locus-tag	class	description
N573_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N573_RS00010	COG0592	DNA-directed DNA polymerase activity
N573_RS00015	COG2501	S4 domain
N573_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N573_RS00025	COG0187	DNA topoisomerase II activity
N573_RS00045	COG0360	Binds together with S18 to 16S ribosomal RNA
N573_RS00050	COG0629	single-stranded DNA binding
N573_RS00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N573_RS00065	COG0359	binds to the 23S rRNA
N573_RS00070	COG0305	Participates in initiation and elongation during chromosome replication
N573_RS00090	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS00105	COG0745	RESPONSE REGULATOR receiver
N573_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N573_RS00130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N573_RS00135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N573_RS00140	COG1959	2 iron, 2 sulfur cluster binding
N573_RS00145	COG1609	Transcriptional regulator
N573_RS00155	COG1554	hydrolase, family 65, central catalytic
N573_RS00160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N573_RS00185	COG0436	Aminotransferase
N573_RS00205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N573_RS00210	COG1074	ATP-dependent DNA helicase activity
N573_RS00215	COG0656	L-ascorbic acid biosynthetic process
N573_RS00265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N573_RS00270	COG1012	belongs to the aldehyde dehydrogenase family
N573_RS00275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N573_RS00280	COG0284	orotidine-5'-phosphate decarboxylase activity
N573_RS00285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N573_RS00300	COG0438	transferase activity, transferring glycosyl groups
N573_RS00330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N573_RS00335	COG1114	Component of the transport system for branched-chain amino acids
N573_RS00340	COG0667	Aldo Keto reductase
N573_RS00345	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
N573_RS00360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N573_RS00370	COG0420	3'-5' exonuclease activity
N573_RS00375	COG0419	ATPase involved in DNA repair
N573_RS00380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N573_RS00385	COG0675	Transposase, IS605 OrfB family
N573_RS00405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N573_RS00410	COG0765	amino acid transport
N573_RS00420	COG1113	amino acid transport
N573_RS00430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N573_RS00445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N573_RS00455	COG0357	Ribosomal RNA small subunit methyltransferase G
N573_RS00465	COG1475	DNA binding
N573_RS00470	COG4481	Protein conserved in bacteria
N573_RS00475	COG0012	GTP binding
N573_RS00485	COG0517	IMP dehydrogenase activity
N573_RS00485	COG0516	GMP reductase activity
N573_RS00490	COG1316	TRANSCRIPTIONal
N573_RS00500	COG0489	protein tyrosine kinase activity
N573_RS00510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N573_RS00530	COG1216	Glycosyl transferase, family 2
N573_RS00535	COG2801	Transposase and inactivated derivatives
N573_RS00585	COG3328	transposase activity
N573_RS00595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N573_RS00605	COG1088	dTDP-glucose 4,6-dehydratase activity
N573_RS00610	COG1091	dTDP-4-dehydrorhamnose reductase activity
N573_RS00625	COG0745	RESPONSE REGULATOR receiver
N573_RS00635	COG1686	Belongs to the peptidase S11 family
N573_RS00660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N573_RS00670	COG0628	permease
N573_RS00675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N573_RS00680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N573_RS00685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N573_RS00690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N573_RS00720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N573_RS00725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N573_RS00730	COG0047	phosphoribosylformylglycinamidine synthase activity
N573_RS00735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N573_RS00745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N573_RS00750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N573_RS00755	COG0138	bifunctional purine biosynthesis protein purh
N573_RS00760	COG0151	Belongs to the GarS family
N573_RS00765	COG0588	phosphoglycerate mutase activity
N573_RS00770	COG0436	Aminotransferase
N573_RS00855	COG1609	Transcriptional regulator
N573_RS00880	COG1942	4-Oxalocrotonate Tautomerase
N573_RS00915	COG0667	Aldo Keto reductase
N573_RS00935	COG0697	spore germination
N573_RS00970	COG1120	ATPase activity
N573_RS00975	COG0477	Major facilitator Superfamily
N573_RS00985	COG0708	Exodeoxyribonuclease III
N573_RS01015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N573_RS01025	COG2508	Transcriptional regulator
N573_RS01030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N573_RS01035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N573_RS01040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N573_RS01045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N573_RS01070	COG1063	alcohol dehydrogenase
N573_RS01095	COG0778	Nitroreductase
N573_RS01115	COG3973	AAA domain
N573_RS01120	COG0248	Ppx GppA phosphatase
N573_RS01135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N573_RS01145	COG1801	Protein of unknown function DUF72
N573_RS01150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N573_RS01150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N573_RS01155	COG0084	hydrolase, TatD family'
N573_RS01160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
N573_RS01165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N573_RS01170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N573_RS01180	COG1121	(ABC) transporter
N573_RS01185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N573_RS01190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N573_RS01195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N573_RS01200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N573_RS01215	COG1078	dGTPase activity
N573_RS01225	COG3343	RNA polymerase activity
N573_RS01230	COG0504	CTP synthase activity
N573_RS01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N573_RS01240	COG0254	rRNA binding
N573_RS01250	COG3764	Sortase (surface protein transpeptidase)
N573_RS01265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N573_RS01270	COG1704	LemA family
N573_RS01275	COG0501	Belongs to the peptidase M48B family
N573_RS01280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N573_RS01290	COG0736	holo-[acyl-carrier-protein] synthase activity
N573_RS01295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N573_RS01300	COG2337	Toxic component of a toxin-antitoxin (TA) module
N573_RS01310	COG0193	aminoacyl-tRNA hydrolase activity
N573_RS01315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N573_RS01320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N573_RS01330	COG1098	S1 RNA binding domain
N573_RS01335	COG0037	tRNA processing
N573_RS01350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N573_RS01355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N573_RS01360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N573_RS01405	COG3328	transposase activity
N573_RS01435	COG3104	oligopeptide transport
N573_RS01460	COG1794	racemase activity, acting on amino acids and derivatives
N573_RS01465	COG2188	Transcriptional regulator
N573_RS01470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N573_RS01475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N573_RS01480	COG2183	response to ionizing radiation
N573_RS01485	COG3091	SprT-like family
N573_RS01495	COG3250	beta-galactosidase activity
N573_RS01500	COG3250	beta-galactosidase activity
N573_RS01510	COG0588	phosphoglycerate mutase activity
N573_RS01515	COG0657	acetylesterase activity
N573_RS01525	COG0110	maltose O-acetyltransferase activity
N573_RS01540	COG0756	dUTP diphosphatase activity
N573_RS01545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N573_RS01550	COG4956	integral membrane protein (PIN domain superfamily)
N573_RS01555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N573_RS01560	COG4475	Protein of unknown function (DUF436)
N573_RS01565	COG0215	cysteine-tRNA ligase activity
N573_RS01570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
N573_RS01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N573_RS01590	COG0250	Participates in transcription elongation, termination and antitermination
N573_RS01595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N573_RS01600	COG0081	regulation of translation
N573_RS01605	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS01610	COG0531	amino acid
N573_RS01615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N573_RS01620	COG0222	ribosome binding
N573_RS01625	COG1271	oxidase subunit
N573_RS01630	COG1294	oxidase, subunit
N573_RS01635	COG4988	ABC transporter
N573_RS01640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N573_RS01645	COG1012	belongs to the aldehyde dehydrogenase family
N573_RS01645	COG1454	alcohol dehydrogenase
N573_RS01650	COG1114	Component of the transport system for branched-chain amino acids
N573_RS01655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N573_RS01660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N573_RS01665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N573_RS01670	COG0590	tRNA wobble adenosine to inosine editing
N573_RS01675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N573_RS01680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N573_RS01685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N573_RS01695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N573_RS01700	COG3870	Protein conserved in bacteria
N573_RS01705	COG0470	DNA polymerase III
N573_RS01710	COG4467	Involved in initiation control of chromosome replication
N573_RS01730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N573_RS01735	COG0248	Ppx GppA phosphatase
N573_RS01740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N573_RS01750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N573_RS01760	COG2235	arginine
N573_RS01770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N573_RS01775	COG0436	Aminotransferase
N573_RS01780	COG1214	PFAM Peptidase M22, glycoprotease
N573_RS01790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N573_RS01800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N573_RS01805	COG1846	Transcriptional regulator
N573_RS01810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N573_RS01820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N573_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
N573_RS01830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N573_RS01835	COG0511	ligase activity, forming carbon-carbon bonds
N573_RS01850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N573_RS01860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N573_RS01865	COG1268	BioY protein
N573_RS01880	COG0488	(ABC) transporter
N573_RS01885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N573_RS01890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N573_RS01895	COG0459	protein refolding
N573_RS01900	COG0531	amino acid
N573_RS01910	COG1739	Uncharacterized protein family UPF0029
N573_RS01915	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N573_RS01930	COG0653	protein targeting
N573_RS01935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N573_RS01945	COG1950	PFAM Membrane protein of
N573_RS01950	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N573_RS01955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N573_RS01960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N573_RS01970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N573_RS01975	COG0436	Aminotransferase
N573_RS01980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N573_RS01990	COG0675	Transposase, IS605 OrfB family
N573_RS02005	COG2801	Transposase and inactivated derivatives
N573_RS02010	COG0492	ferredoxin-NADP+ reductase activity
N573_RS02015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N573_RS02020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N573_RS02025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N573_RS02035	COG0561	phosphatase activity
N573_RS02040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N573_RS02055	COG0556	nucleotide-excision repair
N573_RS02060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N573_RS02070	COG1660	Displays ATPase and GTPase activities
N573_RS02075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N573_RS02080	COG1481	regulation of sporulation
N573_RS02090	COG0740	serine-type endopeptidase activity
N573_RS02160	COG2801	Transposase and inactivated derivatives
N573_RS02175	COG0126	phosphoglycerate kinase activity
N573_RS02180	COG0149	triose-phosphate isomerase activity
N573_RS02185	COG0148	phosphopyruvate hydratase activity
N573_RS02190	COG1113	amino acid transport
N573_RS02205	COG0557	exoribonuclease II activity
N573_RS02210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N573_RS02220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N573_RS02225	COG0280	phosphate acetyltransferase
N573_RS02230	COG0802	atpase or kinase
N573_RS02240	COG2176	DNA-directed DNA polymerase activity
N573_RS02245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N573_RS02260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N573_RS02265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N573_RS02275	COG2755	lipolytic protein G-D-S-L family
N573_RS02275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N573_RS02280	COG0561	phosphatase activity
N573_RS02285	COG1388	LysM domain
N573_RS02285	COG3942	CHAP domain
N573_RS02290	COG2855	membrane
N573_RS02295	COG0583	DNA-binding transcription factor activity
N573_RS02300	COG1482	cell wall glycoprotein biosynthetic process
N573_RS02305	COG1307	EDD domain protein, DegV family
N573_RS02325	COG3715	PTS system
N573_RS02330	COG3716	PTS system mannose fructose sorbose family IID component
N573_RS02340	COG0745	RESPONSE REGULATOR receiver
N573_RS02345	COG3850	Histidine kinase
N573_RS02345	COG5002	protein histidine kinase activity
N573_RS02350	COG4975	Glucose uptake
N573_RS02360	COG2801	Transposase and inactivated derivatives
N573_RS02370	COG0675	Transposase, IS605 OrfB family
N573_RS02375	COG0450	alkyl hydroperoxide reductase
N573_RS02405	COG0656	L-ascorbic acid biosynthetic process
N573_RS02410	COG0149	triose-phosphate isomerase activity
N573_RS02415	COG3527	Alpha-acetolactate decarboxylase
N573_RS02450	COG1132	(ABC) transporter
N573_RS02455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N573_RS02470	COG3442	glutamine amidotransferase
N573_RS02475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N573_RS02480	COG1435	thymidine kinase activity
N573_RS02485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N573_RS02490	COG2890	protein-(glutamine-N5) methyltransferase activity
N573_RS02495	COG0009	L-threonylcarbamoyladenylate synthase
N573_RS02500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N573_RS02505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N573_RS02520	COG2233	PERMEase
N573_RS02525	COG0356	it plays a direct role in the translocation of protons across the membrane
N573_RS02530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N573_RS02535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N573_RS02540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N573_RS02545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N573_RS02550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N573_RS02555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N573_RS02560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N573_RS02570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N573_RS02575	COG1077	Cell shape determining protein MreB Mrl
N573_RS02585	COG0772	Belongs to the SEDS family
N573_RS02600	COG1181	Belongs to the D-alanine--D-alanine ligase family
N573_RS02610	COG0589	response to stress
N573_RS02620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N573_RS02640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N573_RS02655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N573_RS02660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N573_RS02665	COG1104	cysteine desulfurase activity
N573_RS02670	COG0301	tRNA thio-modification
N573_RS02675	COG2610	gluconate transmembrane transporter activity
N573_RS02680	COG1929	Belongs to the glycerate kinase type-1 family
N573_RS02695	COG2801	Transposase and inactivated derivatives
N573_RS02700	COG3328	transposase activity
N573_RS02730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N573_RS02735	COG0525	valine-tRNA ligase activity
N573_RS02740	COG0285	dihydrofolate synthase activity
N573_RS02760	COG1077	Cell shape determining protein MreB Mrl
N573_RS02765	COG1792	Involved in formation and maintenance of cell shape
N573_RS02775	COG0765	amino acid transport
N573_RS02780	COG1126	abc transporter atp-binding protein
N573_RS02785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS02790	COG0612	Peptidase, M16
N573_RS02795	COG0612	Peptidase, M16
N573_RS02800	COG1426	Protein conserved in bacteria
N573_RS02805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N573_RS02810	COG1058	Belongs to the CinA family
N573_RS02810	COG1546	Belongs to the CinA family
N573_RS02815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N573_RS02825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N573_RS02830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N573_RS02835	COG0632	four-way junction helicase activity
N573_RS02840	COG2255	four-way junction helicase activity
N573_RS02855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N573_RS02860	COG0513	Belongs to the DEAD box helicase family
N573_RS02865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N573_RS02870	COG4472	Bacterial protein of unknown function (DUF965)
N573_RS02875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N573_RS02880	COG3906	Belongs to the UPF0473 family
N573_RS02885	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N573_RS02895	COG1193	negative regulation of DNA recombination
N573_RS02900	COG3118	belongs to the thioredoxin family
N573_RS02915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N573_RS02920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N573_RS02925	COG0622	Phosphoesterase
N573_RS02930	COG0561	phosphatase activity
N573_RS02935	COG0668	transmembrane transport
N573_RS02950	COG0006	proline dipeptidase activity
N573_RS02955	COG1609	Transcriptional regulator
N573_RS02965	COG0217	transcriptional regulatory protein
N573_RS02970	COG1388	LysM domain
N573_RS02970	COG0791	NLP P60 protein
N573_RS02980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N573_RS02990	COG4537	Required for transformation and DNA binding
N573_RS03010	COG0827	DNA restriction-modification system
N573_RS03015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N573_RS03025	COG4470	Protein conserved in bacteria
N573_RS03030	COG0647	UMP catabolic process
N573_RS03040	COG0586	Pfam SNARE associated Golgi protein
N573_RS03160	COG1393	Belongs to the ArsC family
N573_RS03165	COG4862	establishment of competence for transformation
N573_RS03185	COG2357	RelA SpoT domain protein
N573_RS03190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N573_RS03195	COG0564	pseudouridine synthase activity
N573_RS03200	COG2706	6-phosphogluconolactonase activity
N573_RS03205	COG0500	methyltransferase
N573_RS03215	COG1674	ftsk spoiiie
N573_RS03225	COG2001	Belongs to the MraZ family
N573_RS03230	COG0275	rRNA processing
N573_RS03240	COG0768	penicillin binding
N573_RS03245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N573_RS03250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N573_RS03255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N573_RS03265	COG0849	cell division
N573_RS03270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N573_RS03275	COG1799	cell septum assembly
N573_RS03290	COG3599	regulation of cell shape
N573_RS03295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N573_RS03300	COG1278	Cold shock
N573_RS03315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N573_RS03325	COG0482	sulfurtransferase activity
N573_RS03340	COG0406	alpha-ribazole phosphatase activity
N573_RS03350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N573_RS03355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N573_RS03360	COG1393	Belongs to the ArsC family
N573_RS03365	COG1597	lipid kinase activity
N573_RS03370	COG5503	Protein of unknown function (DUF1447)
N573_RS03380	COG0242	peptide deformylase activity
N573_RS03385	COG4476	Belongs to the UPF0223 family
N573_RS03390	COG0483	inositol monophosphate 1-phosphatase activity
N573_RS03395	COG1217	gtp-binding protein TYPA
N573_RS03405	COG4471	UPF0298 protein
N573_RS03410	COG0742	ribosomal rna small subunit methyltransferase
N573_RS03415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N573_RS03420	COG3480	Lon protease (S16) C-terminal proteolytic domain
N573_RS03425	COG1555	photosystem II stabilization
N573_RS03425	COG1596	polysaccharide export
N573_RS03430	COG2131	deaminase
N573_RS03435	COG2333	competence protein COMEC
N573_RS03435	COG0658	competence protein
N573_RS03440	COG1466	dna polymerase III delta subunit
N573_RS03445	COG0268	Binds directly to 16S ribosomal RNA
N573_RS03450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N573_RS03470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N573_RS03475	COG0544	peptidyl-prolyl cis-trans isomerase activity
N573_RS03480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N573_RS03485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N573_RS03495	COG1126	abc transporter atp-binding protein
N573_RS03500	COG0322	excinuclease ABC activity
N573_RS03505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N573_RS03510	COG1234	tRNA 3'-trailer cleavage
N573_RS03515	COG0300	oxidoreductase activity
N573_RS03520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N573_RS03520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N573_RS03525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N573_RS03535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N573_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
N573_RS03570	COG1396	sequence-specific DNA binding
N573_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
N573_RS03605	COG2814	Major facilitator Superfamily
N573_RS03615	COG0367	asparagine synthase
N573_RS03725	COG1393	Belongs to the ArsC family
N573_RS03765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N573_RS03845	COG0640	Transcriptional regulator
N573_RS03850	COG2814	Major facilitator Superfamily
N573_RS03895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N573_RS03950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N573_RS04055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N573_RS04055	COG0551	DNA topoisomerase type I activity
N573_RS04070	COG0542	response to heat
N573_RS04105	COG3764	Sortase (surface protein transpeptidase)
N573_RS04210	COG3328	transposase activity
N573_RS04225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N573_RS04230	COG3328	transposase activity
N573_RS04235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N573_RS04240	COG2226	methyltransferase
N573_RS04255	COG3328	transposase activity
N573_RS04340	COG1061	Type III restriction enzyme res subunit
N573_RS04420	COG2801	Transposase and inactivated derivatives
N573_RS04495	COG1061	Type III restriction enzyme res subunit
N573_RS04565	COG2801	Transposase and inactivated derivatives
N573_RS04585	COG1196	nuclear chromosome segregation
N573_RS04590	COG3253	May function as heme-dependent peroxidase
N573_RS04600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N573_RS04605	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS04630	COG3328	transposase activity
N573_RS04635	COG1136	(ABC) transporter
N573_RS04635	COG0577	efflux transmembrane transporter activity
N573_RS04650	COG1556	Lactate utilization protein
N573_RS04655	COG1139	Iron-sulfur cluster binding protein
N573_RS04660	COG0247	lactate metabolic process
N573_RS04665	COG3425	synthase
N573_RS04670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N573_RS04675	COG4224	UPF0291 protein
N573_RS04680	COG3763	UPF0154 protein
N573_RS04685	COG0204	Acyl-transferase
N573_RS04690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N573_RS04695	COG2827	Endonuclease containing a URI domain
N573_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
N573_RS04705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N573_RS04715	COG0233	cytoplasmic translational termination
N573_RS04720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N573_RS04725	COG4589	Belongs to the CDS family
N573_RS04730	COG0750	zinc metalloprotease
N573_RS04735	COG0442	prolyl-tRNA aminoacylation
N573_RS04740	COG2176	DNA-directed DNA polymerase activity
N573_RS04745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N573_RS04750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N573_RS04755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N573_RS04760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N573_RS04765	COG0505	Belongs to the CarA family
N573_RS04770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N573_RS04775	COG0779	Required for maturation of 30S ribosomal subunits
N573_RS04780	COG0195	Participates in both transcription termination and antitermination
N573_RS04785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N573_RS04795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N573_RS04800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N573_RS04805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N573_RS04810	COG0196	riboflavin kinase activity
N573_RS04815	COG2814	Major facilitator Superfamily
N573_RS04840	COG3328	transposase activity
N573_RS04845	COG2801	Transposase and inactivated derivatives
N573_RS04855	COG0675	Transposase, IS605 OrfB family
N573_RS04870	COG1609	Transcriptional regulator
N573_RS04875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N573_RS04905	COG1192	Involved in chromosome partitioning
N573_RS04915	COG3759	membrane
N573_RS04940	COG2801	Transposase and inactivated derivatives
N573_RS04945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N573_RS04965	COG1420	regulation of RNA biosynthetic process
N573_RS04970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N573_RS04975	COG0443	Heat shock 70 kDa protein
N573_RS04980	COG0484	heat shock protein binding
N573_RS04995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N573_RS05000	COG0140	phosphoribosyl-ATP diphosphatase activity
N573_RS05005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N573_RS05010	COG0481	GTPase activity
N573_RS05020	COG0406	alpha-ribazole phosphatase activity
N573_RS05025	COG0667	Aldo Keto reductase
N573_RS05030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N573_RS05035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N573_RS05050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N573_RS05060	COG0307	riboflavin synthase, alpha
N573_RS05065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N573_RS05065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N573_RS05075	COG5002	protein histidine kinase activity
N573_RS05080	COG0745	RESPONSE REGULATOR receiver
N573_RS05090	COG1104	cysteine desulfurase activity
N573_RS05110	COG1811	Na channel or pump
N573_RS05115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N573_RS05120	COG1464	Belongs to the NlpA lipoprotein family
N573_RS05125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N573_RS05140	COG0351	phosphomethylpyrimidine kinase
N573_RS05145	COG0352	thiamine-phosphate diphosphorylase activity
N573_RS05150	COG0351	phosphomethylpyrimidine kinase
N573_RS05155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N573_RS05170	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS05175	COG1518	maintenance of DNA repeat elements
N573_RS05210	COG0039	L-malate dehydrogenase activity
N573_RS05225	COG2264	protein methyltransferase activity
N573_RS05230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N573_RS05240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N573_RS05245	COG1490	D-aminoacyl-tRNA deacylase activity
N573_RS05255	COG0626	cystathionine gamma-synthase activity
N573_RS05260	COG0626	cystathionine gamma-synthase activity
N573_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS05270	COG0456	acetyltransferase
N573_RS05275	COG0765	amino acid transport
N573_RS05280	COG1126	abc transporter atp-binding protein
N573_RS05285	COG1473	amidohydrolase
N573_RS05290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N573_RS05295	COG2079	MmgE PrpD family protein
N573_RS05300	COG0765	amino acid transport
N573_RS05305	COG0765	amino acid transport
N573_RS05310	COG1126	abc transporter atp-binding protein
N573_RS05325	COG0460	homoserine dehydrogenase
N573_RS05330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N573_RS05335	COG0833	amino acid
N573_RS05340	COG2040	homocysteine
N573_RS05345	COG3001	Fructosamine kinase
N573_RS05350	COG0860	N-Acetylmuramoyl-L-alanine amidase
N573_RS05360	COG0124	histidyl-tRNA synthetase
N573_RS05365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N573_RS05375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N573_RS05380	COG1610	YqeY-like protein
N573_RS05385	COG1702	phosphate starvation-inducible protein PhoH
N573_RS05390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N573_RS05395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N573_RS05400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N573_RS05405	COG1381	Involved in DNA repair and RecF pathway recombination
N573_RS05410	COG0752	glycyl-tRNA synthetase alpha subunit
N573_RS05415	COG0751	glycine-tRNA ligase activity
N573_RS05420	COG0358	DNA primase activity
N573_RS05425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N573_RS05430	COG2801	Transposase and inactivated derivatives
N573_RS05455	COG2261	transglycosylase associated protein
N573_RS05460	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS05480	COG0527	aspartate kinase activity
N573_RS05485	COG0019	diaminopimelate decarboxylase activity
N573_RS05490	COG2171	N-acyltransferase activity
N573_RS05495	COG1473	amidohydrolase
N573_RS05500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N573_RS05505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N573_RS05510	COG0436	Aminotransferase
N573_RS05515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N573_RS05520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N573_RS05525	COG0569	domain protein
N573_RS05530	COG2384	SAM-dependent methyltransferase
N573_RS05535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N573_RS05540	COG2195	Cleaves the N-terminal amino acid of tripeptides
N573_RS05550	COG0587	DNA-directed DNA polymerase activity
N573_RS05575	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N573_RS05580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N573_RS05585	COG1187	pseudouridine synthase activity
N573_RS05590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N573_RS05600	COG0514	ATP-dependent DNA helicase (RecQ)
N573_RS05610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N573_RS05615	COG0539	negative regulation of cytoplasmic translation
N573_RS05620	COG1160	GTP binding
N573_RS05630	COG0457	Tetratricopeptide repeat
N573_RS05640	COG0617	tRNA 3'-terminal CCA addition
N573_RS05645	COG0488	(ABC) transporter
N573_RS05650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N573_RS05655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N573_RS05660	COG1272	protein, Hemolysin III
N573_RS05665	COG1307	EDD domain protein, DegV family
N573_RS05670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N573_RS05680	COG2755	lipolytic protein G-D-S-L family
N573_RS05685	COG4698	Protein conserved in bacteria
N573_RS05690	COG4479	Belongs to the UPF0346 family
N573_RS05695	COG3328	transposase activity
N573_RS05720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N573_RS05765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N573_RS05790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N573_RS05795	COG0187	DNA topoisomerase II activity
N573_RS05800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N573_RS05820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N573_RS05830	COG1956	GAF domain-containing protein
N573_RS05840	COG0402	S-adenosylhomocysteine deaminase activity
N573_RS05855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N573_RS05860	COG1811	Na channel or pump
N573_RS05865	COG2223	nitrite transmembrane transporter activity
N573_RS05875	COG2814	Major facilitator Superfamily
N573_RS05905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N573_RS05910	COG0110	maltose O-acetyltransferase activity
N573_RS05915	COG0110	maltose O-acetyltransferase activity
N573_RS05925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N573_RS05935	COG2423	ornithine cyclodeaminase activity
N573_RS05975	COG0656	L-ascorbic acid biosynthetic process
N573_RS05980	COG4720	Psort location CytoplasmicMembrane, score
N573_RS05990	COG0538	isocitrate dehydrogenase activity
N573_RS06000	COG4974	Belongs to the 'phage' integrase family
N573_RS06005	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
N573_RS06010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N573_RS06025	COG1063	alcohol dehydrogenase
N573_RS06050	COG1732	Glycine betaine
N573_RS06120	COG4975	Glucose uptake
N573_RS06125	COG1609	Transcriptional regulator
N573_RS06130	COG2801	Transposase and inactivated derivatives
N573_RS06210	COG0318	PFAM AMP-dependent synthetase and ligase
N573_RS06215	COG2271	Major facilitator Superfamily
N573_RS06225	COG0626	cystathionine gamma-synthase activity
N573_RS06230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N573_RS06240	COG2848	UPF0210 protein
N573_RS06275	COG0697	spore germination
N573_RS06285	COG1053	succinate dehydrogenase
N573_RS06285	COG3976	FMN-binding domain protein
N573_RS06290	COG0583	DNA-binding transcription factor activity
N573_RS06300	COG0183	Belongs to the thiolase family
N573_RS06305	COG0628	permease
N573_RS06310	COG0730	response to heat
N573_RS06315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N573_RS06320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N573_RS06345	COG1250	3-hydroxyacyl-CoA dehydrogenase
N573_RS06365	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS06370	COG1113	amino acid transport
N573_RS06380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N573_RS06400	COG0105	UTP biosynthetic process
N573_RS06405	COG1695	Transcriptional regulator
N573_RS06410	COG3479	Phenolic acid decarboxylase
N573_RS06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS06435	COG2918	glutathione biosynthetic process
N573_RS06435	COG1181	Belongs to the D-alanine--D-alanine ligase family
N573_RS06440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N573_RS06445	COG0402	S-adenosylhomocysteine deaminase activity
N573_RS06450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N573_RS06480	COG2801	Transposase and inactivated derivatives
N573_RS06490	COG0390	transport system, permease component
N573_RS06500	COG0028	Belongs to the TPP enzyme family
N573_RS06535	COG1263	PTS System
N573_RS06535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N573_RS06535	COG2190	(PTS) system
N573_RS06540	COG2188	Transcriptional regulator
N573_RS06545	COG0366	Alpha amylase catalytic
N573_RS06565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N573_RS06610	COG0582	viral genome integration into host DNA
N573_RS06630	COG2801	Transposase and inactivated derivatives
N573_RS06635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N573_RS06645	COG1397	ADP-ribosylglycohydrolase
N573_RS06675	COG2610	gluconate transmembrane transporter activity
N573_RS06680	COG1609	Transcriptional regulator
N573_RS06690	COG0436	Aminotransferase
N573_RS06735	COG2181	nitrate reductase activity
N573_RS06745	COG1140	nitrate reductase beta subunit
N573_RS06750	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
N573_RS06770	COG0315	cyclic pyranopterin monophosphate synthase activity
N573_RS06795	COG2197	response regulator
N573_RS06820	COG2226	methyltransferase
N573_RS06830	COG2151	metal-sulfur cluster biosynthetic enzyme
N573_RS06835	COG2223	nitrite transmembrane transporter activity
N573_RS06840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N573_RS06860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N573_RS06865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N573_RS06870	COG1252	NADH dehydrogenase
N573_RS06875	COG2151	metal-sulfur cluster biosynthetic enzyme
N573_RS06895	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS06905	COG0719	Fe-S assembly protein
N573_RS06910	COG0822	iron-sulfur transferase activity
N573_RS06915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N573_RS06920	COG0719	Fe-S assembly protein
N573_RS06950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N573_RS06955	COG0436	Aminotransferase
N573_RS06960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N573_RS06965	COG0287	Prephenate dehydrogenase
N573_RS06970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N573_RS06980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N573_RS06985	COG1605	Chorismate mutase
N573_RS06985	COG0077	Prephenate dehydratase
N573_RS06990	COG0738	Major facilitator superfamily
N573_RS06995	COG3104	oligopeptide transport
N573_RS07005	COG0561	phosphatase activity
N573_RS07025	COG0477	Major facilitator Superfamily
N573_RS07065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N573_RS07070	COG1942	4-Oxalocrotonate Tautomerase
N573_RS07075	COG0569	domain protein
N573_RS07075	COG0475	glutathione-regulated potassium exporter activity
N573_RS07090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N573_RS07095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N573_RS07105	COG0477	Major facilitator Superfamily
N573_RS07115	COG1253	flavin adenine dinucleotide binding
N573_RS07120	COG2814	Major facilitator Superfamily
N573_RS07130	COG0583	DNA-binding transcription factor activity
N573_RS07140	COG0095	Lipoate-protein ligase
N573_RS07170	COG1687	branched-chain amino acid
N573_RS07185	COG0460	homoserine dehydrogenase
N573_RS07190	COG0083	homoserine kinase activity
N573_RS07200	COG0702	epimerase
N573_RS07205	COG1418	mRNA catabolic process
N573_RS07210	COG3022	response to hydroperoxide
N573_RS07220	COG1307	EDD domain protein, DegV family
N573_RS07225	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N573_RS07235	COG3328	transposase activity
N573_RS07245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N573_RS07250	COG0505	Belongs to the CarA family
N573_RS07255	COG0564	pseudouridine synthase activity
N573_RS07270	COG0328	RNA-DNA hybrid ribonuclease activity
N573_RS07280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS07285	COG0765	amino acid transport
N573_RS07305	COG0154	amidase activity
N573_RS07315	COG0116	Belongs to the methyltransferase superfamily
N573_RS07320	COG1051	belongs to the nudix hydrolase family
N573_RS07335	COG3599	regulation of cell shape
N573_RS07340	COG4474	Belongs to the UPF0398 family
N573_RS07345	COG3331	DNA recombination
N573_RS07355	COG0697	spore germination
N573_RS07360	COG0667	Aldo Keto reductase
N573_RS07385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N573_RS07385	COG1199	ATP-dependent helicase activity
N573_RS07410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N573_RS07415	COG0581	inorganic phosphate transmembrane transporter activity
N573_RS07420	COG0573	inorganic phosphate transmembrane transporter activity
N573_RS07430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N573_RS07430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N573_RS07435	COG0561	phosphatase activity
N573_RS07440	COG0167	dihydroorotate dehydrogenase activity
N573_RS07445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N573_RS07450	COG0505	Belongs to the CarA family
N573_RS07455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N573_RS07465	COG4336	lyase activity
N573_RS07475	COG2801	Transposase and inactivated derivatives
N573_RS07480	COG2801	Transposase and inactivated derivatives
N573_RS07490	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
N573_RS07495	COG1518	maintenance of DNA repeat elements
N573_RS07535	COG0335	large ribosomal subunit rRNA binding
N573_RS07540	COG0531	amino acid
N573_RS07545	COG0336	Belongs to the RNA methyltransferase TrmD family
N573_RS07550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N573_RS07555	COG1837	Belongs to the UPF0109 family
N573_RS07560	COG0228	four-way junction DNA binding
N573_RS07570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N573_RS07575	COG0581	inorganic phosphate transmembrane transporter activity
N573_RS07580	COG0573	inorganic phosphate transmembrane transporter activity
N573_RS07585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N573_RS07590	COG0745	RESPONSE REGULATOR receiver
N573_RS07605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N573_RS07610	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
N573_RS07615	COG0552	protein localization to endoplasmic reticulum
N573_RS07620	COG1196	nuclear chromosome segregation
N573_RS07625	COG0571	ribonuclease III activity
N573_RS07630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N573_RS07635	COG0416	fatty acid biosynthetic process
N573_RS07640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N573_RS07645	COG1461	Dihydroxyacetone kinase
N573_RS07655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N573_RS07660	COG1564	THIamine pyrophosphokinase
N573_RS07665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N573_RS07670	COG1162	GTPase activity
N573_RS07675	COG0515	serine threonine protein kinase
N573_RS07675	COG2815	serine threonine protein kinase
N573_RS07685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N573_RS07685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N573_RS07690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N573_RS07695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N573_RS07700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N573_RS07705	COG1758	RNA polymerase activity
N573_RS07720	COG2826	transposase and inactivated derivatives, IS30 family
N573_RS07725	COG0497	DNA recombination
N573_RS07730	COG1438	arginine binding
N573_RS07735	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N573_RS07750	COG1570	exodeoxyribonuclease VII activity
N573_RS07755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N573_RS07760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N573_RS07765	COG1302	Protein conserved in bacteria
N573_RS07770	COG0006	proline dipeptidase activity
N573_RS07775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N573_RS07785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N573_RS07790	COG1309	transcriptional regulator
N573_RS07805	COG1388	LysM domain
N573_RS07805	COG3942	CHAP domain
N573_RS07970	COG0629	single-stranded DNA binding
N573_RS08005	COG3646	Phage regulatory protein
N573_RS08005	COG3645	SOS response
N573_RS08015	COG1396	sequence-specific DNA binding
N573_RS08065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N573_RS08075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N573_RS08080	COG1940	carbohydrate kinase activity
N573_RS08095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N573_RS08100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N573_RS08105	COG0768	penicillin binding
N573_RS08115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N573_RS08120	COG0572	uridine kinase
N573_RS08125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N573_RS08125	COG0072	phenylalanine-tRNA ligase activity
N573_RS08130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N573_RS08135	COG1733	regulation of RNA biosynthetic process
N573_RS08145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N573_RS08150	COG1254	Belongs to the acylphosphatase family
N573_RS08155	COG0706	membrane insertase activity
N573_RS08160	COG0242	peptide deformylase activity
N573_RS08170	COG5002	protein histidine kinase activity
N573_RS08175	COG0745	RESPONSE REGULATOR receiver
N573_RS08180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N573_RS08190	COG1323	Belongs to the UPF0348 family
N573_RS08195	COG2226	methyltransferase
N573_RS08200	COG0799	negative regulation of ribosome biogenesis
N573_RS08210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N573_RS08220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N573_RS08240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N573_RS08245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N573_RS08250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N573_RS08255	COG1484	DNA-dependent DNA replication
N573_RS08265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N573_RS08270	COG0237	dephospho-CoA kinase activity
N573_RS08275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N573_RS08290	COG0670	Belongs to the BI1 family
N573_RS08295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N573_RS08300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N573_RS08305	COG3118	belongs to the thioredoxin family
N573_RS08315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N573_RS08325	COG1131	(ABC) transporter
N573_RS08330	COG0537	adenosine 5'-monophosphoramidase activity
N573_RS08345	COG3481	metal-dependent phosphohydrolase, HD sub domain
N573_RS08350	COG3679	Belongs to the UPF0342 family
N573_RS08355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N573_RS08360	COG0018	arginyl-trna synthetase
N573_RS08380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N573_RS08385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N573_RS08395	COG0302	gtp cyclohydrolase
N573_RS08400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N573_RS08400	COG0302	gtp cyclohydrolase
N573_RS08415	COG1609	Transcriptional regulator
N573_RS08425	COG1428	Deoxynucleoside kinase
N573_RS08430	COG1388	LysM domain
N573_RS08430	COG1705	Flagellar rod assembly protein muramidase FlgJ
N573_RS08440	COG0589	response to stress
N573_RS08445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N573_RS08450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N573_RS08460	COG2244	polysaccharide biosynthetic process
N573_RS08470	COG0495	leucyl-tRNA aminoacylation
N573_RS08475	COG0671	phosphoesterase, PA-phosphatase related
N573_RS08480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N573_RS08485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N573_RS08490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N573_RS08500	COG2818	Glycosylase
N573_RS08505	COG2814	Major facilitator Superfamily
N573_RS08515	COG1113	amino acid transport
N573_RS08550	COG1607	acyl-coa hydrolase
N573_RS08570	COG2233	PERMEase
N573_RS08580	COG0602	queuosine metabolic process
N573_RS08590	COG0765	amino acid transport
N573_RS08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS08600	COG2076	Multidrug Resistance protein
N573_RS08695	COG0438	transferase activity, transferring glycosyl groups
N573_RS08700	COG0438	transferase activity, transferring glycosyl groups
N573_RS08705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N573_RS08720	COG0542	response to heat
N573_RS08730	COG1335	isochorismatase
N573_RS08735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N573_RS08750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N573_RS08770	COG1131	(ABC) transporter
N573_RS08775	COG2188	Transcriptional regulator
N573_RS08780	COG1088	dTDP-glucose 4,6-dehydratase activity
N573_RS08790	COG1216	Glycosyl transferase, family 2
N573_RS08800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N573_RS08815	COG0463	Glycosyl transferase, family 2
N573_RS08830	COG2801	Transposase and inactivated derivatives
N573_RS08855	COG3328	transposase activity
N573_RS08865	COG2801	Transposase and inactivated derivatives
N573_RS08875	COG0628	permease
N573_RS08880	COG0463	Glycosyl transferase, family 2
N573_RS08900	COG1705	Flagellar rod assembly protein muramidase FlgJ
N573_RS08910	COG0438	transferase activity, transferring glycosyl groups
N573_RS08920	COG0562	UDP-galactopyranose mutase
N573_RS08935	COG0438	transferase activity, transferring glycosyl groups
N573_RS08960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N573_RS08980	COG1295	ribonuclease BN
N573_RS08985	COG1368	sulfuric ester hydrolase activity
N573_RS09005	COG0024	Methionine aminopeptidase
N573_RS09010	COG0716	FMN binding
N573_RS09015	COG2246	polysaccharide biosynthetic process
N573_RS09025	COG0513	Belongs to the DEAD box helicase family
N573_RS09050	COG2918	glutathione biosynthetic process
N573_RS09060	COG4841	protein insertion into membrane
N573_RS09065	COG0488	(ABC) transporter
N573_RS09070	COG0783	Belongs to the Dps family
N573_RS09080	COG1316	TRANSCRIPTIONal
N573_RS09085	COG1846	Transcriptional regulator
N573_RS09095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N573_RS09110	COG2226	methyltransferase
N573_RS09130	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
N573_RS09140	COG1757	Na H antiporter
N573_RS09175	COG0446	pyridine nucleotide-disulphide oxidoreductase
N573_RS09180	COG3328	transposase activity
N573_RS09200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N573_RS09275	COG4626	Terminase
N573_RS09275	COG1802	Transcriptional regulator
N573_RS09280	COG4695	Portal protein
N573_RS09285	COG0740	serine-type endopeptidase activity
N573_RS09350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N573_RS09355	COG1597	lipid kinase activity
N573_RS09360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N573_RS09365	COG0154	amidase activity
N573_RS09370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N573_RS09375	COG4851	CamS sex pheromone cAM373 precursor
N573_RS09380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N573_RS09395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N573_RS09400	COG1705	Flagellar rod assembly protein muramidase FlgJ
N573_RS09415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N573_RS09420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N573_RS09425	COG0101	tRNA pseudouridine synthase activity
N573_RS09435	COG1122	ATPase activity
N573_RS09440	COG1122	ATPase activity
N573_RS09445	COG0203	ribosomal protein L17
N573_RS09450	COG0202	RNA polymerase activity
N573_RS09455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N573_RS09460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N573_RS09465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N573_RS09470	COG0563	adenylate kinase activity
N573_RS09480	COG0200	Binds to the 23S rRNA
N573_RS09485	COG1841	ribosomal large subunit assembly
N573_RS09490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N573_RS09495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N573_RS09500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N573_RS09505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N573_RS09510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N573_RS09515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N573_RS09520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N573_RS09525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N573_RS09535	COG0255	Belongs to the universal ribosomal protein uL29 family
N573_RS09540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N573_RS09545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N573_RS09550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N573_RS09555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N573_RS09560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N573_RS09565	COG0089	rRNA binding
N573_RS09570	COG0088	Forms part of the polypeptide exit tunnel
N573_RS09575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N573_RS09580	COG0051	transcription antitermination factor activity, RNA binding
N573_RS09585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N573_RS09590	COG0049	tRNA binding
N573_RS09595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N573_RS09600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N573_RS09610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N573_RS09620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N573_RS09625	COG0085	RNA polymerase activity
N573_RS09635	COG0542	response to heat
N573_RS09640	COG4463	regulation of RNA biosynthetic process
N573_RS09645	COG1064	alcohol dehydrogenase
N573_RS09665	COG1968	undecaprenyl-diphosphatase activity
N573_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
N573_RS09700	COG1428	Deoxynucleoside kinase
N573_RS09705	COG0833	amino acid
N573_RS09735	COG1278	Cold shock
N573_RS09795	COG2814	Major facilitator Superfamily
N573_RS09805	COG2160	L-arabinose isomerase activity
N573_RS09810	COG0564	pseudouridine synthase activity
N573_RS09820	COG0392	lysyltransferase activity
N573_RS09820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N573_RS09825	COG0693	protein deglycase activity
N573_RS09830	COG0657	acetylesterase activity
N573_RS09850	COG2267	carboxylic ester hydrolase activity
N573_RS09870	COG3052	prosthetic group binding
N573_RS09880	COG0281	malic enzyme
N573_RS09890	COG0471	metal ion transport
N573_RS09895	COG0039	L-malate dehydrogenase activity
N573_RS09900	COG1053	succinate dehydrogenase
N573_RS09905	COG0114	fumarate hydratase activity
N573_RS09910	COG0431	NADPH-dependent FMN reductase
N573_RS09910	COG1053	succinate dehydrogenase
N573_RS09910	COG3976	FMN-binding domain protein
N573_RS09915	COG0431	NADPH-dependent FMN reductase
N573_RS09915	COG3976	FMN-binding domain protein
N573_RS09915	COG1053	succinate dehydrogenase
N573_RS09920	COG0281	malic enzyme
N573_RS09925	COG0583	DNA-binding transcription factor activity
N573_RS09945	COG2190	(PTS) system
N573_RS09945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N573_RS09945	COG1263	PTS System
N573_RS09965	COG0583	DNA-binding transcription factor activity
N573_RS09970	COG2326	polyphosphate kinase activity
N573_RS09990	COG1686	Belongs to the peptidase S11 family
N573_RS10000	COG2706	6-phosphogluconolactonase activity
N573_RS10020	COG0494	nUDIX hydrolase
N573_RS10030	COG2814	Major facilitator Superfamily
N573_RS10055	COG2801	Transposase and inactivated derivatives
N573_RS10065	COG1854	S-ribosylhomocysteine lyase activity
N573_RS10070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N573_RS10080	COG2502	aspartate--ammonia ligase
N573_RS10095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N573_RS10105	COG0789	Transcriptional regulator
N573_RS10110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N573_RS10115	COG1984	allophanate hydrolase subunit 2
N573_RS10125	COG0439	Biotin carboxylase
N573_RS10130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N573_RS10135	COG1914	H( )-stimulated, divalent metal cation uptake system
N573_RS10150	COG0675	Transposase, IS605 OrfB family
N573_RS10160	COG3118	belongs to the thioredoxin family
N573_RS10190	COG0531	amino acid
N573_RS10210	COG0165	Argininosuccinate lyase
N573_RS10235	COG1136	(ABC) transporter
N573_RS10245	COG1136	(ABC) transporter
N573_RS10245	COG0577	efflux transmembrane transporter activity
N573_RS10255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N573_RS10260	COG0393	Putative heavy-metal-binding
N573_RS10270	COG2070	2-Nitropropane dioxygenase
N573_RS10275	COG0640	Transcriptional regulator
N573_RS10290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N573_RS10300	COG0519	Catalyzes the synthesis of GMP from XMP
N573_RS10305	COG2357	RelA SpoT domain protein
N573_RS10310	COG0745	RESPONSE REGULATOR receiver
N573_RS10315	COG5002	protein histidine kinase activity
N573_RS10320	COG1072	(Pantothenic acid kinase))
N573_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
N573_RS10335	COG1368	sulfuric ester hydrolase activity
N573_RS10345	COG3973	AAA domain
N573_RS10350	COG0586	Pfam SNARE associated Golgi protein
N573_RS10360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N573_RS10365	COG4948	Mandelate Racemase Muconate Lactonizing
N573_RS10375	COG0531	amino acid
N573_RS10390	COG1511	domain protein
N573_RS10400	COG2017	converts alpha-aldose to the beta-anomer
N573_RS10415	COG0735	belongs to the Fur family
N573_RS10420	COG0194	GDP metabolic process
N573_RS10430	COG0531	amino acid
N573_RS10435	COG2936	dipeptidyl-peptidase activity
N573_RS10440	COG0675	Transposase, IS605 OrfB family
N573_RS10465	COG2267	carboxylic ester hydrolase activity
N573_RS10480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N573_RS10485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N573_RS10490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N573_RS10500	COG1376	ErfK ybiS ycfS ynhG family protein
N573_RS10510	COG0488	(ABC) transporter
N573_RS10520	COG4120	Belongs to the binding-protein-dependent transport system permease family
N573_RS10525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N573_RS10535	COG0004	ammonium transporteR
N573_RS10545	COG1940	carbohydrate kinase activity
N573_RS10555	COG1609	Transcriptional regulator
N573_RS10560	COG2084	Dehydrogenase
N573_RS10570	COG3118	belongs to the thioredoxin family
N573_RS10575	COG0861	Integral membrane protein TerC family
N573_RS10580	COG0564	pseudouridine synthase activity
N573_RS10590	COG2233	PERMEase
N573_RS10605	COG0702	epimerase
N573_RS10610	COG0406	alpha-ribazole phosphatase activity
N573_RS10615	COG1368	sulfuric ester hydrolase activity
N573_RS10625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N573_RS10635	COG2217	Heavy metal translocating P-type atpase
N573_RS10640	COG2217	Heavy metal translocating P-type atpase
N573_RS10645	COG0492	ferredoxin-NADP+ reductase activity
N573_RS10650	COG1957	nucleoside hydrolase
N573_RS10660	COG1122	ATPase activity
N573_RS10680	COG0095	Lipoate-protein ligase
N573_RS10695	COG1396	sequence-specific DNA binding
N573_RS10715	COG0589	response to stress
N573_RS10740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N573_RS10745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N573_RS10750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N573_RS10765	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N573_RS10770	COG1606	tRNA processing
N573_RS10775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N573_RS10780	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
N573_RS10785	COG1691	(AIR) carboxylase
N573_RS10790	COG3875	lactate racemase activity
N573_RS10795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N573_RS10830	COG1869	D-ribose catabolic process
N573_RS10840	COG2390	Transcriptional regulator
N573_RS10850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N573_RS10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N573_RS10865	COG3775	system Galactitol-specific IIC component
N573_RS10870	COG1609	Transcriptional regulator
N573_RS10895	COG0561	phosphatase activity
N573_RS10900	COG2188	Transcriptional regulator
N573_RS10905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N573_RS10935	COG1253	flavin adenine dinucleotide binding
N573_RS10950	COG2807	transmembrane transport
N573_RS10960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N573_RS10965	COG0589	response to stress
N573_RS10970	COG1522	sequence-specific DNA binding
N573_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
N573_RS10980	COG1609	Transcriptional regulator
N573_RS10985	COG1164	Oligoendopeptidase f
N573_RS10990	COG1301	dicarboxylic acid transport
N573_RS11010	COG0277	FAD linked oxidase domain protein
N573_RS11020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N573_RS11020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N573_RS11095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N573_RS11095	COG0551	DNA topoisomerase type I activity
N573_RS11140	COG0577	efflux transmembrane transporter activity
N573_RS11170	COG1609	Transcriptional regulator
N573_RS11175	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
N573_RS11180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N573_RS11190	COG2365	Tyrosine phosphatase family
N573_RS11195	COG1881	PFAM PEBP family protein
N573_RS11205	COG1126	abc transporter atp-binding protein
N573_RS11210	COG0765	amino acid transport
N573_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N573_RS11225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N573_RS11230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N573_RS11240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N573_RS11245	COG3590	peptidase
N573_RS11250	COG2252	PERMEase
N573_RS11275	COG3189	MarR family transcriptional regulator
N573_RS11285	COG2249	NAD(P)H dehydrogenase (quinone) activity
N573_RS11295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N573_RS11300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N573_RS11315	COG1609	Transcriptional regulator
N573_RS11320	COG1705	Flagellar rod assembly protein muramidase FlgJ
N573_RS11320	COG1388	LysM domain
N573_RS11325	COG0640	Transcriptional regulator
N573_RS11355	COG3328	transposase activity
N573_RS11365	COG1914	H( )-stimulated, divalent metal cation uptake system
N573_RS11375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N573_RS11400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N573_RS11405	COG0367	asparagine synthase
N573_RS11410	COG0833	amino acid
N573_RS11415	COG1970	mechanosensitive ion channel activity
N573_RS11420	COG0445	tRNA wobble uridine modification
N573_RS11425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N573_RS11435	COG0706	membrane insertase activity
N573_RS11440	COG0594	ribonuclease P activity
N573_RS11490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N573_RS11615	COG1131	(ABC) transporter
N573_RS11625	COG1216	Glycosyl transferase, family 2
N573_RS11660	COG2814	Major facilitator Superfamily
N573_RS11750	COG0657	acetylesterase activity
N573_RS11760	COG2814	Major facilitator Superfamily
N573_RS11780	COG1288	antiporter activity
N573_RS11810	COG0791	NLP P60 protein