locus-tag	class	description
LF25067_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LF25067_RS00010	COG0592	DNA-directed DNA polymerase activity
LF25067_RS00015	COG2501	S4 domain
LF25067_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LF25067_RS00025	COG0187	DNA topoisomerase II activity
LF25067_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LF25067_RS00040	COG0629	single-stranded DNA binding
LF25067_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LF25067_RS00055	COG0359	binds to the 23S rRNA
LF25067_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LF25067_RS00090	COG0745	RESPONSE REGULATOR receiver
LF25067_RS00110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LF25067_RS00115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LF25067_RS00120	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LF25067_RS00125	COG1959	2 iron, 2 sulfur cluster binding
LF25067_RS00150	COG4152	abc transporter atp-binding protein
LF25067_RS00185	COG0436	Aminotransferase
LF25067_RS00205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LF25067_RS00210	COG1074	ATP-dependent DNA helicase activity
LF25067_RS00215	COG0656	L-ascorbic acid biosynthetic process
LF25067_RS00265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LF25067_RS00270	COG1012	belongs to the aldehyde dehydrogenase family
LF25067_RS00275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LF25067_RS00280	COG0284	orotidine-5'-phosphate decarboxylase activity
LF25067_RS00285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LF25067_RS00305	COG0438	transferase activity, transferring glycosyl groups
LF25067_RS00335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LF25067_RS00340	COG1114	Component of the transport system for branched-chain amino acids
LF25067_RS00345	COG0667	Aldo Keto reductase
LF25067_RS00350	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LF25067_RS00360	COG1696	Membrane protein involved in D-alanine export
LF25067_RS00365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LF25067_RS00380	COG0675	Transposase, IS605 OrfB family
LF25067_RS00385	COG0420	3'-5' exonuclease activity
LF25067_RS00390	COG0419	ATPase involved in DNA repair
LF25067_RS00395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LF25067_RS00410	COG3328	transposase activity
LF25067_RS00415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LF25067_RS00430	COG0675	Transposase, IS605 OrfB family
LF25067_RS00435	COG1113	amino acid transport
LF25067_RS00440	COG2826	transposase and inactivated derivatives, IS30 family
LF25067_RS00465	COG0765	amino acid transport
LF25067_RS00470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LF25067_RS00480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LF25067_RS00490	COG0357	Ribosomal RNA small subunit methyltransferase G
LF25067_RS00500	COG1475	DNA binding
LF25067_RS00505	COG4481	Protein conserved in bacteria
LF25067_RS00510	COG0012	GTP binding
LF25067_RS00520	COG0516	GMP reductase activity
LF25067_RS00520	COG0517	IMP dehydrogenase activity
LF25067_RS00525	COG1316	TRANSCRIPTIONal
LF25067_RS00535	COG0489	protein tyrosine kinase activity
LF25067_RS00555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LF25067_RS00560	COG3328	transposase activity
LF25067_RS00585	COG2801	Transposase and inactivated derivatives
LF25067_RS00605	COG0297	glycogen (starch) synthase activity
LF25067_RS00655	COG1045	serine acetyltransferase
LF25067_RS00680	COG0745	RESPONSE REGULATOR receiver
LF25067_RS00690	COG1686	Belongs to the peptidase S11 family
LF25067_RS00715	COG0675	Transposase, IS605 OrfB family
LF25067_RS00720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LF25067_RS00730	COG0628	permease
LF25067_RS00735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LF25067_RS00740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LF25067_RS00745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LF25067_RS00750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LF25067_RS00765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LF25067_RS00770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LF25067_RS00775	COG0047	phosphoribosylformylglycinamidine synthase activity
LF25067_RS00780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LF25067_RS00790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LF25067_RS00795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LF25067_RS00800	COG0138	bifunctional purine biosynthesis protein purh
LF25067_RS00805	COG0151	Belongs to the GarS family
LF25067_RS00810	COG0588	phosphoglycerate mutase activity
LF25067_RS00815	COG0436	Aminotransferase
LF25067_RS00835	COG2217	Heavy metal translocating P-type atpase
LF25067_RS00840	COG0477	Major facilitator Superfamily
LF25067_RS00900	COG0656	L-ascorbic acid biosynthetic process
LF25067_RS00925	COG0697	spore germination
LF25067_RS00935	COG0477	Major facilitator Superfamily
LF25067_RS00940	COG0708	Exodeoxyribonuclease III
LF25067_RS01010	COG0675	Transposase, IS605 OrfB family
LF25067_RS01015	COG0583	DNA-binding transcription factor activity
LF25067_RS01030	COG0778	Nitroreductase
LF25067_RS01040	COG1464	Belongs to the NlpA lipoprotein family
LF25067_RS01050	COG3973	AAA domain
LF25067_RS01055	COG0248	Ppx GppA phosphatase
LF25067_RS01070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LF25067_RS01080	COG1801	Protein of unknown function DUF72
LF25067_RS01085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF25067_RS01085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF25067_RS01090	COG0084	hydrolase, TatD family'
LF25067_RS01095	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LF25067_RS01100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LF25067_RS01105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LF25067_RS01115	COG1121	(ABC) transporter
LF25067_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LF25067_RS01125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF25067_RS01130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LF25067_RS01135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LF25067_RS01145	COG0561	phosphatase activity
LF25067_RS01150	COG1078	dGTPase activity
LF25067_RS01160	COG3343	RNA polymerase activity
LF25067_RS01165	COG0504	CTP synthase activity
LF25067_RS01170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LF25067_RS01175	COG0254	rRNA binding
LF25067_RS01185	COG3764	Sortase (surface protein transpeptidase)
LF25067_RS01190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LF25067_RS01195	COG1704	LemA family
LF25067_RS01200	COG0501	Belongs to the peptidase M48B family
LF25067_RS01205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LF25067_RS01215	COG0736	holo-[acyl-carrier-protein] synthase activity
LF25067_RS01220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LF25067_RS01225	COG2337	Toxic component of a toxin-antitoxin (TA) module
LF25067_RS01235	COG0193	aminoacyl-tRNA hydrolase activity
LF25067_RS01240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LF25067_RS01245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LF25067_RS01255	COG1098	S1 RNA binding domain
LF25067_RS01260	COG0037	tRNA processing
LF25067_RS01275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LF25067_RS01280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LF25067_RS01285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LF25067_RS01345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF25067_RS01365	COG0446	pyridine nucleotide-disulphide oxidoreductase
LF25067_RS01375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LF25067_RS01380	COG3328	transposase activity
LF25067_RS01400	COG2223	nitrite transmembrane transporter activity
LF25067_RS01425	COG3104	oligopeptide transport
LF25067_RS01450	COG1794	racemase activity, acting on amino acids and derivatives
LF25067_RS01455	COG2188	Transcriptional regulator
LF25067_RS01460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LF25067_RS01465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LF25067_RS01470	COG2183	response to ionizing radiation
LF25067_RS01475	COG3091	SprT-like family
LF25067_RS01485	COG3250	beta-galactosidase activity
LF25067_RS01490	COG3250	beta-galactosidase activity
LF25067_RS01500	COG0588	phosphoglycerate mutase activity
LF25067_RS01505	COG0657	acetylesterase activity
LF25067_RS01515	COG0110	maltose O-acetyltransferase activity
LF25067_RS01530	COG0756	dUTP diphosphatase activity
LF25067_RS01535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LF25067_RS01540	COG4956	integral membrane protein (PIN domain superfamily)
LF25067_RS01545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LF25067_RS01555	COG0215	cysteine-tRNA ligase activity
LF25067_RS01560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LF25067_RS01565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LF25067_RS01575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LF25067_RS01585	COG0250	Participates in transcription elongation, termination and antitermination
LF25067_RS01590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LF25067_RS01595	COG0081	regulation of translation
LF25067_RS01600	COG0531	amino acid
LF25067_RS01605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LF25067_RS01610	COG0222	ribosome binding
LF25067_RS01615	COG1271	oxidase subunit
LF25067_RS01620	COG1294	oxidase, subunit
LF25067_RS01625	COG4988	ABC transporter
LF25067_RS01630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LF25067_RS01635	COG1454	alcohol dehydrogenase
LF25067_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
LF25067_RS01640	COG1114	Component of the transport system for branched-chain amino acids
LF25067_RS01645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF25067_RS01650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF25067_RS01655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LF25067_RS01660	COG0590	tRNA wobble adenosine to inosine editing
LF25067_RS01670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LF25067_RS01675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LF25067_RS01680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LF25067_RS01690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LF25067_RS01695	COG3870	Protein conserved in bacteria
LF25067_RS01700	COG0470	DNA polymerase III
LF25067_RS01705	COG4467	Involved in initiation control of chromosome replication
LF25067_RS01725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LF25067_RS01730	COG0248	Ppx GppA phosphatase
LF25067_RS01735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LF25067_RS01745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LF25067_RS01755	COG2235	arginine
LF25067_RS01765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LF25067_RS01770	COG0436	Aminotransferase
LF25067_RS01775	COG1214	PFAM Peptidase M22, glycoprotease
LF25067_RS01785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LF25067_RS01795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LF25067_RS01805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LF25067_RS01810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LF25067_RS01815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LF25067_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
LF25067_RS01825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LF25067_RS01830	COG0511	ligase activity, forming carbon-carbon bonds
LF25067_RS01840	COG0439	Biotin carboxylase
LF25067_RS01845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LF25067_RS01850	COG0825	malonyl-CoA metabolic process
LF25067_RS01855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LF25067_RS01860	COG1268	BioY protein
LF25067_RS01870	COG0488	(ABC) transporter
LF25067_RS01875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LF25067_RS01880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LF25067_RS01885	COG0459	protein refolding
LF25067_RS01890	COG0531	amino acid
LF25067_RS01900	COG1739	Uncharacterized protein family UPF0029
LF25067_RS01905	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LF25067_RS01920	COG0653	protein targeting
LF25067_RS01935	COG1950	PFAM Membrane protein of
LF25067_RS01940	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LF25067_RS01945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LF25067_RS01950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LF25067_RS01960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LF25067_RS01965	COG0436	Aminotransferase
LF25067_RS01970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LF25067_RS01980	COG0492	ferredoxin-NADP+ reductase activity
LF25067_RS01985	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LF25067_RS01990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LF25067_RS02005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LF25067_RS02015	COG0561	phosphatase activity
LF25067_RS02020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LF25067_RS02035	COG0556	nucleotide-excision repair
LF25067_RS02040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LF25067_RS02050	COG1660	Displays ATPase and GTPase activities
LF25067_RS02055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LF25067_RS02060	COG1481	regulation of sporulation
LF25067_RS02070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LF25067_RS02075	COG0740	serine-type endopeptidase activity
LF25067_RS02090	COG2826	transposase and inactivated derivatives, IS30 family
LF25067_RS02105	COG0126	phosphoglycerate kinase activity
LF25067_RS02110	COG0149	triose-phosphate isomerase activity
LF25067_RS02115	COG0148	phosphopyruvate hydratase activity
LF25067_RS02120	COG1113	amino acid transport
LF25067_RS02135	COG0557	exoribonuclease II activity
LF25067_RS02140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LF25067_RS02150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LF25067_RS02155	COG0280	phosphate acetyltransferase
LF25067_RS02160	COG0802	atpase or kinase
LF25067_RS02170	COG2176	DNA-directed DNA polymerase activity
LF25067_RS02175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LF25067_RS02190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LF25067_RS02195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LF25067_RS02205	COG2755	lipolytic protein G-D-S-L family
LF25067_RS02205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LF25067_RS02210	COG0561	phosphatase activity
LF25067_RS02220	COG2855	membrane
LF25067_RS02225	COG0583	DNA-binding transcription factor activity
LF25067_RS02235	COG1307	EDD domain protein, DegV family
LF25067_RS02255	COG0675	Transposase, IS605 OrfB family
LF25067_RS02265	COG3715	PTS system
LF25067_RS02270	COG3716	PTS system mannose fructose sorbose family IID component
LF25067_RS02295	COG0745	RESPONSE REGULATOR receiver
LF25067_RS02300	COG3850	Histidine kinase
LF25067_RS02300	COG5002	protein histidine kinase activity
LF25067_RS02305	COG4975	Glucose uptake
LF25067_RS02315	COG0450	alkyl hydroperoxide reductase
LF25067_RS02350	COG0149	triose-phosphate isomerase activity
LF25067_RS02355	COG3527	Alpha-acetolactate decarboxylase
LF25067_RS02415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LF25067_RS02430	COG3442	glutamine amidotransferase
LF25067_RS02435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LF25067_RS02440	COG1435	thymidine kinase activity
LF25067_RS02445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LF25067_RS02450	COG2890	protein-(glutamine-N5) methyltransferase activity
LF25067_RS02455	COG0009	L-threonylcarbamoyladenylate synthase
LF25067_RS02460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LF25067_RS02465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LF25067_RS02485	COG0356	it plays a direct role in the translocation of protons across the membrane
LF25067_RS02490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LF25067_RS02495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LF25067_RS02500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LF25067_RS02505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LF25067_RS02510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LF25067_RS02515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LF25067_RS02520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LF25067_RS02530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LF25067_RS02535	COG1077	Cell shape determining protein MreB Mrl
LF25067_RS02540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LF25067_RS02550	COG0772	Belongs to the SEDS family
LF25067_RS02565	COG1181	Belongs to the D-alanine--D-alanine ligase family
LF25067_RS02575	COG0589	response to stress
LF25067_RS02585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LF25067_RS02605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LF25067_RS02625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LF25067_RS02630	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LF25067_RS02635	COG1104	cysteine desulfurase activity
LF25067_RS02640	COG0301	tRNA thio-modification
LF25067_RS02645	COG2610	gluconate transmembrane transporter activity
LF25067_RS02650	COG1929	Belongs to the glycerate kinase type-1 family
LF25067_RS02725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LF25067_RS02730	COG0525	valine-tRNA ligase activity
LF25067_RS02735	COG0285	dihydrofolate synthase activity
LF25067_RS02745	COG1077	Cell shape determining protein MreB Mrl
LF25067_RS02750	COG1792	Involved in formation and maintenance of cell shape
LF25067_RS02760	COG0765	amino acid transport
LF25067_RS02765	COG1126	abc transporter atp-binding protein
LF25067_RS02770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS02775	COG0612	Peptidase, M16
LF25067_RS02780	COG0612	Peptidase, M16
LF25067_RS02785	COG1426	Protein conserved in bacteria
LF25067_RS02790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LF25067_RS02795	COG1058	Belongs to the CinA family
LF25067_RS02795	COG1546	Belongs to the CinA family
LF25067_RS02800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LF25067_RS02810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LF25067_RS02815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LF25067_RS02820	COG0632	four-way junction helicase activity
LF25067_RS02825	COG2255	four-way junction helicase activity
LF25067_RS02840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LF25067_RS02845	COG0513	Belongs to the DEAD box helicase family
LF25067_RS02850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LF25067_RS02855	COG4472	Bacterial protein of unknown function (DUF965)
LF25067_RS02860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LF25067_RS02865	COG3906	Belongs to the UPF0473 family
LF25067_RS02870	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LF25067_RS02880	COG1193	negative regulation of DNA recombination
LF25067_RS02885	COG3118	belongs to the thioredoxin family
LF25067_RS02905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LF25067_RS02910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LF25067_RS02915	COG0622	Phosphoesterase
LF25067_RS02920	COG0561	phosphatase activity
LF25067_RS02925	COG0668	transmembrane transport
LF25067_RS02940	COG0006	proline dipeptidase activity
LF25067_RS02945	COG1609	Transcriptional regulator
LF25067_RS02955	COG0217	transcriptional regulatory protein
LF25067_RS02960	COG0791	NLP P60 protein
LF25067_RS02960	COG1388	LysM domain
LF25067_RS02970	COG3328	transposase activity
LF25067_RS02980	COG2801	Transposase and inactivated derivatives
LF25067_RS02990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LF25067_RS03000	COG4537	Required for transformation and DNA binding
LF25067_RS03020	COG0827	DNA restriction-modification system
LF25067_RS03025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LF25067_RS03035	COG4470	Protein conserved in bacteria
LF25067_RS03040	COG0647	UMP catabolic process
LF25067_RS03050	COG0586	Pfam SNARE associated Golgi protein
LF25067_RS03175	COG1393	Belongs to the ArsC family
LF25067_RS03180	COG4862	establishment of competence for transformation
LF25067_RS03200	COG2357	RelA SpoT domain protein
LF25067_RS03205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LF25067_RS03210	COG0564	pseudouridine synthase activity
LF25067_RS03215	COG2706	6-phosphogluconolactonase activity
LF25067_RS03220	COG0500	methyltransferase
LF25067_RS03230	COG1674	ftsk spoiiie
LF25067_RS03245	COG2001	Belongs to the MraZ family
LF25067_RS03250	COG0275	rRNA processing
LF25067_RS03260	COG0768	penicillin binding
LF25067_RS03265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LF25067_RS03270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LF25067_RS03275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LF25067_RS03285	COG0849	cell division
LF25067_RS03290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LF25067_RS03295	COG1799	cell septum assembly
LF25067_RS03310	COG3599	regulation of cell shape
LF25067_RS03315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LF25067_RS03320	COG1278	Cold shock
LF25067_RS03335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LF25067_RS03345	COG0482	sulfurtransferase activity
LF25067_RS03360	COG0406	alpha-ribazole phosphatase activity
LF25067_RS03370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LF25067_RS03375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LF25067_RS03380	COG1393	Belongs to the ArsC family
LF25067_RS03385	COG1597	lipid kinase activity
LF25067_RS03390	COG5503	Protein of unknown function (DUF1447)
LF25067_RS03400	COG0242	peptide deformylase activity
LF25067_RS03405	COG4476	Belongs to the UPF0223 family
LF25067_RS03410	COG0483	inositol monophosphate 1-phosphatase activity
LF25067_RS03415	COG1217	gtp-binding protein TYPA
LF25067_RS03425	COG4471	UPF0298 protein
LF25067_RS03430	COG0742	ribosomal rna small subunit methyltransferase
LF25067_RS03435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LF25067_RS03440	COG3480	Lon protease (S16) C-terminal proteolytic domain
LF25067_RS03450	COG1596	polysaccharide export
LF25067_RS03450	COG1555	photosystem II stabilization
LF25067_RS03455	COG2131	deaminase
LF25067_RS03460	COG2333	competence protein COMEC
LF25067_RS03460	COG0658	competence protein
LF25067_RS03465	COG1466	dna polymerase III delta subunit
LF25067_RS03470	COG0268	Binds directly to 16S ribosomal RNA
LF25067_RS03475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LF25067_RS03495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LF25067_RS03500	COG0544	peptidyl-prolyl cis-trans isomerase activity
LF25067_RS03505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LF25067_RS03510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LF25067_RS03520	COG1126	abc transporter atp-binding protein
LF25067_RS03525	COG0322	excinuclease ABC activity
LF25067_RS03530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LF25067_RS03535	COG1234	tRNA 3'-trailer cleavage
LF25067_RS03540	COG0300	oxidoreductase activity
LF25067_RS03545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LF25067_RS03545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LF25067_RS03550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF25067_RS03560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF25067_RS03565	COG3328	transposase activity
LF25067_RS03585	COG0367	asparagine synthase
LF25067_RS03600	COG1609	Transcriptional regulator
LF25067_RS03620	COG3328	transposase activity
LF25067_RS03635	COG0114	fumarate hydratase activity
LF25067_RS03640	COG1053	succinate dehydrogenase
LF25067_RS03650	COG0471	metal ion transport
LF25067_RS03670	COG0281	malic enzyme
LF25067_RS03680	COG3052	prosthetic group binding
LF25067_RS03700	COG2267	carboxylic ester hydrolase activity
LF25067_RS03720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LF25067_RS03755	COG2151	metal-sulfur cluster biosynthetic enzyme
LF25067_RS03770	COG3425	synthase
LF25067_RS03775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LF25067_RS03780	COG4224	UPF0291 protein
LF25067_RS03785	COG3763	UPF0154 protein
LF25067_RS03790	COG0204	Acyl-transferase
LF25067_RS03795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LF25067_RS03800	COG2827	Endonuclease containing a URI domain
LF25067_RS03805	COG0052	Belongs to the universal ribosomal protein uS2 family
LF25067_RS03810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LF25067_RS03820	COG0233	cytoplasmic translational termination
LF25067_RS03825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LF25067_RS03830	COG4589	Belongs to the CDS family
LF25067_RS03835	COG0750	zinc metalloprotease
LF25067_RS03840	COG0442	prolyl-tRNA aminoacylation
LF25067_RS03845	COG2176	DNA-directed DNA polymerase activity
LF25067_RS03855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LF25067_RS03860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LF25067_RS03865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LF25067_RS03870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LF25067_RS03875	COG0505	Belongs to the CarA family
LF25067_RS03880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LF25067_RS03885	COG0779	Required for maturation of 30S ribosomal subunits
LF25067_RS03890	COG0195	Participates in both transcription termination and antitermination
LF25067_RS03895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LF25067_RS03905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LF25067_RS03910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LF25067_RS03915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LF25067_RS03920	COG0196	riboflavin kinase activity
LF25067_RS03925	COG2814	Major facilitator Superfamily
LF25067_RS03930	COG3328	transposase activity
LF25067_RS03955	COG1420	regulation of RNA biosynthetic process
LF25067_RS03960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LF25067_RS03965	COG0443	Heat shock 70 kDa protein
LF25067_RS03970	COG0484	heat shock protein binding
LF25067_RS03980	COG0107	imidazoleglycerol-phosphate synthase activity
LF25067_RS03985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LF25067_RS03990	COG0140	phosphoribosyl-ATP diphosphatase activity
LF25067_RS03995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LF25067_RS04000	COG0481	GTPase activity
LF25067_RS04015	COG0406	alpha-ribazole phosphatase activity
LF25067_RS04020	COG0667	Aldo Keto reductase
LF25067_RS04025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LF25067_RS04050	COG1104	cysteine desulfurase activity
LF25067_RS04070	COG1811	Na channel or pump
LF25067_RS04075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LF25067_RS04080	COG1464	Belongs to the NlpA lipoprotein family
LF25067_RS04085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LF25067_RS04105	COG0351	phosphomethylpyrimidine kinase
LF25067_RS04135	COG0039	L-malate dehydrogenase activity
LF25067_RS04150	COG2264	protein methyltransferase activity
LF25067_RS04155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LF25067_RS04165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LF25067_RS04170	COG1490	D-aminoacyl-tRNA deacylase activity
LF25067_RS04180	COG0626	cystathionine gamma-synthase activity
LF25067_RS04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS04195	COG0456	acetyltransferase
LF25067_RS04200	COG0765	amino acid transport
LF25067_RS04205	COG1126	abc transporter atp-binding protein
LF25067_RS04210	COG1473	amidohydrolase
LF25067_RS04215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LF25067_RS04220	COG2079	MmgE PrpD family protein
LF25067_RS04225	COG0765	amino acid transport
LF25067_RS04230	COG0765	amino acid transport
LF25067_RS04235	COG1126	abc transporter atp-binding protein
LF25067_RS04250	COG0460	homoserine dehydrogenase
LF25067_RS04255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LF25067_RS04275	COG0675	Transposase, IS605 OrfB family
LF25067_RS04285	COG3001	Fructosamine kinase
LF25067_RS04290	COG0860	N-Acetylmuramoyl-L-alanine amidase
LF25067_RS04300	COG0124	histidyl-tRNA synthetase
LF25067_RS04305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LF25067_RS04320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LF25067_RS04325	COG1610	YqeY-like protein
LF25067_RS04330	COG1702	phosphate starvation-inducible protein PhoH
LF25067_RS04335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LF25067_RS04340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LF25067_RS04345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LF25067_RS04350	COG1381	Involved in DNA repair and RecF pathway recombination
LF25067_RS04355	COG0752	glycyl-tRNA synthetase alpha subunit
LF25067_RS04360	COG0751	glycine-tRNA ligase activity
LF25067_RS04365	COG0358	DNA primase activity
LF25067_RS04370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LF25067_RS04400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LF25067_RS04405	COG0527	aspartate kinase activity
LF25067_RS04410	COG0019	diaminopimelate decarboxylase activity
LF25067_RS04415	COG2171	N-acyltransferase activity
LF25067_RS04420	COG1473	amidohydrolase
LF25067_RS04425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LF25067_RS04430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LF25067_RS04435	COG0436	Aminotransferase
LF25067_RS04440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LF25067_RS04445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LF25067_RS04450	COG0569	domain protein
LF25067_RS04455	COG2384	SAM-dependent methyltransferase
LF25067_RS04460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LF25067_RS04465	COG2195	Cleaves the N-terminal amino acid of tripeptides
LF25067_RS04475	COG0587	DNA-directed DNA polymerase activity
LF25067_RS04485	COG2996	Protein conserved in bacteria
LF25067_RS04500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LF25067_RS04505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LF25067_RS04510	COG1187	pseudouridine synthase activity
LF25067_RS04515	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LF25067_RS04525	COG0514	ATP-dependent DNA helicase (RecQ)
LF25067_RS04535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LF25067_RS04540	COG0539	negative regulation of cytoplasmic translation
LF25067_RS04545	COG1160	GTP binding
LF25067_RS04555	COG0457	Tetratricopeptide repeat
LF25067_RS04565	COG0617	tRNA 3'-terminal CCA addition
LF25067_RS04570	COG0488	(ABC) transporter
LF25067_RS04575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LF25067_RS04580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LF25067_RS04585	COG1272	protein, Hemolysin III
LF25067_RS04590	COG1307	EDD domain protein, DegV family
LF25067_RS04595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF25067_RS04605	COG2755	lipolytic protein G-D-S-L family
LF25067_RS04610	COG4698	Protein conserved in bacteria
LF25067_RS04615	COG4479	Belongs to the UPF0346 family
LF25067_RS04625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LF25067_RS04630	COG0758	DNA mediated transformation
LF25067_RS04635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LF25067_RS04650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LF25067_RS04655	COG0187	DNA topoisomerase II activity
LF25067_RS04660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LF25067_RS04680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LF25067_RS04690	COG1956	GAF domain-containing protein
LF25067_RS04700	COG0402	S-adenosylhomocysteine deaminase activity
LF25067_RS04715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LF25067_RS04725	COG2223	nitrite transmembrane transporter activity
LF25067_RS04735	COG2814	Major facilitator Superfamily
LF25067_RS04765	COG0110	maltose O-acetyltransferase activity
LF25067_RS04770	COG0110	maltose O-acetyltransferase activity
LF25067_RS04780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF25067_RS04790	COG2423	ornithine cyclodeaminase activity
LF25067_RS04835	COG4720	Psort location CytoplasmicMembrane, score
LF25067_RS04845	COG0538	isocitrate dehydrogenase activity
LF25067_RS04855	COG4974	Belongs to the 'phage' integrase family
LF25067_RS04860	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LF25067_RS04870	COG1063	alcohol dehydrogenase
LF25067_RS04895	COG1732	Glycine betaine
LF25067_RS04920	COG0675	Transposase, IS605 OrfB family
LF25067_RS04960	COG4975	Glucose uptake
LF25067_RS04990	COG3328	transposase activity
LF25067_RS05070	COG0626	cystathionine gamma-synthase activity
LF25067_RS05075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LF25067_RS05085	COG2848	UPF0210 protein
LF25067_RS05115	COG0697	spore germination
LF25067_RS05125	COG1053	succinate dehydrogenase
LF25067_RS05125	COG3976	FMN-binding domain protein
LF25067_RS05140	COG0183	Belongs to the thiolase family
LF25067_RS05145	COG0628	permease
LF25067_RS05155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LF25067_RS05180	COG1250	3-hydroxyacyl-CoA dehydrogenase
LF25067_RS05190	COG4690	dipeptidase activity
LF25067_RS05200	COG1113	amino acid transport
LF25067_RS05210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LF25067_RS05225	COG0105	UTP biosynthetic process
LF25067_RS05230	COG1695	Transcriptional regulator
LF25067_RS05235	COG3479	Phenolic acid decarboxylase
LF25067_RS05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS05265	COG0402	S-adenosylhomocysteine deaminase activity
LF25067_RS05270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LF25067_RS05275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LF25067_RS05280	COG0584	glycerophosphoryl diester phosphodiesterase
LF25067_RS05290	COG0789	Transcriptional regulator
LF25067_RS05295	COG0390	transport system, permease component
LF25067_RS05300	COG4619	ABC transporter
LF25067_RS05305	COG0028	Belongs to the TPP enzyme family
LF25067_RS05380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LF25067_RS05410	COG0675	Transposase, IS605 OrfB family
LF25067_RS05435	COG3682	Transcriptional regulator
LF25067_RS05470	COG1609	Transcriptional regulator
LF25067_RS05480	COG0436	Aminotransferase
LF25067_RS05505	COG2226	methyltransferase
LF25067_RS05515	COG2151	metal-sulfur cluster biosynthetic enzyme
LF25067_RS05525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LF25067_RS05535	COG1252	NADH dehydrogenase
LF25067_RS05540	COG2151	metal-sulfur cluster biosynthetic enzyme
LF25067_RS05565	COG0719	Fe-S assembly protein
LF25067_RS05570	COG0822	iron-sulfur transferase activity
LF25067_RS05575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LF25067_RS05580	COG0719	Fe-S assembly protein
LF25067_RS05615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF25067_RS05620	COG0436	Aminotransferase
LF25067_RS05625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LF25067_RS05660	COG3104	oligopeptide transport
LF25067_RS05670	COG0561	phosphatase activity
LF25067_RS05720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LF25067_RS05725	COG1942	4-Oxalocrotonate Tautomerase
LF25067_RS05745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LF25067_RS05750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LF25067_RS05760	COG2814	Major facilitator Superfamily
LF25067_RS05770	COG1253	flavin adenine dinucleotide binding
LF25067_RS05775	COG2814	Major facilitator Superfamily
LF25067_RS05790	COG0095	Lipoate-protein ligase
LF25067_RS05835	COG0460	homoserine dehydrogenase
LF25067_RS05840	COG0083	homoserine kinase activity
LF25067_RS05850	COG0702	epimerase
LF25067_RS05855	COG1418	mRNA catabolic process
LF25067_RS05860	COG3022	response to hydroperoxide
LF25067_RS05870	COG1307	EDD domain protein, DegV family
LF25067_RS05875	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LF25067_RS05900	COG0300	oxidoreductase activity
LF25067_RS05915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LF25067_RS05920	COG0505	Belongs to the CarA family
LF25067_RS05925	COG0564	pseudouridine synthase activity
LF25067_RS05930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LF25067_RS05940	COG0328	RNA-DNA hybrid ribonuclease activity
LF25067_RS05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS05955	COG0765	amino acid transport
LF25067_RS05960	COG1216	Glycosyl transferase, family 2
LF25067_RS05960	COG1442	glycosyl transferase family 8
LF25067_RS05980	COG0154	amidase activity
LF25067_RS05985	COG1288	antiporter activity
LF25067_RS05990	COG0675	Transposase, IS605 OrfB family
LF25067_RS06000	COG0116	Belongs to the methyltransferase superfamily
LF25067_RS06005	COG1051	belongs to the nudix hydrolase family
LF25067_RS06025	COG3599	regulation of cell shape
LF25067_RS06030	COG4474	Belongs to the UPF0398 family
LF25067_RS06035	COG3331	DNA recombination
LF25067_RS06045	COG0697	spore germination
LF25067_RS06050	COG0667	Aldo Keto reductase
LF25067_RS06075	COG1199	ATP-dependent helicase activity
LF25067_RS06075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LF25067_RS06100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LF25067_RS06105	COG0581	inorganic phosphate transmembrane transporter activity
LF25067_RS06110	COG0573	inorganic phosphate transmembrane transporter activity
LF25067_RS06135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LF25067_RS06135	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LF25067_RS06140	COG0561	phosphatase activity
LF25067_RS06145	COG0167	dihydroorotate dehydrogenase activity
LF25067_RS06150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LF25067_RS06155	COG0505	Belongs to the CarA family
LF25067_RS06160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LF25067_RS06180	COG2801	Transposase and inactivated derivatives
LF25067_RS06185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LF25067_RS06190	COG1518	maintenance of DNA repeat elements
LF25067_RS06235	COG0335	large ribosomal subunit rRNA binding
LF25067_RS06240	COG0531	amino acid
LF25067_RS06245	COG0336	Belongs to the RNA methyltransferase TrmD family
LF25067_RS06250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LF25067_RS06255	COG1837	Belongs to the UPF0109 family
LF25067_RS06260	COG0228	four-way junction DNA binding
LF25067_RS06275	COG3328	transposase activity
LF25067_RS06285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LF25067_RS06295	COG1397	ADP-ribosylglycohydrolase
LF25067_RS06305	COG1335	isochorismatase
LF25067_RS06310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LF25067_RS06320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LF25067_RS06325	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LF25067_RS06330	COG0552	protein localization to endoplasmic reticulum
LF25067_RS06335	COG1196	nuclear chromosome segregation
LF25067_RS06340	COG0571	ribonuclease III activity
LF25067_RS06345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LF25067_RS06350	COG0416	fatty acid biosynthetic process
LF25067_RS06355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LF25067_RS06360	COG1461	Dihydroxyacetone kinase
LF25067_RS06370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LF25067_RS06375	COG1564	THIamine pyrophosphokinase
LF25067_RS06380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LF25067_RS06385	COG1162	GTPase activity
LF25067_RS06390	COG2815	serine threonine protein kinase
LF25067_RS06390	COG0515	serine threonine protein kinase
LF25067_RS06400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LF25067_RS06400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LF25067_RS06405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LF25067_RS06410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LF25067_RS06415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LF25067_RS06420	COG1758	RNA polymerase activity
LF25067_RS06440	COG0497	DNA recombination
LF25067_RS06445	COG1438	arginine binding
LF25067_RS06450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LF25067_RS06465	COG1570	exodeoxyribonuclease VII activity
LF25067_RS06470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LF25067_RS06475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LF25067_RS06480	COG1302	Protein conserved in bacteria
LF25067_RS06485	COG0006	proline dipeptidase activity
LF25067_RS06490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LF25067_RS06500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LF25067_RS06505	COG1309	transcriptional regulator
LF25067_RS06540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LF25067_RS06570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LF25067_RS06575	COG3328	transposase activity
LF25067_RS06620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LF25067_RS06630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LF25067_RS06635	COG1940	carbohydrate kinase activity
LF25067_RS06650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LF25067_RS06655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LF25067_RS06660	COG0768	penicillin binding
LF25067_RS06670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LF25067_RS06675	COG0572	uridine kinase
LF25067_RS06680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF25067_RS06680	COG0072	phenylalanine-tRNA ligase activity
LF25067_RS06685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LF25067_RS06690	COG1733	regulation of RNA biosynthetic process
LF25067_RS06700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LF25067_RS06705	COG1254	Belongs to the acylphosphatase family
LF25067_RS06710	COG0706	membrane insertase activity
LF25067_RS06715	COG0242	peptide deformylase activity
LF25067_RS06725	COG5002	protein histidine kinase activity
LF25067_RS06730	COG0745	RESPONSE REGULATOR receiver
LF25067_RS06735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LF25067_RS06745	COG1323	Belongs to the UPF0348 family
LF25067_RS06750	COG2226	methyltransferase
LF25067_RS06755	COG0799	negative regulation of ribosome biogenesis
LF25067_RS06765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LF25067_RS06775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LF25067_RS06795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LF25067_RS06800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LF25067_RS06805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LF25067_RS06810	COG1484	DNA-dependent DNA replication
LF25067_RS06820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LF25067_RS06825	COG0237	dephospho-CoA kinase activity
LF25067_RS06830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LF25067_RS06845	COG0670	Belongs to the BI1 family
LF25067_RS06850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LF25067_RS06855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LF25067_RS06860	COG3118	belongs to the thioredoxin family
LF25067_RS06870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LF25067_RS06880	COG1131	(ABC) transporter
LF25067_RS06885	COG0537	adenosine 5'-monophosphoramidase activity
LF25067_RS06900	COG3481	metal-dependent phosphohydrolase, HD sub domain
LF25067_RS06905	COG3679	Belongs to the UPF0342 family
LF25067_RS06910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LF25067_RS06915	COG0018	arginyl-trna synthetase
LF25067_RS06935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LF25067_RS06940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LF25067_RS06950	COG0302	gtp cyclohydrolase
LF25067_RS06955	COG0302	gtp cyclohydrolase
LF25067_RS06955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LF25067_RS06980	COG1428	Deoxynucleoside kinase
LF25067_RS06985	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF25067_RS06985	COG1388	LysM domain
LF25067_RS06995	COG0675	Transposase, IS605 OrfB family
LF25067_RS07010	COG0589	response to stress
LF25067_RS07015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LF25067_RS07020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LF25067_RS07030	COG2244	polysaccharide biosynthetic process
LF25067_RS07040	COG0495	leucyl-tRNA aminoacylation
LF25067_RS07045	COG0671	phosphoesterase, PA-phosphatase related
LF25067_RS07050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LF25067_RS07055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LF25067_RS07065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LF25067_RS07080	COG2814	Major facilitator Superfamily
LF25067_RS07090	COG1113	amino acid transport
LF25067_RS07120	COG1607	acyl-coa hydrolase
LF25067_RS07140	COG2233	PERMEase
LF25067_RS07150	COG0602	queuosine metabolic process
LF25067_RS07160	COG0765	amino acid transport
LF25067_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS07170	COG2076	Multidrug Resistance protein
LF25067_RS07185	COG2826	transposase and inactivated derivatives, IS30 family
LF25067_RS07270	COG0438	transferase activity, transferring glycosyl groups
LF25067_RS07275	COG0438	transferase activity, transferring glycosyl groups
LF25067_RS07280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LF25067_RS07295	COG0542	response to heat
LF25067_RS07305	COG1335	isochorismatase
LF25067_RS07310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LF25067_RS07325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LF25067_RS07345	COG1131	(ABC) transporter
LF25067_RS07350	COG2188	Transcriptional regulator
LF25067_RS07365	COG1215	transferase activity, transferring glycosyl groups
LF25067_RS07370	COG0438	transferase activity, transferring glycosyl groups
LF25067_RS07375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LF25067_RS07380	COG0463	Glycosyl transferase, family 2
LF25067_RS07385	COG0628	permease
LF25067_RS07390	COG0463	Glycosyl transferase, family 2
LF25067_RS07400	COG0791	NLP P60 protein
LF25067_RS07415	COG0446	pyridine nucleotide-disulphide oxidoreductase
LF25067_RS07440	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF25067_RS07455	COG0562	UDP-galactopyranose mutase
LF25067_RS07495	COG1295	ribonuclease BN
LF25067_RS07515	COG2801	Transposase and inactivated derivatives
LF25067_RS07525	COG0024	Methionine aminopeptidase
LF25067_RS07530	COG0716	FMN binding
LF25067_RS07535	COG2246	polysaccharide biosynthetic process
LF25067_RS07550	COG0513	Belongs to the DEAD box helicase family
LF25067_RS07575	COG2918	glutathione biosynthetic process
LF25067_RS07585	COG4841	protein insertion into membrane
LF25067_RS07590	COG0488	(ABC) transporter
LF25067_RS07595	COG2826	transposase and inactivated derivatives, IS30 family
LF25067_RS07615	COG1316	TRANSCRIPTIONal
LF25067_RS07620	COG1846	Transcriptional regulator
LF25067_RS07625	COG2223	nitrite transmembrane transporter activity
LF25067_RS07635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LF25067_RS07650	COG2226	methyltransferase
LF25067_RS07670	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
LF25067_RS07680	COG1757	Na H antiporter
LF25067_RS07685	COG0673	inositol 2-dehydrogenase activity
LF25067_RS07690	COG0675	Transposase, IS605 OrfB family
LF25067_RS07720	COG2723	6-phospho-beta-galactosidase activity
LF25067_RS07725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LF25067_RS07725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LF25067_RS07735	COG2315	Protein conserved in bacteria
LF25067_RS07750	COG3328	transposase activity
LF25067_RS07755	COG0477	Major facilitator Superfamily
LF25067_RS07760	COG0157	Belongs to the NadC ModD family
LF25067_RS07775	COG3328	transposase activity
LF25067_RS07785	COG1104	cysteine desulfurase activity
LF25067_RS07790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LF25067_RS07795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LF25067_RS07910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LF25067_RS07915	COG1597	lipid kinase activity
LF25067_RS07920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LF25067_RS07925	COG0154	amidase activity
LF25067_RS07930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LF25067_RS07935	COG4851	CamS sex pheromone cAM373 precursor
LF25067_RS07940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LF25067_RS07955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LF25067_RS07960	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF25067_RS07975	COG0675	Transposase, IS605 OrfB family
LF25067_RS07995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LF25067_RS08000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LF25067_RS08005	COG0101	tRNA pseudouridine synthase activity
LF25067_RS08015	COG1122	ATPase activity
LF25067_RS08020	COG1122	ATPase activity
LF25067_RS08025	COG0203	ribosomal protein L17
LF25067_RS08030	COG0202	RNA polymerase activity
LF25067_RS08035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LF25067_RS08040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LF25067_RS08045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LF25067_RS08050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LF25067_RS08055	COG0563	adenylate kinase activity
LF25067_RS08065	COG0200	Binds to the 23S rRNA
LF25067_RS08070	COG1841	ribosomal large subunit assembly
LF25067_RS08075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LF25067_RS08080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LF25067_RS08085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LF25067_RS08090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LF25067_RS08095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LF25067_RS08100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LF25067_RS08105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LF25067_RS08110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LF25067_RS08120	COG0255	Belongs to the universal ribosomal protein uL29 family
LF25067_RS08125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LF25067_RS08130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LF25067_RS08135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LF25067_RS08140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LF25067_RS08145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LF25067_RS08150	COG0089	rRNA binding
LF25067_RS08155	COG0088	Forms part of the polypeptide exit tunnel
LF25067_RS08160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LF25067_RS08165	COG0051	transcription antitermination factor activity, RNA binding
LF25067_RS08170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LF25067_RS08175	COG0049	tRNA binding
LF25067_RS08180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LF25067_RS08185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LF25067_RS08195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LF25067_RS08200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LF25067_RS08205	COG0085	RNA polymerase activity
LF25067_RS08215	COG0542	response to heat
LF25067_RS08220	COG4463	regulation of RNA biosynthetic process
LF25067_RS08230	COG1064	alcohol dehydrogenase
LF25067_RS08245	COG0110	maltose O-acetyltransferase activity
LF25067_RS08285	COG1968	undecaprenyl-diphosphatase activity
LF25067_RS08295	COG1028	Short-chain dehydrogenase reductase Sdr
LF25067_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
LF25067_RS08330	COG1428	Deoxynucleoside kinase
LF25067_RS08335	COG0833	amino acid
LF25067_RS08365	COG1278	Cold shock
LF25067_RS08435	COG0564	pseudouridine synthase activity
LF25067_RS08445	COG0392	lysyltransferase activity
LF25067_RS08445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LF25067_RS08450	COG0693	protein deglycase activity
LF25067_RS08455	COG0657	acetylesterase activity
LF25067_RS08480	COG0583	DNA-binding transcription factor activity
LF25067_RS08490	COG0431	NADPH-dependent FMN reductase
LF25067_RS08490	COG1053	succinate dehydrogenase
LF25067_RS08490	COG3976	FMN-binding domain protein
LF25067_RS08495	COG1053	succinate dehydrogenase
LF25067_RS08495	COG3976	FMN-binding domain protein
LF25067_RS08495	COG0431	NADPH-dependent FMN reductase
LF25067_RS08525	COG2190	(PTS) system
LF25067_RS08525	COG1263	PTS System
LF25067_RS08525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LF25067_RS08560	COG2326	polyphosphate kinase activity
LF25067_RS08580	COG1686	Belongs to the peptidase S11 family
LF25067_RS08590	COG2706	6-phosphogluconolactonase activity
LF25067_RS08610	COG0494	nUDIX hydrolase
LF25067_RS08635	COG3328	transposase activity
LF25067_RS08670	COG1854	S-ribosylhomocysteine lyase activity
LF25067_RS08675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LF25067_RS08680	COG1011	Hydrolase
LF25067_RS08685	COG2502	aspartate--ammonia ligase
LF25067_RS08700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LF25067_RS08710	COG0789	Transcriptional regulator
LF25067_RS08715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LF25067_RS08720	COG1984	allophanate hydrolase subunit 2
LF25067_RS08730	COG0439	Biotin carboxylase
LF25067_RS08735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LF25067_RS08740	COG1914	H( )-stimulated, divalent metal cation uptake system
LF25067_RS08765	COG3118	belongs to the thioredoxin family
LF25067_RS08785	COG0531	amino acid
LF25067_RS08795	COG0494	nUDIX hydrolase
LF25067_RS08805	COG0165	Argininosuccinate lyase
LF25067_RS08825	COG0640	Transcriptional regulator
LF25067_RS08845	COG3328	transposase activity
LF25067_RS08870	COG0519	Catalyzes the synthesis of GMP from XMP
LF25067_RS08890	COG1464	Belongs to the NlpA lipoprotein family
LF25067_RS08895	COG2011	ABC-type metal ion transport system permease component
LF25067_RS08900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LF25067_RS08905	COG1956	GAF domain-containing protein
LF25067_RS08920	COG0675	Transposase, IS605 OrfB family
LF25067_RS08940	COG1072	(Pantothenic acid kinase))
LF25067_RS08955	COG1368	sulfuric ester hydrolase activity
LF25067_RS08965	COG3973	AAA domain
LF25067_RS08970	COG0586	Pfam SNARE associated Golgi protein
LF25067_RS08980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LF25067_RS08985	COG0675	Transposase, IS605 OrfB family
LF25067_RS09005	COG0531	amino acid
LF25067_RS09020	COG3328	transposase activity
LF25067_RS09040	COG2017	converts alpha-aldose to the beta-anomer
LF25067_RS09055	COG0735	belongs to the Fur family
LF25067_RS09060	COG0194	GDP metabolic process
LF25067_RS09070	COG0531	amino acid
LF25067_RS09085	COG2936	dipeptidyl-peptidase activity
LF25067_RS09090	COG2267	carboxylic ester hydrolase activity
LF25067_RS09105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF25067_RS09110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF25067_RS09115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LF25067_RS09125	COG1376	ErfK ybiS ycfS ynhG family protein
LF25067_RS09145	COG4120	Belongs to the binding-protein-dependent transport system permease family
LF25067_RS09160	COG0004	ammonium transporteR
LF25067_RS09165	COG0534	Mate efflux family protein
LF25067_RS09170	COG1940	carbohydrate kinase activity
LF25067_RS09180	COG1609	Transcriptional regulator
LF25067_RS09185	COG2084	Dehydrogenase
LF25067_RS09215	COG3118	belongs to the thioredoxin family
LF25067_RS09220	COG0861	Integral membrane protein TerC family
LF25067_RS09225	COG0564	pseudouridine synthase activity
LF25067_RS09240	COG2233	PERMEase
LF25067_RS09245	COG2801	Transposase and inactivated derivatives
LF25067_RS09260	COG0588	phosphoglycerate mutase activity
LF25067_RS09265	COG1368	sulfuric ester hydrolase activity
LF25067_RS09275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LF25067_RS09285	COG2217	Heavy metal translocating P-type atpase
LF25067_RS09290	COG2217	Heavy metal translocating P-type atpase
LF25067_RS09295	COG0492	ferredoxin-NADP+ reductase activity
LF25067_RS09300	COG1957	nucleoside hydrolase
LF25067_RS09310	COG1122	ATPase activity
LF25067_RS09325	COG0025	NhaP-type Na H and K H
LF25067_RS09350	COG1396	sequence-specific DNA binding
LF25067_RS09370	COG0589	response to stress
LF25067_RS09390	COG3328	transposase activity
LF25067_RS09415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LF25067_RS09420	COG3775	system Galactitol-specific IIC component
LF25067_RS09425	COG1609	Transcriptional regulator
LF25067_RS09445	COG0561	phosphatase activity
LF25067_RS09450	COG2188	Transcriptional regulator
LF25067_RS09455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LF25067_RS09485	COG1253	flavin adenine dinucleotide binding
LF25067_RS09500	COG2807	transmembrane transport
LF25067_RS09510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LF25067_RS09515	COG0589	response to stress
LF25067_RS09525	COG1522	sequence-specific DNA binding
LF25067_RS09535	COG1609	Transcriptional regulator
LF25067_RS09540	COG1164	Oligoendopeptidase f
LF25067_RS09545	COG1301	dicarboxylic acid transport
LF25067_RS09565	COG1609	Transcriptional regulator
LF25067_RS09570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LF25067_RS09575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LF25067_RS09585	COG2365	Tyrosine phosphatase family
LF25067_RS09590	COG1881	PFAM PEBP family protein
LF25067_RS09600	COG1126	abc transporter atp-binding protein
LF25067_RS09605	COG0765	amino acid transport
LF25067_RS09610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LF25067_RS09620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LF25067_RS09625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LF25067_RS09635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LF25067_RS09640	COG3590	peptidase
LF25067_RS09645	COG2252	PERMEase
LF25067_RS09665	COG2094	Belongs to the DNA glycosylase MPG family
LF25067_RS09670	COG3189	MarR family transcriptional regulator
LF25067_RS09680	COG2249	NAD(P)H dehydrogenase (quinone) activity
LF25067_RS09690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LF25067_RS09695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LF25067_RS09715	COG1388	LysM domain
LF25067_RS09715	COG1705	Flagellar rod assembly protein muramidase FlgJ
LF25067_RS09725	COG0640	Transcriptional regulator
LF25067_RS09755	COG0675	Transposase, IS605 OrfB family
LF25067_RS09760	COG3328	transposase activity
LF25067_RS09780	COG1914	H( )-stimulated, divalent metal cation uptake system
LF25067_RS09790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LF25067_RS09815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LF25067_RS09820	COG0367	asparagine synthase
LF25067_RS09825	COG0833	amino acid
LF25067_RS09830	COG1970	mechanosensitive ion channel activity
LF25067_RS09835	COG0445	tRNA wobble uridine modification
LF25067_RS09840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LF25067_RS09850	COG0706	membrane insertase activity
LF25067_RS09855	COG0594	ribonuclease P activity
LF25067_RS09860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LF25067_RS09915	COG1192	Involved in chromosome partitioning
LF25067_RS09985	COG0662	Cupin 2, conserved barrel domain protein
LF25067_RS10050	COG1192	Involved in chromosome partitioning
LF25067_RS10070	COG2217	Heavy metal translocating P-type atpase
LF25067_RS10110	COG0662	Cupin 2, conserved barrel domain protein
LF25067_RS10175	COG1192	Involved in chromosome partitioning
LF25067_RS10195	COG2217	Heavy metal translocating P-type atpase