locus-tag	class	description
DT351_RS00005	COG0592	DNA-directed DNA polymerase activity
DT351_RS00010	COG2501	S4 domain
DT351_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DT351_RS00020	COG0187	DNA topoisomerase II activity
DT351_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DT351_RS00030	COG0360	Binds together with S18 to 16S ribosomal RNA
DT351_RS00035	COG0629	single-stranded DNA binding
DT351_RS00040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DT351_RS00050	COG0359	binds to the 23S rRNA
DT351_RS00055	COG0305	Participates in initiation and elongation during chromosome replication
DT351_RS00060	COG0438	transferase activity, transferring glycosyl groups
DT351_RS00070	COG2233	PERMEase
DT351_RS00075	COG0357	Ribosomal RNA small subunit methyltransferase G
DT351_RS00080	COG1475	DNA binding
DT351_RS00085	COG1192	Involved in chromosome partitioning
DT351_RS00090	COG1475	DNA binding
DT351_RS00095	COG4481	Protein conserved in bacteria
DT351_RS00100	COG0012	GTP binding
DT351_RS00110	COG1073	alpha beta
DT351_RS00120	COG1780	Probably involved in ribonucleotide reductase function
DT351_RS00145	COG1307	EDD domain protein, DegV family
DT351_RS00150	COG1253	flavin adenine dinucleotide binding
DT351_RS00155	COG0656	L-ascorbic acid biosynthetic process
DT351_RS00195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DT351_RS00200	COG2365	Tyrosine phosphatase family
DT351_RS00215	COG0519	Catalyzes the synthesis of GMP from XMP
DT351_RS00225	COG1121	(ABC) transporter
DT351_RS00235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DT351_RS00260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DT351_RS00265	COG0628	permease
DT351_RS00280	COG1181	Belongs to the D-alanine--D-alanine ligase family
DT351_RS00295	COG4152	abc transporter atp-binding protein
DT351_RS00300	COG1668	transmembrane transport
DT351_RS00310	COG3590	peptidase
DT351_RS00315	COG0110	maltose O-acetyltransferase activity
DT351_RS00320	COG0352	thiamine-phosphate diphosphorylase activity
DT351_RS00325	COG0351	phosphomethylpyrimidine kinase
DT351_RS00330	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DT351_RS00345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DT351_RS00350	COG2252	PERMEase
DT351_RS00355	COG3764	Sortase (surface protein transpeptidase)
DT351_RS00375	COG0745	RESPONSE REGULATOR receiver
DT351_RS00395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DT351_RS00400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DT351_RS00415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DT351_RS00435	COG2814	Major facilitator Superfamily
DT351_RS00440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DT351_RS00445	COG1125	glycine betaine transport
DT351_RS00445	COG0517	IMP dehydrogenase activity
DT351_RS00450	COG1174	glycine betaine transport
DT351_RS00465	COG0110	maltose O-acetyltransferase activity
DT351_RS00480	COG0588	phosphoglycerate mutase activity
DT351_RS00510	COG1881	PFAM PEBP family protein
DT351_RS00525	COG0514	ATP-dependent DNA helicase (RecQ)
DT351_RS00535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DT351_RS00615	COG4869	propanediol catabolic process
DT351_RS00650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DT351_RS00725	COG2261	transglycosylase associated protein
DT351_RS00805	COG1063	alcohol dehydrogenase
DT351_RS00810	COG0693	protein deglycase activity
DT351_RS00820	COG0604	alcohol dehydrogenase
DT351_RS00820	COG3321	synthase
DT351_RS00825	COG2837	iron assimilation
DT351_RS00830	COG0028	Belongs to the TPP enzyme family
DT351_RS00835	COG0398	Pfam SNARE associated Golgi protein
DT351_RS00840	COG1757	Na H antiporter
DT351_RS00860	COG1959	2 iron, 2 sulfur cluster binding
DT351_RS00870	COG0833	amino acid
DT351_RS00890	COG1428	Deoxynucleoside kinase
DT351_RS00900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DT351_RS00905	COG1511	domain protein
DT351_RS00910	COG2188	Transcriptional regulator
DT351_RS00920	COG2723	6-phospho-beta-galactosidase activity
DT351_RS00940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DT351_RS01020	COG4463	regulation of RNA biosynthetic process
DT351_RS01025	COG0542	response to heat
DT351_RS01030	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DT351_RS01035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DT351_RS01045	COG0085	RNA polymerase activity
DT351_RS01050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DT351_RS01060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DT351_RS01065	COG0049	tRNA binding
DT351_RS01070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DT351_RS01075	COG1162	GTPase activity
DT351_RS01080	COG1335	isochorismatase
DT351_RS01085	COG0051	transcription antitermination factor activity, RNA binding
DT351_RS01090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DT351_RS01095	COG0088	Forms part of the polypeptide exit tunnel
DT351_RS01100	COG0089	rRNA binding
DT351_RS01105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DT351_RS01110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DT351_RS01115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DT351_RS01120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DT351_RS01125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DT351_RS01130	COG0255	Belongs to the universal ribosomal protein uL29 family
DT351_RS01135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DT351_RS01140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DT351_RS01145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DT351_RS01150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DT351_RS01160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DT351_RS01165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DT351_RS01170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DT351_RS01175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DT351_RS01180	COG1841	ribosomal large subunit assembly
DT351_RS01185	COG0200	Binds to the 23S rRNA
DT351_RS01195	COG0563	adenylate kinase activity
DT351_RS01200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DT351_RS01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DT351_RS01210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DT351_RS01215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DT351_RS01220	COG0202	RNA polymerase activity
DT351_RS01225	COG0203	ribosomal protein L17
DT351_RS01230	COG1122	ATPase activity
DT351_RS01235	COG1122	ATPase activity
DT351_RS01250	COG0101	tRNA pseudouridine synthase activity
DT351_RS01255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DT351_RS01260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DT351_RS01325	COG2801	Transposase and inactivated derivatives
DT351_RS01340	COG1597	lipid kinase activity
DT351_RS01345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS01350	COG2723	6-phospho-beta-galactosidase activity
DT351_RS01355	COG2188	Transcriptional regulator
DT351_RS01360	COG0640	Transcriptional regulator
DT351_RS01380	COG0778	Nitroreductase
DT351_RS01440	COG3479	Phenolic acid decarboxylase
DT351_RS01470	COG0488	(ABC) transporter
DT351_RS01490	COG3118	belongs to the thioredoxin family
DT351_RS01510	COG1737	Transcriptional regulator
DT351_RS01515	COG1486	melibiose metabolic process
DT351_RS01525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS01530	COG2723	6-phospho-beta-galactosidase activity
DT351_RS01560	COG0702	epimerase
DT351_RS01565	COG1760	l-serine dehydratase
DT351_RS01575	COG1297	OPT oligopeptide transporter protein
DT351_RS01590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DT351_RS01595	COG1136	(ABC) transporter
DT351_RS01625	COG0561	phosphatase activity
DT351_RS01665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DT351_RS01675	COG0250	Participates in transcription elongation, termination and antitermination
DT351_RS01685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DT351_RS01690	COG0081	regulation of translation
DT351_RS01695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DT351_RS01700	COG2252	PERMEase
DT351_RS01705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DT351_RS01710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DT351_RS01715	COG0222	ribosome binding
DT351_RS01755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS01755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS01775	COG1396	sequence-specific DNA binding
DT351_RS01785	COG4974	Belongs to the 'phage' integrase family
DT351_RS01790	COG0392	lysyltransferase activity
DT351_RS01790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DT351_RS01795	COG2813	Specifically methylates the guanine in position
DT351_RS01805	COG0590	tRNA wobble adenosine to inosine editing
DT351_RS01815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DT351_RS01820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DT351_RS01825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DT351_RS01835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DT351_RS01840	COG3870	Protein conserved in bacteria
DT351_RS01845	COG0470	DNA polymerase III
DT351_RS01850	COG4467	Involved in initiation control of chromosome replication
DT351_RS01870	COG4720	Psort location CytoplasmicMembrane, score
DT351_RS01875	COG1214	PFAM Peptidase M22, glycoprotease
DT351_RS01885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DT351_RS01890	COG3973	AAA domain
DT351_RS01900	COG0534	Mate efflux family protein
DT351_RS01910	COG4989	oxidoreductase activity
DT351_RS01920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DT351_RS01950	COG1801	Protein of unknown function DUF72
DT351_RS01955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT351_RS01955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT351_RS01960	COG0084	hydrolase, TatD family'
DT351_RS01965	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DT351_RS01970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DT351_RS01975	COG4466	Protein conserved in bacteria
DT351_RS01980	COG1511	domain protein
DT351_RS01985	COG1846	Transcriptional regulator
DT351_RS01990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DT351_RS01995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DT351_RS02000	COG2376	Dihydroxyacetone kinase
DT351_RS02005	COG1461	Dihydroxyacetone kinase
DT351_RS02010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DT351_RS02015	COG1088	dTDP-glucose 4,6-dehydratase activity
DT351_RS02025	COG1376	ErfK ybiS ycfS ynhG family protein
DT351_RS02030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DT351_RS02040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DT351_RS02045	COG1970	mechanosensitive ion channel activity
DT351_RS02050	COG0861	Integral membrane protein TerC family
DT351_RS02070	COG1078	dGTPase activity
DT351_RS02085	COG3343	RNA polymerase activity
DT351_RS02090	COG1940	carbohydrate kinase activity
DT351_RS02095	COG0504	CTP synthase activity
DT351_RS02100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DT351_RS02105	COG0254	rRNA binding
DT351_RS02120	COG3548	integral membrane protein
DT351_RS02130	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS02140	COG2814	Major facilitator Superfamily
DT351_RS02150	COG1704	LemA family
DT351_RS02155	COG0501	Belongs to the peptidase M48B family
DT351_RS02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DT351_RS02175	COG0736	holo-[acyl-carrier-protein] synthase activity
DT351_RS02180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DT351_RS02190	COG2337	Toxic component of a toxin-antitoxin (TA) module
DT351_RS02195	COG4708	membrane
DT351_RS02210	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS02215	COG0039	L-malate dehydrogenase activity
DT351_RS02220	COG0193	aminoacyl-tRNA hydrolase activity
DT351_RS02225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DT351_RS02230	COG2244	polysaccharide biosynthetic process
DT351_RS02235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DT351_RS02245	COG1098	S1 RNA binding domain
DT351_RS02250	COG0037	tRNA processing
DT351_RS02255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DT351_RS02265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DT351_RS02270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DT351_RS02275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DT351_RS02315	COG3104	oligopeptide transport
DT351_RS02330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DT351_RS02340	COG2801	Transposase and inactivated derivatives
DT351_RS02360	COG2188	Transcriptional regulator
DT351_RS02375	COG3328	transposase activity
DT351_RS02380	COG1388	LysM domain
DT351_RS02380	COG1705	Flagellar rod assembly protein muramidase FlgJ
DT351_RS02435	COG0463	Glycosyl transferase, family 2
DT351_RS02440	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DT351_RS02450	COG1088	dTDP-glucose 4,6-dehydratase activity
DT351_RS02460	COG1216	Glycosyl transferase, family 2
DT351_RS02470	COG0562	UDP-galactopyranose mutase
DT351_RS02475	COG2244	polysaccharide biosynthetic process
DT351_RS02480	COG1091	dTDP-4-dehydrorhamnose reductase activity
DT351_RS02490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DT351_RS02495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DT351_RS02515	COG2183	response to ionizing radiation
DT351_RS02520	COG3091	SprT-like family
DT351_RS02545	COG1278	Cold shock
DT351_RS02555	COG0673	inositol 2-dehydrogenase activity
DT351_RS02560	COG1705	Flagellar rod assembly protein muramidase FlgJ
DT351_RS02565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DT351_RS02570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DT351_RS02575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DT351_RS02580	COG1609	Transcriptional regulator
DT351_RS02585	COG0561	phosphatase activity
DT351_RS02595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DT351_RS02600	COG4851	CamS sex pheromone cAM373 precursor
DT351_RS02615	COG1959	2 iron, 2 sulfur cluster binding
DT351_RS02630	COG0154	amidase activity
DT351_RS02635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DT351_RS02640	COG1597	lipid kinase activity
DT351_RS02645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DT351_RS02685	COG0673	inositol 2-dehydrogenase activity
DT351_RS02695	COG1447	Phosphotransferase system cellobiose-specific component IIA
DT351_RS02705	COG2723	6-phospho-beta-galactosidase activity
DT351_RS02710	COG1827	regulation of RNA biosynthetic process
DT351_RS02715	COG0477	Major facilitator Superfamily
DT351_RS02735	COG2076	Multidrug Resistance protein
DT351_RS02750	COG2309	aminopeptidase activity
DT351_RS02760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DT351_RS02765	COG0463	Glycosyl transferase, family 2
DT351_RS02770	COG2246	polysaccharide biosynthetic process
DT351_RS02775	COG2246	polysaccharide biosynthetic process
DT351_RS02780	COG0716	FMN binding
DT351_RS02785	COG0024	Methionine aminopeptidase
DT351_RS02795	COG1316	TRANSCRIPTIONal
DT351_RS02805	COG0489	protein tyrosine kinase activity
DT351_RS02810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DT351_RS02820	COG3475	LICD family
DT351_RS02830	COG1216	Glycosyl transferase, family 2
DT351_RS02835	COG0562	UDP-galactopyranose mutase
DT351_RS02840	COG2244	polysaccharide biosynthetic process
DT351_RS02845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DT351_RS02860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DT351_RS02865	COG0242	peptide deformylase activity
DT351_RS02870	COG0765	amino acid transport
DT351_RS02905	COG0183	Belongs to the thiolase family
DT351_RS02915	COG3425	synthase
DT351_RS02935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DT351_RS02945	COG2137	regulation of response to DNA damage stimulus
DT351_RS02950	COG1194	a g-specific adenine glycosylase
DT351_RS02955	COG3557	Belongs to the UPF0374 family
DT351_RS02970	COG0628	permease
DT351_RS02975	COG1253	flavin adenine dinucleotide binding
DT351_RS02980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DT351_RS03000	COG0542	response to heat
DT351_RS03025	COG2217	Heavy metal translocating P-type atpase
DT351_RS03035	COG0602	queuosine metabolic process
DT351_RS03050	COG2205	protein histidine kinase activity
DT351_RS03055	COG0745	RESPONSE REGULATOR receiver
DT351_RS03060	COG1136	(ABC) transporter
DT351_RS03065	COG0577	efflux transmembrane transporter activity
DT351_RS03075	COG1234	tRNA 3'-trailer cleavage
DT351_RS03080	COG1393	Belongs to the ArsC family
DT351_RS03085	COG4862	establishment of competence for transformation
DT351_RS03105	COG2357	RelA SpoT domain protein
DT351_RS03110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DT351_RS03115	COG0564	pseudouridine synthase activity
DT351_RS03120	COG1968	undecaprenyl-diphosphatase activity
DT351_RS03125	COG3142	Participates in the control of copper homeostasis
DT351_RS03130	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DT351_RS03135	COG0671	phosphoesterase, PA-phosphatase related
DT351_RS03140	COG1705	Flagellar rod assembly protein muramidase FlgJ
DT351_RS03140	COG1388	LysM domain
DT351_RS03145	COG0495	leucyl-tRNA aminoacylation
DT351_RS03150	COG1113	amino acid transport
DT351_RS03155	COG1733	regulation of RNA biosynthetic process
DT351_RS03165	COG2244	polysaccharide biosynthetic process
DT351_RS03170	COG1187	pseudouridine synthase activity
DT351_RS03175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DT351_RS03240	COG1061	Type III restriction enzyme res subunit
DT351_RS03450	COG0561	phosphatase activity
DT351_RS03455	COG2267	carboxylic ester hydrolase activity
DT351_RS03460	COG0531	amino acid
DT351_RS03475	COG0577	efflux transmembrane transporter activity
DT351_RS03475	COG1136	(ABC) transporter
DT351_RS03480	COG0018	arginyl-trna synthetase
DT351_RS03485	COG1073	alpha beta
DT351_RS03500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DT351_RS03510	COG0557	exoribonuclease II activity
DT351_RS03515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DT351_RS03520	COG3584	3D domain protein
DT351_RS03520	COG3583	domain protein
DT351_RS03535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DT351_RS03540	COG0237	dephospho-CoA kinase activity
DT351_RS03545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DT351_RS03550	COG3611	Membrane attachment protein
DT351_RS03555	COG1484	DNA-dependent DNA replication
DT351_RS03560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DT351_RS03565	COG1304	FMN binding
DT351_RS03570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DT351_RS03575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DT351_RS03580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DT351_RS03585	COG1063	alcohol dehydrogenase
DT351_RS03590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DT351_RS03595	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DT351_RS03605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DT351_RS03610	COG1713	HD superfamily hydrolase involved in NAD metabolism
DT351_RS03615	COG0799	negative regulation of ribosome biogenesis
DT351_RS03620	COG2226	methyltransferase
DT351_RS03625	COG1323	Belongs to the UPF0348 family
DT351_RS03635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DT351_RS03640	COG0745	RESPONSE REGULATOR receiver
DT351_RS03645	COG5002	protein histidine kinase activity
DT351_RS03650	COG0706	membrane insertase activity
DT351_RS03655	COG1254	Belongs to the acylphosphatase family
DT351_RS03660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DT351_RS03670	COG1733	regulation of RNA biosynthetic process
DT351_RS03675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DT351_RS03680	COG0072	phenylalanine-tRNA ligase activity
DT351_RS03685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DT351_RS03690	COG0572	uridine kinase
DT351_RS03695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DT351_RS03705	COG4585	Histidine kinase
DT351_RS03715	COG4841	protein insertion into membrane
DT351_RS03725	COG0604	alcohol dehydrogenase
DT351_RS03730	COG3842	ATPase activity
DT351_RS03735	COG1176	ABC-type spermidine putrescine transport system, permease component I
DT351_RS03740	COG1177	transmembrane transport
DT351_RS03760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DT351_RS03770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DT351_RS03775	COG4475	Protein of unknown function (DUF436)
DT351_RS03785	COG0351	phosphomethylpyrimidine kinase
DT351_RS03790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DT351_RS03815	COG0561	phosphatase activity
DT351_RS03820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DT351_RS03825	COG0280	phosphate acetyltransferase
DT351_RS03830	COG0802	atpase or kinase
DT351_RS03840	COG0697	spore germination
DT351_RS03845	COG2176	DNA-directed DNA polymerase activity
DT351_RS03850	COG0708	Exodeoxyribonuclease III
DT351_RS03855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DT351_RS03870	COG0768	penicillin binding
DT351_RS03875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DT351_RS03880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DT351_RS03895	COG1940	carbohydrate kinase activity
DT351_RS03910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DT351_RS03915	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DT351_RS03930	COG0789	Transcriptional regulator
DT351_RS03935	COG0174	glutamine synthetase
DT351_RS03940	COG2249	NAD(P)H dehydrogenase (quinone) activity
DT351_RS03945	COG0431	NADPH-dependent FMN reductase
DT351_RS03950	COG0564	pseudouridine synthase activity
DT351_RS03960	COG0534	Mate efflux family protein
DT351_RS03965	COG0583	DNA-binding transcription factor activity
DT351_RS03970	COG2855	membrane
DT351_RS04000	COG0217	transcriptional regulatory protein
DT351_RS04005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DT351_RS04010	COG1459	type II secretion system
DT351_RS04035	COG0827	DNA restriction-modification system
DT351_RS04040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DT351_RS04055	COG3152	Membrane
DT351_RS04080	COG0481	GTPase activity
DT351_RS04120	COG2801	Transposase and inactivated derivatives
DT351_RS04130	COG0393	Putative heavy-metal-binding
DT351_RS04135	COG3759	membrane
DT351_RS04140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DT351_RS04145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DT351_RS04145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DT351_RS04150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DT351_RS04155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DT351_RS04160	COG4224	UPF0291 protein
DT351_RS04165	COG3763	UPF0154 protein
DT351_RS04170	COG1132	(ABC) transporter
DT351_RS04175	COG1132	(ABC) transporter
DT351_RS04180	COG1073	alpha beta
DT351_RS04190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DT351_RS04200	COG0204	Acyl-transferase
DT351_RS04205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DT351_RS04210	COG2827	Endonuclease containing a URI domain
DT351_RS04215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DT351_RS04220	COG0052	Belongs to the universal ribosomal protein uS2 family
DT351_RS04225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DT351_RS04230	COG0528	UMP kinase activity
DT351_RS04235	COG0233	cytoplasmic translational termination
DT351_RS04245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DT351_RS04250	COG4589	Belongs to the CDS family
DT351_RS04255	COG0750	zinc metalloprotease
DT351_RS04260	COG0442	prolyl-tRNA aminoacylation
DT351_RS04265	COG2176	DNA-directed DNA polymerase activity
DT351_RS04275	COG2801	Transposase and inactivated derivatives
DT351_RS04290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DT351_RS04300	COG0195	Participates in both transcription termination and antitermination
DT351_RS04305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DT351_RS04315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DT351_RS04320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DT351_RS04330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DT351_RS04335	COG0196	riboflavin kinase activity
DT351_RS04340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DT351_RS04350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DT351_RS04355	COG0443	Heat shock 70 kDa protein
DT351_RS04370	COG0531	amino acid
DT351_RS04380	COG0745	RESPONSE REGULATOR receiver
DT351_RS04385	COG3850	Histidine kinase
DT351_RS04385	COG5002	protein histidine kinase activity
DT351_RS04390	COG0402	S-adenosylhomocysteine deaminase activity
DT351_RS04410	COG1368	sulfuric ester hydrolase activity
DT351_RS04425	COG4975	Glucose uptake
DT351_RS04430	COG4485	Bacterial membrane protein, YfhO
DT351_RS04435	COG2814	Major facilitator Superfamily
DT351_RS04455	COG2188	Transcriptional regulator
DT351_RS04465	COG0366	Alpha amylase catalytic
DT351_RS04470	COG2190	(PTS) system
DT351_RS04470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DT351_RS04470	COG1263	PTS System
DT351_RS04475	COG3394	polysaccharide catabolic process
DT351_RS04515	COG1733	regulation of RNA biosynthetic process
DT351_RS04520	COG4221	oxidoreductase activity
DT351_RS04530	COG0028	Belongs to the TPP enzyme family
DT351_RS04535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DT351_RS04540	COG4120	Belongs to the binding-protein-dependent transport system permease family
DT351_RS04550	COG0166	Belongs to the GPI family
DT351_RS04575	COG4990	cell redox homeostasis
DT351_RS04585	COG0589	response to stress
DT351_RS04600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DT351_RS04605	COG2723	6-phospho-beta-galactosidase activity
DT351_RS04615	COG3158	transport of potassium into the cell
DT351_RS04630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT351_RS04670	COG1803	Methylglyoxal synthase
DT351_RS04695	COG0577	efflux transmembrane transporter activity
DT351_RS04700	COG0577	efflux transmembrane transporter activity
DT351_RS04700	COG1136	(ABC) transporter
DT351_RS04720	COG1132	(ABC) transporter
DT351_RS04725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DT351_RS04730	COG1482	cell wall glycoprotein biosynthetic process
DT351_RS04735	COG1418	mRNA catabolic process
DT351_RS04745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DT351_RS04750	COG0517	IMP dehydrogenase activity
DT351_RS04755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DT351_RS04755	COG0574	Belongs to the PEP-utilizing enzyme family
DT351_RS04760	COG3442	glutamine amidotransferase
DT351_RS04765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DT351_RS04770	COG1435	thymidine kinase activity
DT351_RS04775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DT351_RS04780	COG2890	protein-(glutamine-N5) methyltransferase activity
DT351_RS04785	COG0009	L-threonylcarbamoyladenylate synthase
DT351_RS04790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DT351_RS04795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DT351_RS04800	COG0356	it plays a direct role in the translocation of protons across the membrane
DT351_RS04805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DT351_RS04810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DT351_RS04815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DT351_RS04820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DT351_RS04825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DT351_RS04830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DT351_RS04835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DT351_RS04845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DT351_RS04860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DT351_RS04870	COG0772	Belongs to the SEDS family
DT351_RS04875	COG0509	glycine decarboxylation via glycine cleavage system
DT351_RS04880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DT351_RS04885	COG2011	ABC-type metal ion transport system permease component
DT351_RS04890	COG1464	Belongs to the NlpA lipoprotein family
DT351_RS04900	COG1518	maintenance of DNA repeat elements
DT351_RS04925	COG0719	Fe-S assembly protein
DT351_RS04930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DT351_RS04940	COG0719	Fe-S assembly protein
DT351_RS04950	COG1268	BioY protein
DT351_RS04975	COG1956	GAF domain-containing protein
DT351_RS05000	COG5294	Protein conserved in bacteria
DT351_RS05010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DT351_RS05030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DT351_RS05045	COG4493	Belongs to the UPF0637 family
DT351_RS05050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DT351_RS05055	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DT351_RS05060	COG1104	cysteine desulfurase activity
DT351_RS05065	COG0301	tRNA thio-modification
DT351_RS05070	COG0525	valine-tRNA ligase activity
DT351_RS05080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DT351_RS05085	COG2003	Belongs to the UPF0758 family
DT351_RS05090	COG1077	Cell shape determining protein MreB Mrl
DT351_RS05095	COG1792	Involved in formation and maintenance of cell shape
DT351_RS05110	COG2894	cell division
DT351_RS05115	COG0765	amino acid transport
DT351_RS05120	COG1126	abc transporter atp-binding protein
DT351_RS05130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DT351_RS05145	COG3103	Sh3 type 3 domain protein
DT351_RS05145	COG4991	sh3 domain protein
DT351_RS05145	COG0860	N-Acetylmuramoyl-L-alanine amidase
DT351_RS05150	COG0124	histidyl-tRNA synthetase
DT351_RS05160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DT351_RS05165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DT351_RS05170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DT351_RS05185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DT351_RS05190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DT351_RS05195	COG1610	YqeY-like protein
DT351_RS05200	COG1702	phosphate starvation-inducible protein PhoH
DT351_RS05205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DT351_RS05220	COG1381	Involved in DNA repair and RecF pathway recombination
DT351_RS05225	COG0752	glycyl-tRNA synthetase alpha subunit
DT351_RS05230	COG0751	glycine-tRNA ligase activity
DT351_RS05235	COG3189	MarR family transcriptional regulator
DT351_RS05240	COG0358	DNA primase activity
DT351_RS05245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DT351_RS05255	COG2384	SAM-dependent methyltransferase
DT351_RS05260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DT351_RS05265	COG2195	Cleaves the N-terminal amino acid of tripeptides
DT351_RS05270	COG0710	3-dehydroquinate dehydratase activity
DT351_RS05290	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS05310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DT351_RS05315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DT351_RS05320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DT351_RS05360	COG1942	4-Oxalocrotonate Tautomerase
DT351_RS05365	COG0561	phosphatase activity
DT351_RS05370	COG2151	metal-sulfur cluster biosynthetic enzyme
DT351_RS05390	COG1476	TRANSCRIPTIONal
DT351_RS05395	COG1733	regulation of RNA biosynthetic process
DT351_RS05400	COG0604	alcohol dehydrogenase
DT351_RS05405	COG1304	FMN binding
DT351_RS05420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DT351_RS05425	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DT351_RS05430	COG1074	ATP-dependent DNA helicase activity
DT351_RS05435	COG1199	ATP-dependent helicase activity
DT351_RS05435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DT351_RS05445	COG0017	Asparaginyl-tRNA synthetase
DT351_RS05455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DT351_RS05460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DT351_RS05465	COG3331	DNA recombination
DT351_RS05470	COG4474	Belongs to the UPF0398 family
DT351_RS05475	COG3599	regulation of cell shape
DT351_RS05485	COG0116	Belongs to the methyltransferase superfamily
DT351_RS05500	COG0582	viral genome integration into host DNA
DT351_RS05520	COG2186	Transcriptional regulator
DT351_RS05525	COG1131	(ABC) transporter
DT351_RS05550	COG0095	Lipoate-protein ligase
DT351_RS05555	COG3655	Transcriptional regulator
DT351_RS05590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DT351_RS05600	COG1393	Belongs to the ArsC family
DT351_RS05605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DT351_RS05610	COG0328	RNA-DNA hybrid ribonuclease activity
DT351_RS05630	COG1278	Cold shock
DT351_RS05635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DT351_RS05640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DT351_RS05645	COG0564	pseudouridine synthase activity
DT351_RS05650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DT351_RS05655	COG2233	PERMEase
DT351_RS05660	COG0540	Belongs to the ATCase OTCase family
DT351_RS05665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DT351_RS05670	COG0505	Belongs to the CarA family
DT351_RS05675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DT351_RS05680	COG0543	2 iron, 2 sulfur cluster binding
DT351_RS05685	COG0167	dihydroorotate dehydrogenase activity
DT351_RS05690	COG0284	orotidine-5'-phosphate decarboxylase activity
DT351_RS05700	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DT351_RS05710	COG1307	EDD domain protein, DegV family
DT351_RS05720	COG1272	protein, Hemolysin III
DT351_RS05725	COG1307	EDD domain protein, DegV family
DT351_RS05730	COG1309	transcriptional regulator
DT351_RS05735	COG0604	alcohol dehydrogenase
DT351_RS05745	COG4974	Belongs to the 'phage' integrase family
DT351_RS05765	COG1227	inorganic diphosphatase activity
DT351_RS05775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DT351_RS05785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DT351_RS05800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DT351_RS05805	COG0390	transport system, permease component
DT351_RS05810	COG4619	ABC transporter
DT351_RS05815	COG0351	phosphomethylpyrimidine kinase
DT351_RS05820	COG3527	Alpha-acetolactate decarboxylase
DT351_RS05825	COG0028	Belongs to the TPP enzyme family
DT351_RS05835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DT351_RS05850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DT351_RS05855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DT351_RS05860	COG1959	2 iron, 2 sulfur cluster binding
DT351_RS05865	COG0702	epimerase
DT351_RS05870	COG0758	DNA mediated transformation
DT351_RS05875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DT351_RS05890	COG4479	Belongs to the UPF0346 family
DT351_RS05900	COG2755	lipolytic protein G-D-S-L family
DT351_RS05905	COG1307	EDD domain protein, DegV family
DT351_RS05915	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DT351_RS05920	COG0488	(ABC) transporter
DT351_RS05940	COG0617	tRNA 3'-terminal CCA addition
DT351_RS05945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DT351_RS05950	COG2814	Major facilitator Superfamily
DT351_RS05960	COG0457	Tetratricopeptide repeat
DT351_RS05970	COG1160	GTP binding
DT351_RS05975	COG0539	negative regulation of cytoplasmic translation
DT351_RS05980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DT351_RS05990	COG0514	ATP-dependent DNA helicase (RecQ)
DT351_RS06000	COG1141	Ferredoxin
DT351_RS06005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DT351_RS06010	COG1187	pseudouridine synthase activity
DT351_RS06015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DT351_RS06020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DT351_RS06035	COG0735	belongs to the Fur family
DT351_RS06040	COG2996	Protein conserved in bacteria
DT351_RS06045	COG2707	UPF0756 membrane protein
DT351_RS06060	COG0587	DNA-directed DNA polymerase activity
DT351_RS06080	COG0531	amino acid
DT351_RS06090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DT351_RS06095	COG0542	response to heat
DT351_RS06100	COG5416	Lipopolysaccharide assembly protein A domain
DT351_RS06105	COG0300	oxidoreductase activity
DT351_RS06110	COG1234	tRNA 3'-trailer cleavage
DT351_RS06120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DT351_RS06130	COG1349	DNA-binding transcription factor activity
DT351_RS06135	COG1105	Belongs to the carbohydrate kinase PfkB family
DT351_RS06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DT351_RS06140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DT351_RS06140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DT351_RS06145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DT351_RS06155	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS06165	COG1846	Transcriptional regulator
DT351_RS06175	COG0322	excinuclease ABC activity
DT351_RS06185	COG0765	amino acid transport
DT351_RS06195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DT351_RS06200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DT351_RS06205	COG0544	peptidyl-prolyl cis-trans isomerase activity
DT351_RS06210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DT351_RS06225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DT351_RS06230	COG0268	Binds directly to 16S ribosomal RNA
DT351_RS06235	COG1466	dna polymerase III delta subunit
DT351_RS06240	COG2333	competence protein COMEC
DT351_RS06240	COG0658	competence protein
DT351_RS06245	COG2131	deaminase
DT351_RS06250	COG1596	polysaccharide export
DT351_RS06250	COG1555	photosystem II stabilization
DT351_RS06255	COG3480	Lon protease (S16) C-terminal proteolytic domain
DT351_RS06260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DT351_RS06265	COG0742	ribosomal rna small subunit methyltransferase
DT351_RS06270	COG4471	UPF0298 protein
DT351_RS06280	COG0772	Belongs to the SEDS family
DT351_RS06285	COG4838	Belongs to the UPF0358 family
DT351_RS06290	COG1217	gtp-binding protein TYPA
DT351_RS06295	COG0483	inositol monophosphate 1-phosphatase activity
DT351_RS06300	COG4476	Belongs to the UPF0223 family
DT351_RS06330	COG0242	peptide deformylase activity
DT351_RS06355	COG5503	Protein of unknown function (DUF1447)
DT351_RS06365	COG1597	lipid kinase activity
DT351_RS06375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DT351_RS06390	COG0446	pyridine nucleotide-disulphide oxidoreductase
DT351_RS06395	COG0482	sulfurtransferase activity
DT351_RS06405	COG1104	cysteine desulfurase activity
DT351_RS06410	COG1606	tRNA processing
DT351_RS06420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DT351_RS06425	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DT351_RS06430	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DT351_RS06435	COG1691	(AIR) carboxylase
DT351_RS06440	COG3875	lactate racemase activity
DT351_RS06445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DT351_RS06450	COG0310	cobalt ion transport
DT351_RS06455	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DT351_RS06460	COG1122	ATPase activity
DT351_RS06465	COG1619	proteins homologs of microcin C7 resistance protein MccF
DT351_RS06480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DT351_RS06490	COG0494	nUDIX hydrolase
DT351_RS06500	COG3853	Toxic anion resistance protein (TelA)
DT351_RS06505	COG2814	Major facilitator Superfamily
DT351_RS06510	COG1757	Na H antiporter
DT351_RS06540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DT351_RS06560	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DT351_RS06565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DT351_RS06575	COG1609	Transcriptional regulator
DT351_RS06600	COG3684	Belongs to the aldolase LacD family
DT351_RS06605	COG0698	ribose 5-phosphate isomerase
DT351_RS06610	COG0698	ribose 5-phosphate isomerase
DT351_RS06615	COG1349	DNA-binding transcription factor activity
DT351_RS06645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DT351_RS06650	COG3599	regulation of cell shape
DT351_RS06655	COG2302	S4 RNA-binding domain
DT351_RS06665	COG1799	cell septum assembly
DT351_RS06685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DT351_RS06690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DT351_RS06695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DT351_RS06700	COG0768	penicillin binding
DT351_RS06710	COG0275	rRNA processing
DT351_RS06715	COG2001	Belongs to the MraZ family
DT351_RS06735	COG1490	D-aminoacyl-tRNA deacylase activity
DT351_RS06740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DT351_RS06750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DT351_RS06755	COG2264	protein methyltransferase activity
DT351_RS06770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DT351_RS06795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DT351_RS06800	COG1518	maintenance of DNA repeat elements
DT351_RS06815	COG1857	crispr-associated protein
DT351_RS06865	COG0335	large ribosomal subunit rRNA binding
DT351_RS06870	COG0336	Belongs to the RNA methyltransferase TrmD family
DT351_RS06875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DT351_RS06880	COG1837	Belongs to the UPF0109 family
DT351_RS06885	COG0228	four-way junction DNA binding
DT351_RS06890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DT351_RS06895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DT351_RS06905	COG2801	Transposase and inactivated derivatives
DT351_RS06915	COG1929	Belongs to the glycerate kinase type-1 family
DT351_RS06920	COG0552	protein localization to endoplasmic reticulum
DT351_RS06925	COG1196	nuclear chromosome segregation
DT351_RS06930	COG0571	ribonuclease III activity
DT351_RS06935	COG4608	Belongs to the ABC transporter superfamily
DT351_RS06940	COG0444	Belongs to the ABC transporter superfamily
DT351_RS06945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DT351_RS06950	COG0601	transmembrane transport
DT351_RS06955	COG4166	transmembrane transport
DT351_RS06960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DT351_RS06965	COG0416	fatty acid biosynthetic process
DT351_RS06970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DT351_RS06975	COG1461	Dihydroxyacetone kinase
DT351_RS06980	COG1302	Protein conserved in bacteria
DT351_RS06985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DT351_RS06990	COG1564	THIamine pyrophosphokinase
DT351_RS06995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DT351_RS07000	COG1162	GTPase activity
DT351_RS07005	COG2815	serine threonine protein kinase
DT351_RS07005	COG0515	serine threonine protein kinase
DT351_RS07015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DT351_RS07015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DT351_RS07020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DT351_RS07025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DT351_RS07030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DT351_RS07035	COG1758	RNA polymerase activity
DT351_RS07040	COG0194	GDP metabolic process
DT351_RS07055	COG0497	DNA recombination
DT351_RS07060	COG1438	arginine binding
DT351_RS07065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DT351_RS07075	COG1722	exodeoxyribonuclease VII activity
DT351_RS07080	COG1570	exodeoxyribonuclease VII activity
DT351_RS07085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DT351_RS07090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DT351_RS07095	COG1302	Protein conserved in bacteria
DT351_RS07100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DT351_RS07105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DT351_RS07115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DT351_RS07135	COG0151	Belongs to the GarS family
DT351_RS07140	COG0138	bifunctional purine biosynthesis protein purh
DT351_RS07145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DT351_RS07150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DT351_RS07155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DT351_RS07160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DT351_RS07165	COG0047	phosphoribosylformylglycinamidine synthase activity
DT351_RS07170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DT351_RS07175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DT351_RS07180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DT351_RS07185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DT351_RS07195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DT351_RS07200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DT351_RS07205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DT351_RS07210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DT351_RS07225	COG1278	Cold shock
DT351_RS07230	COG1694	Mazg nucleotide pyrophosphohydrolase
DT351_RS07405	COG0629	single-stranded DNA binding
DT351_RS07490	COG1396	sequence-specific DNA binding
DT351_RS07500	COG2176	DNA-directed DNA polymerase activity
DT351_RS07520	COG2936	dipeptidyl-peptidase activity
DT351_RS07525	COG1607	acyl-coa hydrolase
DT351_RS07540	COG0670	Belongs to the BI1 family
DT351_RS07545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DT351_RS07550	COG0367	asparagine synthase
DT351_RS07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT351_RS07560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DT351_RS07570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DT351_RS07575	COG0510	thiamine kinase activity
DT351_RS07580	COG4473	ABC transporter
DT351_RS07585	COG1131	(ABC) transporter
DT351_RS07590	COG0537	adenosine 5'-monophosphoramidase activity
DT351_RS07600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DT351_RS07605	COG3481	metal-dependent phosphohydrolase, HD sub domain
DT351_RS07610	COG4717	serine-type aminopeptidase activity
DT351_RS07615	COG0420	3'-5' exonuclease activity
DT351_RS07620	COG3679	Belongs to the UPF0342 family
DT351_RS07625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DT351_RS07630	COG0564	pseudouridine synthase activity
DT351_RS07635	COG1438	arginine binding
DT351_RS07640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DT351_RS07640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DT351_RS07640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DT351_RS07650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DT351_RS07650	COG3711	transcriptional antiterminator
DT351_RS07690	COG0346	lactoylglutathione lyase activity
DT351_RS07705	COG0148	phosphopyruvate hydratase activity
DT351_RS07710	COG0149	triose-phosphate isomerase activity
DT351_RS07715	COG0126	phosphoglycerate kinase activity
DT351_RS07725	COG2390	Transcriptional regulator
DT351_RS07790	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS07810	COG0584	glycerophosphoryl diester phosphodiesterase
DT351_RS07820	COG0446	pyridine nucleotide-disulphide oxidoreductase
DT351_RS07870	COG2274	protein secretion by the type I secretion system
DT351_RS07895	COG3279	Response regulator of the LytR AlgR family
DT351_RS07935	COG1764	response to oxidative stress
DT351_RS07940	COG4166	transmembrane transport
DT351_RS07950	COG2197	response regulator
DT351_RS07955	COG4585	Histidine kinase
DT351_RS07965	COG1131	(ABC) transporter
DT351_RS07970	COG2094	Belongs to the DNA glycosylase MPG family
DT351_RS08020	COG1957	nucleoside hydrolase
DT351_RS08040	COG0740	serine-type endopeptidase activity
DT351_RS08055	COG1481	regulation of sporulation
DT351_RS08060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DT351_RS08065	COG1660	Displays ATPase and GTPase activities
DT351_RS08075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DT351_RS08080	COG0556	nucleotide-excision repair
DT351_RS08090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DT351_RS08095	COG0492	ferredoxin-NADP+ reductase activity
DT351_RS08105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DT351_RS08110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DT351_RS08115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DT351_RS08120	COG1950	PFAM Membrane protein of
DT351_RS08130	COG1983	PspC domain protein
DT351_RS08155	COG0704	Plays a role in the regulation of phosphate uptake
DT351_RS08160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DT351_RS08165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DT351_RS08170	COG0581	inorganic phosphate transmembrane transporter activity
DT351_RS08175	COG0573	inorganic phosphate transmembrane transporter activity
DT351_RS08185	COG5002	protein histidine kinase activity
DT351_RS08190	COG0745	RESPONSE REGULATOR receiver
DT351_RS08205	COG2177	Part of the ABC transporter FtsEX involved in
DT351_RS08210	COG2884	Cell division ATP-binding protein ftsE
DT351_RS08220	COG0653	protein targeting
DT351_RS08230	COG1040	competence protein
DT351_RS08235	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DT351_RS08240	COG1739	Uncharacterized protein family UPF0029
DT351_RS08245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DT351_RS08255	COG1418	mRNA catabolic process
DT351_RS08260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DT351_RS08265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DT351_RS08270	COG1426	Protein conserved in bacteria
DT351_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
DT351_RS08280	COG0612	Peptidase, M16
DT351_RS08285	COG0612	Peptidase, M16
DT351_RS08300	COG1674	ftsk spoiiie
DT351_RS08315	COG2226	methyltransferase
DT351_RS08325	COG0516	GMP reductase activity
DT351_RS08330	COG2153	protein acetylation
DT351_RS08335	COG0628	permease
DT351_RS08345	COG2706	6-phosphogluconolactonase activity
DT351_RS08350	COG0477	Major facilitator Superfamily
DT351_RS08355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DT351_RS08405	COG0735	belongs to the Fur family
DT351_RS08410	COG1368	sulfuric ester hydrolase activity
DT351_RS08420	COG2084	Dehydrogenase
DT351_RS08430	COG0438	transferase activity, transferring glycosyl groups
DT351_RS08445	COG0730	response to heat
DT351_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
DT351_RS08475	COG3716	PTS system mannose fructose sorbose family IID component
DT351_RS08480	COG3715	PTS system
DT351_RS08495	COG1011	Hydrolase
DT351_RS08500	COG0167	dihydroorotate dehydrogenase activity
DT351_RS08530	COG0251	oxidation-reduction process
DT351_RS08540	COG0281	malic enzyme
DT351_RS08545	COG0583	DNA-binding transcription factor activity
DT351_RS08730	COG1098	S1 RNA binding domain
DT351_RS08735	COG1940	carbohydrate kinase activity
DT351_RS08740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DT351_RS08745	COG0492	ferredoxin-NADP+ reductase activity
DT351_RS08750	COG0586	Pfam SNARE associated Golgi protein
DT351_RS08760	COG0647	UMP catabolic process
DT351_RS08765	COG4470	Protein conserved in bacteria
DT351_RS08770	COG0737	Belongs to the 5'-nucleotidase family
DT351_RS08790	COG0640	Transcriptional regulator
DT351_RS08795	COG2217	Heavy metal translocating P-type atpase
DT351_RS08810	COG2814	Major facilitator Superfamily
DT351_RS08825	COG0363	glucosamine-6-phosphate deaminase activity
DT351_RS08830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DT351_RS08835	COG1609	Transcriptional regulator
DT351_RS08840	COG0006	proline dipeptidase activity
DT351_RS08865	COG0668	transmembrane transport
DT351_RS08875	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS08890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DT351_RS08895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DT351_RS08900	COG1719	4-vinyl reductase, 4VR
DT351_RS08905	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DT351_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DT351_RS08915	COG1696	Membrane protein involved in D-alanine export
DT351_RS08920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DT351_RS08930	COG3118	belongs to the thioredoxin family
DT351_RS08935	COG1193	negative regulation of DNA recombination
DT351_RS08940	COG1286	toxin biosynthetic process
DT351_RS08945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DT351_RS08950	COG3906	Belongs to the UPF0473 family
DT351_RS08955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DT351_RS08960	COG4472	Bacterial protein of unknown function (DUF965)
DT351_RS08965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DT351_RS08975	COG0513	Belongs to the DEAD box helicase family
DT351_RS08980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DT351_RS08985	COG4109	DRTGG domain
DT351_RS08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT351_RS08995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DT351_RS09000	COG1321	iron dependent repressor
DT351_RS09005	COG1454	alcohol dehydrogenase
DT351_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
DT351_RS09010	COG1862	Preprotein translocase
DT351_RS09015	COG0343	queuine tRNA-ribosyltransferase activity
DT351_RS09025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DT351_RS09030	COG2255	four-way junction helicase activity
DT351_RS09035	COG0632	four-way junction helicase activity
DT351_RS09045	COG0424	maF-like protein
DT351_RS09055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DT351_RS09060	COG1692	metallophosphoesterase
DT351_RS09065	COG0531	amino acid
DT351_RS09080	COG0459	protein refolding
DT351_RS09085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DT351_RS09090	COG1266	CAAX protease self-immunity
DT351_RS09100	COG0488	(ABC) transporter
DT351_RS09110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS09120	COG3688	RNA-binding protein containing a PIN domain
DT351_RS09125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DT351_RS09130	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DT351_RS09135	COG0215	cysteine-tRNA ligase activity
DT351_RS09140	COG4956	integral membrane protein (PIN domain superfamily)
DT351_RS09145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DT351_RS09150	COG0756	dUTP diphosphatase activity
DT351_RS09170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DT351_RS09175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS09185	COG2188	Transcriptional regulator
DT351_RS09190	COG1446	asparaginase
DT351_RS09225	COG0402	S-adenosylhomocysteine deaminase activity
DT351_RS09235	COG1285	pathogenesis
DT351_RS09240	COG1914	H( )-stimulated, divalent metal cation uptake system
DT351_RS09250	COG1070	Carbohydrate kinase
DT351_RS09255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DT351_RS09260	COG1737	Transcriptional regulator
DT351_RS09265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DT351_RS09270	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DT351_RS09275	COG2188	Transcriptional regulator
DT351_RS09295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DT351_RS09305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DT351_RS09310	COG1316	TRANSCRIPTIONal
DT351_RS09325	COG1121	(ABC) transporter
DT351_RS09340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DT351_RS09345	COG1686	Belongs to the peptidase S11 family
DT351_RS09350	COG5002	protein histidine kinase activity
DT351_RS09360	COG0516	GMP reductase activity
DT351_RS09360	COG0517	IMP dehydrogenase activity
DT351_RS09365	COG2365	Tyrosine phosphatase family
DT351_RS09370	COG1079	Belongs to the binding-protein-dependent transport system permease family
DT351_RS09375	COG4603	Belongs to the binding-protein-dependent transport system permease family
DT351_RS09380	COG3845	ABC transporter
DT351_RS09385	COG1744	ABC transporter substrate-binding protein PnrA-like
DT351_RS09395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DT351_RS09400	COG1695	Transcriptional regulator
DT351_RS09405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DT351_RS09425	COG1957	nucleoside hydrolase
DT351_RS09435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DT351_RS09460	COG1914	H( )-stimulated, divalent metal cation uptake system
DT351_RS09535	COG1215	transferase activity, transferring glycosyl groups
DT351_RS09585	COG0561	phosphatase activity
DT351_RS09590	COG0308	aminopeptidase N
DT351_RS09600	COG2801	Transposase and inactivated derivatives
DT351_RS09610	COG4221	oxidoreductase activity
DT351_RS09620	COG0583	DNA-binding transcription factor activity
DT351_RS09640	COG3716	PTS system mannose fructose sorbose family IID component
DT351_RS09645	COG3715	PTS system
DT351_RS09650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DT351_RS09655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DT351_RS09660	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DT351_RS09660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DT351_RS09670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DT351_RS09680	COG1940	carbohydrate kinase activity
DT351_RS09715	COG3118	belongs to the thioredoxin family
DT351_RS09720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DT351_RS09755	COG4221	oxidoreductase activity
DT351_RS09775	COG0588	phosphoglycerate mutase activity
DT351_RS09780	COG0477	Major facilitator Superfamily
DT351_RS09795	COG1879	ABC-type sugar transport system periplasmic component
DT351_RS09800	COG1172	Belongs to the binding-protein-dependent transport system permease family
DT351_RS09815	COG1609	Transcriptional regulator
DT351_RS09825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DT351_RS09960	COG0531	amino acid
DT351_RS09965	COG0488	(ABC) transporter
DT351_RS09970	COG1316	TRANSCRIPTIONal
DT351_RS09975	COG1316	TRANSCRIPTIONal
DT351_RS09985	COG2211	Major facilitator Superfamily
DT351_RS09985	COG2190	(PTS) system
DT351_RS10020	COG3876	Protein conserved in bacteria
DT351_RS10025	COG1254	Belongs to the acylphosphatase family
DT351_RS10030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DT351_RS10035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DT351_RS10050	COG4690	dipeptidase activity
DT351_RS10070	COG1302	Protein conserved in bacteria
DT351_RS10085	COG2261	transglycosylase associated protein
DT351_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
DT351_RS10105	COG1442	glycosyl transferase family 8
DT351_RS10115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DT351_RS10120	COG1121	(ABC) transporter
DT351_RS10125	COG0383	alpha-mannosidase activity
DT351_RS10130	COG0383	alpha-mannosidase activity
DT351_RS10140	COG2124	cytochrome p450
DT351_RS10215	COG0519	Catalyzes the synthesis of GMP from XMP
DT351_RS10220	COG1072	(Pantothenic acid kinase))
DT351_RS10230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DT351_RS10255	COG0783	Belongs to the Dps family
DT351_RS10285	COG5617	Psort location CytoplasmicMembrane, score
DT351_RS10290	COG2826	transposase and inactivated derivatives, IS30 family
DT351_RS10295	COG3973	AAA domain
DT351_RS10300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DT351_RS10305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DT351_RS10315	COG2267	carboxylic ester hydrolase activity
DT351_RS10335	COG1136	(ABC) transporter
DT351_RS10340	COG0531	amino acid
DT351_RS10345	COG0366	Alpha amylase catalytic
DT351_RS10350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DT351_RS10360	COG3842	ATPase activity
DT351_RS10385	COG1609	Transcriptional regulator
DT351_RS10405	COG0531	amino acid
DT351_RS10410	COG1940	carbohydrate kinase activity
DT351_RS10415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DT351_RS10475	COG0735	belongs to the Fur family
DT351_RS10485	COG0194	GDP metabolic process
DT351_RS10500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DT351_RS10520	COG0588	phosphoglycerate mutase activity
DT351_RS10525	COG0681	Belongs to the peptidase S26 family
DT351_RS10530	COG1288	antiporter activity
DT351_RS10535	COG2814	Major facilitator Superfamily
DT351_RS10550	COG0697	spore germination
DT351_RS10570	COG0488	(ABC) transporter
DT351_RS10575	COG0445	tRNA wobble uridine modification
DT351_RS10580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DT351_RS10600	COG0706	membrane insertase activity
DT351_RS10605	COG0594	ribonuclease P activity
DT351_RS10610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DT351_RS10615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DT351_RS10625	COG0662	Cupin 2, conserved barrel domain protein
DT351_RS10655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT351_RS10675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DT351_RS10680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DT351_RS10685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DT351_RS10710	COG1960	acyl-CoA dehydrogenase activity
DT351_RS10715	COG2086	electron transfer activity
DT351_RS10720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DT351_RS10730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DT351_RS10760	COG1002	Type II restriction enzyme, methylase subunits
DT351_RS10850	COG4876	unkown
DT351_RS10860	COG1136	(ABC) transporter
DT351_RS10865	COG0577	efflux transmembrane transporter activity
DT351_RS10910	COG1192	Involved in chromosome partitioning
DT351_RS10915	COG2814	Major facilitator Superfamily
DT351_RS11080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT351_RS11110	COG4974	Belongs to the 'phage' integrase family
DT351_RS11120	COG1192	Involved in chromosome partitioning
DT351_RS11130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DT351_RS11300	COG1132	(ABC) transporter