locus-tag	class	description
E6A57_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E6A57_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E6A57_RS00015	ENOG410848D	S4 domain protein YaaA
E6A57_RS00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E6A57_RS00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E6A57_RS00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E6A57_RS00035	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E6A57_RS00040	ENOG4108UUM	single-stranded DNA-binding protein
E6A57_RS00045	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E6A57_RS00055	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E6A57_RS00060	ENOG4105CDU	Replicative dna helicase
E6A57_RS00075	ENOG4105EVU	fructokinase
E6A57_RS00085	ENOG4107BMA	Transglycosylase associated protein
E6A57_RS00095	ENOG4105KT7	mgtC SapB transporter
E6A57_RS00150	ENOG4106F5Q	Membrane
E6A57_RS00200	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E6A57_RS00220	ENOG4107RX3	Mg2 transporter protein cora family protein
E6A57_RS00235	ENOG4108HCJ	Hydrolase
E6A57_RS00240	ENOG4105C5I	Dehydrogenase
E6A57_RS00255	ENOG4105CGK	Exodeoxyribonuclease III
E6A57_RS00260	ENOG4105E5D	amino acid
E6A57_RS00330	ENOG4105X1N	Glycosyl transferase family 8
E6A57_RS00340	ENOG4105X1N	Glycosyl transferase family 8
E6A57_RS00365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E6A57_RS00370	ENOG4105BZU	Histidine kinase
E6A57_RS00385	ENOG4105Q2H	domain protein
E6A57_RS00390	ENOG4105C0H	protease
E6A57_RS00395	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E6A57_RS00405	ENOG4107RCM	Releases the N-terminal proline from various substrates (By similarity)
E6A57_RS00415	ENOG4108JJB	ABC transporter
E6A57_RS00440	ENOG4105D0M	Protease HtpX homolog
E6A57_RS00445	ENOG4108V0P	LemA family
E6A57_RS00450	ENOG4105F4P	)-transporter
E6A57_RS00475	ENOG4107R8N	Glycosyl transferase, family 2
E6A57_RS00495	ENOG4105KAF	membrAne
E6A57_RS00500	ENOG4105CDA	abc transporter atp-binding protein
E6A57_RS00505	ENOG4105E5Q	amino acid AbC transporter
E6A57_RS00510	ENOG4108VX5	3-methyladenine DNA glycosylase
E6A57_RS00515	ENOG4105K78	MarR family Transcriptional regulator
E6A57_RS00520	ENOG4107TS3	membrane protein, TerC
E6A57_RS00530	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E6A57_RS00540	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E6A57_RS00550	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E6A57_RS00560	ENOG4105K64	Glycosyl transferase, family 2
E6A57_RS00575	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E6A57_RS00590	ENOG4105E5Q	amino acid AbC transporter
E6A57_RS00595	ENOG4105CDA	abc transporter atp-binding protein
E6A57_RS00605	ENOG4105CPF	Cell wall formation (By similarity)
E6A57_RS00635	ENOG4105CE4	GlcNAc 6-P deacetylase
E6A57_RS00675	ENOG4105CIG	ABC transporter
E6A57_RS00705	ENOG4105M2Z	protein tyrosine serine phosphatase
E6A57_RS00710	ENOG4107YZX	Universal stress protein
E6A57_RS00720	ENOG4105D5T	phosphonate abc transporter
E6A57_RS00730	ENOG4105S7S	phosphonate abc transporter
E6A57_RS00735	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E6A57_RS00750	ENOG4105CAQ	asparagine synthetase
E6A57_RS00760	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
E6A57_RS00765	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
E6A57_RS00770	ENOG4105VG1	fes assembly suf system protein
E6A57_RS00780	ENOG410605W	Major Facilitator
E6A57_RS00785	ENOG4105C9K	Endothelin-converting enzyme 1
E6A57_RS00790	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E6A57_RS00840	ENOG4105CB5	ATP-dependent DNA helicase recG
E6A57_RS00905	ENOG4105NA0	Transcriptional regulator
E6A57_RS00940	ENOG410907Z	n-acetylmuramoyl-l-alanine amidase
E6A57_RS00950	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
E6A57_RS00955	ENOG4105EE0	oxidoreductase
E6A57_RS00970	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E6A57_RS00980	ENOG4108KGH	TRANSCRIPTIONal
E6A57_RS00985	ENOG41061BS	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E6A57_RS00990	ENOG4107T7U	Sulfatase
E6A57_RS00995	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E6A57_RS01010	ENOG4105CTZ	aminopeptidase c
E6A57_RS01020	ENOG4108J59	Extracellular solute-binding protein, family 5
E6A57_RS01030	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E6A57_RS01035	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E6A57_RS01040	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E6A57_RS01050	ENOG4108JQ7	(ABC) transporter
E6A57_RS01055	ENOG4105CTZ	aminopeptidase c
E6A57_RS01065	ENOG4105KP9	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E6A57_RS01090	ENOG4108UK2	deaminase
E6A57_RS01100	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
E6A57_RS01115	ENOG4105BZ1	(ABC) transporter
E6A57_RS01120	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E6A57_RS01125	ENOG4105F8V	Hydrolase, tatD family
E6A57_RS01135	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E6A57_RS01140	ENOG4105W42	Veg protein
E6A57_RS01145	ENOG4105DFT	pur operon repressor
E6A57_RS01150	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E6A57_RS01165	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E6A57_RS01180	ENOG4105DCI	Phosphohydrolase
E6A57_RS01190	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
E6A57_RS01195	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E6A57_RS01200	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E6A57_RS01210	ENOG4105DZW	Dipeptidase
E6A57_RS01215	ENOG4108R6W	Transcriptional regulator, ARAC family
E6A57_RS01220	ENOG4105C2W	permease
E6A57_RS01225	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
E6A57_RS01235	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E6A57_RS01265	ENOG4105D7V	transposase
E6A57_RS01280	ENOG4105KVH	Transcriptional regulator
E6A57_RS01285	ENOG4105CIS	alcohol dehydrogenase
E6A57_RS01295	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E6A57_RS01330	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E6A57_RS01335	ENOG4107QTZ	amino acid
E6A57_RS01340	ENOG4108HCJ	Hydrolase
E6A57_RS01345	ENOG4105CG3	alpha amylase, catalytic region
E6A57_RS01350	ENOG41082DI	50s ribosomal protein l31
E6A57_RS01355	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
E6A57_RS01360	ENOG4105C1J	atp-dependent rna helicase
E6A57_RS01365	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E6A57_RS01370	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E6A57_RS01380	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E6A57_RS01385	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E6A57_RS01390	ENOG4108JA2	transcriptioN-repair coupling factor
E6A57_RS01395	ENOG41082I2	s4 domain protein
E6A57_RS01405	ENOG4107QUF	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E6A57_RS01410	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E6A57_RS01420	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E6A57_RS01425	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E6A57_RS01430	ENOG4105CRK	lysyL-tRNA synthetase
E6A57_RS01470	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E6A57_RS01475	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E6A57_RS01480	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E6A57_RS01485	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
E6A57_RS01490	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E6A57_RS01495	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E6A57_RS01500	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E6A57_RS01505	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E6A57_RS01510	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E6A57_RS01515	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E6A57_RS01520	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E6A57_RS01525	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E6A57_RS01535	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E6A57_RS01540	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E6A57_RS01545	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E6A57_RS01550	ENOG41082SA	50s ribosomal protein l29
E6A57_RS01555	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E6A57_RS01560	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E6A57_RS01565	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E6A57_RS01570	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E6A57_RS01575	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E6A57_RS01580	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E6A57_RS01585	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E6A57_RS01590	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E6A57_RS01595	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E6A57_RS01600	ENOG4105VPB	50S ribosomal protein L30
E6A57_RS01605	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E6A57_RS01610	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E6A57_RS01615	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E6A57_RS01620	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E6A57_RS01625	ENOG41067V7	50S ribosomal protein L36
E6A57_RS01630	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E6A57_RS01635	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E6A57_RS01640	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E6A57_RS01645	ENOG4108ZT0	50S ribosomal protein l17
E6A57_RS01650	ENOG4108JJB	ABC transporter
E6A57_RS01655	ENOG4108JJB	ABC transporter
E6A57_RS01660	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
E6A57_RS01665	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E6A57_RS01670	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E6A57_RS01675	ENOG4108UJD	30S ribosomal protein S9
E6A57_RS01685	ENOG41083J0	(ABC) transporter
E6A57_RS01690	ENOG4105C4B	ABC transporter, permease
E6A57_RS01720	ENOG4105PGM	cation diffusion facilitator family transporter
E6A57_RS01730	ENOG4108K79	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E6A57_RS01740	ENOG4105CTZ	aminopeptidase c
E6A57_RS01750	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E6A57_RS01760	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E6A57_RS01765	ENOG4105C8N	cysteinyl-tRNA synthetase
E6A57_RS01770	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E6A57_RS01775	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E6A57_RS01790	ENOG4105CMG	Carbohydrate kinase
E6A57_RS01795	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E6A57_RS01800	ENOG4107FTN	50S ribosomal protein L33
E6A57_RS01810	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E6A57_RS01815	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E6A57_RS01820	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E6A57_RS01825	ENOG4105CVA	phosphate
E6A57_RS01830	ENOG4105C8U	phosphate abc transporter
E6A57_RS01835	ENOG4105E2Z	phosphate ABC transporter (Permease
E6A57_RS01840	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E6A57_RS01845	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E6A57_RS01850	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
E6A57_RS01865	ENOG4108VZM	50s ribosomal protein L10
E6A57_RS01870	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E6A57_RS01880	ENOG4107Y49	methyltransferase
E6A57_RS01890	ENOG4108Z6B	deaminase
E6A57_RS01900	ENOG4105C6E	dna polymerase iii
E6A57_RS01915	ENOG4107Q1J	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E6A57_RS01920	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E6A57_RS01930	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E6A57_RS01935	ENOG4105X0R	protein from nitrogen regulatory protein P-II
E6A57_RS01945	ENOG4105QD5	Involved in initiation control of chromosome replication (By similarity)
E6A57_RS01950	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E6A57_RS01960	ENOG4105X71	Membrane
E6A57_RS01965	ENOG41072GX	Peptidase M22 Glycoprotease
E6A57_RS01975	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E6A57_RS01990	ENOG4105C5H	ABC transporter
E6A57_RS01995	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
E6A57_RS02000	ENOG4105ETE	Transcriptional regulator (LacI family
E6A57_RS02005	ENOG4108HKT	sucrose-6-phosphate hydrolase
E6A57_RS02010	ENOG4105C5Y	PTS System
E6A57_RS02025	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E6A57_RS02030	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E6A57_RS02035	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E6A57_RS02040	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E6A57_RS02045	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E6A57_RS02050	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E6A57_RS02060	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E6A57_RS02065	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E6A57_RS02070	ENOG4105SFS	phosphoesterase RecJ domain protein
E6A57_RS02075	ENOG4105C1J	atp-dependent rna helicase
E6A57_RS02080	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E6A57_RS02085	ENOG4105VBH	UPF0297 protein
E6A57_RS02090	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E6A57_RS02095	ENOG4105VPH	UPF0473 protein
E6A57_RS02100	ENOG4105C98	muts2 protein
E6A57_RS02105	ENOG4105K63	Thioredoxin
E6A57_RS02110	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E6A57_RS02120	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E6A57_RS02125	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E6A57_RS02130	ENOG4105D8X	mechanosensitive ion channel
E6A57_RS02145	ENOG4105DC7	peptidase M24
E6A57_RS02165	ENOG4107R8B	5'-nucleotidase
E6A57_RS02175	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
E6A57_RS02185	ENOG4105DQR	SNARE associated Golgi
E6A57_RS02190	ENOG4105CAY	ferredoxin--nadp reductase
E6A57_RS02355	ENOG4105BZF	Glycosyl transferase (Group 1
E6A57_RS02360	ENOG4105W2C	Glycosyl transferase
E6A57_RS02370	ENOG4105E0M	Sulfatase
E6A57_RS02375	ENOG4105XZU	Preprotein translocase, subunit SecG
E6A57_RS02380	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E6A57_RS02385	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E6A57_RS02445	ENOG4105ETZ	PTS System
E6A57_RS02450	ENOG4105F3R	pts system mannose fructose sorbose family iid
E6A57_RS02460	ENOG4105DUM	transcriptional regulator, lysR family
E6A57_RS02465	ENOG4108UW5	maltose o-acetyltransferase
E6A57_RS02470	ENOG4105C85	amino acid
E6A57_RS02475	ENOG4108EKI	Dehydrogenase
E6A57_RS02480	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E6A57_RS02495	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E6A57_RS02500	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E6A57_RS02515	ENOG4108I5C	dEAD DEAH box helicase
E6A57_RS02525	ENOG4108DBC	nitroreductase
E6A57_RS02540	ENOG4108UW5	maltose o-acetyltransferase
E6A57_RS02570	ENOG4105CK1	PTS System
E6A57_RS02570	ENOG4105CK1	PTS System
E6A57_RS02585	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E6A57_RS02605	ENOG4105ETE	Transcriptional regulator (LacI family
E6A57_RS02615	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
E6A57_RS02620	ENOG4105DRS	transport system, permease
E6A57_RS02630	ENOG4108IJ9	(ABC) transporter
E6A57_RS02635	ENOG4107RK0	Sucrose phosphorylase
E6A57_RS02645	ENOG4105CHM	Aminotransferase
E6A57_RS02655	ENOG4105E66	phosphoriboisomerase A
E6A57_RS02660	ENOG4105QEK	Transcriptional regulator
E6A57_RS02670	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E6A57_RS02695	ENOG4105FDP	GntR family transcriptional regulator
E6A57_RS02715	ENOG4105DAP	Nicotinate phosphoribosyltransferase
E6A57_RS02720	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
E6A57_RS02745	ENOG410906U	SprT-like
E6A57_RS02755	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
E6A57_RS02760	ENOG4105C4R	Atp-dependent dna helicase
E6A57_RS02765	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E6A57_RS02775	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E6A57_RS02780	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E6A57_RS02785	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E6A57_RS02790	ENOG4105CBD	Diacylglycerol kinase
E6A57_RS02795	ENOG4105HFZ	Membrane
E6A57_RS02810	ENOG4105DFD	Na H antiporter
E6A57_RS02820	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E6A57_RS02860	ENOG4105CCI	Myosin-Cross-Reactive Antigen
E6A57_RS02890	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
E6A57_RS02895	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E6A57_RS02920	ENOG4105C5H	ABC transporter
E6A57_RS02925	ENOG4107QM2	Aldo Keto reductase
E6A57_RS02935	ENOG4107R7I	amino acid
E6A57_RS02940	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E6A57_RS02945	ENOG4105CT1	(ABC) transporter
E6A57_RS02955	ENOG4105BZ1	(ABC) transporter
E6A57_RS02960	ENOG4105BZ1	(ABC) transporter
E6A57_RS02975	ENOG4105DBI	uridine monophosphokinase
E6A57_RS02985	ENOG4105CT1	(ABC) transporter
E6A57_RS02990	ENOG4105EAD	ABC transporter
E6A57_RS02995	ENOG4105DRP	amino acid AbC transporter
E6A57_RS03030	ENOG4105E66	phosphoriboisomerase A
E6A57_RS03035	ENOG4105DFH	Transport of potassium into the cell (By similarity)
E6A57_RS03045	ENOG4108TZY	GntR Family Transcriptional Regulator
E6A57_RS03050	ENOG4108HCJ	Hydrolase
E6A57_RS03065	ENOG4107QRI	Phosphoketolase
E6A57_RS03075	ENOG410667J	hydrolase
E6A57_RS03080	ENOG4105CI1	PTS System
E6A57_RS03085	ENOG4106KNT	transcriptional regulator
E6A57_RS03095	ENOG4105CI1	PTS System
E6A57_RS03110	ENOG4105C37	(CBS) domain
E6A57_RS03120	ENOG4107EFR	Flavocytochrome c
E6A57_RS03135	ENOG4107R7I	amino acid
E6A57_RS03150	ENOG4105CK1	PTS System
E6A57_RS03165	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
E6A57_RS03175	ENOG4105NQC	Flavodoxin
E6A57_RS03180	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E6A57_RS03185	ENOG4107U9T	Pfam:Ribonuclease_BN
E6A57_RS03190	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E6A57_RS03195	ENOG4105CHU	acetyl-coa acetyltransferase
E6A57_RS03205	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
E6A57_RS03220	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E6A57_RS03225	ENOG410902V	Modulates RecA activity (By similarity)
E6A57_RS03240	ENOG4108JU5	Magnesium and cobalt efflux protein
E6A57_RS03245	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E6A57_RS03255	ENOG4105BZ1	(ABC) transporter
E6A57_RS03305	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E6A57_RS03315	ENOG4105KRI	phosphocarrier protein (HPr
E6A57_RS03320	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
E6A57_RS03325	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
E6A57_RS03355	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E6A57_RS03360	ENOG4105EMS	pseudouridine synthase
E6A57_RS03375	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E6A57_RS03390	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E6A57_RS03400	ENOG4105CNU	cell division protein FtsK
E6A57_RS03415	ENOG4105CHR	reductase
E6A57_RS03425	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E6A57_RS03430	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E6A57_RS03435	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
E6A57_RS03440	ENOG4105ESV	Glycosyl transferase, family 4
E6A57_RS03445	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E6A57_RS03465	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E6A57_RS03480	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
E6A57_RS03485	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E6A57_RS03490	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E6A57_RS03495	ENOG4105C3M	thioredoxin reductase
E6A57_RS03505	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E6A57_RS03510	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E6A57_RS03520	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E6A57_RS03525	ENOG4105CHW	UPF0052 protein
E6A57_RS03530	ENOG4105CIE	May be required for sporulation (By similarity)
E6A57_RS03535	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E6A57_RS03545	ENOG41083J0	(ABC) transporter
E6A57_RS03550	ENOG4105C4B	ABC transporter, permease
E6A57_RS03575	ENOG4105E5D	amino acid
E6A57_RS03595	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E6A57_RS03600	ENOG4105BZA	Phosphoglycerate kinase
E6A57_RS03605	ENOG4105CP7	Triose-phosphate isomerase
E6A57_RS03615	ENOG410667J	hydrolase
E6A57_RS03620	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E6A57_RS03625	ENOG4108IJ2	phosphate acetyltransferase
E6A57_RS03630	ENOG4105K8N	protein family UPF0079, ATPase
E6A57_RS03640	ENOG4105D4A	Cell wall formation (By similarity)
E6A57_RS03645	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E6A57_RS03650	ENOG4105F38	ABC transporter, permease
E6A57_RS03670	ENOG4107U5W	ybbr family
E6A57_RS03675	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E6A57_RS03680	ENOG410667J	hydrolase
E6A57_RS03685	ENOG4105NA0	Transcriptional regulator
E6A57_RS03695	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
E6A57_RS03700	ENOG4105BZW	Glycerate kinase
E6A57_RS03710	ENOG4105C5Y	PTS System
E6A57_RS03725	ENOG4105E5D	amino acid
E6A57_RS03730	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E6A57_RS03745	ENOG4105CDY	transcriptional regulatory protein
E6A57_RS03800	ENOG4105C87	Aminotransferase class I and II
E6A57_RS03805	ENOG4105DG6	mannose-6-phosphate isomerase
E6A57_RS03815	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E6A57_RS03820	ENOG4105BZU	Histidine kinase
E6A57_RS03835	ENOG4107QYV	phosphohexose isomerase
E6A57_RS03840	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E6A57_RS03860	ENOG4105DMS	mur ligase
E6A57_RS03865	ENOG4107104	thymidine kinase
E6A57_RS03870	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E6A57_RS03875	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E6A57_RS03880	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E6A57_RS03885	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E6A57_RS03895	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E6A57_RS03900	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
E6A57_RS03905	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E6A57_RS03910	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E6A57_RS03915	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E6A57_RS03920	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E6A57_RS03925	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E6A57_RS03940	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E6A57_RS03990	ENOG4107YZX	Universal stress protein
E6A57_RS04000	ENOG4105D1H	recombination factor protein RarA
E6A57_RS04010	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E6A57_RS04015	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
E6A57_RS04020	ENOG4105C3J	Cysteine desulfurase
E6A57_RS04025	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E6A57_RS04065	ENOG4105D5G	Transposase
E6A57_RS04105	ENOG4105CKK	Glycosyl transferase, family 2
E6A57_RS04125	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
E6A57_RS04145	ENOG4107QMH	DNA methylase
E6A57_RS04160	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E6A57_RS04185	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E6A57_RS04195	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
E6A57_RS04200	ENOG4105W5Q	DNA repair protein (RadC
E6A57_RS04205	ENOG4105DFF	Rod shape-determining protein mreb
E6A57_RS04210	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E6A57_RS04230	ENOG4108V6E	Cell division protein mraZ
E6A57_RS04235	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E6A57_RS04245	ENOG4105CJN	penicillin-binding protein
E6A57_RS04250	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E6A57_RS04255	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E6A57_RS04260	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E6A57_RS04265	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
E6A57_RS04275	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E6A57_RS04280	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
E6A57_RS04295	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
E6A57_RS04300	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E6A57_RS04305	ENOG4105VEQ	Cold shock protein
E6A57_RS04310	ENOG4108YZ4	nudix hydrolase
E6A57_RS04325	ENOG4105C3J	Cysteine desulfurase
E6A57_RS04335	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E6A57_RS04340	ENOG4105CVJ	phosphoglycerate mutase
E6A57_RS04350	ENOG4105C7H	Helicase, RecD TraA family
E6A57_RS04370	ENOG4106EHS	UPF0356 protein
E6A57_RS04380	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E6A57_RS04385	ENOG4105CI3	gtp-binding protein typa
E6A57_RS04390	ENOG4105CNI	cell division protein FtsW
E6A57_RS04395	ENOG4105WUC	UPF0298 protein
E6A57_RS04400	ENOG4106H78	methyltransferase
E6A57_RS04405	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E6A57_RS04410	ENOG41063PX	domain protein
E6A57_RS04415	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
E6A57_RS04420	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
E6A57_RS04425	ENOG4105TQK	DNA polymerase iii, delta' subunit
E6A57_RS04430	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E6A57_RS04435	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E6A57_RS04450	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E6A57_RS04455	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E6A57_RS04460	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E6A57_RS04465	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E6A57_RS04475	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E6A57_RS04480	ENOG4105CFH	Aspartokinase
E6A57_RS04485	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E6A57_RS04490	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E6A57_RS04495	ENOG4105CH2	amidohydrolase
E6A57_RS04500	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E6A57_RS04505	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E6A57_RS04510	ENOG4105CHM	Aminotransferase
E6A57_RS04515	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E6A57_RS04520	ENOG4105FQP	Beta-lactamase
E6A57_RS04530	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E6A57_RS04540	ENOG4105DU0	nucleoside hydrolase
E6A57_RS04550	ENOG4105CS2	ec 3.2.1.21
E6A57_RS04555	ENOG4108S3Y	transcriptional regulator
E6A57_RS04560	ENOG4105VZJ	PTS System
E6A57_RS04565	ENOG4105VCP	PTS System
E6A57_RS04575	ENOG4105CS2	ec 3.2.1.21
E6A57_RS04580	ENOG4108TZY	GntR Family Transcriptional Regulator
E6A57_RS04590	ENOG4105CK1	PTS System
E6A57_RS04595	ENOG4105CS2	ec 3.2.1.21
E6A57_RS04615	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E6A57_RS04630	ENOG4107QHE	Choloylglycine hydrolase
E6A57_RS04640	ENOG4105HMI	Membrane
E6A57_RS04645	ENOG4105HUF	DNA protection during starvation protein
E6A57_RS04670	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E6A57_RS04700	ENOG4107R8N	Glycosyl transferase, family 2
E6A57_RS04705	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
E6A57_RS04725	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E6A57_RS04730	ENOG4108R6K	riboflavin synthase, subunit alpha
E6A57_RS04735	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E6A57_RS04740	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
E6A57_RS04755	ENOG4105ETT	transcriptional Regulator, LysR family
E6A57_RS04765	ENOG4105C5H	ABC transporter
E6A57_RS04785	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
E6A57_RS04795	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
E6A57_RS04830	ENOG4105WV0	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
E6A57_RS04845	ENOG4105BZ1	(ABC) transporter
E6A57_RS04855	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E6A57_RS04860	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
E6A57_RS04865	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
E6A57_RS04875	ENOG4105D01	(LipO)protein
E6A57_RS04880	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E6A57_RS04885	ENOG4108UMI	ABC transporter, permease
E6A57_RS04890	ENOG4105C9Q	fumarate hydratase class II
E6A57_RS04895	ENOG4107EFR	Flavocytochrome c
E6A57_RS04900	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E6A57_RS04905	ENOG4105CTZ	aminopeptidase c
E6A57_RS04910	ENOG4105JSC	dimethylmenaquinone methyltransferase
E6A57_RS04915	ENOG4107QPK	)-transporter
E6A57_RS04920	ENOG4107S9D	Alpha beta hydrolase
E6A57_RS04930	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
E6A57_RS04945	ENOG4108VMM	UPF0756 membrane protein
E6A57_RS04955	ENOG4108JJB	ABC transporter
E6A57_RS04960	ENOG4108V7D	UPF0397 protein
E6A57_RS04985	ENOG4108Z66	YbaK ebsC protein
E6A57_RS04990	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E6A57_RS05000	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E6A57_RS05005	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E6A57_RS05010	ENOG4105CUT	histidyl-tRNA synthetase
E6A57_RS05015	ENOG4105C9M	aspartyl-trna synthetase
E6A57_RS05020	ENOG4105CHM	Aminotransferase
E6A57_RS05030	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E6A57_RS05035	ENOG4105CV8	reductase
E6A57_RS05040	ENOG410667J	hydrolase
E6A57_RS05045	ENOG4105C5I	Dehydrogenase
E6A57_RS05050	ENOG4105CUB	amino acid
E6A57_RS05055	ENOG4107T5V	SNARE associated Golgi
E6A57_RS05060	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E6A57_RS05065	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E6A57_RS05070	ENOG4105EXC	Acyl-transferase
E6A57_RS05075	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
E6A57_RS05080	ENOG4108IXY	short-chain dehydrogenase reductase
E6A57_RS05090	ENOG41086FC	50S ribosomal protein l32
E6A57_RS05095	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
E6A57_RS05105	ENOG4105C0B	DNA polymerase III (alpha subunit)
E6A57_RS05110	ENOG4105CTQ	phosphohexokinase
E6A57_RS05115	ENOG4105CA9	Pyruvate kinase
E6A57_RS05120	ENOG4105QNR	S1 RNA binding domain protein
E6A57_RS05135	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
E6A57_RS05140	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E6A57_RS05145	ENOG4105FE9	pseudouridine synthase
E6A57_RS05150	ENOG4108SAX	Membrane
E6A57_RS05160	ENOG4105CAT	Cytidine monophosphate kinase
E6A57_RS05165	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E6A57_RS05170	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E6A57_RS05175	ENOG4105K70	DNA-binding protein
E6A57_RS05190	ENOG4105BZ1	(ABC) transporter
E6A57_RS05230	ENOG4105M2Z	protein tyrosine serine phosphatase
E6A57_RS05265	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
E6A57_RS05295	ENOG4105D5Q	Arginine ornithine antiporter
E6A57_RS05305	ENOG4108JYZ	YitT family
E6A57_RS05310	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E6A57_RS05315	ENOG4108UT2	hemolysin iii
E6A57_RS05320	ENOG4108RCR	degv family
E6A57_RS05325	ENOG4106E6V	UPF0346 protein
E6A57_RS05335	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E6A57_RS05340	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E6A57_RS05345	ENOG4105C79	DNA protecting protein DprA
E6A57_RS05350	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E6A57_RS05355	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
E6A57_RS05360	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E6A57_RS05370	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E6A57_RS05395	ENOG41083GQ	Protein CrcB homolog
E6A57_RS05400	ENOG4106A8V	Protein CrcB homolog
E6A57_RS05410	ENOG4108IQI	permease
E6A57_RS05425	ENOG4105E5D	amino acid
E6A57_RS05435	ENOG4105CXI	aluminum resistance protein
E6A57_RS05440	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E6A57_RS05480	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E6A57_RS05485	ENOG4108J5H	Homocysteine s-methyltransferase
E6A57_RS05510	ENOG4108UW5	maltose o-acetyltransferase
E6A57_RS05540	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E6A57_RS05545	ENOG4105D1H	recombination factor protein RarA
E6A57_RS05550	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
E6A57_RS05595	ENOG4105DZR	Type I site-specific deoxyribonuclease
E6A57_RS05615	ENOG4105D5G	Transposase
E6A57_RS05685	ENOG4105CKU	formyltetrahydrofolate synthetase
E6A57_RS05690	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E6A57_RS05695	ENOG4105C34	Pseudouridine synthase
E6A57_RS05700	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E6A57_RS05705	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E6A57_RS05710	ENOG4105F23	Fibronectin-binding protein
E6A57_RS05720	ENOG4105EPR	degv family
E6A57_RS05725	ENOG4105C98	muts2 protein
E6A57_RS05770	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
E6A57_RS05780	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E6A57_RS05785	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E6A57_RS05790	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E6A57_RS05835	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E6A57_RS05850	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E6A57_RS05860	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
E6A57_RS05865	ENOG4108UKS	UPF0398 protein
E6A57_RS05870	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
E6A57_RS05875	ENOG4105BZ4	penicillin-binding protein
E6A57_RS05880	ENOG4105CSM	endonuclease III
E6A57_RS05890	ENOG4105C5S	asparaginyl-tRNA synthetase
E6A57_RS05905	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E6A57_RS05910	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E6A57_RS05930	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
E6A57_RS05935	ENOG4108HCJ	Hydrolase
E6A57_RS05940	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E6A57_RS05955	ENOG4105C3F	Signal peptidase i
E6A57_RS05980	ENOG4105CZV	ABC transporter
E6A57_RS05985	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
E6A57_RS05990	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E6A57_RS05995	ENOG4105EGD	dinuclear metal center protein, YbgI family
E6A57_RS06015	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E6A57_RS06020	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E6A57_RS06025	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E6A57_RS06030	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
E6A57_RS06035	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
E6A57_RS06040	ENOG4105D7V	transposase
E6A57_RS06050	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E6A57_RS06055	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E6A57_RS06060	ENOG4105C9A	Phoh family
E6A57_RS06070	ENOG4105VCC	30S ribosomal protein S21
E6A57_RS06075	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E6A57_RS06125	ENOG4105IJJ	transcriptional regulator, crp fnr family
E6A57_RS06135	ENOG4105C59	p-type ATPase
E6A57_RS06160	ENOG4107AYK	membrAne
E6A57_RS06350	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
E6A57_RS06355	ENOG4105D6E	homoserine dehydrogenase
E6A57_RS06360	ENOG4105D98	threonine synthase
E6A57_RS06365	ENOG4105CFH	Aspartokinase
E6A57_RS06395	ENOG4105BZ1	(ABC) transporter
E6A57_RS06435	ENOG4105DBV	ornithine carbamoyltransferase
E6A57_RS06450	ENOG4106P55	Transcriptional regulator
E6A57_RS06475	ENOG4107QN2	dihydrolipoyl dehydrogenase
E6A57_RS06485	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E6A57_RS06490	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E6A57_RS06495	ENOG4108Z6X	(sortase) family
E6A57_RS06500	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E6A57_RS06510	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E6A57_RS06515	ENOG4105CFG	Acts as a chaperone (By similarity)
E6A57_RS06520	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E6A57_RS06525	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
E6A57_RS06530	ENOG4105DTN	riboflavin biosynthesis protein ribF
E6A57_RS06535	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E6A57_RS06540	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E6A57_RS06545	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E6A57_RS06555	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
E6A57_RS06560	ENOG4105CHV	Transcription elongation factor NusA
E6A57_RS06565	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E6A57_RS06575	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E6A57_RS06580	ENOG4105DZP	Membrane-associated zinc metalloprotease
E6A57_RS06585	ENOG4105KNE	Phosphatidate cytidylyltransferase
E6A57_RS06590	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E6A57_RS06595	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E6A57_RS06600	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E6A57_RS06605	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E6A57_RS06610	ENOG4105CE9	30S ribosomal protein S2
E6A57_RS06615	ENOG4105VC4	domain protein
E6A57_RS06620	ENOG4105F6E	Acyl-transferase
E6A57_RS06625	ENOG4108NUI	synthase
E6A57_RS06630	ENOG4105C9K	Endothelin-converting enzyme 1
E6A57_RS06635	ENOG4105BZ1	(ABC) transporter
E6A57_RS06640	ENOG4105BZ1	(ABC) transporter
E6A57_RS06645	ENOG4105VXM	UPF0154 protein
E6A57_RS06655	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E6A57_RS06675	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E6A57_RS06680	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E6A57_RS06685	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E6A57_RS06690	ENOG4105K5M	30s ribosomal protein S16
E6A57_RS06695	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E6A57_RS06705	ENOG4105CUB	amino acid
E6A57_RS06715	ENOG4105C19	ABC transporter
E6A57_RS06725	ENOG4105DZW	Dipeptidase
E6A57_RS06730	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E6A57_RS06735	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E6A57_RS06740	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E6A57_RS06765	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E6A57_RS06770	ENOG4108JQ7	(ABC) transporter
E6A57_RS06780	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E6A57_RS06785	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E6A57_RS06790	ENOG4105CB5	ATP-dependent DNA helicase recG
E6A57_RS06795	ENOG4105DP4	dak2 domain fusion protein ylov
E6A57_RS06805	ENOG4105VB9	50S ribosomal protein l28
E6A57_RS06835	ENOG4105D5G	Transposase
E6A57_RS06855	ENOG4105DJV	ribulose-phosphate 3-epimerase
E6A57_RS06860	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
E6A57_RS06865	ENOG4105D9P	serine threonine protein kinase
E6A57_RS06875	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E6A57_RS06880	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E6A57_RS06885	ENOG4105C25	Primosomal protein n'
E6A57_RS06890	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E6A57_RS06895	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E6A57_RS06905	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E6A57_RS06910	ENOG4105DX0	Hemolysin A
E6A57_RS06920	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E6A57_RS06925	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E6A57_RS06930	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E6A57_RS06940	ENOG4108ZSR	alkaline shock protein
E6A57_RS06945	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E6A57_RS06950	ENOG4105DC7	peptidase M24
E6A57_RS06955	ENOG4105K46	50S ribosomal protein l27
E6A57_RS06960	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E6A57_RS06985	ENOG41069HH	4-oxalocrotonate tautomerase
E6A57_RS07015	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
E6A57_RS07020	ENOG4105BZ1	(ABC) transporter
E6A57_RS07025	ENOG4105BZ1	(ABC) transporter
E6A57_RS07030	ENOG4108HCJ	Hydrolase
E6A57_RS07050	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
E6A57_RS07065	ENOG4105E0X	reductase
E6A57_RS07075	ENOG4105CSC	Glucose uptake protein
E6A57_RS07090	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E6A57_RS07095	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E6A57_RS07100	ENOG4105CD3	dihydroorotase
E6A57_RS07105	ENOG4105CXT	aspartate transcarbamylase
E6A57_RS07110	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
E6A57_RS07115	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
E6A57_RS07120	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E6A57_RS07125	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E6A57_RS07150	ENOG4105EJQ	L-serine dehydratase
E6A57_RS07155	ENOG4105VG1	fes assembly suf system protein
E6A57_RS07170	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E6A57_RS07175	ENOG4107SC7	Inner membrane transporter yjeM
E6A57_RS07215	ENOG4105US7	Histidine kinase
E6A57_RS07220	ENOG4105ETX	regulatoR
E6A57_RS07230	ENOG4107RK0	Sucrose phosphorylase
E6A57_RS07235	ENOG4105DME	alpha-galactosidase
E6A57_RS07240	ENOG4107RBJ	symporter
E6A57_RS07245	ENOG4108R6W	Transcriptional regulator, ARAC family
E6A57_RS07255	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E6A57_RS07260	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
E6A57_RS07265	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E6A57_RS07275	ENOG4105C4C	beta-galactosidase
E6A57_RS07280	ENOG4107RBJ	symporter
E6A57_RS07285	ENOG4105CQ4	Transcriptional regulator
E6A57_RS07290	ENOG4105CNT	hydrolase family 2
E6A57_RS07295	ENOG4105IKJ	beta-galactosidase small subunit
E6A57_RS07300	ENOG4105CMR	udp-glucose 4-epimerase
E6A57_RS07305	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E6A57_RS07310	ENOG4105VDH	Dihydroxyacetone kinase
E6A57_RS07315	ENOG4108UTZ	Dihydroxyacetone kinase
E6A57_RS07320	ENOG4105CMT	Dihydroxyacetone kinase
E6A57_RS07330	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E6A57_RS07345	ENOG4105D5G	Transposase
E6A57_RS07360	ENOG4105D5G	Transposase
E6A57_RS07405	ENOG4105C5F	glutamine synthetase
E6A57_RS07415	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E6A57_RS07420	ENOG4105WZW	rhodanese family
E6A57_RS07435	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E6A57_RS07440	ENOG4105WDJ	50S ribosomal protein L33
E6A57_RS07445	ENOG4107RF6	penicillin-binding protein
E6A57_RS07455	ENOG4105RD7	BadF BadG BcrA BcrD
E6A57_RS07470	ENOG4105K70	DNA-binding protein
E6A57_RS07475	ENOG4108IPW	abc transporter atp-binding protein
E6A57_RS07500	ENOG410667J	hydrolase
E6A57_RS07510	ENOG4105D01	(LipO)protein
E6A57_RS07525	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E6A57_RS07530	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E6A57_RS07535	ENOG4108HW3	(ABC) transporter
E6A57_RS07540	ENOG4105CDA	abc transporter atp-binding protein
E6A57_RS07545	ENOG4105DRP	amino acid AbC transporter
E6A57_RS07550	ENOG4105E5Q	amino acid AbC transporter
E6A57_RS07560	ENOG4108RWN	rrna methyltransferase
E6A57_RS07565	ENOG410855V	Acylphosphatase
E6A57_RS07570	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
E6A57_RS07595	ENOG4105GR3	Histidine kinase
E6A57_RS07600	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E6A57_RS07610	ENOG4105CDE	UPF0348 protein
E6A57_RS07615	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
E6A57_RS07620	ENOG4108WF2	Metal Dependent Phosphohydrolase
E6A57_RS07625	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E6A57_RS07630	ENOG4105CQW	ribosome biogenesis GTPase YqeH
E6A57_RS07635	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
E6A57_RS07640	ENOG4105D7V	transposase
E6A57_RS07645	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E6A57_RS07650	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E6A57_RS07655	ENOG4105VJV	50s ribosomal protein L35
E6A57_RS07660	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E6A57_RS07675	ENOG4105CJ1	ABC, transporter
E6A57_RS07690	ENOG4105KVH	Transcriptional regulator
E6A57_RS07710	ENOG4105C22	threonyL-tRNA synthetase
E6A57_RS07725	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E6A57_RS07730	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E6A57_RS07735	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E6A57_RS07740	ENOG4105C2M	dna polymerase I
E6A57_RS07750	ENOG410682P	Hypothetical protein (DUF2513)
E6A57_RS07755	ENOG4107QTH	restriction modification system DNA specificity domain
E6A57_RS07830	ENOG4107QI1	Mate efflux family protein
E6A57_RS07835	ENOG4105DFU	Cell wall formation (By similarity)
E6A57_RS07840	ENOG4108VDD	TRNA binding domain protein
E6A57_RS07855	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E6A57_RS07870	ENOG4105K59	histidine triad (HIT) protein
E6A57_RS07880	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
E6A57_RS07890	ENOG4105D7V	transposase
E6A57_RS07915	ENOG4105EQI	Metal Dependent Phosphohydrolase
E6A57_RS07930	ENOG4105WZB	UPF0342 protein
E6A57_RS07935	ENOG4105BZ4	penicillin-binding protein
E6A57_RS07940	ENOG4108YBP	pseudouridine synthase
E6A57_RS07950	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E6A57_RS07955	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E6A57_RS07965	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
E6A57_RS07985	ENOG4105D5G	Transposase
E6A57_RS08005	ENOG4108RJ7	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity)
E6A57_RS08015	ENOG4105C75	arginyL-tRNA synthetase
E6A57_RS08020	ENOG4105S7A	ErfK ybiS ycfS ynhG family protein
E6A57_RS08025	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E6A57_RS08040	ENOG41067S9	phage shock protein C, PspC
E6A57_RS08050	ENOG4105C8T	Leucyl-tRNA synthetase
E6A57_RS08055	ENOG410841Q	phosphoesterase PA-phosphatase related protein
E6A57_RS08060	ENOG4107RSM	transcriptional regulator
E6A57_RS08085	ENOG4105EAH	synthase
E6A57_RS08090	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E6A57_RS08095	ENOG4108JJ8	(ABC) transporter
E6A57_RS08100	ENOG4108JJ9	ABC, transporter
E6A57_RS08105	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E6A57_RS08110	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E6A57_RS08115	ENOG4105HX0	Transcriptional regulator
E6A57_RS08125	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E6A57_RS08130	ENOG4105C5Y	PTS System
E6A57_RS08135	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E6A57_RS08140	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E6A57_RS08210	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E6A57_RS08215	ENOG4105D9U	N-acetyltransferase
E6A57_RS08240	ENOG4105C26	Dehydrogenase
E6A57_RS08250	ENOG4105EYF	MMPL domain protein
E6A57_RS08285	ENOG4107Z33	ABC transporter, permease
E6A57_RS08295	ENOG4105DZW	Dipeptidase
E6A57_RS08300	ENOG4105ZT7	DNA-entry nuclease
E6A57_RS08305	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E6A57_RS08340	ENOG4105BZ1	(ABC) transporter
E6A57_RS08345	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
E6A57_RS08350	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E6A57_RS08355	ENOG4105GR3	Histidine kinase
E6A57_RS08375	ENOG4108U05	Transcriptional regulator
E6A57_RS08380	ENOG4105BZ1	(ABC) transporter
E6A57_RS08385	ENOG4108J59	Extracellular solute-binding protein, family 5
E6A57_RS08400	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E6A57_RS08405	ENOG4105CS9	pantothenic acid kinase
E6A57_RS08415	ENOG4107YB6	acetyltransferase, (GNAT) family
E6A57_RS08420	ENOG4105E89	ABC transporter
E6A57_RS08425	ENOG4105CDA	abc transporter atp-binding protein
E6A57_RS08430	ENOG4105E5Q	amino acid AbC transporter
E6A57_RS08435	ENOG4105EEM	helicase
E6A57_RS08445	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E6A57_RS08465	ENOG4108XCU	pts system
E6A57_RS08475	ENOG4105HDK	L-asparaginase
E6A57_RS08525	ENOG4107QHE	Choloylglycine hydrolase
E6A57_RS08555	ENOG4105D5G	Transposase
E6A57_RS08600	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E6A57_RS08605	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E6A57_RS08615	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
E6A57_RS08620	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
E6A57_RS08630	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E6A57_RS08635	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E6A57_RS08715	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
E6A57_RS08745	ENOG4105D3Q	Sugar transferase
E6A57_RS08750	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
E6A57_RS08755	ENOG4107YJ4	chain length determinant protein
E6A57_RS08765	ENOG4108KGH	TRANSCRIPTIONal
E6A57_RS08775	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E6A57_RS08790	ENOG4105K4H	Nlp p60 protein
E6A57_RS08795	ENOG4107TT5	NLP P60 protein
E6A57_RS08800	ENOG4105K4H	Nlp p60 protein
E6A57_RS08805	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E6A57_RS08825	ENOG4105D7V	transposase
E6A57_RS08830	ENOG4105MTF	NrdI protein
E6A57_RS08835	ENOG4107R25	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E6A57_RS08865	ENOG4105C5H	ABC transporter
E6A57_RS08885	ENOG4108UQV	Membrane
E6A57_RS08890	ENOG4108KGH	TRANSCRIPTIONal
E6A57_RS08895	ENOG4105DPN	Oligoendopeptidase f
E6A57_RS08930	ENOG4105FDK	ABC transporter
E6A57_RS08940	ENOG41082YX	Transcriptional regulator, arsr family
E6A57_RS08945	ENOG4105DM4	PTS System
E6A57_RS08950	ENOG4105DE4	1-phosphofructokinase
E6A57_RS08955	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
E6A57_RS08960	ENOG4105RHA	ABC transporter, permease
E6A57_RS08965	ENOG4108IUX	(ABC) transporter
E6A57_RS08985	ENOG4105VMP	Transcriptional regulator
E6A57_RS09035	ENOG4108WCX	response regulator
E6A57_RS09075	ENOG4105CQB	FAD linked oxidase domain protein
E6A57_RS09100	ENOG4105CG9	aspartate racemase
E6A57_RS09105	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E6A57_RS09130	ENOG4105BZ1	(ABC) transporter
E6A57_RS09135	ENOG4105BZ1	(ABC) transporter
E6A57_RS09145	ENOG4105C3G	gtp-binding protein
E6A57_RS09150	ENOG4105VDK	protein, conserved in bacteria
E6A57_RS09155	ENOG4105FA0	parb-like partition protein
E6A57_RS09160	ENOG4107QJE	Chromosome Partitioning Protein
E6A57_RS09165	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
E6A57_RS09170	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E6A57_RS09195	ENOG4108YYH	Nadph-dependent fmn reductase
E6A57_RS09200	ENOG4107U8T	Nadph-dependent fmn reductase
E6A57_RS09215	ENOG4105DZW	Dipeptidase
E6A57_RS09220	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E6A57_RS09235	ENOG4107TB6	phosphoglycerate mutase
E6A57_RS09245	ENOG4105D1Q	UPF0246 protein
E6A57_RS09270	ENOG4105D7V	transposase
E6A57_RS09290	ENOG4105DUX	Transporter
E6A57_RS09295	ENOG4105CD8	aminopeptidase N
E6A57_RS09325	ENOG4108UVJ	appr-1-p processing domain protein
E6A57_RS09350	ENOG4105EG2	ABC transporter, permease
E6A57_RS09355	ENOG4105D56	permease protein
E6A57_RS09365	ENOG4108IJ9	(ABC) transporter
E6A57_RS09370	ENOG4107URF	beta-phospho-glucomutase
E6A57_RS09380	ENOG4108IUK	alpha amylase, catalytic
E6A57_RS09385	ENOG4105CG3	alpha amylase, catalytic region
E6A57_RS09395	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E6A57_RS09400	ENOG4105FKQ	transcriptional regulator
E6A57_RS09410	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
E6A57_RS09415	ENOG4105DWF	phosphomethylpyrimidine kinase
E6A57_RS09430	ENOG4105D7V	transposase
E6A57_RS09440	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
E6A57_RS09455	ENOG4105FDK	ABC transporter
E6A57_RS09470	ENOG4105F1K	Glutamine amidotransferase
E6A57_RS09475	ENOG4107TT5	NLP P60 protein
E6A57_RS09495	ENOG4108UZ3	Transporter
E6A57_RS09505	ENOG4108UZ3	Transporter
E6A57_RS09525	ENOG4105C5H	ABC transporter
E6A57_RS09545	ENOG4105C83	adenylosuccinate lyase
E6A57_RS09550	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E6A57_RS09555	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
E6A57_RS09575	ENOG4105CU9	asparagine synthetase A
E6A57_RS09585	ENOG4108Z86	Glutamine amidotransferase
E6A57_RS09595	ENOG4105C85	amino acid
E6A57_RS09610	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E6A57_RS09660	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
E6A57_RS09665	ENOG4105X96	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
E6A57_RS09670	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
E6A57_RS09675	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
E6A57_RS09695	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E6A57_RS09700	ENOG4105C59	p-type ATPase
E6A57_RS09715	ENOG4105BZ1	(ABC) transporter
E6A57_RS09740	ENOG4105WT3	Transcriptional regulator
E6A57_RS09755	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E6A57_RS09760	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
E6A57_RS09770	ENOG4105DIH	basic membrane
E6A57_RS09775	ENOG4105DIH	basic membrane
E6A57_RS09780	ENOG4108JQ9	ABC transporter
E6A57_RS09785	ENOG4105UIB	(ABC) transporter
E6A57_RS09795	ENOG4105CV8	reductase
E6A57_RS09800	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E6A57_RS09805	ENOG4105ZMH	deoxynucleoside kinase
E6A57_RS09810	ENOG4105ZMH	deoxynucleoside kinase
E6A57_RS09820	ENOG410667J	hydrolase
E6A57_RS09825	ENOG4105C7N	Xanthine uracil vitamin C permease
E6A57_RS09845	ENOG4108Z6Z	Transcriptional regulator
E6A57_RS09850	ENOG4105C7N	Xanthine uracil vitamin C permease
E6A57_RS09880	ENOG4105E4P	ATPase (AAA
E6A57_RS09890	ENOG4105C7N	Xanthine uracil vitamin C permease
E6A57_RS09930	ENOG4106JUT	Streptomycin 3''-adenylyltransferase
E6A57_RS09935	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
E6A57_RS09955	ENOG4105NA0	Transcriptional regulator
E6A57_RS09975	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E6A57_RS10000	ENOG4105F3R	pts system mannose fructose sorbose family iid
E6A57_RS10010	ENOG4105C54	Major Facilitator superfamily
E6A57_RS10045	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
E6A57_RS10055	ENOG4105C7K	acetolactate synthase
E6A57_RS10060	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E6A57_RS10065	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E6A57_RS10070	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E6A57_RS10075	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E6A57_RS10080	ENOG4105VG0	50S ribosomal protein l34