locus-tag	class	description
LGAS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LGAS_RS00010	COG0592	DNA-directed DNA polymerase activity
LGAS_RS00015	COG2501	S4 domain
LGAS_RS00025	COG0187	DNA topoisomerase II activity
LGAS_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LGAS_RS00040	COG0629	single-stranded DNA binding
LGAS_RS00060	COG0359	binds to the 23S rRNA
LGAS_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
LGAS_RS00070	COG1940	carbohydrate kinase activity
LGAS_RS00085	COG1285	pathogenesis
LGAS_RS00100	COG3800	Transcriptional regulator
LGAS_RS00100	COG1396	sequence-specific DNA binding
LGAS_RS00110	COG4989	oxidoreductase activity
LGAS_RS00135	COG1011	Hydrolase
LGAS_RS00140	COG1307	EDD domain protein, DegV family
LGAS_RS00160	COG2261	transglycosylase associated protein
LGAS_RS00165	COG0708	Exodeoxyribonuclease III
LGAS_RS00185	COG0628	permease
LGAS_RS00195	COG0516	GMP reductase activity
LGAS_RS00195	COG0517	IMP dehydrogenase activity
LGAS_RS00205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LGAS_RS00225	COG0531	amino acid
LGAS_RS00235	COG1053	succinate dehydrogenase
LGAS_RS00235	COG3976	FMN-binding domain protein
LGAS_RS00240	COG1114	Component of the transport system for branched-chain amino acids
LGAS_RS00245	COG2226	methyltransferase
LGAS_RS00250	COG2267	carboxylic ester hydrolase activity
LGAS_RS00310	COG0745	RESPONSE REGULATOR receiver
LGAS_RS00315	COG5002	protein histidine kinase activity
LGAS_RS00330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LGAS_RS00335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LGAS_RS00350	COG1122	ATPase activity
LGAS_RS00365	COG0501	Belongs to the peptidase M48B family
LGAS_RS00370	COG1704	LemA family
LGAS_RS00375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LGAS_RS00390	COG1215	transferase activity, transferring glycosyl groups
LGAS_RS00395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LGAS_RS00410	COG1126	abc transporter atp-binding protein
LGAS_RS00415	COG0765	amino acid transport
LGAS_RS00420	COG2094	Belongs to the DNA glycosylase MPG family
LGAS_RS00425	COG3189	MarR family transcriptional regulator
LGAS_RS00430	COG0861	Integral membrane protein TerC family
LGAS_RS00435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGAS_RS00440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LGAS_RS00450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LGAS_RS00455	COG2738	Putative neutral zinc metallopeptidase
LGAS_RS00465	COG0328	RNA-DNA hybrid ribonuclease activity
LGAS_RS00475	COG1216	Glycosyl transferase, family 2
LGAS_RS00480	COG2267	carboxylic ester hydrolase activity
LGAS_RS00490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LGAS_RS00500	COG1113	amino acid transport
LGAS_RS00530	COG0025	NhaP-type Na H and K H
LGAS_RS00555	COG2188	Transcriptional regulator
LGAS_RS00560	COG2222	sugar isomerase
LGAS_RS00570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS00580	COG3716	PTS system mannose fructose sorbose family IID component
LGAS_RS00585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGAS_RS00585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS00605	COG3613	nucleoside 2-deoxyribosyltransferase
LGAS_RS00615	COG2188	Transcriptional regulator
LGAS_RS00620	COG2365	Tyrosine phosphatase family
LGAS_RS00625	COG0589	response to stress
LGAS_RS00645	COG3639	organic phosphonate transmembrane transporter activity
LGAS_RS00660	COG0367	asparagine synthase
LGAS_RS00675	COG1328	CTP reductase activity
LGAS_RS00680	COG0602	queuosine metabolic process
LGAS_RS00685	COG2151	metal-sulfur cluster biosynthetic enzyme
LGAS_RS00705	COG2814	Major facilitator Superfamily
LGAS_RS00710	COG3684	Belongs to the aldolase LacD family
LGAS_RS00730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGAS_RS00730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGAS_RS00730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGAS_RS00735	COG3590	peptidase
LGAS_RS00745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LGAS_RS00775	COG1388	LysM domain
LGAS_RS00775	COG1705	Flagellar rod assembly protein muramidase FlgJ
LGAS_RS00785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LGAS_RS00790	COG0475	glutathione-regulated potassium exporter activity
LGAS_RS00790	COG0569	domain protein
LGAS_RS00795	COG0673	inositol 2-dehydrogenase activity
LGAS_RS00815	COG0588	phosphoglycerate mutase activity
LGAS_RS00820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LGAS_RS00840	COG4975	Glucose uptake
LGAS_RS00850	COG1316	TRANSCRIPTIONal
LGAS_RS00855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LGAS_RS00860	COG1368	sulfuric ester hydrolase activity
LGAS_RS00865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LGAS_RS00875	COG3579	cysteine-type endopeptidase activity
LGAS_RS00880	COG1418	mRNA catabolic process
LGAS_RS00895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LGAS_RS00905	COG2723	6-phospho-beta-galactosidase activity
LGAS_RS00915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS00920	COG2188	Transcriptional regulator
LGAS_RS00930	COG2723	6-phospho-beta-galactosidase activity
LGAS_RS00935	COG2188	Transcriptional regulator
LGAS_RS00940	COG1447	Phosphotransferase system cellobiose-specific component IIA
LGAS_RS00950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS00955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS00960	COG2723	6-phospho-beta-galactosidase activity
LGAS_RS00965	COG1940	carbohydrate kinase activity
LGAS_RS00980	COG2135	peptidase activity
LGAS_RS00990	COG2131	deaminase
LGAS_RS01000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGAS_RS01005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LGAS_RS01005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LGAS_RS01010	COG0084	hydrolase, TatD family'
LGAS_RS01020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LGAS_RS01025	COG4466	Protein conserved in bacteria
LGAS_RS01030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LGAS_RS01040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LGAS_RS01045	COG1609	Transcriptional regulator
LGAS_RS01050	COG0366	Alpha amylase catalytic
LGAS_RS01065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGAS_RS01070	COG3842	ATPase activity
LGAS_RS01075	COG1653	transport
LGAS_RS01080	COG1175	transmembrane transport
LGAS_RS01085	COG3833	ABC-type maltose transport systems, permease component
LGAS_RS01090	COG0366	Alpha amylase catalytic
LGAS_RS01095	COG1078	dGTPase activity
LGAS_RS01105	COG3343	RNA polymerase activity
LGAS_RS01110	COG0504	CTP synthase activity
LGAS_RS01115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LGAS_RS01120	COG2233	PERMEase
LGAS_RS01145	COG1395	domain, Protein
LGAS_RS01160	COG1309	transcriptional regulator
LGAS_RS01195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LGAS_RS01205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LGAS_RS01210	COG0028	Belongs to the TPP enzyme family
LGAS_RS01215	COG0679	Auxin Efflux Carrier
LGAS_RS01225	COG0148	phosphopyruvate hydratase activity
LGAS_RS01230	COG0148	phosphopyruvate hydratase activity
LGAS_RS01250	COG4690	dipeptidase activity
LGAS_RS01270	COG4120	Belongs to the binding-protein-dependent transport system permease family
LGAS_RS01280	COG0531	amino acid
LGAS_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LGAS_RS01300	COG0736	holo-[acyl-carrier-protein] synthase activity
LGAS_RS01315	COG0039	L-malate dehydrogenase activity
LGAS_RS01325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LGAS_RS01330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LGAS_RS01360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LGAS_RS01365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LGAS_RS01370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LGAS_RS01385	COG0542	response to heat
LGAS_RS01465	COG0255	Belongs to the universal ribosomal protein uL29 family
LGAS_RS01535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LGAS_RS01570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LGAS_RS01575	COG0101	tRNA pseudouridine synthase activity
LGAS_RS01580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LGAS_RS01610	COG0640	Transcriptional regulator
LGAS_RS01630	COG0588	phosphoglycerate mutase activity
LGAS_RS01645	COG0756	dUTP diphosphatase activity
LGAS_RS01665	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LGAS_RS01670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LGAS_RS01680	COG1447	Phosphotransferase system cellobiose-specific component IIA
LGAS_RS01685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS01685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS01690	COG2723	6-phospho-beta-galactosidase activity
LGAS_RS01705	COG1070	Carbohydrate kinase
LGAS_RS01710	COG1929	Belongs to the glycerate kinase type-1 family
LGAS_RS01725	COG0142	geranyltranstransferase activity
LGAS_RS01740	COG0250	Participates in transcription elongation, termination and antitermination
LGAS_RS01745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LGAS_RS01755	COG0765	amino acid transport
LGAS_RS01760	COG1126	abc transporter atp-binding protein
LGAS_RS01765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGAS_RS01770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LGAS_RS01790	COG2813	Specifically methylates the guanine in position
LGAS_RS01800	COG0590	tRNA wobble adenosine to inosine editing
LGAS_RS01805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LGAS_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LGAS_RS01830	COG3870	Protein conserved in bacteria
LGAS_RS01855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LGAS_RS01860	COG1214	PFAM Peptidase M22, glycoprotease
LGAS_RS01920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LGAS_RS01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS01955	COG2190	(PTS) system
LGAS_RS01955	COG1263	PTS System
LGAS_RS01960	COG1621	beta-fructofuranosidase activity
LGAS_RS01975	COG0488	(ABC) transporter
LGAS_RS02040	COG1862	Preprotein translocase
LGAS_RS02045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LGAS_RS02050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LGAS_RS02055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LGAS_RS02060	COG0513	Belongs to the DEAD box helicase family
LGAS_RS02095	COG3118	belongs to the thioredoxin family
LGAS_RS02100	COG1719	4-vinyl reductase, 4VR
LGAS_RS02105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LGAS_RS02110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LGAS_RS02115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LGAS_RS02120	COG0668	transmembrane transport
LGAS_RS02135	COG0006	proline dipeptidase activity
LGAS_RS02145	COG1132	(ABC) transporter
LGAS_RS02160	COG0584	glycerophosphoryl diester phosphodiesterase
LGAS_RS02170	COG0737	Belongs to the 5'-nucleotidase family
LGAS_RS02180	COG0647	UMP catabolic process
LGAS_RS02190	COG0586	Pfam SNARE associated Golgi protein
LGAS_RS02200	COG1098	S1 RNA binding domain
LGAS_RS02240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LGAS_RS02245	COG0477	Major facilitator Superfamily
LGAS_RS02260	COG2244	polysaccharide biosynthetic process
LGAS_RS02275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LGAS_RS02280	COG1376	ErfK ybiS ycfS ynhG family protein
LGAS_RS02285	COG1686	Belongs to the peptidase S11 family
LGAS_RS02290	COG0018	arginyl-trna synthetase
LGAS_RS02305	COG0519	Catalyzes the synthesis of GMP from XMP
LGAS_RS02330	COG1956	GAF domain-containing protein
LGAS_RS02340	COG0519	Catalyzes the synthesis of GMP from XMP
LGAS_RS02355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LGAS_RS02360	COG2814	Major facilitator Superfamily
LGAS_RS02365	COG2814	Major facilitator Superfamily
LGAS_RS02375	COG4716	Myosin-crossreactive antigen
LGAS_RS02380	COG0456	acetyltransferase
LGAS_RS02385	COG0561	phosphatase activity
LGAS_RS02395	COG0561	phosphatase activity
LGAS_RS02415	COG1349	DNA-binding transcription factor activity
LGAS_RS02420	COG0698	ribose 5-phosphate isomerase
LGAS_RS02425	COG0698	ribose 5-phosphate isomerase
LGAS_RS02455	COG3711	transcriptional antiterminator
LGAS_RS02460	COG1447	Phosphotransferase system cellobiose-specific component IIA
LGAS_RS02465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS02465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS02480	COG0583	DNA-binding transcription factor activity
LGAS_RS02485	COG3976	FMN-binding domain protein
LGAS_RS02485	COG1053	succinate dehydrogenase
LGAS_RS02490	COG0471	metal ion transport
LGAS_RS02540	COG3715	PTS system
LGAS_RS02555	COG0366	Alpha amylase catalytic
LGAS_RS02560	COG1609	Transcriptional regulator
LGAS_RS02570	COG3104	oligopeptide transport
LGAS_RS02590	COG1132	(ABC) transporter
LGAS_RS02595	COG1132	(ABC) transporter
LGAS_RS02600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGAS_RS02610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LGAS_RS02615	COG0765	amino acid transport
LGAS_RS02620	COG0765	amino acid transport
LGAS_RS02630	COG0366	Alpha amylase catalytic
LGAS_RS02635	COG2188	Transcriptional regulator
LGAS_RS02640	COG2190	(PTS) system
LGAS_RS02640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS02640	COG1263	PTS System
LGAS_RS02650	COG0572	uridine kinase
LGAS_RS02670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGAS_RS02680	COG0765	amino acid transport
LGAS_RS02685	COG1126	abc transporter atp-binding protein
LGAS_RS02700	COG0573	inorganic phosphate transmembrane transporter activity
LGAS_RS02705	COG0581	inorganic phosphate transmembrane transporter activity
LGAS_RS02710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LGAS_RS02715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LGAS_RS02720	COG0704	Plays a role in the regulation of phosphate uptake
LGAS_RS02725	COG1288	antiporter activity
LGAS_RS02730	COG0783	Belongs to the Dps family
LGAS_RS02755	COG2188	Transcriptional regulator
LGAS_RS02785	COG1253	flavin adenine dinucleotide binding
LGAS_RS02790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LGAS_RS02795	COG0531	amino acid
LGAS_RS02810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS02820	COG0582	viral genome integration into host DNA
LGAS_RS02835	COG1396	sequence-specific DNA binding
LGAS_RS02955	COG1475	DNA binding
LGAS_RS02975	COG5484	DNA packaging
LGAS_RS02975	COG3728	DNA packaging
LGAS_RS03080	COG3299	homolog of phage Mu protein gp47
LGAS_RS03125	COG0582	viral genome integration into host DNA
LGAS_RS03140	COG1396	sequence-specific DNA binding
LGAS_RS03260	COG1475	DNA binding
LGAS_RS03280	COG5484	DNA packaging
LGAS_RS03280	COG3728	DNA packaging
LGAS_RS03385	COG3299	homolog of phage Mu protein gp47
LGAS_RS03435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LGAS_RS03445	COG0716	FMN binding
LGAS_RS03450	COG0024	Methionine aminopeptidase
LGAS_RS03460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LGAS_RS03470	COG1125	glycine betaine transport
LGAS_RS03470	COG0517	IMP dehydrogenase activity
LGAS_RS03490	COG2357	RelA SpoT domain protein
LGAS_RS03495	COG0745	RESPONSE REGULATOR receiver
LGAS_RS03500	COG5002	protein histidine kinase activity
LGAS_RS03505	COG2936	dipeptidyl-peptidase activity
LGAS_RS03520	COG0308	aminopeptidase N
LGAS_RS03525	COG0561	phosphatase activity
LGAS_RS03540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LGAS_RS03560	COG0778	Nitroreductase
LGAS_RS03570	COG2814	Major facilitator Superfamily
LGAS_RS03575	COG0789	Transcriptional regulator
LGAS_RS03590	COG3579	cysteine-type endopeptidase activity
LGAS_RS03630	COG0351	phosphomethylpyrimidine kinase
LGAS_RS03640	COG1942	4-Oxalocrotonate Tautomerase
LGAS_RS03660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LGAS_RS03665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LGAS_RS03670	COG0006	proline dipeptidase activity
LGAS_RS03675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LGAS_RS03685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LGAS_RS03710	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LGAS_RS03715	COG0497	DNA recombination
LGAS_RS03725	COG0194	GDP metabolic process
LGAS_RS03735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LGAS_RS03745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LGAS_RS03745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LGAS_RS03750	COG0631	protein serine/threonine phosphatase activity
LGAS_RS03755	COG2815	serine threonine protein kinase
LGAS_RS03755	COG0515	serine threonine protein kinase
LGAS_RS03765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LGAS_RS03770	COG1564	THIamine pyrophosphokinase
LGAS_RS03785	COG1461	Dihydroxyacetone kinase
LGAS_RS03790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LGAS_RS03800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LGAS_RS03810	COG4608	Belongs to the ABC transporter superfamily
LGAS_RS03815	COG0601	transmembrane transport
LGAS_RS03820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LGAS_RS03835	COG0571	ribonuclease III activity
LGAS_RS03840	COG1196	nuclear chromosome segregation
LGAS_RS03845	COG0552	protein localization to endoplasmic reticulum
LGAS_RS03855	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LGAS_RS03860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LGAS_RS03865	COG0228	four-way junction DNA binding
LGAS_RS03875	COG0336	Belongs to the RNA methyltransferase TrmD family
LGAS_RS03890	COG0494	nUDIX hydrolase
LGAS_RS03905	COG4224	UPF0291 protein
LGAS_RS03915	COG1132	(ABC) transporter
LGAS_RS03920	COG1132	(ABC) transporter
LGAS_RS03930	COG0204	Acyl-transferase
LGAS_RS03935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LGAS_RS03960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LGAS_RS03965	COG4589	Belongs to the CDS family
LGAS_RS03970	COG0750	zinc metalloprotease
LGAS_RS03990	COG0195	Participates in both transcription termination and antitermination
LGAS_RS03995	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LGAS_RS04020	COG0196	riboflavin kinase activity
LGAS_RS04025	COG0488	(ABC) transporter
LGAS_RS04060	COG3764	Sortase (surface protein transpeptidase)
LGAS_RS04065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LGAS_RS04065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LGAS_RS04080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LGAS_RS04105	COG0583	DNA-binding transcription factor activity
LGAS_RS04130	COG0488	(ABC) transporter
LGAS_RS04160	COG2011	ABC-type metal ion transport system permease component
LGAS_RS04165	COG0114	fumarate hydratase activity
LGAS_RS04170	COG1053	succinate dehydrogenase
LGAS_RS04175	COG0039	L-malate dehydrogenase activity
LGAS_RS04185	COG0252	asparaginase activity
LGAS_RS04190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGAS_RS04200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LGAS_RS04215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LGAS_RS04230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LGAS_RS04240	COG1051	belongs to the nudix hydrolase family
LGAS_RS04275	COG0586	Pfam SNARE associated Golgi protein
LGAS_RS04280	COG1957	nucleoside hydrolase
LGAS_RS04295	COG2755	lipolytic protein G-D-S-L family
LGAS_RS04295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LGAS_RS04305	COG0300	oxidoreductase activity
LGAS_RS04320	COG0737	Belongs to the 5'-nucleotidase family
LGAS_RS04330	COG0587	DNA-directed DNA polymerase activity
LGAS_RS04350	COG2996	Protein conserved in bacteria
LGAS_RS04360	COG0456	acetyltransferase
LGAS_RS04375	COG1187	pseudouridine synthase activity
LGAS_RS04385	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LGAS_RS04395	COG0539	negative regulation of cytoplasmic translation
LGAS_RS04415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LGAS_RS04425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LGAS_RS04445	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LGAS_RS04455	COG1053	succinate dehydrogenase
LGAS_RS04470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LGAS_RS04480	COG1272	protein, Hemolysin III
LGAS_RS04485	COG1307	EDD domain protein, DegV family
LGAS_RS04495	COG3409	Peptidoglycan-binding domain 1 protein
LGAS_RS04495	COG0793	Belongs to the peptidase S41A family
LGAS_RS04500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LGAS_RS04510	COG0758	DNA mediated transformation
LGAS_RS04515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LGAS_RS04560	COG2855	membrane
LGAS_RS04590	COG4619	ABC transporter
LGAS_RS04595	COG0390	transport system, permease component
LGAS_RS04645	COG1011	Hydrolase
LGAS_RS04650	COG1051	belongs to the nudix hydrolase family
LGAS_RS04660	COG1114	Component of the transport system for branched-chain amino acids
LGAS_RS04695	COG1132	(ABC) transporter
LGAS_RS04700	COG1132	(ABC) transporter
LGAS_RS04710	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LGAS_RS04715	COG3250	beta-galactosidase activity
LGAS_RS04725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGAS_RS04735	COG0656	L-ascorbic acid biosynthetic process
LGAS_RS04750	COG2910	NAD(P)H-binding
LGAS_RS04755	COG2814	Major facilitator Superfamily
LGAS_RS04770	COG0446	pyridine nucleotide-disulphide oxidoreductase
LGAS_RS04815	COG2217	Heavy metal translocating P-type atpase
LGAS_RS04825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LGAS_RS04835	COG2084	Dehydrogenase
LGAS_RS04840	COG2084	Dehydrogenase
LGAS_RS04865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LGAS_RS04890	COG0667	Aldo Keto reductase
LGAS_RS04905	COG0110	maltose O-acetyltransferase activity
LGAS_RS04910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LGAS_RS04915	COG0187	DNA topoisomerase II activity
LGAS_RS04920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LGAS_RS04925	COG0583	DNA-binding transcription factor activity
LGAS_RS04935	COG0514	ATP-dependent DNA helicase (RecQ)
LGAS_RS04950	COG4974	Belongs to the 'phage' integrase family
LGAS_RS04955	COG0583	DNA-binding transcription factor activity
LGAS_RS04965	COG1307	EDD domain protein, DegV family
LGAS_RS04975	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LGAS_RS04990	COG0564	pseudouridine synthase activity
LGAS_RS05020	COG0116	Belongs to the methyltransferase superfamily
LGAS_RS05025	COG3599	regulation of cell shape
LGAS_RS05035	COG3331	DNA recombination
LGAS_RS05045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LGAS_RS05050	COG3935	DnaD domain protein
LGAS_RS05100	COG1132	(ABC) transporter
LGAS_RS05110	COG2746	aminoglycoside 3-N-acetyltransferase activity
LGAS_RS05115	COG4975	Glucose uptake
LGAS_RS05145	COG3077	Addiction module antitoxin, RelB DinJ family
LGAS_RS05150	COG3041	Addiction module toxin RelE StbE family
LGAS_RS05160	COG2365	Tyrosine phosphatase family
LGAS_RS05250	COG0737	Belongs to the 5'-nucleotidase family
LGAS_RS05270	COG0778	Nitroreductase
LGAS_RS05275	COG1053	succinate dehydrogenase
LGAS_RS05280	COG0583	DNA-binding transcription factor activity
LGAS_RS05290	COG0460	homoserine dehydrogenase
LGAS_RS05300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LGAS_RS05305	COG0527	aspartate kinase activity
LGAS_RS05310	COG3590	peptidase
LGAS_RS05320	COG1136	(ABC) transporter
LGAS_RS05330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LGAS_RS05335	COG1335	isochorismatase
LGAS_RS05345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LGAS_RS05350	COG0505	Belongs to the CarA family
LGAS_RS05370	COG0167	dihydroorotate dehydrogenase activity
LGAS_RS05380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LGAS_RS05395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LGAS_RS05440	COG1131	(ABC) transporter
LGAS_RS05445	COG1725	Transcriptional regulator
LGAS_RS05450	COG2195	Cleaves the N-terminal amino acid of tripeptides
LGAS_RS05455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LGAS_RS05460	COG2384	SAM-dependent methyltransferase
LGAS_RS05465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LGAS_RS05470	COG0358	DNA primase activity
LGAS_RS05470	COG0305	Participates in initiation and elongation during chromosome replication
LGAS_RS05490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LGAS_RS05500	COG1702	phosphate starvation-inducible protein PhoH
LGAS_RS05505	COG1610	YqeY-like protein
LGAS_RS05510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LGAS_RS05520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LGAS_RS05525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LGAS_RS05535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LGAS_RS05540	COG0436	Aminotransferase
LGAS_RS05550	COG0501	Belongs to the peptidase M48B family
LGAS_RS05565	COG1091	dTDP-4-dehydrorhamnose reductase activity
LGAS_RS05570	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LGAS_RS05585	COG2226	methyltransferase
LGAS_RS05615	COG0562	UDP-galactopyranose mutase
LGAS_RS05625	COG1442	glycosyl transferase family 8
LGAS_RS05625	COG1216	Glycosyl transferase, family 2
LGAS_RS05635	COG0438	transferase activity, transferring glycosyl groups
LGAS_RS05660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LGAS_RS05665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LGAS_RS05675	COG0489	protein tyrosine kinase activity
LGAS_RS05680	COG3944	biosynthesis protein
LGAS_RS05720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LGAS_RS05760	COG0268	Binds directly to 16S ribosomal RNA
LGAS_RS05765	COG1466	dna polymerase III delta subunit
LGAS_RS05775	COG1555	photosystem II stabilization
LGAS_RS05775	COG1596	polysaccharide export
LGAS_RS05780	COG3480	Lon protease (S16) C-terminal proteolytic domain
LGAS_RS05790	COG0742	ribosomal rna small subunit methyltransferase
LGAS_RS05795	COG4471	UPF0298 protein
LGAS_RS05800	COG0772	Belongs to the SEDS family
LGAS_RS05805	COG1217	gtp-binding protein TYPA
LGAS_RS05825	COG1597	lipid kinase activity
LGAS_RS05830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LGAS_RS05855	COG1104	cysteine desulfurase activity
LGAS_RS05870	COG0494	nUDIX hydrolase
LGAS_RS05875	COG1278	Cold shock
LGAS_RS05880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LGAS_RS05885	COG3599	regulation of cell shape
LGAS_RS05905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LGAS_RS05915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LGAS_RS05935	COG0768	penicillin binding
LGAS_RS05970	COG1077	Cell shape determining protein MreB Mrl
LGAS_RS05975	COG2003	Belongs to the UPF0758 family
LGAS_RS05980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LGAS_RS05990	COG0525	valine-tRNA ligase activity
LGAS_RS05995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LGAS_RS06005	COG1187	pseudouridine synthase activity
LGAS_RS06015	COG1104	cysteine desulfurase activity
LGAS_RS06020	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LGAS_RS06035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LGAS_RS06050	COG0772	Belongs to the SEDS family
LGAS_RS06070	COG1077	Cell shape determining protein MreB Mrl
LGAS_RS06110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LGAS_RS06115	COG0356	it plays a direct role in the translocation of protons across the membrane
LGAS_RS06125	COG0009	L-threonylcarbamoyladenylate synthase
LGAS_RS06130	COG2890	protein-(glutamine-N5) methyltransferase activity
LGAS_RS06140	COG1435	thymidine kinase activity
LGAS_RS06145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LGAS_RS06150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGAS_RS06185	COG1368	sulfuric ester hydrolase activity
LGAS_RS06190	COG5002	protein histidine kinase activity
LGAS_RS06190	COG3850	Histidine kinase
LGAS_RS06195	COG0745	RESPONSE REGULATOR receiver
LGAS_RS06205	COG1482	cell wall glycoprotein biosynthetic process
LGAS_RS06225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LGAS_RS06230	COG0827	DNA restriction-modification system
LGAS_RS06260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LGAS_RS06275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LGAS_RS06285	COG2267	carboxylic ester hydrolase activity
LGAS_RS06300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LGAS_RS06305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LGAS_RS06310	COG0561	phosphatase activity
LGAS_RS06325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LGAS_RS06335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LGAS_RS06360	COG0802	atpase or kinase
LGAS_RS06365	COG0280	phosphate acetyltransferase
LGAS_RS06370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LGAS_RS06375	COG0561	phosphatase activity
LGAS_RS06400	COG0557	exoribonuclease II activity
LGAS_RS06430	COG2390	Transcriptional regulator
LGAS_RS06435	COG0531	amino acid
LGAS_RS06465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LGAS_RS06475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LGAS_RS06480	COG2017	converts alpha-aldose to the beta-anomer
LGAS_RS06485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LGAS_RS06490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LGAS_RS06495	COG1609	Transcriptional regulator
LGAS_RS06500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LGAS_RS06505	COG0492	ferredoxin-NADP+ reductase activity
LGAS_RS06510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LGAS_RS06530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LGAS_RS06550	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LGAS_RS06555	COG1739	Uncharacterized protein family UPF0029
LGAS_RS06560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LGAS_RS06570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LGAS_RS06575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LGAS_RS06580	COG1426	Protein conserved in bacteria
LGAS_RS06585	COG0300	oxidoreductase activity
LGAS_RS06590	COG0612	Peptidase, M16
LGAS_RS06600	COG1280	lysine exporter protein (LysE YggA)
LGAS_RS06600	COG1674	ftsk spoiiie
LGAS_RS06615	COG0628	permease
LGAS_RS06625	COG2706	6-phosphogluconolactonase activity
LGAS_RS06640	COG0564	pseudouridine synthase activity
LGAS_RS06650	COG2357	RelA SpoT domain protein
LGAS_RS06655	COG4116	CYTH
LGAS_RS06675	COG1393	Belongs to the ArsC family
LGAS_RS06685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGAS_RS06695	COG0542	response to heat
LGAS_RS06710	COG1253	flavin adenine dinucleotide binding
LGAS_RS06725	COG3557	Belongs to the UPF0374 family
LGAS_RS06735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LGAS_RS06740	COG3425	synthase
LGAS_RS06750	COG0183	Belongs to the thiolase family
LGAS_RS06765	COG0561	phosphatase activity
LGAS_RS06770	COG2814	Major facilitator Superfamily
LGAS_RS06805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LGAS_RS06815	COG0768	penicillin binding
LGAS_RS06830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LGAS_RS06835	COG0072	phenylalanine-tRNA ligase activity
LGAS_RS06845	COG1733	regulation of RNA biosynthetic process
LGAS_RS06850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LGAS_RS06860	COG0706	membrane insertase activity
LGAS_RS06865	COG5002	protein histidine kinase activity
LGAS_RS06885	COG0799	negative regulation of ribosome biogenesis
LGAS_RS06890	COG1713	HD superfamily hydrolase involved in NAD metabolism
LGAS_RS06895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LGAS_RS06900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LGAS_RS06905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LGAS_RS06910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LGAS_RS06915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LGAS_RS06925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LGAS_RS06935	COG1126	abc transporter atp-binding protein
LGAS_RS06960	COG1484	DNA-dependent DNA replication
LGAS_RS06975	COG0237	dephospho-CoA kinase activity
LGAS_RS06985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LGAS_RS06985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LGAS_RS06995	COG0477	Major facilitator Superfamily
LGAS_RS07015	COG3142	Participates in the control of copper homeostasis
LGAS_RS07020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS07030	COG1446	asparaginase
LGAS_RS07040	COG2188	Transcriptional regulator
LGAS_RS07045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LGAS_RS07050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LGAS_RS07075	COG1131	(ABC) transporter
LGAS_RS07080	COG0537	adenosine 5'-monophosphoramidase activity
LGAS_RS07095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LGAS_RS07100	COG3481	metal-dependent phosphohydrolase, HD sub domain
LGAS_RS07120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LGAS_RS07125	COG0564	pseudouridine synthase activity
LGAS_RS07135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LGAS_RS07145	COG1051	belongs to the nudix hydrolase family
LGAS_RS07150	COG3231	kanamycin kinase activity
LGAS_RS07290	COG4695	Portal protein
LGAS_RS07295	COG0740	serine-type endopeptidase activity
LGAS_RS07345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LGAS_RS07355	COG1131	(ABC) transporter
LGAS_RS07360	COG1757	Na H antiporter
LGAS_RS07375	COG1122	ATPase activity
LGAS_RS07405	COG2096	Adenosyltransferase
LGAS_RS07425	COG0561	phosphatase activity
LGAS_RS07435	COG1597	lipid kinase activity
LGAS_RS07450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LGAS_RS07455	COG4851	CamS sex pheromone cAM373 precursor
LGAS_RS07470	COG1705	Flagellar rod assembly protein muramidase FlgJ
LGAS_RS07475	COG4684	Psort location CytoplasmicMembrane, score
LGAS_RS07485	COG3091	SprT-like family
LGAS_RS07500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LGAS_RS07525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LGAS_RS07530	COG0463	Glycosyl transferase, family 2
LGAS_RS07530	COG1216	Glycosyl transferase, family 2
LGAS_RS07535	COG0438	transferase activity, transferring glycosyl groups
LGAS_RS07550	COG2188	Transcriptional regulator
LGAS_RS07560	COG1054	Belongs to the UPF0176 family
LGAS_RS07580	COG1737	Transcriptional regulator
LGAS_RS07580	COG0837	glucose binding
LGAS_RS07585	COG0673	inositol 2-dehydrogenase activity
LGAS_RS07635	COG0656	L-ascorbic acid biosynthetic process
LGAS_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LGAS_RS07645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LGAS_RS07650	COG1205	dead DEAH box helicase
LGAS_RS07650	COG1111	helicase
LGAS_RS07675	COG1454	alcohol dehydrogenase
LGAS_RS07675	COG1012	belongs to the aldehyde dehydrogenase family
LGAS_RS07680	COG1113	amino acid transport
LGAS_RS07800	COG1368	sulfuric ester hydrolase activity
LGAS_RS07810	COG0438	transferase activity, transferring glycosyl groups
LGAS_RS07815	COG0438	transferase activity, transferring glycosyl groups
LGAS_RS07980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LGAS_RS08000	COG1012	belongs to the aldehyde dehydrogenase family
LGAS_RS08015	COG0561	phosphatase activity
LGAS_RS08020	COG1033	growth of symbiont in host cell
LGAS_RS08020	COG2409	Drug exporters of the RND superfamily
LGAS_RS08035	COG2971	BadF BadG BcrA BcrD
LGAS_RS08050	COG1846	Transcriptional regulator
LGAS_RS08065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LGAS_RS08075	COG1175	transmembrane transport
LGAS_RS08105	COG2176	DNA-directed DNA polymerase activity
LGAS_RS08125	COG2195	Cleaves the N-terminal amino acid of tripeptides
LGAS_RS08165	COG1823	symporter activity
LGAS_RS08170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LGAS_RS08190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LGAS_RS08210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS08210	COG2190	(PTS) system
LGAS_RS08210	COG1263	PTS System
LGAS_RS08230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LGAS_RS08235	COG1072	(Pantothenic acid kinase))
LGAS_RS08245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS08255	COG0517	IMP dehydrogenase activity
LGAS_RS08255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LGAS_RS08260	COG4990	cell redox homeostasis
LGAS_RS08265	COG3973	AAA domain
LGAS_RS08285	COG1376	ErfK ybiS ycfS ynhG family protein
LGAS_RS08290	COG1686	Belongs to the peptidase S11 family
LGAS_RS08295	COG1737	Transcriptional regulator
LGAS_RS08305	COG1263	PTS System
LGAS_RS08305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS08305	COG2190	(PTS) system
LGAS_RS08310	COG0708	Exodeoxyribonuclease III
LGAS_RS08325	COG0588	phosphoglycerate mutase activity
LGAS_RS08335	COG1136	(ABC) transporter
LGAS_RS08340	COG0531	amino acid
LGAS_RS08345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LGAS_RS08360	COG0194	GDP metabolic process
LGAS_RS08380	COG1780	Probably involved in ribonucleotide reductase function
LGAS_RS08410	COG2966	Psort location CytoplasmicMembrane, score
LGAS_RS08415	COG0488	(ABC) transporter
LGAS_RS08430	COG1316	TRANSCRIPTIONal
LGAS_RS08445	COG1620	l-lactate permease
LGAS_RS08450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LGAS_RS08455	COG1121	(ABC) transporter
LGAS_RS08465	COG0640	Transcriptional regulator
LGAS_RS08470	COG0561	phosphatase activity
LGAS_RS08480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGAS_RS08480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LGAS_RS08480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LGAS_RS08485	COG1105	Belongs to the carbohydrate kinase PfkB family
LGAS_RS08490	COG1349	DNA-binding transcription factor activity
LGAS_RS08500	COG1668	transmembrane transport
LGAS_RS08505	COG4152	abc transporter atp-binding protein
LGAS_RS08510	COG1794	racemase activity, acting on amino acids and derivatives
LGAS_RS08515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LGAS_RS08520	COG5002	protein histidine kinase activity
LGAS_RS08530	COG1132	(ABC) transporter
LGAS_RS08535	COG1132	(ABC) transporter
LGAS_RS08545	COG0012	GTP binding
LGAS_RS08550	COG4481	Protein conserved in bacteria
LGAS_RS08555	COG1475	DNA binding
LGAS_RS08560	COG1192	Involved in chromosome partitioning
LGAS_RS08595	COG0431	NADPH-dependent FMN reductase
LGAS_RS08600	COG0431	NADPH-dependent FMN reductase
LGAS_RS08620	COG2723	6-phospho-beta-galactosidase activity
LGAS_RS08625	COG2190	(PTS) system
LGAS_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS08625	COG1263	PTS System
LGAS_RS08630	COG3711	transcriptional antiterminator
LGAS_RS08635	COG1136	(ABC) transporter
LGAS_RS08650	COG0588	phosphoglycerate mutase activity
LGAS_RS08655	COG0588	phosphoglycerate mutase activity
LGAS_RS08670	COG3022	response to hydroperoxide
LGAS_RS08705	COG3104	oligopeptide transport
LGAS_RS08725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LGAS_RS08735	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LGAS_RS08740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LGAS_RS08740	COG1263	PTS System
LGAS_RS08740	COG2190	(PTS) system
LGAS_RS08755	COG2365	Tyrosine phosphatase family
LGAS_RS08760	COG0351	phosphomethylpyrimidine kinase
LGAS_RS08765	COG3442	glutamine amidotransferase
LGAS_RS08770	COG0531	amino acid
LGAS_RS08780	COG2502	aspartate--ammonia ligase
LGAS_RS08795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LGAS_RS08800	COG1113	amino acid transport
LGAS_RS08805	COG1113	amino acid transport
LGAS_RS08815	COG3716	PTS system mannose fructose sorbose family IID component
LGAS_RS08820	COG3715	PTS system
LGAS_RS08890	COG0531	amino acid
LGAS_RS08895	COG0542	response to heat
LGAS_RS08905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS08915	COG2814	Major facilitator Superfamily
LGAS_RS08925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LGAS_RS08935	COG1696	Membrane protein involved in D-alanine export
LGAS_RS08940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LGAS_RS08975	COG0517	IMP dehydrogenase activity
LGAS_RS08990	COG2274	protein secretion by the type I secretion system
LGAS_RS09025	COG3775	system Galactitol-specific IIC component
LGAS_RS09030	COG3775	system Galactitol-specific IIC component
LGAS_RS09040	COG1266	CAAX protease self-immunity
LGAS_RS09050	COG1136	(ABC) transporter
LGAS_RS09050	COG0577	efflux transmembrane transporter activity
LGAS_RS09050	COG0577	efflux transmembrane transporter activity
LGAS_RS09050	COG1136	(ABC) transporter
LGAS_RS09055	COG1271	oxidase subunit
LGAS_RS09060	COG1294	oxidase, subunit
LGAS_RS09065	COG4988	ABC transporter
LGAS_RS09070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LGAS_RS09090	COG1744	ABC transporter substrate-binding protein PnrA-like
LGAS_RS09095	COG2267	carboxylic ester hydrolase activity
LGAS_RS09100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LGAS_RS09105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LGAS_RS09125	COG4948	Mandelate Racemase Muconate Lactonizing
LGAS_RS09150	COG0656	L-ascorbic acid biosynthetic process
LGAS_RS09155	COG0363	glucosamine-6-phosphate deaminase activity
LGAS_RS09160	COG1428	Deoxynucleoside kinase
LGAS_RS09165	COG1428	Deoxynucleoside kinase
LGAS_RS09170	COG1304	FMN binding
LGAS_RS09175	COG2252	PERMEase
LGAS_RS09185	COG0789	Transcriptional regulator
LGAS_RS09185	COG4978	Transcriptional regulator
LGAS_RS09190	COG2252	PERMEase
LGAS_RS09200	COG2252	PERMEase
LGAS_RS09205	COG0242	peptide deformylase activity
LGAS_RS09245	COG3590	peptidase
LGAS_RS09250	COG0531	amino acid
LGAS_RS09260	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LGAS_RS09270	COG0477	Major facilitator Superfamily
LGAS_RS09280	COG1193	negative regulation of DNA recombination
LGAS_RS09285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LGAS_RS09305	COG0038	chloride channel
LGAS_RS09310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LGAS_RS09315	COG0028	Belongs to the TPP enzyme family
LGAS_RS09330	COG0706	membrane insertase activity