locus-tag	class	description
AT236_RS00015	COG0592	DNA-directed DNA polymerase activity
AT236_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AT236_RS00030	COG0187	DNA topoisomerase II activity
AT236_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AT236_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
AT236_RS00045	COG0629	single-stranded DNA binding
AT236_RS00060	COG0359	binds to the 23S rRNA
AT236_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
AT236_RS00075	COG1136	(ABC) transporter
AT236_RS00090	COG1285	pathogenesis
AT236_RS00115	COG1132	(ABC) transporter
AT236_RS00120	COG0515	serine threonine protein kinase
AT236_RS00130	COG4619	ABC transporter
AT236_RS00135	COG0390	transport system, permease component
AT236_RS00190	COG1942	4-Oxalocrotonate Tautomerase
AT236_RS00220	COG1482	cell wall glycoprotein biosynthetic process
AT236_RS00250	COG1191	sigma factor activity
AT236_RS00255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AT236_RS00260	COG0366	Alpha amylase catalytic
AT236_RS00270	COG0463	Glycosyl transferase, family 2
AT236_RS00280	COG1307	EDD domain protein, DegV family
AT236_RS00295	COG0588	phosphoglycerate mutase activity
AT236_RS00330	COG1011	Hydrolase
AT236_RS00340	COG0708	Exodeoxyribonuclease III
AT236_RS00355	COG0656	L-ascorbic acid biosynthetic process
AT236_RS00360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AT236_RS00375	COG2096	Adenosyltransferase
AT236_RS00385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AT236_RS00395	COG0242	peptide deformylase activity
AT236_RS00425	COG1132	(ABC) transporter
AT236_RS00445	COG0583	DNA-binding transcription factor activity
AT236_RS00465	COG1940	carbohydrate kinase activity
AT236_RS00475	COG2814	Major facilitator Superfamily
AT236_RS00490	COG0583	DNA-binding transcription factor activity
AT236_RS00495	COG3976	FMN-binding domain protein
AT236_RS00495	COG1053	succinate dehydrogenase
AT236_RS00530	COG0745	RESPONSE REGULATOR receiver
AT236_RS00535	COG5002	protein histidine kinase activity
AT236_RS00550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AT236_RS00555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AT236_RS00595	COG1122	ATPase activity
AT236_RS00600	COG0477	Major facilitator Superfamily
AT236_RS00610	COG4555	ABC transporter
AT236_RS00635	COG0501	Belongs to the peptidase M48B family
AT236_RS00640	COG1704	LemA family
AT236_RS00645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AT236_RS00665	COG1126	abc transporter atp-binding protein
AT236_RS00670	COG0765	amino acid transport
AT236_RS00680	COG3189	MarR family transcriptional regulator
AT236_RS00685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AT236_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AT236_RS00705	COG0328	RNA-DNA hybrid ribonuclease activity
AT236_RS00715	COG1216	Glycosyl transferase, family 2
AT236_RS00720	COG2267	carboxylic ester hydrolase activity
AT236_RS00725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AT236_RS00740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AT236_RS00750	COG1181	Belongs to the D-alanine--D-alanine ligase family
AT236_RS00770	COG0657	acetylesterase activity
AT236_RS00770	COG2755	lipolytic protein G-D-S-L family
AT236_RS00775	COG0366	Alpha amylase catalytic
AT236_RS00780	COG0366	Alpha amylase catalytic
AT236_RS00785	COG1175	transmembrane transport
AT236_RS00790	COG3833	ABC-type maltose transport systems, permease component
AT236_RS00800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AT236_RS00815	COG2365	Tyrosine phosphatase family
AT236_RS00820	COG0589	response to stress
AT236_RS00830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AT236_RS00835	COG3639	organic phosphonate transmembrane transporter activity
AT236_RS00845	COG4166	transmembrane transport
AT236_RS00860	COG0367	asparagine synthase
AT236_RS00875	COG0602	queuosine metabolic process
AT236_RS00880	COG2151	metal-sulfur cluster biosynthetic enzyme
AT236_RS00890	COG2814	Major facilitator Superfamily
AT236_RS00895	COG4545	Glutaredoxin-related protein
AT236_RS00900	COG3590	peptidase
AT236_RS00930	COG1388	LysM domain
AT236_RS00930	COG1705	Flagellar rod assembly protein muramidase FlgJ
AT236_RS00940	COG0569	domain protein
AT236_RS00940	COG0475	glutathione-regulated potassium exporter activity
AT236_RS00955	COG0588	phosphoglycerate mutase activity
AT236_RS00960	COG1316	TRANSCRIPTIONal
AT236_RS00965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AT236_RS00970	COG1368	sulfuric ester hydrolase activity
AT236_RS00990	COG1051	belongs to the nudix hydrolase family
AT236_RS01000	COG0765	amino acid transport
AT236_RS01005	COG0765	amino acid transport
AT236_RS01010	COG1126	abc transporter atp-binding protein
AT236_RS01045	COG0531	amino acid
AT236_RS01045	COG0531	amino acid
AT236_RS01050	COG1473	amidohydrolase
AT236_RS01070	COG1418	mRNA catabolic process
AT236_RS01080	COG4166	transmembrane transport
AT236_RS01085	COG4166	transmembrane transport
AT236_RS01095	COG4166	transmembrane transport
AT236_RS01100	COG4166	transmembrane transport
AT236_RS01105	COG0601	transmembrane transport
AT236_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AT236_RS01115	COG0444	Belongs to the ABC transporter superfamily
AT236_RS01120	COG4608	Belongs to the ABC transporter superfamily
AT236_RS01140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AT236_RS01145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AT236_RS01150	COG0516	GMP reductase activity
AT236_RS01155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AT236_RS01165	COG2233	PERMEase
AT236_RS01175	COG0516	GMP reductase activity
AT236_RS01175	COG0517	IMP dehydrogenase activity
AT236_RS01200	COG1132	(ABC) transporter
AT236_RS01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AT236_RS01220	COG1126	abc transporter atp-binding protein
AT236_RS01225	COG0765	amino acid transport
AT236_RS01250	COG2040	homocysteine
AT236_RS01260	COG0287	Prephenate dehydrogenase
AT236_RS01260	COG1605	Chorismate mutase
AT236_RS01270	COG0252	asparaginase activity
AT236_RS01290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AT236_RS01300	COG1335	isochorismatase
AT236_RS01345	COG1121	(ABC) transporter
AT236_RS01380	COG2131	deaminase
AT236_RS01390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AT236_RS01395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AT236_RS01395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AT236_RS01400	COG0084	hydrolase, TatD family'
AT236_RS01420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AT236_RS01435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AT236_RS01440	COG1078	dGTPase activity
AT236_RS01450	COG3343	RNA polymerase activity
AT236_RS01455	COG0504	CTP synthase activity
AT236_RS01460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AT236_RS01470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AT236_RS01485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AT236_RS01500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AT236_RS01505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AT236_RS01530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AT236_RS01535	COG4166	transmembrane transport
AT236_RS01540	COG2195	Cleaves the N-terminal amino acid of tripeptides
AT236_RS01545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AT236_RS01550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AT236_RS01560	COG2199	diguanylate cyclase activity
AT236_RS01590	COG1956	GAF domain-containing protein
AT236_RS01595	COG0542	response to heat
AT236_RS01630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AT236_RS01695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AT236_RS01740	COG0563	adenylate kinase activity
AT236_RS01745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AT236_RS01760	COG0202	RNA polymerase activity
AT236_RS01780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AT236_RS01790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AT236_RS01795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AT236_RS01815	COG1051	belongs to the nudix hydrolase family
AT236_RS01825	COG1881	PFAM PEBP family protein
AT236_RS01835	COG0436	Aminotransferase
AT236_RS01870	COG2188	Transcriptional regulator
AT236_RS01875	COG0632	four-way junction helicase activity
AT236_RS01880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AT236_RS01925	COG1131	(ABC) transporter
AT236_RS01930	COG3091	SprT-like family
AT236_RS01945	COG1705	Flagellar rod assembly protein muramidase FlgJ
AT236_RS01960	COG4851	CamS sex pheromone cAM373 precursor
AT236_RS01980	COG1597	lipid kinase activity
AT236_RS01990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AT236_RS02010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AT236_RS02030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AT236_RS02070	COG3759	membrane
AT236_RS02075	COG1522	sequence-specific DNA binding
AT236_RS02080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AT236_RS02100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AT236_RS02110	COG0488	(ABC) transporter
AT236_RS02115	COG0477	Major facilitator Superfamily
AT236_RS02140	COG0670	Belongs to the BI1 family
AT236_RS02150	COG4690	dipeptidase activity
AT236_RS02165	COG0572	uridine kinase
AT236_RS02170	COG0572	uridine kinase
AT236_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AT236_RS02185	COG0765	amino acid transport
AT236_RS02190	COG0765	amino acid transport
AT236_RS02195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AT236_RS02205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AT236_RS02235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AT236_RS02250	COG2188	Transcriptional regulator
AT236_RS02270	COG1253	flavin adenine dinucleotide binding
AT236_RS02280	COG0531	amino acid
AT236_RS02295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AT236_RS02330	COG0531	amino acid
AT236_RS02340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AT236_RS02350	COG0716	FMN binding
AT236_RS02355	COG0024	Methionine aminopeptidase
AT236_RS02365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AT236_RS02380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AT236_RS02420	COG0542	response to heat
AT236_RS02430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AT236_RS02440	COG1393	Belongs to the ArsC family
AT236_RS02445	COG4862	establishment of competence for transformation
AT236_RS02465	COG2357	RelA SpoT domain protein
AT236_RS02475	COG0564	pseudouridine synthase activity
AT236_RS02490	COG2706	6-phosphogluconolactonase activity
AT236_RS02495	COG0582	viral genome integration into host DNA
AT236_RS02560	COG0628	permease
AT236_RS02575	COG1280	lysine exporter protein (LysE YggA)
AT236_RS02575	COG1674	ftsk spoiiie
AT236_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
AT236_RS02595	COG1426	Protein conserved in bacteria
AT236_RS02600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AT236_RS02615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AT236_RS02620	COG1739	Uncharacterized protein family UPF0029
AT236_RS02625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AT236_RS02640	COG0653	protein targeting
AT236_RS02645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AT236_RS02655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AT236_RS02665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AT236_RS02670	COG0492	ferredoxin-NADP+ reductase activity
AT236_RS02675	COG0556	nucleotide-excision repair
AT236_RS02680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AT236_RS02710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AT236_RS02715	COG1481	regulation of sporulation
AT236_RS02740	COG3842	ATPase activity
AT236_RS02785	COG0561	phosphatase activity
AT236_RS02790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AT236_RS02795	COG0280	phosphate acetyltransferase
AT236_RS02800	COG0802	atpase or kinase
AT236_RS02815	COG3842	ATPase activity
AT236_RS02825	COG1177	transmembrane transport
AT236_RS02860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AT236_RS02875	COG2217	Heavy metal translocating P-type atpase
AT236_RS02880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AT236_RS02885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AT236_RS02920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AT236_RS02930	COG0531	amino acid
AT236_RS02945	COG0803	Belongs to the bacterial solute-binding protein 9 family
AT236_RS02960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AT236_RS02965	COG1459	type II secretion system
AT236_RS02990	COG0827	DNA restriction-modification system
AT236_RS03005	COG0745	RESPONSE REGULATOR receiver
AT236_RS03010	COG5002	protein histidine kinase activity
AT236_RS03010	COG3850	Histidine kinase
AT236_RS03015	COG1368	sulfuric ester hydrolase activity
AT236_RS03025	COG0166	Belongs to the GPI family
AT236_RS03045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AT236_RS03055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AT236_RS03060	COG1435	thymidine kinase activity
AT236_RS03070	COG2890	protein-(glutamine-N5) methyltransferase activity
AT236_RS03075	COG0009	L-threonylcarbamoyladenylate synthase
AT236_RS03085	COG0356	it plays a direct role in the translocation of protons across the membrane
AT236_RS03090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AT236_RS03105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AT236_RS03130	COG1077	Cell shape determining protein MreB Mrl
AT236_RS03135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AT236_RS03145	COG0772	Belongs to the SEDS family
AT236_RS03160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AT236_RS03175	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AT236_RS03180	COG1104	cysteine desulfurase activity
AT236_RS03190	COG1187	pseudouridine synthase activity
AT236_RS03195	COG0525	valine-tRNA ligase activity
AT236_RS03205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AT236_RS03215	COG1077	Cell shape determining protein MreB Mrl
AT236_RS03220	COG1792	Involved in formation and maintenance of cell shape
AT236_RS03250	COG0768	penicillin binding
AT236_RS03270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AT236_RS03275	COG0849	cell division
AT236_RS03280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AT236_RS03305	COG1278	Cold shock
AT236_RS03320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AT236_RS03325	COG1104	cysteine desulfurase activity
AT236_RS03335	COG0482	sulfurtransferase activity
AT236_RS03340	COG0406	alpha-ribazole phosphatase activity
AT236_RS03350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AT236_RS03355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AT236_RS03370	COG0242	peptide deformylase activity
AT236_RS03375	COG1217	gtp-binding protein TYPA
AT236_RS03390	COG0742	ribosomal rna small subunit methyltransferase
AT236_RS03395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AT236_RS03400	COG3480	Lon protease (S16) C-terminal proteolytic domain
AT236_RS03405	COG1555	photosystem II stabilization
AT236_RS03410	COG0658	competence protein
AT236_RS03410	COG2333	competence protein COMEC
AT236_RS03415	COG1466	dna polymerase III delta subunit
AT236_RS03470	COG4166	transmembrane transport
AT236_RS03480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AT236_RS03490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AT236_RS03505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AT236_RS03515	COG1053	succinate dehydrogenase
AT236_RS03550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AT236_RS03555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AT236_RS03560	COG0583	DNA-binding transcription factor activity
AT236_RS03565	COG0018	arginyl-trna synthetase
AT236_RS03575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AT236_RS03585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AT236_RS03590	COG0514	ATP-dependent DNA helicase (RecQ)
AT236_RS03610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AT236_RS03610	COG2755	lipolytic protein G-D-S-L family
AT236_RS03620	COG0300	oxidoreductase activity
AT236_RS03625	COG0737	Belongs to the 5'-nucleotidase family
AT236_RS03645	COG4475	Protein of unknown function (DUF436)
AT236_RS03660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AT236_RS03680	COG0587	DNA-directed DNA polymerase activity
AT236_RS03695	COG1116	anion transmembrane transporter activity
AT236_RS03705	COG2996	Protein conserved in bacteria
AT236_RS03715	COG0456	acetyltransferase
AT236_RS03725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AT236_RS03730	COG1187	pseudouridine synthase activity
AT236_RS03735	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AT236_RS03750	COG0539	negative regulation of cytoplasmic translation
AT236_RS03780	COG0583	DNA-binding transcription factor activity
AT236_RS03805	COG0165	Argininosuccinate lyase
AT236_RS03825	COG3976	FMN-binding domain protein
AT236_RS03825	COG0431	NADPH-dependent FMN reductase
AT236_RS03825	COG1053	succinate dehydrogenase
AT236_RS03830	COG2357	RelA SpoT domain protein
AT236_RS03835	COG0745	RESPONSE REGULATOR receiver
AT236_RS03840	COG5002	protein histidine kinase activity
AT236_RS03850	COG1518	maintenance of DNA repeat elements
AT236_RS03865	COG0183	Belongs to the thiolase family
AT236_RS03875	COG3425	synthase
AT236_RS03885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AT236_RS03895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AT236_RS03900	COG1490	D-aminoacyl-tRNA deacylase activity
AT236_RS03905	COG0124	histidyl-tRNA synthetase
AT236_RS03910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AT236_RS03940	COG0628	permease
AT236_RS03950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AT236_RS03955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AT236_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
AT236_RS03965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AT236_RS03980	COG0439	Biotin carboxylase
AT236_RS03990	COG0825	malonyl-CoA metabolic process
AT236_RS03995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AT236_RS04030	COG1454	alcohol dehydrogenase
AT236_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
AT236_RS04035	COG1454	alcohol dehydrogenase
AT236_RS04160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AT236_RS04180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AT236_RS04185	COG0573	inorganic phosphate transmembrane transporter activity
AT236_RS04190	COG0581	inorganic phosphate transmembrane transporter activity
AT236_RS04195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AT236_RS04200	COG0704	Plays a role in the regulation of phosphate uptake
AT236_RS04210	COG5002	protein histidine kinase activity
AT236_RS04225	COG0488	(ABC) transporter
AT236_RS04245	COG1288	antiporter activity
AT236_RS04250	COG1122	ATPase activity
AT236_RS04255	COG1122	ATPase activity
AT236_RS04290	COG0561	phosphatase activity
AT236_RS04325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AT236_RS04330	COG0187	DNA topoisomerase II activity
AT236_RS04335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AT236_RS04340	COG1227	inorganic diphosphatase activity
AT236_RS04350	COG1304	FMN binding
AT236_RS04375	COG1074	ATP-dependent DNA helicase activity
AT236_RS04380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AT236_RS04380	COG1199	ATP-dependent helicase activity
AT236_RS04390	COG0017	Asparaginyl-tRNA synthetase
AT236_RS04395	COG3935	DnaD domain protein
AT236_RS04400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AT236_RS04405	COG0561	phosphatase activity
AT236_RS04425	COG1506	peptidase
AT236_RS04425	COG0823	Involved in the tonB-independent uptake of proteins
AT236_RS04425	COG4946	Tricorn protease homolog
AT236_RS04430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AT236_RS04440	COG4474	Belongs to the UPF0398 family
AT236_RS04445	COG3599	regulation of cell shape
AT236_RS04455	COG0116	Belongs to the methyltransferase superfamily
AT236_RS04470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AT236_RS04480	COG0564	pseudouridine synthase activity
AT236_RS04485	COG0505	Belongs to the CarA family
AT236_RS04490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AT236_RS04495	COG3830	Belongs to the UPF0237 family
AT236_RS04505	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AT236_RS04510	COG1307	EDD domain protein, DegV family
AT236_RS04535	COG0406	alpha-ribazole phosphatase activity
AT236_RS04560	COG1929	Belongs to the glycerate kinase type-1 family
AT236_RS04585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AT236_RS04610	COG0583	DNA-binding transcription factor activity
AT236_RS04675	COG0582	viral genome integration into host DNA
AT236_RS04700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AT236_RS04710	COG1136	(ABC) transporter
AT236_RS04750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AT236_RS04765	COG0527	aspartate kinase activity
AT236_RS04770	COG2171	N-acyltransferase activity
AT236_RS04775	COG1473	amidohydrolase
AT236_RS04780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AT236_RS04785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AT236_RS04790	COG0436	Aminotransferase
AT236_RS04805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AT236_RS04845	COG1136	(ABC) transporter
AT236_RS04855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AT236_RS04880	COG0582	viral genome integration into host DNA
AT236_RS04945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AT236_RS04955	COG1132	(ABC) transporter
AT236_RS04960	COG1132	(ABC) transporter
AT236_RS04970	COG0328	RNA-DNA hybrid ribonuclease activity
AT236_RS04995	COG0546	phosphoglycolate phosphatase activity
AT236_RS05025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AT236_RS05090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AT236_RS05125	COG1619	proteins homologs of microcin C7 resistance protein MccF
AT236_RS05130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AT236_RS05130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AT236_RS05155	COG2339	peptidase activity
AT236_RS05170	COG1174	glycine betaine transport
AT236_RS05180	COG1959	2 iron, 2 sulfur cluster binding
AT236_RS05190	COG0501	Belongs to the peptidase M48B family
AT236_RS05200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AT236_RS05215	COG0586	Pfam SNARE associated Golgi protein
AT236_RS05225	COG0017	Asparaginyl-tRNA synthetase
AT236_RS05245	COG3250	beta-galactosidase activity
AT236_RS05250	COG2190	(PTS) system
AT236_RS05250	COG2211	Major facilitator Superfamily
AT236_RS05295	COG2195	Cleaves the N-terminal amino acid of tripeptides
AT236_RS05300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AT236_RS05305	COG2384	SAM-dependent methyltransferase
AT236_RS05385	COG2217	Heavy metal translocating P-type atpase
AT236_RS05390	COG2723	6-phospho-beta-galactosidase activity
AT236_RS05395	COG2723	6-phospho-beta-galactosidase activity
AT236_RS05400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AT236_RS05405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AT236_RS05410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AT236_RS05415	COG0358	DNA primase activity
AT236_RS05425	COG0752	glycyl-tRNA synthetase alpha subunit
AT236_RS05440	COG0295	cytidine deaminase activity
AT236_RS05445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AT236_RS05450	COG1702	phosphate starvation-inducible protein PhoH
AT236_RS05465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AT236_RS05485	COG0436	Aminotransferase
AT236_RS05505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AT236_RS05520	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AT236_RS05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AT236_RS05530	COG0758	DNA mediated transformation
AT236_RS05535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AT236_RS05540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AT236_RS05550	COG1307	EDD domain protein, DegV family
AT236_RS05555	COG1272	protein, Hemolysin III
AT236_RS05560	COG0617	tRNA 3'-terminal CCA addition
AT236_RS05565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AT236_RS05590	COG1132	(ABC) transporter
AT236_RS05595	COG1132	(ABC) transporter
AT236_RS05600	COG0583	DNA-binding transcription factor activity
AT236_RS05615	COG1307	EDD domain protein, DegV family
AT236_RS05640	COG1126	abc transporter atp-binding protein
AT236_RS05645	COG0765	amino acid transport
AT236_RS05650	COG0583	DNA-binding transcription factor activity
AT236_RS05665	COG0628	permease
AT236_RS05670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AT236_RS05675	COG1230	cation diffusion facilitator family transporter
AT236_RS05680	COG0640	Transcriptional regulator
AT236_RS05690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AT236_RS05690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AT236_RS05725	COG0196	riboflavin kinase activity
AT236_RS05730	COG0582	viral genome integration into host DNA
AT236_RS05750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AT236_RS05755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AT236_RS05775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AT236_RS05780	COG0626	cystathionine gamma-synthase activity
AT236_RS05785	COG1045	serine acetyltransferase
AT236_RS05800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AT236_RS05810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AT236_RS05820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AT236_RS05825	COG0195	Participates in both transcription termination and antitermination
AT236_RS05845	COG0750	zinc metalloprotease
AT236_RS05850	COG4589	Belongs to the CDS family
AT236_RS05855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AT236_RS05860	COG0233	cytoplasmic translational termination
AT236_RS05880	COG2827	Endonuclease containing a URI domain
AT236_RS05885	COG0204	Acyl-transferase
AT236_RS05890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AT236_RS05895	COG0527	aspartate kinase activity
AT236_RS05900	COG0460	homoserine dehydrogenase
AT236_RS05910	COG1132	(ABC) transporter
AT236_RS05915	COG1132	(ABC) transporter
AT236_RS05920	COG3763	UPF0154 protein
AT236_RS05925	COG4224	UPF0291 protein
AT236_RS05940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AT236_RS05950	COG1111	helicase
AT236_RS05950	COG1205	dead DEAH box helicase
AT236_RS05965	COG0737	Belongs to the 5'-nucleotidase family
AT236_RS05975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AT236_RS06005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AT236_RS06010	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AT236_RS06030	COG0552	protein localization to endoplasmic reticulum
AT236_RS06035	COG1196	nuclear chromosome segregation
AT236_RS06040	COG0571	ribonuclease III activity
AT236_RS06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AT236_RS06060	COG0601	transmembrane transport
AT236_RS06065	COG4608	Belongs to the ABC transporter superfamily
AT236_RS06075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AT236_RS06080	COG0416	fatty acid biosynthetic process
AT236_RS06085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AT236_RS06125	COG0582	viral genome integration into host DNA
AT236_RS06155	COG1162	GTPase activity
AT236_RS06160	COG0515	serine threonine protein kinase
AT236_RS06160	COG2815	serine threonine protein kinase
AT236_RS06170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AT236_RS06170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AT236_RS06180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AT236_RS06190	COG0194	GDP metabolic process
AT236_RS06210	COG4166	transmembrane transport
AT236_RS06215	COG0497	DNA recombination
AT236_RS06220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AT236_RS06230	COG1722	exodeoxyribonuclease VII activity
AT236_RS06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AT236_RS06250	COG1302	Protein conserved in bacteria
AT236_RS06255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AT236_RS06260	COG0006	proline dipeptidase activity
AT236_RS06290	COG0151	Belongs to the GarS family
AT236_RS06300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AT236_RS06320	COG0047	phosphoribosylformylglycinamidine synthase activity
AT236_RS06325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AT236_RS06330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AT236_RS06335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AT236_RS06340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AT236_RS06345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AT236_RS06375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AT236_RS06400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AT236_RS06410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AT236_RS06420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AT236_RS06465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AT236_RS06480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AT236_RS06485	COG0768	penicillin binding
AT236_RS06500	COG0072	phenylalanine-tRNA ligase activity
AT236_RS06505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AT236_RS06510	COG1733	regulation of RNA biosynthetic process
AT236_RS06515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AT236_RS06520	COG1254	Belongs to the acylphosphatase family
AT236_RS06525	COG0706	membrane insertase activity
AT236_RS06530	COG5002	protein histidine kinase activity
AT236_RS06535	COG0745	RESPONSE REGULATOR receiver
AT236_RS06550	COG0799	negative regulation of ribosome biogenesis
AT236_RS06560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AT236_RS06565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AT236_RS06580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AT236_RS06610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AT236_RS06615	COG1484	DNA-dependent DNA replication
AT236_RS06630	COG0237	dephospho-CoA kinase activity
AT236_RS06640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AT236_RS06640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AT236_RS06655	COG2814	Major facilitator Superfamily
AT236_RS06680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AT236_RS06685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AT236_RS06700	COG1131	(ABC) transporter
AT236_RS06705	COG0537	adenosine 5'-monophosphoramidase activity
AT236_RS06715	COG0167	dihydroorotate dehydrogenase activity
AT236_RS06725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AT236_RS06730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AT236_RS06735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AT236_RS06740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AT236_RS06745	COG3481	metal-dependent phosphohydrolase, HD sub domain
AT236_RS06750	COG4717	serine-type aminopeptidase activity
AT236_RS06755	COG0420	3'-5' exonuclease activity
AT236_RS06765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AT236_RS06770	COG0564	pseudouridine synthase activity
AT236_RS06820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AT236_RS06825	COG1686	Belongs to the peptidase S11 family
AT236_RS06845	COG0574	Belongs to the PEP-utilizing enzyme family
AT236_RS06845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AT236_RS06850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AT236_RS06850	COG0574	Belongs to the PEP-utilizing enzyme family
AT236_RS06865	COG2244	polysaccharide biosynthetic process
AT236_RS06880	COG0671	phosphoesterase, PA-phosphatase related
AT236_RS06885	COG0477	Major facilitator Superfamily
AT236_RS06890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AT236_RS06950	COG0586	Pfam SNARE associated Golgi protein
AT236_RS06960	COG0647	UMP catabolic process
AT236_RS06970	COG0737	Belongs to the 5'-nucleotidase family
AT236_RS07010	COG0668	transmembrane transport
AT236_RS07015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AT236_RS07025	COG3118	belongs to the thioredoxin family
AT236_RS07030	COG1193	negative regulation of DNA recombination
AT236_RS07055	COG0513	Belongs to the DEAD box helicase family
AT236_RS07060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AT236_RS07065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AT236_RS07070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AT236_RS07085	COG0632	four-way junction helicase activity
AT236_RS07090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AT236_RS07110	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AT236_RS07115	COG0488	(ABC) transporter
AT236_RS07130	COG1214	PFAM Peptidase M22, glycoprotease
AT236_RS07135	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AT236_RS07155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AT236_RS07165	COG0470	DNA polymerase III
AT236_RS07170	COG3870	Protein conserved in bacteria
AT236_RS07190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AT236_RS07195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AT236_RS07205	COG0590	tRNA wobble adenosine to inosine editing
AT236_RS07210	COG2813	Specifically methylates the guanine in position
AT236_RS07240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AT236_RS07275	COG4166	transmembrane transport
AT236_RS07300	COG0004	ammonium transporteR
AT236_RS07305	COG1215	transferase activity, transferring glycosyl groups
AT236_RS07320	COG0250	Participates in transcription elongation, termination and antitermination
AT236_RS07335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AT236_RS07340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AT236_RS07345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AT236_RS07375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AT236_RS07395	COG0583	DNA-binding transcription factor activity
AT236_RS07405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AT236_RS07415	COG1131	(ABC) transporter
AT236_RS07420	COG1725	Transcriptional regulator
AT236_RS07430	COG0494	nUDIX hydrolase
AT236_RS07485	COG1012	belongs to the aldehyde dehydrogenase family
AT236_RS07485	COG1454	alcohol dehydrogenase
AT236_RS07495	COG1122	ATPase activity
AT236_RS07510	COG1113	amino acid transport
AT236_RS07520	COG1131	(ABC) transporter
AT236_RS07575	COG5001	Diguanylate cyclase
AT236_RS07575	COG3300	MHYT domain
AT236_RS07585	COG1442	glycosyl transferase family 8
AT236_RS07595	COG0756	dUTP diphosphatase activity
AT236_RS07620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AT236_RS07625	COG0588	phosphoglycerate mutase activity
AT236_RS07640	COG0588	phosphoglycerate mutase activity
AT236_RS07660	COG4948	Mandelate Racemase Muconate Lactonizing
AT236_RS07675	COG1737	Transcriptional regulator
AT236_RS07725	COG0083	homoserine kinase activity
AT236_RS07775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AT236_RS07775	COG2190	(PTS) system
AT236_RS07775	COG1263	PTS System
AT236_RS07780	COG0205	6-phosphofructokinase activity
AT236_RS07785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AT236_RS07800	COG0531	amino acid
AT236_RS07840	COG2223	nitrite transmembrane transporter activity
AT236_RS07860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AT236_RS07880	COG1113	amino acid transport
AT236_RS07895	COG3716	PTS system mannose fructose sorbose family IID component
AT236_RS07900	COG3715	PTS system
AT236_RS07915	COG0632	four-way junction helicase activity
AT236_RS07935	COG1757	Na H antiporter
AT236_RS07960	COG4988	ABC transporter
AT236_RS07965	COG0719	Fe-S assembly protein
AT236_RS07970	COG0822	iron-sulfur transferase activity
AT236_RS07975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AT236_RS07980	COG0719	Fe-S assembly protein
AT236_RS07985	COG0396	ATPase activity
AT236_RS07995	COG2190	(PTS) system
AT236_RS08010	COG1136	(ABC) transporter
AT236_RS08010	COG0577	efflux transmembrane transporter activity
AT236_RS08035	COG0557	exoribonuclease II activity
AT236_RS08045	COG1368	sulfuric ester hydrolase activity
AT236_RS08055	COG0438	transferase activity, transferring glycosyl groups
AT236_RS08060	COG0438	transferase activity, transferring glycosyl groups
AT236_RS08255	COG0398	Pfam SNARE associated Golgi protein
AT236_RS08275	COG0505	Belongs to the CarA family
AT236_RS08290	COG2409	Drug exporters of the RND superfamily
AT236_RS08290	COG1033	growth of symbiont in host cell
AT236_RS08360	COG1132	(ABC) transporter
AT236_RS08375	COG2267	carboxylic ester hydrolase activity
AT236_RS08385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AT236_RS08390	COG1072	(Pantothenic acid kinase))
AT236_RS08415	COG1126	abc transporter atp-binding protein
AT236_RS08420	COG3973	AAA domain
AT236_RS08440	COG0584	glycerophosphoryl diester phosphodiesterase
AT236_RS08470	COG2246	polysaccharide biosynthetic process
AT236_RS08515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AT236_RS08520	COG3475	LICD family
AT236_RS08530	COG0438	transferase activity, transferring glycosyl groups
AT236_RS08535	COG0438	transferase activity, transferring glycosyl groups
AT236_RS08540	COG1216	Glycosyl transferase, family 2
AT236_RS08545	COG0562	UDP-galactopyranose mutase
AT236_RS08555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AT236_RS08570	COG1316	TRANSCRIPTIONal
AT236_RS08595	COG1396	sequence-specific DNA binding
AT236_RS08600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AT236_RS08640	COG1122	ATPase activity
AT236_RS08645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AT236_RS08655	COG1088	dTDP-glucose 4,6-dehydratase activity
AT236_RS08665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AT236_RS08690	COG4268	DNA restriction-modification system
AT236_RS08695	COG1401	restriction endodeoxyribonuclease activity
AT236_RS08710	COG0438	transferase activity, transferring glycosyl groups
AT236_RS08720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AT236_RS08745	COG0562	UDP-galactopyranose mutase
AT236_RS08765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AT236_RS08770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AT236_RS08775	COG4464	protein tyrosine phosphatase activity
AT236_RS08780	COG0489	protein tyrosine kinase activity
AT236_RS08790	COG1316	TRANSCRIPTIONal
AT236_RS08805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AT236_RS08820	COG1388	LysM domain
AT236_RS08820	COG0791	NLP P60 protein
AT236_RS08830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AT236_RS08840	COG0194	GDP metabolic process
AT236_RS08880	COG0488	(ABC) transporter
AT236_RS08890	COG1316	TRANSCRIPTIONal
AT236_RS08905	COG1304	FMN binding
AT236_RS08915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AT236_RS08920	COG1121	(ABC) transporter
AT236_RS08925	COG0561	phosphatase activity
AT236_RS08930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AT236_RS08930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AT236_RS08930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AT236_RS08935	COG1105	Belongs to the carbohydrate kinase PfkB family
AT236_RS08940	COG1349	DNA-binding transcription factor activity
AT236_RS08945	COG1794	racemase activity, acting on amino acids and derivatives
AT236_RS08965	COG1132	(ABC) transporter
AT236_RS08970	COG1132	(ABC) transporter
AT236_RS08980	COG0012	GTP binding
AT236_RS08985	COG4481	Protein conserved in bacteria
AT236_RS08990	COG1475	DNA binding
AT236_RS08995	COG1192	Involved in chromosome partitioning
AT236_RS09035	COG0431	NADPH-dependent FMN reductase
AT236_RS09040	COG0431	NADPH-dependent FMN reductase
AT236_RS09060	COG1131	(ABC) transporter
AT236_RS09080	COG1263	PTS System
AT236_RS09080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AT236_RS09080	COG2190	(PTS) system
AT236_RS09090	COG3576	pyridoxamine 5-phosphate
AT236_RS09100	COG1136	(ABC) transporter
AT236_RS09105	COG0577	efflux transmembrane transporter activity
AT236_RS09130	COG3022	response to hydroperoxide
AT236_RS09175	COG0471	metal ion transport
AT236_RS09180	COG0114	fumarate hydratase activity
AT236_RS09210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AT236_RS09225	COG0515	serine threonine protein kinase
AT236_RS09240	COG3442	glutamine amidotransferase
AT236_RS09260	COG1114	Component of the transport system for branched-chain amino acids
AT236_RS09265	COG1278	Cold shock
AT236_RS09270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AT236_RS09275	COG0697	spore germination
AT236_RS09280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AT236_RS09285	COG0561	phosphatase activity
AT236_RS09325	COG1309	transcriptional regulator
AT236_RS09330	COG1136	(ABC) transporter
AT236_RS09330	COG0577	efflux transmembrane transporter activity
AT236_RS09345	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AT236_RS09355	COG1696	Membrane protein involved in D-alanine export
AT236_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AT236_RS09390	COG2217	Heavy metal translocating P-type atpase
AT236_RS09410	COG1744	ABC transporter substrate-binding protein PnrA-like
AT236_RS09435	COG1744	ABC transporter substrate-binding protein PnrA-like
AT236_RS09465	COG3842	ATPase activity
AT236_RS09480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AT236_RS09485	COG1744	ABC transporter substrate-binding protein PnrA-like
AT236_RS09490	COG3845	ABC transporter
AT236_RS09495	COG4603	Belongs to the binding-protein-dependent transport system permease family
AT236_RS09500	COG1079	Belongs to the binding-protein-dependent transport system permease family
AT236_RS09515	COG0656	L-ascorbic acid biosynthetic process
AT236_RS09540	COG3409	Peptidoglycan-binding domain 1 protein
AT236_RS09550	COG1428	Deoxynucleoside kinase
AT236_RS09555	COG1428	Deoxynucleoside kinase
AT236_RS09560	COG0765	amino acid transport
AT236_RS09565	COG1126	abc transporter atp-binding protein
AT236_RS09570	COG2252	PERMEase
AT236_RS09580	COG1132	(ABC) transporter
AT236_RS09605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AT236_RS09610	COG0028	Belongs to the TPP enzyme family
AT236_RS09615	COG0445	tRNA wobble uridine modification
AT236_RS09625	COG0706	membrane insertase activity