase activity
A6F53_RS09730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F53_RS09735	COG0154	amidase activity
A6F53_RS09740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F53_RS09745	COG4851	CamS sex pheromone cAM373 precursor
A6F53_RS09750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F53_RS09760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F53_RS09765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F53_RS09780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6F53_RS09785	COG4988	ABC transporter
A6F53_RS09790	COG1294	oxidase, subunit
A6F53_RS09795	COG1271	oxidase subunit
A6F53_RS09805	COG2365	Tyrosine phosphatase family
A6F53_RS09825	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6F53_RS09830	COG1088	dTDP-glucose 4,6-dehydratase activity
A6F53_RS09845	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6F53_RS09895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F53_RS09900	COG0562	UDP-galactopyranose mutase
A6F53_RS09915	COG1088	dTDP-glucose 4,6-dehydratase activity
A6F53_RS09945	COG1215	transferase activity, transferring glycosyl groups
A6F53_RS09945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6F53_RS09960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F53_RS09965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F53_RS09970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6F53_RS09975	COG4464	protein tyrosine phosphatase activity
A6F53_RS09980	COG0489	protein tyrosine kinase activity
A6F53_RS09990	COG1316	TRANSCRIPTIONal
A6F53_RS09995	COG0095	Lipoate-protein ligase
A6F53_RS10000	COG0531	amino acid
A6F53_RS10005	COG2502	aspartate--ammonia ligase
A6F53_RS10010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F53_RS10020	COG0307	riboflavin synthase, alpha
A6F53_RS10025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F53_RS10025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F53_RS10030	COG0569	domain protein
A6F53_RS10035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6F53_RS10040	COG1482	cell wall glycoprotein biosynthetic process
A6F53_RS10045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F53_RS10050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6F53_RS10055	COG0101	tRNA pseudouridine synthase activity
A6F53_RS10060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6F53_RS10065	COG1122	ATPase activity
A6F53_RS10070	COG1122	ATPase activity
A6F53_RS10075	COG0203	ribosomal protein L17
A6F53_RS10080	COG0202	RNA polymerase activity
A6F53_RS10085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6F53_RS10090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6F53_RS10095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6F53_RS10100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F53_RS10115	COG0200	Binds to the 23S rRNA
A6F53_RS10120	COG1841	ribosomal large subunit assembly
A6F53_RS10125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6F53_RS10130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F53_RS10135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6F53_RS10140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6F53_RS10145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6F53_RS10150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6F53_RS10155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6F53_RS10160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F53_RS10165	COG0255	Belongs to the universal ribosomal protein uL29 family
A6F53_RS10170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6F53_RS10175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F53_RS10180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6F53_RS10185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F53_RS10190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6F53_RS10195	COG0089	rRNA binding
A6F53_RS10200	COG0088	Forms part of the polypeptide exit tunnel
A6F53_RS10205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6F53_RS10210	COG0051	transcription antitermination factor activity, RNA binding
A6F53_RS10220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F53_RS10225	COG0049	tRNA binding
A6F53_RS10230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F53_RS10240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F53_RS10245	COG0085	RNA polymerase activity
A6F53_RS10255	COG0542	response to heat
A6F53_RS10260	COG4463	regulation of RNA biosynthetic process
A6F53_RS10305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6F53_RS10310	COG1428	Deoxynucleoside kinase
A6F53_RS10315	COG0833	amino acid
A6F53_RS10365	COG2814	Major facilitator Superfamily
A6F53_RS10380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6F53_RS10405	COG0456	acetyltransferase
A6F53_RS10425	COG0564	pseudouridine synthase activity
A6F53_RS10440	COG0110	maltose O-acetyltransferase activity
A6F53_RS10445	COG2160	L-arabinose isomerase activity
A6F53_RS10465	COG2207	Transcriptional regulator
A6F53_RS10465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6F53_RS10505	COG3940	Belongs to the glycosyl hydrolase 43 family
A6F53_RS10520	COG0514	ATP-dependent DNA helicase (RecQ)
A6F53_RS10535	COG4690	dipeptidase activity
A6F53_RS10545	COG0308	aminopeptidase N
A6F53_RS10570	COG0519	Catalyzes the synthesis of GMP from XMP
A6F53_RS10570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F53_RS10580	COG1072	(Pantothenic acid kinase))
A6F53_RS10585	COG3973	AAA domain
A6F53_RS10590	COG0569	domain protein
A6F53_RS10590	COG0475	glutathione-regulated potassium exporter activity
A6F53_RS10600	COG4608	Belongs to the ABC transporter superfamily
A6F53_RS10605	COG0444	Belongs to the ABC transporter superfamily
A6F53_RS10610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6F53_RS10615	COG0601	transmembrane transport
A6F53_RS10620	COG4166	transmembrane transport
A6F53_RS10625	COG4166	transmembrane transport
A6F53_RS10630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F53_RS10635	COG0765	amino acid transport
A6F53_RS10640	COG0765	amino acid transport
A6F53_RS10645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F53_RS10650	COG1126	abc transporter atp-binding protein
A6F53_RS10665	COG0735	belongs to the Fur family
A6F53_RS10670	COG0194	GDP metabolic process
A6F53_RS10680	COG0531	amino acid
A6F53_RS10685	COG2936	dipeptidyl-peptidase activity
A6F53_RS10690	COG2267	carboxylic ester hydrolase activity
A6F53_RS10695	COG1376	ErfK ybiS ycfS ynhG family protein
A6F53_RS10700	COG0488	(ABC) transporter
A6F53_RS10715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6F53_RS10720	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6F53_RS10730	COG1307	EDD domain protein, DegV family
A6F53_RS10740	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6F53_RS10780	COG2084	Dehydrogenase
A6F53_RS10785	COG0861	Integral membrane protein TerC family
A6F53_RS10795	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6F53_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS10825	COG2814	Major facilitator Superfamily
A6F53_RS10835	COG0789	Transcriptional regulator
A6F53_RS10840	COG1388	LysM domain
A6F53_RS10840	COG3103	Sh3 type 3 domain protein
A6F53_RS10840	COG0791	NLP P60 protein
A6F53_RS10850	COG0588	phosphoglycerate mutase activity
A6F53_RS10855	COG1368	sulfuric ester hydrolase activity
A6F53_RS10860	COG0492	ferredoxin-NADP+ reductase activity
A6F53_RS10890	COG0561	phosphatase activity
A6F53_RS10900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6F53_RS10905	COG0561	phosphatase activity
A6F53_RS10925	COG1686	Belongs to the peptidase S11 family
A6F53_RS10930	COG1686	Belongs to the peptidase S11 family
A6F53_RS10940	COG4172	Belongs to the ABC transporter superfamily
A6F53_RS10950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6F53_RS10985	COG2233	PERMEase
A6F53_RS10990	COG4152	abc transporter atp-binding protein
A6F53_RS10995	COG1668	transmembrane transport
A6F53_RS11015	COG0656	L-ascorbic acid biosynthetic process
A6F53_RS11030	COG0076	glutamate decarboxylase activity
A6F53_RS11035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F53_RS11040	COG3875	lactate racemase activity
A6F53_RS11045	COG1691	(AIR) carboxylase
A6F53_RS11050	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A6F53_RS11055	COG1606	tRNA processing
A6F53_RS11060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6F53_RS11065	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A6F53_RS11095	COG3842	ATPase activity
A6F53_RS11100	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6F53_RS11115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F53_RS11120	COG0581	inorganic phosphate transmembrane transporter activity
A6F53_RS11125	COG0573	inorganic phosphate transmembrane transporter activity
A6F53_RS11165	COG2706	6-phosphogluconolactonase activity
A6F53_RS11175	COG0531	amino acid
A6F53_RS11190	COG0735	belongs to the Fur family
A6F53_RS11215	COG0589	response to stress
A6F53_RS11230	COG1846	Transcriptional regulator
A6F53_RS11235	COG3590	peptidase
A6F53_RS11240	COG2096	Adenosyltransferase
A6F53_RS11245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F53_RS11260	COG1609	Transcriptional regulator
A6F53_RS11265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A6F53_RS11270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6F53_RS11275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6F53_RS11280	COG2211	Major facilitator Superfamily
A6F53_RS11280	COG2190	(PTS) system
A6F53_RS11290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F53_RS11295	COG2017	converts alpha-aldose to the beta-anomer
A6F53_RS11300	COG1960	acyl-CoA dehydrogenase activity
A6F53_RS11310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6F53_RS11315	COG0604	alcohol dehydrogenase
A6F53_RS11320	COG0640	Transcriptional regulator
A6F53_RS11345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6F53_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
A6F53_RS11360	COG2814	Major facilitator Superfamily
A6F53_RS11365	COG0024	Methionine aminopeptidase
A6F53_RS11370	COG2226	methyltransferase
A6F53_RS11380	COG2094	Belongs to the DNA glycosylase MPG family
A6F53_RS11385	COG3189	MarR family transcriptional regulator
A6F53_RS11390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6F53_RS11405	COG0110	maltose O-acetyltransferase activity
A6F53_RS11415	COG0328	RNA-DNA hybrid ribonuclease activity
A6F53_RS11425	COG0402	S-adenosylhomocysteine deaminase activity
A6F53_RS11435	COG0351	phosphomethylpyrimidine kinase
A6F53_RS11445	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6F53_RS11470	COG1278	Cold shock
A6F53_RS11475	COG0400	carboxylic ester hydrolase activity
A6F53_RS11490	COG4166	transmembrane transport
A6F53_RS11510	COG0509	glycine decarboxylation via glycine cleavage system
A6F53_RS11515	COG0667	Aldo Keto reductase
A6F53_RS11525	COG0697	spore germination
A6F53_RS11530	COG2011	ABC-type metal ion transport system permease component
A6F53_RS11535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6F53_RS11540	COG1464	Belongs to the NlpA lipoprotein family
A6F53_RS11545	COG0519	Catalyzes the synthesis of GMP from XMP
A6F53_RS11550	COG4166	transmembrane transport
A6F53_RS11555	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F53_RS11560	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A6F53_RS11565	COG0419	ATPase involved in DNA repair
A6F53_RS11570	COG0420	3'-5' exonuclease activity
A6F53_RS11575	COG2818	Glycosylase
A6F53_RS11595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6F53_RS11605	COG0789	Transcriptional regulator
A6F53_RS11610	COG1309	transcriptional regulator
A6F53_RS11630	COG2814	Major facilitator Superfamily
A6F53_RS11635	COG2814	Major facilitator Superfamily
A6F53_RS11640	COG1902	pentaerythritol trinitrate reductase activity
A6F53_RS11645	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A6F53_RS11685	COG0163	prenyltransferase activity
A6F53_RS11690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6F53_RS11695	COG0583	DNA-binding transcription factor activity
A6F53_RS11700	COG0242	peptide deformylase activity
A6F53_RS11715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6F53_RS11720	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A6F53_RS11725	COG1132	(ABC) transporter
A6F53_RS11730	COG1846	Transcriptional regulator
A6F53_RS11750	COG1131	(ABC) transporter
A6F53_RS11755	COG1725	Transcriptional regulator
A6F53_RS11765	COG0386	Belongs to the glutathione peroxidase family
A6F53_RS11775	COG2814	Major facilitator Superfamily
A6F53_RS11780	COG0561	phosphatase activity
A6F53_RS11795	COG4221	oxidoreductase activity
A6F53_RS11800	COG1733	regulation of RNA biosynthetic process
A6F53_RS11805	COG1302	Protein conserved in bacteria
A6F53_RS11810	COG1302	Protein conserved in bacteria
A6F53_RS11825	COG2261	transglycosylase associated protein
A6F53_RS11840	COG0477	Major facilitator Superfamily
A6F53_RS11870	COG0436	Aminotransferase
A6F53_RS11880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F53_RS11885	COG2235	arginine
A6F53_RS11890	COG1288	antiporter activity
A6F53_RS11900	COG0784	Response regulator, receiver
A6F53_RS11905	COG1288	antiporter activity
A6F53_RS11910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F53_RS11930	COG0025	NhaP-type Na H and K H
A6F53_RS11945	COG2814	Major facilitator Superfamily
A6F53_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F53_RS11955	COG0789	Transcriptional regulator
A6F53_RS11955	COG4978	Transcriptional regulator
A6F53_RS11980	COG0588	phosphoglycerate mutase activity
A6F53_RS12005	COG0588	phosphoglycerate mutase activity
A6F53_RS12015	COG0628	permease
A6F53_RS12020	COG1940	carbohydrate kinase activity
A6F53_RS12020	COG1846	Transcriptional regulator
A6F53_RS12030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F53_RS12060	COG1511	domain protein
A6F53_RS12060	COG1511	domain protein
A6F53_RS12065	COG1686	Belongs to the peptidase S11 family
A6F53_RS12080	COG0517	IMP dehydrogenase activity
A6F53_RS12080	COG0516	GMP reductase activity
A6F53_RS12095	COG0012	GTP binding
A6F53_RS12100	COG4481	Protein conserved in bacteria
A6F53_RS12105	COG1475	DNA binding
A6F53_RS12110	COG1192	Involved in chromosome partitioning
A6F53_RS12120	COG0357	Ribosomal RNA small subunit methyltransferase G
A6F53_RS12140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F53_RS12150	COG0702	epimerase
A6F53_RS12255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6F53_RS12260	COG1136	(ABC) transporter
A6F53_RS12260	COG0577	efflux transmembrane transporter activity
A6F53_RS12265	COG0352	thiamine-phosphate diphosphorylase activity
A6F53_RS12270	COG0351	phosphomethylpyrimidine kinase
A6F53_RS12275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6F53_RS12280	COG0300	oxidoreductase activity
A6F53_RS12285	COG0390	transport system, permease component
A6F53_RS12290	COG4619	ABC transporter
A6F53_RS12295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F53_RS12335	COG0789	Transcriptional regulator
A6F53_RS12365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F53_RS12370	COG1418	mRNA catabolic process
A6F53_RS12390	COG1396	sequence-specific DNA binding
A6F53_RS12405	COG1114	Component of the transport system for branched-chain amino acids
A6F53_RS12415	COG0531	amino acid