locus-tag	class	description
HCY95_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCY95_RS00010	COG0592	DNA-directed DNA polymerase activity
HCY95_RS00015	COG2501	S4 domain
HCY95_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCY95_RS00025	COG0187	DNA topoisomerase II activity
HCY95_RS00045	COG0360	Binds together with S18 to 16S ribosomal RNA
HCY95_RS00050	COG0629	single-stranded DNA binding
HCY95_RS00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCY95_RS00065	COG0359	binds to the 23S rRNA
HCY95_RS00070	COG0305	Participates in initiation and elongation during chromosome replication
HCY95_RS00095	COG0745	RESPONSE REGULATOR receiver
HCY95_RS00115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCY95_RS00120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCY95_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCY95_RS00130	COG1959	2 iron, 2 sulfur cluster binding
HCY95_RS00135	COG1609	Transcriptional regulator
HCY95_RS00150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCY95_RS00175	COG0436	Aminotransferase
HCY95_RS00195	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HCY95_RS00200	COG1074	ATP-dependent DNA helicase activity
HCY95_RS00205	COG0656	L-ascorbic acid biosynthetic process
HCY95_RS00240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCY95_RS00245	COG1012	belongs to the aldehyde dehydrogenase family
HCY95_RS00250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCY95_RS00255	COG0284	orotidine-5'-phosphate decarboxylase activity
HCY95_RS00260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCY95_RS00280	COG0438	transferase activity, transferring glycosyl groups
HCY95_RS00310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCY95_RS00320	COG0667	Aldo Keto reductase
HCY95_RS00325	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCY95_RS00335	COG1696	Membrane protein involved in D-alanine export
HCY95_RS00340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCY95_RS00350	COG0420	3'-5' exonuclease activity
HCY95_RS00355	COG0419	ATPase involved in DNA repair
HCY95_RS00360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCY95_RS00370	COG0675	Transposase, IS605 OrfB family
HCY95_RS00375	COG0501	Belongs to the peptidase M48B family
HCY95_RS00400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCY95_RS00405	COG0765	amino acid transport
HCY95_RS00415	COG1113	amino acid transport
HCY95_RS00430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCY95_RS00460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCY95_RS00470	COG0357	Ribosomal RNA small subunit methyltransferase G
HCY95_RS00480	COG1475	DNA binding
HCY95_RS00485	COG4481	Protein conserved in bacteria
HCY95_RS00490	COG0012	GTP binding
HCY95_RS00500	COG0517	IMP dehydrogenase activity
HCY95_RS00500	COG0516	GMP reductase activity
HCY95_RS00505	COG1316	TRANSCRIPTIONal
HCY95_RS00515	COG0489	protein tyrosine kinase activity
HCY95_RS00520	COG4464	protein tyrosine phosphatase activity
HCY95_RS00525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCY95_RS00530	COG1216	Glycosyl transferase, family 2
HCY95_RS00535	COG2801	Transposase and inactivated derivatives
HCY95_RS00545	COG0438	transferase activity, transferring glycosyl groups
HCY95_RS00560	COG2801	Transposase and inactivated derivatives
HCY95_RS00570	COG2244	polysaccharide biosynthetic process
HCY95_RS00580	COG1216	Glycosyl transferase, family 2
HCY95_RS00580	COG1442	glycosyl transferase family 8
HCY95_RS00590	COG3328	transposase activity
HCY95_RS00620	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS00645	COG2801	Transposase and inactivated derivatives
HCY95_RS00655	COG0745	RESPONSE REGULATOR receiver
HCY95_RS00660	COG5002	protein histidine kinase activity
HCY95_RS00665	COG1686	Belongs to the peptidase S11 family
HCY95_RS00685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCY95_RS00690	COG0675	Transposase, IS605 OrfB family
HCY95_RS00700	COG0628	permease
HCY95_RS00705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HCY95_RS00710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCY95_RS00715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCY95_RS00720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCY95_RS00735	COG1472	Belongs to the glycosyl hydrolase 3 family
HCY95_RS00740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCY95_RS00745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCY95_RS00750	COG0047	phosphoribosylformylglycinamidine synthase activity
HCY95_RS00755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCY95_RS00765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCY95_RS00770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCY95_RS00775	COG0138	bifunctional purine biosynthesis protein purh
HCY95_RS00780	COG0151	Belongs to the GarS family
HCY95_RS00795	COG0588	phosphoglycerate mutase activity
HCY95_RS00800	COG0436	Aminotransferase
HCY95_RS00825	COG0477	Major facilitator Superfamily
HCY95_RS00860	COG0675	Transposase, IS605 OrfB family
HCY95_RS00885	COG4221	oxidoreductase activity
HCY95_RS00900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCY95_RS00905	COG1942	4-Oxalocrotonate Tautomerase
HCY95_RS00920	COG1609	Transcriptional regulator
HCY95_RS00945	COG3328	transposase activity
HCY95_RS00955	COG0675	Transposase, IS605 OrfB family
HCY95_RS00965	COG0697	spore germination
HCY95_RS01000	COG1120	ATPase activity
HCY95_RS01005	COG0477	Major facilitator Superfamily
HCY95_RS01020	COG0708	Exodeoxyribonuclease III
HCY95_RS01055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCY95_RS01100	COG1063	alcohol dehydrogenase
HCY95_RS01120	COG0778	Nitroreductase
HCY95_RS01130	COG1464	Belongs to the NlpA lipoprotein family
HCY95_RS01140	COG3973	AAA domain
HCY95_RS01145	COG0248	Ppx GppA phosphatase
HCY95_RS01160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCY95_RS01170	COG1801	Protein of unknown function DUF72
HCY95_RS01175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCY95_RS01175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCY95_RS01180	COG0084	hydrolase, TatD family'
HCY95_RS01185	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCY95_RS01190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCY95_RS01195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCY95_RS01200	COG0675	Transposase, IS605 OrfB family
HCY95_RS01215	COG1121	(ABC) transporter
HCY95_RS01220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCY95_RS01225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCY95_RS01230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCY95_RS01235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCY95_RS01245	COG0561	phosphatase activity
HCY95_RS01250	COG1078	dGTPase activity
HCY95_RS01260	COG3343	RNA polymerase activity
HCY95_RS01265	COG0504	CTP synthase activity
HCY95_RS01270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCY95_RS01275	COG0254	rRNA binding
HCY95_RS01285	COG3764	Sortase (surface protein transpeptidase)
HCY95_RS01290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCY95_RS01295	COG1704	LemA family
HCY95_RS01300	COG0501	Belongs to the peptidase M48B family
HCY95_RS01305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCY95_RS01315	COG0736	holo-[acyl-carrier-protein] synthase activity
HCY95_RS01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCY95_RS01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCY95_RS01335	COG0193	aminoacyl-tRNA hydrolase activity
HCY95_RS01340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCY95_RS01345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCY95_RS01355	COG1098	S1 RNA binding domain
HCY95_RS01360	COG0037	tRNA processing
HCY95_RS01375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HCY95_RS01380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCY95_RS01385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCY95_RS01450	COG3104	oligopeptide transport
HCY95_RS01475	COG1794	racemase activity, acting on amino acids and derivatives
HCY95_RS01480	COG2188	Transcriptional regulator
HCY95_RS01485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCY95_RS01490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCY95_RS01495	COG2183	response to ionizing radiation
HCY95_RS01500	COG3091	SprT-like family
HCY95_RS01510	COG3250	beta-galactosidase activity
HCY95_RS01515	COG3250	beta-galactosidase activity
HCY95_RS01525	COG0588	phosphoglycerate mutase activity
HCY95_RS01540	COG0110	maltose O-acetyltransferase activity
HCY95_RS01555	COG0756	dUTP diphosphatase activity
HCY95_RS01560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCY95_RS01565	COG4956	integral membrane protein (PIN domain superfamily)
HCY95_RS01570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCY95_RS01580	COG0215	cysteine-tRNA ligase activity
HCY95_RS01585	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCY95_RS01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCY95_RS01600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCY95_RS01610	COG0250	Participates in transcription elongation, termination and antitermination
HCY95_RS01615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCY95_RS01620	COG0081	regulation of translation
HCY95_RS01625	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS01640	COG0531	amino acid
HCY95_RS01645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCY95_RS01650	COG0222	ribosome binding
HCY95_RS01655	COG1271	oxidase subunit
HCY95_RS01660	COG1294	oxidase, subunit
HCY95_RS01665	COG4988	ABC transporter
HCY95_RS01670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCY95_RS01675	COG1012	belongs to the aldehyde dehydrogenase family
HCY95_RS01675	COG1454	alcohol dehydrogenase
HCY95_RS01680	COG1114	Component of the transport system for branched-chain amino acids
HCY95_RS01685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCY95_RS01690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCY95_RS01695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCY95_RS01700	COG0590	tRNA wobble adenosine to inosine editing
HCY95_RS01710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCY95_RS01715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCY95_RS01720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCY95_RS01730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCY95_RS01735	COG3870	Protein conserved in bacteria
HCY95_RS01740	COG0470	DNA polymerase III
HCY95_RS01745	COG4467	Involved in initiation control of chromosome replication
HCY95_RS01765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCY95_RS01770	COG0248	Ppx GppA phosphatase
HCY95_RS01775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCY95_RS01785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCY95_RS01795	COG2235	arginine
HCY95_RS01805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCY95_RS01810	COG0436	Aminotransferase
HCY95_RS01815	COG1214	PFAM Peptidase M22, glycoprotease
HCY95_RS01825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCY95_RS01840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCY95_RS01845	COG1846	Transcriptional regulator
HCY95_RS01850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCY95_RS01860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCY95_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS01870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCY95_RS01875	COG0511	ligase activity, forming carbon-carbon bonds
HCY95_RS01885	COG0439	Biotin carboxylase
HCY95_RS01890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCY95_RS01895	COG0825	malonyl-CoA metabolic process
HCY95_RS01900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCY95_RS01905	COG1268	BioY protein
HCY95_RS01915	COG0488	(ABC) transporter
HCY95_RS01920	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HCY95_RS01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCY95_RS01930	COG0459	protein refolding
HCY95_RS01935	COG0531	amino acid
HCY95_RS01945	COG1739	Uncharacterized protein family UPF0029
HCY95_RS01950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HCY95_RS01965	COG0653	protein targeting
HCY95_RS01970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCY95_RS01980	COG1950	PFAM Membrane protein of
HCY95_RS01985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HCY95_RS01990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCY95_RS01995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCY95_RS02005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCY95_RS02010	COG0436	Aminotransferase
HCY95_RS02015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCY95_RS02025	COG0492	ferredoxin-NADP+ reductase activity
HCY95_RS02030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HCY95_RS02035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCY95_RS02040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCY95_RS02050	COG0561	phosphatase activity
HCY95_RS02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCY95_RS02070	COG0556	nucleotide-excision repair
HCY95_RS02075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCY95_RS02085	COG1660	Displays ATPase and GTPase activities
HCY95_RS02090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCY95_RS02095	COG1481	regulation of sporulation
HCY95_RS02105	COG0740	serine-type endopeptidase activity
HCY95_RS02120	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS02130	COG0126	phosphoglycerate kinase activity
HCY95_RS02135	COG0149	triose-phosphate isomerase activity
HCY95_RS02140	COG0148	phosphopyruvate hydratase activity
HCY95_RS02145	COG1113	amino acid transport
HCY95_RS02160	COG0557	exoribonuclease II activity
HCY95_RS02165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCY95_RS02175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCY95_RS02180	COG0280	phosphate acetyltransferase
HCY95_RS02185	COG0802	atpase or kinase
HCY95_RS02195	COG2176	DNA-directed DNA polymerase activity
HCY95_RS02200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCY95_RS02215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCY95_RS02220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCY95_RS02235	COG0561	phosphatase activity
HCY95_RS02240	COG3942	CHAP domain
HCY95_RS02240	COG1388	LysM domain
HCY95_RS02245	COG2855	membrane
HCY95_RS02250	COG0583	DNA-binding transcription factor activity
HCY95_RS02255	COG1482	cell wall glycoprotein biosynthetic process
HCY95_RS02260	COG1307	EDD domain protein, DegV family
HCY95_RS02280	COG3715	PTS system
HCY95_RS02285	COG3716	PTS system mannose fructose sorbose family IID component
HCY95_RS02295	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS02305	COG0745	RESPONSE REGULATOR receiver
HCY95_RS02310	COG5002	protein histidine kinase activity
HCY95_RS02310	COG3850	Histidine kinase
HCY95_RS02315	COG4975	Glucose uptake
HCY95_RS02330	COG2115	Belongs to the xylose isomerase family
HCY95_RS02350	COG2211	Major facilitator Superfamily
HCY95_RS02355	COG0450	alkyl hydroperoxide reductase
HCY95_RS02385	COG0656	L-ascorbic acid biosynthetic process
HCY95_RS02390	COG0149	triose-phosphate isomerase activity
HCY95_RS02395	COG3527	Alpha-acetolactate decarboxylase
HCY95_RS02430	COG1132	(ABC) transporter
HCY95_RS02435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCY95_RS02450	COG3442	glutamine amidotransferase
HCY95_RS02455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCY95_RS02460	COG1435	thymidine kinase activity
HCY95_RS02465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCY95_RS02470	COG2890	protein-(glutamine-N5) methyltransferase activity
HCY95_RS02475	COG0009	L-threonylcarbamoyladenylate synthase
HCY95_RS02480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCY95_RS02485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCY95_RS02500	COG2233	PERMEase
HCY95_RS02505	COG0356	it plays a direct role in the translocation of protons across the membrane
HCY95_RS02510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCY95_RS02515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCY95_RS02520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCY95_RS02525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCY95_RS02530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCY95_RS02535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCY95_RS02540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCY95_RS02550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCY95_RS02555	COG1077	Cell shape determining protein MreB Mrl
HCY95_RS02560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCY95_RS02570	COG0772	Belongs to the SEDS family
HCY95_RS02585	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCY95_RS02595	COG0589	response to stress
HCY95_RS02605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCY95_RS02625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCY95_RS02640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCY95_RS02645	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HCY95_RS02650	COG1104	cysteine desulfurase activity
HCY95_RS02655	COG0301	tRNA thio-modification
HCY95_RS02660	COG2610	gluconate transmembrane transporter activity
HCY95_RS02665	COG1929	Belongs to the glycerate kinase type-1 family
HCY95_RS02690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCY95_RS02695	COG0525	valine-tRNA ligase activity
HCY95_RS02700	COG0285	dihydrofolate synthase activity
HCY95_RS02710	COG1077	Cell shape determining protein MreB Mrl
HCY95_RS02715	COG1792	Involved in formation and maintenance of cell shape
HCY95_RS02725	COG0765	amino acid transport
HCY95_RS02730	COG1126	abc transporter atp-binding protein
HCY95_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS02740	COG0612	Peptidase, M16
HCY95_RS02745	COG0612	Peptidase, M16
HCY95_RS02750	COG1426	Protein conserved in bacteria
HCY95_RS02755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCY95_RS02760	COG1058	Belongs to the CinA family
HCY95_RS02760	COG1546	Belongs to the CinA family
HCY95_RS02765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCY95_RS02775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCY95_RS02780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCY95_RS02785	COG0632	four-way junction helicase activity
HCY95_RS02790	COG2255	four-way junction helicase activity
HCY95_RS02805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCY95_RS02810	COG0513	Belongs to the DEAD box helicase family
HCY95_RS02815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCY95_RS02820	COG4472	Bacterial protein of unknown function (DUF965)
HCY95_RS02825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCY95_RS02830	COG3906	Belongs to the UPF0473 family
HCY95_RS02835	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCY95_RS02845	COG1193	negative regulation of DNA recombination
HCY95_RS02850	COG3118	belongs to the thioredoxin family
HCY95_RS02865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCY95_RS02870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCY95_RS02875	COG0622	Phosphoesterase
HCY95_RS02880	COG0561	phosphatase activity
HCY95_RS02885	COG0668	transmembrane transport
HCY95_RS02900	COG0006	proline dipeptidase activity
HCY95_RS02905	COG1609	Transcriptional regulator
HCY95_RS02915	COG0217	transcriptional regulatory protein
HCY95_RS02920	COG0791	NLP P60 protein
HCY95_RS02920	COG1388	LysM domain
HCY95_RS02925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCY95_RS02930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCY95_RS02940	COG4537	Required for transformation and DNA binding
HCY95_RS02960	COG0827	DNA restriction-modification system
HCY95_RS02965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCY95_RS02975	COG4470	Protein conserved in bacteria
HCY95_RS02980	COG0647	UMP catabolic process
HCY95_RS02990	COG0586	Pfam SNARE associated Golgi protein
HCY95_RS03110	COG1393	Belongs to the ArsC family
HCY95_RS03115	COG4862	establishment of competence for transformation
HCY95_RS03130	COG2357	RelA SpoT domain protein
HCY95_RS03135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCY95_RS03140	COG0564	pseudouridine synthase activity
HCY95_RS03145	COG2706	6-phosphogluconolactonase activity
HCY95_RS03150	COG0500	methyltransferase
HCY95_RS03160	COG1674	ftsk spoiiie
HCY95_RS03175	COG2001	Belongs to the MraZ family
HCY95_RS03180	COG0275	rRNA processing
HCY95_RS03195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCY95_RS03200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCY95_RS03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCY95_RS03215	COG0849	cell division
HCY95_RS03220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCY95_RS03225	COG1799	cell septum assembly
HCY95_RS03240	COG3599	regulation of cell shape
HCY95_RS03245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCY95_RS03250	COG1278	Cold shock
HCY95_RS03265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCY95_RS03275	COG0482	sulfurtransferase activity
HCY95_RS03290	COG0406	alpha-ribazole phosphatase activity
HCY95_RS03300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCY95_RS03305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCY95_RS03310	COG1393	Belongs to the ArsC family
HCY95_RS03315	COG1597	lipid kinase activity
HCY95_RS03330	COG0242	peptide deformylase activity
HCY95_RS03335	COG4476	Belongs to the UPF0223 family
HCY95_RS03340	COG0483	inositol monophosphate 1-phosphatase activity
HCY95_RS03355	COG4471	UPF0298 protein
HCY95_RS03360	COG0742	ribosomal rna small subunit methyltransferase
HCY95_RS03365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCY95_RS03370	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCY95_RS03375	COG1555	photosystem II stabilization
HCY95_RS03375	COG1596	polysaccharide export
HCY95_RS03380	COG2131	deaminase
HCY95_RS03385	COG0658	competence protein
HCY95_RS03385	COG2333	competence protein COMEC
HCY95_RS03390	COG1466	dna polymerase III delta subunit
HCY95_RS03395	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS03400	COG0268	Binds directly to 16S ribosomal RNA
HCY95_RS03405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCY95_RS03435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCY95_RS03440	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCY95_RS03445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCY95_RS03450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCY95_RS03465	COG1126	abc transporter atp-binding protein
HCY95_RS03470	COG0322	excinuclease ABC activity
HCY95_RS03475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCY95_RS03480	COG1234	tRNA 3'-trailer cleavage
HCY95_RS03485	COG0300	oxidoreductase activity
HCY95_RS03490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCY95_RS03490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCY95_RS03495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCY95_RS03505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCY95_RS03520	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCY95_RS03540	COG1396	sequence-specific DNA binding
HCY95_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS03565	COG2197	response regulator
HCY95_RS03585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCY95_RS03610	COG2814	Major facilitator Superfamily
HCY95_RS03625	COG0367	asparagine synthase
HCY95_RS03640	COG1397	ADP-ribosylglycohydrolase
HCY95_RS03650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCY95_RS03665	COG1609	Transcriptional regulator
HCY95_RS03715	COG1760	l-serine dehydratase
HCY95_RS03720	COG1760	l-serine dehydratase
HCY95_RS03725	COG2151	metal-sulfur cluster biosynthetic enzyme
HCY95_RS03755	COG1556	Lactate utilization protein
HCY95_RS03760	COG1139	Iron-sulfur cluster binding protein
HCY95_RS03765	COG0247	lactate metabolic process
HCY95_RS03770	COG3425	synthase
HCY95_RS03775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCY95_RS03780	COG4224	UPF0291 protein
HCY95_RS03785	COG3763	UPF0154 protein
HCY95_RS03790	COG0204	Acyl-transferase
HCY95_RS03795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCY95_RS03800	COG2827	Endonuclease containing a URI domain
HCY95_RS03805	COG0052	Belongs to the universal ribosomal protein uS2 family
HCY95_RS03810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCY95_RS03820	COG0233	cytoplasmic translational termination
HCY95_RS03825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCY95_RS03830	COG4589	Belongs to the CDS family
HCY95_RS03835	COG0750	zinc metalloprotease
HCY95_RS03840	COG0442	prolyl-tRNA aminoacylation
HCY95_RS03845	COG2176	DNA-directed DNA polymerase activity
HCY95_RS03850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCY95_RS03855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCY95_RS03860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCY95_RS03865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCY95_RS03870	COG0505	Belongs to the CarA family
HCY95_RS03875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCY95_RS03880	COG0779	Required for maturation of 30S ribosomal subunits
HCY95_RS03885	COG0195	Participates in both transcription termination and antitermination
HCY95_RS03890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HCY95_RS03900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCY95_RS03905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCY95_RS03910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCY95_RS03915	COG0196	riboflavin kinase activity
HCY95_RS03920	COG2814	Major facilitator Superfamily
HCY95_RS03950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCY95_RS03975	COG3759	membrane
HCY95_RS03985	COG3048	D-serine ammonia-lyase activity
HCY95_RS03990	COG1113	amino acid transport
HCY95_RS04000	COG2801	Transposase and inactivated derivatives
HCY95_RS04020	COG1420	regulation of RNA biosynthetic process
HCY95_RS04025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCY95_RS04030	COG0443	Heat shock 70 kDa protein
HCY95_RS04035	COG0484	heat shock protein binding
HCY95_RS04040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCY95_RS04045	COG0107	imidazoleglycerol-phosphate synthase activity
HCY95_RS04050	COG0107	imidazoleglycerol-phosphate synthase activity
HCY95_RS04055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCY95_RS04060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCY95_RS04065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCY95_RS04070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCY95_RS04075	COG0131	Imidazoleglycerol-phosphate dehydratase
HCY95_RS04080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCY95_RS04085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCY95_RS04090	COG0107	imidazoleglycerol-phosphate synthase activity
HCY95_RS04095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCY95_RS04100	COG0140	phosphoribosyl-ATP diphosphatase activity
HCY95_RS04105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCY95_RS04110	COG0481	GTPase activity
HCY95_RS04125	COG0406	alpha-ribazole phosphatase activity
HCY95_RS04130	COG0667	Aldo Keto reductase
HCY95_RS04135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCY95_RS04140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCY95_RS04155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCY95_RS04165	COG0307	riboflavin synthase, alpha
HCY95_RS04170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCY95_RS04170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCY95_RS04195	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS04200	COG1104	cysteine desulfurase activity
HCY95_RS04220	COG1811	Na channel or pump
HCY95_RS04225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCY95_RS04235	COG1464	Belongs to the NlpA lipoprotein family
HCY95_RS04240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCY95_RS04260	COG0067	glutamate synthase
HCY95_RS04260	COG0069	glutamate synthase activity
HCY95_RS04260	COG0070	glutamate synthase
HCY95_RS04265	COG0493	'glutamate synthase
HCY95_RS04280	COG0351	phosphomethylpyrimidine kinase
HCY95_RS04285	COG0352	thiamine-phosphate diphosphorylase activity
HCY95_RS04290	COG0351	phosphomethylpyrimidine kinase
HCY95_RS04295	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HCY95_RS04310	COG1518	maintenance of DNA repeat elements
HCY95_RS04345	COG0039	L-malate dehydrogenase activity
HCY95_RS04355	COG2264	protein methyltransferase activity
HCY95_RS04360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCY95_RS04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCY95_RS04375	COG1490	D-aminoacyl-tRNA deacylase activity
HCY95_RS04385	COG0626	cystathionine gamma-synthase activity
HCY95_RS04390	COG0626	cystathionine gamma-synthase activity
HCY95_RS04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS04400	COG0456	acetyltransferase
HCY95_RS04405	COG0765	amino acid transport
HCY95_RS04410	COG1126	abc transporter atp-binding protein
HCY95_RS04415	COG1473	amidohydrolase
HCY95_RS04430	COG2801	Transposase and inactivated derivatives
HCY95_RS04440	COG2079	MmgE PrpD family protein
HCY95_RS04445	COG0765	amino acid transport
HCY95_RS04450	COG0765	amino acid transport
HCY95_RS04455	COG1126	abc transporter atp-binding protein
HCY95_RS04470	COG0460	homoserine dehydrogenase
HCY95_RS04475	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HCY95_RS04480	COG0833	amino acid
HCY95_RS04485	COG2040	homocysteine
HCY95_RS04490	COG3001	Fructosamine kinase
HCY95_RS04495	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCY95_RS04505	COG0124	histidyl-tRNA synthetase
HCY95_RS04510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCY95_RS04520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCY95_RS04525	COG1610	YqeY-like protein
HCY95_RS04530	COG1702	phosphate starvation-inducible protein PhoH
HCY95_RS04535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCY95_RS04540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCY95_RS04545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCY95_RS04550	COG1381	Involved in DNA repair and RecF pathway recombination
HCY95_RS04555	COG0752	glycyl-tRNA synthetase alpha subunit
HCY95_RS04560	COG0751	glycine-tRNA ligase activity
HCY95_RS04565	COG0358	DNA primase activity
HCY95_RS04570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCY95_RS04580	COG2801	Transposase and inactivated derivatives
HCY95_RS04605	COG2261	transglycosylase associated protein
HCY95_RS04615	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS04630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCY95_RS04635	COG0527	aspartate kinase activity
HCY95_RS04640	COG0019	diaminopimelate decarboxylase activity
HCY95_RS04645	COG2171	N-acyltransferase activity
HCY95_RS04650	COG1473	amidohydrolase
HCY95_RS04655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCY95_RS04660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCY95_RS04665	COG0436	Aminotransferase
HCY95_RS04670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCY95_RS04675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCY95_RS04680	COG0569	domain protein
HCY95_RS04685	COG2384	SAM-dependent methyltransferase
HCY95_RS04690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCY95_RS04695	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCY95_RS04705	COG0587	DNA-directed DNA polymerase activity
HCY95_RS04720	COG4974	Belongs to the 'phage' integrase family
HCY95_RS04730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HCY95_RS04735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HCY95_RS04740	COG1187	pseudouridine synthase activity
HCY95_RS04745	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HCY95_RS04755	COG0514	ATP-dependent DNA helicase (RecQ)
HCY95_RS04765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCY95_RS04770	COG0539	negative regulation of cytoplasmic translation
HCY95_RS04775	COG1160	GTP binding
HCY95_RS04785	COG0457	Tetratricopeptide repeat
HCY95_RS04795	COG0617	tRNA 3'-terminal CCA addition
HCY95_RS04800	COG0488	(ABC) transporter
HCY95_RS04805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCY95_RS04810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCY95_RS04815	COG1272	protein, Hemolysin III
HCY95_RS04820	COG1307	EDD domain protein, DegV family
HCY95_RS04825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCY95_RS04835	COG2755	lipolytic protein G-D-S-L family
HCY95_RS04840	COG4698	Protein conserved in bacteria
HCY95_RS04845	COG4479	Belongs to the UPF0346 family
HCY95_RS04870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCY95_RS04885	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCY95_RS04925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCY95_RS04930	COG0758	DNA mediated transformation
HCY95_RS04935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCY95_RS04950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCY95_RS04955	COG0187	DNA topoisomerase II activity
HCY95_RS04960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCY95_RS04980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCY95_RS04990	COG1956	GAF domain-containing protein
HCY95_RS05000	COG0402	S-adenosylhomocysteine deaminase activity
HCY95_RS05015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCY95_RS05020	COG1811	Na channel or pump
HCY95_RS05025	COG2223	nitrite transmembrane transporter activity
HCY95_RS05040	COG2814	Major facilitator Superfamily
HCY95_RS05050	COG0038	chloride channel
HCY95_RS05085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCY95_RS05090	COG0110	maltose O-acetyltransferase activity
HCY95_RS05105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCY95_RS05110	COG0477	Major facilitator Superfamily
HCY95_RS05165	COG0656	L-ascorbic acid biosynthetic process
HCY95_RS05170	COG4720	Psort location CytoplasmicMembrane, score
HCY95_RS05190	COG4974	Belongs to the 'phage' integrase family
HCY95_RS05195	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HCY95_RS05200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCY95_RS05205	COG1063	alcohol dehydrogenase
HCY95_RS05230	COG1732	Glycine betaine
HCY95_RS05280	COG3328	transposase activity
HCY95_RS05290	COG2390	Transcriptional regulator
HCY95_RS05300	COG2801	Transposase and inactivated derivatives
HCY95_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
HCY95_RS05340	COG2271	Major facilitator Superfamily
HCY95_RS05350	COG0626	cystathionine gamma-synthase activity
HCY95_RS05355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCY95_RS05365	COG2848	UPF0210 protein
HCY95_RS05400	COG0697	spore germination
HCY95_RS05410	COG1053	succinate dehydrogenase
HCY95_RS05410	COG3976	FMN-binding domain protein
HCY95_RS05415	COG0583	DNA-binding transcription factor activity
HCY95_RS05425	COG0183	Belongs to the thiolase family
HCY95_RS05430	COG0628	permease
HCY95_RS05435	COG0730	response to heat
HCY95_RS05440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCY95_RS05445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCY95_RS05470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCY95_RS05480	COG4690	dipeptidase activity
HCY95_RS05490	COG1113	amino acid transport
HCY95_RS05500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCY95_RS05515	COG0105	UTP biosynthetic process
HCY95_RS05520	COG1695	Transcriptional regulator
HCY95_RS05530	COG0675	Transposase, IS605 OrfB family
HCY95_RS05540	COG3328	transposase activity
HCY95_RS05570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCY95_RS05640	COG0402	S-adenosylhomocysteine deaminase activity
HCY95_RS05645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCY95_RS05655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCY95_RS05685	COG0789	Transcriptional regulator
HCY95_RS05690	COG0390	transport system, permease component
HCY95_RS05695	COG4619	ABC transporter
HCY95_RS05700	COG0028	Belongs to the TPP enzyme family
HCY95_RS05735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCY95_RS05760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCY95_RS05790	COG1940	carbohydrate kinase activity
HCY95_RS05800	COG3682	Transcriptional regulator
HCY95_RS05820	COG2610	gluconate transmembrane transporter activity
HCY95_RS05825	COG1609	Transcriptional regulator
HCY95_RS05835	COG0436	Aminotransferase
HCY95_RS05870	COG2181	nitrate reductase activity
HCY95_RS05880	COG1140	nitrate reductase beta subunit
HCY95_RS05885	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCY95_RS05890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCY95_RS05905	COG0315	cyclic pyranopterin monophosphate synthase activity
HCY95_RS05930	COG2197	response regulator
HCY95_RS05955	COG2226	methyltransferase
HCY95_RS05965	COG2151	metal-sulfur cluster biosynthetic enzyme
HCY95_RS05970	COG2223	nitrite transmembrane transporter activity
HCY95_RS05975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCY95_RS06000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HCY95_RS06005	COG1252	NADH dehydrogenase
HCY95_RS06010	COG2151	metal-sulfur cluster biosynthetic enzyme
HCY95_RS06030	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS06045	COG0822	iron-sulfur transferase activity
HCY95_RS06050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCY95_RS06055	COG0719	Fe-S assembly protein
HCY95_RS06090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCY95_RS06095	COG0436	Aminotransferase
HCY95_RS06100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCY95_RS06105	COG0287	Prephenate dehydrogenase
HCY95_RS06110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCY95_RS06120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCY95_RS06125	COG1605	Chorismate mutase
HCY95_RS06125	COG0077	Prephenate dehydratase
HCY95_RS06130	COG0738	Major facilitator superfamily
HCY95_RS06135	COG3104	oligopeptide transport
HCY95_RS06145	COG0561	phosphatase activity
HCY95_RS06160	COG0477	Major facilitator Superfamily
HCY95_RS06190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCY95_RS06195	COG1942	4-Oxalocrotonate Tautomerase
HCY95_RS06200	COG0569	domain protein
HCY95_RS06200	COG0475	glutathione-regulated potassium exporter activity
HCY95_RS06215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCY95_RS06220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCY95_RS06230	COG0675	Transposase, IS605 OrfB family
HCY95_RS06240	COG0477	Major facilitator Superfamily
HCY95_RS06250	COG1253	flavin adenine dinucleotide binding
HCY95_RS06255	COG2814	Major facilitator Superfamily
HCY95_RS06270	COG0583	DNA-binding transcription factor activity
HCY95_RS06280	COG0095	Lipoate-protein ligase
HCY95_RS06310	COG1687	branched-chain amino acid
HCY95_RS06315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCY95_RS06325	COG0460	homoserine dehydrogenase
HCY95_RS06330	COG0083	homoserine kinase activity
HCY95_RS06340	COG0702	epimerase
HCY95_RS06345	COG1418	mRNA catabolic process
HCY95_RS06350	COG3022	response to hydroperoxide
HCY95_RS06360	COG1307	EDD domain protein, DegV family
HCY95_RS06365	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HCY95_RS06380	COG3328	transposase activity
HCY95_RS06390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCY95_RS06395	COG0505	Belongs to the CarA family
HCY95_RS06400	COG0564	pseudouridine synthase activity
HCY95_RS06415	COG0328	RNA-DNA hybrid ribonuclease activity
HCY95_RS06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS06430	COG0765	amino acid transport
HCY95_RS06435	COG1216	Glycosyl transferase, family 2
HCY95_RS06435	COG1442	glycosyl transferase family 8
HCY95_RS06445	COG2801	Transposase and inactivated derivatives
HCY95_RS06455	COG0154	amidase activity
HCY95_RS06465	COG0116	Belongs to the methyltransferase superfamily
HCY95_RS06470	COG1051	belongs to the nudix hydrolase family
HCY95_RS06485	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS06495	COG3599	regulation of cell shape
HCY95_RS06500	COG4474	Belongs to the UPF0398 family
HCY95_RS06505	COG3331	DNA recombination
HCY95_RS06515	COG0697	spore germination
HCY95_RS06520	COG0667	Aldo Keto reductase
HCY95_RS06545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCY95_RS06545	COG1199	ATP-dependent helicase activity
HCY95_RS06570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCY95_RS06575	COG0581	inorganic phosphate transmembrane transporter activity
HCY95_RS06580	COG0573	inorganic phosphate transmembrane transporter activity
HCY95_RS06590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HCY95_RS06590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCY95_RS06595	COG0561	phosphatase activity
HCY95_RS06600	COG0167	dihydroorotate dehydrogenase activity
HCY95_RS06605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCY95_RS06610	COG0505	Belongs to the CarA family
HCY95_RS06615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCY95_RS06625	COG4336	lyase activity
HCY95_RS06630	COG5263	repeat protein
HCY95_RS06630	COG0366	Alpha amylase catalytic
HCY95_RS06635	COG0335	large ribosomal subunit rRNA binding
HCY95_RS06640	COG0531	amino acid
HCY95_RS06645	COG0336	Belongs to the RNA methyltransferase TrmD family
HCY95_RS06650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCY95_RS06655	COG1837	Belongs to the UPF0109 family
HCY95_RS06660	COG0228	four-way junction DNA binding
HCY95_RS06670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCY95_RS06675	COG0581	inorganic phosphate transmembrane transporter activity
HCY95_RS06680	COG0573	inorganic phosphate transmembrane transporter activity
HCY95_RS06685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCY95_RS06690	COG0745	RESPONSE REGULATOR receiver
HCY95_RS06705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCY95_RS06710	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HCY95_RS06715	COG0552	protein localization to endoplasmic reticulum
HCY95_RS06720	COG1196	nuclear chromosome segregation
HCY95_RS06725	COG0571	ribonuclease III activity
HCY95_RS06730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCY95_RS06735	COG0416	fatty acid biosynthetic process
HCY95_RS06740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCY95_RS06745	COG1461	Dihydroxyacetone kinase
HCY95_RS06755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCY95_RS06760	COG1564	THIamine pyrophosphokinase
HCY95_RS06765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCY95_RS06770	COG1162	GTPase activity
HCY95_RS06775	COG0515	serine threonine protein kinase
HCY95_RS06775	COG2815	serine threonine protein kinase
HCY95_RS06785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCY95_RS06785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCY95_RS06790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCY95_RS06795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCY95_RS06800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCY95_RS06805	COG1758	RNA polymerase activity
HCY95_RS06830	COG0497	DNA recombination
HCY95_RS06835	COG1438	arginine binding
HCY95_RS06840	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCY95_RS06855	COG1570	exodeoxyribonuclease VII activity
HCY95_RS06860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCY95_RS06865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCY95_RS06870	COG1302	Protein conserved in bacteria
HCY95_RS06875	COG0006	proline dipeptidase activity
HCY95_RS06880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCY95_RS06890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCY95_RS06895	COG1309	transcriptional regulator
HCY95_RS06910	COG3421	Type III restriction
HCY95_RS06915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCY95_RS07015	COG0228	four-way junction DNA binding
HCY95_RS07035	COG1802	Transcriptional regulator
HCY95_RS07035	COG4626	Terminase
HCY95_RS07105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCY95_RS07160	COG3646	Phage regulatory protein
HCY95_RS07160	COG3645	SOS response
HCY95_RS07170	COG1396	sequence-specific DNA binding
HCY95_RS07225	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS07255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCY95_RS07265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCY95_RS07270	COG1940	carbohydrate kinase activity
HCY95_RS07285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCY95_RS07290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCY95_RS07295	COG0768	penicillin binding
HCY95_RS07305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCY95_RS07310	COG0572	uridine kinase
HCY95_RS07315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCY95_RS07315	COG0072	phenylalanine-tRNA ligase activity
HCY95_RS07320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCY95_RS07325	COG1733	regulation of RNA biosynthetic process
HCY95_RS07335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCY95_RS07340	COG1254	Belongs to the acylphosphatase family
HCY95_RS07345	COG0706	membrane insertase activity
HCY95_RS07350	COG0242	peptide deformylase activity
HCY95_RS07360	COG5002	protein histidine kinase activity
HCY95_RS07365	COG0745	RESPONSE REGULATOR receiver
HCY95_RS07370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCY95_RS07380	COG1323	Belongs to the UPF0348 family
HCY95_RS07385	COG2226	methyltransferase
HCY95_RS07390	COG0799	negative regulation of ribosome biogenesis
HCY95_RS07400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCY95_RS07410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCY95_RS07425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCY95_RS07430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCY95_RS07435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCY95_RS07440	COG1484	DNA-dependent DNA replication
HCY95_RS07450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCY95_RS07455	COG0237	dephospho-CoA kinase activity
HCY95_RS07460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCY95_RS07475	COG0675	Transposase, IS605 OrfB family
HCY95_RS07485	COG0670	Belongs to the BI1 family
HCY95_RS07490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCY95_RS07495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCY95_RS07500	COG3118	belongs to the thioredoxin family
HCY95_RS07510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCY95_RS07520	COG1131	(ABC) transporter
HCY95_RS07525	COG0537	adenosine 5'-monophosphoramidase activity
HCY95_RS07540	COG3481	metal-dependent phosphohydrolase, HD sub domain
HCY95_RS07545	COG3679	Belongs to the UPF0342 family
HCY95_RS07550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCY95_RS07555	COG0018	arginyl-trna synthetase
HCY95_RS07575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCY95_RS07580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCY95_RS07590	COG0302	gtp cyclohydrolase
HCY95_RS07595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCY95_RS07595	COG0302	gtp cyclohydrolase
HCY95_RS07610	COG1609	Transcriptional regulator
HCY95_RS07620	COG1428	Deoxynucleoside kinase
HCY95_RS07625	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCY95_RS07625	COG1388	LysM domain
HCY95_RS07635	COG0589	response to stress
HCY95_RS07640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCY95_RS07645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCY95_RS07655	COG2244	polysaccharide biosynthetic process
HCY95_RS07665	COG0495	leucyl-tRNA aminoacylation
HCY95_RS07670	COG0671	phosphoesterase, PA-phosphatase related
HCY95_RS07675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCY95_RS07680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCY95_RS07685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCY95_RS07695	COG2818	Glycosylase
HCY95_RS07700	COG2814	Major facilitator Superfamily
HCY95_RS07710	COG1113	amino acid transport
HCY95_RS07755	COG1607	acyl-coa hydrolase
HCY95_RS07770	COG2233	PERMEase
HCY95_RS07780	COG0602	queuosine metabolic process
HCY95_RS07790	COG0765	amino acid transport
HCY95_RS07795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS07800	COG2076	Multidrug Resistance protein
HCY95_RS07895	COG0438	transferase activity, transferring glycosyl groups
HCY95_RS07900	COG0438	transferase activity, transferring glycosyl groups
HCY95_RS07905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCY95_RS07920	COG0542	response to heat
HCY95_RS07930	COG1335	isochorismatase
HCY95_RS07935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCY95_RS07950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCY95_RS07975	COG1131	(ABC) transporter
HCY95_RS07980	COG2188	Transcriptional regulator
HCY95_RS07985	COG1088	dTDP-glucose 4,6-dehydratase activity
HCY95_RS07995	COG1215	transferase activity, transferring glycosyl groups
HCY95_RS08000	COG0438	transferase activity, transferring glycosyl groups
HCY95_RS08005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HCY95_RS08010	COG0463	Glycosyl transferase, family 2
HCY95_RS08015	COG0628	permease
HCY95_RS08020	COG0463	Glycosyl transferase, family 2
HCY95_RS08030	COG0791	NLP P60 protein
HCY95_RS08045	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCY95_RS08060	COG0562	UDP-galactopyranose mutase
HCY95_RS08080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCY95_RS08085	COG2137	regulation of response to DNA damage stimulus
HCY95_RS08100	COG1295	ribonuclease BN
HCY95_RS08110	COG0024	Methionine aminopeptidase
HCY95_RS08115	COG0716	FMN binding
HCY95_RS08120	COG2246	polysaccharide biosynthetic process
HCY95_RS08135	COG0513	Belongs to the DEAD box helicase family
HCY95_RS08150	COG2826	transposase and inactivated derivatives, IS30 family
HCY95_RS08165	COG2918	glutathione biosynthetic process
HCY95_RS08175	COG4841	protein insertion into membrane
HCY95_RS08180	COG0488	(ABC) transporter
HCY95_RS08185	COG0783	Belongs to the Dps family
HCY95_RS08195	COG1316	TRANSCRIPTIONal
HCY95_RS08200	COG1846	Transcriptional regulator
HCY95_RS08210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCY95_RS08225	COG2226	methyltransferase
HCY95_RS08245	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HCY95_RS08265	COG0673	inositol 2-dehydrogenase activity
HCY95_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCY95_RS08320	COG2801	Transposase and inactivated derivatives
HCY95_RS08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCY95_RS08370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCY95_RS08375	COG1597	lipid kinase activity
HCY95_RS08380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCY95_RS08385	COG0154	amidase activity
HCY95_RS08390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCY95_RS08395	COG4851	CamS sex pheromone cAM373 precursor
HCY95_RS08400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCY95_RS08415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCY95_RS08420	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCY95_RS08435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCY95_RS08440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCY95_RS08445	COG0101	tRNA pseudouridine synthase activity
HCY95_RS08455	COG1122	ATPase activity
HCY95_RS08460	COG1122	ATPase activity
HCY95_RS08465	COG0203	ribosomal protein L17
HCY95_RS08470	COG0202	RNA polymerase activity
HCY95_RS08475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCY95_RS08480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCY95_RS08485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCY95_RS08490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCY95_RS08495	COG0563	adenylate kinase activity
HCY95_RS08505	COG0200	Binds to the 23S rRNA
HCY95_RS08510	COG1841	ribosomal large subunit assembly
HCY95_RS08515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCY95_RS08520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCY95_RS08525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCY95_RS08530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCY95_RS08535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCY95_RS08540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCY95_RS08545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCY95_RS08550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCY95_RS08560	COG0255	Belongs to the universal ribosomal protein uL29 family
HCY95_RS08565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCY95_RS08570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCY95_RS08575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCY95_RS08580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCY95_RS08585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCY95_RS08590	COG0089	rRNA binding
HCY95_RS08595	COG0088	Forms part of the polypeptide exit tunnel
HCY95_RS08600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCY95_RS08605	COG0051	transcription antitermination factor activity, RNA binding
HCY95_RS08610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCY95_RS08615	COG0049	tRNA binding
HCY95_RS08620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCY95_RS08625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCY95_RS08635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCY95_RS08640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCY95_RS08645	COG0085	RNA polymerase activity
HCY95_RS08655	COG0542	response to heat
HCY95_RS08660	COG4463	regulation of RNA biosynthetic process
HCY95_RS08665	COG1064	alcohol dehydrogenase
HCY95_RS08680	COG0110	maltose O-acetyltransferase activity
HCY95_RS08695	COG0789	Transcriptional regulator
HCY95_RS08715	COG1968	undecaprenyl-diphosphatase activity
HCY95_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS08760	COG1428	Deoxynucleoside kinase
HCY95_RS08765	COG0833	amino acid
HCY95_RS08795	COG1278	Cold shock
HCY95_RS08850	COG2814	Major facilitator Superfamily
HCY95_RS08860	COG2160	L-arabinose isomerase activity
HCY95_RS08870	COG1609	Transcriptional regulator
HCY95_RS08885	COG0564	pseudouridine synthase activity
HCY95_RS08895	COG0392	lysyltransferase activity
HCY95_RS08895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCY95_RS08900	COG0693	protein deglycase activity
HCY95_RS08905	COG0657	acetylesterase activity
HCY95_RS08930	COG2801	Transposase and inactivated derivatives
HCY95_RS08935	COG2267	carboxylic ester hydrolase activity
HCY95_RS08955	COG3052	prosthetic group binding
HCY95_RS08965	COG0281	malic enzyme
HCY95_RS08975	COG0471	metal ion transport
HCY95_RS08980	COG0039	L-malate dehydrogenase activity
HCY95_RS08985	COG1053	succinate dehydrogenase
HCY95_RS08990	COG0114	fumarate hydratase activity
HCY95_RS08995	COG0431	NADPH-dependent FMN reductase
HCY95_RS08995	COG1053	succinate dehydrogenase
HCY95_RS08995	COG3976	FMN-binding domain protein
HCY95_RS09000	COG1053	succinate dehydrogenase
HCY95_RS09000	COG0431	NADPH-dependent FMN reductase
HCY95_RS09000	COG3976	FMN-binding domain protein
HCY95_RS09005	COG0281	malic enzyme
HCY95_RS09010	COG0583	DNA-binding transcription factor activity
HCY95_RS09035	COG1192	Involved in chromosome partitioning
HCY95_RS09085	COG2190	(PTS) system
HCY95_RS09085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCY95_RS09085	COG1263	PTS System
HCY95_RS09105	COG0583	DNA-binding transcription factor activity
HCY95_RS09110	COG2326	polyphosphate kinase activity
HCY95_RS09130	COG1686	Belongs to the peptidase S11 family
HCY95_RS09140	COG2706	6-phosphogluconolactonase activity
HCY95_RS09160	COG0494	nUDIX hydrolase
HCY95_RS09170	COG2814	Major facilitator Superfamily
HCY95_RS09190	COG1854	S-ribosylhomocysteine lyase activity
HCY95_RS09195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCY95_RS09200	COG1011	Hydrolase
HCY95_RS09205	COG2502	aspartate--ammonia ligase
HCY95_RS09220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCY95_RS09230	COG0789	Transcriptional regulator
HCY95_RS09235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCY95_RS09250	COG0439	Biotin carboxylase
HCY95_RS09255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCY95_RS09260	COG1914	H( )-stimulated, divalent metal cation uptake system
HCY95_RS09275	COG0675	Transposase, IS605 OrfB family
HCY95_RS09285	COG3118	belongs to the thioredoxin family
HCY95_RS09320	COG0531	amino acid
HCY95_RS09330	COG0494	nUDIX hydrolase
HCY95_RS09335	COG0110	maltose O-acetyltransferase activity
HCY95_RS09340	COG0165	Argininosuccinate lyase
HCY95_RS09360	COG0577	efflux transmembrane transporter activity
HCY95_RS09360	COG1136	(ABC) transporter
HCY95_RS09375	COG1136	(ABC) transporter
HCY95_RS09375	COG0577	efflux transmembrane transporter activity
HCY95_RS09390	COG0393	Putative heavy-metal-binding
HCY95_RS09400	COG2070	2-Nitropropane dioxygenase
HCY95_RS09405	COG0640	Transcriptional regulator
HCY95_RS09425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCY95_RS09440	COG0675	Transposase, IS605 OrfB family
HCY95_RS09495	COG0519	Catalyzes the synthesis of GMP from XMP
HCY95_RS09500	COG2357	RelA SpoT domain protein
HCY95_RS09505	COG0745	RESPONSE REGULATOR receiver
HCY95_RS09510	COG5002	protein histidine kinase activity
HCY95_RS09515	COG1072	(Pantothenic acid kinase))
HCY95_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS09530	COG1368	sulfuric ester hydrolase activity
HCY95_RS09540	COG3973	AAA domain
HCY95_RS09545	COG0586	Pfam SNARE associated Golgi protein
HCY95_RS09555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCY95_RS09560	COG4948	Mandelate Racemase Muconate Lactonizing
HCY95_RS09570	COG0531	amino acid
HCY95_RS09580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCY95_RS09590	COG1215	transferase activity, transferring glycosyl groups
HCY95_RS09605	COG1511	domain protein
HCY95_RS09615	COG2017	converts alpha-aldose to the beta-anomer
HCY95_RS09630	COG0735	belongs to the Fur family
HCY95_RS09635	COG0194	GDP metabolic process
HCY95_RS09645	COG0531	amino acid
HCY95_RS09650	COG2936	dipeptidyl-peptidase activity
HCY95_RS09655	COG0675	Transposase, IS605 OrfB family
HCY95_RS09665	COG2267	carboxylic ester hydrolase activity
HCY95_RS09680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCY95_RS09685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCY95_RS09690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCY95_RS09700	COG1376	ErfK ybiS ycfS ynhG family protein
HCY95_RS09715	COG0488	(ABC) transporter
HCY95_RS09725	COG4120	Belongs to the binding-protein-dependent transport system permease family
HCY95_RS09730	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HCY95_RS09750	COG0004	ammonium transporteR
HCY95_RS09755	COG0534	Mate efflux family protein
HCY95_RS09760	COG1940	carbohydrate kinase activity
HCY95_RS09770	COG1609	Transcriptional regulator
HCY95_RS09775	COG2084	Dehydrogenase
HCY95_RS09785	COG3118	belongs to the thioredoxin family
HCY95_RS09790	COG0861	Integral membrane protein TerC family
HCY95_RS09795	COG0564	pseudouridine synthase activity
HCY95_RS09805	COG2233	PERMEase
HCY95_RS09810	COG0702	epimerase
HCY95_RS09815	COG0406	alpha-ribazole phosphatase activity
HCY95_RS09820	COG1368	sulfuric ester hydrolase activity
HCY95_RS09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCY95_RS09840	COG2217	Heavy metal translocating P-type atpase
HCY95_RS09845	COG2217	Heavy metal translocating P-type atpase
HCY95_RS09850	COG0492	ferredoxin-NADP+ reductase activity
HCY95_RS09855	COG1957	nucleoside hydrolase
HCY95_RS09865	COG1122	ATPase activity
HCY95_RS09885	COG0095	Lipoate-protein ligase
HCY95_RS09900	COG1396	sequence-specific DNA binding
HCY95_RS09920	COG0589	response to stress
HCY95_RS09945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCY95_RS09950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HCY95_RS09970	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HCY95_RS09975	COG1606	tRNA processing
HCY95_RS09980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCY95_RS09985	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HCY95_RS09990	COG1691	(AIR) carboxylase
HCY95_RS09995	COG3875	lactate racemase activity
HCY95_RS10000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCY95_RS10015	COG3328	transposase activity
HCY95_RS10035	COG1869	D-ribose catabolic process
HCY95_RS10045	COG2390	Transcriptional regulator
HCY95_RS10050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCY95_RS10060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCY95_RS10065	COG3775	system Galactitol-specific IIC component
HCY95_RS10070	COG1609	Transcriptional regulator
HCY95_RS10090	COG0561	phosphatase activity
HCY95_RS10095	COG2188	Transcriptional regulator
HCY95_RS10100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCY95_RS10130	COG1253	flavin adenine dinucleotide binding
HCY95_RS10145	COG2807	transmembrane transport
HCY95_RS10155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCY95_RS10160	COG0589	response to stress
HCY95_RS10165	COG1522	sequence-specific DNA binding
HCY95_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
HCY95_RS10175	COG1609	Transcriptional regulator
HCY95_RS10180	COG1164	Oligoendopeptidase f
HCY95_RS10185	COG1301	dicarboxylic acid transport
HCY95_RS10205	COG0277	FAD linked oxidase domain protein
HCY95_RS10225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCY95_RS10225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCY95_RS10245	COG0577	efflux transmembrane transporter activity
HCY95_RS10255	COG3328	transposase activity
HCY95_RS10285	COG1609	Transcriptional regulator
HCY95_RS10290	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCY95_RS10295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCY95_RS10305	COG2365	Tyrosine phosphatase family
HCY95_RS10310	COG1881	PFAM PEBP family protein
HCY95_RS10320	COG1126	abc transporter atp-binding protein
HCY95_RS10325	COG0765	amino acid transport
HCY95_RS10330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCY95_RS10340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCY95_RS10345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCY95_RS10355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HCY95_RS10360	COG3590	peptidase
HCY95_RS10365	COG2252	PERMEase
HCY95_RS10385	COG2094	Belongs to the DNA glycosylase MPG family
HCY95_RS10390	COG3189	MarR family transcriptional regulator
HCY95_RS10400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCY95_RS10410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCY95_RS10415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCY95_RS10430	COG1609	Transcriptional regulator
HCY95_RS10435	COG1388	LysM domain
HCY95_RS10435	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCY95_RS10440	COG0640	Transcriptional regulator
HCY95_RS10445	COG0675	Transposase, IS605 OrfB family
HCY95_RS10475	COG1063	alcohol dehydrogenase
HCY95_RS10490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCY95_RS10515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCY95_RS10520	COG0367	asparagine synthase
HCY95_RS10525	COG0833	amino acid
HCY95_RS10530	COG1970	mechanosensitive ion channel activity
HCY95_RS10535	COG0445	tRNA wobble uridine modification
HCY95_RS10540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCY95_RS10550	COG0706	membrane insertase activity
HCY95_RS10555	COG0594	ribonuclease P activity
HCY95_RS10560	COG0230	Belongs to the bacterial ribosomal protein bL34 family