locus-tag	class	description
N506_RS00025	COG1113	amino acid transport
N506_RS00055	COG1205	dead DEAH box helicase
N506_RS00055	COG1111	helicase
N506_RS00060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N506_RS00065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N506_RS00070	COG0656	L-ascorbic acid biosynthetic process
N506_RS00090	COG3711	transcriptional antiterminator
N506_RS00095	COG2190	(PTS) system
N506_RS00095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS00095	COG1263	PTS System
N506_RS00100	COG2723	6-phospho-beta-galactosidase activity
N506_RS00135	COG0673	inositol 2-dehydrogenase activity
N506_RS00140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N506_RS00145	COG0837	glucose binding
N506_RS00145	COG1737	Transcriptional regulator
N506_RS00165	COG1054	Belongs to the UPF0176 family
N506_RS00175	COG2188	Transcriptional regulator
N506_RS00190	COG0438	transferase activity, transferring glycosyl groups
N506_RS00200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N506_RS00215	COG1132	(ABC) transporter
N506_RS00225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N506_RS00240	COG3091	SprT-like family
N506_RS00250	COG4684	Psort location CytoplasmicMembrane, score
N506_RS00255	COG1705	Flagellar rod assembly protein muramidase FlgJ
N506_RS00270	COG4851	CamS sex pheromone cAM373 precursor
N506_RS00275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N506_RS00290	COG1597	lipid kinase activity
N506_RS00300	COG0561	phosphatase activity
N506_RS00320	COG2096	Adenosyltransferase
N506_RS00350	COG1122	ATPase activity
N506_RS00365	COG1757	Na H antiporter
N506_RS00370	COG1131	(ABC) transporter
N506_RS00380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N506_RS00385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N506_RS00400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N506_RS00415	COG1051	belongs to the nudix hydrolase family
N506_RS00425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N506_RS00440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N506_RS00450	COG0420	3'-5' exonuclease activity
N506_RS00460	COG3481	metal-dependent phosphohydrolase, HD sub domain
N506_RS00465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N506_RS00480	COG0537	adenosine 5'-monophosphoramidase activity
N506_RS00485	COG1131	(ABC) transporter
N506_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N506_RS00510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N506_RS00515	COG2188	Transcriptional regulator
N506_RS00525	COG1446	asparaginase
N506_RS00535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS00540	COG3142	Participates in the control of copper homeostasis
N506_RS00550	COG2188	Transcriptional regulator
N506_RS00565	COG2197	response regulator
N506_RS00585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N506_RS00585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS00620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N506_RS00620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N506_RS00630	COG0237	dephospho-CoA kinase activity
N506_RS00645	COG1484	DNA-dependent DNA replication
N506_RS00655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N506_RS00665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N506_RS00670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N506_RS00675	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N506_RS00680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N506_RS00685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N506_RS00690	COG1713	HD superfamily hydrolase involved in NAD metabolism
N506_RS00695	COG0799	negative regulation of ribosome biogenesis
N506_RS00715	COG5002	protein histidine kinase activity
N506_RS00720	COG0706	membrane insertase activity
N506_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N506_RS00735	COG1733	regulation of RNA biosynthetic process
N506_RS00745	COG0072	phenylalanine-tRNA ligase activity
N506_RS00750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N506_RS00765	COG0768	penicillin binding
N506_RS00775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N506_RS00810	COG2814	Major facilitator Superfamily
N506_RS00815	COG0561	phosphatase activity
N506_RS00830	COG0183	Belongs to the thiolase family
N506_RS00840	COG3425	synthase
N506_RS00845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N506_RS00855	COG3557	Belongs to the UPF0374 family
N506_RS00870	COG1253	flavin adenine dinucleotide binding
N506_RS00885	COG0542	response to heat
N506_RS00895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N506_RS00905	COG1393	Belongs to the ArsC family
N506_RS00925	COG4116	CYTH
N506_RS00930	COG2357	RelA SpoT domain protein
N506_RS00940	COG0564	pseudouridine synthase activity
N506_RS00955	COG2706	6-phosphogluconolactonase activity
N506_RS00965	COG0628	permease
N506_RS00980	COG1674	ftsk spoiiie
N506_RS00980	COG1280	lysine exporter protein (LysE YggA)
N506_RS00990	COG0612	Peptidase, M16
N506_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
N506_RS01000	COG1426	Protein conserved in bacteria
N506_RS01005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N506_RS01010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N506_RS01020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N506_RS01025	COG1739	Uncharacterized protein family UPF0029
N506_RS01030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N506_RS01050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N506_RS01070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N506_RS01075	COG0492	ferredoxin-NADP+ reductase activity
N506_RS01080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N506_RS01085	COG1609	Transcriptional regulator
N506_RS01090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N506_RS01095	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
N506_RS01100	COG2017	converts alpha-aldose to the beta-anomer
N506_RS01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N506_RS01115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N506_RS01145	COG0531	amino acid
N506_RS01150	COG2390	Transcriptional regulator
N506_RS01180	COG0557	exoribonuclease II activity
N506_RS01205	COG0561	phosphatase activity
N506_RS01210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N506_RS01215	COG0280	phosphate acetyltransferase
N506_RS01220	COG0802	atpase or kinase
N506_RS01245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N506_RS01255	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N506_RS01270	COG0561	phosphatase activity
N506_RS01275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N506_RS01280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N506_RS01295	COG2267	carboxylic ester hydrolase activity
N506_RS01305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N506_RS01350	COG0827	DNA restriction-modification system
N506_RS01355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N506_RS01380	COG1482	cell wall glycoprotein biosynthetic process
N506_RS01390	COG0745	RESPONSE REGULATOR receiver
N506_RS01395	COG5002	protein histidine kinase activity
N506_RS01395	COG3850	Histidine kinase
N506_RS01400	COG1368	sulfuric ester hydrolase activity
N506_RS01415	COG2814	Major facilitator Superfamily
N506_RS01435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N506_RS01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N506_RS01445	COG1435	thymidine kinase activity
N506_RS01455	COG2890	protein-(glutamine-N5) methyltransferase activity
N506_RS01460	COG0009	L-threonylcarbamoyladenylate synthase
N506_RS01470	COG0356	it plays a direct role in the translocation of protons across the membrane
N506_RS01475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N506_RS01515	COG1077	Cell shape determining protein MreB Mrl
N506_RS01535	COG0772	Belongs to the SEDS family
N506_RS01550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N506_RS01565	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N506_RS01570	COG1104	cysteine desulfurase activity
N506_RS01590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N506_RS01595	COG0525	valine-tRNA ligase activity
N506_RS01605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N506_RS01610	COG2003	Belongs to the UPF0758 family
N506_RS01615	COG1077	Cell shape determining protein MreB Mrl
N506_RS01655	COG0768	penicillin binding
N506_RS01675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N506_RS01685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N506_RS01705	COG3599	regulation of cell shape
N506_RS01710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N506_RS01715	COG1278	Cold shock
N506_RS01720	COG0494	nUDIX hydrolase
N506_RS01735	COG1104	cysteine desulfurase activity
N506_RS01760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N506_RS01765	COG1597	lipid kinase activity
N506_RS01785	COG1217	gtp-binding protein TYPA
N506_RS01790	COG0772	Belongs to the SEDS family
N506_RS01795	COG4471	UPF0298 protein
N506_RS01800	COG0742	ribosomal rna small subunit methyltransferase
N506_RS01810	COG3480	Lon protease (S16) C-terminal proteolytic domain
N506_RS01815	COG1596	polysaccharide export
N506_RS01815	COG1555	photosystem II stabilization
N506_RS01825	COG1466	dna polymerase III delta subunit
N506_RS01830	COG0268	Binds directly to 16S ribosomal RNA
N506_RS01870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N506_RS01910	COG3944	biosynthesis protein
N506_RS01915	COG0489	protein tyrosine kinase activity
N506_RS01920	COG4464	protein tyrosine phosphatase activity
N506_RS01925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N506_RS01930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N506_RS01955	COG0438	transferase activity, transferring glycosyl groups
N506_RS01965	COG1442	glycosyl transferase family 8
N506_RS01965	COG1216	Glycosyl transferase, family 2
N506_RS01975	COG0562	UDP-galactopyranose mutase
N506_RS02015	COG5290	Psort location Cytoplasmic, score
N506_RS02050	COG2226	methyltransferase
N506_RS02065	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N506_RS02070	COG1091	dTDP-4-dehydrorhamnose reductase activity
N506_RS02085	COG1518	maintenance of DNA repeat elements
N506_RS02130	COG1857	crispr-associated protein
N506_RS02145	COG1518	maintenance of DNA repeat elements
N506_RS02150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N506_RS02160	COG0436	Aminotransferase
N506_RS02165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N506_RS02175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N506_RS02180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N506_RS02190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N506_RS02195	COG1610	YqeY-like protein
N506_RS02200	COG1702	phosphate starvation-inducible protein PhoH
N506_RS02210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N506_RS02230	COG0305	Participates in initiation and elongation during chromosome replication
N506_RS02230	COG0358	DNA primase activity
N506_RS02235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N506_RS02240	COG2384	SAM-dependent methyltransferase
N506_RS02245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N506_RS02250	COG2195	Cleaves the N-terminal amino acid of tripeptides
N506_RS02255	COG1725	Transcriptional regulator
N506_RS02260	COG1131	(ABC) transporter
N506_RS02295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N506_RS02295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N506_RS02305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N506_RS02320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N506_RS02330	COG0167	dihydroorotate dehydrogenase activity
N506_RS02350	COG0505	Belongs to the CarA family
N506_RS02355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N506_RS02365	COG1335	isochorismatase
N506_RS02370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N506_RS02380	COG1136	(ABC) transporter
N506_RS02390	COG1811	Na channel or pump
N506_RS02395	COG0583	DNA-binding transcription factor activity
N506_RS02400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N506_RS02405	COG0163	prenyltransferase activity
N506_RS02420	COG3590	peptidase
N506_RS02425	COG0527	aspartate kinase activity
N506_RS02430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N506_RS02440	COG0460	homoserine dehydrogenase
N506_RS02460	COG0778	Nitroreductase
N506_RS02475	COG2211	Major facilitator Superfamily
N506_RS02475	COG2190	(PTS) system
N506_RS02480	COG3711	transcriptional antiterminator
N506_RS02485	COG2190	(PTS) system
N506_RS02485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS02485	COG1263	PTS System
N506_RS02490	COG3394	polysaccharide catabolic process
N506_RS02500	COG0737	Belongs to the 5'-nucleotidase family
N506_RS02550	COG1132	(ABC) transporter
N506_RS02590	COG3041	Addiction module toxin RelE StbE family
N506_RS02595	COG3077	Addiction module antitoxin, RelB DinJ family
N506_RS02625	COG0494	nUDIX hydrolase
N506_RS02645	COG4975	Glucose uptake
N506_RS02650	COG2746	aminoglycoside 3-N-acetyltransferase activity
N506_RS02665	COG1132	(ABC) transporter
N506_RS02715	COG3935	DnaD domain protein
N506_RS02720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N506_RS02730	COG3331	DNA recombination
N506_RS02740	COG3599	regulation of cell shape
N506_RS02750	COG0116	Belongs to the methyltransferase superfamily
N506_RS02780	COG0564	pseudouridine synthase activity
N506_RS02795	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N506_RS02805	COG1307	EDD domain protein, DegV family
N506_RS02815	COG0583	DNA-binding transcription factor activity
N506_RS02820	COG4974	Belongs to the 'phage' integrase family
N506_RS02845	COG0583	DNA-binding transcription factor activity
N506_RS02850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N506_RS02855	COG0187	DNA topoisomerase II activity
N506_RS02860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N506_RS02865	COG0110	maltose O-acetyltransferase activity
N506_RS02880	COG0667	Aldo Keto reductase
N506_RS02895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N506_RS02935	COG4977	sequence-specific DNA binding
N506_RS02935	COG1917	Cupin 2, conserved barrel domain protein
N506_RS02940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N506_RS02950	COG2814	Major facilitator Superfamily
N506_RS02955	COG0446	pyridine nucleotide-disulphide oxidoreductase
N506_RS02990	COG2910	NAD(P)H-binding
N506_RS03010	COG0656	L-ascorbic acid biosynthetic process
N506_RS03015	COG1132	(ABC) transporter
N506_RS03020	COG1132	(ABC) transporter
N506_RS03025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N506_RS03035	COG3250	beta-galactosidase activity
N506_RS03040	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
N506_RS03050	COG1132	(ABC) transporter
N506_RS03055	COG1132	(ABC) transporter
N506_RS03085	COG1914	H( )-stimulated, divalent metal cation uptake system
N506_RS03095	COG0719	Fe-S assembly protein
N506_RS03100	COG0822	iron-sulfur transferase activity
N506_RS03105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N506_RS03110	COG0719	Fe-S assembly protein
N506_RS03120	COG1114	Component of the transport system for branched-chain amino acids
N506_RS03130	COG1051	belongs to the nudix hydrolase family
N506_RS03135	COG1011	Hydrolase
N506_RS03150	COG0656	L-ascorbic acid biosynthetic process
N506_RS03175	COG3527	Alpha-acetolactate decarboxylase
N506_RS03180	COG0028	Belongs to the TPP enzyme family
N506_RS03190	COG0390	transport system, permease component
N506_RS03195	COG4619	ABC transporter
N506_RS03245	COG0488	(ABC) transporter
N506_RS03260	COG1063	alcohol dehydrogenase
N506_RS03270	COG0583	DNA-binding transcription factor activity
N506_RS03285	COG2855	membrane
N506_RS03330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N506_RS03335	COG0758	DNA mediated transformation
N506_RS03345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N506_RS03350	COG0793	Belongs to the peptidase S41A family
N506_RS03350	COG3409	Peptidoglycan-binding domain 1 protein
N506_RS03360	COG1307	EDD domain protein, DegV family
N506_RS03365	COG1272	protein, Hemolysin III
N506_RS03375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N506_RS03380	COG1373	ATPase (AAA superfamily
N506_RS03385	COG1053	succinate dehydrogenase
N506_RS03420	COG1160	GTP binding
N506_RS03425	COG0539	negative regulation of cytoplasmic translation
N506_RS03435	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N506_RS03445	COG1187	pseudouridine synthase activity
N506_RS03460	COG0456	acetyltransferase
N506_RS03470	COG2996	Protein conserved in bacteria
N506_RS03490	COG0587	DNA-directed DNA polymerase activity
N506_RS03500	COG0737	Belongs to the 5'-nucleotidase family
N506_RS03505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N506_RS03515	COG0300	oxidoreductase activity
N506_RS03525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N506_RS03525	COG2755	lipolytic protein G-D-S-L family
N506_RS03540	COG1957	nucleoside hydrolase
N506_RS03545	COG0586	Pfam SNARE associated Golgi protein
N506_RS03555	COG0531	amino acid
N506_RS03580	COG1051	belongs to the nudix hydrolase family
N506_RS03590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N506_RS03605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N506_RS03620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N506_RS03635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N506_RS03640	COG0252	asparaginase activity
N506_RS03650	COG0039	L-malate dehydrogenase activity
N506_RS03655	COG1053	succinate dehydrogenase
N506_RS03660	COG0114	fumarate hydratase activity
N506_RS03665	COG2011	ABC-type metal ion transport system permease component
N506_RS03695	COG0488	(ABC) transporter
N506_RS03705	COG0148	phosphopyruvate hydratase activity
N506_RS03720	COG0583	DNA-binding transcription factor activity
N506_RS03725	COG2217	Heavy metal translocating P-type atpase
N506_RS03745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N506_RS03760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N506_RS03760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N506_RS03765	COG3764	Sortase (surface protein transpeptidase)
N506_RS03800	COG0488	(ABC) transporter
N506_RS03805	COG0196	riboflavin kinase activity
N506_RS03820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N506_RS03830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N506_RS03835	COG0195	Participates in both transcription termination and antitermination
N506_RS03855	COG0750	zinc metalloprotease
N506_RS03860	COG4589	Belongs to the CDS family
N506_RS03865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N506_RS03890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N506_RS03895	COG0204	Acyl-transferase
N506_RS03905	COG1132	(ABC) transporter
N506_RS03910	COG1132	(ABC) transporter
N506_RS03915	COG3763	UPF0154 protein
N506_RS03920	COG4224	UPF0291 protein
N506_RS03935	COG0494	nUDIX hydrolase
N506_RS03950	COG0336	Belongs to the RNA methyltransferase TrmD family
N506_RS03960	COG0228	four-way junction DNA binding
N506_RS03965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N506_RS03970	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
N506_RS03980	COG0552	protein localization to endoplasmic reticulum
N506_RS03985	COG1196	nuclear chromosome segregation
N506_RS03990	COG0571	ribonuclease III activity
N506_RS04005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N506_RS04010	COG0601	transmembrane transport
N506_RS04015	COG4608	Belongs to the ABC transporter superfamily
N506_RS04025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N506_RS04035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N506_RS04040	COG1461	Dihydroxyacetone kinase
N506_RS04055	COG1564	THIamine pyrophosphokinase
N506_RS04060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N506_RS04070	COG0515	serine threonine protein kinase
N506_RS04070	COG2815	serine threonine protein kinase
N506_RS04075	COG0631	protein serine/threonine phosphatase activity
N506_RS04080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N506_RS04080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N506_RS04090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N506_RS04100	COG0194	GDP metabolic process
N506_RS04110	COG0497	DNA recombination
N506_RS04115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N506_RS04140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N506_RS04150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N506_RS04155	COG0006	proline dipeptidase activity
N506_RS04160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N506_RS04165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N506_RS04170	COG1393	Belongs to the ArsC family
N506_RS04190	COG1942	4-Oxalocrotonate Tautomerase
N506_RS04240	COG3579	cysteine-type endopeptidase activity
N506_RS04255	COG0789	Transcriptional regulator
N506_RS04270	COG0778	Nitroreductase
N506_RS04290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N506_RS04305	COG0561	phosphatase activity
N506_RS04310	COG0308	aminopeptidase N
N506_RS04320	COG2936	dipeptidyl-peptidase activity
N506_RS04325	COG5002	protein histidine kinase activity
N506_RS04330	COG0745	RESPONSE REGULATOR receiver
N506_RS04335	COG2357	RelA SpoT domain protein
N506_RS04355	COG1125	glycine betaine transport
N506_RS04355	COG0517	IMP dehydrogenase activity
N506_RS04365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N506_RS04375	COG0024	Methionine aminopeptidase
N506_RS04380	COG0716	FMN binding
N506_RS04390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N506_RS04405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS04420	COG0531	amino acid
N506_RS04425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N506_RS04430	COG1253	flavin adenine dinucleotide binding
N506_RS04460	COG2188	Transcriptional regulator
N506_RS04485	COG0783	Belongs to the Dps family
N506_RS04490	COG1288	antiporter activity
N506_RS04495	COG0704	Plays a role in the regulation of phosphate uptake
N506_RS04500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N506_RS04505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N506_RS04510	COG0581	inorganic phosphate transmembrane transporter activity
N506_RS04515	COG0573	inorganic phosphate transmembrane transporter activity
N506_RS04530	COG1126	abc transporter atp-binding protein
N506_RS04535	COG0765	amino acid transport
N506_RS04545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N506_RS04595	COG2274	protein secretion by the type I secretion system
N506_RS04620	COG0572	uridine kinase
N506_RS04645	COG2188	Transcriptional regulator
N506_RS04650	COG0366	Alpha amylase catalytic
N506_RS04660	COG0765	amino acid transport
N506_RS04665	COG0765	amino acid transport
N506_RS04670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N506_RS04680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N506_RS04690	COG1132	(ABC) transporter
N506_RS04705	COG2814	Major facilitator Superfamily
N506_RS04710	COG3104	oligopeptide transport
N506_RS04720	COG1609	Transcriptional regulator
N506_RS04725	COG0366	Alpha amylase catalytic
N506_RS04740	COG3715	PTS system
N506_RS04790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N506_RS04795	COG1461	Dihydroxyacetone kinase
N506_RS04800	COG2376	Dihydroxyacetone kinase
N506_RS04810	COG0471	metal ion transport
N506_RS04815	COG3976	FMN-binding domain protein
N506_RS04815	COG1053	succinate dehydrogenase
N506_RS04820	COG0583	DNA-binding transcription factor activity
N506_RS04835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS04835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS04840	COG1447	Phosphotransferase system cellobiose-specific component IIA
N506_RS04845	COG3711	transcriptional antiterminator
N506_RS04875	COG0698	ribose 5-phosphate isomerase
N506_RS04880	COG0698	ribose 5-phosphate isomerase
N506_RS04885	COG1349	DNA-binding transcription factor activity
N506_RS04905	COG0561	phosphatase activity
N506_RS04915	COG0561	phosphatase activity
N506_RS04920	COG0456	acetyltransferase
N506_RS04925	COG4716	Myosin-crossreactive antigen
N506_RS04935	COG2814	Major facilitator Superfamily
N506_RS04940	COG2814	Major facilitator Superfamily
N506_RS04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N506_RS04970	COG2723	6-phospho-beta-galactosidase activity
N506_RS04975	COG1263	PTS System
N506_RS04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS04975	COG2190	(PTS) system
N506_RS04985	COG1956	GAF domain-containing protein
N506_RS05025	COG0018	arginyl-trna synthetase
N506_RS05030	COG1686	Belongs to the peptidase S11 family
N506_RS05035	COG1376	ErfK ybiS ycfS ynhG family protein
N506_RS05040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N506_RS05055	COG2244	polysaccharide biosynthetic process
N506_RS05075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N506_RS05115	COG1098	S1 RNA binding domain
N506_RS05125	COG0586	Pfam SNARE associated Golgi protein
N506_RS05135	COG0647	UMP catabolic process
N506_RS05145	COG0737	Belongs to the 5'-nucleotidase family
N506_RS05155	COG0584	glycerophosphoryl diester phosphodiesterase
N506_RS05175	COG0006	proline dipeptidase activity
N506_RS05190	COG0668	transmembrane transport
N506_RS05195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N506_RS05200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N506_RS05205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N506_RS05210	COG1719	4-vinyl reductase, 4VR
N506_RS05215	COG3118	belongs to the thioredoxin family
N506_RS05250	COG0513	Belongs to the DEAD box helicase family
N506_RS05255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N506_RS05260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N506_RS05265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N506_RS05270	COG1862	Preprotein translocase
N506_RS05345	COG0488	(ABC) transporter
N506_RS05375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N506_RS05405	COG1214	PFAM Peptidase M22, glycoprotease
N506_RS05410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N506_RS05435	COG3870	Protein conserved in bacteria
N506_RS05440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N506_RS05460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N506_RS05470	COG0590	tRNA wobble adenosine to inosine editing
N506_RS05480	COG2813	Specifically methylates the guanine in position
N506_RS05500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N506_RS05505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N506_RS05510	COG1126	abc transporter atp-binding protein
N506_RS05515	COG0765	amino acid transport
N506_RS05525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N506_RS05530	COG0250	Participates in transcription elongation, termination and antitermination
N506_RS05555	COG0142	geranyltranstransferase activity
N506_RS05570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N506_RS05575	COG1929	Belongs to the glycerate kinase type-1 family
N506_RS05580	COG1070	Carbohydrate kinase
N506_RS05595	COG2723	6-phospho-beta-galactosidase activity
N506_RS05600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS05600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS05605	COG1447	Phosphotransferase system cellobiose-specific component IIA
N506_RS05610	COG3711	transcriptional antiterminator
N506_RS05615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N506_RS05620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
N506_RS05640	COG0756	dUTP diphosphatase activity
N506_RS05655	COG0588	phosphoglycerate mutase activity
N506_RS05675	COG0640	Transcriptional regulator
N506_RS05705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N506_RS05710	COG0101	tRNA pseudouridine synthase activity
N506_RS05715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N506_RS05730	COG0203	ribosomal protein L17
N506_RS05755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N506_RS05770	COG0200	Binds to the 23S rRNA
N506_RS05825	COG0255	Belongs to the universal ribosomal protein uL29 family
N506_RS05905	COG0542	response to heat
N506_RS05920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N506_RS05925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N506_RS05930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N506_RS05960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N506_RS05965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N506_RS05975	COG0039	L-malate dehydrogenase activity
N506_RS05990	COG0736	holo-[acyl-carrier-protein] synthase activity
N506_RS06000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N506_RS06010	COG0531	amino acid
N506_RS06020	COG4120	Belongs to the binding-protein-dependent transport system permease family
N506_RS06040	COG4690	dipeptidase activity
N506_RS06045	COG3345	alpha-galactosidase
N506_RS06070	COG0148	phosphopyruvate hydratase activity
N506_RS06080	COG0679	Auxin Efflux Carrier
N506_RS06085	COG0028	Belongs to the TPP enzyme family
N506_RS06090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N506_RS06105	COG1575	Belongs to the MenA family. Type 1 subfamily
N506_RS06140	COG1396	sequence-specific DNA binding
N506_RS06165	COG2233	PERMEase
N506_RS06170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N506_RS06175	COG0504	CTP synthase activity
N506_RS06180	COG3343	RNA polymerase activity
N506_RS06190	COG1078	dGTPase activity
N506_RS06195	COG0366	Alpha amylase catalytic
N506_RS06200	COG3833	ABC-type maltose transport systems, permease component
N506_RS06205	COG1175	transmembrane transport
N506_RS06210	COG1653	transport
N506_RS06215	COG3842	ATPase activity
N506_RS06220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N506_RS06235	COG0366	Alpha amylase catalytic
N506_RS06240	COG1609	Transcriptional regulator
N506_RS06245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N506_RS06255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N506_RS06260	COG4466	Protein conserved in bacteria
N506_RS06265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N506_RS06275	COG0084	hydrolase, TatD family'
N506_RS06280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N506_RS06280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N506_RS06285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N506_RS06295	COG2131	deaminase
N506_RS06305	COG2135	peptidase activity
N506_RS06320	COG1940	carbohydrate kinase activity
N506_RS06325	COG2723	6-phospho-beta-galactosidase activity
N506_RS06330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS06335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS06345	COG1447	Phosphotransferase system cellobiose-specific component IIA
N506_RS06350	COG2188	Transcriptional regulator
N506_RS06355	COG2723	6-phospho-beta-galactosidase activity
N506_RS06365	COG2188	Transcriptional regulator
N506_RS06370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS06380	COG2723	6-phospho-beta-galactosidase activity
N506_RS06390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N506_RS06410	COG1418	mRNA catabolic process
N506_RS06415	COG3579	cysteine-type endopeptidase activity
N506_RS06425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N506_RS06430	COG1368	sulfuric ester hydrolase activity
N506_RS06435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N506_RS06440	COG1316	TRANSCRIPTIONal
N506_RS06450	COG4975	Glucose uptake
N506_RS06470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N506_RS06480	COG0588	phosphoglycerate mutase activity
N506_RS06500	COG0673	inositol 2-dehydrogenase activity
N506_RS06505	COG0475	glutathione-regulated potassium exporter activity
N506_RS06505	COG0569	domain protein
N506_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N506_RS06520	COG1705	Flagellar rod assembly protein muramidase FlgJ
N506_RS06520	COG1388	LysM domain
N506_RS06550	COG3158	transport of potassium into the cell
N506_RS06555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N506_RS06565	COG3590	peptidase
N506_RS06570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N506_RS06570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N506_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N506_RS06590	COG3684	Belongs to the aldolase LacD family
N506_RS06595	COG2814	Major facilitator Superfamily
N506_RS06610	COG2151	metal-sulfur cluster biosynthetic enzyme
N506_RS06615	COG0602	queuosine metabolic process
N506_RS06620	COG1328	CTP reductase activity
N506_RS06635	COG0367	asparagine synthase
N506_RS06650	COG3639	organic phosphonate transmembrane transporter activity
N506_RS06670	COG0589	response to stress
N506_RS06675	COG2365	Tyrosine phosphatase family
N506_RS06680	COG2188	Transcriptional regulator
N506_RS06690	COG3613	nucleoside 2-deoxyribosyltransferase
N506_RS06710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N506_RS06710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS06715	COG3716	PTS system mannose fructose sorbose family IID component
N506_RS06725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS06735	COG2222	sugar isomerase
N506_RS06740	COG2188	Transcriptional regulator
N506_RS06765	COG0025	NhaP-type Na H and K H
N506_RS06795	COG1113	amino acid transport
N506_RS06805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N506_RS06815	COG2267	carboxylic ester hydrolase activity
N506_RS06820	COG1216	Glycosyl transferase, family 2
N506_RS06830	COG0328	RNA-DNA hybrid ribonuclease activity
N506_RS06840	COG2738	Putative neutral zinc metallopeptidase
N506_RS06845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N506_RS06855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N506_RS06860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N506_RS06865	COG0861	Integral membrane protein TerC family
N506_RS06870	COG3189	MarR family transcriptional regulator
N506_RS06875	COG2094	Belongs to the DNA glycosylase MPG family
N506_RS06880	COG0765	amino acid transport
N506_RS06885	COG1126	abc transporter atp-binding protein
N506_RS06900	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N506_RS06905	COG1215	transferase activity, transferring glycosyl groups
N506_RS06925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N506_RS06930	COG1704	LemA family
N506_RS06935	COG0501	Belongs to the peptidase M48B family
N506_RS06950	COG1122	ATPase activity
N506_RS06965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N506_RS06970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N506_RS06985	COG5002	protein histidine kinase activity
N506_RS06990	COG0745	RESPONSE REGULATOR receiver
N506_RS07050	COG2267	carboxylic ester hydrolase activity
N506_RS07055	COG2226	methyltransferase
N506_RS07060	COG1114	Component of the transport system for branched-chain amino acids
N506_RS07065	COG1053	succinate dehydrogenase
N506_RS07065	COG3976	FMN-binding domain protein
N506_RS07075	COG0531	amino acid
N506_RS07095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N506_RS07105	COG0516	GMP reductase activity
N506_RS07105	COG0517	IMP dehydrogenase activity
N506_RS07115	COG0628	permease
N506_RS07135	COG0708	Exodeoxyribonuclease III
N506_RS07140	COG2261	transglycosylase associated protein
N506_RS07165	COG1307	EDD domain protein, DegV family
N506_RS07170	COG1011	Hydrolase
N506_RS07205	COG1396	sequence-specific DNA binding
N506_RS07205	COG3800	Transcriptional regulator
N506_RS07220	COG1285	pathogenesis
N506_RS07235	COG1940	carbohydrate kinase activity
N506_RS07240	COG0305	Participates in initiation and elongation during chromosome replication
N506_RS07245	COG0359	binds to the 23S rRNA
N506_RS07260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N506_RS07265	COG0629	single-stranded DNA binding
N506_RS07275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N506_RS07280	COG0187	DNA topoisomerase II activity
N506_RS07290	COG2501	S4 domain
N506_RS07295	COG0592	DNA-directed DNA polymerase activity
N506_RS07300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N506_RS07315	COG0706	membrane insertase activity
N506_RS07330	COG0028	Belongs to the TPP enzyme family
N506_RS07335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N506_RS07340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS07365	COG0038	chloride channel
N506_RS07370	COG1335	isochorismatase
N506_RS07375	COG0477	Major facilitator Superfamily
N506_RS07380	COG2801	Transposase and inactivated derivatives
N506_RS07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N506_RS07405	COG1193	negative regulation of DNA recombination
N506_RS07415	COG0477	Major facilitator Superfamily
N506_RS07420	COG3153	acetyltransferase
N506_RS07425	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
N506_RS07435	COG0531	amino acid
N506_RS07445	COG3590	peptidase
N506_RS07485	COG0366	Alpha amylase catalytic
N506_RS07490	COG1263	PTS System
N506_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS07490	COG2190	(PTS) system
N506_RS07495	COG0242	peptide deformylase activity
N506_RS07505	COG2252	PERMEase
N506_RS07515	COG2252	PERMEase
N506_RS07520	COG0789	Transcriptional regulator
N506_RS07520	COG4978	Transcriptional regulator
N506_RS07535	COG2252	PERMEase
N506_RS07540	COG1304	FMN binding
N506_RS07545	COG1428	Deoxynucleoside kinase
N506_RS07550	COG1428	Deoxynucleoside kinase
N506_RS07555	COG0363	glucosamine-6-phosphate deaminase activity
N506_RS07560	COG0656	L-ascorbic acid biosynthetic process
N506_RS07570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS07575	COG3715	PTS system
N506_RS07580	COG3716	PTS system mannose fructose sorbose family IID component
N506_RS07605	COG4948	Mandelate Racemase Muconate Lactonizing
N506_RS07610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N506_RS07620	COG3716	PTS system mannose fructose sorbose family IID component
N506_RS07625	COG3715	PTS system
N506_RS07635	COG2267	carboxylic ester hydrolase activity
N506_RS07640	COG1744	ABC transporter substrate-binding protein PnrA-like
N506_RS07655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N506_RS07660	COG4988	ABC transporter
N506_RS07665	COG1294	oxidase, subunit
N506_RS07670	COG1271	oxidase subunit
N506_RS07675	COG0577	efflux transmembrane transporter activity
N506_RS07675	COG1136	(ABC) transporter
N506_RS07675	COG1136	(ABC) transporter
N506_RS07675	COG0577	efflux transmembrane transporter activity
N506_RS07685	COG1266	CAAX protease self-immunity
N506_RS07695	COG3775	system Galactitol-specific IIC component
N506_RS07760	COG0517	IMP dehydrogenase activity
N506_RS07800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N506_RS07805	COG1696	Membrane protein involved in D-alanine export
N506_RS07815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
N506_RS07825	COG2814	Major facilitator Superfamily
N506_RS07835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS07845	COG0542	response to heat
N506_RS07850	COG0531	amino acid
N506_RS07880	COG3715	PTS system
N506_RS07885	COG3716	PTS system mannose fructose sorbose family IID component
N506_RS07895	COG1113	amino acid transport
N506_RS07900	COG1113	amino acid transport
N506_RS07905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N506_RS07920	COG2502	aspartate--ammonia ligase
N506_RS07930	COG0531	amino acid
N506_RS07935	COG3442	glutamine amidotransferase
N506_RS07940	COG0351	phosphomethylpyrimidine kinase
N506_RS07945	COG2365	Tyrosine phosphatase family
N506_RS07960	COG1263	PTS System
N506_RS07960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS07960	COG2190	(PTS) system
N506_RS07965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N506_RS07975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N506_RS07995	COG3104	oligopeptide transport
N506_RS08030	COG3022	response to hydroperoxide
N506_RS08045	COG0588	phosphoglycerate mutase activity
N506_RS08050	COG0588	phosphoglycerate mutase activity
N506_RS08065	COG1136	(ABC) transporter
N506_RS08070	COG3711	transcriptional antiterminator
N506_RS08075	COG1263	PTS System
N506_RS08075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS08075	COG2190	(PTS) system
N506_RS08080	COG2723	6-phospho-beta-galactosidase activity
N506_RS08100	COG0431	NADPH-dependent FMN reductase
N506_RS08105	COG0431	NADPH-dependent FMN reductase
N506_RS08140	COG1192	Involved in chromosome partitioning
N506_RS08145	COG1475	DNA binding
N506_RS08150	COG4481	Protein conserved in bacteria
N506_RS08155	COG0012	GTP binding
N506_RS08165	COG1132	(ABC) transporter
N506_RS08170	COG1132	(ABC) transporter
N506_RS08180	COG5002	protein histidine kinase activity
N506_RS08185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N506_RS08190	COG1794	racemase activity, acting on amino acids and derivatives
N506_RS08195	COG4152	abc transporter atp-binding protein
N506_RS08200	COG1668	transmembrane transport
N506_RS08210	COG1349	DNA-binding transcription factor activity
N506_RS08215	COG1105	Belongs to the carbohydrate kinase PfkB family
N506_RS08220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N506_RS08220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N506_RS08220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N506_RS08230	COG0561	phosphatase activity
N506_RS08235	COG0640	Transcriptional regulator
N506_RS08245	COG1121	(ABC) transporter
N506_RS08250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N506_RS08255	COG1620	l-lactate permease
N506_RS08285	COG1164	Oligoendopeptidase f
N506_RS08290	COG1316	TRANSCRIPTIONal
N506_RS08305	COG0488	(ABC) transporter
N506_RS08310	COG2966	Psort location CytoplasmicMembrane, score
N506_RS08340	COG1780	Probably involved in ribonucleotide reductase function
N506_RS08360	COG0194	GDP metabolic process
N506_RS08375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N506_RS08380	COG0531	amino acid
N506_RS08385	COG1136	(ABC) transporter
N506_RS08395	COG0588	phosphoglycerate mutase activity
N506_RS08410	COG0708	Exodeoxyribonuclease III
N506_RS08415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS08415	COG1263	PTS System
N506_RS08415	COG2190	(PTS) system
N506_RS08425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N506_RS08430	COG1686	Belongs to the peptidase S11 family
N506_RS08455	COG3973	AAA domain
N506_RS08460	COG4990	cell redox homeostasis
N506_RS08470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N506_RS08475	COG0698	ribose 5-phosphate isomerase
N506_RS08480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS08490	COG2723	6-phospho-beta-galactosidase activity
N506_RS08495	COG0517	IMP dehydrogenase activity
N506_RS08495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N506_RS08505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N506_RS08515	COG1072	(Pantothenic acid kinase))
N506_RS08520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N506_RS08535	COG1263	PTS System
N506_RS08535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N506_RS08535	COG2190	(PTS) system
N506_RS08560	COG0747	negative chemotaxis
N506_RS08565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N506_RS08580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N506_RS08585	COG1823	symporter activity
N506_RS08620	COG2195	Cleaves the N-terminal amino acid of tripeptides
N506_RS08640	COG2176	DNA-directed DNA polymerase activity
N506_RS08670	COG1175	transmembrane transport
N506_RS08680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N506_RS08695	COG1846	Transcriptional regulator
N506_RS08710	COG2971	BadF BadG BcrA BcrD
N506_RS08725	COG1033	growth of symbiont in host cell
N506_RS08725	COG2409	Drug exporters of the RND superfamily
N506_RS08730	COG0561	phosphatase activity
N506_RS08745	COG1012	belongs to the aldehyde dehydrogenase family
N506_RS08765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N506_RS08930	COG0438	transferase activity, transferring glycosyl groups
N506_RS08935	COG0438	transferase activity, transferring glycosyl groups
N506_RS08945	COG1368	sulfuric ester hydrolase activity
N506_RS09075	COG1113	amino acid transport
N506_RS09140	COG1136	(ABC) transporter
N506_RS09210	COG1192	Involved in chromosome partitioning
N506_RS09260	COG1132	(ABC) transporter
N506_RS09285	COG1192	Involved in chromosome partitioning
N506_RS09325	COG1970	mechanosensitive ion channel activity
N506_RS09330	COG1373	ATPase (AAA superfamily
N506_RS09335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N506_RS09340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N506_RS09345	COG3328	transposase activity
N506_RS09365	COG0604	alcohol dehydrogenase
N506_RS09395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N506_RS09470	COG0640	Transcriptional regulator
N506_RS09490	COG2818	Glycosylase
N506_RS09565	COG1122	ATPase activity
N506_RS09570	COG1122	ATPase activity
N506_RS09575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N506_RS09595	COG1335	isochorismatase
N506_RS09600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP