locus-tag	class	description
PRL2021_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PRL2021_RS00010	COG0592	DNA-directed DNA polymerase activity
PRL2021_RS00015	COG3344	reverse transcriptase
PRL2021_RS00020	COG2501	S4 domain
PRL2021_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PRL2021_RS00030	COG0187	DNA topoisomerase II activity
PRL2021_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PRL2021_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
PRL2021_RS00045	COG0629	single-stranded DNA binding
PRL2021_RS00050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PRL2021_RS00060	COG0359	binds to the 23S rRNA
PRL2021_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
PRL2021_RS00075	COG1307	EDD domain protein, DegV family
PRL2021_RS00080	COG1132	(ABC) transporter
PRL2021_RS00090	COG1940	carbohydrate kinase activity
PRL2021_RS00100	COG2261	transglycosylase associated protein
PRL2021_RS00110	COG1285	pathogenesis
PRL2021_RS00200	COG0531	amino acid
PRL2021_RS00250	COG0628	permease
PRL2021_RS00270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PRL2021_RS00290	COG1011	Hydrolase
PRL2021_RS00295	COG0598	Magnesium transport protein CorA
PRL2021_RS00300	COG0656	L-ascorbic acid biosynthetic process
PRL2021_RS00310	COG0561	phosphatase activity
PRL2021_RS00320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRL2021_RS00335	COG0708	Exodeoxyribonuclease III
PRL2021_RS00340	COG0531	amino acid
PRL2021_RS00435	COG1442	glycosyl transferase family 8
PRL2021_RS00455	COG1442	glycosyl transferase family 8
PRL2021_RS00480	COG0745	RESPONSE REGULATOR receiver
PRL2021_RS00490	COG5002	protein histidine kinase activity
PRL2021_RS00520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PRL2021_RS00525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PRL2021_RS00545	COG2267	carboxylic ester hydrolase activity
PRL2021_RS00555	COG1122	ATPase activity
PRL2021_RS00565	COG0501	Belongs to the peptidase M48B family
PRL2021_RS00570	COG1704	LemA family
PRL2021_RS00600	COG1215	transferase activity, transferring glycosyl groups
PRL2021_RS00630	COG1126	abc transporter atp-binding protein
PRL2021_RS00635	COG0765	amino acid transport
PRL2021_RS00640	COG2094	Belongs to the DNA glycosylase MPG family
PRL2021_RS00645	COG3189	MarR family transcriptional regulator
PRL2021_RS00650	COG0861	Integral membrane protein TerC family
PRL2021_RS00660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PRL2021_RS00670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PRL2021_RS00680	COG0328	RNA-DNA hybrid ribonuclease activity
PRL2021_RS00695	COG1216	Glycosyl transferase, family 2
PRL2021_RS00745	COG0765	amino acid transport
PRL2021_RS00750	COG1126	abc transporter atp-binding protein
PRL2021_RS00760	COG1181	Belongs to the D-alanine--D-alanine ligase family
PRL2021_RS00815	COG2365	Tyrosine phosphatase family
PRL2021_RS00820	COG0589	response to stress
PRL2021_RS00830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PRL2021_RS00845	COG0519	Catalyzes the synthesis of GMP from XMP
PRL2021_RS00860	COG0367	asparagine synthase
PRL2021_RS00875	COG0602	queuosine metabolic process
PRL2021_RS00880	COG2151	metal-sulfur cluster biosynthetic enzyme
PRL2021_RS00890	COG2814	Major facilitator Superfamily
PRL2021_RS00895	COG3590	peptidase
PRL2021_RS00900	COG3158	transport of potassium into the cell
PRL2021_RS01005	COG1705	Flagellar rod assembly protein muramidase FlgJ
PRL2021_RS01005	COG1388	LysM domain
PRL2021_RS01040	COG0588	phosphoglycerate mutase activity
PRL2021_RS01050	COG1316	TRANSCRIPTIONal
PRL2021_RS01055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PRL2021_RS01060	COG1368	sulfuric ester hydrolase activity
PRL2021_RS01075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PRL2021_RS01090	COG3579	cysteine-type endopeptidase activity
PRL2021_RS01095	COG1418	mRNA catabolic process
PRL2021_RS01100	COG4166	transmembrane transport
PRL2021_RS01105	COG4166	transmembrane transport
PRL2021_RS01115	COG0517	IMP dehydrogenase activity
PRL2021_RS01115	COG0516	GMP reductase activity
PRL2021_RS01120	COG0601	transmembrane transport
PRL2021_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PRL2021_RS01130	COG0444	Belongs to the ABC transporter superfamily
PRL2021_RS01135	COG4608	Belongs to the ABC transporter superfamily
PRL2021_RS01140	COG3579	cysteine-type endopeptidase activity
PRL2021_RS01180	COG2131	deaminase
PRL2021_RS01195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PRL2021_RS01195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PRL2021_RS01200	COG0084	hydrolase, TatD family'
PRL2021_RS01210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PRL2021_RS01215	COG4466	Protein conserved in bacteria
PRL2021_RS01220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PRL2021_RS01225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PRL2021_RS01245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PRL2021_RS01260	COG1078	dGTPase activity
PRL2021_RS01270	COG3343	RNA polymerase activity
PRL2021_RS01275	COG0504	CTP synthase activity
PRL2021_RS01280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PRL2021_RS01295	COG4690	dipeptidase activity
PRL2021_RS01305	COG2233	PERMEase
PRL2021_RS01310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PRL2021_RS01315	COG1396	sequence-specific DNA binding
PRL2021_RS01320	COG0519	Catalyzes the synthesis of GMP from XMP
PRL2021_RS01345	COG1575	Belongs to the MenA family. Type 1 subfamily
PRL2021_RS01365	COG1304	FMN binding
PRL2021_RS01380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PRL2021_RS01385	COG0531	amino acid
PRL2021_RS01390	COG0561	phosphatase activity
PRL2021_RS01395	COG0366	Alpha amylase catalytic
PRL2021_RS01400	COG0254	rRNA binding
PRL2021_RS01405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PRL2021_RS01415	COG0736	holo-[acyl-carrier-protein] synthase activity
PRL2021_RS01420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PRL2021_RS01430	COG0039	L-malate dehydrogenase activity
PRL2021_RS01435	COG0193	aminoacyl-tRNA hydrolase activity
PRL2021_RS01440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PRL2021_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PRL2021_RS01460	COG0037	tRNA processing
PRL2021_RS01470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PRL2021_RS01475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PRL2021_RS01480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PRL2021_RS01485	COG2801	Transposase and inactivated derivatives
PRL2021_RS01520	COG1956	GAF domain-containing protein
PRL2021_RS01525	COG0542	response to heat
PRL2021_RS01530	COG0085	RNA polymerase activity
PRL2021_RS01535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PRL2021_RS01540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PRL2021_RS01545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PRL2021_RS01550	COG0049	tRNA binding
PRL2021_RS01555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PRL2021_RS01560	COG0051	transcription antitermination factor activity, RNA binding
PRL2021_RS01565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PRL2021_RS01570	COG0088	Forms part of the polypeptide exit tunnel
PRL2021_RS01575	COG0089	rRNA binding
PRL2021_RS01580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PRL2021_RS01590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PRL2021_RS01595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PRL2021_RS01600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PRL2021_RS01605	COG0255	Belongs to the universal ribosomal protein uL29 family
PRL2021_RS01610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PRL2021_RS01615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PRL2021_RS01620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PRL2021_RS01625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PRL2021_RS01635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PRL2021_RS01640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PRL2021_RS01645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PRL2021_RS01650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PRL2021_RS01655	COG1841	ribosomal large subunit assembly
PRL2021_RS01660	COG0200	Binds to the 23S rRNA
PRL2021_RS01670	COG0563	adenylate kinase activity
PRL2021_RS01675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PRL2021_RS01685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PRL2021_RS01690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PRL2021_RS01695	COG0202	RNA polymerase activity
PRL2021_RS01700	COG0203	ribosomal protein L17
PRL2021_RS01705	COG1122	ATPase activity
PRL2021_RS01710	COG1122	ATPase activity
PRL2021_RS01715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PRL2021_RS01720	COG0101	tRNA pseudouridine synthase activity
PRL2021_RS01725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PRL2021_RS01730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PRL2021_RS01735	COG0582	viral genome integration into host DNA
PRL2021_RS01760	COG1349	DNA-binding transcription factor activity
PRL2021_RS01775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PRL2021_RS01795	COG3623	hexulose-6-phosphate isomerase
PRL2021_RS01800	COG0235	Class ii aldolase
PRL2021_RS01805	COG0546	phosphoglycolate phosphatase activity
PRL2021_RS01810	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PRL2021_RS01880	COG1230	cation diffusion facilitator family transporter
PRL2021_RS01890	COG0588	phosphoglycerate mutase activity
PRL2021_RS01920	COG0756	dUTP diphosphatase activity
PRL2021_RS01930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PRL2021_RS01935	COG0215	cysteine-tRNA ligase activity
PRL2021_RS01940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PRL2021_RS01945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PRL2021_RS01975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PRL2021_RS01985	COG0250	Participates in transcription elongation, termination and antitermination
PRL2021_RS01990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PRL2021_RS01995	COG0081	regulation of translation
PRL2021_RS02005	COG0573	inorganic phosphate transmembrane transporter activity
PRL2021_RS02010	COG0581	inorganic phosphate transmembrane transporter activity
PRL2021_RS02015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PRL2021_RS02020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PRL2021_RS02045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PRL2021_RS02050	COG0222	ribosome binding
PRL2021_RS02060	COG2813	Specifically methylates the guanine in position
PRL2021_RS02090	COG0590	tRNA wobble adenosine to inosine editing
PRL2021_RS02100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PRL2021_RS02125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PRL2021_RS02130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PRL2021_RS02140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PRL2021_RS02145	COG3870	Protein conserved in bacteria
PRL2021_RS02170	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PRL2021_RS02180	COG1214	PFAM Peptidase M22, glycoprotease
PRL2021_RS02190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PRL2021_RS02195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PRL2021_RS02210	COG0488	(ABC) transporter
PRL2021_RS02215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PRL2021_RS02235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS02235	COG1263	PTS System
PRL2021_RS02235	COG2190	(PTS) system
PRL2021_RS02250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PRL2021_RS02255	COG0459	protein refolding
PRL2021_RS02260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PRL2021_RS02265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PRL2021_RS02270	COG0632	four-way junction helicase activity
PRL2021_RS02275	COG2255	four-way junction helicase activity
PRL2021_RS02285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PRL2021_RS02290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PRL2021_RS02295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PRL2021_RS02300	COG0513	Belongs to the DEAD box helicase family
PRL2021_RS02305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PRL2021_RS02310	COG4472	Bacterial protein of unknown function (DUF965)
PRL2021_RS02315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PRL2021_RS02320	COG3906	Belongs to the UPF0473 family
PRL2021_RS02325	COG1193	negative regulation of DNA recombination
PRL2021_RS02330	COG3118	belongs to the thioredoxin family
PRL2021_RS02345	COG1719	4-vinyl reductase, 4VR
PRL2021_RS02350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PRL2021_RS02355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PRL2021_RS02400	COG1131	(ABC) transporter
PRL2021_RS02405	COG0668	transmembrane transport
PRL2021_RS02420	COG2801	Transposase and inactivated derivatives
PRL2021_RS02430	COG0006	proline dipeptidase activity
PRL2021_RS02440	COG0584	glycerophosphoryl diester phosphodiesterase
PRL2021_RS02450	COG0737	Belongs to the 5'-nucleotidase family
PRL2021_RS02460	COG0647	UMP catabolic process
PRL2021_RS02470	COG0586	Pfam SNARE associated Golgi protein
PRL2021_RS02475	COG0492	ferredoxin-NADP+ reductase activity
PRL2021_RS02635	COG0438	transferase activity, transferring glycosyl groups
PRL2021_RS02640	COG0438	transferase activity, transferring glycosyl groups
PRL2021_RS02650	COG1368	sulfuric ester hydrolase activity
PRL2021_RS02655	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PRL2021_RS02660	COG0557	exoribonuclease II activity
PRL2021_RS02665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PRL2021_RS02720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PRL2021_RS02725	COG0477	Major facilitator Superfamily
PRL2021_RS02730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS02730	COG1263	PTS System
PRL2021_RS02740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PRL2021_RS02750	COG1737	Transcriptional regulator
PRL2021_RS02765	COG1271	oxidase subunit
PRL2021_RS02770	COG1294	oxidase, subunit
PRL2021_RS02775	COG4988	ABC transporter
PRL2021_RS02780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PRL2021_RS02785	COG2226	methyltransferase
PRL2021_RS02790	COG0142	geranyltranstransferase activity
PRL2021_RS02805	COG1053	succinate dehydrogenase
PRL2021_RS02805	COG3976	FMN-binding domain protein
PRL2021_RS02820	COG0583	DNA-binding transcription factor activity
PRL2021_RS02825	COG0671	phosphoesterase, PA-phosphatase related
PRL2021_RS02830	COG0495	leucyl-tRNA aminoacylation
PRL2021_RS02840	COG2244	polysaccharide biosynthetic process
PRL2021_RS02845	COG1983	PspC domain protein
PRL2021_RS02855	COG1686	Belongs to the peptidase S11 family
PRL2021_RS02860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PRL2021_RS02865	COG1376	ErfK ybiS ycfS ynhG family protein
PRL2021_RS02870	COG0018	arginyl-trna synthetase
PRL2021_RS02875	COG0191	fructose-bisphosphate aldolase activity
PRL2021_RS02945	COG0675	Transposase, IS605 OrfB family
PRL2021_RS02980	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PRL2021_RS02985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PRL2021_RS02990	COG0588	phosphoglycerate mutase activity
PRL2021_RS02995	COG0574	Belongs to the PEP-utilizing enzyme family
PRL2021_RS02995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PRL2021_RS03000	COG0564	pseudouridine synthase activity
PRL2021_RS03005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PRL2021_RS03010	COG3679	Belongs to the UPF0342 family
PRL2021_RS03025	COG3481	metal-dependent phosphohydrolase, HD sub domain
PRL2021_RS03055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRL2021_RS03065	COG0537	adenosine 5'-monophosphoramidase activity
PRL2021_RS03070	COG1131	(ABC) transporter
PRL2021_RS03080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PRL2021_RS03095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PRL2021_RS03100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PRL2021_RS03110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PRL2021_RS03170	COG0151	Belongs to the GarS family
PRL2021_RS03175	COG3344	reverse transcriptase
PRL2021_RS03180	COG2207	Transcriptional regulator
PRL2021_RS03215	COG4372	Transposase
PRL2021_RS03235	COG3842	ATPase activity
PRL2021_RS03245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PRL2021_RS03245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PRL2021_RS03250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PRL2021_RS03255	COG0237	dephospho-CoA kinase activity
PRL2021_RS03260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PRL2021_RS03270	COG1484	DNA-dependent DNA replication
PRL2021_RS03275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PRL2021_RS03325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PRL2021_RS03335	COG3842	ATPase activity
PRL2021_RS03340	COG0395	ABC-type sugar transport system, permease component
PRL2021_RS03350	COG1176	ABC-type spermidine putrescine transport system, permease component I
PRL2021_RS03360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PRL2021_RS03365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PRL2021_RS03370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PRL2021_RS03375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PRL2021_RS03385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PRL2021_RS03390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PRL2021_RS03395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PRL2021_RS03400	COG1713	HD superfamily hydrolase involved in NAD metabolism
PRL2021_RS03405	COG0799	negative regulation of ribosome biogenesis
PRL2021_RS03410	COG1323	Belongs to the UPF0348 family
PRL2021_RS03420	COG0745	RESPONSE REGULATOR receiver
PRL2021_RS03425	COG5002	protein histidine kinase activity
PRL2021_RS03465	COG0706	membrane insertase activity
PRL2021_RS03470	COG1254	Belongs to the acylphosphatase family
PRL2021_RS03480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PRL2021_RS03485	COG1733	regulation of RNA biosynthetic process
PRL2021_RS03490	COG0765	amino acid transport
PRL2021_RS03495	COG0765	amino acid transport
PRL2021_RS03500	COG1126	abc transporter atp-binding protein
PRL2021_RS03505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRL2021_RS03510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PRL2021_RS03515	COG0072	phenylalanine-tRNA ligase activity
PRL2021_RS03520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PRL2021_RS03545	COG0561	phosphatase activity
PRL2021_RS03550	COG4166	transmembrane transport
PRL2021_RS03610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PRL2021_RS03615	COG4604	ABC transporter, ATP-binding protein
PRL2021_RS03650	COG2971	BadF BadG BcrA BcrD
PRL2021_RS03660	COG0768	penicillin binding
PRL2021_RS03665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PRL2021_RS03670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PRL2021_RS03685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PRL2021_RS03690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PRL2021_RS03745	COG4166	transmembrane transport
PRL2021_RS03750	COG1737	Transcriptional regulator
PRL2021_RS03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PRL2021_RS03780	COG3458	cephalosporin-C deacetylase activity
PRL2021_RS03815	COG0583	DNA-binding transcription factor activity
PRL2021_RS03820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PRL2021_RS03830	COG1072	(Pantothenic acid kinase))
PRL2021_RS03835	COG3344	reverse transcriptase
PRL2021_RS03885	COG2801	Transposase and inactivated derivatives
PRL2021_RS03925	COG2801	Transposase and inactivated derivatives
PRL2021_RS03930	COG1609	Transcriptional regulator
PRL2021_RS03945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PRL2021_RS03970	COG3250	beta-galactosidase activity
PRL2021_RS03975	COG1609	Transcriptional regulator
PRL2021_RS04000	COG1874	Beta-galactosidase
PRL2021_RS04005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PRL2021_RS04010	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PRL2021_RS04025	COG2017	converts alpha-aldose to the beta-anomer
PRL2021_RS04040	COG1653	transport
PRL2021_RS04045	COG1175	transmembrane transport
PRL2021_RS04050	COG0395	ABC-type sugar transport system, permease component
PRL2021_RS04055	COG3842	ATPase activity
PRL2021_RS04060	COG3345	alpha-galactosidase
PRL2021_RS04065	COG0366	Alpha amylase catalytic
PRL2021_RS04070	COG2357	RelA SpoT domain protein
PRL2021_RS04080	COG5002	protein histidine kinase activity
PRL2021_RS04130	COG1304	FMN binding
PRL2021_RS04140	COG2151	metal-sulfur cluster biosynthetic enzyme
PRL2021_RS04145	COG1760	l-serine dehydratase
PRL2021_RS04150	COG1760	l-serine dehydratase
PRL2021_RS04170	COG0488	(ABC) transporter
PRL2021_RS04180	COG1523	belongs to the glycosyl hydrolase 13 family
PRL2021_RS04240	COG1802	Transcriptional regulator
PRL2021_RS04255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PRL2021_RS04260	COG0284	orotidine-5'-phosphate decarboxylase activity
PRL2021_RS04265	COG0167	dihydroorotate dehydrogenase activity
PRL2021_RS04275	COG0540	Belongs to the ATCase OTCase family
PRL2021_RS04280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PRL2021_RS04285	COG0505	Belongs to the CarA family
PRL2021_RS04290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PRL2021_RS04305	COG4975	Glucose uptake
PRL2021_RS04320	COG2936	dipeptidyl-peptidase activity
PRL2021_RS04355	COG1132	(ABC) transporter
PRL2021_RS04360	COG1132	(ABC) transporter
PRL2021_RS04365	COG1393	Belongs to the ArsC family
PRL2021_RS04395	COG1942	4-Oxalocrotonate Tautomerase
PRL2021_RS04430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PRL2021_RS04435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PRL2021_RS04440	COG0006	proline dipeptidase activity
PRL2021_RS04445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PRL2021_RS04450	COG1302	Protein conserved in bacteria
PRL2021_RS04460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PRL2021_RS04465	COG1570	exodeoxyribonuclease VII activity
PRL2021_RS04470	COG1722	exodeoxyribonuclease VII activity
PRL2021_RS04480	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PRL2021_RS04485	COG0497	DNA recombination
PRL2021_RS04495	COG0194	GDP metabolic process
PRL2021_RS04500	COG1758	RNA polymerase activity
PRL2021_RS04505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PRL2021_RS04510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PRL2021_RS04515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PRL2021_RS04515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PRL2021_RS04525	COG0515	serine threonine protein kinase
PRL2021_RS04525	COG2815	serine threonine protein kinase
PRL2021_RS04530	COG1162	GTPase activity
PRL2021_RS04535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PRL2021_RS04550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PRL2021_RS04560	COG1461	Dihydroxyacetone kinase
PRL2021_RS04565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PRL2021_RS04570	COG0416	fatty acid biosynthetic process
PRL2021_RS04575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PRL2021_RS04585	COG4608	Belongs to the ABC transporter superfamily
PRL2021_RS04590	COG0601	transmembrane transport
PRL2021_RS04610	COG0571	ribonuclease III activity
PRL2021_RS04615	COG1196	nuclear chromosome segregation
PRL2021_RS04620	COG0552	protein localization to endoplasmic reticulum
PRL2021_RS04635	COG1136	(ABC) transporter
PRL2021_RS04655	COG2801	Transposase and inactivated derivatives
PRL2021_RS04665	COG0531	amino acid
PRL2021_RS04670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PRL2021_RS04675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PRL2021_RS04680	COG0228	four-way junction DNA binding
PRL2021_RS04685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PRL2021_RS04690	COG0336	Belongs to the RNA methyltransferase TrmD family
PRL2021_RS04695	COG0335	large ribosomal subunit rRNA binding
PRL2021_RS04735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PRL2021_RS04740	COG4224	UPF0291 protein
PRL2021_RS04745	COG3763	UPF0154 protein
PRL2021_RS04750	COG1132	(ABC) transporter
PRL2021_RS04755	COG1132	(ABC) transporter
PRL2021_RS04760	COG3590	peptidase
PRL2021_RS04765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PRL2021_RS04775	COG0204	Acyl-transferase
PRL2021_RS04780	COG2827	Endonuclease containing a URI domain
PRL2021_RS04785	COG0052	Belongs to the universal ribosomal protein uS2 family
PRL2021_RS04790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PRL2021_RS04795	COG0528	UMP kinase activity
PRL2021_RS04800	COG0233	cytoplasmic translational termination
PRL2021_RS04805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PRL2021_RS04810	COG4589	Belongs to the CDS family
PRL2021_RS04815	COG0750	zinc metalloprotease
PRL2021_RS04820	COG0442	prolyl-tRNA aminoacylation
PRL2021_RS04830	COG0779	Required for maturation of 30S ribosomal subunits
PRL2021_RS04835	COG0195	Participates in both transcription termination and antitermination
PRL2021_RS04840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
PRL2021_RS04850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PRL2021_RS04855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PRL2021_RS04860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PRL2021_RS04865	COG0196	riboflavin kinase activity
PRL2021_RS04870	COG1420	regulation of RNA biosynthetic process
PRL2021_RS04875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PRL2021_RS04880	COG0443	Heat shock 70 kDa protein
PRL2021_RS04885	COG0484	heat shock protein binding
PRL2021_RS04895	COG0481	GTPase activity
PRL2021_RS04900	COG0582	viral genome integration into host DNA
PRL2021_RS04995	COG3620	sequence-specific DNA binding
PRL2021_RS05100	COG3728	DNA packaging
PRL2021_RS05100	COG5484	DNA packaging
PRL2021_RS05185	COG1388	LysM domain
PRL2021_RS05185	COG1705	Flagellar rod assembly protein muramidase FlgJ
PRL2021_RS05285	COG2337	Toxic component of a toxin-antitoxin (TA) module
PRL2021_RS05290	COG3764	Sortase (surface protein transpeptidase)
PRL2021_RS05295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PRL2021_RS05295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PRL2021_RS05300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PRL2021_RS05340	COG0583	DNA-binding transcription factor activity
PRL2021_RS05345	COG2235	arginine
PRL2021_RS05350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PRL2021_RS05355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PRL2021_RS05445	COG0527	aspartate kinase activity
PRL2021_RS05460	COG0083	homoserine kinase activity
PRL2021_RS05470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PRL2021_RS05510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PRL2021_RS05765	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
PRL2021_RS05775	COG1518	maintenance of DNA repeat elements
PRL2021_RS05800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PRL2021_RS05805	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PRL2021_RS05815	COG1702	phosphate starvation-inducible protein PhoH
PRL2021_RS05820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PRL2021_RS05825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PRL2021_RS05830	COG1381	Involved in DNA repair and RecF pathway recombination
PRL2021_RS05835	COG0752	glycyl-tRNA synthetase alpha subunit
PRL2021_RS05840	COG0751	glycine-tRNA ligase activity
PRL2021_RS05845	COG0358	DNA primase activity
PRL2021_RS05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PRL2021_RS05860	COG2801	Transposase and inactivated derivatives
PRL2021_RS05875	COG2384	SAM-dependent methyltransferase
PRL2021_RS05880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PRL2021_RS05885	COG2195	Cleaves the N-terminal amino acid of tripeptides
PRL2021_RS05890	COG1725	Transcriptional regulator
PRL2021_RS05895	COG1131	(ABC) transporter
PRL2021_RS05940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PRL2021_RS05940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PRL2021_RS05945	COG0561	phosphatase activity
PRL2021_RS05950	COG1304	FMN binding
PRL2021_RS05970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PRL2021_RS05975	COG1074	ATP-dependent DNA helicase activity
PRL2021_RS05995	COG0017	Asparaginyl-tRNA synthetase
PRL2021_RS06005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PRL2021_RS06010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PRL2021_RS06015	COG3331	DNA recombination
PRL2021_RS06020	COG4474	Belongs to the UPF0398 family
PRL2021_RS06030	COG3599	regulation of cell shape
PRL2021_RS06040	COG0116	Belongs to the methyltransferase superfamily
PRL2021_RS06055	COG3344	reverse transcriptase
PRL2021_RS06060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PRL2021_RS06090	COG1335	isochorismatase
PRL2021_RS06100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PRL2021_RS06105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PRL2021_RS06110	COG0187	DNA topoisomerase II activity
PRL2021_RS06120	COG0583	DNA-binding transcription factor activity
PRL2021_RS06125	COG1227	inorganic diphosphatase activity
PRL2021_RS06210	COG1307	EDD domain protein, DegV family
PRL2021_RS06225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PRL2021_RS06230	COG0505	Belongs to the CarA family
PRL2021_RS06235	COG0564	pseudouridine synthase activity
PRL2021_RS06245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PRL2021_RS06305	COG0732	type I restriction modification DNA specificity domain
PRL2021_RS06325	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PRL2021_RS06355	COG1653	transport
PRL2021_RS06375	COG0366	Alpha amylase catalytic
PRL2021_RS06380	COG2188	Transcriptional regulator
PRL2021_RS06385	COG1263	PTS System
PRL2021_RS06385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS06385	COG2190	(PTS) system
PRL2021_RS06395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PRL2021_RS06400	COG2195	Cleaves the N-terminal amino acid of tripeptides
PRL2021_RS06430	COG0110	maltose O-acetyltransferase activity
PRL2021_RS06445	COG0671	phosphoesterase, PA-phosphatase related
PRL2021_RS06450	COG2040	homocysteine
PRL2021_RS06475	COG0514	ATP-dependent DNA helicase (RecQ)
PRL2021_RS06480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PRL2021_RS06490	COG0531	amino acid
PRL2021_RS06505	COG0833	amino acid
PRL2021_RS06515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PRL2021_RS06540	COG2801	Transposase and inactivated derivatives
PRL2021_RS06550	COG0656	L-ascorbic acid biosynthetic process
PRL2021_RS06560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PRL2021_RS06575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PRL2021_RS06580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PRL2021_RS06585	COG0758	DNA mediated transformation
PRL2021_RS06590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PRL2021_RS06595	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PRL2021_RS06605	COG4479	Belongs to the UPF0346 family
PRL2021_RS06610	COG1307	EDD domain protein, DegV family
PRL2021_RS06615	COG1272	protein, Hemolysin III
PRL2021_RS06620	COG0617	tRNA 3'-terminal CCA addition
PRL2021_RS06625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PRL2021_RS06725	COG1160	GTP binding
PRL2021_RS06730	COG0539	negative regulation of cytoplasmic translation
PRL2021_RS06735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PRL2021_RS06745	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PRL2021_RS06750	COG3344	reverse transcriptase
PRL2021_RS06755	COG1187	pseudouridine synthase activity
PRL2021_RS06760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PRL2021_RS06765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PRL2021_RS06780	COG2996	Protein conserved in bacteria
PRL2021_RS06790	COG0205	6-phosphofructokinase activity
PRL2021_RS06795	COG0587	DNA-directed DNA polymerase activity
PRL2021_RS06805	COG0737	Belongs to the 5'-nucleotidase family
PRL2021_RS06810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PRL2021_RS06820	COG0300	oxidoreductase activity
PRL2021_RS06825	COG1234	tRNA 3'-trailer cleavage
PRL2021_RS06830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PRL2021_RS06830	COG2755	lipolytic protein G-D-S-L family
PRL2021_RS06835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PRL2021_RS06840	COG0322	excinuclease ABC activity
PRL2021_RS06845	COG0586	Pfam SNARE associated Golgi protein
PRL2021_RS06850	COG0531	amino acid
PRL2021_RS06855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRL2021_RS06860	COG0561	phosphatase activity
PRL2021_RS06880	COG0436	Aminotransferase
PRL2021_RS06885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PRL2021_RS06890	COG0124	histidyl-tRNA synthetase
PRL2021_RS06895	COG1490	D-aminoacyl-tRNA deacylase activity
PRL2021_RS06900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PRL2021_RS06905	COG2264	protein methyltransferase activity
PRL2021_RS06910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PRL2021_RS06960	COG4720	Psort location CytoplasmicMembrane, score
PRL2021_RS06965	COG1122	ATPase activity
PRL2021_RS06980	COG2707	UPF0756 membrane protein
PRL2021_RS06995	COG3052	prosthetic group binding
PRL2021_RS07005	COG2267	carboxylic ester hydrolase activity
PRL2021_RS07015	COG0471	metal ion transport
PRL2021_RS07020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PRL2021_RS07025	COG3579	cysteine-type endopeptidase activity
PRL2021_RS07030	COG0039	L-malate dehydrogenase activity
PRL2021_RS07035	COG1053	succinate dehydrogenase
PRL2021_RS07040	COG0114	fumarate hydratase activity
PRL2021_RS07050	COG2011	ABC-type metal ion transport system permease component
PRL2021_RS07055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PRL2021_RS07070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PRL2021_RS07075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PRL2021_RS07080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PRL2021_RS07090	COG1113	amino acid transport
PRL2021_RS07130	COG0477	Major facilitator Superfamily
PRL2021_RS07155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PRL2021_RS07170	COG1114	Component of the transport system for branched-chain amino acids
PRL2021_RS07180	COG0300	oxidoreductase activity
PRL2021_RS07185	COG1063	alcohol dehydrogenase
PRL2021_RS07205	COG1309	transcriptional regulator
PRL2021_RS07210	COG1073	alpha beta
PRL2021_RS07225	COG1914	H( )-stimulated, divalent metal cation uptake system
PRL2021_RS07235	COG0719	Fe-S assembly protein
PRL2021_RS07240	COG0822	iron-sulfur transferase activity
PRL2021_RS07245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PRL2021_RS07250	COG0719	Fe-S assembly protein
PRL2021_RS07265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PRL2021_RS07295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRL2021_RS07295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRL2021_RS07305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PRL2021_RS07305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PRL2021_RS07310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PRL2021_RS07345	COG1215	transferase activity, transferring glycosyl groups
PRL2021_RS07370	COG0783	Belongs to the Dps family
PRL2021_RS07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PRL2021_RS07410	COG2855	membrane
PRL2021_RS07420	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PRL2021_RS07435	COG0148	phosphopyruvate hydratase activity
PRL2021_RS07460	COG2723	6-phospho-beta-galactosidase activity
PRL2021_RS07465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PRL2021_RS07470	COG2188	Transcriptional regulator
PRL2021_RS07475	COG2723	6-phospho-beta-galactosidase activity
PRL2021_RS07485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PRL2021_RS07500	COG1447	Phosphotransferase system cellobiose-specific component IIA
PRL2021_RS07505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PRL2021_RS07510	COG2188	Transcriptional regulator
PRL2021_RS07515	COG2723	6-phospho-beta-galactosidase activity
PRL2021_RS07525	COG1957	nucleoside hydrolase
PRL2021_RS07530	COG1053	succinate dehydrogenase
PRL2021_RS07530	COG0431	NADPH-dependent FMN reductase
PRL2021_RS07530	COG3976	FMN-binding domain protein
PRL2021_RS07540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PRL2021_RS07545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PRL2021_RS07550	COG0436	Aminotransferase
PRL2021_RS07555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PRL2021_RS07560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PRL2021_RS07565	COG1473	amidohydrolase
PRL2021_RS07570	COG2171	N-acyltransferase activity
PRL2021_RS07575	COG0019	diaminopimelate decarboxylase activity
PRL2021_RS07580	COG0527	aspartate kinase activity
PRL2021_RS07585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PRL2021_RS07595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PRL2021_RS07600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PRL2021_RS07605	COG0544	peptidyl-prolyl cis-trans isomerase activity
PRL2021_RS07615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PRL2021_RS07635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PRL2021_RS07640	COG0268	Binds directly to 16S ribosomal RNA
PRL2021_RS07645	COG1466	dna polymerase III delta subunit
PRL2021_RS07650	COG2333	competence protein COMEC
PRL2021_RS07650	COG0658	competence protein
PRL2021_RS07655	COG1555	photosystem II stabilization
PRL2021_RS07660	COG3480	Lon protease (S16) C-terminal proteolytic domain
PRL2021_RS07665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PRL2021_RS07670	COG0742	ribosomal rna small subunit methyltransferase
PRL2021_RS07675	COG4471	UPF0298 protein
PRL2021_RS07680	COG0772	Belongs to the SEDS family
PRL2021_RS07685	COG1217	gtp-binding protein TYPA
PRL2021_RS07690	COG0242	peptide deformylase activity
PRL2021_RS07695	COG5503	Protein of unknown function (DUF1447)
PRL2021_RS07705	COG1597	lipid kinase activity
PRL2021_RS07715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PRL2021_RS07725	COG0406	alpha-ribazole phosphatase activity
PRL2021_RS07730	COG2801	Transposase and inactivated derivatives
PRL2021_RS07740	COG0482	sulfurtransferase activity
PRL2021_RS07750	COG1104	cysteine desulfurase activity
PRL2021_RS07765	COG0494	nUDIX hydrolase
PRL2021_RS07770	COG1278	Cold shock
PRL2021_RS07775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PRL2021_RS07795	COG1799	cell septum assembly
PRL2021_RS07800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PRL2021_RS07810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PRL2021_RS07815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PRL2021_RS07820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PRL2021_RS07825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PRL2021_RS07830	COG0768	penicillin binding
PRL2021_RS07840	COG0275	rRNA processing
PRL2021_RS07845	COG2001	Belongs to the MraZ family
PRL2021_RS07870	COG1792	Involved in formation and maintenance of cell shape
PRL2021_RS07875	COG1077	Cell shape determining protein MreB Mrl
PRL2021_RS07895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PRL2021_RS07905	COG0525	valine-tRNA ligase activity
PRL2021_RS07920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PRL2021_RS07940	COG0463	Glycosyl transferase, family 2
PRL2021_RS07960	COG1187	pseudouridine synthase activity
PRL2021_RS07970	COG0301	tRNA thio-modification
PRL2021_RS07975	COG1104	cysteine desulfurase activity
PRL2021_RS07980	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
PRL2021_RS07985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PRL2021_RS07995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PRL2021_RS08005	COG0589	response to stress
PRL2021_RS08010	COG0772	Belongs to the SEDS family
PRL2021_RS08020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PRL2021_RS08045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PRL2021_RS08050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PRL2021_RS08055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PRL2021_RS08060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PRL2021_RS08065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PRL2021_RS08070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PRL2021_RS08075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PRL2021_RS08080	COG0356	it plays a direct role in the translocation of protons across the membrane
PRL2021_RS08085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PRL2021_RS08090	COG0009	L-threonylcarbamoyladenylate synthase
PRL2021_RS08095	COG2890	protein-(glutamine-N5) methyltransferase activity
PRL2021_RS08100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PRL2021_RS08105	COG1435	thymidine kinase activity
PRL2021_RS08110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PRL2021_RS08125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PRL2021_RS08135	COG0477	Major facilitator Superfamily
PRL2021_RS08140	COG0166	Belongs to the GPI family
PRL2021_RS08150	COG1368	sulfuric ester hydrolase activity
PRL2021_RS08155	COG3850	Histidine kinase
PRL2021_RS08155	COG5002	protein histidine kinase activity
PRL2021_RS08160	COG0745	RESPONSE REGULATOR receiver
PRL2021_RS08185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PRL2021_RS08245	COG3414	Phosphotransferase system galactitol-specific IIB component
PRL2021_RS08250	COG3775	system Galactitol-specific IIC component
PRL2021_RS08470	COG3764	Sortase (surface protein transpeptidase)
PRL2021_RS08545	COG1396	sequence-specific DNA binding
PRL2021_RS08555	COG4974	Belongs to the 'phage' integrase family
PRL2021_RS08570	COG0827	DNA restriction-modification system
PRL2021_RS08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PRL2021_RS08610	COG0217	transcriptional regulatory protein
PRL2021_RS08630	COG2801	Transposase and inactivated derivatives
PRL2021_RS08640	COG0531	amino acid
PRL2021_RS08655	COG3706	GGDEF domain
PRL2021_RS08690	COG1263	PTS System
PRL2021_RS08690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS08690	COG2190	(PTS) system
PRL2021_RS08695	COG3711	transcriptional antiterminator
PRL2021_RS08700	COG1929	Belongs to the glycerate kinase type-1 family
PRL2021_RS08705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PRL2021_RS08720	COG0561	phosphatase activity
PRL2021_RS08725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PRL2021_RS08730	COG4856	YbbR-like protein
PRL2021_RS08750	COG1176	ABC-type spermidine putrescine transport system, permease component I
PRL2021_RS08755	COG3842	ATPase activity
PRL2021_RS08760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PRL2021_RS08770	COG0802	atpase or kinase
PRL2021_RS08775	COG0280	phosphate acetyltransferase
PRL2021_RS08780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PRL2021_RS08785	COG0561	phosphatase activity
PRL2021_RS08805	COG0149	triose-phosphate isomerase activity
PRL2021_RS08810	COG0126	phosphoglycerate kinase activity
PRL2021_RS08820	COG2390	Transcriptional regulator
PRL2021_RS08835	COG0531	amino acid
PRL2021_RS08850	COG2814	Major facilitator Superfamily
PRL2021_RS08870	COG0390	transport system, permease component
PRL2021_RS08885	COG0740	serine-type endopeptidase activity
PRL2021_RS08890	COG1481	regulation of sporulation
PRL2021_RS08895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PRL2021_RS08900	COG1660	Displays ATPase and GTPase activities
PRL2021_RS08910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PRL2021_RS08915	COG0556	nucleotide-excision repair
PRL2021_RS08920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PRL2021_RS08925	COG0492	ferredoxin-NADP+ reductase activity
PRL2021_RS08930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PRL2021_RS08935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PRL2021_RS08940	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PRL2021_RS08955	COG0653	protein targeting
PRL2021_RS08970	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PRL2021_RS08975	COG1739	Uncharacterized protein family UPF0029
PRL2021_RS08980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PRL2021_RS08985	COG1418	mRNA catabolic process
PRL2021_RS08990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PRL2021_RS08995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PRL2021_RS09000	COG1426	Protein conserved in bacteria
PRL2021_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
PRL2021_RS09010	COG0612	Peptidase, M16
PRL2021_RS09020	COG1280	lysine exporter protein (LysE YggA)
PRL2021_RS09020	COG1674	ftsk spoiiie
PRL2021_RS09035	COG0628	permease
PRL2021_RS09045	COG2706	6-phosphogluconolactonase activity
PRL2021_RS09065	COG0564	pseudouridine synthase activity
PRL2021_RS09070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PRL2021_RS09075	COG2357	RelA SpoT domain protein
PRL2021_RS09095	COG4862	establishment of competence for transformation
PRL2021_RS09100	COG1393	Belongs to the ArsC family
PRL2021_RS09110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PRL2021_RS09120	COG0542	response to heat
PRL2021_RS09130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PRL2021_RS09155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PRL2021_RS09175	COG3425	synthase
PRL2021_RS09185	COG0183	Belongs to the thiolase family
PRL2021_RS09190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PRL2021_RS09195	COG1295	ribonuclease BN
PRL2021_RS09200	COG0024	Methionine aminopeptidase
PRL2021_RS09205	COG0716	FMN binding
PRL2021_RS09225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PRL2021_RS09240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PRL2021_RS09255	COG0531	amino acid
PRL2021_RS09260	COG3976	FMN-binding domain protein
PRL2021_RS09260	COG1053	succinate dehydrogenase
PRL2021_RS09285	COG1253	flavin adenine dinucleotide binding
PRL2021_RS09300	COG2190	(PTS) system
PRL2021_RS09300	COG1263	PTS System
PRL2021_RS09300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS09310	COG1737	Transcriptional regulator
PRL2021_RS09315	COG1263	PTS System
PRL2021_RS09315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRL2021_RS09320	COG0561	phosphatase activity
PRL2021_RS09330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PRL2021_RS09345	COG0561	phosphatase activity
PRL2021_RS09350	COG2188	Transcriptional regulator
PRL2021_RS09360	COG3158	transport of potassium into the cell
PRL2021_RS09365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PRL2021_RS09420	COG0765	amino acid transport
PRL2021_RS09425	COG0765	amino acid transport
PRL2021_RS09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRL2021_RS09440	COG0572	uridine kinase
PRL2021_RS09460	COG1132	(ABC) transporter
PRL2021_RS09465	COG1132	(ABC) transporter
PRL2021_RS09475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRL2021_RS09480	COG0519	Catalyzes the synthesis of GMP from XMP
PRL2021_RS09485	COG0531	amino acid
PRL2021_RS09490	COG0531	amino acid
PRL2021_RS09500	COG3344	reverse transcriptase
PRL2021_RS09505	COG4989	oxidoreductase activity
PRL2021_RS09510	COG0488	(ABC) transporter
PRL2021_RS09540	COG0477	Major facilitator Superfamily
PRL2021_RS09565	COG0656	L-ascorbic acid biosynthetic process
PRL2021_RS09620	COG2801	Transposase and inactivated derivatives
PRL2021_RS09625	COG4716	Myosin-crossreactive antigen
PRL2021_RS09635	COG2814	Major facilitator Superfamily
PRL2021_RS09665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PRL2021_RS09675	COG1757	Na H antiporter
PRL2021_RS09705	COG1597	lipid kinase activity
PRL2021_RS09710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PRL2021_RS09715	COG0154	amidase activity
PRL2021_RS09720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PRL2021_RS09725	COG4851	CamS sex pheromone cAM373 precursor
PRL2021_RS09730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PRL2021_RS09740	COG1705	Flagellar rod assembly protein muramidase FlgJ
PRL2021_RS09750	COG3091	SprT-like family
PRL2021_RS09790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PRL2021_RS09800	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PRL2021_RS09820	COG2188	Transcriptional regulator
PRL2021_RS09830	COG4166	transmembrane transport
PRL2021_RS09845	COG0446	pyridine nucleotide-disulphide oxidoreductase
PRL2021_RS09865	COG1737	Transcriptional regulator
PRL2021_RS09870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PRL2021_RS09875	COG0673	inositol 2-dehydrogenase activity
PRL2021_RS09880	COG0436	Aminotransferase
PRL2021_RS09890	COG2801	Transposase and inactivated derivatives
PRL2021_RS09895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PRL2021_RS09915	COG0406	alpha-ribazole phosphatase activity
PRL2021_RS09920	COG0588	phosphoglycerate mutase activity
PRL2021_RS09935	COG2801	Transposase and inactivated derivatives
PRL2021_RS09970	COG0110	maltose O-acetyltransferase activity
PRL2021_RS09985	COG0778	Nitroreductase
PRL2021_RS10010	COG1111	helicase
PRL2021_RS10010	COG1205	dead DEAH box helicase
PRL2021_RS10030	COG1132	(ABC) transporter
PRL2021_RS10065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PRL2021_RS10070	COG2213	PTS system mannitol-specific
PRL2021_RS10075	COG3711	transcriptional antiterminator
PRL2021_RS10080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PRL2021_RS10090	COG1113	amino acid transport
PRL2021_RS10100	COG0110	maltose O-acetyltransferase activity
PRL2021_RS10105	COG0583	DNA-binding transcription factor activity
PRL2021_RS10115	COG3716	PTS system mannose fructose sorbose family IID component
PRL2021_RS10120	COG3715	PTS system
PRL2021_RS10185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PRL2021_RS10190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PRL2021_RS10195	COG0398	Pfam SNARE associated Golgi protein
PRL2021_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
PRL2021_RS10225	COG2409	Drug exporters of the RND superfamily
PRL2021_RS10225	COG1033	growth of symbiont in host cell
PRL2021_RS10260	COG1175	transmembrane transport
PRL2021_RS10280	COG2176	DNA-directed DNA polymerase activity
PRL2021_RS10310	COG2801	Transposase and inactivated derivatives
PRL2021_RS10355	COG1132	(ABC) transporter
PRL2021_RS10365	COG2267	carboxylic ester hydrolase activity
PRL2021_RS10370	COG0745	RESPONSE REGULATOR receiver
PRL2021_RS10375	COG5002	protein histidine kinase activity
PRL2021_RS10395	COG1846	Transcriptional regulator
PRL2021_RS10400	COG1132	(ABC) transporter
PRL2021_RS10415	COG4166	transmembrane transport
PRL2021_RS10430	COG0675	Transposase, IS605 OrfB family
PRL2021_RS10445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PRL2021_RS10450	COG1072	(Pantothenic acid kinase))
PRL2021_RS10460	COG2153	protein acetylation
PRL2021_RS10465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRL2021_RS10470	COG1126	abc transporter atp-binding protein
PRL2021_RS10475	COG0765	amino acid transport
PRL2021_RS10480	COG3973	AAA domain
PRL2021_RS10490	COG0588	phosphoglycerate mutase activity
PRL2021_RS10540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PRL2021_RS10555	COG0791	NLP P60 protein
PRL2021_RS10560	COG0791	NLP P60 protein
PRL2021_RS10565	COG0791	NLP P60 protein
PRL2021_RS10570	COG0194	GDP metabolic process
PRL2021_RS10610	COG4990	cell redox homeostasis
PRL2021_RS10630	COG0488	(ABC) transporter
PRL2021_RS10640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PRL2021_RS10650	COG1811	Na channel or pump
PRL2021_RS10655	COG1316	TRANSCRIPTIONal
PRL2021_RS10660	COG1164	Oligoendopeptidase f
PRL2021_RS10695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRL2021_RS10700	COG2274	protein secretion by the type I secretion system
PRL2021_RS10705	COG3279	Response regulator of the LytR AlgR family
PRL2021_RS10730	COG1476	TRANSCRIPTIONal
PRL2021_RS10740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PRL2021_RS10745	COG1854	S-ribosylhomocysteine lyase activity
PRL2021_RS10780	COG1620	l-lactate permease
PRL2021_RS10795	COG1121	(ABC) transporter
PRL2021_RS10805	COG0640	Transcriptional regulator
PRL2021_RS10810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PRL2021_RS10810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PRL2021_RS10810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PRL2021_RS10815	COG1105	Belongs to the carbohydrate kinase PfkB family
PRL2021_RS10825	COG1668	transmembrane transport
PRL2021_RS10830	COG4152	abc transporter atp-binding protein
PRL2021_RS10845	COG3655	Transcriptional regulator
PRL2021_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRL2021_RS10890	COG2274	protein secretion by the type I secretion system
PRL2021_RS10915	COG0277	FAD linked oxidase domain protein
PRL2021_RS10935	COG1794	racemase activity, acting on amino acids and derivatives
PRL2021_RS10940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PRL2021_RS10955	COG1132	(ABC) transporter
PRL2021_RS10970	COG0012	GTP binding
PRL2021_RS10975	COG4481	Protein conserved in bacteria
PRL2021_RS10980	COG1475	DNA binding
PRL2021_RS10985	COG1192	Involved in chromosome partitioning
PRL2021_RS10990	COG1475	DNA binding
PRL2021_RS10995	COG0357	Ribosomal RNA small subunit methyltransferase G
PRL2021_RS11015	COG0431	NADPH-dependent FMN reductase
PRL2021_RS11020	COG0431	NADPH-dependent FMN reductase
PRL2021_RS11045	COG1136	(ABC) transporter
PRL2021_RS11060	COG0406	alpha-ribazole phosphatase activity
PRL2021_RS11070	COG3022	response to hydroperoxide
PRL2021_RS11080	COG3104	oligopeptide transport
PRL2021_RS11120	COG3104	oligopeptide transport
PRL2021_RS11150	COG5002	protein histidine kinase activity
PRL2021_RS11165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PRL2021_RS11170	COG0581	inorganic phosphate transmembrane transporter activity
PRL2021_RS11175	COG0573	inorganic phosphate transmembrane transporter activity
PRL2021_RS11180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PRL2021_RS11190	COG0671	phosphoesterase, PA-phosphatase related
PRL2021_RS11195	COG3344	reverse transcriptase
PRL2021_RS11200	COG0308	aminopeptidase N
PRL2021_RS11255	COG3833	ABC-type maltose transport systems, permease component
PRL2021_RS11260	COG1175	transmembrane transport
PRL2021_RS11270	COG3842	ATPase activity
PRL2021_RS11275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PRL2021_RS11290	COG0366	Alpha amylase catalytic
PRL2021_RS11300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PRL2021_RS11305	COG1609	Transcriptional regulator
PRL2021_RS11310	COG2365	Tyrosine phosphatase family
PRL2021_RS11315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PRL2021_RS11320	COG0351	phosphomethylpyrimidine kinase
PRL2021_RS11370	COG3442	glutamine amidotransferase
PRL2021_RS11425	COG0488	(ABC) transporter
PRL2021_RS11460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PRL2021_RS11465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PRL2021_RS11470	COG0516	GMP reductase activity
PRL2021_RS11495	COG2502	aspartate--ammonia ligase
PRL2021_RS11505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PRL2021_RS11525	COG1113	amino acid transport
PRL2021_RS11530	COG1113	amino acid transport
PRL2021_RS11535	COG0681	Belongs to the peptidase S26 family
PRL2021_RS11540	COG0542	response to heat
PRL2021_RS11570	COG2244	polysaccharide biosynthetic process
PRL2021_RS11590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PRL2021_RS11595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PRL2021_RS11600	COG1696	Membrane protein involved in D-alanine export
PRL2021_RS11605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PRL2021_RS11625	COG0517	IMP dehydrogenase activity
PRL2021_RS11625	COG0516	GMP reductase activity
PRL2021_RS11630	COG2217	Heavy metal translocating P-type atpase
PRL2021_RS11640	COG2161	toxin-antitoxin pair type II binding
PRL2021_RS11645	COG4115	mRNA cleavage
PRL2021_RS11670	COG1396	sequence-specific DNA binding
PRL2021_RS11685	COG1136	(ABC) transporter
PRL2021_RS11685	COG0577	efflux transmembrane transporter activity
PRL2021_RS11695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PRL2021_RS11705	COG1744	ABC transporter substrate-binding protein PnrA-like
PRL2021_RS11710	COG1744	ABC transporter substrate-binding protein PnrA-like
PRL2021_RS11715	COG3845	ABC transporter
PRL2021_RS11720	COG4603	Belongs to the binding-protein-dependent transport system permease family
PRL2021_RS11725	COG1079	Belongs to the binding-protein-dependent transport system permease family
PRL2021_RS11735	COG0363	glucosamine-6-phosphate deaminase activity
PRL2021_RS11740	COG1428	Deoxynucleoside kinase
PRL2021_RS11745	COG1428	Deoxynucleoside kinase
PRL2021_RS11765	COG0561	phosphatase activity
PRL2021_RS11770	COG2252	PERMEase
PRL2021_RS11785	COG1131	(ABC) transporter
PRL2021_RS11805	COG0789	Transcriptional regulator
PRL2021_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
PRL2021_RS11850	COG1373	ATPase (AAA superfamily
PRL2021_RS11860	COG2252	PERMEase
PRL2021_RS11880	COG1132	(ABC) transporter
PRL2021_RS11915	COG2217	Heavy metal translocating P-type atpase
PRL2021_RS11920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PRL2021_RS11930	COG0477	Major facilitator Superfamily
PRL2021_RS11985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PRL2021_RS11995	COG0028	Belongs to the TPP enzyme family
PRL2021_RS12005	COG0445	tRNA wobble uridine modification
PRL2021_RS12010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PRL2021_RS12015	COG0706	membrane insertase activity
PRL2021_RS12020	COG0594	ribonuclease P activity
PRL2021_RS12025	COG0230	Belongs to the bacterial ribosomal protein bL34 family