locus-tag	class	description
HUO_RS00015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUO_RS00035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO_RS00050	COG1268	BioY protein
HUO_RS00060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUO_RS00065	COG0825	malonyl-CoA metabolic process
HUO_RS00070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUO_RS00075	COG0439	Biotin carboxylase
HUO_RS00080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUO_RS00085	COG0511	ligase activity, forming carbon-carbon bonds
HUO_RS00090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO_RS00095	COG1028	Short-chain dehydrogenase reductase Sdr
HUO_RS00100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUO_RS00105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO_RS00110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO_RS00120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUO_RS00125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUO_RS00130	COG2261	transglycosylase associated protein
HUO_RS00145	COG4975	Glucose uptake
HUO_RS00220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO_RS00235	COG1122	ATPase activity
HUO_RS00245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUO_RS00265	COG2223	nitrite transmembrane transporter activity
HUO_RS00275	COG1609	Transcriptional regulator
HUO_RS00280	COG2365	Tyrosine phosphatase family
HUO_RS00290	COG0351	phosphomethylpyrimidine kinase
HUO_RS00300	COG3442	glutamine amidotransferase
HUO_RS00305	COG2801	Transposase and inactivated derivatives
HUO_RS00315	COG0697	spore germination
HUO_RS00355	COG0488	(ABC) transporter
HUO_RS00370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUO_RS00375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUO_RS00380	COG0516	GMP reductase activity
HUO_RS00405	COG2502	aspartate--ammonia ligase
HUO_RS00425	COG1113	amino acid transport
HUO_RS00430	COG1113	amino acid transport
HUO_RS00440	COG0681	Belongs to the peptidase S26 family
HUO_RS00445	COG0542	response to heat
HUO_RS00515	COG0656	L-ascorbic acid biosynthetic process
HUO_RS00520	COG0656	L-ascorbic acid biosynthetic process
HUO_RS00535	COG2244	polysaccharide biosynthetic process
HUO_RS00570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO_RS00575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HUO_RS00580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO_RS00585	COG1696	Membrane protein involved in D-alanine export
HUO_RS00590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO_RS00620	COG2217	Heavy metal translocating P-type atpase
HUO_RS00635	COG2161	toxin-antitoxin pair type II binding
HUO_RS00640	COG4115	mRNA cleavage
HUO_RS00645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUO_RS00685	COG0656	L-ascorbic acid biosynthetic process
HUO_RS00690	COG0363	glucosamine-6-phosphate deaminase activity
HUO_RS00715	COG1428	Deoxynucleoside kinase
HUO_RS00720	COG1428	Deoxynucleoside kinase
HUO_RS00730	COG2252	PERMEase
HUO_RS00735	COG1373	ATPase (AAA superfamily
HUO_RS00745	COG1373	ATPase (AAA superfamily
HUO_RS00755	COG2252	PERMEase
HUO_RS00770	COG0004	ammonium transporteR
HUO_RS00780	COG2252	PERMEase
HUO_RS00805	COG2217	Heavy metal translocating P-type atpase
HUO_RS00825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUO_RS00830	COG0445	tRNA wobble uridine modification
HUO_RS00835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUO_RS00840	COG0706	membrane insertase activity
HUO_RS00845	COG0594	ribonuclease P activity
HUO_RS00850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUO_RS00855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUO_RS00860	COG0592	DNA-directed DNA polymerase activity
HUO_RS00865	COG2501	S4 domain
HUO_RS00870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUO_RS00875	COG0187	DNA topoisomerase II activity
HUO_RS00880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUO_RS00885	COG0360	Binds together with S18 to 16S ribosomal RNA
HUO_RS00890	COG0629	single-stranded DNA binding
HUO_RS00895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUO_RS00905	COG1132	(ABC) transporter
HUO_RS00940	COG0515	serine threonine protein kinase
HUO_RS00965	COG0359	binds to the 23S rRNA
HUO_RS00970	COG0305	Participates in initiation and elongation during chromosome replication
HUO_RS00990	COG1307	EDD domain protein, DegV family
HUO_RS00995	COG1940	carbohydrate kinase activity
HUO_RS01000	COG2261	transglycosylase associated protein
HUO_RS01020	COG1285	pathogenesis
HUO_RS01085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUO_RS01135	COG4619	ABC transporter
HUO_RS01140	COG0390	transport system, permease component
HUO_RS01180	COG2096	Adenosyltransferase
HUO_RS01195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUO_RS01200	COG0628	permease
HUO_RS01220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUO_RS01235	COG1011	Hydrolase
HUO_RS01255	COG0656	L-ascorbic acid biosynthetic process
HUO_RS01265	COG0561	phosphatase activity
HUO_RS01270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUO_RS01275	COG3001	Fructosamine kinase
HUO_RS01290	COG0708	Exodeoxyribonuclease III
HUO_RS01325	COG0242	peptide deformylase activity
HUO_RS01365	COG0583	DNA-binding transcription factor activity
HUO_RS01390	COG1442	glycosyl transferase family 8
HUO_RS01440	COG0745	RESPONSE REGULATOR receiver
HUO_RS01445	COG5002	protein histidine kinase activity
HUO_RS01460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUO_RS01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO_RS01470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUO_RS01480	COG2267	carboxylic ester hydrolase activity
HUO_RS01510	COG0501	Belongs to the peptidase M48B family
HUO_RS01515	COG1704	LemA family
HUO_RS01520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUO_RS01545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUO_RS01580	COG1126	abc transporter atp-binding protein
HUO_RS01585	COG0765	amino acid transport
HUO_RS01605	COG2094	Belongs to the DNA glycosylase MPG family
HUO_RS01610	COG3189	MarR family transcriptional regulator
HUO_RS01615	COG0861	Integral membrane protein TerC family
HUO_RS01620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUO_RS01625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUO_RS01635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO_RS01645	COG0328	RNA-DNA hybrid ribonuclease activity
HUO_RS01655	COG2801	Transposase and inactivated derivatives
HUO_RS01665	COG1216	Glycosyl transferase, family 2
HUO_RS01685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUO_RS01700	COG0765	amino acid transport
HUO_RS01705	COG1126	abc transporter atp-binding protein
HUO_RS01715	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUO_RS01765	COG2365	Tyrosine phosphatase family
HUO_RS01770	COG0589	response to stress
HUO_RS01780	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUO_RS01790	COG3639	organic phosphonate transmembrane transporter activity
HUO_RS01795	COG0519	Catalyzes the synthesis of GMP from XMP
HUO_RS01810	COG0367	asparagine synthase
HUO_RS01825	COG0602	queuosine metabolic process
HUO_RS01830	COG2151	metal-sulfur cluster biosynthetic enzyme
HUO_RS01840	COG2814	Major facilitator Superfamily
HUO_RS01845	COG3590	peptidase
HUO_RS01850	COG3158	transport of potassium into the cell
HUO_RS01890	COG1388	LysM domain
HUO_RS01890	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUO_RS01900	COG0569	domain protein
HUO_RS01900	COG0475	glutathione-regulated potassium exporter activity
HUO_RS01910	COG0673	inositol 2-dehydrogenase activity
HUO_RS01925	COG0588	phosphoglycerate mutase activity
HUO_RS01930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUO_RS01940	COG1316	TRANSCRIPTIONal
HUO_RS01945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUO_RS01950	COG1368	sulfuric ester hydrolase activity
HUO_RS01960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUO_RS01975	COG3579	cysteine-type endopeptidase activity
HUO_RS01980	COG1418	mRNA catabolic process
HUO_RS01985	COG4166	transmembrane transport
HUO_RS01990	COG4166	transmembrane transport
HUO_RS01995	COG0517	IMP dehydrogenase activity
HUO_RS01995	COG0516	GMP reductase activity
HUO_RS02000	COG0601	transmembrane transport
HUO_RS02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO_RS02010	COG0444	Belongs to the ABC transporter superfamily
HUO_RS02015	COG4608	Belongs to the ABC transporter superfamily
HUO_RS02020	COG2801	Transposase and inactivated derivatives
HUO_RS02025	COG3579	cysteine-type endopeptidase activity
HUO_RS02035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUO_RS02060	COG2131	deaminase
HUO_RS02070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS02075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO_RS02075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO_RS02080	COG0084	hydrolase, TatD family'
HUO_RS02090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUO_RS02095	COG4466	Protein conserved in bacteria
HUO_RS02100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO_RS02105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUO_RS02130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUO_RS02145	COG1078	dGTPase activity
HUO_RS02155	COG3343	RNA polymerase activity
HUO_RS02160	COG0504	CTP synthase activity
HUO_RS02165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUO_RS02175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO_RS02180	COG4690	dipeptidase activity
HUO_RS02190	COG2233	PERMEase
HUO_RS02195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO_RS02225	COG0519	Catalyzes the synthesis of GMP from XMP
HUO_RS02240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUO_RS02300	COG0561	phosphatase activity
HUO_RS02305	COG0254	rRNA binding
HUO_RS02310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUO_RS02320	COG0736	holo-[acyl-carrier-protein] synthase activity
HUO_RS02325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUO_RS02340	COG0039	L-malate dehydrogenase activity
HUO_RS02345	COG0193	aminoacyl-tRNA hydrolase activity
HUO_RS02350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUO_RS02370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUO_RS02385	COG0037	tRNA processing
HUO_RS02395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUO_RS02400	COG2801	Transposase and inactivated derivatives
HUO_RS02405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO_RS02410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUO_RS02435	COG1956	GAF domain-containing protein
HUO_RS02440	COG0542	response to heat
HUO_RS02445	COG0085	RNA polymerase activity
HUO_RS02450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUO_RS02475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUO_RS02480	COG0049	tRNA binding
HUO_RS02485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUO_RS02490	COG0051	transcription antitermination factor activity, RNA binding
HUO_RS02495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUO_RS02500	COG0088	Forms part of the polypeptide exit tunnel
HUO_RS02505	COG0089	rRNA binding
HUO_RS02510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUO_RS02515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUO_RS02520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUO_RS02525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUO_RS02530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUO_RS02535	COG0255	Belongs to the universal ribosomal protein uL29 family
HUO_RS02540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUO_RS02545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUO_RS02550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUO_RS02555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUO_RS02565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUO_RS02570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUO_RS02575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUO_RS02580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUO_RS02585	COG1841	ribosomal large subunit assembly
HUO_RS02590	COG0200	Binds to the 23S rRNA
HUO_RS02600	COG0563	adenylate kinase activity
HUO_RS02605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUO_RS02610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUO_RS02615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUO_RS02620	COG0202	RNA polymerase activity
HUO_RS02625	COG0203	ribosomal protein L17
HUO_RS02630	COG1122	ATPase activity
HUO_RS02635	COG1122	ATPase activity
HUO_RS02640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUO_RS02645	COG0101	tRNA pseudouridine synthase activity
HUO_RS02650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUO_RS02685	COG1230	cation diffusion facilitator family transporter
HUO_RS02695	COG0588	phosphoglycerate mutase activity
HUO_RS02710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS02720	COG4975	Glucose uptake
HUO_RS02750	COG0756	dUTP diphosphatase activity
HUO_RS02760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUO_RS02765	COG0215	cysteine-tRNA ligase activity
HUO_RS02770	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUO_RS02775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO_RS02790	COG1070	Carbohydrate kinase
HUO_RS02805	COG0250	Participates in transcription elongation, termination and antitermination
HUO_RS02810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUO_RS02815	COG0081	regulation of translation
HUO_RS02840	COG0573	inorganic phosphate transmembrane transporter activity
HUO_RS02845	COG0581	inorganic phosphate transmembrane transporter activity
HUO_RS02850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO_RS02860	COG0704	Plays a role in the regulation of phosphate uptake
HUO_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUO_RS02880	COG0222	ribosome binding
HUO_RS02890	COG2813	Specifically methylates the guanine in position
HUO_RS02895	COG0590	tRNA wobble adenosine to inosine editing
HUO_RS02900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUO_RS02905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUO_RS02910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUO_RS02920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUO_RS02925	COG3870	Protein conserved in bacteria
HUO_RS02930	COG0470	DNA polymerase III
HUO_RS02950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HUO_RS02955	COG1214	PFAM Peptidase M22, glycoprotease
HUO_RS02960	COG0456	acetyltransferase
HUO_RS02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUO_RS03000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUO_RS03010	COG0488	(ABC) transporter
HUO_RS03015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUO_RS03060	COG1472	Belongs to the glycosyl hydrolase 3 family
HUO_RS03080	COG0582	viral genome integration into host DNA
HUO_RS03085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUO_RS03090	COG0459	protein refolding
HUO_RS03095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUO_RS03100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUO_RS03105	COG0632	four-way junction helicase activity
HUO_RS03110	COG2255	four-way junction helicase activity
HUO_RS03120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUO_RS03125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUO_RS03130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUO_RS03135	COG0513	Belongs to the DEAD box helicase family
HUO_RS03150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUO_RS03155	COG4472	Bacterial protein of unknown function (DUF965)
HUO_RS03160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUO_RS03165	COG3906	Belongs to the UPF0473 family
HUO_RS03170	COG1193	negative regulation of DNA recombination
HUO_RS03175	COG3118	belongs to the thioredoxin family
HUO_RS03180	COG1970	mechanosensitive ion channel activity
HUO_RS03195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUO_RS03200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUO_RS03215	COG0668	transmembrane transport
HUO_RS03240	COG0006	proline dipeptidase activity
HUO_RS03260	COG0737	Belongs to the 5'-nucleotidase family
HUO_RS03270	COG0647	UMP catabolic process
HUO_RS03280	COG0586	Pfam SNARE associated Golgi protein
HUO_RS03285	COG0492	ferredoxin-NADP+ reductase activity
HUO_RS03450	COG0438	transferase activity, transferring glycosyl groups
HUO_RS03455	COG0438	transferase activity, transferring glycosyl groups
HUO_RS03465	COG1368	sulfuric ester hydrolase activity
HUO_RS03470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUO_RS03475	COG0557	exoribonuclease II activity
HUO_RS03480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUO_RS03535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUO_RS03540	COG2814	Major facilitator Superfamily
HUO_RS03545	COG0142	geranyltranstransferase activity
HUO_RS03560	COG0671	phosphoesterase, PA-phosphatase related
HUO_RS03565	COG0495	leucyl-tRNA aminoacylation
HUO_RS03570	COG2244	polysaccharide biosynthetic process
HUO_RS03615	COG0492	ferredoxin-NADP+ reductase activity
HUO_RS03635	COG1983	PspC domain protein
HUO_RS03645	COG1686	Belongs to the peptidase S11 family
HUO_RS03650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUO_RS03655	COG1376	ErfK ybiS ycfS ynhG family protein
HUO_RS03665	COG3479	Phenolic acid decarboxylase
HUO_RS03680	COG0018	arginyl-trna synthetase
HUO_RS03710	COG1132	(ABC) transporter
HUO_RS03775	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HUO_RS03785	COG2801	Transposase and inactivated derivatives
HUO_RS03790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUO_RS03800	COG2723	6-phospho-beta-galactosidase activity
HUO_RS03805	COG0564	pseudouridine synthase activity
HUO_RS03810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO_RS03815	COG3679	Belongs to the UPF0342 family
HUO_RS03820	COG0420	3'-5' exonuclease activity
HUO_RS03830	COG3481	metal-dependent phosphohydrolase, HD sub domain
HUO_RS03845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO_RS03855	COG0537	adenosine 5'-monophosphoramidase activity
HUO_RS03870	COG1131	(ABC) transporter
HUO_RS03880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUO_RS03885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO_RS03890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO_RS03920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUO_RS04040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO_RS04040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO_RS04045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUO_RS04050	COG0237	dephospho-CoA kinase activity
HUO_RS04055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUO_RS04065	COG1484	DNA-dependent DNA replication
HUO_RS04070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUO_RS04105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUO_RS04110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUO_RS04115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUO_RS04120	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUO_RS04125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUO_RS04130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUO_RS04135	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUO_RS04140	COG0799	negative regulation of ribosome biogenesis
HUO_RS04145	COG1323	Belongs to the UPF0348 family
HUO_RS04155	COG0745	RESPONSE REGULATOR receiver
HUO_RS04160	COG5002	protein histidine kinase activity
HUO_RS04165	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HUO_RS04170	COG0706	membrane insertase activity
HUO_RS04175	COG1254	Belongs to the acylphosphatase family
HUO_RS04180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO_RS04185	COG1733	regulation of RNA biosynthetic process
HUO_RS04190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUO_RS04195	COG0072	phenylalanine-tRNA ligase activity
HUO_RS04220	COG2801	Transposase and inactivated derivatives
HUO_RS04235	COG2971	BadF BadG BcrA BcrD
HUO_RS04245	COG0768	penicillin binding
HUO_RS04250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUO_RS04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUO_RS04270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO_RS04275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUO_RS04330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUO_RS04335	COG3250	beta-galactosidase activity
HUO_RS04340	COG3250	beta-galactosidase activity
HUO_RS04345	COG1609	Transcriptional regulator
HUO_RS04350	COG2190	(PTS) system
HUO_RS04350	COG2211	Major facilitator Superfamily
HUO_RS04355	COG2211	Major facilitator Superfamily
HUO_RS04355	COG2190	(PTS) system
HUO_RS04360	COG2211	Major facilitator Superfamily
HUO_RS04360	COG2190	(PTS) system
HUO_RS04365	COG2211	Major facilitator Superfamily
HUO_RS04365	COG2190	(PTS) system
HUO_RS04370	COG2211	Major facilitator Superfamily
HUO_RS04370	COG2190	(PTS) system
HUO_RS04380	COG2801	Transposase and inactivated derivatives
HUO_RS04390	COG0738	Major facilitator superfamily
HUO_RS04395	COG0710	3-dehydroquinate dehydratase activity
HUO_RS04400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUO_RS04405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUO_RS04410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUO_RS04415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUO_RS04420	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUO_RS04425	COG0047	phosphoribosylformylglycinamidine synthase activity
HUO_RS04430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUO_RS04440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUO_RS04445	COG0138	bifunctional purine biosynthesis protein purh
HUO_RS04450	COG0151	Belongs to the GarS family
HUO_RS04465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUO_RS04475	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUO_RS04480	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUO_RS04485	COG3845	ABC transporter
HUO_RS04490	COG1744	ABC transporter substrate-binding protein PnrA-like
HUO_RS04515	COG2814	Major facilitator Superfamily
HUO_RS04520	COG0737	Belongs to the 5'-nucleotidase family
HUO_RS04540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUO_RS04545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUO_RS04550	COG2017	converts alpha-aldose to the beta-anomer
HUO_RS04570	COG0745	RESPONSE REGULATOR receiver
HUO_RS04610	COG2801	Transposase and inactivated derivatives
HUO_RS04625	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUO_RS04635	COG0732	type I restriction modification DNA specificity domain
HUO_RS04720	COG1857	crispr-associated protein
HUO_RS04735	COG1518	maintenance of DNA repeat elements
HUO_RS04740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUO_RS04770	COG4372	Transposase
HUO_RS04815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS04825	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUO_RS04835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUO_RS04840	COG0284	orotidine-5'-phosphate decarboxylase activity
HUO_RS04845	COG0167	dihydroorotate dehydrogenase activity
HUO_RS04855	COG0540	Belongs to the ATCase OTCase family
HUO_RS04860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUO_RS04865	COG0505	Belongs to the CarA family
HUO_RS04870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUO_RS04885	COG4975	Glucose uptake
HUO_RS04900	COG2936	dipeptidyl-peptidase activity
HUO_RS04945	COG1942	4-Oxalocrotonate Tautomerase
HUO_RS04955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO_RS04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO_RS04980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUO_RS04985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUO_RS04990	COG0006	proline dipeptidase activity
HUO_RS04995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUO_RS05000	COG1302	Protein conserved in bacteria
HUO_RS05010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUO_RS05020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUO_RS05025	COG1570	exodeoxyribonuclease VII activity
HUO_RS05030	COG1722	exodeoxyribonuclease VII activity
HUO_RS05040	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUO_RS05045	COG0497	DNA recombination
HUO_RS05055	COG0194	GDP metabolic process
HUO_RS05060	COG1758	RNA polymerase activity
HUO_RS05065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUO_RS05070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUO_RS05075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUO_RS05075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUO_RS05085	COG0515	serine threonine protein kinase
HUO_RS05085	COG2815	serine threonine protein kinase
HUO_RS05090	COG1162	GTPase activity
HUO_RS05095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUO_RS05115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUO_RS05125	COG1461	Dihydroxyacetone kinase
HUO_RS05130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUO_RS05135	COG0416	fatty acid biosynthetic process
HUO_RS05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO_RS05150	COG4608	Belongs to the ABC transporter superfamily
HUO_RS05155	COG0601	transmembrane transport
HUO_RS05175	COG0571	ribonuclease III activity
HUO_RS05180	COG1196	nuclear chromosome segregation
HUO_RS05185	COG0552	protein localization to endoplasmic reticulum
HUO_RS05205	COG4372	Transposase
HUO_RS05220	COG0531	amino acid
HUO_RS05230	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HUO_RS05235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUO_RS05240	COG0228	four-way junction DNA binding
HUO_RS05245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUO_RS05250	COG0336	Belongs to the RNA methyltransferase TrmD family
HUO_RS05255	COG0335	large ribosomal subunit rRNA binding
HUO_RS05270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUO_RS05275	COG4224	UPF0291 protein
HUO_RS05285	COG3763	UPF0154 protein
HUO_RS05290	COG1132	(ABC) transporter
HUO_RS05305	COG1132	(ABC) transporter
HUO_RS05310	COG3590	peptidase
HUO_RS05315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUO_RS05320	COG0204	Acyl-transferase
HUO_RS05325	COG2827	Endonuclease containing a URI domain
HUO_RS05330	COG0052	Belongs to the universal ribosomal protein uS2 family
HUO_RS05335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUO_RS05340	COG2801	Transposase and inactivated derivatives
HUO_RS05345	COG0528	UMP kinase activity
HUO_RS05350	COG0233	cytoplasmic translational termination
HUO_RS05355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUO_RS05360	COG4589	Belongs to the CDS family
HUO_RS05365	COG0750	zinc metalloprotease
HUO_RS05370	COG0442	prolyl-tRNA aminoacylation
HUO_RS05380	COG0779	Required for maturation of 30S ribosomal subunits
HUO_RS05385	COG0195	Participates in both transcription termination and antitermination
HUO_RS05390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HUO_RS05400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUO_RS05405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUO_RS05410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUO_RS05415	COG0196	riboflavin kinase activity
HUO_RS05420	COG1420	regulation of RNA biosynthetic process
HUO_RS05425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUO_RS05430	COG0443	Heat shock 70 kDa protein
HUO_RS05435	COG0484	heat shock protein binding
HUO_RS05450	COG0481	GTPase activity
HUO_RS05455	COG3764	Sortase (surface protein transpeptidase)
HUO_RS05460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUO_RS05460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUO_RS05465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO_RS05470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO_RS05490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS05495	COG0583	DNA-binding transcription factor activity
HUO_RS05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO_RS05565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HUO_RS05570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUO_RS05580	COG1702	phosphate starvation-inducible protein PhoH
HUO_RS05585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUO_RS05590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUO_RS05595	COG1381	Involved in DNA repair and RecF pathway recombination
HUO_RS05600	COG0752	glycyl-tRNA synthetase alpha subunit
HUO_RS05605	COG0751	glycine-tRNA ligase activity
HUO_RS05610	COG0358	DNA primase activity
HUO_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUO_RS05635	COG2384	SAM-dependent methyltransferase
HUO_RS05640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUO_RS05645	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO_RS05650	COG1725	Transcriptional regulator
HUO_RS05655	COG1131	(ABC) transporter
HUO_RS05700	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HUO_RS05700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUO_RS05705	COG1304	FMN binding
HUO_RS05720	COG0083	homoserine kinase activity
HUO_RS05725	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HUO_RS05730	COG1074	ATP-dependent DNA helicase activity
HUO_RS05735	COG1199	ATP-dependent helicase activity
HUO_RS05735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUO_RS05745	COG0017	Asparaginyl-tRNA synthetase
HUO_RS05750	COG3935	DnaD domain protein
HUO_RS05755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUO_RS05765	COG3331	DNA recombination
HUO_RS05770	COG4474	Belongs to the UPF0398 family
HUO_RS05775	COG3599	regulation of cell shape
HUO_RS05780	COG0116	Belongs to the methyltransferase superfamily
HUO_RS05795	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUO_RS05805	COG0564	pseudouridine synthase activity
HUO_RS05810	COG0505	Belongs to the CarA family
HUO_RS05815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUO_RS05830	COG1307	EDD domain protein, DegV family
HUO_RS05845	COG4372	Transposase
HUO_RS05850	COG1307	EDD domain protein, DegV family
HUO_RS05860	COG4974	Belongs to the 'phage' integrase family
HUO_RS05870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUO_RS05915	COG3590	peptidase
HUO_RS05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO_RS05965	COG1227	inorganic diphosphatase activity
HUO_RS05970	COG0583	DNA-binding transcription factor activity
HUO_RS05980	COG0187	DNA topoisomerase II activity
HUO_RS05985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUO_RS05990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUO_RS05995	COG0783	Belongs to the Dps family
HUO_RS06025	COG3830	Belongs to the UPF0237 family
HUO_RS06030	COG0778	Nitroreductase
HUO_RS06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO_RS06105	COG1126	abc transporter atp-binding protein
HUO_RS06110	COG0765	amino acid transport
HUO_RS06115	COG0765	amino acid transport
HUO_RS06140	COG1051	belongs to the nudix hydrolase family
HUO_RS06145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUO_RS06150	COG0285	dihydrofolate synthase activity
HUO_RS06155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUO_RS06155	COG0302	gtp cyclohydrolase
HUO_RS06200	COG1733	regulation of RNA biosynthetic process
HUO_RS06205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUO_RS06210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO_RS06220	COG2801	Transposase and inactivated derivatives
HUO_RS06225	COG1114	Component of the transport system for branched-chain amino acids
HUO_RS06290	COG1473	amidohydrolase
HUO_RS06295	COG0531	amino acid
HUO_RS06305	COG3590	peptidase
HUO_RS06340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUO_RS06355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HUO_RS06370	COG2217	Heavy metal translocating P-type atpase
HUO_RS06390	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUO_RS06430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUO_RS06480	COG1132	(ABC) transporter
HUO_RS06495	COG1127	ABC transporter
HUO_RS06510	COG0488	(ABC) transporter
HUO_RS06525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUO_RS06535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUO_RS06540	COG0456	acetyltransferase
HUO_RS06555	COG2801	Transposase and inactivated derivatives
HUO_RS06570	COG4372	Transposase
HUO_RS06665	COG1132	(ABC) transporter
HUO_RS06670	COG2274	protein secretion by the type I secretion system
HUO_RS06690	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO_RS06695	COG0534	Mate efflux family protein
HUO_RS06715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO_RS06735	COG0514	ATP-dependent DNA helicase (RecQ)
HUO_RS06745	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HUO_RS06765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUO_RS06770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUO_RS06795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUO_RS06810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HUO_RS06815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO_RS06820	COG0758	DNA mediated transformation
HUO_RS06825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUO_RS06830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUO_RS06835	COG0025	NhaP-type Na H and K H
HUO_RS06840	COG4479	Belongs to the UPF0346 family
HUO_RS06845	COG1307	EDD domain protein, DegV family
HUO_RS06850	COG1272	protein, Hemolysin III
HUO_RS06855	COG0617	tRNA 3'-terminal CCA addition
HUO_RS06860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO_RS06875	COG1160	GTP binding
HUO_RS06880	COG0539	negative regulation of cytoplasmic translation
HUO_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUO_RS06915	COG1187	pseudouridine synthase activity
HUO_RS06920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUO_RS06925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUO_RS06930	COG0456	acetyltransferase
HUO_RS06940	COG2996	Protein conserved in bacteria
HUO_RS06950	COG0205	6-phosphofructokinase activity
HUO_RS06955	COG0587	DNA-directed DNA polymerase activity
HUO_RS06965	COG0737	Belongs to the 5'-nucleotidase family
HUO_RS06970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUO_RS06980	COG0300	oxidoreductase activity
HUO_RS06985	COG1234	tRNA 3'-trailer cleavage
HUO_RS06995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUO_RS07000	COG0322	excinuclease ABC activity
HUO_RS07010	COG0531	amino acid
HUO_RS07030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUO_RS07040	COG0436	Aminotransferase
HUO_RS07045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUO_RS07050	COG0124	histidyl-tRNA synthetase
HUO_RS07055	COG1490	D-aminoacyl-tRNA deacylase activity
HUO_RS07060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUO_RS07070	COG2264	protein methyltransferase activity
HUO_RS07075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUO_RS07100	COG1881	PFAM PEBP family protein
HUO_RS07125	COG4720	Psort location CytoplasmicMembrane, score
HUO_RS07130	COG1122	ATPase activity
HUO_RS07140	COG2707	UPF0756 membrane protein
HUO_RS07165	COG3052	prosthetic group binding
HUO_RS07175	COG2267	carboxylic ester hydrolase activity
HUO_RS07180	COG0471	metal ion transport
HUO_RS07190	COG3579	cysteine-type endopeptidase activity
HUO_RS07205	COG0039	L-malate dehydrogenase activity
HUO_RS07250	COG0114	fumarate hydratase activity
HUO_RS07295	COG1373	ATPase (AAA superfamily
HUO_RS07300	COG2011	ABC-type metal ion transport system permease component
HUO_RS07305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUO_RS07315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS07330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUO_RS07335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUO_RS07345	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HUO_RS07365	COG0148	phosphopyruvate hydratase activity
HUO_RS07395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO_RS07405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO_RS07410	COG2188	Transcriptional regulator
HUO_RS07430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUO_RS07435	COG1335	isochorismatase
HUO_RS07460	COG2801	Transposase and inactivated derivatives
HUO_RS07465	COG4989	oxidoreductase activity
HUO_RS07470	COG1957	nucleoside hydrolase
HUO_RS07490	COG1051	belongs to the nudix hydrolase family
HUO_RS07495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO_RS07500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUO_RS07510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUO_RS07515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUO_RS07520	COG1473	amidohydrolase
HUO_RS07525	COG2171	N-acyltransferase activity
HUO_RS07530	COG0019	diaminopimelate decarboxylase activity
HUO_RS07545	COG0527	aspartate kinase activity
HUO_RS07550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUO_RS07560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUO_RS07565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUO_RS07570	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUO_RS07575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUO_RS07590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUO_RS07595	COG0268	Binds directly to 16S ribosomal RNA
HUO_RS07600	COG1466	dna polymerase III delta subunit
HUO_RS07605	COG0658	competence protein
HUO_RS07605	COG2333	competence protein COMEC
HUO_RS07610	COG1555	photosystem II stabilization
HUO_RS07615	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUO_RS07620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUO_RS07625	COG0742	ribosomal rna small subunit methyltransferase
HUO_RS07635	COG0772	Belongs to the SEDS family
HUO_RS07640	COG1217	gtp-binding protein TYPA
HUO_RS07645	COG0242	peptide deformylase activity
HUO_RS07650	COG5503	Protein of unknown function (DUF1447)
HUO_RS07665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUO_RS07675	COG0406	alpha-ribazole phosphatase activity
HUO_RS07680	COG0482	sulfurtransferase activity
HUO_RS07690	COG1104	cysteine desulfurase activity
HUO_RS07695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUO_RS07705	COG0494	nUDIX hydrolase
HUO_RS07710	COG1278	Cold shock
HUO_RS07715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUO_RS07735	COG1799	cell septum assembly
HUO_RS07740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUO_RS07750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUO_RS07755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUO_RS07760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUO_RS07765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUO_RS07780	COG0275	rRNA processing
HUO_RS07785	COG2001	Belongs to the MraZ family
HUO_RS07815	COG1792	Involved in formation and maintenance of cell shape
HUO_RS07820	COG1077	Cell shape determining protein MreB Mrl
HUO_RS07825	COG2003	Belongs to the UPF0758 family
HUO_RS07830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO_RS07840	COG0525	valine-tRNA ligase activity
HUO_RS07860	COG0463	Glycosyl transferase, family 2
HUO_RS07885	COG1187	pseudouridine synthase activity
HUO_RS08040	COG1187	pseudouridine synthase activity
HUO_RS08050	COG0301	tRNA thio-modification
HUO_RS08055	COG1104	cysteine desulfurase activity
HUO_RS08060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HUO_RS08065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUO_RS08075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUO_RS08085	COG0589	response to stress
HUO_RS08090	COG0772	Belongs to the SEDS family
HUO_RS08110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUO_RS08115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUO_RS08120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUO_RS08125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUO_RS08130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUO_RS08135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUO_RS08140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUO_RS08145	COG0356	it plays a direct role in the translocation of protons across the membrane
HUO_RS08150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUO_RS08155	COG0009	L-threonylcarbamoyladenylate synthase
HUO_RS08160	COG2890	protein-(glutamine-N5) methyltransferase activity
HUO_RS08165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUO_RS08170	COG1435	thymidine kinase activity
HUO_RS08175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUO_RS08190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO_RS08205	COG0166	Belongs to the GPI family
HUO_RS08215	COG1368	sulfuric ester hydrolase activity
HUO_RS08225	COG5002	protein histidine kinase activity
HUO_RS08225	COG3850	Histidine kinase
HUO_RS08230	COG0745	RESPONSE REGULATOR receiver
HUO_RS08240	COG1482	cell wall glycoprotein biosynthetic process
HUO_RS08255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUO_RS08260	COG0827	DNA restriction-modification system
HUO_RS08290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO_RS08295	COG0217	transcriptional regulatory protein
HUO_RS08320	COG2801	Transposase and inactivated derivatives
HUO_RS08335	COG2190	(PTS) system
HUO_RS08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO_RS08335	COG1263	PTS System
HUO_RS08345	COG1929	Belongs to the glycerate kinase type-1 family
HUO_RS08350	COG4372	Transposase
HUO_RS08380	COG0561	phosphatase activity
HUO_RS08385	COG0561	phosphatase activity
HUO_RS08390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO_RS08395	COG4856	YbbR-like protein
HUO_RS08410	COG4208	sulfate ABC transporter
HUO_RS08415	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUO_RS08420	COG3842	ATPase activity
HUO_RS08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUO_RS08435	COG0802	atpase or kinase
HUO_RS08440	COG0280	phosphate acetyltransferase
HUO_RS08445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUO_RS08450	COG0561	phosphatase activity
HUO_RS08460	COG0149	triose-phosphate isomerase activity
HUO_RS08465	COG0126	phosphoglycerate kinase activity
HUO_RS08475	COG2390	Transcriptional regulator
HUO_RS08560	COG2801	Transposase and inactivated derivatives
HUO_RS08570	COG0740	serine-type endopeptidase activity
HUO_RS08575	COG1481	regulation of sporulation
HUO_RS08580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUO_RS08585	COG1660	Displays ATPase and GTPase activities
HUO_RS08600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUO_RS08605	COG0556	nucleotide-excision repair
HUO_RS08610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO_RS08615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUO_RS08620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUO_RS08625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUO_RS08630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUO_RS08640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUO_RS08645	COG0653	protein targeting
HUO_RS08660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUO_RS08665	COG1739	Uncharacterized protein family UPF0029
HUO_RS08670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUO_RS08675	COG1418	mRNA catabolic process
HUO_RS08680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUO_RS08685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUO_RS08690	COG1426	Protein conserved in bacteria
HUO_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
HUO_RS08700	COG0612	Peptidase, M16
HUO_RS08710	COG1674	ftsk spoiiie
HUO_RS08725	COG0628	permease
HUO_RS08735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO_RS08740	COG2706	6-phosphogluconolactonase activity
HUO_RS08755	COG0564	pseudouridine synthase activity
HUO_RS08760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUO_RS08765	COG2357	RelA SpoT domain protein
HUO_RS08785	COG4862	establishment of competence for transformation
HUO_RS08790	COG1393	Belongs to the ArsC family
HUO_RS08815	COG0542	response to heat
HUO_RS08825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUO_RS08830	COG1253	flavin adenine dinucleotide binding
HUO_RS08850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUO_RS08870	COG3425	synthase
HUO_RS08880	COG0183	Belongs to the thiolase family
HUO_RS08890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUO_RS08895	COG1295	ribonuclease BN
HUO_RS08900	COG0024	Methionine aminopeptidase
HUO_RS08905	COG0716	FMN binding
HUO_RS08915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUO_RS08930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO_RS08935	COG0513	Belongs to the DEAD box helicase family
HUO_RS08955	COG0531	amino acid
HUO_RS08965	COG1253	flavin adenine dinucleotide binding
HUO_RS08990	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUO_RS08995	COG1349	DNA-binding transcription factor activity
HUO_RS09005	COG2151	metal-sulfur cluster biosynthetic enzyme
HUO_RS09010	COG0719	Fe-S assembly protein
HUO_RS09015	COG0822	iron-sulfur transferase activity
HUO_RS09020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUO_RS09025	COG0719	Fe-S assembly protein
HUO_RS09040	COG0561	phosphatase activity
HUO_RS09070	COG3158	transport of potassium into the cell
HUO_RS09075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUO_RS09105	COG3830	Belongs to the UPF0237 family
HUO_RS09110	COG2848	UPF0210 protein
HUO_RS09130	COG0765	amino acid transport
HUO_RS09135	COG0765	amino acid transport
HUO_RS09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO_RS09155	COG1132	(ABC) transporter
HUO_RS09160	COG1132	(ABC) transporter
HUO_RS09170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO_RS09175	COG0519	Catalyzes the synthesis of GMP from XMP
HUO_RS09185	COG0488	(ABC) transporter
HUO_RS09200	COG0477	Major facilitator Superfamily
HUO_RS09265	COG1278	Cold shock
HUO_RS09275	COG0516	GMP reductase activity
HUO_RS09275	COG0517	IMP dehydrogenase activity
HUO_RS09280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUO_RS09285	COG0436	Aminotransferase
HUO_RS09290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUO_RS09300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUO_RS09305	COG1757	Na H antiporter
HUO_RS09315	COG0670	Belongs to the BI1 family
HUO_RS09325	COG1597	lipid kinase activity
HUO_RS09330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUO_RS09335	COG0154	amidase activity
HUO_RS09340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUO_RS09345	COG4851	CamS sex pheromone cAM373 precursor
HUO_RS09350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUO_RS09360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUO_RS09370	COG3091	SprT-like family
HUO_RS09385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUO_RS09405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUO_RS09415	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUO_RS09425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUO_RS09430	COG2188	Transcriptional regulator
HUO_RS09490	COG0588	phosphoglycerate mutase activity
HUO_RS09540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUO_RS09555	COG2188	Transcriptional regulator
HUO_RS09620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUO_RS09645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUO_RS09650	COG1454	alcohol dehydrogenase
HUO_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
HUO_RS09655	COG1113	amino acid transport
HUO_RS09660	COG0110	maltose O-acetyltransferase activity
HUO_RS09675	COG3716	PTS system mannose fructose sorbose family IID component
HUO_RS09680	COG3715	PTS system
HUO_RS09705	COG2207	Transcriptional regulator
HUO_RS09735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUO_RS09740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO_RS09745	COG0398	Pfam SNARE associated Golgi protein
HUO_RS09765	COG1012	belongs to the aldehyde dehydrogenase family
HUO_RS09775	COG2409	Drug exporters of the RND superfamily
HUO_RS09775	COG1033	growth of symbiont in host cell
HUO_RS09820	COG1175	transmembrane transport
HUO_RS09870	COG1132	(ABC) transporter
HUO_RS09875	COG2267	carboxylic ester hydrolase activity
HUO_RS09880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUO_RS09910	COG1653	transport
HUO_RS09915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUO_RS09935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO_RS09940	COG1126	abc transporter atp-binding protein
HUO_RS09945	COG0765	amino acid transport
HUO_RS09950	COG3973	AAA domain
HUO_RS09960	COG0588	phosphoglycerate mutase activity
HUO_RS09970	COG1136	(ABC) transporter
HUO_RS09985	COG0252	asparaginase activity
HUO_RS10005	COG0531	amino acid
HUO_RS10015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUO_RS10040	COG1442	glycosyl transferase family 8
HUO_RS10040	COG1216	Glycosyl transferase, family 2
HUO_RS10060	COG1216	Glycosyl transferase, family 2
HUO_RS10060	COG1442	glycosyl transferase family 8
HUO_RS10065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUO_RS10070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUO_RS10070	COG0463	Glycosyl transferase, family 2
HUO_RS10085	COG0438	transferase activity, transferring glycosyl groups
HUO_RS10090	COG0438	transferase activity, transferring glycosyl groups
HUO_RS10095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUO_RS10100	COG4464	protein tyrosine phosphatase activity
HUO_RS10105	COG0489	protein tyrosine kinase activity
HUO_RS10115	COG1316	TRANSCRIPTIONal
HUO_RS10120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUO_RS10145	COG2801	Transposase and inactivated derivatives
HUO_RS10150	COG0791	NLP P60 protein
HUO_RS10220	COG0488	(ABC) transporter
HUO_RS10240	COG1316	TRANSCRIPTIONal
HUO_RS10245	COG1164	Oligoendopeptidase f
HUO_RS10265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUO_RS10270	COG1121	(ABC) transporter
HUO_RS10280	COG0640	Transcriptional regulator
HUO_RS10285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO_RS10285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO_RS10285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO_RS10290	COG1105	Belongs to the carbohydrate kinase PfkB family
HUO_RS10295	COG1349	DNA-binding transcription factor activity
HUO_RS10320	COG3655	Transcriptional regulator
HUO_RS10345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUO_RS10360	COG1132	(ABC) transporter
HUO_RS10375	COG0012	GTP binding
HUO_RS10380	COG4481	Protein conserved in bacteria
HUO_RS10385	COG1475	DNA binding
HUO_RS10390	COG1192	Involved in chromosome partitioning
HUO_RS10400	COG0357	Ribosomal RNA small subunit methyltransferase G
HUO_RS10420	COG0431	NADPH-dependent FMN reductase
HUO_RS10425	COG0431	NADPH-dependent FMN reductase
HUO_RS10460	COG1136	(ABC) transporter
HUO_RS10465	COG0577	efflux transmembrane transporter activity
HUO_RS10475	COG0406	alpha-ribazole phosphatase activity
HUO_RS10485	COG3022	response to hydroperoxide
HUO_RS10510	COG0308	aminopeptidase N
HUO_RS10520	COG2801	Transposase and inactivated derivatives
HUO_RS10550	COG1132	(ABC) transporter
HUO_RS10610	COG1045	serine acetyltransferase
HUO_RS10615	COG0626	cystathionine gamma-synthase activity
HUO_RS10620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO_RS10655	COG1132	(ABC) transporter
HUO_RS10690	COG2801	Transposase and inactivated derivatives