locus-tag	class	description
BC335_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC335_RS00010	COG0592	DNA-directed DNA polymerase activity
BC335_RS00015	COG2501	S4 domain
BC335_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC335_RS00025	COG0187	DNA topoisomerase II activity
BC335_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC335_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
BC335_RS00040	COG0629	single-stranded DNA binding
BC335_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC335_RS00055	COG1132	(ABC) transporter
BC335_RS00080	COG0359	binds to the 23S rRNA
BC335_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
BC335_RS00090	COG4372	Transposase
BC335_RS00115	COG1307	EDD domain protein, DegV family
BC335_RS00125	COG2801	Transposase and inactivated derivatives
BC335_RS00135	COG1285	pathogenesis
BC335_RS00160	COG4619	ABC transporter
BC335_RS00165	COG0390	transport system, permease component
BC335_RS00210	COG2096	Adenosyltransferase
BC335_RS00225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC335_RS00250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC335_RS00265	COG1011	Hydrolase
BC335_RS00290	COG0656	L-ascorbic acid biosynthetic process
BC335_RS00300	COG0561	phosphatase activity
BC335_RS00305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC335_RS00310	COG3001	Fructosamine kinase
BC335_RS00325	COG0708	Exodeoxyribonuclease III
BC335_RS00385	COG0583	DNA-binding transcription factor activity
BC335_RS00410	COG1442	glycosyl transferase family 8
BC335_RS00460	COG0745	RESPONSE REGULATOR receiver
BC335_RS00465	COG5002	protein histidine kinase activity
BC335_RS00480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC335_RS00485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC335_RS00490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BC335_RS00505	COG2267	carboxylic ester hydrolase activity
BC335_RS00540	COG0501	Belongs to the peptidase M48B family
BC335_RS00545	COG1704	LemA family
BC335_RS00550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC335_RS00610	COG1126	abc transporter atp-binding protein
BC335_RS00615	COG0765	amino acid transport
BC335_RS00620	COG2094	Belongs to the DNA glycosylase MPG family
BC335_RS00625	COG3189	MarR family transcriptional regulator
BC335_RS00630	COG0861	Integral membrane protein TerC family
BC335_RS00635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC335_RS00640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BC335_RS00650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC335_RS00660	COG0328	RNA-DNA hybrid ribonuclease activity
BC335_RS00670	COG1216	Glycosyl transferase, family 2
BC335_RS00690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC335_RS00705	COG0765	amino acid transport
BC335_RS00710	COG1126	abc transporter atp-binding protein
BC335_RS00725	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC335_RS00770	COG2365	Tyrosine phosphatase family
BC335_RS00775	COG0589	response to stress
BC335_RS00785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC335_RS00795	COG3639	organic phosphonate transmembrane transporter activity
BC335_RS00815	COG0367	asparagine synthase
BC335_RS00830	COG0602	queuosine metabolic process
BC335_RS00835	COG2151	metal-sulfur cluster biosynthetic enzyme
BC335_RS00850	COG2814	Major facilitator Superfamily
BC335_RS00855	COG3590	peptidase
BC335_RS00860	COG3158	transport of potassium into the cell
BC335_RS00905	COG1705	Flagellar rod assembly protein muramidase FlgJ
BC335_RS00905	COG1388	LysM domain
BC335_RS00915	COG0569	domain protein
BC335_RS00915	COG0475	glutathione-regulated potassium exporter activity
BC335_RS00935	COG0588	phosphoglycerate mutase activity
BC335_RS00940	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC335_RS00950	COG1316	TRANSCRIPTIONal
BC335_RS00955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC335_RS00960	COG1368	sulfuric ester hydrolase activity
BC335_RS00970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC335_RS00985	COG3579	cysteine-type endopeptidase activity
BC335_RS00990	COG1418	mRNA catabolic process
BC335_RS00995	COG0516	GMP reductase activity
BC335_RS00995	COG0517	IMP dehydrogenase activity
BC335_RS01000	COG3579	cysteine-type endopeptidase activity
BC335_RS01010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC335_RS01035	COG2131	deaminase
BC335_RS01045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS01050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC335_RS01050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC335_RS01055	COG0084	hydrolase, TatD family'
BC335_RS01065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC335_RS01070	COG4466	Protein conserved in bacteria
BC335_RS01075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC335_RS01080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC335_RS01110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC335_RS01125	COG1078	dGTPase activity
BC335_RS01135	COG3343	RNA polymerase activity
BC335_RS01140	COG0504	CTP synthase activity
BC335_RS01145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC335_RS01155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC335_RS01160	COG4690	dipeptidase activity
BC335_RS01170	COG2233	PERMEase
BC335_RS01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC335_RS01200	COG0519	Catalyzes the synthesis of GMP from XMP
BC335_RS01220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BC335_RS01230	COG0561	phosphatase activity
BC335_RS01235	COG0254	rRNA binding
BC335_RS01240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC335_RS01250	COG0736	holo-[acyl-carrier-protein] synthase activity
BC335_RS01255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC335_RS01270	COG0039	L-malate dehydrogenase activity
BC335_RS01275	COG0193	aminoacyl-tRNA hydrolase activity
BC335_RS01280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC335_RS01285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BC335_RS01300	COG0037	tRNA processing
BC335_RS01310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC335_RS01315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC335_RS01320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BC335_RS01335	COG1956	GAF domain-containing protein
BC335_RS01340	COG0542	response to heat
BC335_RS01345	COG0085	RNA polymerase activity
BC335_RS01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BC335_RS01365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BC335_RS01370	COG0049	tRNA binding
BC335_RS01375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC335_RS01380	COG0051	transcription antitermination factor activity, RNA binding
BC335_RS01385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC335_RS01390	COG0088	Forms part of the polypeptide exit tunnel
BC335_RS01395	COG0089	rRNA binding
BC335_RS01400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC335_RS01405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC335_RS01410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BC335_RS01415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BC335_RS01420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BC335_RS01425	COG0255	Belongs to the universal ribosomal protein uL29 family
BC335_RS01430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC335_RS01435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BC335_RS01440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC335_RS01445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC335_RS01455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC335_RS01460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC335_RS01465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BC335_RS01470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC335_RS01475	COG1841	ribosomal large subunit assembly
BC335_RS01480	COG0200	Binds to the 23S rRNA
BC335_RS01490	COG0563	adenylate kinase activity
BC335_RS01495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC335_RS01505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC335_RS01510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC335_RS01515	COG0202	RNA polymerase activity
BC335_RS01520	COG0203	ribosomal protein L17
BC335_RS01525	COG1122	ATPase activity
BC335_RS01530	COG1122	ATPase activity
BC335_RS01535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC335_RS01540	COG0101	tRNA pseudouridine synthase activity
BC335_RS01545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC335_RS01580	COG1230	cation diffusion facilitator family transporter
BC335_RS01590	COG0588	phosphoglycerate mutase activity
BC335_RS01595	COG2801	Transposase and inactivated derivatives
BC335_RS01610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS01615	COG2801	Transposase and inactivated derivatives
BC335_RS01650	COG0756	dUTP diphosphatase activity
BC335_RS01660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC335_RS01665	COG0215	cysteine-tRNA ligase activity
BC335_RS01670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BC335_RS01675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC335_RS01690	COG1070	Carbohydrate kinase
BC335_RS01700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC335_RS01710	COG0250	Participates in transcription elongation, termination and antitermination
BC335_RS01715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC335_RS01720	COG0081	regulation of translation
BC335_RS01745	COG0573	inorganic phosphate transmembrane transporter activity
BC335_RS01750	COG0581	inorganic phosphate transmembrane transporter activity
BC335_RS01755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC335_RS01760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC335_RS01765	COG0704	Plays a role in the regulation of phosphate uptake
BC335_RS01775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC335_RS01780	COG0222	ribosome binding
BC335_RS01790	COG2813	Specifically methylates the guanine in position
BC335_RS01795	COG0590	tRNA wobble adenosine to inosine editing
BC335_RS01805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BC335_RS01810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC335_RS01815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BC335_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BC335_RS01830	COG3870	Protein conserved in bacteria
BC335_RS01835	COG0470	DNA polymerase III
BC335_RS01855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BC335_RS01860	COG1214	PFAM Peptidase M22, glycoprotease
BC335_RS01865	COG0456	acetyltransferase
BC335_RS01865	COG1214	PFAM Peptidase M22, glycoprotease
BC335_RS01870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC335_RS01885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BC335_RS01895	COG2188	Transcriptional regulator
BC335_RS01910	COG4372	Transposase
BC335_RS01920	COG0488	(ABC) transporter
BC335_RS01925	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BC335_RS01955	COG1621	beta-fructofuranosidase activity
BC335_RS02020	COG0582	viral genome integration into host DNA
BC335_RS02025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BC335_RS02030	COG0459	protein refolding
BC335_RS02035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC335_RS02040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC335_RS02045	COG0632	four-way junction helicase activity
BC335_RS02050	COG2255	four-way junction helicase activity
BC335_RS02060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC335_RS02065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC335_RS02070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BC335_RS02075	COG0513	Belongs to the DEAD box helicase family
BC335_RS02090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC335_RS02095	COG4472	Bacterial protein of unknown function (DUF965)
BC335_RS02100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BC335_RS02105	COG3906	Belongs to the UPF0473 family
BC335_RS02110	COG1193	negative regulation of DNA recombination
BC335_RS02115	COG3118	belongs to the thioredoxin family
BC335_RS02120	COG1970	mechanosensitive ion channel activity
BC335_RS02135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BC335_RS02140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC335_RS02155	COG0668	transmembrane transport
BC335_RS02170	COG0006	proline dipeptidase activity
BC335_RS02180	COG0584	glycerophosphoryl diester phosphodiesterase
BC335_RS02190	COG0737	Belongs to the 5'-nucleotidase family
BC335_RS02200	COG0647	UMP catabolic process
BC335_RS02210	COG2801	Transposase and inactivated derivatives
BC335_RS02215	COG0586	Pfam SNARE associated Golgi protein
BC335_RS02220	COG0492	ferredoxin-NADP+ reductase activity
BC335_RS02390	COG0438	transferase activity, transferring glycosyl groups
BC335_RS02395	COG0438	transferase activity, transferring glycosyl groups
BC335_RS02405	COG1368	sulfuric ester hydrolase activity
BC335_RS02410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC335_RS02415	COG0557	exoribonuclease II activity
BC335_RS02420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BC335_RS02470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC335_RS02475	COG2814	Major facilitator Superfamily
BC335_RS02495	COG2801	Transposase and inactivated derivatives
BC335_RS02500	COG0671	phosphoesterase, PA-phosphatase related
BC335_RS02505	COG0495	leucyl-tRNA aminoacylation
BC335_RS02510	COG2244	polysaccharide biosynthetic process
BC335_RS02565	COG0492	ferredoxin-NADP+ reductase activity
BC335_RS02585	COG1983	PspC domain protein
BC335_RS02595	COG1686	Belongs to the peptidase S11 family
BC335_RS02600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BC335_RS02605	COG1376	ErfK ybiS ycfS ynhG family protein
BC335_RS02615	COG3479	Phenolic acid decarboxylase
BC335_RS02630	COG0018	arginyl-trna synthetase
BC335_RS02660	COG4555	ABC transporter
BC335_RS02700	COG4974	Belongs to the 'phage' integrase family
BC335_RS02745	COG1132	(ABC) transporter
BC335_RS02765	COG4372	Transposase
BC335_RS02795	COG2801	Transposase and inactivated derivatives
BC335_RS02840	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BC335_RS02850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BC335_RS02855	COG1285	pathogenesis
BC335_RS02860	COG2723	6-phospho-beta-galactosidase activity
BC335_RS02875	COG0564	pseudouridine synthase activity
BC335_RS02880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC335_RS02885	COG3679	Belongs to the UPF0342 family
BC335_RS02890	COG0420	3'-5' exonuclease activity
BC335_RS02900	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC335_RS02920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC335_RS02930	COG0537	adenosine 5'-monophosphoramidase activity
BC335_RS02945	COG1131	(ABC) transporter
BC335_RS02955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC335_RS02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC335_RS02965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC335_RS03040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC335_RS03125	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BC335_RS03130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC335_RS03130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC335_RS03135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC335_RS03140	COG0237	dephospho-CoA kinase activity
BC335_RS03145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BC335_RS03155	COG1484	DNA-dependent DNA replication
BC335_RS03160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC335_RS03175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC335_RS03180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BC335_RS03185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC335_RS03190	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BC335_RS03195	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC335_RS03200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC335_RS03205	COG1713	HD superfamily hydrolase involved in NAD metabolism
BC335_RS03210	COG0799	negative regulation of ribosome biogenesis
BC335_RS03215	COG1323	Belongs to the UPF0348 family
BC335_RS03225	COG0745	RESPONSE REGULATOR receiver
BC335_RS03230	COG5002	protein histidine kinase activity
BC335_RS03235	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
BC335_RS03240	COG0706	membrane insertase activity
BC335_RS03245	COG1254	Belongs to the acylphosphatase family
BC335_RS03250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC335_RS03255	COG1733	regulation of RNA biosynthetic process
BC335_RS03260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC335_RS03265	COG0072	phenylalanine-tRNA ligase activity
BC335_RS03290	COG2801	Transposase and inactivated derivatives
BC335_RS03295	COG2971	BadF BadG BcrA BcrD
BC335_RS03305	COG0768	penicillin binding
BC335_RS03310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC335_RS03315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC335_RS03330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC335_RS03335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BC335_RS03365	COG4372	Transposase
BC335_RS03390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC335_RS03395	COG3250	beta-galactosidase activity
BC335_RS03400	COG3250	beta-galactosidase activity
BC335_RS03405	COG1609	Transcriptional regulator
BC335_RS03410	COG2801	Transposase and inactivated derivatives
BC335_RS03420	COG2211	Major facilitator Superfamily
BC335_RS03420	COG2190	(PTS) system
BC335_RS03440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BC335_RS03445	COG0738	Major facilitator superfamily
BC335_RS03455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BC335_RS03460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC335_RS03465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC335_RS03470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC335_RS03475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC335_RS03480	COG0047	phosphoribosylformylglycinamidine synthase activity
BC335_RS03485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC335_RS03495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC335_RS03500	COG0138	bifunctional purine biosynthesis protein purh
BC335_RS03505	COG0151	Belongs to the GarS family
BC335_RS03520	COG1079	Belongs to the binding-protein-dependent transport system permease family
BC335_RS03525	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC335_RS03530	COG3845	ABC transporter
BC335_RS03535	COG1744	ABC transporter substrate-binding protein PnrA-like
BC335_RS03545	COG2814	Major facilitator Superfamily
BC335_RS03550	COG4372	Transposase
BC335_RS03565	COG0737	Belongs to the 5'-nucleotidase family
BC335_RS03600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BC335_RS03605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BC335_RS03610	COG2017	converts alpha-aldose to the beta-anomer
BC335_RS03630	COG0745	RESPONSE REGULATOR receiver
BC335_RS03695	COG2151	metal-sulfur cluster biosynthetic enzyme
BC335_RS03705	COG1760	l-serine dehydratase
BC335_RS03730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BC335_RS03735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC335_RS03745	COG0494	nUDIX hydrolase
BC335_RS03795	COG2801	Transposase and inactivated derivatives
BC335_RS03820	COG0038	chloride channel
BC335_RS03825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS03835	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC335_RS03855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC335_RS03860	COG0284	orotidine-5'-phosphate decarboxylase activity
BC335_RS03865	COG0167	dihydroorotate dehydrogenase activity
BC335_RS03875	COG0540	Belongs to the ATCase OTCase family
BC335_RS03880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC335_RS03885	COG0505	Belongs to the CarA family
BC335_RS03890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC335_RS03910	COG4975	Glucose uptake
BC335_RS03925	COG2936	dipeptidyl-peptidase activity
BC335_RS03965	COG1942	4-Oxalocrotonate Tautomerase
BC335_RS03975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC335_RS03985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC335_RS03990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BC335_RS03995	COG0006	proline dipeptidase activity
BC335_RS04000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC335_RS04005	COG1302	Protein conserved in bacteria
BC335_RS04015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC335_RS04030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC335_RS04035	COG1570	exodeoxyribonuclease VII activity
BC335_RS04040	COG1722	exodeoxyribonuclease VII activity
BC335_RS04050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BC335_RS04055	COG0497	DNA recombination
BC335_RS04065	COG0194	GDP metabolic process
BC335_RS04070	COG1758	RNA polymerase activity
BC335_RS04075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC335_RS04080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC335_RS04085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC335_RS04085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC335_RS04095	COG2815	serine threonine protein kinase
BC335_RS04095	COG0515	serine threonine protein kinase
BC335_RS04100	COG1162	GTPase activity
BC335_RS04105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC335_RS04120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BC335_RS04130	COG1461	Dihydroxyacetone kinase
BC335_RS04135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC335_RS04140	COG0416	fatty acid biosynthetic process
BC335_RS04145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC335_RS04155	COG4608	Belongs to the ABC transporter superfamily
BC335_RS04160	COG0601	transmembrane transport
BC335_RS04180	COG0571	ribonuclease III activity
BC335_RS04185	COG1196	nuclear chromosome segregation
BC335_RS04190	COG0552	protein localization to endoplasmic reticulum
BC335_RS04215	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BC335_RS04220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC335_RS04225	COG0228	four-way junction DNA binding
BC335_RS04230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC335_RS04235	COG0336	Belongs to the RNA methyltransferase TrmD family
BC335_RS04240	COG0335	large ribosomal subunit rRNA binding
BC335_RS04255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BC335_RS04260	COG4224	UPF0291 protein
BC335_RS04265	COG3763	UPF0154 protein
BC335_RS04285	COG1132	(ABC) transporter
BC335_RS04290	COG3590	peptidase
BC335_RS04295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BC335_RS04300	COG0204	Acyl-transferase
BC335_RS04305	COG2827	Endonuclease containing a URI domain
BC335_RS04310	COG0052	Belongs to the universal ribosomal protein uS2 family
BC335_RS04315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BC335_RS04320	COG0528	UMP kinase activity
BC335_RS04325	COG0233	cytoplasmic translational termination
BC335_RS04330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC335_RS04335	COG4589	Belongs to the CDS family
BC335_RS04340	COG0750	zinc metalloprotease
BC335_RS04345	COG0442	prolyl-tRNA aminoacylation
BC335_RS04355	COG0779	Required for maturation of 30S ribosomal subunits
BC335_RS04360	COG0195	Participates in both transcription termination and antitermination
BC335_RS04365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BC335_RS04375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BC335_RS04380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC335_RS04385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC335_RS04390	COG0196	riboflavin kinase activity
BC335_RS04395	COG1420	regulation of RNA biosynthetic process
BC335_RS04400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BC335_RS04405	COG0443	Heat shock 70 kDa protein
BC335_RS04410	COG0484	heat shock protein binding
BC335_RS04425	COG0481	GTPase activity
BC335_RS04430	COG3764	Sortase (surface protein transpeptidase)
BC335_RS04435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BC335_RS04435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC335_RS04440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC335_RS04445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC335_RS04475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS04480	COG0583	DNA-binding transcription factor activity
BC335_RS04525	COG0582	viral genome integration into host DNA
BC335_RS04725	COG3953	SLT domain
BC335_RS04725	COG5412	phage tail tape measure protein
BC335_RS04730	COG1388	LysM domain
BC335_RS04730	COG1705	Flagellar rod assembly protein muramidase FlgJ
BC335_RS04815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC335_RS04825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC335_RS04830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BC335_RS04840	COG1702	phosphate starvation-inducible protein PhoH
BC335_RS04845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BC335_RS04850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC335_RS04855	COG1381	Involved in DNA repair and RecF pathway recombination
BC335_RS04860	COG0752	glycyl-tRNA synthetase alpha subunit
BC335_RS04865	COG0751	glycine-tRNA ligase activity
BC335_RS04870	COG0358	DNA primase activity
BC335_RS04875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC335_RS04885	COG4372	Transposase
BC335_RS04910	COG2384	SAM-dependent methyltransferase
BC335_RS04915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC335_RS04920	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC335_RS04925	COG1725	Transcriptional regulator
BC335_RS04930	COG1131	(ABC) transporter
BC335_RS04990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC335_RS05030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BC335_RS05030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC335_RS05035	COG1304	FMN binding
BC335_RS05050	COG0083	homoserine kinase activity
BC335_RS05055	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BC335_RS05060	COG1074	ATP-dependent DNA helicase activity
BC335_RS05065	COG1199	ATP-dependent helicase activity
BC335_RS05065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC335_RS05075	COG0017	Asparaginyl-tRNA synthetase
BC335_RS05080	COG3935	DnaD domain protein
BC335_RS05085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC335_RS05090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC335_RS05095	COG3331	DNA recombination
BC335_RS05100	COG4474	Belongs to the UPF0398 family
BC335_RS05105	COG3599	regulation of cell shape
BC335_RS05115	COG0116	Belongs to the methyltransferase superfamily
BC335_RS05130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BC335_RS05140	COG0564	pseudouridine synthase activity
BC335_RS05145	COG0505	Belongs to the CarA family
BC335_RS05150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC335_RS05170	COG4974	Belongs to the 'phage' integrase family
BC335_RS05220	COG4372	Transposase
BC335_RS05240	COG1227	inorganic diphosphatase activity
BC335_RS05245	COG0583	DNA-binding transcription factor activity
BC335_RS05255	COG0187	DNA topoisomerase II activity
BC335_RS05260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC335_RS05275	COG0783	Belongs to the Dps family
BC335_RS05355	COG4372	Transposase
BC335_RS05365	COG1126	abc transporter atp-binding protein
BC335_RS05370	COG0765	amino acid transport
BC335_RS05375	COG0765	amino acid transport
BC335_RS05380	COG0789	Transcriptional regulator
BC335_RS05405	COG1051	belongs to the nudix hydrolase family
BC335_RS05410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC335_RS05415	COG0285	dihydrofolate synthase activity
BC335_RS05420	COG0302	gtp cyclohydrolase
BC335_RS05420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC335_RS05435	COG2801	Transposase and inactivated derivatives
BC335_RS05470	COG1733	regulation of RNA biosynthetic process
BC335_RS05475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BC335_RS05490	COG2801	Transposase and inactivated derivatives
BC335_RS05495	COG1114	Component of the transport system for branched-chain amino acids
BC335_RS05525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC335_RS05555	COG2801	Transposase and inactivated derivatives
BC335_RS05560	COG1473	amidohydrolase
BC335_RS05565	COG0531	amino acid
BC335_RS05575	COG3590	peptidase
BC335_RS05580	COG0737	Belongs to the 5'-nucleotidase family
BC335_RS05630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC335_RS05635	COG0732	type I restriction modification DNA specificity domain
BC335_RS05680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC335_RS05710	COG0488	(ABC) transporter
BC335_RS05725	COG2801	Transposase and inactivated derivatives
BC335_RS05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC335_RS05755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC335_RS05760	COG0456	acetyltransferase
BC335_RS05890	COG1132	(ABC) transporter
BC335_RS05905	COG2184	nucleotidyltransferase activity
BC335_RS05915	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC335_RS05940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC335_RS05960	COG0514	ATP-dependent DNA helicase (RecQ)
BC335_RS05970	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BC335_RS06015	COG2274	protein secretion by the type I secretion system
BC335_RS06030	COG2801	Transposase and inactivated derivatives
BC335_RS06055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC335_RS06060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC335_RS06090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC335_RS06105	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BC335_RS06110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC335_RS06115	COG0758	DNA mediated transformation
BC335_RS06120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC335_RS06125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC335_RS06130	COG0025	NhaP-type Na H and K H
BC335_RS06135	COG4479	Belongs to the UPF0346 family
BC335_RS06140	COG1307	EDD domain protein, DegV family
BC335_RS06145	COG1272	protein, Hemolysin III
BC335_RS06150	COG0617	tRNA 3'-terminal CCA addition
BC335_RS06155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC335_RS06165	COG2801	Transposase and inactivated derivatives
BC335_RS06180	COG1160	GTP binding
BC335_RS06185	COG0539	negative regulation of cytoplasmic translation
BC335_RS06190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC335_RS06200	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BC335_RS06205	COG1187	pseudouridine synthase activity
BC335_RS06210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC335_RS06215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC335_RS06220	COG0456	acetyltransferase
BC335_RS06230	COG2996	Protein conserved in bacteria
BC335_RS06240	COG0205	6-phosphofructokinase activity
BC335_RS06245	COG0587	DNA-directed DNA polymerase activity
BC335_RS06255	COG0737	Belongs to the 5'-nucleotidase family
BC335_RS06260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BC335_RS06270	COG0300	oxidoreductase activity
BC335_RS06275	COG1234	tRNA 3'-trailer cleavage
BC335_RS06285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BC335_RS06290	COG0322	excinuclease ABC activity
BC335_RS06330	COG0586	Pfam SNARE associated Golgi protein
BC335_RS06335	COG0531	amino acid
BC335_RS06355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC335_RS06360	COG0436	Aminotransferase
BC335_RS06365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC335_RS06370	COG0124	histidyl-tRNA synthetase
BC335_RS06375	COG1490	D-aminoacyl-tRNA deacylase activity
BC335_RS06380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC335_RS06390	COG2264	protein methyltransferase activity
BC335_RS06395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC335_RS06405	COG1881	PFAM PEBP family protein
BC335_RS06430	COG4720	Psort location CytoplasmicMembrane, score
BC335_RS06435	COG1122	ATPase activity
BC335_RS06445	COG2801	Transposase and inactivated derivatives
BC335_RS06450	COG2707	UPF0756 membrane protein
BC335_RS06475	COG3052	prosthetic group binding
BC335_RS06485	COG2267	carboxylic ester hydrolase activity
BC335_RS06490	COG0471	metal ion transport
BC335_RS06495	COG3579	cysteine-type endopeptidase activity
BC335_RS06520	COG0039	L-malate dehydrogenase activity
BC335_RS06600	COG0114	fumarate hydratase activity
BC335_RS06620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC335_RS06635	COG1523	belongs to the glycosyl hydrolase 13 family
BC335_RS06645	COG2011	ABC-type metal ion transport system permease component
BC335_RS06650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC335_RS06660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS06680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC335_RS06685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BC335_RS06715	COG0148	phosphopyruvate hydratase activity
BC335_RS06745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC335_RS06760	COG2188	Transcriptional regulator
BC335_RS06780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BC335_RS06785	COG1335	isochorismatase
BC335_RS06800	COG4989	oxidoreductase activity
BC335_RS06805	COG1957	nucleoside hydrolase
BC335_RS06830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC335_RS06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC335_RS06840	COG0436	Aminotransferase
BC335_RS06845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC335_RS06850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC335_RS06855	COG1473	amidohydrolase
BC335_RS06860	COG2171	N-acyltransferase activity
BC335_RS06865	COG0019	diaminopimelate decarboxylase activity
BC335_RS06875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC335_RS06895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC335_RS06900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC335_RS06905	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC335_RS06910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC335_RS06925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BC335_RS06930	COG0268	Binds directly to 16S ribosomal RNA
BC335_RS06935	COG1466	dna polymerase III delta subunit
BC335_RS06940	COG0658	competence protein
BC335_RS06940	COG2333	competence protein COMEC
BC335_RS06945	COG1555	photosystem II stabilization
BC335_RS06950	COG3480	Lon protease (S16) C-terminal proteolytic domain
BC335_RS06955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC335_RS06960	COG0742	ribosomal rna small subunit methyltransferase
BC335_RS06970	COG0772	Belongs to the SEDS family
BC335_RS06975	COG1217	gtp-binding protein TYPA
BC335_RS06980	COG0242	peptide deformylase activity
BC335_RS06985	COG5503	Protein of unknown function (DUF1447)
BC335_RS07000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC335_RS07010	COG0406	alpha-ribazole phosphatase activity
BC335_RS07015	COG0482	sulfurtransferase activity
BC335_RS07025	COG1104	cysteine desulfurase activity
BC335_RS07030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC335_RS07040	COG0494	nUDIX hydrolase
BC335_RS07045	COG1278	Cold shock
BC335_RS07050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC335_RS07070	COG1799	cell septum assembly
BC335_RS07075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BC335_RS07085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC335_RS07090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC335_RS07095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BC335_RS07100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC335_RS07115	COG0275	rRNA processing
BC335_RS07120	COG2001	Belongs to the MraZ family
BC335_RS07140	COG1792	Involved in formation and maintenance of cell shape
BC335_RS07145	COG1077	Cell shape determining protein MreB Mrl
BC335_RS07150	COG2003	Belongs to the UPF0758 family
BC335_RS07155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC335_RS07165	COG0525	valine-tRNA ligase activity
BC335_RS07190	COG0463	Glycosyl transferase, family 2
BC335_RS07215	COG1132	(ABC) transporter
BC335_RS07240	COG1187	pseudouridine synthase activity
BC335_RS07275	COG4372	Transposase
BC335_RS07300	COG0301	tRNA thio-modification
BC335_RS07305	COG1104	cysteine desulfurase activity
BC335_RS07310	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BC335_RS07315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC335_RS07335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC335_RS07345	COG0589	response to stress
BC335_RS07350	COG0772	Belongs to the SEDS family
BC335_RS07360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC335_RS07375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC335_RS07380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC335_RS07385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC335_RS07390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC335_RS07395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC335_RS07400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC335_RS07405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC335_RS07410	COG0356	it plays a direct role in the translocation of protons across the membrane
BC335_RS07415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BC335_RS07420	COG0009	L-threonylcarbamoyladenylate synthase
BC335_RS07425	COG2890	protein-(glutamine-N5) methyltransferase activity
BC335_RS07430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BC335_RS07435	COG1435	thymidine kinase activity
BC335_RS07440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC335_RS07455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC335_RS07470	COG0166	Belongs to the GPI family
BC335_RS07480	COG1368	sulfuric ester hydrolase activity
BC335_RS07495	COG5002	protein histidine kinase activity
BC335_RS07495	COG3850	Histidine kinase
BC335_RS07500	COG0745	RESPONSE REGULATOR receiver
BC335_RS07510	COG1482	cell wall glycoprotein biosynthetic process
BC335_RS07515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BC335_RS07525	COG0582	viral genome integration into host DNA
BC335_RS07530	COG1396	sequence-specific DNA binding
BC335_RS07570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BC335_RS07575	COG0827	DNA restriction-modification system
BC335_RS07605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC335_RS07620	COG0217	transcriptional regulatory protein
BC335_RS07655	COG2801	Transposase and inactivated derivatives
BC335_RS07670	COG1263	PTS System
BC335_RS07670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC335_RS07670	COG2190	(PTS) system
BC335_RS07680	COG1929	Belongs to the glycerate kinase type-1 family
BC335_RS07685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC335_RS07695	COG0561	phosphatase activity
BC335_RS07700	COG0561	phosphatase activity
BC335_RS07705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC335_RS07710	COG4856	YbbR-like protein
BC335_RS07725	COG4208	sulfate ABC transporter
BC335_RS07730	COG1176	ABC-type spermidine putrescine transport system, permease component I
BC335_RS07735	COG3842	ATPase activity
BC335_RS07740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC335_RS07750	COG0802	atpase or kinase
BC335_RS07755	COG0280	phosphate acetyltransferase
BC335_RS07760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC335_RS07775	COG0149	triose-phosphate isomerase activity
BC335_RS07780	COG0126	phosphoglycerate kinase activity
BC335_RS07790	COG2390	Transcriptional regulator
BC335_RS07830	COG0740	serine-type endopeptidase activity
BC335_RS07835	COG1481	regulation of sporulation
BC335_RS07840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BC335_RS07845	COG1660	Displays ATPase and GTPase activities
BC335_RS07855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC335_RS07860	COG0556	nucleotide-excision repair
BC335_RS07865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC335_RS07870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BC335_RS07890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BC335_RS07895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BC335_RS07900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BC335_RS07915	COG0653	protein targeting
BC335_RS07930	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BC335_RS07935	COG1739	Uncharacterized protein family UPF0029
BC335_RS07940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC335_RS07945	COG1418	mRNA catabolic process
BC335_RS07950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC335_RS07955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC335_RS07960	COG1426	Protein conserved in bacteria
BC335_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
BC335_RS07970	COG0612	Peptidase, M16
BC335_RS07980	COG1674	ftsk spoiiie
BC335_RS07995	COG0628	permease
BC335_RS08005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC335_RS08010	COG2706	6-phosphogluconolactonase activity
BC335_RS08025	COG0564	pseudouridine synthase activity
BC335_RS08030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC335_RS08035	COG2357	RelA SpoT domain protein
BC335_RS08055	COG4862	establishment of competence for transformation
BC335_RS08060	COG1393	Belongs to the ArsC family
BC335_RS08080	COG0542	response to heat
BC335_RS08100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC335_RS08105	COG1253	flavin adenine dinucleotide binding
BC335_RS08125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC335_RS08175	COG3425	synthase
BC335_RS08185	COG0183	Belongs to the thiolase family
BC335_RS08195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC335_RS08200	COG1295	ribonuclease BN
BC335_RS08205	COG0024	Methionine aminopeptidase
BC335_RS08210	COG0716	FMN binding
BC335_RS08220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC335_RS08235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC335_RS08240	COG0513	Belongs to the DEAD box helicase family
BC335_RS08260	COG1253	flavin adenine dinucleotide binding
BC335_RS08285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BC335_RS08290	COG1349	DNA-binding transcription factor activity
BC335_RS08300	COG2151	metal-sulfur cluster biosynthetic enzyme
BC335_RS08305	COG0719	Fe-S assembly protein
BC335_RS08310	COG0822	iron-sulfur transferase activity
BC335_RS08315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC335_RS08320	COG0719	Fe-S assembly protein
BC335_RS08335	COG0561	phosphatase activity
BC335_RS08360	COG3158	transport of potassium into the cell
BC335_RS08365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BC335_RS08385	COG3830	Belongs to the UPF0237 family
BC335_RS08390	COG2848	UPF0210 protein
BC335_RS08425	COG0765	amino acid transport
BC335_RS08430	COG0765	amino acid transport
BC335_RS08435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC335_RS08455	COG1132	(ABC) transporter
BC335_RS08460	COG1132	(ABC) transporter
BC335_RS08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC335_RS08475	COG0519	Catalyzes the synthesis of GMP from XMP
BC335_RS08475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC335_RS08485	COG0488	(ABC) transporter
BC335_RS08495	COG2814	Major facilitator Superfamily
BC335_RS08500	COG0477	Major facilitator Superfamily
BC335_RS08515	COG2801	Transposase and inactivated derivatives
BC335_RS08525	COG0456	acetyltransferase
BC335_RS08605	COG1278	Cold shock
BC335_RS08620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC335_RS08625	COG1757	Na H antiporter
BC335_RS08635	COG0670	Belongs to the BI1 family
BC335_RS08645	COG1597	lipid kinase activity
BC335_RS08650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC335_RS08655	COG0154	amidase activity
BC335_RS08660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC335_RS08665	COG4851	CamS sex pheromone cAM373 precursor
BC335_RS08670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BC335_RS08680	COG1705	Flagellar rod assembly protein muramidase FlgJ
BC335_RS08690	COG3091	SprT-like family
BC335_RS08705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BC335_RS08730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BC335_RS08740	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BC335_RS08770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BC335_RS08775	COG2188	Transcriptional regulator
BC335_RS08825	COG0588	phosphoglycerate mutase activity
BC335_RS08870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC335_RS08875	COG2188	Transcriptional regulator
BC335_RS08945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BC335_RS08975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC335_RS08980	COG1454	alcohol dehydrogenase
BC335_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
BC335_RS08985	COG1113	amino acid transport
BC335_RS08995	COG0583	DNA-binding transcription factor activity
BC335_RS09005	COG3716	PTS system mannose fructose sorbose family IID component
BC335_RS09010	COG3715	PTS system
BC335_RS09035	COG2207	Transcriptional regulator
BC335_RS09070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC335_RS09075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC335_RS09080	COG0398	Pfam SNARE associated Golgi protein
BC335_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
BC335_RS09110	COG2409	Drug exporters of the RND superfamily
BC335_RS09110	COG1033	growth of symbiont in host cell
BC335_RS09120	COG2801	Transposase and inactivated derivatives
BC335_RS09160	COG1175	transmembrane transport
BC335_RS09215	COG1132	(ABC) transporter
BC335_RS09220	COG2267	carboxylic ester hydrolase activity
BC335_RS09225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BC335_RS09245	COG1653	transport
BC335_RS09250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC335_RS09290	COG3973	AAA domain
BC335_RS09300	COG0588	phosphoglycerate mutase activity
BC335_RS09310	COG1136	(ABC) transporter
BC335_RS09335	COG0252	asparaginase activity
BC335_RS09375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC335_RS09385	COG0531	amino acid
BC335_RS09435	COG1216	Glycosyl transferase, family 2
BC335_RS09440	COG0438	transferase activity, transferring glycosyl groups
BC335_RS09455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC335_RS09460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC335_RS09465	COG4464	protein tyrosine phosphatase activity
BC335_RS09470	COG0489	protein tyrosine kinase activity
BC335_RS09480	COG1316	TRANSCRIPTIONal
BC335_RS09495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC335_RS09515	COG2801	Transposase and inactivated derivatives
BC335_RS09520	COG0791	NLP P60 protein
BC335_RS09595	COG0488	(ABC) transporter
BC335_RS09615	COG1316	TRANSCRIPTIONal
BC335_RS09620	COG1164	Oligoendopeptidase f
BC335_RS09645	COG2801	Transposase and inactivated derivatives
BC335_RS09650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC335_RS09655	COG1121	(ABC) transporter
BC335_RS09670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC335_RS09670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC335_RS09670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC335_RS09685	COG1105	Belongs to the carbohydrate kinase PfkB family
BC335_RS09690	COG1349	DNA-binding transcription factor activity
BC335_RS09720	COG3655	Transcriptional regulator
BC335_RS09740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC335_RS09755	COG1132	(ABC) transporter
BC335_RS09770	COG0012	GTP binding
BC335_RS09775	COG4481	Protein conserved in bacteria
BC335_RS09780	COG1475	DNA binding
BC335_RS09785	COG1192	Involved in chromosome partitioning
BC335_RS09795	COG0357	Ribosomal RNA small subunit methyltransferase G
BC335_RS09825	COG0431	NADPH-dependent FMN reductase
BC335_RS09830	COG0431	NADPH-dependent FMN reductase
BC335_RS09860	COG1136	(ABC) transporter
BC335_RS09865	COG0577	efflux transmembrane transporter activity
BC335_RS09875	COG0406	alpha-ribazole phosphatase activity
BC335_RS09885	COG3022	response to hydroperoxide
BC335_RS09895	COG3104	oligopeptide transport
BC335_RS09910	COG0308	aminopeptidase N
BC335_RS09975	COG1045	serine acetyltransferase
BC335_RS09980	COG0626	cystathionine gamma-synthase activity
BC335_RS09985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC335_RS10040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC335_RS10045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BC335_RS10060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC335_RS10075	COG1268	BioY protein
BC335_RS10085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BC335_RS10090	COG0825	malonyl-CoA metabolic process
BC335_RS10095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BC335_RS10100	COG0439	Biotin carboxylase
BC335_RS10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC335_RS10110	COG0511	ligase activity, forming carbon-carbon bonds
BC335_RS10115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC335_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
BC335_RS10125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BC335_RS10130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC335_RS10135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC335_RS10145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC335_RS10155	COG2261	transglycosylase associated protein
BC335_RS10160	COG2801	Transposase and inactivated derivatives
BC335_RS10175	COG4975	Glucose uptake
BC335_RS10195	COG2217	Heavy metal translocating P-type atpase
BC335_RS10205	COG1247	-acetyltransferase
BC335_RS10285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC335_RS10325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC335_RS10335	COG1397	ADP-ribosylglycohydrolase
BC335_RS10350	COG2223	nitrite transmembrane transporter activity
BC335_RS10405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC335_RS10425	COG2365	Tyrosine phosphatase family
BC335_RS10435	COG0351	phosphomethylpyrimidine kinase
BC335_RS10445	COG3442	glutamine amidotransferase
BC335_RS10485	COG0488	(ABC) transporter
BC335_RS10500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC335_RS10505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BC335_RS10510	COG0516	GMP reductase activity
BC335_RS10530	COG2502	aspartate--ammonia ligase
BC335_RS10550	COG1113	amino acid transport
BC335_RS10555	COG1113	amino acid transport
BC335_RS10565	COG0681	Belongs to the peptidase S26 family
BC335_RS10570	COG0542	response to heat
BC335_RS10585	COG1136	(ABC) transporter
BC335_RS10665	COG0656	L-ascorbic acid biosynthetic process
BC335_RS10680	COG2244	polysaccharide biosynthetic process
BC335_RS10720	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BC335_RS10725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC335_RS10730	COG1696	Membrane protein involved in D-alanine export
BC335_RS10735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC335_RS10775	COG2217	Heavy metal translocating P-type atpase
BC335_RS10790	COG2161	toxin-antitoxin pair type II binding
BC335_RS10795	COG4115	mRNA cleavage
BC335_RS10800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BC335_RS10845	COG0656	L-ascorbic acid biosynthetic process
BC335_RS10850	COG0363	glucosamine-6-phosphate deaminase activity
BC335_RS10870	COG1737	Transcriptional regulator
BC335_RS10875	COG1428	Deoxynucleoside kinase
BC335_RS10880	COG1428	Deoxynucleoside kinase
BC335_RS10895	COG0561	phosphatase activity
BC335_RS10900	COG2252	PERMEase
BC335_RS10925	COG2252	PERMEase
BC335_RS10935	COG0004	ammonium transporteR
BC335_RS10945	COG2252	PERMEase
BC335_RS10970	COG2217	Heavy metal translocating P-type atpase
BC335_RS10995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC335_RS11000	COG0445	tRNA wobble uridine modification
BC335_RS11005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC335_RS11010	COG0706	membrane insertase activity
BC335_RS11015	COG0594	ribonuclease P activity
BC335_RS11020	COG0230	Belongs to the bacterial ribosomal protein bL34 family