locus-tag	class	description
SAC12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAC12_RS00010	COG0592	DNA-directed DNA polymerase activity
SAC12_RS00015	COG2501	S4 domain
SAC12_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAC12_RS00025	COG0187	DNA topoisomerase II activity
SAC12_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAC12_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
SAC12_RS00040	COG0629	single-stranded DNA binding
SAC12_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAC12_RS00055	COG4166	transmembrane transport
SAC12_RS00070	COG4166	transmembrane transport
SAC12_RS00090	COG0359	binds to the 23S rRNA
SAC12_RS00100	COG0305	Participates in initiation and elongation during chromosome replication
SAC12_RS00105	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAC12_RS00110	COG2814	Major facilitator Superfamily
SAC12_RS00120	COG4166	transmembrane transport
SAC12_RS00140	COG0745	RESPONSE REGULATOR receiver
SAC12_RS00160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SAC12_RS00170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SAC12_RS00195	COG0737	Belongs to the 5'-nucleotidase family
SAC12_RS00230	COG0791	NLP P60 protein
SAC12_RS00230	COG3883	PFAM NLP P60 protein
SAC12_RS00240	COG0488	(ABC) transporter
SAC12_RS00250	COG1846	Transcriptional regulator
SAC12_RS00260	COG1397	ADP-ribosylglycohydrolase
SAC12_RS00265	COG0110	maltose O-acetyltransferase activity
SAC12_RS00290	COG4166	transmembrane transport
SAC12_RS00335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SAC12_RS00360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAC12_RS00400	COG0076	glutamate decarboxylase activity
SAC12_RS00405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAC12_RS00450	COG0702	epimerase
SAC12_RS00480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAC12_RS00505	COG2746	aminoglycoside 3-N-acetyltransferase activity
SAC12_RS00520	COG0667	Aldo Keto reductase
SAC12_RS00530	COG2814	Major facilitator Superfamily
SAC12_RS00540	COG0778	Nitroreductase
SAC12_RS00550	COG0488	(ABC) transporter
SAC12_RS00555	COG0477	Major facilitator Superfamily
SAC12_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS00570	COG1609	Transcriptional regulator
SAC12_RS00575	COG1253	flavin adenine dinucleotide binding
SAC12_RS00590	COG0531	amino acid
SAC12_RS00595	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS00615	COG1012	belongs to the aldehyde dehydrogenase family
SAC12_RS00615	COG1454	alcohol dehydrogenase
SAC12_RS00620	COG1388	LysM domain
SAC12_RS00620	COG0791	NLP P60 protein
SAC12_RS00630	COG1388	LysM domain
SAC12_RS00630	COG0791	NLP P60 protein
SAC12_RS00650	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SAC12_RS00655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAC12_RS00660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAC12_RS00675	COG1131	(ABC) transporter
SAC12_RS00680	COG1418	mRNA catabolic process
SAC12_RS00685	COG0534	Mate efflux family protein
SAC12_RS00690	COG1904	glucuronate isomerase
SAC12_RS00695	COG2211	Major facilitator Superfamily
SAC12_RS00705	COG3250	beta-galactosidase activity
SAC12_RS00710	COG0246	Mannitol dehydrogenase
SAC12_RS00720	COG0588	phosphoglycerate mutase activity
SAC12_RS00725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAC12_RS00730	COG1070	Carbohydrate kinase
SAC12_RS00735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAC12_RS00745	COG1312	Catalyzes the dehydration of D-mannonate
SAC12_RS00750	COG1609	Transcriptional regulator
SAC12_RS00755	COG2211	Major facilitator Superfamily
SAC12_RS00765	COG1904	glucuronate isomerase
SAC12_RS00780	COG0477	Major facilitator Superfamily
SAC12_RS00800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAC12_RS00805	COG2188	Transcriptional regulator
SAC12_RS00815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAC12_RS00845	COG0564	pseudouridine synthase activity
SAC12_RS00880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAC12_RS00885	COG0601	transmembrane transport
SAC12_RS00890	COG4608	Belongs to the ABC transporter superfamily
SAC12_RS00905	COG0095	Lipoate-protein ligase
SAC12_RS00920	COG2115	Belongs to the xylose isomerase family
SAC12_RS00940	COG5646	InterPro IPR014922
SAC12_RS00955	COG1881	PFAM PEBP family protein
SAC12_RS00975	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS00990	COG1757	Na H antiporter
SAC12_RS01000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAC12_RS01005	COG3290	protein histidine kinase activity
SAC12_RS01010	COG4565	transcriptional regulatory protein
SAC12_RS01020	COG1309	transcriptional regulator
SAC12_RS01055	COG3479	Phenolic acid decarboxylase
SAC12_RS01060	COG1695	Transcriptional regulator
SAC12_RS01075	COG2153	protein acetylation
SAC12_RS01080	COG1846	Transcriptional regulator
SAC12_RS01110	COG1914	H( )-stimulated, divalent metal cation uptake system
SAC12_RS01115	COG0516	GMP reductase activity
SAC12_RS01120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAC12_RS01125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAC12_RS01130	COG1309	transcriptional regulator
SAC12_RS01140	COG2365	Tyrosine phosphatase family
SAC12_RS01190	COG1472	Belongs to the glycosyl hydrolase 3 family
SAC12_RS01195	COG2207	Transcriptional regulator
SAC12_RS01195	COG1917	Cupin 2, conserved barrel domain protein
SAC12_RS01205	COG2211	Major facilitator Superfamily
SAC12_RS01215	COG1335	isochorismatase
SAC12_RS01235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SAC12_RS01240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAC12_RS01245	COG0716	FMN binding
SAC12_RS01255	COG1113	amino acid transport
SAC12_RS01280	COG1064	alcohol dehydrogenase
SAC12_RS01290	COG0517	IMP dehydrogenase activity
SAC12_RS01290	COG1125	glycine betaine transport
SAC12_RS01300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAC12_RS01315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAC12_RS01335	COG0110	maltose O-acetyltransferase activity
SAC12_RS01365	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS01370	COG2217	Heavy metal translocating P-type atpase
SAC12_RS01380	COG0726	polysaccharide deacetylase
SAC12_RS01390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAC12_RS01395	COG2755	lipolytic protein G-D-S-L family
SAC12_RS01395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SAC12_RS01445	COG1942	4-Oxalocrotonate Tautomerase
SAC12_RS01460	COG1174	glycine betaine transport
SAC12_RS01465	COG1732	Glycine betaine
SAC12_RS01490	COG2837	iron assimilation
SAC12_RS01495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SAC12_RS01510	COG0463	Glycosyl transferase, family 2
SAC12_RS01525	COG0628	permease
SAC12_RS01530	COG0577	efflux transmembrane transporter activity
SAC12_RS01535	COG1136	(ABC) transporter
SAC12_RS01540	COG0366	Alpha amylase catalytic
SAC12_RS01560	COG0028	Belongs to the TPP enzyme family
SAC12_RS01575	COG5002	protein histidine kinase activity
SAC12_RS01580	COG0745	RESPONSE REGULATOR receiver
SAC12_RS01590	COG0702	epimerase
SAC12_RS01595	COG1252	NADH dehydrogenase
SAC12_RS01600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAC12_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
SAC12_RS01615	COG1414	Transcriptional regulator
SAC12_RS01630	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SAC12_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS01645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAC12_RS01660	COG1914	H( )-stimulated, divalent metal cation uptake system
SAC12_RS01665	COG1307	EDD domain protein, DegV family
SAC12_RS01675	COG3118	belongs to the thioredoxin family
SAC12_RS01680	COG1937	Protein conserved in bacteria
SAC12_RS01685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAC12_RS01690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAC12_RS01700	COG0657	acetylesterase activity
SAC12_RS01705	COG1854	S-ribosylhomocysteine lyase activity
SAC12_RS01715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAC12_RS01725	COG0583	DNA-binding transcription factor activity
SAC12_RS01775	COG0745	RESPONSE REGULATOR receiver
SAC12_RS01780	COG5002	protein histidine kinase activity
SAC12_RS01785	COG1609	Transcriptional regulator
SAC12_RS01800	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS01815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAC12_RS01820	COG2017	converts alpha-aldose to the beta-anomer
SAC12_RS01830	COG0561	phosphatase activity
SAC12_RS01840	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS01850	COG1393	Belongs to the ArsC family
SAC12_RS01855	COG1388	LysM domain
SAC12_RS01855	COG0791	NLP P60 protein
SAC12_RS01855	COG3103	Sh3 type 3 domain protein
SAC12_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS01895	COG1959	2 iron, 2 sulfur cluster binding
SAC12_RS01900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAC12_RS01910	COG1733	regulation of RNA biosynthetic process
SAC12_RS01915	COG2814	Major facilitator Superfamily
SAC12_RS01920	COG4989	oxidoreductase activity
SAC12_RS01925	COG1136	(ABC) transporter
SAC12_RS01965	COG0640	Transcriptional regulator
SAC12_RS01975	COG2855	membrane
SAC12_RS01980	COG0583	DNA-binding transcription factor activity
SAC12_RS01985	COG2814	Major facilitator Superfamily
SAC12_RS01995	COG0488	(ABC) transporter
SAC12_RS02025	COG3052	prosthetic group binding
SAC12_RS02080	COG1725	Transcriptional regulator
SAC12_RS02085	COG1131	(ABC) transporter
SAC12_RS02095	COG3835	regulator
SAC12_RS02100	COG2610	gluconate transmembrane transporter activity
SAC12_RS02105	COG1929	Belongs to the glycerate kinase type-1 family
SAC12_RS02110	COG3428	Bacterial PH domain
SAC12_RS02160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAC12_RS02185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAC12_RS02190	COG2323	membrane
SAC12_RS02250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAC12_RS02265	COG1609	Transcriptional regulator
SAC12_RS02280	COG3973	AAA domain
SAC12_RS02290	COG0248	Ppx GppA phosphatase
SAC12_RS02305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAC12_RS02315	COG1801	Protein of unknown function DUF72
SAC12_RS02320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAC12_RS02320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAC12_RS02325	COG0084	hydrolase, TatD family'
SAC12_RS02330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SAC12_RS02335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAC12_RS02340	COG4466	Protein conserved in bacteria
SAC12_RS02345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAC12_RS02350	COG1573	uracil-dna glycosylase
SAC12_RS02370	COG2723	6-phospho-beta-galactosidase activity
SAC12_RS02375	COG1940	carbohydrate kinase activity
SAC12_RS02405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAC12_RS02410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAC12_RS02415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAC12_RS02420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAC12_RS02435	COG2188	Transcriptional regulator
SAC12_RS02440	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SAC12_RS02445	COG0561	phosphatase activity
SAC12_RS02450	COG1078	dGTPase activity
SAC12_RS02455	COG0095	Lipoate-protein ligase
SAC12_RS02465	COG3343	RNA polymerase activity
SAC12_RS02470	COG0504	CTP synthase activity
SAC12_RS02490	COG0028	Belongs to the TPP enzyme family
SAC12_RS02495	COG3527	Alpha-acetolactate decarboxylase
SAC12_RS02505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAC12_RS02510	COG0254	rRNA binding
SAC12_RS02515	COG3764	Sortase (surface protein transpeptidase)
SAC12_RS02570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAC12_RS02575	COG1704	LemA family
SAC12_RS02580	COG0501	Belongs to the peptidase M48B family
SAC12_RS02590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SAC12_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
SAC12_RS02610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAC12_RS02620	COG2337	Toxic component of a toxin-antitoxin (TA) module
SAC12_RS02640	COG0193	aminoacyl-tRNA hydrolase activity
SAC12_RS02645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SAC12_RS02650	COG2244	polysaccharide biosynthetic process
SAC12_RS02655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SAC12_RS02665	COG1098	S1 RNA binding domain
SAC12_RS02670	COG0037	tRNA processing
SAC12_RS02685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SAC12_RS02690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SAC12_RS02735	COG3104	oligopeptide transport
SAC12_RS02755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAC12_RS02760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SAC12_RS02765	COG2188	Transcriptional regulator
SAC12_RS02780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SAC12_RS02785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAC12_RS02795	COG2183	response to ionizing radiation
SAC12_RS02800	COG3091	SprT-like family
SAC12_RS02805	COG0083	homoserine kinase activity
SAC12_RS02835	COG0534	Mate efflux family protein
SAC12_RS02850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAC12_RS02850	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAC12_RS02855	COG3715	PTS system
SAC12_RS02860	COG3716	PTS system mannose fructose sorbose family IID component
SAC12_RS02865	COG0628	permease
SAC12_RS02890	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAC12_RS02895	COG1316	TRANSCRIPTIONal
SAC12_RS02905	COG0697	spore germination
SAC12_RS02910	COG0588	phosphoglycerate mutase activity
SAC12_RS02925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SAC12_RS02935	COG0756	dUTP diphosphatase activity
SAC12_RS02945	COG4956	integral membrane protein (PIN domain superfamily)
SAC12_RS02950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAC12_RS02955	COG0215	cysteine-tRNA ligase activity
SAC12_RS02960	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SAC12_RS02965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAC12_RS02970	COG3688	RNA-binding protein containing a PIN domain
SAC12_RS02980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAC12_RS02990	COG0250	Participates in transcription elongation, termination and antitermination
SAC12_RS02995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAC12_RS03000	COG0081	regulation of translation
SAC12_RS03005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAC12_RS03010	COG0222	ribosome binding
SAC12_RS03015	COG0392	lysyltransferase activity
SAC12_RS03015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SAC12_RS03025	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAC12_RS03030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAC12_RS03040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SAC12_RS03045	COG2813	Specifically methylates the guanine in position
SAC12_RS03060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SAC12_RS03065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAC12_RS03070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAC12_RS03080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAC12_RS03085	COG3870	Protein conserved in bacteria
SAC12_RS03090	COG0470	DNA polymerase III
SAC12_RS03095	COG4467	Involved in initiation control of chromosome replication
SAC12_RS03110	COG1214	PFAM Peptidase M22, glycoprotease
SAC12_RS03120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAC12_RS03125	COG2807	transmembrane transport
SAC12_RS03130	COG0640	Transcriptional regulator
SAC12_RS03135	COG0488	(ABC) transporter
SAC12_RS03140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAC12_RS03145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAC12_RS03150	COG0459	protein refolding
SAC12_RS03155	COG0531	amino acid
SAC12_RS03160	COG1346	cytolysis
SAC12_RS03170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAC12_RS03175	COG1739	Uncharacterized protein family UPF0029
SAC12_RS03180	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SAC12_RS03195	COG0653	protein targeting
SAC12_RS03210	COG0745	RESPONSE REGULATOR receiver
SAC12_RS03215	COG5002	protein histidine kinase activity
SAC12_RS03235	COG0581	inorganic phosphate transmembrane transporter activity
SAC12_RS03240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAC12_RS03245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAC12_RS03250	COG0704	Plays a role in the regulation of phosphate uptake
SAC12_RS03255	COG1983	PspC domain protein
SAC12_RS03265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SAC12_RS03270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAC12_RS03275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAC12_RS03280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAC12_RS03285	COG0492	ferredoxin-NADP+ reductase activity
SAC12_RS03300	COG0556	nucleotide-excision repair
SAC12_RS03305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAC12_RS03315	COG1660	Displays ATPase and GTPase activities
SAC12_RS03320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAC12_RS03325	COG1481	regulation of sporulation
SAC12_RS03330	COG0740	serine-type endopeptidase activity
SAC12_RS03340	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS03360	COG4684	Psort location CytoplasmicMembrane, score
SAC12_RS03380	COG0126	phosphoglycerate kinase activity
SAC12_RS03385	COG0149	triose-phosphate isomerase activity
SAC12_RS03390	COG0148	phosphopyruvate hydratase activity
SAC12_RS03405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAC12_RS03415	COG0557	exoribonuclease II activity
SAC12_RS03420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAC12_RS03430	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS03440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAC12_RS03450	COG0802	atpase or kinase
SAC12_RS03460	COG0667	Aldo Keto reductase
SAC12_RS03470	COG0708	Exodeoxyribonuclease III
SAC12_RS03475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAC12_RS03480	COG0025	NhaP-type Na H and K H
SAC12_RS03490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SAC12_RS03500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAC12_RS03505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAC12_RS03515	COG0363	glucosamine-6-phosphate deaminase activity
SAC12_RS03520	COG1705	Flagellar rod assembly protein muramidase FlgJ
SAC12_RS03520	COG1388	LysM domain
SAC12_RS03540	COG1134	teichoic acid transport
SAC12_RS03570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAC12_RS03575	COG1120	ATPase activity
SAC12_RS03580	COG0248	Ppx GppA phosphatase
SAC12_RS03585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAC12_RS03595	COG3475	LICD family
SAC12_RS03620	COG3759	membrane
SAC12_RS03640	COG1609	Transcriptional regulator
SAC12_RS03660	COG2235	arginine
SAC12_RS03680	COG0745	RESPONSE REGULATOR receiver
SAC12_RS03685	COG5002	protein histidine kinase activity
SAC12_RS03685	COG3850	Histidine kinase
SAC12_RS03690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SAC12_RS03695	COG4975	Glucose uptake
SAC12_RS03700	COG0166	Belongs to the GPI family
SAC12_RS03710	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SAC12_RS03765	COG1396	sequence-specific DNA binding
SAC12_RS03825	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
SAC12_RS03895	COG1783	phage Terminase large subunit
SAC12_RS04045	COG2261	transglycosylase associated protein
SAC12_RS04060	COG1302	Protein conserved in bacteria
SAC12_RS04065	COG1302	Protein conserved in bacteria
SAC12_RS04090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SAC12_RS04095	COG2203	Gaf domain
SAC12_RS04095	COG5001	Diguanylate cyclase
SAC12_RS04095	COG4251	negative regulation of phosphorylation
SAC12_RS04095	COG3706	GGDEF domain
SAC12_RS04140	COG3442	glutamine amidotransferase
SAC12_RS04145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SAC12_RS04150	COG1435	thymidine kinase activity
SAC12_RS04155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAC12_RS04160	COG2890	protein-(glutamine-N5) methyltransferase activity
SAC12_RS04165	COG0009	L-threonylcarbamoyladenylate synthase
SAC12_RS04175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAC12_RS04180	COG0356	it plays a direct role in the translocation of protons across the membrane
SAC12_RS04185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAC12_RS04190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAC12_RS04195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAC12_RS04200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAC12_RS04205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAC12_RS04210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAC12_RS04215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAC12_RS04225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAC12_RS04230	COG1077	Cell shape determining protein MreB Mrl
SAC12_RS04235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAC12_RS04245	COG0772	Belongs to the SEDS family
SAC12_RS04250	COG0509	glycine decarboxylation via glycine cleavage system
SAC12_RS04265	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAC12_RS04280	COG0589	response to stress
SAC12_RS04290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SAC12_RS04300	COG4493	Belongs to the UPF0637 family
SAC12_RS04310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAC12_RS04315	COG1956	GAF domain-containing protein
SAC12_RS04320	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SAC12_RS04325	COG1104	cysteine desulfurase activity
SAC12_RS04330	COG0301	tRNA thio-modification
SAC12_RS04340	COG0525	valine-tRNA ligase activity
SAC12_RS04345	COG0285	dihydrofolate synthase activity
SAC12_RS04350	COG2003	Belongs to the UPF0758 family
SAC12_RS04355	COG1077	Cell shape determining protein MreB Mrl
SAC12_RS04360	COG1792	Involved in formation and maintenance of cell shape
SAC12_RS04370	COG0850	regulation of cytokinetic process
SAC12_RS04375	COG2894	cell division
SAC12_RS04380	COG0765	amino acid transport
SAC12_RS04385	COG1126	abc transporter atp-binding protein
SAC12_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAC12_RS04395	COG0612	Peptidase, M16
SAC12_RS04400	COG0612	Peptidase, M16
SAC12_RS04405	COG1426	Protein conserved in bacteria
SAC12_RS04410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAC12_RS04415	COG1058	Belongs to the CinA family
SAC12_RS04415	COG1546	Belongs to the CinA family
SAC12_RS04420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAC12_RS04430	COG1418	mRNA catabolic process
SAC12_RS04435	COG1692	metallophosphoesterase
SAC12_RS04440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SAC12_RS04445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SAC12_RS04450	COG0632	four-way junction helicase activity
SAC12_RS04455	COG2255	four-way junction helicase activity
SAC12_RS04460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAC12_RS04465	COG0343	queuine tRNA-ribosyltransferase activity
SAC12_RS04475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAC12_RS04480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SAC12_RS04490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAC12_RS04495	COG4472	Bacterial protein of unknown function (DUF965)
SAC12_RS04500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAC12_RS04505	COG3906	Belongs to the UPF0473 family
SAC12_RS04520	COG1193	negative regulation of DNA recombination
SAC12_RS04525	COG3118	belongs to the thioredoxin family
SAC12_RS04530	COG1719	4-vinyl reductase, 4VR
SAC12_RS04535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAC12_RS04540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAC12_RS04550	COG0517	IMP dehydrogenase activity
SAC12_RS04555	COG0640	Transcriptional regulator
SAC12_RS04565	COG0668	transmembrane transport
SAC12_RS04580	COG0006	proline dipeptidase activity
SAC12_RS04585	COG1609	Transcriptional regulator
SAC12_RS04595	COG1126	abc transporter atp-binding protein
SAC12_RS04600	COG0765	amino acid transport
SAC12_RS04605	COG0217	transcriptional regulatory protein
SAC12_RS04610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SAC12_RS04615	COG1459	type II secretion system
SAC12_RS04620	COG4537	Required for transformation and DNA binding
SAC12_RS04640	COG0827	DNA restriction-modification system
SAC12_RS04650	COG1113	amino acid transport
SAC12_RS04655	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS04665	COG0737	Belongs to the 5'-nucleotidase family
SAC12_RS04670	COG4470	Protein conserved in bacteria
SAC12_RS04675	COG0647	UMP catabolic process
SAC12_RS04700	COG0531	amino acid
SAC12_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS04710	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS04715	COG0586	Pfam SNARE associated Golgi protein
SAC12_RS04720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SAC12_RS04725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAC12_RS04730	COG0539	negative regulation of cytoplasmic translation
SAC12_RS04850	COG1234	tRNA 3'-trailer cleavage
SAC12_RS04855	COG1393	Belongs to the ArsC family
SAC12_RS04860	COG4862	establishment of competence for transformation
SAC12_RS04875	COG1215	transferase activity, transferring glycosyl groups
SAC12_RS04880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAC12_RS04885	COG0671	phosphoesterase, PA-phosphatase related
SAC12_RS04890	COG0495	leucyl-tRNA aminoacylation
SAC12_RS04900	COG1129	ABC transporter
SAC12_RS04915	COG2244	polysaccharide biosynthetic process
SAC12_RS04920	COG1187	pseudouridine synthase activity
SAC12_RS04925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SAC12_RS04935	COG0589	response to stress
SAC12_RS04945	COG1113	amino acid transport
SAC12_RS04955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAC12_RS04960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAC12_RS04970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAC12_RS04980	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS05010	COG0402	S-adenosylhomocysteine deaminase activity
SAC12_RS05015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAC12_RS05015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAC12_RS05020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAC12_RS05025	COG0237	dephospho-CoA kinase activity
SAC12_RS05030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAC12_RS05040	COG1484	DNA-dependent DNA replication
SAC12_RS05045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAC12_RS05050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAC12_RS05055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAC12_RS05060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAC12_RS05065	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SAC12_RS05070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SAC12_RS05080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAC12_RS05085	COG1713	HD superfamily hydrolase involved in NAD metabolism
SAC12_RS05090	COG0799	negative regulation of ribosome biogenesis
SAC12_RS05095	COG2226	methyltransferase
SAC12_RS05100	COG1323	Belongs to the UPF0348 family
SAC12_RS05110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAC12_RS05115	COG0561	phosphatase activity
SAC12_RS05120	COG0640	Transcriptional regulator
SAC12_RS05125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAC12_RS05125	COG5549	protein import
SAC12_RS05130	COG1064	alcohol dehydrogenase
SAC12_RS05135	COG0745	RESPONSE REGULATOR receiver
SAC12_RS05140	COG5002	protein histidine kinase activity
SAC12_RS05150	COG0706	membrane insertase activity
SAC12_RS05155	COG1254	Belongs to the acylphosphatase family
SAC12_RS05160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAC12_RS05170	COG1733	regulation of RNA biosynthetic process
SAC12_RS05175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAC12_RS05180	COG0072	phenylalanine-tRNA ligase activity
SAC12_RS05180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAC12_RS05185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAC12_RS05190	COG0572	uridine kinase
SAC12_RS05195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAC12_RS05210	COG2155	Conserved Protein
SAC12_RS05215	COG0768	penicillin binding
SAC12_RS05220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAC12_RS05225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAC12_RS05230	COG0457	Tetratricopeptide repeat
SAC12_RS05230	COG0705	Rhomboid family
SAC12_RS05240	COG1940	carbohydrate kinase activity
SAC12_RS05255	COG0584	glycerophosphoryl diester phosphodiesterase
SAC12_RS05260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAC12_RS05265	COG0789	Transcriptional regulator
SAC12_RS05295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAC12_RS05300	COG2868	ribosomal protein
SAC12_RS05305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAC12_RS05310	COG0006	proline dipeptidase activity
SAC12_RS05315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAC12_RS05320	COG1302	Protein conserved in bacteria
SAC12_RS05325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAC12_RS05330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAC12_RS05335	COG1570	exodeoxyribonuclease VII activity
SAC12_RS05340	COG1722	exodeoxyribonuclease VII activity
SAC12_RS05350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SAC12_RS05355	COG1438	arginine binding
SAC12_RS05360	COG0497	DNA recombination
SAC12_RS05375	COG0194	GDP metabolic process
SAC12_RS05380	COG1758	RNA polymerase activity
SAC12_RS05385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SAC12_RS05390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SAC12_RS05395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAC12_RS05400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAC12_RS05400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SAC12_RS05405	COG0631	protein serine/threonine phosphatase activity
SAC12_RS05410	COG0515	serine threonine protein kinase
SAC12_RS05410	COG2815	serine threonine protein kinase
SAC12_RS05415	COG1162	GTPase activity
SAC12_RS05420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAC12_RS05425	COG1564	THIamine pyrophosphokinase
SAC12_RS05430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAC12_RS05435	COG1302	Protein conserved in bacteria
SAC12_RS05440	COG1461	Dihydroxyacetone kinase
SAC12_RS05445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SAC12_RS05450	COG0416	fatty acid biosynthetic process
SAC12_RS05455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAC12_RS05460	COG0571	ribonuclease III activity
SAC12_RS05465	COG1196	nuclear chromosome segregation
SAC12_RS05475	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SAC12_RS05480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SAC12_RS05505	COG0228	four-way junction DNA binding
SAC12_RS05510	COG1837	Belongs to the UPF0109 family
SAC12_RS05515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAC12_RS05520	COG0336	Belongs to the RNA methyltransferase TrmD family
SAC12_RS05525	COG0335	large ribosomal subunit rRNA binding
SAC12_RS05535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAC12_RS05545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAC12_RS05550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAC12_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS05570	COG0511	ligase activity, forming carbon-carbon bonds
SAC12_RS05575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAC12_RS05580	COG0439	Biotin carboxylase
SAC12_RS05585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAC12_RS05590	COG0825	malonyl-CoA metabolic process
SAC12_RS05595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAC12_RS05605	COG1268	BioY protein
SAC12_RS05610	COG1694	Mazg nucleotide pyrophosphohydrolase
SAC12_RS05660	COG0789	Transcriptional regulator
SAC12_RS05665	COG0667	Aldo Keto reductase
SAC12_RS05670	COG1162	GTPase activity
SAC12_RS05690	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAC12_RS05715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAC12_RS05720	COG1942	4-Oxalocrotonate Tautomerase
SAC12_RS05725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAC12_RS05740	COG3655	Transcriptional regulator
SAC12_RS05755	COG1215	transferase activity, transferring glycosyl groups
SAC12_RS05765	COG1136	(ABC) transporter
SAC12_RS05765	COG0577	efflux transmembrane transporter activity
SAC12_RS05775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAC12_RS05810	COG1309	transcriptional regulator
SAC12_RS05815	COG1304	FMN binding
SAC12_RS05825	COG0025	NhaP-type Na H and K H
SAC12_RS05835	COG2807	transmembrane transport
SAC12_RS05840	COG3158	transport of potassium into the cell
SAC12_RS05855	COG0789	Transcriptional regulator
SAC12_RS05880	COG0583	DNA-binding transcription factor activity
SAC12_RS05900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAC12_RS05910	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SAC12_RS05910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SAC12_RS05915	COG1304	FMN binding
SAC12_RS05935	COG1199	ATP-dependent helicase activity
SAC12_RS05935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAC12_RS05965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAC12_RS05970	COG3331	DNA recombination
SAC12_RS05975	COG4474	Belongs to the UPF0398 family
SAC12_RS05980	COG3599	regulation of cell shape
SAC12_RS05990	COG0116	Belongs to the methyltransferase superfamily
SAC12_RS06000	COG0004	ammonium transporteR
SAC12_RS06035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAC12_RS06055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAC12_RS06060	COG0564	pseudouridine synthase activity
SAC12_RS06065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAC12_RS06075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAC12_RS06080	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SAC12_RS06085	COG1846	Transcriptional regulator
SAC12_RS06095	COG2270	Major facilitator Superfamily
SAC12_RS06100	COG1307	EDD domain protein, DegV family
SAC12_RS06105	COG4720	Psort location CytoplasmicMembrane, score
SAC12_RS06110	COG2246	polysaccharide biosynthetic process
SAC12_RS06125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SAC12_RS06145	COG2226	methyltransferase
SAC12_RS06155	COG4974	Belongs to the 'phage' integrase family
SAC12_RS06170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAC12_RS06180	COG1227	inorganic diphosphatase activity
SAC12_RS06185	COG0583	DNA-binding transcription factor activity
SAC12_RS06195	COG0187	DNA topoisomerase II activity
SAC12_RS06200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SAC12_RS06210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SAC12_RS06215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SAC12_RS06225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAC12_RS06230	COG0758	DNA mediated transformation
SAC12_RS06235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAC12_RS06240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SAC12_RS06260	COG1070	Carbohydrate kinase
SAC12_RS06275	COG4479	Belongs to the UPF0346 family
SAC12_RS06285	COG2755	lipolytic protein G-D-S-L family
SAC12_RS06290	COG1307	EDD domain protein, DegV family
SAC12_RS06295	COG1272	protein, Hemolysin III
SAC12_RS06305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAC12_RS06310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SAC12_RS06315	COG0488	(ABC) transporter
SAC12_RS06320	COG0617	tRNA 3'-terminal CCA addition
SAC12_RS06325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAC12_RS06330	COG0457	Tetratricopeptide repeat
SAC12_RS06340	COG1160	GTP binding
SAC12_RS06345	COG0539	negative regulation of cytoplasmic translation
SAC12_RS06350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAC12_RS06355	COG1705	Flagellar rod assembly protein muramidase FlgJ
SAC12_RS06355	COG1388	LysM domain
SAC12_RS06360	COG0514	ATP-dependent DNA helicase (RecQ)
SAC12_RS06370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SAC12_RS06375	COG1187	pseudouridine synthase activity
SAC12_RS06380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAC12_RS06385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAC12_RS06400	COG2996	Protein conserved in bacteria
SAC12_RS06415	COG0587	DNA-directed DNA polymerase activity
SAC12_RS06420	COG0542	response to heat
SAC12_RS06430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAC12_RS06435	COG2384	SAM-dependent methyltransferase
SAC12_RS06440	COG1033	growth of symbiont in host cell
SAC12_RS06440	COG2409	Drug exporters of the RND superfamily
SAC12_RS06445	COG1959	2 iron, 2 sulfur cluster binding
SAC12_RS06450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAC12_RS06455	COG0358	DNA primase activity
SAC12_RS06460	COG0751	glycine-tRNA ligase activity
SAC12_RS06465	COG0752	glycyl-tRNA synthetase alpha subunit
SAC12_RS06470	COG1381	Involved in DNA repair and RecF pathway recombination
SAC12_RS06475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAC12_RS06480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SAC12_RS06485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAC12_RS06490	COG1702	phosphate starvation-inducible protein PhoH
SAC12_RS06495	COG1610	YqeY-like protein
SAC12_RS06500	COG1733	regulation of RNA biosynthetic process
SAC12_RS06510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SAC12_RS06515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SAC12_RS06520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAC12_RS06525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAC12_RS06530	COG1682	transport, permease protein
SAC12_RS06540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAC12_RS06545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAC12_RS06550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAC12_RS06555	COG0124	histidyl-tRNA synthetase
SAC12_RS06565	COG0860	N-Acetylmuramoyl-L-alanine amidase
SAC12_RS06570	COG3001	Fructosamine kinase
SAC12_RS06580	COG1490	D-aminoacyl-tRNA deacylase activity
SAC12_RS06585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAC12_RS06595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SAC12_RS06600	COG2264	protein methyltransferase activity
SAC12_RS06610	COG1970	mechanosensitive ion channel activity
SAC12_RS06625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAC12_RS06630	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS06670	COG0481	GTPase activity
SAC12_RS06675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SAC12_RS06680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAC12_RS06685	COG1696	Membrane protein involved in D-alanine export
SAC12_RS06690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAC12_RS06700	COG0484	heat shock protein binding
SAC12_RS06705	COG0443	Heat shock 70 kDa protein
SAC12_RS06710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAC12_RS06715	COG1420	regulation of RNA biosynthetic process
SAC12_RS06720	COG0196	riboflavin kinase activity
SAC12_RS06725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAC12_RS06730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAC12_RS06735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAC12_RS06745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SAC12_RS06750	COG0195	Participates in both transcription termination and antitermination
SAC12_RS06755	COG0779	Required for maturation of 30S ribosomal subunits
SAC12_RS06765	COG2176	DNA-directed DNA polymerase activity
SAC12_RS06770	COG0442	prolyl-tRNA aminoacylation
SAC12_RS06775	COG0750	zinc metalloprotease
SAC12_RS06780	COG4589	Belongs to the CDS family
SAC12_RS06785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAC12_RS06800	COG0528	UMP kinase activity
SAC12_RS06805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAC12_RS06810	COG0052	Belongs to the universal ribosomal protein uS2 family
SAC12_RS06820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAC12_RS06825	COG2827	Endonuclease containing a URI domain
SAC12_RS06830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SAC12_RS06835	COG0204	Acyl-transferase
SAC12_RS06840	COG1132	(ABC) transporter
SAC12_RS06845	COG1132	(ABC) transporter
SAC12_RS06850	COG3763	UPF0154 protein
SAC12_RS06855	COG4224	UPF0291 protein
SAC12_RS06860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAC12_RS06875	COG3425	synthase
SAC12_RS06880	COG2326	polyphosphate kinase activity
SAC12_RS06895	COG0105	UTP biosynthetic process
SAC12_RS07100	COG0305	Participates in initiation and elongation during chromosome replication
SAC12_RS07185	COG0582	viral genome integration into host DNA
SAC12_RS07255	COG0305	Participates in initiation and elongation during chromosome replication
SAC12_RS07325	COG1396	sequence-specific DNA binding
SAC12_RS07345	COG0582	viral genome integration into host DNA
SAC12_RS07360	COG1597	lipid kinase activity
SAC12_RS07375	COG0589	response to stress
SAC12_RS07380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAC12_RS07385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SAC12_RS07385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SAC12_RS07390	COG5416	Lipopolysaccharide assembly protein A domain
SAC12_RS07395	COG1234	tRNA 3'-trailer cleavage
SAC12_RS07410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAC12_RS07415	COG0322	excinuclease ABC activity
SAC12_RS07430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SAC12_RS07435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAC12_RS07440	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAC12_RS07445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAC12_RS07460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAC12_RS07465	COG0268	Binds directly to 16S ribosomal RNA
SAC12_RS07470	COG1466	dna polymerase III delta subunit
SAC12_RS07475	COG0658	competence protein
SAC12_RS07475	COG2333	competence protein COMEC
SAC12_RS07480	COG2131	deaminase
SAC12_RS07490	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAC12_RS07495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAC12_RS07500	COG0742	ribosomal rna small subunit methyltransferase
SAC12_RS07505	COG4471	UPF0298 protein
SAC12_RS07510	COG0772	Belongs to the SEDS family
SAC12_RS07515	COG1217	gtp-binding protein TYPA
SAC12_RS07520	COG0483	inositol monophosphate 1-phosphatase activity
SAC12_RS07525	COG4476	Belongs to the UPF0223 family
SAC12_RS07550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SAC12_RS07555	COG0242	peptide deformylase activity
SAC12_RS07565	COG5503	Protein of unknown function (DUF1447)
SAC12_RS07570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAC12_RS07575	COG1597	lipid kinase activity
SAC12_RS07585	COG1388	LysM domain
SAC12_RS07585	COG0791	NLP P60 protein
SAC12_RS07595	COG0791	NLP P60 protein
SAC12_RS07610	COG1609	Transcriptional regulator
SAC12_RS07615	COG0667	Aldo Keto reductase
SAC12_RS07620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAC12_RS07625	COG4166	transmembrane transport
SAC12_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAC12_RS07640	COG0765	amino acid transport
SAC12_RS07650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAC12_RS07655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAC12_RS07670	COG0482	sulfurtransferase activity
SAC12_RS07680	COG1104	cysteine desulfurase activity
SAC12_RS07685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAC12_RS07695	COG0494	nUDIX hydrolase
SAC12_RS07700	COG1278	Cold shock
SAC12_RS07705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAC12_RS07710	COG3599	regulation of cell shape
SAC12_RS07725	COG1799	cell septum assembly
SAC12_RS07730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAC12_RS07740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAC12_RS07745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAC12_RS07750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAC12_RS07755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAC12_RS07760	COG0768	penicillin binding
SAC12_RS07770	COG0275	rRNA processing
SAC12_RS07775	COG2001	Belongs to the MraZ family
SAC12_RS07790	COG1674	ftsk spoiiie
SAC12_RS07795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SAC12_RS07805	COG0628	permease
SAC12_RS07810	COG3142	Participates in the control of copper homeostasis
SAC12_RS07855	COG0564	pseudouridine synthase activity
SAC12_RS07860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAC12_RS07865	COG2357	RelA SpoT domain protein
SAC12_RS07875	COG1307	EDD domain protein, DegV family
SAC12_RS07890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAC12_RS07895	COG0510	thiamine kinase activity
SAC12_RS07905	COG1131	(ABC) transporter
SAC12_RS07910	COG0537	adenosine 5'-monophosphoramidase activity
SAC12_RS07920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SAC12_RS07930	COG4717	serine-type aminopeptidase activity
SAC12_RS07935	COG0420	3'-5' exonuclease activity
SAC12_RS07940	COG3679	Belongs to the UPF0342 family
SAC12_RS07945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAC12_RS07950	COG1438	arginine binding
SAC12_RS07955	COG0018	arginyl-trna synthetase
SAC12_RS07970	COG5632	N-Acetylmuramoyl-L-alanine amidase
SAC12_RS07970	COG3266	domain, Protein
SAC12_RS07970	COG4193	domain, Protein
SAC12_RS07985	COG1794	racemase activity, acting on amino acids and derivatives
SAC12_RS07995	COG0367	asparagine synthase
SAC12_RS08025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAC12_RS08065	COG1846	Transcriptional regulator
SAC12_RS08080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAC12_RS08085	COG1554	hydrolase, family 65, central catalytic
SAC12_RS08090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAC12_RS08100	COG1428	Deoxynucleoside kinase
SAC12_RS08110	COG0477	Major facilitator Superfamily
SAC12_RS08115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAC12_RS08135	COG0393	Putative heavy-metal-binding
SAC12_RS08230	COG1368	sulfuric ester hydrolase activity
SAC12_RS08245	COG0438	transferase activity, transferring glycosyl groups
SAC12_RS08250	COG0438	transferase activity, transferring glycosyl groups
SAC12_RS08255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAC12_RS08270	COG0542	response to heat
SAC12_RS08305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SAC12_RS08315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAC12_RS08325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAC12_RS08330	COG0628	permease
SAC12_RS08335	COG3557	Belongs to the UPF0374 family
SAC12_RS08350	COG2137	regulation of response to DNA damage stimulus
SAC12_RS08360	COG1295	ribonuclease BN
SAC12_RS08370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SAC12_RS08375	COG0463	Glycosyl transferase, family 2
SAC12_RS08380	COG2610	gluconate transmembrane transporter activity
SAC12_RS08400	COG0513	Belongs to the DEAD box helicase family
SAC12_RS08420	COG1737	Transcriptional regulator
SAC12_RS08425	COG1070	Carbohydrate kinase
SAC12_RS08435	COG0531	amino acid
SAC12_RS08440	COG0738	Major facilitator superfamily
SAC12_RS08445	COG1869	D-ribose catabolic process
SAC12_RS08450	COG2918	glutathione biosynthetic process
SAC12_RS08450	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAC12_RS08460	COG2390	Transcriptional regulator
SAC12_RS08465	COG0813	purine-nucleoside phosphorylase activity
SAC12_RS08470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SAC12_RS08475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SAC12_RS08490	COG2365	Tyrosine phosphatase family
SAC12_RS08495	COG1902	pentaerythritol trinitrate reductase activity
SAC12_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
SAC12_RS08530	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SAC12_RS08540	COG4869	propanediol catabolic process
SAC12_RS08595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAC12_RS08630	COG1401	restriction endodeoxyribonuclease activity
SAC12_RS08645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SAC12_RS08655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAC12_RS08660	COG1597	lipid kinase activity
SAC12_RS08665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAC12_RS08670	COG0154	amidase activity
SAC12_RS08675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAC12_RS08680	COG4851	CamS sex pheromone cAM373 precursor
SAC12_RS08685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAC12_RS08695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SAC12_RS08700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAC12_RS08715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SAC12_RS08720	COG4988	ABC transporter
SAC12_RS08725	COG1294	oxidase, subunit
SAC12_RS08730	COG1271	oxidase subunit
SAC12_RS08740	COG1088	dTDP-glucose 4,6-dehydratase activity
SAC12_RS08755	COG1088	dTDP-glucose 4,6-dehydratase activity
SAC12_RS08765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SAC12_RS08785	COG0463	Glycosyl transferase, family 2
SAC12_RS08800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAC12_RS08805	COG4464	protein tyrosine phosphatase activity
SAC12_RS08810	COG0489	protein tyrosine kinase activity
SAC12_RS08820	COG1316	TRANSCRIPTIONal
SAC12_RS08825	COG0095	Lipoate-protein ligase
SAC12_RS08830	COG0531	amino acid
SAC12_RS08835	COG2502	aspartate--ammonia ligase
SAC12_RS08840	COG0569	domain protein
SAC12_RS08845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAC12_RS08850	COG1482	cell wall glycoprotein biosynthetic process
SAC12_RS08855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAC12_RS08860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAC12_RS08865	COG0101	tRNA pseudouridine synthase activity
SAC12_RS08870	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SAC12_RS08875	COG1122	ATPase activity
SAC12_RS08880	COG1122	ATPase activity
SAC12_RS08885	COG0203	ribosomal protein L17
SAC12_RS08890	COG0202	RNA polymerase activity
SAC12_RS08895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAC12_RS08900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAC12_RS08905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAC12_RS08910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAC12_RS08925	COG0200	Binds to the 23S rRNA
SAC12_RS08930	COG1841	ribosomal large subunit assembly
SAC12_RS08935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAC12_RS08940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAC12_RS08945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAC12_RS08950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAC12_RS08955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAC12_RS08960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAC12_RS08965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAC12_RS08970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAC12_RS08975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAC12_RS08980	COG0255	Belongs to the universal ribosomal protein uL29 family
SAC12_RS08985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAC12_RS08990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAC12_RS08995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAC12_RS09000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAC12_RS09005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAC12_RS09010	COG0089	rRNA binding
SAC12_RS09015	COG0088	Forms part of the polypeptide exit tunnel
SAC12_RS09020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAC12_RS09025	COG0051	transcription antitermination factor activity, RNA binding
SAC12_RS09035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAC12_RS09040	COG0049	tRNA binding
SAC12_RS09045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAC12_RS09060	COG0085	RNA polymerase activity
SAC12_RS09070	COG0542	response to heat
SAC12_RS09075	COG4463	regulation of RNA biosynthetic process
SAC12_RS09120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAC12_RS09125	COG1428	Deoxynucleoside kinase
SAC12_RS09130	COG0833	amino acid
SAC12_RS09180	COG2814	Major facilitator Superfamily
SAC12_RS09195	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SAC12_RS09205	COG2233	PERMEase
SAC12_RS09220	COG0456	acetyltransferase
SAC12_RS09240	COG0564	pseudouridine synthase activity
SAC12_RS09255	COG0110	maltose O-acetyltransferase activity
SAC12_RS09260	COG2160	L-arabinose isomerase activity
SAC12_RS09280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAC12_RS09280	COG2207	Transcriptional regulator
SAC12_RS09320	COG3940	Belongs to the glycosyl hydrolase 43 family
SAC12_RS09355	COG0395	ABC-type sugar transport system, permease component
SAC12_RS09370	COG3842	ATPase activity
SAC12_RS09375	COG3534	alpha-L-arabinofuranosidase
SAC12_RS09380	COG0514	ATP-dependent DNA helicase (RecQ)
SAC12_RS09395	COG4690	dipeptidase activity
SAC12_RS09405	COG0308	aminopeptidase N
SAC12_RS09420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAC12_RS09420	COG0519	Catalyzes the synthesis of GMP from XMP
SAC12_RS09430	COG1072	(Pantothenic acid kinase))
SAC12_RS09435	COG3973	AAA domain
SAC12_RS09440	COG0569	domain protein
SAC12_RS09440	COG0475	glutathione-regulated potassium exporter activity
SAC12_RS09450	COG4608	Belongs to the ABC transporter superfamily
SAC12_RS09455	COG0444	Belongs to the ABC transporter superfamily
SAC12_RS09460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAC12_RS09465	COG0601	transmembrane transport
SAC12_RS09470	COG4166	transmembrane transport
SAC12_RS09475	COG4166	transmembrane transport
SAC12_RS09480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAC12_RS09485	COG0765	amino acid transport
SAC12_RS09490	COG0765	amino acid transport
SAC12_RS09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAC12_RS09500	COG1126	abc transporter atp-binding protein
SAC12_RS09515	COG0735	belongs to the Fur family
SAC12_RS09520	COG0194	GDP metabolic process
SAC12_RS09530	COG0531	amino acid
SAC12_RS09535	COG2936	dipeptidyl-peptidase activity
SAC12_RS09540	COG2267	carboxylic ester hydrolase activity
SAC12_RS09545	COG1376	ErfK ybiS ycfS ynhG family protein
SAC12_RS09550	COG0488	(ABC) transporter
SAC12_RS09565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAC12_RS09570	COG4120	Belongs to the binding-protein-dependent transport system permease family
SAC12_RS09580	COG1307	EDD domain protein, DegV family
SAC12_RS09590	COG4120	Belongs to the binding-protein-dependent transport system permease family
SAC12_RS09605	COG2084	Dehydrogenase
SAC12_RS09620	COG1705	Flagellar rod assembly protein muramidase FlgJ
SAC12_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
SAC12_RS09650	COG2814	Major facilitator Superfamily
SAC12_RS09660	COG0789	Transcriptional regulator
SAC12_RS09665	COG1388	LysM domain
SAC12_RS09665	COG0791	NLP P60 protein
SAC12_RS09665	COG3103	Sh3 type 3 domain protein
SAC12_RS09675	COG0588	phosphoglycerate mutase activity
SAC12_RS09680	COG1368	sulfuric ester hydrolase activity
SAC12_RS09685	COG0492	ferredoxin-NADP+ reductase activity
SAC12_RS09720	COG0561	phosphatase activity
SAC12_RS09730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAC12_RS09740	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS09760	COG1686	Belongs to the peptidase S11 family
SAC12_RS09765	COG1686	Belongs to the peptidase S11 family
SAC12_RS09775	COG4172	Belongs to the ABC transporter superfamily
SAC12_RS09785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SAC12_RS09820	COG2233	PERMEase
SAC12_RS09825	COG4152	abc transporter atp-binding protein
SAC12_RS09830	COG1668	transmembrane transport
SAC12_RS09850	COG0656	L-ascorbic acid biosynthetic process
SAC12_RS09865	COG0076	glutamate decarboxylase activity
SAC12_RS09870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAC12_RS09875	COG3875	lactate racemase activity
SAC12_RS09880	COG1691	(AIR) carboxylase
SAC12_RS09885	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SAC12_RS09890	COG1606	tRNA processing
SAC12_RS09900	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SAC12_RS09920	COG3842	ATPase activity
SAC12_RS09925	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAC12_RS09940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAC12_RS09945	COG0581	inorganic phosphate transmembrane transporter activity
SAC12_RS09950	COG0573	inorganic phosphate transmembrane transporter activity
SAC12_RS09990	COG1132	(ABC) transporter
SAC12_RS10005	COG2706	6-phosphogluconolactonase activity
SAC12_RS10015	COG0531	amino acid
SAC12_RS10030	COG0735	belongs to the Fur family
SAC12_RS10055	COG0589	response to stress
SAC12_RS10065	COG1846	Transcriptional regulator
SAC12_RS10070	COG3590	peptidase
SAC12_RS10095	COG2096	Adenosyltransferase
SAC12_RS10100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAC12_RS10110	COG1609	Transcriptional regulator
SAC12_RS10115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SAC12_RS10120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAC12_RS10125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAC12_RS10130	COG2190	(PTS) system
SAC12_RS10130	COG2211	Major facilitator Superfamily
SAC12_RS10145	COG2017	converts alpha-aldose to the beta-anomer
SAC12_RS10150	COG1960	acyl-CoA dehydrogenase activity
SAC12_RS10160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SAC12_RS10165	COG0604	alcohol dehydrogenase
SAC12_RS10170	COG0640	Transcriptional regulator
SAC12_RS10190	COG2814	Major facilitator Superfamily
SAC12_RS10195	COG0024	Methionine aminopeptidase
SAC12_RS10200	COG2226	methyltransferase
SAC12_RS10210	COG2094	Belongs to the DNA glycosylase MPG family
SAC12_RS10215	COG3189	MarR family transcriptional regulator
SAC12_RS10220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAC12_RS10235	COG0110	maltose O-acetyltransferase activity
SAC12_RS10245	COG0328	RNA-DNA hybrid ribonuclease activity
SAC12_RS10255	COG0402	S-adenosylhomocysteine deaminase activity
SAC12_RS10265	COG0351	phosphomethylpyrimidine kinase
SAC12_RS10275	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAC12_RS10295	COG1278	Cold shock
SAC12_RS10300	COG0400	carboxylic ester hydrolase activity
SAC12_RS10315	COG4166	transmembrane transport
SAC12_RS10335	COG0509	glycine decarboxylation via glycine cleavage system
SAC12_RS10340	COG0667	Aldo Keto reductase
SAC12_RS10350	COG0697	spore germination
SAC12_RS10355	COG2011	ABC-type metal ion transport system permease component
SAC12_RS10360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAC12_RS10365	COG1464	Belongs to the NlpA lipoprotein family
SAC12_RS10370	COG0519	Catalyzes the synthesis of GMP from XMP
SAC12_RS10375	COG4166	transmembrane transport
SAC12_RS10380	COG1472	Belongs to the glycosyl hydrolase 3 family
SAC12_RS10385	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SAC12_RS10390	COG0419	ATPase involved in DNA repair
SAC12_RS10395	COG0420	3'-5' exonuclease activity
SAC12_RS10400	COG2818	Glycosylase
SAC12_RS10420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAC12_RS10430	COG0789	Transcriptional regulator
SAC12_RS10435	COG1309	transcriptional regulator
SAC12_RS10455	COG2814	Major facilitator Superfamily
SAC12_RS10460	COG2814	Major facilitator Superfamily
SAC12_RS10465	COG1902	pentaerythritol trinitrate reductase activity
SAC12_RS10470	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SAC12_RS10515	COG0163	prenyltransferase activity
SAC12_RS10520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SAC12_RS10525	COG0583	DNA-binding transcription factor activity
SAC12_RS10530	COG0242	peptide deformylase activity
SAC12_RS10545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAC12_RS10550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SAC12_RS10555	COG1132	(ABC) transporter
SAC12_RS10560	COG1846	Transcriptional regulator
SAC12_RS10570	COG2801	Transposase and inactivated derivatives
SAC12_RS10600	COG1725	Transcriptional regulator
SAC12_RS10610	COG0386	Belongs to the glutathione peroxidase family
SAC12_RS10615	COG2814	Major facilitator Superfamily
SAC12_RS10620	COG0561	phosphatase activity
SAC12_RS10635	COG4221	oxidoreductase activity
SAC12_RS10640	COG1733	regulation of RNA biosynthetic process
SAC12_RS10645	COG1302	Protein conserved in bacteria
SAC12_RS10650	COG1302	Protein conserved in bacteria
SAC12_RS10665	COG2261	transglycosylase associated protein
SAC12_RS10680	COG0477	Major facilitator Superfamily
SAC12_RS10715	COG0436	Aminotransferase
SAC12_RS10725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAC12_RS10730	COG2235	arginine
SAC12_RS10735	COG1288	antiporter activity
SAC12_RS10740	COG2205	protein histidine kinase activity
SAC12_RS10745	COG0784	Response regulator, receiver
SAC12_RS10750	COG1288	antiporter activity
SAC12_RS10755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAC12_RS10780	COG2814	Major facilitator Superfamily
SAC12_RS10800	COG0588	phosphoglycerate mutase activity
SAC12_RS10810	COG0628	permease
SAC12_RS10815	COG1940	carbohydrate kinase activity
SAC12_RS10815	COG1846	Transcriptional regulator
SAC12_RS10825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAC12_RS10855	COG1511	domain protein
SAC12_RS10855	COG1511	domain protein
SAC12_RS10860	COG1686	Belongs to the peptidase S11 family
SAC12_RS10875	COG0517	IMP dehydrogenase activity
SAC12_RS10875	COG0516	GMP reductase activity
SAC12_RS10890	COG0012	GTP binding
SAC12_RS10895	COG4481	Protein conserved in bacteria
SAC12_RS10900	COG1475	DNA binding
SAC12_RS10905	COG1192	Involved in chromosome partitioning
SAC12_RS10915	COG0357	Ribosomal RNA small subunit methyltransferase G
SAC12_RS10935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SAC12_RS10945	COG0702	epimerase
SAC12_RS10995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAC12_RS11035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAC12_RS11045	COG0352	thiamine-phosphate diphosphorylase activity
SAC12_RS11050	COG0351	phosphomethylpyrimidine kinase
SAC12_RS11055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SAC12_RS11060	COG0300	oxidoreductase activity
SAC12_RS11065	COG0390	transport system, permease component
SAC12_RS11070	COG4619	ABC transporter
SAC12_RS11075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAC12_RS11130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SAC12_RS11135	COG1418	mRNA catabolic process
SAC12_RS11155	COG1396	sequence-specific DNA binding
SAC12_RS11170	COG1114	Component of the transport system for branched-chain amino acids
SAC12_RS11180	COG0531	amino acid
SAC12_RS11185	COG1114	Component of the transport system for branched-chain amino acids
SAC12_RS11220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SAC12_RS11235	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SAC12_RS11245	COG2801	Transposase and inactivated derivatives
SAC12_RS11255	COG2244	polysaccharide biosynthetic process
SAC12_RS11260	COG1476	TRANSCRIPTIONal
SAC12_RS11265	COG0823	Involved in the tonB-independent uptake of proteins
SAC12_RS11265	COG4946	Tricorn protease homolog
SAC12_RS11265	COG1506	peptidase
SAC12_RS11270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAC12_RS11280	COG1393	Belongs to the ArsC family
SAC12_RS11285	COG0025	NhaP-type Na H and K H
SAC12_RS11290	COG0737	Belongs to the 5'-nucleotidase family
SAC12_RS11315	COG1609	Transcriptional regulator
SAC12_RS11325	COG4475	Protein of unknown function (DUF436)
SAC12_RS11335	COG0351	phosphomethylpyrimidine kinase
SAC12_RS11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAC12_RS11345	COG1316	TRANSCRIPTIONal
SAC12_RS11360	COG0772	Belongs to the SEDS family
SAC12_RS11390	COG1940	carbohydrate kinase activity
SAC12_RS11405	COG2076	Multidrug Resistance protein
SAC12_RS11410	COG2076	Multidrug Resistance protein
SAC12_RS11455	COG4166	transmembrane transport
SAC12_RS11470	COG1609	Transcriptional regulator
SAC12_RS11480	COG0366	Alpha amylase catalytic
SAC12_RS11500	COG1902	pentaerythritol trinitrate reductase activity
SAC12_RS11510	COG1733	regulation of RNA biosynthetic process
SAC12_RS11525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAC12_RS11555	COG1881	PFAM PEBP family protein
SAC12_RS11570	COG0577	efflux transmembrane transporter activity
SAC12_RS11580	COG2814	Major facilitator Superfamily
SAC12_RS11595	COG0281	malic enzyme
SAC12_RS11600	COG0583	DNA-binding transcription factor activity
SAC12_RS11620	COG2957	Belongs to the agmatine deiminase family
SAC12_RS11625	COG0531	amino acid
SAC12_RS11630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAC12_RS11635	COG1757	Na H antiporter
SAC12_RS11640	COG0531	amino acid
SAC12_RS11665	COG0183	Belongs to the thiolase family
SAC12_RS11690	COG2261	transglycosylase associated protein
SAC12_RS11700	COG2207	Transcriptional regulator
SAC12_RS11710	COG3022	response to hydroperoxide
SAC12_RS11715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAC12_RS11720	COG0284	orotidine-5'-phosphate decarboxylase activity
SAC12_RS11725	COG2814	Major facilitator Superfamily
SAC12_RS11735	COG2267	carboxylic ester hydrolase activity
SAC12_RS11740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAC12_RS11750	COG1397	ADP-ribosylglycohydrolase
SAC12_RS11755	COG2188	Transcriptional regulator
SAC12_RS11760	COG4335	DNA alkylation repair
SAC12_RS11775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAC12_RS11795	COG0110	maltose O-acetyltransferase activity
SAC12_RS11835	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS11865	COG3842	ATPase activity
SAC12_RS11875	COG3250	beta-galactosidase activity
SAC12_RS11880	COG1959	2 iron, 2 sulfur cluster binding
SAC12_RS11885	COG0702	epimerase
SAC12_RS11905	COG1917	Cupin 2, conserved barrel domain protein
SAC12_RS11905	COG4977	sequence-specific DNA binding
SAC12_RS11915	COG1074	ATP-dependent DNA helicase activity
SAC12_RS11920	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SAC12_RS11925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAC12_RS11930	COG0726	polysaccharide deacetylase
SAC12_RS11945	COG0667	Aldo Keto reductase
SAC12_RS11950	COG2252	PERMEase
SAC12_RS11955	COG1846	Transcriptional regulator
SAC12_RS11975	COG4485	Bacterial membrane protein, YfhO
SAC12_RS12005	COG2211	Major facilitator Superfamily
SAC12_RS12010	COG2207	Transcriptional regulator
SAC12_RS12065	COG2814	Major facilitator Superfamily
SAC12_RS12075	COG1607	acyl-coa hydrolase
SAC12_RS12080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAC12_RS12090	COG1114	Component of the transport system for branched-chain amino acids
SAC12_RS12100	COG1011	Hydrolase
SAC12_RS12115	COG0445	tRNA wobble uridine modification
SAC12_RS12120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SAC12_RS12130	COG0706	membrane insertase activity
SAC12_RS12135	COG0594	ribonuclease P activity
SAC12_RS12140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAC12_RS12190	COG0589	response to stress
SAC12_RS12235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAC12_RS12245	COG1192	Involved in chromosome partitioning
SAC12_RS12260	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS12270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SAC12_RS12275	COG2252	PERMEase
SAC12_RS12280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAC12_RS12295	COG0028	Belongs to the TPP enzyme family
SAC12_RS12310	COG2814	Major facilitator Superfamily
SAC12_RS12315	COG5039	Polysaccharide pyruvyl transferase
SAC12_RS12320	COG2814	Major facilitator Superfamily
SAC12_RS12330	COG4876	unkown
SAC12_RS12345	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAC12_RS12370	COG3328	transposase activity
SAC12_RS12405	COG3158	transport of potassium into the cell
SAC12_RS12445	COG2826	transposase and inactivated derivatives, IS30 family
SAC12_RS12475	COG1192	Involved in chromosome partitioning
SAC12_RS12510	COG2814	Major facilitator Superfamily
SAC12_RS12525	COG1285	pathogenesis