locus-tag	class	description
LH506_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH506_RS00010	COG0592	DNA-directed DNA polymerase activity
LH506_RS00015	COG2501	S4 domain
LH506_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LH506_RS00025	COG0187	DNA topoisomerase II activity
LH506_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH506_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LH506_RS00040	COG0629	single-stranded DNA binding
LH506_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LH506_RS00055	COG0359	binds to the 23S rRNA
LH506_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LH506_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH506_RS00080	COG1363	Peptidase, m42
LH506_RS00085	COG0531	amino acid
LH506_RS00090	COG0673	inositol 2-dehydrogenase activity
LH506_RS00100	COG4166	transmembrane transport
LH506_RS00105	COG0431	NADPH-dependent FMN reductase
LH506_RS00110	COG1272	protein, Hemolysin III
LH506_RS00125	COG2217	Heavy metal translocating P-type atpase
LH506_RS00130	COG2217	Heavy metal translocating P-type atpase
LH506_RS00140	COG2814	Major facilitator Superfamily
LH506_RS00160	COG4975	Glucose uptake
LH506_RS00165	COG3942	CHAP domain
LH506_RS00165	COG1388	LysM domain
LH506_RS00170	COG3442	glutamine amidotransferase
LH506_RS00180	COG2188	Transcriptional regulator
LH506_RS00185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS00190	COG2723	6-phospho-beta-galactosidase activity
LH506_RS00195	COG1482	cell wall glycoprotein biosynthetic process
LH506_RS00200	COG0789	Transcriptional regulator
LH506_RS00205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH506_RS00210	COG1554	hydrolase, family 65, central catalytic
LH506_RS00215	COG2190	(PTS) system
LH506_RS00215	COG1263	PTS System
LH506_RS00215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS00225	COG2188	Transcriptional regulator
LH506_RS00230	COG0561	phosphatase activity
LH506_RS00240	COG2814	Major facilitator Superfamily
LH506_RS00275	COG0778	Nitroreductase
LH506_RS00305	COG0308	aminopeptidase N
LH506_RS00310	COG0308	aminopeptidase N
LH506_RS00325	COG0028	Belongs to the TPP enzyme family
LH506_RS00330	COG3527	Alpha-acetolactate decarboxylase
LH506_RS00340	COG3610	response to peptide
LH506_RS00345	COG0583	DNA-binding transcription factor activity
LH506_RS00350	COG0163	prenyltransferase activity
LH506_RS00365	COG0583	DNA-binding transcription factor activity
LH506_RS00370	COG0281	malic enzyme
LH506_RS00405	COG0366	Alpha amylase catalytic
LH506_RS00410	COG4152	abc transporter atp-binding protein
LH506_RS00415	COG1668	transmembrane transport
LH506_RS00425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH506_RS00430	COG2321	neutral zinc metallopeptidase
LH506_RS00435	COG4166	transmembrane transport
LH506_RS00440	COG4166	transmembrane transport
LH506_RS00445	COG0601	transmembrane transport
LH506_RS00450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH506_RS00455	COG0444	Belongs to the ABC transporter superfamily
LH506_RS00460	COG4608	Belongs to the ABC transporter superfamily
LH506_RS00465	COG1464	Belongs to the NlpA lipoprotein family
LH506_RS00470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH506_RS00475	COG2011	ABC-type metal ion transport system permease component
LH506_RS00485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH506_RS00490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH506_RS00495	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LH506_RS00500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH506_RS00505	COG1696	Membrane protein involved in D-alanine export
LH506_RS00510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH506_RS00520	COG0640	Transcriptional regulator
LH506_RS00530	COG0583	DNA-binding transcription factor activity
LH506_RS00535	COG2855	membrane
LH506_RS00545	COG1760	l-serine dehydratase
LH506_RS00550	COG1760	l-serine dehydratase
LH506_RS00560	COG1518	maintenance of DNA repeat elements
LH506_RS00565	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LH506_RS00610	COG4690	dipeptidase activity
LH506_RS00615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH506_RS00625	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH506_RS00635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS00640	COG2723	6-phospho-beta-galactosidase activity
LH506_RS00645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LH506_RS00650	COG1194	a g-specific adenine glycosylase
LH506_RS00660	COG0488	(ABC) transporter
LH506_RS00680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH506_RS00695	COG2252	PERMEase
LH506_RS00705	COG2971	BadF BadG BcrA BcrD
LH506_RS00715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LH506_RS00720	COG1737	Transcriptional regulator
LH506_RS00725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS00765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LH506_RS00770	COG0791	NLP P60 protein
LH506_RS00775	COG1321	iron dependent repressor
LH506_RS00780	COG3158	transport of potassium into the cell
LH506_RS00790	COG3590	peptidase
LH506_RS00820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH506_RS00880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LH506_RS00890	COG2188	Transcriptional regulator
LH506_RS00895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH506_RS00910	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH506_RS00925	COG2183	response to ionizing radiation
LH506_RS00930	COG3091	SprT-like family
LH506_RS00940	COG0363	glucosamine-6-phosphate deaminase activity
LH506_RS00945	COG0531	amino acid
LH506_RS00960	COG1278	Cold shock
LH506_RS00970	COG1705	Flagellar rod assembly protein muramidase FlgJ
LH506_RS00975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH506_RS00980	COG2233	PERMEase
LH506_RS00985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH506_RS00995	COG2910	NAD(P)H-binding
LH506_RS01015	COG1033	growth of symbiont in host cell
LH506_RS01015	COG2409	Drug exporters of the RND superfamily
LH506_RS01040	COG2252	PERMEase
LH506_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH506_RS01050	COG1609	Transcriptional regulator
LH506_RS01055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH506_RS01070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH506_RS01070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS01085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH506_RS01090	COG1660	Displays ATPase and GTPase activities
LH506_RS01095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LH506_RS01100	COG1481	regulation of sporulation
LH506_RS01110	COG0183	Belongs to the thiolase family
LH506_RS01120	COG3425	synthase
LH506_RS01135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH506_RS01145	COG1983	PspC domain protein
LH506_RS01165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LH506_RS01170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH506_RS01175	COG0492	ferredoxin-NADP+ reductase activity
LH506_RS01180	COG1295	ribonuclease BN
LH506_RS01185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH506_RS01190	COG0662	Cupin 2, conserved barrel domain protein
LH506_RS01215	COG1328	CTP reductase activity
LH506_RS01215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH506_RS01220	COG0602	queuosine metabolic process
LH506_RS01225	COG1304	FMN binding
LH506_RS01235	COG0351	phosphomethylpyrimidine kinase
LH506_RS01240	COG0642	Histidine kinase
LH506_RS01245	COG0745	RESPONSE REGULATOR receiver
LH506_RS01255	COG1136	(ABC) transporter
LH506_RS01260	COG0577	efflux transmembrane transporter activity
LH506_RS01265	COG1234	tRNA 3'-trailer cleavage
LH506_RS01270	COG1393	Belongs to the ArsC family
LH506_RS01275	COG4862	establishment of competence for transformation
LH506_RS01290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH506_RS01295	COG0438	transferase activity, transferring glycosyl groups
LH506_RS01300	COG1215	transferase activity, transferring glycosyl groups
LH506_RS01310	COG1216	Glycosyl transferase, family 2
LH506_RS01315	COG5039	Polysaccharide pyruvyl transferase
LH506_RS01330	COG0019	diaminopimelate decarboxylase activity
LH506_RS01335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH506_RS01350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH506_RS01385	COG1253	flavin adenine dinucleotide binding
LH506_RS01395	COG0710	3-dehydroquinate dehydratase activity
LH506_RS01410	COG2801	Transposase and inactivated derivatives
LH506_RS01415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH506_RS01425	COG2365	Tyrosine phosphatase family
LH506_RS01430	COG1929	Belongs to the glycerate kinase type-1 family
LH506_RS01435	COG0589	response to stress
LH506_RS01440	COG2818	Glycosylase
LH506_RS01455	COG4608	Belongs to the ABC transporter superfamily
LH506_RS01460	COG0444	Belongs to the ABC transporter superfamily
LH506_RS01465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH506_RS01470	COG0601	transmembrane transport
LH506_RS01480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH506_RS01495	COG0154	amidase activity
LH506_RS01500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH506_RS01505	COG1597	lipid kinase activity
LH506_RS01510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH506_RS01515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH506_RS01540	COG0531	amino acid
LH506_RS01550	COG0673	inositol 2-dehydrogenase activity
LH506_RS01560	COG1447	Phosphotransferase system cellobiose-specific component IIA
LH506_RS01565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS01585	COG2723	6-phospho-beta-galactosidase activity
LH506_RS01600	COG2309	aminopeptidase activity
LH506_RS01610	COG0516	GMP reductase activity
LH506_RS01615	COG2246	polysaccharide biosynthetic process
LH506_RS01620	COG0716	FMN binding
LH506_RS01635	COG1376	ErfK ybiS ycfS ynhG family protein
LH506_RS01640	COG2226	methyltransferase
LH506_RS01645	COG1418	mRNA catabolic process
LH506_RS01650	COG1428	Deoxynucleoside kinase
LH506_RS01665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH506_RS01670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LH506_RS01675	COG1674	ftsk spoiiie
LH506_RS01685	COG0612	Peptidase, M16
LH506_RS01690	COG0300	oxidoreductase activity
LH506_RS01695	COG1426	Protein conserved in bacteria
LH506_RS01700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH506_RS01710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH506_RS01715	COG1418	mRNA catabolic process
LH506_RS01720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH506_RS01725	COG1739	Uncharacterized protein family UPF0029
LH506_RS01730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LH506_RS01755	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LH506_RS01760	COG1737	Transcriptional regulator
LH506_RS01765	COG0653	protein targeting
LH506_RS01775	COG2884	Cell division ATP-binding protein ftsE
LH506_RS01780	COG2177	Part of the ABC transporter FtsEX involved in
LH506_RS01785	COG0745	RESPONSE REGULATOR receiver
LH506_RS01790	COG5002	protein histidine kinase activity
LH506_RS01800	COG0573	inorganic phosphate transmembrane transporter activity
LH506_RS01805	COG0581	inorganic phosphate transmembrane transporter activity
LH506_RS01810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH506_RS01815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH506_RS01825	COG1609	Transcriptional regulator
LH506_RS01840	COG1695	Transcriptional regulator
LH506_RS01855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH506_RS01860	COG1956	GAF domain-containing protein
LH506_RS01865	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LH506_RS01870	COG1104	cysteine desulfurase activity
LH506_RS01875	COG0301	tRNA thio-modification
LH506_RS01880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LH506_RS01890	COG0525	valine-tRNA ligase activity
LH506_RS01900	COG2003	Belongs to the UPF0758 family
LH506_RS01905	COG1792	Involved in formation and maintenance of cell shape
LH506_RS01915	COG0850	regulation of cytokinetic process
LH506_RS01920	COG2894	cell division
LH506_RS01925	COG0765	amino acid transport
LH506_RS01930	COG1126	abc transporter atp-binding protein
LH506_RS01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH506_RS01960	COG0542	response to heat
LH506_RS01980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH506_RS01985	COG1120	ATPase activity
LH506_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH506_RS02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH506_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH506_RS02015	COG0765	amino acid transport
LH506_RS02020	COG0765	amino acid transport
LH506_RS02035	COG1131	(ABC) transporter
LH506_RS02050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH506_RS02055	COG1136	(ABC) transporter
LH506_RS02060	COG0577	efflux transmembrane transporter activity
LH506_RS02070	COG2267	carboxylic ester hydrolase activity
LH506_RS02075	COG0667	Aldo Keto reductase
LH506_RS02080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH506_RS02085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH506_RS02095	COG3973	AAA domain
LH506_RS02105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH506_RS02105	COG0519	Catalyzes the synthesis of GMP from XMP
LH506_RS02115	COG4708	membrane
LH506_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
LH506_RS02130	COG0531	amino acid
LH506_RS02135	COG0488	(ABC) transporter
LH506_RS02145	COG2261	transglycosylase associated protein
LH506_RS02165	COG0514	ATP-dependent DNA helicase (RecQ)
LH506_RS02170	COG0564	pseudouridine synthase activity
LH506_RS02185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH506_RS02190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH506_RS02195	COG1435	thymidine kinase activity
LH506_RS02200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH506_RS02205	COG2890	protein-(glutamine-N5) methyltransferase activity
LH506_RS02210	COG0009	L-threonylcarbamoyladenylate synthase
LH506_RS02215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH506_RS02225	COG0356	it plays a direct role in the translocation of protons across the membrane
LH506_RS02230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH506_RS02235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH506_RS02240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH506_RS02245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH506_RS02255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH506_RS02260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH506_RS02270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH506_RS02280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LH506_RS02290	COG0772	Belongs to the SEDS family
LH506_RS02300	COG0719	Fe-S assembly protein
LH506_RS02305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH506_RS02315	COG0719	Fe-S assembly protein
LH506_RS02320	COG0530	calcium, potassium:sodium antiporter activity
LH506_RS02335	COG1131	(ABC) transporter
LH506_RS02355	COG2244	polysaccharide biosynthetic process
LH506_RS02360	COG1187	pseudouridine synthase activity
LH506_RS02365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH506_RS02400	COG0561	phosphatase activity
LH506_RS02405	COG0588	phosphoglycerate mutase activity
LH506_RS02410	COG0561	phosphatase activity
LH506_RS02435	COG0318	PFAM AMP-dependent synthetase and ligase
LH506_RS02440	COG0716	FMN binding
LH506_RS02450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH506_RS02455	COG0454	-acetyltransferase
LH506_RS02460	COG0589	response to stress
LH506_RS02470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH506_RS02475	COG5506	Protein of unknown function (DUF1694)
LH506_RS02480	COG4493	Belongs to the UPF0637 family
LH506_RS02490	COG3142	Participates in the control of copper homeostasis
LH506_RS02495	COG1968	undecaprenyl-diphosphatase activity
LH506_RS02500	COG2706	6-phosphogluconolactonase activity
LH506_RS02505	COG3731	PTS system glucitol sorbitol-specific IIA component
LH506_RS02510	COG0628	permease
LH506_RS02515	COG2017	converts alpha-aldose to the beta-anomer
LH506_RS02520	COG0546	phosphoglycolate phosphatase activity
LH506_RS02525	COG1335	isochorismatase
LH506_RS02535	COG1011	Hydrolase
LH506_RS02540	COG0697	spore germination
LH506_RS02550	COG3973	AAA domain
LH506_RS02565	COG0534	Mate efflux family protein
LH506_RS02570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH506_RS02575	COG0284	orotidine-5'-phosphate decarboxylase activity
LH506_RS02580	COG4989	oxidoreductase activity
LH506_RS02585	COG1881	PFAM PEBP family protein
LH506_RS02595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH506_RS02630	COG3842	ATPase activity
LH506_RS02635	COG1801	Protein of unknown function DUF72
LH506_RS02640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH506_RS02640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH506_RS02645	COG0084	hydrolase, TatD family'
LH506_RS02650	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LH506_RS02660	COG4466	Protein conserved in bacteria
LH506_RS02665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH506_RS02670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH506_RS02675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LH506_RS02680	COG1970	mechanosensitive ion channel activity
LH506_RS02685	COG1078	dGTPase activity
LH506_RS02695	COG3343	RNA polymerase activity
LH506_RS02700	COG0504	CTP synthase activity
LH506_RS02705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH506_RS02715	COG2814	Major facilitator Superfamily
LH506_RS02720	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH506_RS02725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH506_RS02750	COG2337	Toxic component of a toxin-antitoxin (TA) module
LH506_RS02760	COG4122	O-methyltransferase activity
LH506_RS02770	COG0039	L-malate dehydrogenase activity
LH506_RS02780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH506_RS02785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LH506_RS02795	COG1098	S1 RNA binding domain
LH506_RS02800	COG0037	tRNA processing
LH506_RS02805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LH506_RS02815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH506_RS02820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH506_RS02825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH506_RS02905	COG4463	regulation of RNA biosynthetic process
LH506_RS02910	COG0542	response to heat
LH506_RS02915	COG0826	peptidase U32
LH506_RS02920	COG0826	peptidase U32
LH506_RS02945	COG0049	tRNA binding
LH506_RS02950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH506_RS02960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH506_RS02965	COG0088	Forms part of the polypeptide exit tunnel
LH506_RS02970	COG0089	rRNA binding
LH506_RS02980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH506_RS02990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH506_RS02995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH506_RS03005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH506_RS03010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH506_RS03015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LH506_RS03020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH506_RS03025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH506_RS03040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LH506_RS03045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH506_RS03070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH506_RS03075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH506_RS03080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LH506_RS03085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH506_RS03095	COG0203	ribosomal protein L17
LH506_RS03105	COG1122	ATPase activity
LH506_RS03115	COG0101	tRNA pseudouridine synthase activity
LH506_RS03120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH506_RS03125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH506_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
LH506_RS03200	COG0716	FMN binding
LH506_RS03220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LH506_RS03225	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH506_RS03235	COG0791	NLP P60 protein
LH506_RS03235	COG0741	lytic transglycosylase activity
LH506_RS03265	COG2946	Replication initiation factor
LH506_RS03280	COG1674	ftsk spoiiie
LH506_RS03310	COG4807	Protein conserved in bacteria
LH506_RS03325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH506_RS03330	COG2801	Transposase and inactivated derivatives
LH506_RS03350	COG3933	PFAM sigma-54 factor interaction domain-containing protein
LH506_RS03350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LH506_RS03365	COG3715	PTS system
LH506_RS03370	COG3716	PTS system mannose fructose sorbose family IID component
LH506_RS03390	COG1940	carbohydrate kinase activity
LH506_RS03400	COG2323	membrane
LH506_RS03405	COG0519	Catalyzes the synthesis of GMP from XMP
LH506_RS03410	COG3104	oligopeptide transport
LH506_RS03420	COG1285	pathogenesis
LH506_RS03425	COG2801	Transposase and inactivated derivatives
LH506_RS03435	COG1012	belongs to the aldehyde dehydrogenase family
LH506_RS03440	COG1695	Transcriptional regulator
LH506_RS03445	COG3479	Phenolic acid decarboxylase
LH506_RS03460	COG0477	Major facilitator Superfamily
LH506_RS03465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LH506_RS03480	COG3189	MarR family transcriptional regulator
LH506_RS03485	COG1827	regulation of RNA biosynthetic process
LH506_RS03490	COG0477	Major facilitator Superfamily
LH506_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
LH506_RS03500	COG0302	gtp cyclohydrolase
LH506_RS03515	COG1937	Protein conserved in bacteria
LH506_RS03520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH506_RS03525	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH506_RS03540	COG2801	Transposase and inactivated derivatives
LH506_RS03555	COG2723	6-phospho-beta-galactosidase activity
LH506_RS03570	COG0406	alpha-ribazole phosphatase activity
LH506_RS03580	COG1940	carbohydrate kinase activity
LH506_RS03600	COG3976	FMN-binding domain protein
LH506_RS03600	COG1053	succinate dehydrogenase
LH506_RS03600	COG0431	NADPH-dependent FMN reductase
LH506_RS03610	COG0531	amino acid
LH506_RS03620	COG1132	(ABC) transporter
LH506_RS03625	COG1132	(ABC) transporter
LH506_RS03630	COG3835	regulator
LH506_RS03635	COG2610	gluconate transmembrane transporter activity
LH506_RS03640	COG1929	Belongs to the glycerate kinase type-1 family
LH506_RS03650	COG0583	DNA-binding transcription factor activity
LH506_RS03655	COG0431	NADPH-dependent FMN reductase
LH506_RS03655	COG3976	FMN-binding domain protein
LH506_RS03655	COG1053	succinate dehydrogenase
LH506_RS03660	COG0431	NADPH-dependent FMN reductase
LH506_RS03660	COG3976	FMN-binding domain protein
LH506_RS03660	COG1053	succinate dehydrogenase
LH506_RS03685	COG3711	transcriptional antiterminator
LH506_RS03690	COG1263	PTS System
LH506_RS03690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS03690	COG2190	(PTS) system
LH506_RS03695	COG2723	6-phospho-beta-galactosidase activity
LH506_RS03705	COG0861	Integral membrane protein TerC family
LH506_RS03710	COG2076	Multidrug Resistance protein
LH506_RS03715	COG0667	Aldo Keto reductase
LH506_RS03740	COG0561	phosphatase activity
LH506_RS03745	COG1162	GTPase activity
LH506_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH506_RS03765	COG2217	Heavy metal translocating P-type atpase
LH506_RS03770	COG0242	peptide deformylase activity
LH506_RS03775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH506_RS03780	COG0640	Transcriptional regulator
LH506_RS03790	COG0628	permease
LH506_RS03800	COG0395	ABC-type sugar transport system, permease component
LH506_RS03805	COG1175	transmembrane transport
LH506_RS03810	COG3842	ATPase activity
LH506_RS03830	COG0561	phosphatase activity
LH506_RS03840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH506_RS03845	COG0280	phosphate acetyltransferase
LH506_RS03850	COG0802	atpase or kinase
LH506_RS03865	COG0708	Exodeoxyribonuclease III
LH506_RS03870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH506_RS03875	COG0604	alcohol dehydrogenase
LH506_RS03885	COG3842	ATPase activity
LH506_RS03890	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH506_RS03895	COG1177	transmembrane transport
LH506_RS03900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LH506_RS03905	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LH506_RS03920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH506_RS03925	COG1307	EDD domain protein, DegV family
LH506_RS03935	COG0561	phosphatase activity
LH506_RS03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LH506_RS03985	COG0827	DNA restriction-modification system
LH506_RS03990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH506_RS04005	COG0582	viral genome integration into host DNA
LH506_RS04095	COG0629	single-stranded DNA binding
LH506_RS04135	COG3728	DNA packaging
LH506_RS04150	COG2369	cell adhesion
LH506_RS04265	COG2337	Toxic component of a toxin-antitoxin (TA) module
LH506_RS04275	COG1442	glycosyl transferase family 8
LH506_RS04280	COG0561	phosphatase activity
LH506_RS04290	COG0745	RESPONSE REGULATOR receiver
LH506_RS04295	COG3850	Histidine kinase
LH506_RS04295	COG5002	protein histidine kinase activity
LH506_RS04300	COG1368	sulfuric ester hydrolase activity
LH506_RS04315	COG0166	Belongs to the GPI family
LH506_RS04320	COG0582	viral genome integration into host DNA
LH506_RS04335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH506_RS04435	COG3728	DNA packaging
LH506_RS04435	COG5484	DNA packaging
LH506_RS04570	COG3942	CHAP domain
LH506_RS04570	COG1388	LysM domain
LH506_RS04590	COG0436	Aminotransferase
LH506_RS04600	COG3715	PTS system
LH506_RS04605	COG3716	PTS system mannose fructose sorbose family IID component
LH506_RS04615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH506_RS04655	COG1132	(ABC) transporter
LH506_RS04665	COG0028	Belongs to the TPP enzyme family
LH506_RS04675	COG0588	phosphoglycerate mutase activity
LH506_RS04695	COG0756	dUTP diphosphatase activity
LH506_RS04700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LH506_RS04705	COG4956	integral membrane protein (PIN domain superfamily)
LH506_RS04710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH506_RS04715	COG0215	cysteine-tRNA ligase activity
LH506_RS04720	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LH506_RS04725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH506_RS04750	COG0233	cytoplasmic translational termination
LH506_RS04755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH506_RS04760	COG4589	Belongs to the CDS family
LH506_RS04765	COG0750	zinc metalloprotease
LH506_RS04770	COG0442	prolyl-tRNA aminoacylation
LH506_RS04775	COG2176	DNA-directed DNA polymerase activity
LH506_RS04785	COG0195	Participates in both transcription termination and antitermination
LH506_RS04790	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LH506_RS04795	COG1358	cellular component organization or biogenesis
LH506_RS04800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH506_RS04805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH506_RS04810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH506_RS04815	COG0196	riboflavin kinase activity
LH506_RS04820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH506_RS04830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH506_RS04835	COG0443	Heat shock 70 kDa protein
LH506_RS04840	COG0484	heat shock protein binding
LH506_RS04850	COG2323	membrane
LH506_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
LH506_RS04880	COG2261	transglycosylase associated protein
LH506_RS04890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LH506_RS04890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH506_RS04910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH506_RS04940	COG0367	asparagine synthase
LH506_RS04955	COG2264	protein methyltransferase activity
LH506_RS04960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH506_RS04970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH506_RS04975	COG1490	D-aminoacyl-tRNA deacylase activity
LH506_RS04980	COG0546	phosphoglycolate phosphatase activity
LH506_RS04985	COG3103	Sh3 type 3 domain protein
LH506_RS04985	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH506_RS04985	COG4991	sh3 domain protein
LH506_RS04990	COG0124	histidyl-tRNA synthetase
LH506_RS05005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LH506_RS05010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LH506_RS05015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH506_RS05020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH506_RS05030	COG1702	phosphate starvation-inducible protein PhoH
LH506_RS05040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH506_RS05055	COG1381	Involved in DNA repair and RecF pathway recombination
LH506_RS05060	COG0752	glycyl-tRNA synthetase alpha subunit
LH506_RS05065	COG0751	glycine-tRNA ligase activity
LH506_RS05075	COG4120	Belongs to the binding-protein-dependent transport system permease family
LH506_RS05085	COG0358	DNA primase activity
LH506_RS05090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH506_RS05095	COG2384	SAM-dependent methyltransferase
LH506_RS05100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LH506_RS05105	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH506_RS05110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH506_RS05115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LH506_RS05120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH506_RS05125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH506_RS05130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH506_RS05135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH506_RS05155	COG1942	4-Oxalocrotonate Tautomerase
LH506_RS05160	COG0667	Aldo Keto reductase
LH506_RS05165	COG0561	phosphatase activity
LH506_RS05170	COG2151	metal-sulfur cluster biosynthetic enzyme
LH506_RS05215	COG3655	Transcriptional regulator
LH506_RS05240	COG1304	FMN binding
LH506_RS05255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LH506_RS05260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LH506_RS05265	COG1074	ATP-dependent DNA helicase activity
LH506_RS05270	COG1199	ATP-dependent helicase activity
LH506_RS05270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH506_RS05280	COG3935	DnaD domain protein
LH506_RS05285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH506_RS05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH506_RS05300	COG3331	DNA recombination
LH506_RS05305	COG4474	Belongs to the UPF0398 family
LH506_RS05310	COG3599	regulation of cell shape
LH506_RS05320	COG0116	Belongs to the methyltransferase superfamily
LH506_RS05330	COG0561	phosphatase activity
LH506_RS05345	COG1518	maintenance of DNA repeat elements
LH506_RS05355	COG3804	dihydrodipicolinate reductase
LH506_RS05360	COG1307	EDD domain protein, DegV family
LH506_RS05385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LH506_RS05390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH506_RS05395	COG0564	pseudouridine synthase activity
LH506_RS05405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LH506_RS05415	COG0505	Belongs to the CarA family
LH506_RS05425	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LH506_RS05430	COG1307	EDD domain protein, DegV family
LH506_RS05445	COG2755	lipolytic protein G-D-S-L family
LH506_RS05445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH506_RS05460	COG1227	inorganic diphosphatase activity
LH506_RS05465	COG0583	DNA-binding transcription factor activity
LH506_RS05470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LH506_RS05485	COG0187	DNA topoisomerase II activity
LH506_RS05490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH506_RS05500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH506_RS05515	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LH506_RS05520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH506_RS05525	COG0758	DNA mediated transformation
LH506_RS05530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH506_RS05535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LH506_RS05570	COG1131	(ABC) transporter
LH506_RS05580	COG2274	protein secretion by the type I secretion system
LH506_RS05595	COG0738	Major facilitator superfamily
LH506_RS05605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH506_RS05620	COG3409	Peptidoglycan-binding domain 1 protein
LH506_RS05620	COG0793	Belongs to the peptidase S41A family
LH506_RS05625	COG4479	Belongs to the UPF0346 family
LH506_RS05635	COG2755	lipolytic protein G-D-S-L family
LH506_RS05640	COG1307	EDD domain protein, DegV family
LH506_RS05655	COG0617	tRNA 3'-terminal CCA addition
LH506_RS05660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LH506_RS05665	COG0457	Tetratricopeptide repeat
LH506_RS05675	COG1160	GTP binding
LH506_RS05680	COG0539	negative regulation of cytoplasmic translation
LH506_RS05690	COG3942	CHAP domain
LH506_RS05690	COG1388	LysM domain
LH506_RS05695	COG0514	ATP-dependent DNA helicase (RecQ)
LH506_RS05710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LH506_RS05715	COG1187	pseudouridine synthase activity
LH506_RS05720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH506_RS05740	COG2996	Protein conserved in bacteria
LH506_RS05745	COG2707	UPF0756 membrane protein
LH506_RS05760	COG0587	DNA-directed DNA polymerase activity
LH506_RS05770	COG2190	(PTS) system
LH506_RS05770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS05770	COG1263	PTS System
LH506_RS05775	COG0737	Belongs to the 5'-nucleotidase family
LH506_RS05795	COG0300	oxidoreductase activity
LH506_RS05800	COG1234	tRNA 3'-trailer cleavage
LH506_RS05810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH506_RS05815	COG1349	DNA-binding transcription factor activity
LH506_RS05820	COG1105	Belongs to the carbohydrate kinase PfkB family
LH506_RS05825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH506_RS05825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH506_RS05825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH506_RS05840	COG0765	amino acid transport
LH506_RS05845	COG0322	excinuclease ABC activity
LH506_RS05850	COG1126	abc transporter atp-binding protein
LH506_RS05860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH506_RS05870	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH506_RS05880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH506_RS05885	COG1266	CAAX protease self-immunity
LH506_RS05895	COG0488	(ABC) transporter
LH506_RS05900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS05905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH506_RS05915	COG1214	PFAM Peptidase M22, glycoprotease
LH506_RS05935	COG4467	Involved in initiation control of chromosome replication
LH506_RS05940	COG0470	DNA polymerase III
LH506_RS05945	COG3870	Protein conserved in bacteria
LH506_RS05950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH506_RS05955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH506_RS05960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH506_RS05965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LH506_RS05970	COG0167	dihydroorotate dehydrogenase activity
LH506_RS05975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH506_RS05980	COG0505	Belongs to the CarA family
LH506_RS05985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH506_RS05990	COG0540	Belongs to the ATCase OTCase family
LH506_RS05995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LH506_RS06005	COG0590	tRNA wobble adenosine to inosine editing
LH506_RS06010	COG2508	Transcriptional regulator
LH506_RS06015	COG2813	Specifically methylates the guanine in position
LH506_RS06030	COG2801	Transposase and inactivated derivatives
LH506_RS06040	COG0222	ribosome binding
LH506_RS06045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH506_RS06050	COG0081	regulation of translation
LH506_RS06060	COG0250	Participates in transcription elongation, termination and antitermination
LH506_RS06070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH506_RS06075	COG2827	Endonuclease containing a URI domain
LH506_RS06080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH506_RS06085	COG0204	Acyl-transferase
LH506_RS06090	COG3763	UPF0154 protein
LH506_RS06095	COG4224	UPF0291 protein
LH506_RS06100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH506_RS06105	COG0501	Belongs to the peptidase M48B family
LH506_RS06110	COG1704	LemA family
LH506_RS06120	COG0335	large ribosomal subunit rRNA binding
LH506_RS06135	COG1837	Belongs to the UPF0109 family
LH506_RS06145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH506_RS06150	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LH506_RS06155	COG0552	protein localization to endoplasmic reticulum
LH506_RS06160	COG1196	nuclear chromosome segregation
LH506_RS06165	COG0571	ribonuclease III activity
LH506_RS06170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH506_RS06175	COG0416	fatty acid biosynthetic process
LH506_RS06180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH506_RS06185	COG1461	Dihydroxyacetone kinase
LH506_RS06190	COG1302	Protein conserved in bacteria
LH506_RS06195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH506_RS06200	COG1564	THIamine pyrophosphokinase
LH506_RS06205	COG1162	GTPase activity
LH506_RS06220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH506_RS06220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH506_RS06225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH506_RS06230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH506_RS06235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH506_RS06245	COG0194	GDP metabolic process
LH506_RS06255	COG0497	DNA recombination
LH506_RS06260	COG1438	arginine binding
LH506_RS06265	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LH506_RS06280	COG1570	exodeoxyribonuclease VII activity
LH506_RS06285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH506_RS06295	COG1302	Protein conserved in bacteria
LH506_RS06300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH506_RS06305	COG0006	proline dipeptidase activity
LH506_RS06310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LH506_RS06315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH506_RS06320	COG1811	Na channel or pump
LH506_RS06330	COG2936	dipeptidyl-peptidase activity
LH506_RS06335	COG0174	glutamine synthetase
LH506_RS06340	COG0789	Transcriptional regulator
LH506_RS06345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH506_RS06360	COG1940	carbohydrate kinase activity
LH506_RS06370	COG0457	Tetratricopeptide repeat
LH506_RS06370	COG0705	Rhomboid family
LH506_RS06375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH506_RS06380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH506_RS06385	COG0768	penicillin binding
LH506_RS06395	COG2197	response regulator
LH506_RS06400	COG4585	Histidine kinase
LH506_RS06410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH506_RS06415	COG0572	uridine kinase
LH506_RS06420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH506_RS06425	COG0072	phenylalanine-tRNA ligase activity
LH506_RS06435	COG1733	regulation of RNA biosynthetic process
LH506_RS06445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH506_RS06450	COG1254	Belongs to the acylphosphatase family
LH506_RS06455	COG0706	membrane insertase activity
LH506_RS06460	COG5002	protein histidine kinase activity
LH506_RS06465	COG0745	RESPONSE REGULATOR receiver
LH506_RS06480	COG0531	amino acid
LH506_RS06485	COG1982	Orn Lys Arg decarboxylase major
LH506_RS06490	COG1288	antiporter activity
LH506_RS06495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LH506_RS06515	COG0463	Glycosyl transferase, family 2
LH506_RS06520	COG1088	dTDP-glucose 4,6-dehydratase activity
LH506_RS06525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH506_RS06530	COG2246	polysaccharide biosynthetic process
LH506_RS06545	COG1705	Flagellar rod assembly protein muramidase FlgJ
LH506_RS06555	COG2801	Transposase and inactivated derivatives
LH506_RS06575	COG0438	transferase activity, transferring glycosyl groups
LH506_RS06585	COG1216	Glycosyl transferase, family 2
LH506_RS06590	COG1088	dTDP-glucose 4,6-dehydratase activity
LH506_RS06600	COG3475	LICD family
LH506_RS06605	COG1216	Glycosyl transferase, family 2
LH506_RS06610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH506_RS06630	COG1012	belongs to the aldehyde dehydrogenase family
LH506_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH506_RS06640	COG5549	protein import
LH506_RS06645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LH506_RS06655	COG1323	Belongs to the UPF0348 family
LH506_RS06660	COG2226	methyltransferase
LH506_RS06665	COG0799	negative regulation of ribosome biogenesis
LH506_RS06670	COG1713	HD superfamily hydrolase involved in NAD metabolism
LH506_RS06675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH506_RS06685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LH506_RS06690	COG0647	UMP catabolic process
LH506_RS06695	COG0656	L-ascorbic acid biosynthetic process
LH506_RS06700	COG2382	esterase
LH506_RS06705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LH506_RS06715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH506_RS06725	COG1484	DNA-dependent DNA replication
LH506_RS06730	COG3611	Membrane attachment protein
LH506_RS06740	COG0237	dephospho-CoA kinase activity
LH506_RS06750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH506_RS06750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH506_RS06755	COG0110	maltose O-acetyltransferase activity
LH506_RS06760	COG0346	lactoylglutathione lyase activity
LH506_RS06765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH506_RS06770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH506_RS06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH506_RS06790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LH506_RS06795	COG4473	ABC transporter
LH506_RS06800	COG1131	(ABC) transporter
LH506_RS06805	COG0537	adenosine 5'-monophosphoramidase activity
LH506_RS06815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH506_RS06825	COG3679	Belongs to the UPF0342 family
LH506_RS06830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH506_RS06835	COG0564	pseudouridine synthase activity
LH506_RS06840	COG1079	Belongs to the binding-protein-dependent transport system permease family
LH506_RS06845	COG4603	Belongs to the binding-protein-dependent transport system permease family
LH506_RS06850	COG3845	ABC transporter
LH506_RS06855	COG1744	ABC transporter substrate-binding protein PnrA-like
LH506_RS06865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS06865	COG1263	PTS System
LH506_RS06865	COG2190	(PTS) system
LH506_RS06870	COG1438	arginine binding
LH506_RS06875	COG0018	arginyl-trna synthetase
LH506_RS06880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH506_RS06890	COG1012	belongs to the aldehyde dehydrogenase family
LH506_RS06890	COG1454	alcohol dehydrogenase
LH506_RS06895	COG1862	Preprotein translocase
LH506_RS06900	COG0343	queuine tRNA-ribosyltransferase activity
LH506_RS06905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH506_RS06910	COG2255	four-way junction helicase activity
LH506_RS06925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH506_RS06930	COG1692	metallophosphoesterase
LH506_RS06935	COG0671	phosphoesterase, PA-phosphatase related
LH506_RS06940	COG0477	Major facilitator Superfamily
LH506_RS06945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH506_RS06965	COG1316	TRANSCRIPTIONal
LH506_RS06970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LH506_RS06975	COG0557	exoribonuclease II activity
LH506_RS06985	COG0148	phosphopyruvate hydratase activity
LH506_RS06990	COG0149	triose-phosphate isomerase activity
LH506_RS06995	COG0126	phosphoglycerate kinase activity
LH506_RS07005	COG2390	Transcriptional regulator
LH506_RS07165	COG1098	S1 RNA binding domain
LH506_RS07170	COG0492	ferredoxin-NADP+ reductase activity
LH506_RS07175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LH506_RS07185	COG0647	UMP catabolic process
LH506_RS07190	COG4470	Protein conserved in bacteria
LH506_RS07200	COG0584	glycerophosphoryl diester phosphodiesterase
LH506_RS07205	COG0640	Transcriptional regulator
LH506_RS07225	COG1609	Transcriptional regulator
LH506_RS07230	COG0006	proline dipeptidase activity
LH506_RS07245	COG0668	transmembrane transport
LH506_RS07250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH506_RS07255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LH506_RS07260	COG0151	Belongs to the GarS family
LH506_RS07265	COG0138	bifunctional purine biosynthesis protein purh
LH506_RS07270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH506_RS07275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH506_RS07290	COG0047	phosphoribosylformylglycinamidine synthase activity
LH506_RS07305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH506_RS07310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH506_RS07320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH506_RS07325	COG0622	Phosphoesterase
LH506_RS07330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH506_RS07345	COG3118	belongs to the thioredoxin family
LH506_RS07350	COG1193	negative regulation of DNA recombination
LH506_RS07365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH506_RS07375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH506_RS07385	COG0513	Belongs to the DEAD box helicase family
LH506_RS07390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LH506_RS07395	COG4109	DRTGG domain
LH506_RS07415	COG1185	polyribonucleotide nucleotidyltransferase activity
LH506_RS07430	COG1466	dna polymerase III delta subunit
LH506_RS07435	COG0658	competence protein
LH506_RS07435	COG2333	competence protein COMEC
LH506_RS07440	COG1596	polysaccharide export
LH506_RS07440	COG1555	photosystem II stabilization
LH506_RS07445	COG3480	Lon protease (S16) C-terminal proteolytic domain
LH506_RS07450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH506_RS07455	COG0742	ribosomal rna small subunit methyltransferase
LH506_RS07460	COG4471	UPF0298 protein
LH506_RS07465	COG0772	Belongs to the SEDS family
LH506_RS07470	COG1217	gtp-binding protein TYPA
LH506_RS07475	COG0483	inositol monophosphate 1-phosphatase activity
LH506_RS07485	COG0242	peptide deformylase activity
LH506_RS07490	COG2801	Transposase and inactivated derivatives
LH506_RS07520	COG0735	belongs to the Fur family
LH506_RS07525	COG1368	sulfuric ester hydrolase activity
LH506_RS07540	COG0438	transferase activity, transferring glycosyl groups
LH506_RS07550	COG1132	(ABC) transporter
LH506_RS07560	COG1309	transcriptional regulator
LH506_RS07565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH506_RS07580	COG3833	ABC-type maltose transport systems, permease component
LH506_RS07585	COG1175	transmembrane transport
LH506_RS07590	COG2182	Extracellular solute-binding protein
LH506_RS07595	COG0366	Alpha amylase catalytic
LH506_RS07600	COG1609	Transcriptional regulator
LH506_RS07605	COG0390	transport system, permease component
LH506_RS07610	COG4619	ABC transporter
LH506_RS07630	COG1597	lipid kinase activity
LH506_RS07635	COG1733	regulation of RNA biosynthetic process
LH506_RS07645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LH506_RS07670	COG1104	cysteine desulfurase activity
LH506_RS07685	COG0494	nUDIX hydrolase
LH506_RS07695	COG3853	Toxic anion resistance protein (TelA)
LH506_RS07700	COG1278	Cold shock
LH506_RS07705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH506_RS07710	COG3599	regulation of cell shape
LH506_RS07715	COG2302	S4 RNA-binding domain
LH506_RS07725	COG1799	cell septum assembly
LH506_RS07740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LH506_RS07750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH506_RS07755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH506_RS07760	COG0768	penicillin binding
LH506_RS07770	COG0275	rRNA processing
LH506_RS07790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH506_RS07795	COG1253	flavin adenine dinucleotide binding
LH506_RS07800	COG0628	permease
LH506_RS07825	COG3557	Belongs to the UPF0374 family
LH506_RS07830	COG2137	regulation of response to DNA damage stimulus
LH506_RS07835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH506_RS07850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH506_RS07870	COG0586	Pfam SNARE associated Golgi protein
LH506_RS07875	COG1136	(ABC) transporter
LH506_RS07880	COG0577	efflux transmembrane transporter activity
LH506_RS07890	COG1136	(ABC) transporter
LH506_RS07890	COG0577	efflux transmembrane transporter activity
LH506_RS07895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH506_RS07900	COG3548	integral membrane protein
LH506_RS07910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LH506_RS07920	COG0583	DNA-binding transcription factor activity
LH506_RS07930	COG1846	Transcriptional regulator
LH506_RS07940	COG0588	phosphoglycerate mutase activity
LH506_RS07945	COG0519	Catalyzes the synthesis of GMP from XMP
LH506_RS07950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH506_RS07955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH506_RS07965	COG0577	efflux transmembrane transporter activity
LH506_RS08035	COG1316	TRANSCRIPTIONal
LH506_RS08045	COG1136	(ABC) transporter
LH506_RS08050	COG0386	Belongs to the glutathione peroxidase family
LH506_RS08065	COG1216	Glycosyl transferase, family 2
LH506_RS08070	COG2365	Tyrosine phosphatase family
LH506_RS08075	COG1073	alpha beta
LH506_RS08080	COG1285	pathogenesis
LH506_RS08085	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH506_RS08095	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LH506_RS08100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LH506_RS08105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH506_RS08110	COG1609	Transcriptional regulator
LH506_RS08120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH506_RS08125	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LH506_RS08130	COG2188	Transcriptional regulator
LH506_RS08140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH506_RS08165	COG0366	Alpha amylase catalytic
LH506_RS08175	COG1609	Transcriptional regulator
LH506_RS08180	COG0395	ABC-type sugar transport system, permease component
LH506_RS08195	COG3459	Glycosyltransferase 36 associated
LH506_RS08215	COG0383	alpha-mannosidase activity
LH506_RS08235	COG4753	response regulator
LH506_RS08235	COG2207	Transcriptional regulator
LH506_RS08240	COG2972	Histidine kinase
LH506_RS08250	COG1653	transport
LH506_RS08255	COG0395	ABC-type sugar transport system, permease component
LH506_RS08270	COG1132	(ABC) transporter
LH506_RS08275	COG1132	(ABC) transporter
LH506_RS08290	COG2801	Transposase and inactivated derivatives
LH506_RS08305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS08315	COG2188	Transcriptional regulator
LH506_RS08320	COG2084	Dehydrogenase
LH506_RS08325	COG0745	RESPONSE REGULATOR receiver
LH506_RS08330	COG0704	Plays a role in the regulation of phosphate uptake
LH506_RS08335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH506_RS08345	COG0581	inorganic phosphate transmembrane transporter activity
LH506_RS08350	COG0573	inorganic phosphate transmembrane transporter activity
LH506_RS08360	COG2239	Acts as a magnesium transporter
LH506_RS08365	COG0564	pseudouridine synthase activity
LH506_RS08370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH506_RS08375	COG2357	RelA SpoT domain protein
LH506_RS08400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH506_RS08405	COG1132	(ABC) transporter
LH506_RS08410	COG1132	(ABC) transporter
LH506_RS08415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH506_RS08425	COG0328	RNA-DNA hybrid ribonuclease activity
LH506_RS08440	COG2738	Putative neutral zinc metallopeptidase
LH506_RS08445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH506_RS08455	COG2217	Heavy metal translocating P-type atpase
LH506_RS08465	COG2094	Belongs to the DNA glycosylase MPG family
LH506_RS08480	COG0604	alcohol dehydrogenase
LH506_RS08500	COG1846	Transcriptional regulator
LH506_RS08505	COG0477	Major facilitator Superfamily
LH506_RS08510	COG3022	response to hydroperoxide
LH506_RS08545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LH506_RS08560	COG1472	Belongs to the glycosyl hydrolase 3 family
LH506_RS08565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH506_RS08585	COG2801	Transposase and inactivated derivatives
LH506_RS08590	COG0194	GDP metabolic process
LH506_RS08605	COG0583	DNA-binding transcription factor activity
LH506_RS08610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH506_RS08615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH506_RS08625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH506_RS08635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH506_RS08650	COG1199	ATP-dependent helicase activity
LH506_RS08660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LH506_RS08665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LH506_RS08670	COG2261	transglycosylase associated protein
LH506_RS08680	COG0028	Belongs to the TPP enzyme family
LH506_RS08700	COG0488	(ABC) transporter
LH506_RS08710	COG1301	dicarboxylic acid transport
LH506_RS08715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH506_RS08725	COG1316	TRANSCRIPTIONal
LH506_RS08730	COG1164	Oligoendopeptidase f
LH506_RS08735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH506_RS08740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH506_RS08755	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH506_RS08765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH506_RS08770	COG1686	Belongs to the peptidase S11 family
LH506_RS08790	COG1914	H( )-stimulated, divalent metal cation uptake system
LH506_RS08795	COG0517	IMP dehydrogenase activity
LH506_RS08795	COG0516	GMP reductase activity
LH506_RS08820	COG0012	GTP binding
LH506_RS08825	COG4481	Protein conserved in bacteria
LH506_RS08830	COG1475	DNA binding
LH506_RS08835	COG1192	Involved in chromosome partitioning
LH506_RS08860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH506_RS08870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH506_RS08875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH506_RS08895	COG0745	RESPONSE REGULATOR receiver
LH506_RS08910	COG1511	domain protein
LH506_RS08915	COG3394	polysaccharide catabolic process
LH506_RS08920	COG1263	PTS System
LH506_RS08920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH506_RS08930	COG2190	(PTS) system
LH506_RS08945	COG1230	cation diffusion facilitator family transporter
LH506_RS08955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LH506_RS08960	COG0765	amino acid transport
LH506_RS08970	COG0419	ATPase involved in DNA repair
LH506_RS08975	COG0420	3'-5' exonuclease activity
LH506_RS08995	COG0038	chloride channel
LH506_RS09015	COG0706	membrane insertase activity
LH506_RS09020	COG0594	ribonuclease P activity