locus-tag	class	description
LAF_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LAF_RS00010	COG0592	DNA-directed DNA polymerase activity
LAF_RS00015	COG2501	S4 domain
LAF_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LAF_RS00025	COG0187	DNA topoisomerase II activity
LAF_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LAF_RS00040	COG0629	single-stranded DNA binding
LAF_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LAF_RS00055	COG0359	binds to the 23S rRNA
LAF_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LAF_RS00080	COG0745	RESPONSE REGULATOR receiver
LAF_RS00100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LAF_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAF_RS00110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LAF_RS00115	COG1959	2 iron, 2 sulfur cluster binding
LAF_RS00120	COG1609	Transcriptional regulator
LAF_RS00130	COG1554	hydrolase, family 65, central catalytic
LAF_RS00135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAF_RS00160	COG0436	Aminotransferase
LAF_RS00180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LAF_RS00185	COG1074	ATP-dependent DNA helicase activity
LAF_RS00190	COG0656	L-ascorbic acid biosynthetic process
LAF_RS00225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LAF_RS00235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LAF_RS00240	COG0284	orotidine-5'-phosphate decarboxylase activity
LAF_RS00245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LAF_RS00265	COG0438	transferase activity, transferring glycosyl groups
LAF_RS00295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAF_RS00310	COG0667	Aldo Keto reductase
LAF_RS00315	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LAF_RS00325	COG1696	Membrane protein involved in D-alanine export
LAF_RS00330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LAF_RS00340	COG0420	3'-5' exonuclease activity
LAF_RS00345	COG0419	ATPase involved in DNA repair
LAF_RS00350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LAF_RS00365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LAF_RS00370	COG0765	amino acid transport
LAF_RS00380	COG1113	amino acid transport
LAF_RS00395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAF_RS00405	COG0357	Ribosomal RNA small subunit methyltransferase G
LAF_RS00415	COG1475	DNA binding
LAF_RS00420	COG4481	Protein conserved in bacteria
LAF_RS00425	COG0012	GTP binding
LAF_RS00435	COG0516	GMP reductase activity
LAF_RS00435	COG0517	IMP dehydrogenase activity
LAF_RS00445	COG3328	transposase activity
LAF_RS00450	COG1316	TRANSCRIPTIONal
LAF_RS00460	COG0489	protein tyrosine kinase activity
LAF_RS00470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LAF_RS00475	COG1216	Glycosyl transferase, family 2
LAF_RS00485	COG1215	transferase activity, transferring glycosyl groups
LAF_RS00485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LAF_RS00510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LAF_RS00520	COG1088	dTDP-glucose 4,6-dehydratase activity
LAF_RS00525	COG1091	dTDP-4-dehydrorhamnose reductase activity
LAF_RS00580	COG0745	RESPONSE REGULATOR receiver
LAF_RS00585	COG5002	protein histidine kinase activity
LAF_RS00590	COG1686	Belongs to the peptidase S11 family
LAF_RS00620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAF_RS00630	COG0628	permease
LAF_RS00635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LAF_RS00640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LAF_RS00645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LAF_RS00650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LAF_RS00670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LAF_RS00675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAF_RS00680	COG0047	phosphoribosylformylglycinamidine synthase activity
LAF_RS00685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAF_RS00695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LAF_RS00700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LAF_RS00705	COG0138	bifunctional purine biosynthesis protein purh
LAF_RS00710	COG0151	Belongs to the GarS family
LAF_RS00725	COG0588	phosphoglycerate mutase activity
LAF_RS00730	COG0436	Aminotransferase
LAF_RS00755	COG0477	Major facilitator Superfamily
LAF_RS00795	COG0596	Alpha beta hydrolase
LAF_RS00810	COG0583	DNA-binding transcription factor activity
LAF_RS00825	COG0667	Aldo Keto reductase
LAF_RS00835	COG0697	spore germination
LAF_RS00875	COG1120	ATPase activity
LAF_RS00880	COG0477	Major facilitator Superfamily
LAF_RS00895	COG0708	Exodeoxyribonuclease III
LAF_RS00920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LAF_RS00930	COG2508	Transcriptional regulator
LAF_RS00940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAF_RS00950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LAF_RS00980	COG1063	alcohol dehydrogenase
LAF_RS00990	COG0656	L-ascorbic acid biosynthetic process
LAF_RS01005	COG0778	Nitroreductase
LAF_RS01025	COG1464	Belongs to the NlpA lipoprotein family
LAF_RS01035	COG3973	AAA domain
LAF_RS01040	COG0248	Ppx GppA phosphatase
LAF_RS01055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LAF_RS01065	COG1801	Protein of unknown function DUF72
LAF_RS01070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAF_RS01070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAF_RS01075	COG0084	hydrolase, TatD family'
LAF_RS01080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LAF_RS01085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LAF_RS01090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LAF_RS01105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LAF_RS01110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAF_RS01115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LAF_RS01120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LAF_RS01130	COG0561	phosphatase activity
LAF_RS01135	COG1078	dGTPase activity
LAF_RS01145	COG3343	RNA polymerase activity
LAF_RS01150	COG0504	CTP synthase activity
LAF_RS01155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LAF_RS01160	COG0254	rRNA binding
LAF_RS01170	COG3764	Sortase (surface protein transpeptidase)
LAF_RS01180	COG1704	LemA family
LAF_RS01185	COG0501	Belongs to the peptidase M48B family
LAF_RS01190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAF_RS01200	COG0736	holo-[acyl-carrier-protein] synthase activity
LAF_RS01205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LAF_RS01210	COG2337	Toxic component of a toxin-antitoxin (TA) module
LAF_RS01220	COG0193	aminoacyl-tRNA hydrolase activity
LAF_RS01225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LAF_RS01230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LAF_RS01240	COG1098	S1 RNA binding domain
LAF_RS01245	COG0037	tRNA processing
LAF_RS01260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LAF_RS01265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAF_RS01270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LAF_RS01325	COG1002	Type II restriction enzyme, methylase subunits
LAF_RS01400	COG0582	viral genome integration into host DNA
LAF_RS01430	COG0477	Major facilitator Superfamily
LAF_RS01450	COG3104	oligopeptide transport
LAF_RS01475	COG1794	racemase activity, acting on amino acids and derivatives
LAF_RS01480	COG2188	Transcriptional regulator
LAF_RS01485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LAF_RS01490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LAF_RS01495	COG2183	response to ionizing radiation
LAF_RS01500	COG3091	SprT-like family
LAF_RS01510	COG3250	beta-galactosidase activity
LAF_RS01515	COG3250	beta-galactosidase activity
LAF_RS01525	COG0588	phosphoglycerate mutase activity
LAF_RS01530	COG0657	acetylesterase activity
LAF_RS01540	COG0110	maltose O-acetyltransferase activity
LAF_RS01555	COG0756	dUTP diphosphatase activity
LAF_RS01560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LAF_RS01565	COG4956	integral membrane protein (PIN domain superfamily)
LAF_RS01570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAF_RS01580	COG0215	cysteine-tRNA ligase activity
LAF_RS01585	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LAF_RS01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAF_RS01605	COG0250	Participates in transcription elongation, termination and antitermination
LAF_RS01610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LAF_RS01615	COG0081	regulation of translation
LAF_RS01620	COG0531	amino acid
LAF_RS01625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LAF_RS01630	COG0222	ribosome binding
LAF_RS01635	COG1271	oxidase subunit
LAF_RS01640	COG1294	oxidase, subunit
LAF_RS01645	COG4988	ABC transporter
LAF_RS01650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LAF_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
LAF_RS01655	COG1454	alcohol dehydrogenase
LAF_RS01660	COG1114	Component of the transport system for branched-chain amino acids
LAF_RS01665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAF_RS01670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAF_RS01675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LAF_RS01680	COG0590	tRNA wobble adenosine to inosine editing
LAF_RS01685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LAF_RS01690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LAF_RS01695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LAF_RS01705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LAF_RS01710	COG3870	Protein conserved in bacteria
LAF_RS01715	COG0470	DNA polymerase III
LAF_RS01720	COG4467	Involved in initiation control of chromosome replication
LAF_RS01740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LAF_RS01745	COG0248	Ppx GppA phosphatase
LAF_RS01750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAF_RS01760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LAF_RS01770	COG2235	arginine
LAF_RS01780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LAF_RS01785	COG0436	Aminotransferase
LAF_RS01790	COG1214	PFAM Peptidase M22, glycoprotease
LAF_RS01800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LAF_RS01815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LAF_RS01820	COG1846	Transcriptional regulator
LAF_RS01825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LAF_RS01835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LAF_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
LAF_RS01845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAF_RS01850	COG0511	ligase activity, forming carbon-carbon bonds
LAF_RS01860	COG0439	Biotin carboxylase
LAF_RS01865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LAF_RS01870	COG0825	malonyl-CoA metabolic process
LAF_RS01875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LAF_RS01880	COG1268	BioY protein
LAF_RS01890	COG0488	(ABC) transporter
LAF_RS01895	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LAF_RS01900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LAF_RS01905	COG0459	protein refolding
LAF_RS01910	COG0531	amino acid
LAF_RS01920	COG1739	Uncharacterized protein family UPF0029
LAF_RS01925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LAF_RS01940	COG0653	protein targeting
LAF_RS01945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LAF_RS01955	COG1950	PFAM Membrane protein of
LAF_RS01960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LAF_RS01965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LAF_RS01970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LAF_RS01980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LAF_RS01985	COG0436	Aminotransferase
LAF_RS01990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LAF_RS02005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LAF_RS02010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LAF_RS02015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LAF_RS02025	COG0561	phosphatase activity
LAF_RS02030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAF_RS02045	COG0556	nucleotide-excision repair
LAF_RS02050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LAF_RS02060	COG1660	Displays ATPase and GTPase activities
LAF_RS02065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LAF_RS02070	COG1481	regulation of sporulation
LAF_RS02075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LAF_RS02080	COG0740	serine-type endopeptidase activity
LAF_RS02100	COG0126	phosphoglycerate kinase activity
LAF_RS02105	COG0149	triose-phosphate isomerase activity
LAF_RS02110	COG0148	phosphopyruvate hydratase activity
LAF_RS02115	COG1113	amino acid transport
LAF_RS02130	COG0557	exoribonuclease II activity
LAF_RS02135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LAF_RS02145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LAF_RS02150	COG0280	phosphate acetyltransferase
LAF_RS02155	COG0802	atpase or kinase
LAF_RS02165	COG2176	DNA-directed DNA polymerase activity
LAF_RS02170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LAF_RS02185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAF_RS02190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LAF_RS02205	COG0561	phosphatase activity
LAF_RS02210	COG1388	LysM domain
LAF_RS02210	COG3942	CHAP domain
LAF_RS02215	COG2855	membrane
LAF_RS02220	COG0583	DNA-binding transcription factor activity
LAF_RS02230	COG1307	EDD domain protein, DegV family
LAF_RS02250	COG3715	PTS system
LAF_RS02255	COG3716	PTS system mannose fructose sorbose family IID component
LAF_RS02275	COG2801	Transposase and inactivated derivatives
LAF_RS02280	COG0745	RESPONSE REGULATOR receiver
LAF_RS02285	COG3850	Histidine kinase
LAF_RS02285	COG5002	protein histidine kinase activity
LAF_RS02290	COG4975	Glucose uptake
LAF_RS02310	COG2115	Belongs to the xylose isomerase family
LAF_RS02330	COG2211	Major facilitator Superfamily
LAF_RS02335	COG2801	Transposase and inactivated derivatives
LAF_RS02345	COG0450	alkyl hydroperoxide reductase
LAF_RS02375	COG0656	L-ascorbic acid biosynthetic process
LAF_RS02380	COG0149	triose-phosphate isomerase activity
LAF_RS02385	COG3527	Alpha-acetolactate decarboxylase
LAF_RS02420	COG1132	(ABC) transporter
LAF_RS02425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAF_RS02440	COG3442	glutamine amidotransferase
LAF_RS02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAF_RS02450	COG1435	thymidine kinase activity
LAF_RS02455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LAF_RS02460	COG2890	protein-(glutamine-N5) methyltransferase activity
LAF_RS02465	COG0009	L-threonylcarbamoyladenylate synthase
LAF_RS02470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LAF_RS02475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LAF_RS02490	COG2233	PERMEase
LAF_RS02495	COG0356	it plays a direct role in the translocation of protons across the membrane
LAF_RS02500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAF_RS02505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LAF_RS02510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAF_RS02515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LAF_RS02520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LAF_RS02525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LAF_RS02530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LAF_RS02540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LAF_RS02545	COG1077	Cell shape determining protein MreB Mrl
LAF_RS02555	COG0772	Belongs to the SEDS family
LAF_RS02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAF_RS02580	COG0589	response to stress
LAF_RS02590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LAF_RS02610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LAF_RS02630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LAF_RS02675	COG1061	Type III restriction enzyme res subunit
LAF_RS02825	COG1388	LysM domain
LAF_RS02825	COG3942	CHAP domain
LAF_RS02830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LAF_RS02835	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LAF_RS02840	COG1104	cysteine desulfurase activity
LAF_RS02845	COG0301	tRNA thio-modification
LAF_RS02850	COG2610	gluconate transmembrane transporter activity
LAF_RS02855	COG1929	Belongs to the glycerate kinase type-1 family
LAF_RS02885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LAF_RS02890	COG0525	valine-tRNA ligase activity
LAF_RS02895	COG0285	dihydrofolate synthase activity
LAF_RS02905	COG1077	Cell shape determining protein MreB Mrl
LAF_RS02910	COG1792	Involved in formation and maintenance of cell shape
LAF_RS02920	COG0765	amino acid transport
LAF_RS02925	COG1126	abc transporter atp-binding protein
LAF_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAF_RS02935	COG0612	Peptidase, M16
LAF_RS02940	COG0612	Peptidase, M16
LAF_RS02945	COG1426	Protein conserved in bacteria
LAF_RS02950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LAF_RS02955	COG1058	Belongs to the CinA family
LAF_RS02955	COG1546	Belongs to the CinA family
LAF_RS02960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LAF_RS02970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LAF_RS02975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LAF_RS02980	COG0632	four-way junction helicase activity
LAF_RS02985	COG2255	four-way junction helicase activity
LAF_RS03000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LAF_RS03005	COG0513	Belongs to the DEAD box helicase family
LAF_RS03010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LAF_RS03015	COG4472	Bacterial protein of unknown function (DUF965)
LAF_RS03020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LAF_RS03025	COG3906	Belongs to the UPF0473 family
LAF_RS03030	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LAF_RS03040	COG1193	negative regulation of DNA recombination
LAF_RS03045	COG3118	belongs to the thioredoxin family
LAF_RS03060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LAF_RS03065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LAF_RS03070	COG0622	Phosphoesterase
LAF_RS03075	COG0561	phosphatase activity
LAF_RS03080	COG0668	transmembrane transport
LAF_RS03095	COG0006	proline dipeptidase activity
LAF_RS03100	COG1609	Transcriptional regulator
LAF_RS03110	COG0217	transcriptional regulatory protein
LAF_RS03115	COG0791	NLP P60 protein
LAF_RS03115	COG1388	LysM domain
LAF_RS03120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LAF_RS03125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAF_RS03135	COG4537	Required for transformation and DNA binding
LAF_RS03155	COG0827	DNA restriction-modification system
LAF_RS03160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAF_RS03170	COG4470	Protein conserved in bacteria
LAF_RS03175	COG0647	UMP catabolic process
LAF_RS03185	COG0586	Pfam SNARE associated Golgi protein
LAF_RS03305	COG1393	Belongs to the ArsC family
LAF_RS03310	COG4862	establishment of competence for transformation
LAF_RS03325	COG2357	RelA SpoT domain protein
LAF_RS03330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LAF_RS03335	COG0564	pseudouridine synthase activity
LAF_RS03340	COG2706	6-phosphogluconolactonase activity
LAF_RS03345	COG0500	methyltransferase
LAF_RS03355	COG1674	ftsk spoiiie
LAF_RS03365	COG2001	Belongs to the MraZ family
LAF_RS03370	COG0275	rRNA processing
LAF_RS03380	COG0768	penicillin binding
LAF_RS03385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAF_RS03390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LAF_RS03395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LAF_RS03405	COG0849	cell division
LAF_RS03410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LAF_RS03415	COG1799	cell septum assembly
LAF_RS03430	COG3599	regulation of cell shape
LAF_RS03435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LAF_RS03440	COG1278	Cold shock
LAF_RS03455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LAF_RS03465	COG0482	sulfurtransferase activity
LAF_RS03480	COG0406	alpha-ribazole phosphatase activity
LAF_RS03490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LAF_RS03495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LAF_RS03500	COG1393	Belongs to the ArsC family
LAF_RS03505	COG1597	lipid kinase activity
LAF_RS03510	COG5503	Protein of unknown function (DUF1447)
LAF_RS03520	COG0242	peptide deformylase activity
LAF_RS03525	COG4476	Belongs to the UPF0223 family
LAF_RS03530	COG0483	inositol monophosphate 1-phosphatase activity
LAF_RS03535	COG1217	gtp-binding protein TYPA
LAF_RS03545	COG4471	UPF0298 protein
LAF_RS03550	COG0742	ribosomal rna small subunit methyltransferase
LAF_RS03555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LAF_RS03560	COG3480	Lon protease (S16) C-terminal proteolytic domain
LAF_RS03565	COG1555	photosystem II stabilization
LAF_RS03565	COG1596	polysaccharide export
LAF_RS03570	COG2131	deaminase
LAF_RS03575	COG2333	competence protein COMEC
LAF_RS03575	COG0658	competence protein
LAF_RS03580	COG1466	dna polymerase III delta subunit
LAF_RS03585	COG2826	transposase and inactivated derivatives, IS30 family
LAF_RS03590	COG0268	Binds directly to 16S ribosomal RNA
LAF_RS03595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LAF_RS03615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAF_RS03620	COG0544	peptidyl-prolyl cis-trans isomerase activity
LAF_RS03625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LAF_RS03630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAF_RS03640	COG1126	abc transporter atp-binding protein
LAF_RS03645	COG0322	excinuclease ABC activity
LAF_RS03650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LAF_RS03655	COG1234	tRNA 3'-trailer cleavage
LAF_RS03660	COG0300	oxidoreductase activity
LAF_RS03665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LAF_RS03665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LAF_RS03670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAF_RS03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAF_RS03695	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAF_RS03715	COG1396	sequence-specific DNA binding
LAF_RS03750	COG2814	Major facilitator Superfamily
LAF_RS03755	COG0367	asparagine synthase
LAF_RS03765	COG0675	Transposase, IS605 OrfB family
LAF_RS03825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LAF_RS03845	COG1396	sequence-specific DNA binding
LAF_RS03855	COG3645	SOS response
LAF_RS03855	COG3646	Phage regulatory protein
LAF_RS03895	COG0629	single-stranded DNA binding
LAF_RS03915	COG3328	transposase activity
LAF_RS03985	COG3328	transposase activity
LAF_RS03990	COG3328	transposase activity
LAF_RS04035	COG2801	Transposase and inactivated derivatives
LAF_RS04060	COG2801	Transposase and inactivated derivatives
LAF_RS04070	COG3328	transposase activity
LAF_RS04085	COG1857	crispr-associated protein
LAF_RS04100	COG1518	maintenance of DNA repeat elements
LAF_RS04105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAF_RS04170	COG3425	synthase
LAF_RS04175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LAF_RS04180	COG4224	UPF0291 protein
LAF_RS04185	COG3763	UPF0154 protein
LAF_RS04190	COG0204	Acyl-transferase
LAF_RS04195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LAF_RS04200	COG2827	Endonuclease containing a URI domain
LAF_RS04205	COG0052	Belongs to the universal ribosomal protein uS2 family
LAF_RS04210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LAF_RS04220	COG0233	cytoplasmic translational termination
LAF_RS04225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LAF_RS04230	COG4589	Belongs to the CDS family
LAF_RS04235	COG0750	zinc metalloprotease
LAF_RS04240	COG0442	prolyl-tRNA aminoacylation
LAF_RS04245	COG2176	DNA-directed DNA polymerase activity
LAF_RS04250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LAF_RS04255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LAF_RS04265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LAF_RS04270	COG0505	Belongs to the CarA family
LAF_RS04275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAF_RS04280	COG0779	Required for maturation of 30S ribosomal subunits
LAF_RS04285	COG0195	Participates in both transcription termination and antitermination
LAF_RS04290	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LAF_RS04300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LAF_RS04305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LAF_RS04310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LAF_RS04315	COG0196	riboflavin kinase activity
LAF_RS04320	COG2814	Major facilitator Superfamily
LAF_RS04380	COG3759	membrane
LAF_RS04390	COG3048	D-serine ammonia-lyase activity
LAF_RS04395	COG1113	amino acid transport
LAF_RS04405	COG2801	Transposase and inactivated derivatives
LAF_RS04415	COG1420	regulation of RNA biosynthetic process
LAF_RS04420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LAF_RS04425	COG0443	Heat shock 70 kDa protein
LAF_RS04430	COG0484	heat shock protein binding
LAF_RS04435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LAF_RS04440	COG0107	imidazoleglycerol-phosphate synthase activity
LAF_RS04445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LAF_RS04450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LAF_RS04455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LAF_RS04460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LAF_RS04465	COG0131	Imidazoleglycerol-phosphate dehydratase
LAF_RS04470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LAF_RS04475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LAF_RS04480	COG0107	imidazoleglycerol-phosphate synthase activity
LAF_RS04485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LAF_RS04490	COG0140	phosphoribosyl-ATP diphosphatase activity
LAF_RS04495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LAF_RS04500	COG0481	GTPase activity
LAF_RS04510	COG0406	alpha-ribazole phosphatase activity
LAF_RS04520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LAF_RS04525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LAF_RS04540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LAF_RS04550	COG0307	riboflavin synthase, alpha
LAF_RS04555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAF_RS04555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAF_RS04595	COG1874	Beta-galactosidase
LAF_RS04600	COG1609	Transcriptional regulator
LAF_RS04605	COG0783	Belongs to the Dps family
LAF_RS04625	COG2826	transposase and inactivated derivatives, IS30 family
LAF_RS04630	COG1104	cysteine desulfurase activity
LAF_RS04655	COG1811	Na channel or pump
LAF_RS04660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAF_RS04665	COG1464	Belongs to the NlpA lipoprotein family
LAF_RS04670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAF_RS04710	COG0351	phosphomethylpyrimidine kinase
LAF_RS04715	COG0352	thiamine-phosphate diphosphorylase activity
LAF_RS04720	COG0351	phosphomethylpyrimidine kinase
LAF_RS04725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LAF_RS04740	COG0039	L-malate dehydrogenase activity
LAF_RS04755	COG2264	protein methyltransferase activity
LAF_RS04760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LAF_RS04770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAF_RS04775	COG1490	D-aminoacyl-tRNA deacylase activity
LAF_RS04785	COG0626	cystathionine gamma-synthase activity
LAF_RS04790	COG0626	cystathionine gamma-synthase activity
LAF_RS04800	COG1126	abc transporter atp-binding protein
LAF_RS04805	COG0765	amino acid transport
LAF_RS04810	COG0765	amino acid transport
LAF_RS04820	COG0765	amino acid transport
LAF_RS04825	COG0765	amino acid transport
LAF_RS04830	COG1126	abc transporter atp-binding protein
LAF_RS04845	COG0460	homoserine dehydrogenase
LAF_RS04850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LAF_RS04855	COG0833	amino acid
LAF_RS04860	COG2040	homocysteine
LAF_RS04865	COG3001	Fructosamine kinase
LAF_RS04870	COG0860	N-Acetylmuramoyl-L-alanine amidase
LAF_RS04880	COG0124	histidyl-tRNA synthetase
LAF_RS04885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LAF_RS04895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LAF_RS04900	COG1610	YqeY-like protein
LAF_RS04905	COG1702	phosphate starvation-inducible protein PhoH
LAF_RS04910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LAF_RS04915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LAF_RS04920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LAF_RS04925	COG1381	Involved in DNA repair and RecF pathway recombination
LAF_RS04930	COG0752	glycyl-tRNA synthetase alpha subunit
LAF_RS04935	COG0751	glycine-tRNA ligase activity
LAF_RS04940	COG0358	DNA primase activity
LAF_RS04945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LAF_RS04950	COG2801	Transposase and inactivated derivatives
LAF_RS04975	COG2261	transglycosylase associated protein
LAF_RS04995	COG0527	aspartate kinase activity
LAF_RS05000	COG0019	diaminopimelate decarboxylase activity
LAF_RS05005	COG2171	N-acyltransferase activity
LAF_RS05010	COG1473	amidohydrolase
LAF_RS05015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LAF_RS05020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LAF_RS05025	COG0436	Aminotransferase
LAF_RS05030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LAF_RS05035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LAF_RS05040	COG0569	domain protein
LAF_RS05045	COG2384	SAM-dependent methyltransferase
LAF_RS05050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LAF_RS05055	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAF_RS05065	COG0587	DNA-directed DNA polymerase activity
LAF_RS05080	COG4974	Belongs to the 'phage' integrase family
LAF_RS05090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LAF_RS05095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LAF_RS05100	COG1187	pseudouridine synthase activity
LAF_RS05105	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LAF_RS05115	COG0514	ATP-dependent DNA helicase (RecQ)
LAF_RS05120	COG1388	LysM domain
LAF_RS05120	COG0791	NLP P60 protein
LAF_RS05125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LAF_RS05130	COG0539	negative regulation of cytoplasmic translation
LAF_RS05135	COG1160	GTP binding
LAF_RS05145	COG0457	Tetratricopeptide repeat
LAF_RS05155	COG0617	tRNA 3'-terminal CCA addition
LAF_RS05160	COG0488	(ABC) transporter
LAF_RS05165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LAF_RS05170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LAF_RS05175	COG1272	protein, Hemolysin III
LAF_RS05180	COG1307	EDD domain protein, DegV family
LAF_RS05185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAF_RS05195	COG2755	lipolytic protein G-D-S-L family
LAF_RS05200	COG4698	Protein conserved in bacteria
LAF_RS05205	COG4479	Belongs to the UPF0346 family
LAF_RS05215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LAF_RS05220	COG0758	DNA mediated transformation
LAF_RS05225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LAF_RS05240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LAF_RS05245	COG0187	DNA topoisomerase II activity
LAF_RS05250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LAF_RS05270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAF_RS05280	COG1956	GAF domain-containing protein
LAF_RS05290	COG0402	S-adenosylhomocysteine deaminase activity
LAF_RS05305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LAF_RS05310	COG1811	Na channel or pump
LAF_RS05315	COG2223	nitrite transmembrane transporter activity
LAF_RS05330	COG2814	Major facilitator Superfamily
LAF_RS05355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LAF_RS05360	COG0110	maltose O-acetyltransferase activity
LAF_RS05375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAF_RS05380	COG0477	Major facilitator Superfamily
LAF_RS05385	COG2423	ornithine cyclodeaminase activity
LAF_RS05430	COG0656	L-ascorbic acid biosynthetic process
LAF_RS05435	COG4720	Psort location CytoplasmicMembrane, score
LAF_RS05445	COG0538	isocitrate dehydrogenase activity
LAF_RS05455	COG4974	Belongs to the 'phage' integrase family
LAF_RS05460	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LAF_RS05465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LAF_RS05470	COG1063	alcohol dehydrogenase
LAF_RS05495	COG1732	Glycine betaine
LAF_RS05555	COG4221	oxidoreductase activity
LAF_RS05580	COG0066	3-isopropylmalate dehydratase activity
LAF_RS05585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LAF_RS05595	COG2814	Major facilitator Superfamily
LAF_RS05600	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LAF_RS05620	COG0318	PFAM AMP-dependent synthetase and ligase
LAF_RS05625	COG2271	Major facilitator Superfamily
LAF_RS05635	COG0626	cystathionine gamma-synthase activity
LAF_RS05640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LAF_RS05650	COG2848	UPF0210 protein
LAF_RS05680	COG2826	transposase and inactivated derivatives, IS30 family
LAF_RS05690	COG0697	spore germination
LAF_RS05700	COG1053	succinate dehydrogenase
LAF_RS05700	COG3976	FMN-binding domain protein
LAF_RS05705	COG0583	DNA-binding transcription factor activity
LAF_RS05715	COG0183	Belongs to the thiolase family
LAF_RS05720	COG0628	permease
LAF_RS05725	COG0730	response to heat
LAF_RS05730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LAF_RS05735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAF_RS05755	COG1250	3-hydroxyacyl-CoA dehydrogenase
LAF_RS05765	COG4690	dipeptidase activity
LAF_RS05775	COG2826	transposase and inactivated derivatives, IS30 family
LAF_RS05780	COG1113	amino acid transport
LAF_RS05790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LAF_RS05810	COG0105	UTP biosynthetic process
LAF_RS05815	COG1695	Transcriptional regulator
LAF_RS05820	COG3479	Phenolic acid decarboxylase
LAF_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAF_RS05845	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAF_RS05845	COG2918	glutathione biosynthetic process
LAF_RS05850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAF_RS05855	COG0402	S-adenosylhomocysteine deaminase activity
LAF_RS05860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAF_RS05880	COG0789	Transcriptional regulator
LAF_RS05885	COG0390	transport system, permease component
LAF_RS05890	COG4619	ABC transporter
LAF_RS05895	COG0028	Belongs to the TPP enzyme family
LAF_RS05915	COG3328	transposase activity
LAF_RS05950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LAF_RS05990	COG3682	Transcriptional regulator
LAF_RS05995	COG0582	viral genome integration into host DNA
LAF_RS06000	COG3328	transposase activity
LAF_RS06070	COG2610	gluconate transmembrane transporter activity
LAF_RS06075	COG1609	Transcriptional regulator
LAF_RS06085	COG0436	Aminotransferase
LAF_RS06105	COG0025	NhaP-type Na H and K H
LAF_RS06120	COG2181	nitrate reductase activity
LAF_RS06130	COG1140	nitrate reductase beta subunit
LAF_RS06135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LAF_RS06140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LAF_RS06155	COG0315	cyclic pyranopterin monophosphate synthase activity
LAF_RS06180	COG2197	response regulator
LAF_RS06205	COG2226	methyltransferase
LAF_RS06215	COG2151	metal-sulfur cluster biosynthetic enzyme
LAF_RS06220	COG2223	nitrite transmembrane transporter activity
LAF_RS06225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LAF_RS06245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAF_RS06250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LAF_RS06255	COG1252	NADH dehydrogenase
LAF_RS06260	COG2151	metal-sulfur cluster biosynthetic enzyme
LAF_RS06280	COG2826	transposase and inactivated derivatives, IS30 family
LAF_RS06290	COG0719	Fe-S assembly protein
LAF_RS06295	COG0822	iron-sulfur transferase activity
LAF_RS06300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LAF_RS06305	COG0719	Fe-S assembly protein
LAF_RS06335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAF_RS06340	COG0436	Aminotransferase
LAF_RS06345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LAF_RS06350	COG0287	Prephenate dehydrogenase
LAF_RS06355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LAF_RS06365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LAF_RS06370	COG0077	Prephenate dehydratase
LAF_RS06370	COG1605	Chorismate mutase
LAF_RS06375	COG0738	Major facilitator superfamily
LAF_RS06390	COG0561	phosphatase activity
LAF_RS06405	COG0477	Major facilitator Superfamily
LAF_RS06440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LAF_RS06445	COG1942	4-Oxalocrotonate Tautomerase
LAF_RS06450	COG0569	domain protein
LAF_RS06450	COG0475	glutathione-regulated potassium exporter activity
LAF_RS06465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAF_RS06470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LAF_RS06490	COG1253	flavin adenine dinucleotide binding
LAF_RS06495	COG2814	Major facilitator Superfamily
LAF_RS06510	COG0583	DNA-binding transcription factor activity
LAF_RS06520	COG0095	Lipoate-protein ligase
LAF_RS06545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LAF_RS06550	COG1687	branched-chain amino acid
LAF_RS06555	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LAF_RS06565	COG0460	homoserine dehydrogenase
LAF_RS06570	COG0083	homoserine kinase activity
LAF_RS06580	COG0702	epimerase
LAF_RS06585	COG1418	mRNA catabolic process
LAF_RS06590	COG3022	response to hydroperoxide
LAF_RS06600	COG1307	EDD domain protein, DegV family
LAF_RS06605	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LAF_RS06620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LAF_RS06625	COG0798	PFAM Bile acid sodium symporter
LAF_RS06640	COG0300	oxidoreductase activity
LAF_RS06645	COG0583	DNA-binding transcription factor activity
LAF_RS06655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAF_RS06660	COG0505	Belongs to the CarA family
LAF_RS06665	COG0564	pseudouridine synthase activity
LAF_RS06680	COG0328	RNA-DNA hybrid ribonuclease activity
LAF_RS06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAF_RS06695	COG0765	amino acid transport
LAF_RS06715	COG2801	Transposase and inactivated derivatives
LAF_RS06735	COG0154	amidase activity
LAF_RS06745	COG0116	Belongs to the methyltransferase superfamily
LAF_RS06750	COG1051	belongs to the nudix hydrolase family
LAF_RS06765	COG3599	regulation of cell shape
LAF_RS06770	COG4474	Belongs to the UPF0398 family
LAF_RS06775	COG3331	DNA recombination
LAF_RS06785	COG0697	spore germination
LAF_RS06790	COG0667	Aldo Keto reductase
LAF_RS06815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAF_RS06815	COG1199	ATP-dependent helicase activity
LAF_RS06840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAF_RS06845	COG3328	transposase activity
LAF_RS06855	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LAF_RS06855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAF_RS06860	COG0561	phosphatase activity
LAF_RS06865	COG0167	dihydroorotate dehydrogenase activity
LAF_RS06870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAF_RS06875	COG0505	Belongs to the CarA family
LAF_RS06880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LAF_RS06895	COG2801	Transposase and inactivated derivatives
LAF_RS06900	COG1518	maintenance of DNA repeat elements
LAF_RS06935	COG2801	Transposase and inactivated derivatives
LAF_RS06960	COG0335	large ribosomal subunit rRNA binding
LAF_RS06965	COG0531	amino acid
LAF_RS06970	COG0336	Belongs to the RNA methyltransferase TrmD family
LAF_RS06975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LAF_RS06980	COG1837	Belongs to the UPF0109 family
LAF_RS06985	COG0228	four-way junction DNA binding
LAF_RS06995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAF_RS07000	COG0581	inorganic phosphate transmembrane transporter activity
LAF_RS07005	COG0573	inorganic phosphate transmembrane transporter activity
LAF_RS07010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LAF_RS07015	COG0745	RESPONSE REGULATOR receiver
LAF_RS07035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LAF_RS07040	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LAF_RS07045	COG0552	protein localization to endoplasmic reticulum
LAF_RS07050	COG1196	nuclear chromosome segregation
LAF_RS07055	COG0571	ribonuclease III activity
LAF_RS07060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAF_RS07065	COG0416	fatty acid biosynthetic process
LAF_RS07070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LAF_RS07075	COG1461	Dihydroxyacetone kinase
LAF_RS07085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LAF_RS07090	COG1564	THIamine pyrophosphokinase
LAF_RS07095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LAF_RS07100	COG1162	GTPase activity
LAF_RS07105	COG0515	serine threonine protein kinase
LAF_RS07105	COG2815	serine threonine protein kinase
LAF_RS07115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAF_RS07115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAF_RS07120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LAF_RS07125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LAF_RS07130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LAF_RS07135	COG1758	RNA polymerase activity
LAF_RS07150	COG0497	DNA recombination
LAF_RS07155	COG1438	arginine binding
LAF_RS07160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LAF_RS07175	COG1570	exodeoxyribonuclease VII activity
LAF_RS07180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LAF_RS07185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAF_RS07190	COG1302	Protein conserved in bacteria
LAF_RS07195	COG0006	proline dipeptidase activity
LAF_RS07200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LAF_RS07210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LAF_RS07215	COG1309	transcriptional regulator
LAF_RS07245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LAF_RS07255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAF_RS07260	COG1940	carbohydrate kinase activity
LAF_RS07275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LAF_RS07280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LAF_RS07285	COG0768	penicillin binding
LAF_RS07295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAF_RS07300	COG0572	uridine kinase
LAF_RS07305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAF_RS07305	COG0072	phenylalanine-tRNA ligase activity
LAF_RS07310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LAF_RS07315	COG1733	regulation of RNA biosynthetic process
LAF_RS07325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAF_RS07330	COG1254	Belongs to the acylphosphatase family
LAF_RS07335	COG0706	membrane insertase activity
LAF_RS07340	COG0242	peptide deformylase activity
LAF_RS07350	COG5002	protein histidine kinase activity
LAF_RS07355	COG0745	RESPONSE REGULATOR receiver
LAF_RS07365	COG1323	Belongs to the UPF0348 family
LAF_RS07370	COG2226	methyltransferase
LAF_RS07375	COG0799	negative regulation of ribosome biogenesis
LAF_RS07385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LAF_RS07395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LAF_RS07415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LAF_RS07420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LAF_RS07425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LAF_RS07430	COG1484	DNA-dependent DNA replication
LAF_RS07440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LAF_RS07445	COG0237	dephospho-CoA kinase activity
LAF_RS07450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LAF_RS07465	COG0670	Belongs to the BI1 family
LAF_RS07470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAF_RS07475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAF_RS07480	COG3118	belongs to the thioredoxin family
LAF_RS07490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LAF_RS07500	COG1131	(ABC) transporter
LAF_RS07505	COG0537	adenosine 5'-monophosphoramidase activity
LAF_RS07520	COG3481	metal-dependent phosphohydrolase, HD sub domain
LAF_RS07525	COG3679	Belongs to the UPF0342 family
LAF_RS07530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAF_RS07535	COG0018	arginyl-trna synthetase
LAF_RS07555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LAF_RS07560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LAF_RS07570	COG0302	gtp cyclohydrolase
LAF_RS07575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LAF_RS07575	COG0302	gtp cyclohydrolase
LAF_RS07590	COG1609	Transcriptional regulator
LAF_RS07600	COG1428	Deoxynucleoside kinase
LAF_RS07605	COG1388	LysM domain
LAF_RS07605	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAF_RS07615	COG0589	response to stress
LAF_RS07620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAF_RS07625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LAF_RS07635	COG2244	polysaccharide biosynthetic process
LAF_RS07645	COG0495	leucyl-tRNA aminoacylation
LAF_RS07650	COG0671	phosphoesterase, PA-phosphatase related
LAF_RS07655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LAF_RS07660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LAF_RS07665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LAF_RS07675	COG2818	Glycosylase
LAF_RS07680	COG2814	Major facilitator Superfamily
LAF_RS07690	COG1113	amino acid transport
LAF_RS07720	COG1607	acyl-coa hydrolase
LAF_RS07735	COG2233	PERMEase
LAF_RS07745	COG0602	queuosine metabolic process
LAF_RS07755	COG0765	amino acid transport
LAF_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAF_RS07765	COG2076	Multidrug Resistance protein
LAF_RS07855	COG0438	transferase activity, transferring glycosyl groups
LAF_RS07860	COG0438	transferase activity, transferring glycosyl groups
LAF_RS07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LAF_RS07880	COG0542	response to heat
LAF_RS07890	COG1335	isochorismatase
LAF_RS07895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LAF_RS07910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LAF_RS07930	COG1131	(ABC) transporter
LAF_RS07935	COG2188	Transcriptional regulator
LAF_RS07940	COG1088	dTDP-glucose 4,6-dehydratase activity
LAF_RS07955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LAF_RS07970	COG0463	Glycosyl transferase, family 2
LAF_RS07975	COG0628	permease
LAF_RS07980	COG0463	Glycosyl transferase, family 2
LAF_RS07990	COG0791	NLP P60 protein
LAF_RS07995	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAF_RS08010	COG2801	Transposase and inactivated derivatives
LAF_RS08020	COG1216	Glycosyl transferase, family 2
LAF_RS08030	COG0562	UDP-galactopyranose mutase
LAF_RS08035	COG0438	transferase activity, transferring glycosyl groups
LAF_RS08065	COG2801	Transposase and inactivated derivatives
LAF_RS08095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LAF_RS08100	COG2137	regulation of response to DNA damage stimulus
LAF_RS08115	COG1295	ribonuclease BN
LAF_RS08120	COG1368	sulfuric ester hydrolase activity
LAF_RS08125	COG0024	Methionine aminopeptidase
LAF_RS08130	COG0716	FMN binding
LAF_RS08135	COG2246	polysaccharide biosynthetic process
LAF_RS08145	COG0513	Belongs to the DEAD box helicase family
LAF_RS08170	COG2918	glutathione biosynthetic process
LAF_RS08180	COG4841	protein insertion into membrane
LAF_RS08185	COG0488	(ABC) transporter
LAF_RS08190	COG0783	Belongs to the Dps family
LAF_RS08200	COG1316	TRANSCRIPTIONal
LAF_RS08205	COG1846	Transcriptional regulator
LAF_RS08215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LAF_RS08230	COG2226	methyltransferase
LAF_RS08250	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
LAF_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAF_RS08320	COG2801	Transposase and inactivated derivatives
LAF_RS08325	COG3328	transposase activity
LAF_RS08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAF_RS08370	COG3328	transposase activity
LAF_RS08375	COG3328	transposase activity
LAF_RS08380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAF_RS08385	COG1597	lipid kinase activity
LAF_RS08390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LAF_RS08395	COG0154	amidase activity
LAF_RS08400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LAF_RS08405	COG4851	CamS sex pheromone cAM373 precursor
LAF_RS08410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LAF_RS08425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAF_RS08430	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAF_RS08445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LAF_RS08450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LAF_RS08455	COG0101	tRNA pseudouridine synthase activity
LAF_RS08465	COG1122	ATPase activity
LAF_RS08470	COG1122	ATPase activity
LAF_RS08475	COG0203	ribosomal protein L17
LAF_RS08480	COG0202	RNA polymerase activity
LAF_RS08485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LAF_RS08490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LAF_RS08495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LAF_RS08500	COG0563	adenylate kinase activity
LAF_RS08510	COG0200	Binds to the 23S rRNA
LAF_RS08515	COG1841	ribosomal large subunit assembly
LAF_RS08520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LAF_RS08525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LAF_RS08530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LAF_RS08535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LAF_RS08540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LAF_RS08545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LAF_RS08550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LAF_RS08555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LAF_RS08565	COG0255	Belongs to the universal ribosomal protein uL29 family
LAF_RS08570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LAF_RS08575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LAF_RS08580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LAF_RS08585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LAF_RS08590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LAF_RS08595	COG0089	rRNA binding
LAF_RS08600	COG0088	Forms part of the polypeptide exit tunnel
LAF_RS08605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LAF_RS08610	COG0051	transcription antitermination factor activity, RNA binding
LAF_RS08615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LAF_RS08620	COG0049	tRNA binding
LAF_RS08625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LAF_RS08630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LAF_RS08640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LAF_RS08645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LAF_RS08650	COG0085	RNA polymerase activity
LAF_RS08660	COG0542	response to heat
LAF_RS08665	COG4463	regulation of RNA biosynthetic process
LAF_RS08670	COG1064	alcohol dehydrogenase
LAF_RS08690	COG0110	maltose O-acetyltransferase activity
LAF_RS08695	COG0789	Transcriptional regulator
LAF_RS08710	COG1968	undecaprenyl-diphosphatase activity
LAF_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
LAF_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
LAF_RS08750	COG1428	Deoxynucleoside kinase
LAF_RS08755	COG0833	amino acid
LAF_RS08785	COG1278	Cold shock
LAF_RS08840	COG2814	Major facilitator Superfamily
LAF_RS08850	COG2160	L-arabinose isomerase activity
LAF_RS08860	COG1609	Transcriptional regulator
LAF_RS08875	COG0564	pseudouridine synthase activity
LAF_RS08885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LAF_RS08885	COG0392	lysyltransferase activity
LAF_RS08890	COG0693	protein deglycase activity
LAF_RS08895	COG0657	acetylesterase activity
LAF_RS08910	COG0583	DNA-binding transcription factor activity
LAF_RS08920	COG3328	transposase activity
LAF_RS08950	COG2801	Transposase and inactivated derivatives
LAF_RS09015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAF_RS09015	COG2190	(PTS) system
LAF_RS09015	COG1263	PTS System
LAF_RS09035	COG0583	DNA-binding transcription factor activity
LAF_RS09040	COG2326	polyphosphate kinase activity
LAF_RS09060	COG1686	Belongs to the peptidase S11 family
LAF_RS09070	COG2706	6-phosphogluconolactonase activity
LAF_RS09090	COG0494	nUDIX hydrolase
LAF_RS09100	COG2814	Major facilitator Superfamily
LAF_RS09125	COG1854	S-ribosylhomocysteine lyase activity
LAF_RS09130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LAF_RS09140	COG2502	aspartate--ammonia ligase
LAF_RS09155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAF_RS09165	COG0789	Transcriptional regulator
LAF_RS09170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LAF_RS09175	COG1984	allophanate hydrolase subunit 2
LAF_RS09185	COG0439	Biotin carboxylase
LAF_RS09190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LAF_RS09195	COG1914	H( )-stimulated, divalent metal cation uptake system
LAF_RS09210	COG3118	belongs to the thioredoxin family
LAF_RS09240	COG0531	amino acid
LAF_RS09260	COG0165	Argininosuccinate lyase
LAF_RS09280	COG0577	efflux transmembrane transporter activity
LAF_RS09280	COG1136	(ABC) transporter
LAF_RS09295	COG1136	(ABC) transporter
LAF_RS09295	COG0577	efflux transmembrane transporter activity
LAF_RS09305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LAF_RS09310	COG0675	Transposase, IS605 OrfB family
LAF_RS09325	COG0393	Putative heavy-metal-binding
LAF_RS09335	COG2070	2-Nitropropane dioxygenase
LAF_RS09340	COG0640	Transcriptional regulator
LAF_RS09360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAF_RS09375	COG2357	RelA SpoT domain protein
LAF_RS09400	COG1072	(Pantothenic acid kinase))
LAF_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
LAF_RS09415	COG1368	sulfuric ester hydrolase activity
LAF_RS09425	COG3973	AAA domain
LAF_RS09430	COG0586	Pfam SNARE associated Golgi protein
LAF_RS09440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LAF_RS09445	COG4948	Mandelate Racemase Muconate Lactonizing
LAF_RS09455	COG0531	amino acid
LAF_RS09470	COG1511	domain protein
LAF_RS09480	COG2017	converts alpha-aldose to the beta-anomer
LAF_RS09495	COG0735	belongs to the Fur family
LAF_RS09500	COG0194	GDP metabolic process
LAF_RS09515	COG2936	dipeptidyl-peptidase activity
LAF_RS09520	COG2267	carboxylic ester hydrolase activity
LAF_RS09535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAF_RS09540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAF_RS09545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAF_RS09555	COG1376	ErfK ybiS ycfS ynhG family protein
LAF_RS09565	COG0488	(ABC) transporter
LAF_RS09575	COG4120	Belongs to the binding-protein-dependent transport system permease family
LAF_RS09580	COG3842	ATPase activity
LAF_RS09590	COG0004	ammonium transporteR
LAF_RS09595	COG0534	Mate efflux family protein
LAF_RS09600	COG1940	carbohydrate kinase activity
LAF_RS09610	COG1609	Transcriptional regulator
LAF_RS09615	COG2084	Dehydrogenase
LAF_RS09625	COG3118	belongs to the thioredoxin family
LAF_RS09630	COG0861	Integral membrane protein TerC family
LAF_RS09635	COG0564	pseudouridine synthase activity
LAF_RS09645	COG2233	PERMEase
LAF_RS09650	COG0702	epimerase
LAF_RS09655	COG0406	alpha-ribazole phosphatase activity
LAF_RS09660	COG1368	sulfuric ester hydrolase activity
LAF_RS09670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAF_RS09680	COG2608	mercury ion transmembrane transporter activity
LAF_RS09685	COG2217	Heavy metal translocating P-type atpase
LAF_RS09690	COG0492	ferredoxin-NADP+ reductase activity
LAF_RS09695	COG1957	nucleoside hydrolase
LAF_RS09705	COG1122	ATPase activity
LAF_RS09725	COG0095	Lipoate-protein ligase
LAF_RS09740	COG1396	sequence-specific DNA binding
LAF_RS09785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LAF_RS09795	COG2801	Transposase and inactivated derivatives
LAF_RS09800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LAF_RS09805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LAF_RS09825	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LAF_RS09830	COG1606	tRNA processing
LAF_RS09835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LAF_RS09840	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LAF_RS09845	COG1691	(AIR) carboxylase
LAF_RS09850	COG3875	lactate racemase activity
LAF_RS09855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAF_RS09880	COG1869	D-ribose catabolic process
LAF_RS09890	COG2390	Transcriptional regulator
LAF_RS09895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LAF_RS09905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAF_RS09910	COG3775	system Galactitol-specific IIC component
LAF_RS09915	COG1609	Transcriptional regulator
LAF_RS09935	COG0561	phosphatase activity
LAF_RS09940	COG2188	Transcriptional regulator
LAF_RS09945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LAF_RS09975	COG1253	flavin adenine dinucleotide binding
LAF_RS09990	COG2807	transmembrane transport
LAF_RS10000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LAF_RS10005	COG0589	response to stress
LAF_RS10010	COG1522	sequence-specific DNA binding
LAF_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
LAF_RS10020	COG1609	Transcriptional regulator
LAF_RS10025	COG1164	Oligoendopeptidase f
LAF_RS10030	COG1301	dicarboxylic acid transport
LAF_RS10050	COG0277	FAD linked oxidase domain protein
LAF_RS10055	COG3328	transposase activity
LAF_RS10060	COG0277	FAD linked oxidase domain protein
LAF_RS10070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LAF_RS10070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LAF_RS10080	COG2315	Protein conserved in bacteria
LAF_RS10100	COG2207	Transcriptional regulator
LAF_RS10115	COG3328	transposase activity
LAF_RS10120	COG1002	Type II restriction enzyme, methylase subunits
LAF_RS10190	COG0577	efflux transmembrane transporter activity
LAF_RS10195	COG3328	transposase activity
LAF_RS10225	COG1609	Transcriptional regulator
LAF_RS10230	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LAF_RS10235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LAF_RS10245	COG2365	Tyrosine phosphatase family
LAF_RS10250	COG1881	PFAM PEBP family protein
LAF_RS10260	COG1126	abc transporter atp-binding protein
LAF_RS10265	COG0765	amino acid transport
LAF_RS10270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAF_RS10280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAF_RS10285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAF_RS10295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LAF_RS10300	COG3590	peptidase
LAF_RS10305	COG2252	PERMEase
LAF_RS10325	COG2094	Belongs to the DNA glycosylase MPG family
LAF_RS10330	COG3189	MarR family transcriptional regulator
LAF_RS10340	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAF_RS10350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LAF_RS10355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAF_RS10370	COG1609	Transcriptional regulator
LAF_RS10375	COG1388	LysM domain
LAF_RS10375	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAF_RS10380	COG0640	Transcriptional regulator
LAF_RS10410	COG1063	alcohol dehydrogenase
LAF_RS10425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LAF_RS10450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LAF_RS10455	COG0367	asparagine synthase
LAF_RS10465	COG1970	mechanosensitive ion channel activity
LAF_RS10470	COG0445	tRNA wobble uridine modification
LAF_RS10475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LAF_RS10485	COG0706	membrane insertase activity
LAF_RS10490	COG0594	ribonuclease P activity