locus-tag	class	description
BC336_RS00015	COG0592	DNA-directed DNA polymerase activity
BC336_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC336_RS00030	COG0187	DNA topoisomerase II activity
BC336_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC336_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
BC336_RS00045	COG0629	single-stranded DNA binding
BC336_RS00060	COG0359	binds to the 23S rRNA
BC336_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
BC336_RS00075	COG1136	(ABC) transporter
BC336_RS00090	COG1285	pathogenesis
BC336_RS00115	COG4619	ABC transporter
BC336_RS00120	COG0390	transport system, permease component
BC336_RS00175	COG1942	4-Oxalocrotonate Tautomerase
BC336_RS00210	COG1482	cell wall glycoprotein biosynthetic process
BC336_RS00245	COG1191	sigma factor activity
BC336_RS00250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BC336_RS00265	COG0463	Glycosyl transferase, family 2
BC336_RS00275	COG1307	EDD domain protein, DegV family
BC336_RS00290	COG0588	phosphoglycerate mutase activity
BC336_RS00320	COG1268	BioY protein
BC336_RS00330	COG1011	Hydrolase
BC336_RS00345	COG0708	Exodeoxyribonuclease III
BC336_RS00360	COG0656	L-ascorbic acid biosynthetic process
BC336_RS00365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC336_RS00380	COG2096	Adenosyltransferase
BC336_RS00390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC336_RS00400	COG0242	peptide deformylase activity
BC336_RS00430	COG1132	(ABC) transporter
BC336_RS00440	COG1193	negative regulation of DNA recombination
BC336_RS00460	COG1940	carbohydrate kinase activity
BC336_RS00470	COG2814	Major facilitator Superfamily
BC336_RS00485	COG0583	DNA-binding transcription factor activity
BC336_RS00525	COG0745	RESPONSE REGULATOR receiver
BC336_RS00530	COG5002	protein histidine kinase activity
BC336_RS00545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC336_RS00550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC336_RS00590	COG1122	ATPase activity
BC336_RS00595	COG0477	Major facilitator Superfamily
BC336_RS00605	COG4555	ABC transporter
BC336_RS00630	COG0501	Belongs to the peptidase M48B family
BC336_RS00635	COG1704	LemA family
BC336_RS00640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC336_RS00665	COG1126	abc transporter atp-binding protein
BC336_RS00670	COG0765	amino acid transport
BC336_RS00675	COG2094	Belongs to the DNA glycosylase MPG family
BC336_RS00680	COG3189	MarR family transcriptional regulator
BC336_RS00685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BC336_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC336_RS00705	COG0328	RNA-DNA hybrid ribonuclease activity
BC336_RS00715	COG1216	Glycosyl transferase, family 2
BC336_RS00720	COG2267	carboxylic ester hydrolase activity
BC336_RS00725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC336_RS00740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC336_RS00770	COG0657	acetylesterase activity
BC336_RS00770	COG2755	lipolytic protein G-D-S-L family
BC336_RS00795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC336_RS00810	COG2365	Tyrosine phosphatase family
BC336_RS00815	COG0589	response to stress
BC336_RS00825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC336_RS00830	COG3639	organic phosphonate transmembrane transporter activity
BC336_RS00840	COG4166	transmembrane transport
BC336_RS00855	COG0367	asparagine synthase
BC336_RS00870	COG0602	queuosine metabolic process
BC336_RS00885	COG2814	Major facilitator Superfamily
BC336_RS00890	COG4545	Glutaredoxin-related protein
BC336_RS00895	COG3590	peptidase
BC336_RS00930	COG1705	Flagellar rod assembly protein muramidase FlgJ
BC336_RS00930	COG1388	LysM domain
BC336_RS00940	COG0569	domain protein
BC336_RS00940	COG0475	glutathione-regulated potassium exporter activity
BC336_RS00955	COG0588	phosphoglycerate mutase activity
BC336_RS00960	COG1316	TRANSCRIPTIONal
BC336_RS00965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC336_RS00970	COG1368	sulfuric ester hydrolase activity
BC336_RS00990	COG1051	belongs to the nudix hydrolase family
BC336_RS01010	COG0765	amino acid transport
BC336_RS01015	COG0765	amino acid transport
BC336_RS01020	COG1126	abc transporter atp-binding protein
BC336_RS01060	COG1473	amidohydrolase
BC336_RS01085	COG1418	mRNA catabolic process
BC336_RS01095	COG4166	transmembrane transport
BC336_RS01105	COG4166	transmembrane transport
BC336_RS01110	COG0601	transmembrane transport
BC336_RS01115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC336_RS01120	COG0444	Belongs to the ABC transporter superfamily
BC336_RS01125	COG4608	Belongs to the ABC transporter superfamily
BC336_RS01150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC336_RS01155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BC336_RS01165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC336_RS01185	COG0516	GMP reductase activity
BC336_RS01185	COG0517	IMP dehydrogenase activity
BC336_RS01210	COG1132	(ABC) transporter
BC336_RS01245	COG0833	amino acid
BC336_RS01250	COG2040	homocysteine
BC336_RS01270	COG0252	asparaginase activity
BC336_RS01285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BC336_RS01295	COG1335	isochorismatase
BC336_RS01340	COG1121	(ABC) transporter
BC336_RS01375	COG2131	deaminase
BC336_RS01385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC336_RS01390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC336_RS01390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC336_RS01395	COG0084	hydrolase, TatD family'
BC336_RS01415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC336_RS01430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC336_RS01435	COG1078	dGTPase activity
BC336_RS01445	COG3343	RNA polymerase activity
BC336_RS01450	COG0504	CTP synthase activity
BC336_RS01455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC336_RS01465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC336_RS01480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC336_RS01495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC336_RS01500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BC336_RS01525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC336_RS01535	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC336_RS01540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC336_RS01545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BC336_RS01555	COG2199	diguanylate cyclase activity
BC336_RS01595	COG1956	GAF domain-containing protein
BC336_RS01600	COG0542	response to heat
BC336_RS01645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC336_RS01710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC336_RS01760	COG0563	adenylate kinase activity
BC336_RS01765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC336_RS01785	COG0202	RNA polymerase activity
BC336_RS01805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC336_RS01815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC336_RS01820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BC336_RS01845	COG1051	belongs to the nudix hydrolase family
BC336_RS01855	COG1881	PFAM PEBP family protein
BC336_RS01900	COG2188	Transcriptional regulator
BC336_RS01905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BC336_RS01950	COG1131	(ABC) transporter
BC336_RS01955	COG3091	SprT-like family
BC336_RS01970	COG1705	Flagellar rod assembly protein muramidase FlgJ
BC336_RS01985	COG4851	CamS sex pheromone cAM373 precursor
BC336_RS02005	COG1597	lipid kinase activity
BC336_RS02015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC336_RS02050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC336_RS02090	COG3759	membrane
BC336_RS02095	COG1522	sequence-specific DNA binding
BC336_RS02100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC336_RS02115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BC336_RS02125	COG0488	(ABC) transporter
BC336_RS02165	COG0670	Belongs to the BI1 family
BC336_RS02175	COG4690	dipeptidase activity
BC336_RS02190	COG0572	uridine kinase
BC336_RS02195	COG0572	uridine kinase
BC336_RS02205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC336_RS02210	COG0765	amino acid transport
BC336_RS02215	COG0765	amino acid transport
BC336_RS02220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC336_RS02230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BC336_RS02265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC336_RS02280	COG2188	Transcriptional regulator
BC336_RS02305	COG1253	flavin adenine dinucleotide binding
BC336_RS02315	COG0531	amino acid
BC336_RS02330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC336_RS02375	COG0531	amino acid
BC336_RS02385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC336_RS02395	COG0716	FMN binding
BC336_RS02400	COG0024	Methionine aminopeptidase
BC336_RS02405	COG1295	ribonuclease BN
BC336_RS02410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC336_RS02425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC336_RS02470	COG0542	response to heat
BC336_RS02480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC336_RS02490	COG1393	Belongs to the ArsC family
BC336_RS02495	COG4862	establishment of competence for transformation
BC336_RS02520	COG2357	RelA SpoT domain protein
BC336_RS02530	COG0564	pseudouridine synthase activity
BC336_RS02545	COG2706	6-phosphogluconolactonase activity
BC336_RS02555	COG0628	permease
BC336_RS02570	COG1674	ftsk spoiiie
BC336_RS02570	COG1280	lysine exporter protein (LysE YggA)
BC336_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
BC336_RS02590	COG1426	Protein conserved in bacteria
BC336_RS02595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC336_RS02610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC336_RS02615	COG1739	Uncharacterized protein family UPF0029
BC336_RS02620	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BC336_RS02635	COG0653	protein targeting
BC336_RS02650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BC336_RS02660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BC336_RS02665	COG0492	ferredoxin-NADP+ reductase activity
BC336_RS02670	COG0556	nucleotide-excision repair
BC336_RS02675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC336_RS02705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BC336_RS02710	COG1481	regulation of sporulation
BC336_RS02780	COG0561	phosphatase activity
BC336_RS02785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC336_RS02790	COG0280	phosphate acetyltransferase
BC336_RS02795	COG0802	atpase or kinase
BC336_RS02810	COG3842	ATPase activity
BC336_RS02820	COG1177	transmembrane transport
BC336_RS02865	COG2217	Heavy metal translocating P-type atpase
BC336_RS02870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC336_RS02875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC336_RS02890	COG2199	diguanylate cyclase activity
BC336_RS02890	COG2200	EAL domain
BC336_RS02910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC336_RS02920	COG0531	amino acid
BC336_RS02935	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC336_RS02950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC336_RS02955	COG1459	type II secretion system
BC336_RS02980	COG0827	DNA restriction-modification system
BC336_RS02995	COG0745	RESPONSE REGULATOR receiver
BC336_RS03000	COG3850	Histidine kinase
BC336_RS03000	COG5002	protein histidine kinase activity
BC336_RS03005	COG1368	sulfuric ester hydrolase activity
BC336_RS03015	COG0166	Belongs to the GPI family
BC336_RS03035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC336_RS03045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC336_RS03050	COG1435	thymidine kinase activity
BC336_RS03060	COG2890	protein-(glutamine-N5) methyltransferase activity
BC336_RS03065	COG0009	L-threonylcarbamoyladenylate synthase
BC336_RS03075	COG0356	it plays a direct role in the translocation of protons across the membrane
BC336_RS03080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC336_RS03095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC336_RS03120	COG1077	Cell shape determining protein MreB Mrl
BC336_RS03125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC336_RS03135	COG0772	Belongs to the SEDS family
BC336_RS03150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC336_RS03165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BC336_RS03170	COG1104	cysteine desulfurase activity
BC336_RS03180	COG1187	pseudouridine synthase activity
BC336_RS03185	COG0525	valine-tRNA ligase activity
BC336_RS03195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC336_RS03200	COG2003	Belongs to the UPF0758 family
BC336_RS03205	COG1077	Cell shape determining protein MreB Mrl
BC336_RS03210	COG1792	Involved in formation and maintenance of cell shape
BC336_RS03245	COG0768	penicillin binding
BC336_RS03265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC336_RS03270	COG0849	cell division
BC336_RS03275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BC336_RS03300	COG1278	Cold shock
BC336_RS03315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC336_RS03320	COG1104	cysteine desulfurase activity
BC336_RS03335	COG0406	alpha-ribazole phosphatase activity
BC336_RS03345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC336_RS03350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC336_RS03365	COG0242	peptide deformylase activity
BC336_RS03370	COG1217	gtp-binding protein TYPA
BC336_RS03385	COG0742	ribosomal rna small subunit methyltransferase
BC336_RS03390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC336_RS03395	COG3480	Lon protease (S16) C-terminal proteolytic domain
BC336_RS03400	COG1555	photosystem II stabilization
BC336_RS03405	COG0658	competence protein
BC336_RS03405	COG2333	competence protein COMEC
BC336_RS03410	COG1466	dna polymerase III delta subunit
BC336_RS03445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC336_RS03465	COG4166	transmembrane transport
BC336_RS03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC336_RS03490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC336_RS03500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC336_RS03510	COG1053	succinate dehydrogenase
BC336_RS03550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC336_RS03555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC336_RS03560	COG0583	DNA-binding transcription factor activity
BC336_RS03575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC336_RS03585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC336_RS03590	COG0514	ATP-dependent DNA helicase (RecQ)
BC336_RS03610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BC336_RS03610	COG2755	lipolytic protein G-D-S-L family
BC336_RS03620	COG0300	oxidoreductase activity
BC336_RS03630	COG0737	Belongs to the 5'-nucleotidase family
BC336_RS03655	COG4475	Protein of unknown function (DUF436)
BC336_RS03665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC336_RS03675	COG0587	DNA-directed DNA polymerase activity
BC336_RS03690	COG1116	anion transmembrane transporter activity
BC336_RS03705	COG2996	Protein conserved in bacteria
BC336_RS03715	COG0456	acetyltransferase
BC336_RS03725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC336_RS03730	COG1187	pseudouridine synthase activity
BC336_RS03735	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BC336_RS03750	COG0539	negative regulation of cytoplasmic translation
BC336_RS03780	COG0583	DNA-binding transcription factor activity
BC336_RS03785	COG0583	DNA-binding transcription factor activity
BC336_RS03825	COG1053	succinate dehydrogenase
BC336_RS03825	COG3976	FMN-binding domain protein
BC336_RS03825	COG0431	NADPH-dependent FMN reductase
BC336_RS03830	COG2357	RelA SpoT domain protein
BC336_RS03835	COG0745	RESPONSE REGULATOR receiver
BC336_RS03840	COG5002	protein histidine kinase activity
BC336_RS03850	COG1518	maintenance of DNA repeat elements
BC336_RS03865	COG0183	Belongs to the thiolase family
BC336_RS03875	COG3425	synthase
BC336_RS03885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC336_RS03890	COG2264	protein methyltransferase activity
BC336_RS03895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC336_RS03900	COG1490	D-aminoacyl-tRNA deacylase activity
BC336_RS03910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC336_RS03940	COG0628	permease
BC336_RS03950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC336_RS03955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BC336_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
BC336_RS03965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC336_RS03980	COG0439	Biotin carboxylase
BC336_RS03990	COG0825	malonyl-CoA metabolic process
BC336_RS03995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BC336_RS04140	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BC336_RS04160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC336_RS04165	COG0573	inorganic phosphate transmembrane transporter activity
BC336_RS04170	COG0581	inorganic phosphate transmembrane transporter activity
BC336_RS04175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC336_RS04180	COG0704	Plays a role in the regulation of phosphate uptake
BC336_RS04190	COG5002	protein histidine kinase activity
BC336_RS04205	COG0488	(ABC) transporter
BC336_RS04230	COG1288	antiporter activity
BC336_RS04240	COG1122	ATPase activity
BC336_RS04245	COG1122	ATPase activity
BC336_RS04280	COG0561	phosphatase activity
BC336_RS04310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC336_RS04315	COG0187	DNA topoisomerase II activity
BC336_RS04320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC336_RS04325	COG1227	inorganic diphosphatase activity
BC336_RS04330	COG1304	FMN binding
BC336_RS04350	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BC336_RS04355	COG1074	ATP-dependent DNA helicase activity
BC336_RS04360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC336_RS04360	COG1199	ATP-dependent helicase activity
BC336_RS04370	COG0017	Asparaginyl-tRNA synthetase
BC336_RS04375	COG3935	DnaD domain protein
BC336_RS04380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC336_RS04385	COG0561	phosphatase activity
BC336_RS04405	COG0823	Involved in the tonB-independent uptake of proteins
BC336_RS04405	COG4946	Tricorn protease homolog
BC336_RS04405	COG1506	peptidase
BC336_RS04410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC336_RS04420	COG4474	Belongs to the UPF0398 family
BC336_RS04425	COG3599	regulation of cell shape
BC336_RS04435	COG0116	Belongs to the methyltransferase superfamily
BC336_RS04450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BC336_RS04460	COG0564	pseudouridine synthase activity
BC336_RS04465	COG0505	Belongs to the CarA family
BC336_RS04470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC336_RS04475	COG3830	Belongs to the UPF0237 family
BC336_RS04485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BC336_RS04490	COG1307	EDD domain protein, DegV family
BC336_RS04510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BC336_RS04515	COG0406	alpha-ribazole phosphatase activity
BC336_RS04545	COG4974	Belongs to the 'phage' integrase family
BC336_RS04550	COG1929	Belongs to the glycerate kinase type-1 family
BC336_RS04600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BC336_RS04605	COG2252	PERMEase
BC336_RS04610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC336_RS04640	COG1132	(ABC) transporter
BC336_RS04655	COG3706	GGDEF domain
BC336_RS04680	COG0582	viral genome integration into host DNA
BC336_RS04705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC336_RS04715	COG1136	(ABC) transporter
BC336_RS04770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC336_RS04790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC336_RS04840	COG1136	(ABC) transporter
BC336_RS04850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC336_RS04875	COG0582	viral genome integration into host DNA
BC336_RS04900	COG3706	GGDEF domain
BC336_RS04915	COG1132	(ABC) transporter
BC336_RS04950	COG1132	(ABC) transporter
BC336_RS04955	COG1132	(ABC) transporter
BC336_RS04965	COG0328	RNA-DNA hybrid ribonuclease activity
BC336_RS04980	COG0328	RNA-DNA hybrid ribonuclease activity
BC336_RS04995	COG0546	phosphoglycolate phosphatase activity
BC336_RS05020	COG2315	Protein conserved in bacteria
BC336_RS05025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BC336_RS05085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC336_RS05120	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC336_RS05125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC336_RS05125	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BC336_RS05150	COG2339	peptidase activity
BC336_RS05165	COG1174	glycine betaine transport
BC336_RS05175	COG1959	2 iron, 2 sulfur cluster binding
BC336_RS05190	COG0501	Belongs to the peptidase M48B family
BC336_RS05220	COG0586	Pfam SNARE associated Golgi protein
BC336_RS05230	COG0017	Asparaginyl-tRNA synthetase
BC336_RS05255	COG3250	beta-galactosidase activity
BC336_RS05260	COG2211	Major facilitator Superfamily
BC336_RS05260	COG2190	(PTS) system
BC336_RS05270	COG0632	four-way junction helicase activity
BC336_RS05305	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC336_RS05310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC336_RS05315	COG2384	SAM-dependent methyltransferase
BC336_RS05405	COG2217	Heavy metal translocating P-type atpase
BC336_RS05425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC336_RS05430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC336_RS05435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC336_RS05440	COG0358	DNA primase activity
BC336_RS05450	COG0752	glycyl-tRNA synthetase alpha subunit
BC336_RS05455	COG1381	Involved in DNA repair and RecF pathway recombination
BC336_RS05465	COG0295	cytidine deaminase activity
BC336_RS05470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BC336_RS05475	COG1702	phosphate starvation-inducible protein PhoH
BC336_RS05480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BC336_RS05485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC336_RS05495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC336_RS05515	COG0436	Aminotransferase
BC336_RS05535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC336_RS05550	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BC336_RS05555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC336_RS05560	COG0758	DNA mediated transformation
BC336_RS05565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC336_RS05570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC336_RS05580	COG1307	EDD domain protein, DegV family
BC336_RS05585	COG1272	protein, Hemolysin III
BC336_RS05590	COG0617	tRNA 3'-terminal CCA addition
BC336_RS05595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC336_RS05620	COG1132	(ABC) transporter
BC336_RS05625	COG1132	(ABC) transporter
BC336_RS05630	COG0583	DNA-binding transcription factor activity
BC336_RS05645	COG1307	EDD domain protein, DegV family
BC336_RS05675	COG1126	abc transporter atp-binding protein
BC336_RS05680	COG0765	amino acid transport
BC336_RS05685	COG0583	DNA-binding transcription factor activity
BC336_RS05695	COG1316	TRANSCRIPTIONal
BC336_RS05700	COG0628	permease
BC336_RS05705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC336_RS05710	COG1230	cation diffusion facilitator family transporter
BC336_RS05715	COG0640	Transcriptional regulator
BC336_RS05725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC336_RS05725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BC336_RS05730	COG3764	Sortase (surface protein transpeptidase)
BC336_RS05760	COG0196	riboflavin kinase activity
BC336_RS05765	COG0582	viral genome integration into host DNA
BC336_RS05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BC336_RS05790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC336_RS05805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC336_RS05810	COG0626	cystathionine gamma-synthase activity
BC336_RS05815	COG1045	serine acetyltransferase
BC336_RS05830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC336_RS05840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BC336_RS05850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BC336_RS05855	COG0195	Participates in both transcription termination and antitermination
BC336_RS05875	COG0750	zinc metalloprotease
BC336_RS05880	COG4589	Belongs to the CDS family
BC336_RS05885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC336_RS05890	COG0233	cytoplasmic translational termination
BC336_RS05910	COG2827	Endonuclease containing a URI domain
BC336_RS05915	COG0204	Acyl-transferase
BC336_RS05920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC336_RS05925	COG0527	aspartate kinase activity
BC336_RS05930	COG0460	homoserine dehydrogenase
BC336_RS05940	COG1132	(ABC) transporter
BC336_RS05945	COG1132	(ABC) transporter
BC336_RS05950	COG3763	UPF0154 protein
BC336_RS05955	COG4224	UPF0291 protein
BC336_RS05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC336_RS05980	COG1205	dead DEAH box helicase
BC336_RS05980	COG1111	helicase
BC336_RS05995	COG0737	Belongs to the 5'-nucleotidase family
BC336_RS06025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC336_RS06030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BC336_RS06040	COG0552	protein localization to endoplasmic reticulum
BC336_RS06045	COG1196	nuclear chromosome segregation
BC336_RS06050	COG0571	ribonuclease III activity
BC336_RS06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC336_RS06070	COG0601	transmembrane transport
BC336_RS06075	COG4608	Belongs to the ABC transporter superfamily
BC336_RS06085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC336_RS06090	COG0416	fatty acid biosynthetic process
BC336_RS06095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC336_RS06150	COG1162	GTPase activity
BC336_RS06155	COG0515	serine threonine protein kinase
BC336_RS06155	COG2815	serine threonine protein kinase
BC336_RS06165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC336_RS06165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC336_RS06175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC336_RS06185	COG0194	GDP metabolic process
BC336_RS06210	COG4166	transmembrane transport
BC336_RS06215	COG0497	DNA recombination
BC336_RS06220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BC336_RS06230	COG1722	exodeoxyribonuclease VII activity
BC336_RS06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC336_RS06250	COG1302	Protein conserved in bacteria
BC336_RS06255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC336_RS06260	COG0006	proline dipeptidase activity
BC336_RS06290	COG0151	Belongs to the GarS family
BC336_RS06300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC336_RS06320	COG0047	phosphoribosylformylglycinamidine synthase activity
BC336_RS06325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC336_RS06330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC336_RS06335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC336_RS06340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC336_RS06345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC336_RS06375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC336_RS06390	COG0477	Major facilitator Superfamily
BC336_RS06400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC336_RS06410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BC336_RS06415	COG3590	peptidase
BC336_RS06425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BC336_RS06465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC336_RS06480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC336_RS06490	COG0768	penicillin binding
BC336_RS06505	COG0072	phenylalanine-tRNA ligase activity
BC336_RS06510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC336_RS06515	COG1733	regulation of RNA biosynthetic process
BC336_RS06520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC336_RS06525	COG1254	Belongs to the acylphosphatase family
BC336_RS06530	COG0706	membrane insertase activity
BC336_RS06535	COG5002	protein histidine kinase activity
BC336_RS06540	COG0745	RESPONSE REGULATOR receiver
BC336_RS06555	COG0799	negative regulation of ribosome biogenesis
BC336_RS06565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC336_RS06570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC336_RS06585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC336_RS06615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC336_RS06620	COG1484	DNA-dependent DNA replication
BC336_RS06635	COG0237	dephospho-CoA kinase activity
BC336_RS06640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC336_RS06645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC336_RS06645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC336_RS06655	COG0477	Major facilitator Superfamily
BC336_RS06680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC336_RS06685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC336_RS06700	COG1131	(ABC) transporter
BC336_RS06705	COG0537	adenosine 5'-monophosphoramidase activity
BC336_RS06715	COG0167	dihydroorotate dehydrogenase activity
BC336_RS06725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC336_RS06730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC336_RS06735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC336_RS06740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BC336_RS06745	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC336_RS06750	COG4717	serine-type aminopeptidase activity
BC336_RS06755	COG0420	3'-5' exonuclease activity
BC336_RS06765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC336_RS06770	COG0564	pseudouridine synthase activity
BC336_RS06780	COG1376	ErfK ybiS ycfS ynhG family protein
BC336_RS06835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BC336_RS06840	COG1686	Belongs to the peptidase S11 family
BC336_RS06860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC336_RS06860	COG0574	Belongs to the PEP-utilizing enzyme family
BC336_RS06865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC336_RS06865	COG0574	Belongs to the PEP-utilizing enzyme family
BC336_RS06885	COG2244	polysaccharide biosynthetic process
BC336_RS06900	COG0671	phosphoesterase, PA-phosphatase related
BC336_RS06905	COG0477	Major facilitator Superfamily
BC336_RS06910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC336_RS06970	COG0586	Pfam SNARE associated Golgi protein
BC336_RS06980	COG0647	UMP catabolic process
BC336_RS06990	COG0737	Belongs to the 5'-nucleotidase family
BC336_RS07020	COG0668	transmembrane transport
BC336_RS07025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC336_RS07035	COG3118	belongs to the thioredoxin family
BC336_RS07040	COG1193	negative regulation of DNA recombination
BC336_RS07065	COG0513	Belongs to the DEAD box helicase family
BC336_RS07070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BC336_RS07075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC336_RS07080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC336_RS07100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC336_RS07120	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BC336_RS07125	COG0488	(ABC) transporter
BC336_RS07140	COG1214	PFAM Peptidase M22, glycoprotease
BC336_RS07160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BC336_RS07170	COG0470	DNA polymerase III
BC336_RS07175	COG3870	Protein conserved in bacteria
BC336_RS07195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC336_RS07200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BC336_RS07210	COG0590	tRNA wobble adenosine to inosine editing
BC336_RS07215	COG2813	Specifically methylates the guanine in position
BC336_RS07245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC336_RS07305	COG0004	ammonium transporteR
BC336_RS07310	COG1215	transferase activity, transferring glycosyl groups
BC336_RS07325	COG0250	Participates in transcription elongation, termination and antitermination
BC336_RS07365	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BC336_RS07385	COG0583	DNA-binding transcription factor activity
BC336_RS07395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC336_RS07405	COG1131	(ABC) transporter
BC336_RS07410	COG1725	Transcriptional regulator
BC336_RS07415	COG4166	transmembrane transport
BC336_RS07420	COG0494	nUDIX hydrolase
BC336_RS07450	COG2814	Major facilitator Superfamily
BC336_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
BC336_RS07490	COG1454	alcohol dehydrogenase
BC336_RS07500	COG1122	ATPase activity
BC336_RS07510	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
BC336_RS07515	COG1113	amino acid transport
BC336_RS07525	COG1131	(ABC) transporter
BC336_RS07590	COG1442	glycosyl transferase family 8
BC336_RS07600	COG0756	dUTP diphosphatase activity
BC336_RS07625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC336_RS07630	COG0588	phosphoglycerate mutase activity
BC336_RS07645	COG0588	phosphoglycerate mutase activity
BC336_RS07665	COG4948	Mandelate Racemase Muconate Lactonizing
BC336_RS07675	COG1737	Transcriptional regulator
BC336_RS07730	COG0083	homoserine kinase activity
BC336_RS07780	COG2190	(PTS) system
BC336_RS07780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC336_RS07780	COG1263	PTS System
BC336_RS07785	COG0205	6-phosphofructokinase activity
BC336_RS07790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC336_RS07800	COG0366	Alpha amylase catalytic
BC336_RS07810	COG0531	amino acid
BC336_RS07860	COG2223	nitrite transmembrane transporter activity
BC336_RS07880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC336_RS07900	COG1113	amino acid transport
BC336_RS07915	COG3716	PTS system mannose fructose sorbose family IID component
BC336_RS07920	COG3715	PTS system
BC336_RS07990	COG0719	Fe-S assembly protein
BC336_RS07995	COG0822	iron-sulfur transferase activity
BC336_RS08000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC336_RS08005	COG0719	Fe-S assembly protein
BC336_RS08010	COG0396	ATPase activity
BC336_RS08020	COG1263	PTS System
BC336_RS08020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC336_RS08020	COG2190	(PTS) system
BC336_RS08040	COG1136	(ABC) transporter
BC336_RS08040	COG0577	efflux transmembrane transporter activity
BC336_RS08065	COG0557	exoribonuclease II activity
BC336_RS08075	COG1368	sulfuric ester hydrolase activity
BC336_RS08085	COG0438	transferase activity, transferring glycosyl groups
BC336_RS08090	COG0438	transferase activity, transferring glycosyl groups
BC336_RS08290	COG0398	Pfam SNARE associated Golgi protein
BC336_RS08310	COG0505	Belongs to the CarA family
BC336_RS08325	COG2409	Drug exporters of the RND superfamily
BC336_RS08325	COG1033	growth of symbiont in host cell
BC336_RS08395	COG1132	(ABC) transporter
BC336_RS08410	COG2267	carboxylic ester hydrolase activity
BC336_RS08420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC336_RS08425	COG1072	(Pantothenic acid kinase))
BC336_RS08445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC336_RS08455	COG1126	abc transporter atp-binding protein
BC336_RS08460	COG0765	amino acid transport
BC336_RS08470	COG3973	AAA domain
BC336_RS08490	COG0584	glycerophosphoryl diester phosphodiesterase
BC336_RS08515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC336_RS08525	COG2246	polysaccharide biosynthetic process
BC336_RS08540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BC336_RS08545	COG3475	LICD family
BC336_RS08555	COG0438	transferase activity, transferring glycosyl groups
BC336_RS08570	COG0438	transferase activity, transferring glycosyl groups
BC336_RS08575	COG1215	transferase activity, transferring glycosyl groups
BC336_RS08585	COG0562	UDP-galactopyranose mutase
BC336_RS08595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC336_RS08635	COG1396	sequence-specific DNA binding
BC336_RS08640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BC336_RS08680	COG1122	ATPase activity
BC336_RS08685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC336_RS08700	COG1091	dTDP-4-dehydrorhamnose reductase activity
BC336_RS08730	COG1213	nucleotidyl transferase
BC336_RS08735	COG4750	Nucleotidyl transferase
BC336_RS08765	COG0438	transferase activity, transferring glycosyl groups
BC336_RS08780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC336_RS08785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC336_RS08790	COG4464	protein tyrosine phosphatase activity
BC336_RS08795	COG0489	protein tyrosine kinase activity
BC336_RS08805	COG1316	TRANSCRIPTIONal
BC336_RS08810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC336_RS08825	COG0791	NLP P60 protein
BC336_RS08825	COG1388	LysM domain
BC336_RS08835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC336_RS08845	COG0194	GDP metabolic process
BC336_RS08880	COG0488	(ABC) transporter
BC336_RS08890	COG1316	TRANSCRIPTIONal
BC336_RS08905	COG1304	FMN binding
BC336_RS08915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC336_RS08920	COG1121	(ABC) transporter
BC336_RS08925	COG0561	phosphatase activity
BC336_RS08930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC336_RS08930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC336_RS08930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC336_RS08935	COG1105	Belongs to the carbohydrate kinase PfkB family
BC336_RS08940	COG1349	DNA-binding transcription factor activity
BC336_RS08950	COG1794	racemase activity, acting on amino acids and derivatives
BC336_RS08970	COG1132	(ABC) transporter
BC336_RS08975	COG1132	(ABC) transporter
BC336_RS08985	COG0012	GTP binding
BC336_RS08990	COG4481	Protein conserved in bacteria
BC336_RS08995	COG1475	DNA binding
BC336_RS09000	COG1192	Involved in chromosome partitioning
BC336_RS09045	COG0431	NADPH-dependent FMN reductase
BC336_RS09050	COG0431	NADPH-dependent FMN reductase
BC336_RS09070	COG1131	(ABC) transporter
BC336_RS09085	COG3022	response to hydroperoxide
BC336_RS09135	COG0471	metal ion transport
BC336_RS09140	COG0114	fumarate hydratase activity
BC336_RS09170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BC336_RS09190	COG3442	glutamine amidotransferase
BC336_RS09230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC336_RS09235	COG0505	Belongs to the CarA family
BC336_RS09240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC336_RS09255	COG0167	dihydroorotate dehydrogenase activity
BC336_RS09265	COG1278	Cold shock
BC336_RS09275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC336_RS09280	COG0697	spore germination
BC336_RS09285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BC336_RS09290	COG0561	phosphatase activity
BC336_RS09330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BC336_RS09345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC336_RS09345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC336_RS09405	COG1309	transcriptional regulator
BC336_RS09410	COG0577	efflux transmembrane transporter activity
BC336_RS09410	COG1136	(ABC) transporter
BC336_RS09425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BC336_RS09435	COG1696	Membrane protein involved in D-alanine export
BC336_RS09440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC336_RS09480	COG2217	Heavy metal translocating P-type atpase
BC336_RS09500	COG1744	ABC transporter substrate-binding protein PnrA-like
BC336_RS09525	COG1744	ABC transporter substrate-binding protein PnrA-like
BC336_RS09550	COG1176	ABC-type spermidine putrescine transport system, permease component I
BC336_RS09560	COG3842	ATPase activity
BC336_RS09570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC336_RS09575	COG1744	ABC transporter substrate-binding protein PnrA-like
BC336_RS09580	COG3845	ABC transporter
BC336_RS09585	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC336_RS09590	COG1079	Belongs to the binding-protein-dependent transport system permease family
BC336_RS09605	COG0656	L-ascorbic acid biosynthetic process
BC336_RS09635	COG3409	Peptidoglycan-binding domain 1 protein
BC336_RS09645	COG1428	Deoxynucleoside kinase
BC336_RS09650	COG1428	Deoxynucleoside kinase
BC336_RS09655	COG0765	amino acid transport
BC336_RS09660	COG1126	abc transporter atp-binding protein
BC336_RS09665	COG2252	PERMEase
BC336_RS09690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC336_RS09695	COG0028	Belongs to the TPP enzyme family
BC336_RS09710	COG0706	membrane insertase activity