locus-tag	class	description
H0I41_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0I41_RS00010	COG0592	DNA-directed DNA polymerase activity
H0I41_RS00015	COG2501	S4 domain
H0I41_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0I41_RS00025	COG0187	DNA topoisomerase II activity
H0I41_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0I41_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
H0I41_RS00040	COG0629	single-stranded DNA binding
H0I41_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0I41_RS00060	COG0359	binds to the 23S rRNA
H0I41_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
H0I41_RS00070	COG1940	carbohydrate kinase activity
H0I41_RS00095	COG0640	Transcriptional regulator
H0I41_RS00135	COG0531	amino acid
H0I41_RS00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0I41_RS00185	COG1011	Hydrolase
H0I41_RS00190	COG1307	EDD domain protein, DegV family
H0I41_RS00220	COG3590	peptidase
H0I41_RS00245	COG2261	transglycosylase associated protein
H0I41_RS00250	COG0708	Exodeoxyribonuclease III
H0I41_RS00280	COG0628	permease
H0I41_RS00290	COG0517	IMP dehydrogenase activity
H0I41_RS00290	COG0516	GMP reductase activity
H0I41_RS00300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0I41_RS00320	COG0531	amino acid
H0I41_RS00330	COG3976	FMN-binding domain protein
H0I41_RS00330	COG1053	succinate dehydrogenase
H0I41_RS00335	COG1114	Component of the transport system for branched-chain amino acids
H0I41_RS00340	COG2226	methyltransferase
H0I41_RS00345	COG2267	carboxylic ester hydrolase activity
H0I41_RS00375	COG1442	glycosyl transferase family 8
H0I41_RS00410	COG0745	RESPONSE REGULATOR receiver
H0I41_RS00415	COG5002	protein histidine kinase activity
H0I41_RS00430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H0I41_RS00435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0I41_RS00440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0I41_RS00450	COG1122	ATPase activity
H0I41_RS00465	COG0501	Belongs to the peptidase M48B family
H0I41_RS00470	COG1704	LemA family
H0I41_RS00475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H0I41_RS00500	COG1215	transferase activity, transferring glycosyl groups
H0I41_RS00505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H0I41_RS00525	COG1126	abc transporter atp-binding protein
H0I41_RS00530	COG0765	amino acid transport
H0I41_RS00535	COG2094	Belongs to the DNA glycosylase MPG family
H0I41_RS00540	COG3189	MarR family transcriptional regulator
H0I41_RS00545	COG0861	Integral membrane protein TerC family
H0I41_RS00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0I41_RS00555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0I41_RS00565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0I41_RS00570	COG2738	Putative neutral zinc metallopeptidase
H0I41_RS00580	COG0328	RNA-DNA hybrid ribonuclease activity
H0I41_RS00595	COG1216	Glycosyl transferase, family 2
H0I41_RS00600	COG2267	carboxylic ester hydrolase activity
H0I41_RS00610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0I41_RS00615	COG1113	amino acid transport
H0I41_RS00635	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0I41_RS00670	COG2188	Transcriptional regulator
H0I41_RS00675	COG2222	sugar isomerase
H0I41_RS00685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS00695	COG3716	PTS system mannose fructose sorbose family IID component
H0I41_RS00700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS00700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I41_RS00710	COG3613	nucleoside 2-deoxyribosyltransferase
H0I41_RS00725	COG2365	Tyrosine phosphatase family
H0I41_RS00730	COG0589	response to stress
H0I41_RS00755	COG3639	organic phosphonate transmembrane transporter activity
H0I41_RS00770	COG0367	asparagine synthase
H0I41_RS00780	COG1328	CTP reductase activity
H0I41_RS00785	COG0602	queuosine metabolic process
H0I41_RS00790	COG2151	metal-sulfur cluster biosynthetic enzyme
H0I41_RS00800	COG2814	Major facilitator Superfamily
H0I41_RS00805	COG3684	Belongs to the aldolase LacD family
H0I41_RS00825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0I41_RS00825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0I41_RS00825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I41_RS00830	COG3590	peptidase
H0I41_RS00840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0I41_RS00845	COG3158	transport of potassium into the cell
H0I41_RS00850	COG3158	transport of potassium into the cell
H0I41_RS00875	COG1705	Flagellar rod assembly protein muramidase FlgJ
H0I41_RS00875	COG1388	LysM domain
H0I41_RS00890	COG0475	glutathione-regulated potassium exporter activity
H0I41_RS00890	COG0569	domain protein
H0I41_RS00895	COG0673	inositol 2-dehydrogenase activity
H0I41_RS00915	COG0588	phosphoglycerate mutase activity
H0I41_RS00920	COG1598	PFAM Uncharacterised protein family UPF0150
H0I41_RS00925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0I41_RS00945	COG4975	Glucose uptake
H0I41_RS00955	COG1316	TRANSCRIPTIONal
H0I41_RS00960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H0I41_RS00965	COG1368	sulfuric ester hydrolase activity
H0I41_RS00970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0I41_RS00980	COG3579	cysteine-type endopeptidase activity
H0I41_RS00990	COG0601	transmembrane transport
H0I41_RS00995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0I41_RS01005	COG4608	Belongs to the ABC transporter superfamily
H0I41_RS01010	COG1418	mRNA catabolic process
H0I41_RS01025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0I41_RS01035	COG2723	6-phospho-beta-galactosidase activity
H0I41_RS01045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS01050	COG2188	Transcriptional regulator
H0I41_RS01060	COG2723	6-phospho-beta-galactosidase activity
H0I41_RS01065	COG2188	Transcriptional regulator
H0I41_RS01070	COG1447	Phosphotransferase system cellobiose-specific component IIA
H0I41_RS01080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS01090	COG2723	6-phospho-beta-galactosidase activity
H0I41_RS01120	COG2131	deaminase
H0I41_RS01130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0I41_RS01135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I41_RS01135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I41_RS01140	COG0084	hydrolase, TatD family'
H0I41_RS01150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0I41_RS01155	COG4466	Protein conserved in bacteria
H0I41_RS01160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0I41_RS01165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0I41_RS01170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0I41_RS01175	COG1609	Transcriptional regulator
H0I41_RS01180	COG0366	Alpha amylase catalytic
H0I41_RS01195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I41_RS01200	COG3842	ATPase activity
H0I41_RS01205	COG1653	transport
H0I41_RS01210	COG1175	transmembrane transport
H0I41_RS01215	COG3833	ABC-type maltose transport systems, permease component
H0I41_RS01220	COG0366	Alpha amylase catalytic
H0I41_RS01225	COG1078	dGTPase activity
H0I41_RS01235	COG3343	RNA polymerase activity
H0I41_RS01240	COG0504	CTP synthase activity
H0I41_RS01245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0I41_RS01250	COG2233	PERMEase
H0I41_RS01255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0I41_RS01265	COG0519	Catalyzes the synthesis of GMP from XMP
H0I41_RS01270	COG1733	regulation of RNA biosynthetic process
H0I41_RS01290	COG1881	PFAM PEBP family protein
H0I41_RS01300	COG1396	sequence-specific DNA binding
H0I41_RS01305	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0I41_RS01365	COG0456	acetyltransferase
H0I41_RS01380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0I41_RS01385	COG0028	Belongs to the TPP enzyme family
H0I41_RS01390	COG0679	Auxin Efflux Carrier
H0I41_RS01410	COG1733	regulation of RNA biosynthetic process
H0I41_RS01420	COG0778	Nitroreductase
H0I41_RS01425	COG4690	dipeptidase activity
H0I41_RS01430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0I41_RS01440	COG4120	Belongs to the binding-protein-dependent transport system permease family
H0I41_RS01450	COG0531	amino acid
H0I41_RS01455	COG0254	rRNA binding
H0I41_RS01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0I41_RS01470	COG0736	holo-[acyl-carrier-protein] synthase activity
H0I41_RS01485	COG0039	L-malate dehydrogenase activity
H0I41_RS01490	COG0193	aminoacyl-tRNA hydrolase activity
H0I41_RS01495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0I41_RS01500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0I41_RS01510	COG1185	polyribonucleotide nucleotidyltransferase activity
H0I41_RS01515	COG0037	tRNA processing
H0I41_RS01535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0I41_RS01540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0I41_RS01545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0I41_RS01560	COG0542	response to heat
H0I41_RS01565	COG0085	RNA polymerase activity
H0I41_RS01570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0I41_RS01585	COG0049	tRNA binding
H0I41_RS01590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0I41_RS01600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0I41_RS01605	COG0088	Forms part of the polypeptide exit tunnel
H0I41_RS01610	COG0089	rRNA binding
H0I41_RS01615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0I41_RS01630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0I41_RS01635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0I41_RS01640	COG0255	Belongs to the universal ribosomal protein uL29 family
H0I41_RS01655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0I41_RS01660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0I41_RS01670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0I41_RS01675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0I41_RS01680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0I41_RS01695	COG0200	Binds to the 23S rRNA
H0I41_RS01705	COG0563	adenylate kinase activity
H0I41_RS01710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0I41_RS01730	COG0202	RNA polymerase activity
H0I41_RS01735	COG0203	ribosomal protein L17
H0I41_RS01740	COG1122	ATPase activity
H0I41_RS01745	COG1122	ATPase activity
H0I41_RS01750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H0I41_RS01755	COG0101	tRNA pseudouridine synthase activity
H0I41_RS01760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0I41_RS01775	COG1132	(ABC) transporter
H0I41_RS01820	COG0588	phosphoglycerate mutase activity
H0I41_RS01840	COG0531	amino acid
H0I41_RS01845	COG0201	protein transport
H0I41_RS01855	COG1073	alpha beta
H0I41_RS01865	COG0653	protein targeting
H0I41_RS01890	COG1442	glycosyl transferase family 8
H0I41_RS01890	COG1216	Glycosyl transferase, family 2
H0I41_RS01895	COG0438	transferase activity, transferring glycosyl groups
H0I41_RS01905	COG1316	TRANSCRIPTIONal
H0I41_RS01910	COG0756	dUTP diphosphatase activity
H0I41_RS01920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0I41_RS01925	COG0215	cysteine-tRNA ligase activity
H0I41_RS01930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H0I41_RS01935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I41_RS01950	COG1070	Carbohydrate kinase
H0I41_RS01955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0I41_RS01965	COG0142	geranyltranstransferase activity
H0I41_RS01980	COG0250	Participates in transcription elongation, termination and antitermination
H0I41_RS01985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0I41_RS01990	COG0081	regulation of translation
H0I41_RS01995	COG0765	amino acid transport
H0I41_RS02000	COG1126	abc transporter atp-binding protein
H0I41_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0I41_RS02010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0I41_RS02030	COG2813	Specifically methylates the guanine in position
H0I41_RS02050	COG0590	tRNA wobble adenosine to inosine editing
H0I41_RS02060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0I41_RS02065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0I41_RS02080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0I41_RS02085	COG3870	Protein conserved in bacteria
H0I41_RS02095	COG4467	Involved in initiation control of chromosome replication
H0I41_RS02110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H0I41_RS02115	COG1214	PFAM Peptidase M22, glycoprotease
H0I41_RS02125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0I41_RS02150	COG0516	GMP reductase activity
H0I41_RS02155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0I41_RS02160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0I41_RS02170	COG0494	nUDIX hydrolase
H0I41_RS02215	COG1653	transport
H0I41_RS02220	COG0488	(ABC) transporter
H0I41_RS02265	COG0459	protein refolding
H0I41_RS02295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I41_RS02300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0I41_RS02305	COG0632	four-way junction helicase activity
H0I41_RS02310	COG2255	four-way junction helicase activity
H0I41_RS02315	COG1862	Preprotein translocase
H0I41_RS02320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H0I41_RS02325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0I41_RS02330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I41_RS02335	COG0513	Belongs to the DEAD box helicase family
H0I41_RS02340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0I41_RS02350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0I41_RS02355	COG3906	Belongs to the UPF0473 family
H0I41_RS02365	COG1193	negative regulation of DNA recombination
H0I41_RS02370	COG3118	belongs to the thioredoxin family
H0I41_RS02375	COG1719	4-vinyl reductase, 4VR
H0I41_RS02380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0I41_RS02385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0I41_RS02395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0I41_RS02400	COG0668	transmembrane transport
H0I41_RS02415	COG0006	proline dipeptidase activity
H0I41_RS02435	COG0584	glycerophosphoryl diester phosphodiesterase
H0I41_RS02445	COG0737	Belongs to the 5'-nucleotidase family
H0I41_RS02455	COG0647	UMP catabolic process
H0I41_RS02465	COG0586	Pfam SNARE associated Golgi protein
H0I41_RS02470	COG0492	ferredoxin-NADP+ reductase activity
H0I41_RS02475	COG1098	S1 RNA binding domain
H0I41_RS02515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0I41_RS02520	COG0477	Major facilitator Superfamily
H0I41_RS02535	COG0495	leucyl-tRNA aminoacylation
H0I41_RS02540	COG2244	polysaccharide biosynthetic process
H0I41_RS02555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0I41_RS02560	COG1686	Belongs to the peptidase S11 family
H0I41_RS02565	COG0018	arginyl-trna synthetase
H0I41_RS02580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H0I41_RS02580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H0I41_RS02595	COG3715	PTS system
H0I41_RS02600	COG3716	PTS system mannose fructose sorbose family IID component
H0I41_RS02605	COG1285	pathogenesis
H0I41_RS02610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0I41_RS02630	COG1956	GAF domain-containing protein
H0I41_RS02645	COG0519	Catalyzes the synthesis of GMP from XMP
H0I41_RS02660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0I41_RS02665	COG2814	Major facilitator Superfamily
H0I41_RS02670	COG2814	Major facilitator Superfamily
H0I41_RS02685	COG0456	acetyltransferase
H0I41_RS02695	COG0561	phosphatase activity
H0I41_RS02705	COG0561	phosphatase activity
H0I41_RS02710	COG4977	sequence-specific DNA binding
H0I41_RS02720	COG1349	DNA-binding transcription factor activity
H0I41_RS02725	COG0698	ribose 5-phosphate isomerase
H0I41_RS02730	COG0698	ribose 5-phosphate isomerase
H0I41_RS02740	COG1447	Phosphotransferase system cellobiose-specific component IIA
H0I41_RS02745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS02745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS02775	COG0531	amino acid
H0I41_RS02785	COG3579	cysteine-type endopeptidase activity
H0I41_RS02790	COG0531	amino acid
H0I41_RS02810	COG2814	Major facilitator Superfamily
H0I41_RS02840	COG4619	ABC transporter
H0I41_RS02845	COG0390	transport system, permease component
H0I41_RS02865	COG3104	oligopeptide transport
H0I41_RS02875	COG2814	Major facilitator Superfamily
H0I41_RS02890	COG1132	(ABC) transporter
H0I41_RS02895	COG1132	(ABC) transporter
H0I41_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0I41_RS02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0I41_RS02915	COG0765	amino acid transport
H0I41_RS02920	COG0765	amino acid transport
H0I41_RS02930	COG0366	Alpha amylase catalytic
H0I41_RS02935	COG2188	Transcriptional regulator
H0I41_RS02940	COG2190	(PTS) system
H0I41_RS02940	COG1263	PTS System
H0I41_RS02940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS02955	COG0572	uridine kinase
H0I41_RS02985	COG2274	protein secretion by the type I secretion system
H0I41_RS03060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0I41_RS03070	COG0765	amino acid transport
H0I41_RS03075	COG1126	abc transporter atp-binding protein
H0I41_RS03090	COG0573	inorganic phosphate transmembrane transporter activity
H0I41_RS03095	COG0581	inorganic phosphate transmembrane transporter activity
H0I41_RS03100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0I41_RS03105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0I41_RS03110	COG0704	Plays a role in the regulation of phosphate uptake
H0I41_RS03115	COG1288	antiporter activity
H0I41_RS03120	COG0783	Belongs to the Dps family
H0I41_RS03130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0I41_RS03140	COG2188	Transcriptional regulator
H0I41_RS03170	COG1253	flavin adenine dinucleotide binding
H0I41_RS03180	COG0531	amino acid
H0I41_RS03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS03205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0I41_RS03215	COG0716	FMN binding
H0I41_RS03220	COG0024	Methionine aminopeptidase
H0I41_RS03230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0I41_RS03235	COG0517	IMP dehydrogenase activity
H0I41_RS03235	COG1125	glycine betaine transport
H0I41_RS03255	COG2357	RelA SpoT domain protein
H0I41_RS03260	COG0745	RESPONSE REGULATOR receiver
H0I41_RS03265	COG5002	protein histidine kinase activity
H0I41_RS03270	COG2936	dipeptidyl-peptidase activity
H0I41_RS03275	COG0308	aminopeptidase N
H0I41_RS03280	COG0561	phosphatase activity
H0I41_RS03290	COG1132	(ABC) transporter
H0I41_RS03295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0I41_RS03320	COG2814	Major facilitator Superfamily
H0I41_RS03330	COG4166	transmembrane transport
H0I41_RS03340	COG3579	cysteine-type endopeptidase activity
H0I41_RS03400	COG1942	4-Oxalocrotonate Tautomerase
H0I41_RS03420	COG1393	Belongs to the ArsC family
H0I41_RS03425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0I41_RS03430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0I41_RS03435	COG0006	proline dipeptidase activity
H0I41_RS03440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0I41_RS03450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I41_RS03455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0I41_RS03460	COG1570	exodeoxyribonuclease VII activity
H0I41_RS03465	COG1722	exodeoxyribonuclease VII activity
H0I41_RS03475	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H0I41_RS03480	COG0497	DNA recombination
H0I41_RS03490	COG0194	GDP metabolic process
H0I41_RS03495	COG1758	RNA polymerase activity
H0I41_RS03500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0I41_RS03505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0I41_RS03510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0I41_RS03510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I41_RS03515	COG0631	protein serine/threonine phosphatase activity
H0I41_RS03520	COG2815	serine threonine protein kinase
H0I41_RS03520	COG0515	serine threonine protein kinase
H0I41_RS03525	COG1162	GTPase activity
H0I41_RS03530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0I41_RS03535	COG1564	THIamine pyrophosphokinase
H0I41_RS03540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0I41_RS03550	COG1461	Dihydroxyacetone kinase
H0I41_RS03555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0I41_RS03560	COG0416	fatty acid biosynthetic process
H0I41_RS03565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I41_RS03575	COG4608	Belongs to the ABC transporter superfamily
H0I41_RS03580	COG0601	transmembrane transport
H0I41_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0I41_RS03600	COG0571	ribonuclease III activity
H0I41_RS03605	COG1196	nuclear chromosome segregation
H0I41_RS03610	COG0552	protein localization to endoplasmic reticulum
H0I41_RS03620	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H0I41_RS03625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0I41_RS03630	COG0228	four-way junction DNA binding
H0I41_RS03635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0I41_RS03640	COG0336	Belongs to the RNA methyltransferase TrmD family
H0I41_RS03655	COG0494	nUDIX hydrolase
H0I41_RS03665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0I41_RS03670	COG4224	UPF0291 protein
H0I41_RS03675	COG3763	UPF0154 protein
H0I41_RS03680	COG1132	(ABC) transporter
H0I41_RS03685	COG1132	(ABC) transporter
H0I41_RS03690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0I41_RS03695	COG0204	Acyl-transferase
H0I41_RS03700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H0I41_RS03705	COG0052	Belongs to the universal ribosomal protein uS2 family
H0I41_RS03710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0I41_RS03715	COG0528	UMP kinase activity
H0I41_RS03720	COG0233	cytoplasmic translational termination
H0I41_RS03725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0I41_RS03730	COG4589	Belongs to the CDS family
H0I41_RS03735	COG0750	zinc metalloprotease
H0I41_RS03740	COG0442	prolyl-tRNA aminoacylation
H0I41_RS03750	COG0779	Required for maturation of 30S ribosomal subunits
H0I41_RS03755	COG0195	Participates in both transcription termination and antitermination
H0I41_RS03760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H0I41_RS03770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0I41_RS03775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0I41_RS03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0I41_RS03785	COG0196	riboflavin kinase activity
H0I41_RS03790	COG0488	(ABC) transporter
H0I41_RS03800	COG1420	regulation of RNA biosynthetic process
H0I41_RS03805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0I41_RS03810	COG0443	Heat shock 70 kDa protein
H0I41_RS03815	COG0484	heat shock protein binding
H0I41_RS03820	COG0481	GTPase activity
H0I41_RS03825	COG3764	Sortase (surface protein transpeptidase)
H0I41_RS03830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H0I41_RS03830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0I41_RS03835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0I41_RS03845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0I41_RS03850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0I41_RS03855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0I41_RS03865	COG2217	Heavy metal translocating P-type atpase
H0I41_RS03870	COG0583	DNA-binding transcription factor activity
H0I41_RS03885	COG0148	phosphopyruvate hydratase activity
H0I41_RS03895	COG0488	(ABC) transporter
H0I41_RS03900	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H0I41_RS03925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0I41_RS03930	COG2011	ABC-type metal ion transport system permease component
H0I41_RS03935	COG0114	fumarate hydratase activity
H0I41_RS03940	COG1053	succinate dehydrogenase
H0I41_RS03945	COG0039	L-malate dehydrogenase activity
H0I41_RS03955	COG0252	asparaginase activity
H0I41_RS03960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0I41_RS03970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0I41_RS03975	COG2264	protein methyltransferase activity
H0I41_RS03985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0I41_RS03990	COG1490	D-aminoacyl-tRNA deacylase activity
H0I41_RS03995	COG0124	histidyl-tRNA synthetase
H0I41_RS04000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0I41_RS04005	COG0436	Aminotransferase
H0I41_RS04010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I41_RS04025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I41_RS04030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H0I41_RS04035	COG1760	l-serine dehydratase
H0I41_RS04040	COG1760	l-serine dehydratase
H0I41_RS04045	COG2151	metal-sulfur cluster biosynthetic enzyme
H0I41_RS04050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H0I41_RS04055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0I41_RS04060	COG1610	YqeY-like protein
H0I41_RS04065	COG1702	phosphate starvation-inducible protein PhoH
H0I41_RS04070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0I41_RS04075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0I41_RS04080	COG1381	Involved in DNA repair and RecF pathway recombination
H0I41_RS04085	COG0752	glycyl-tRNA synthetase alpha subunit
H0I41_RS04090	COG0751	glycine-tRNA ligase activity
H0I41_RS04095	COG0305	Participates in initiation and elongation during chromosome replication
H0I41_RS04095	COG0358	DNA primase activity
H0I41_RS04100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0I41_RS04140	COG0765	amino acid transport
H0I41_RS04145	COG0765	amino acid transport
H0I41_RS04150	COG1126	abc transporter atp-binding protein
H0I41_RS04160	COG2384	SAM-dependent methyltransferase
H0I41_RS04165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0I41_RS04170	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I41_RS04175	COG1725	Transcriptional regulator
H0I41_RS04180	COG1131	(ABC) transporter
H0I41_RS04210	COG1132	(ABC) transporter
H0I41_RS04250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0I41_RS04250	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H0I41_RS04255	COG0393	Putative heavy-metal-binding
H0I41_RS04260	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H0I41_RS04275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0I41_RS04280	COG0284	orotidine-5'-phosphate decarboxylase activity
H0I41_RS04285	COG0167	dihydroorotate dehydrogenase activity
H0I41_RS04295	COG0540	Belongs to the ATCase OTCase family
H0I41_RS04300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0I41_RS04305	COG0505	Belongs to the CarA family
H0I41_RS04310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0I41_RS04320	COG1335	isochorismatase
H0I41_RS04325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H0I41_RS04350	COG3590	peptidase
H0I41_RS04355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0I41_RS04360	COG3958	Transketolase
H0I41_RS04365	COG3959	Transketolase, thiamine diphosphate binding domain
H0I41_RS04370	COG1609	Transcriptional regulator
H0I41_RS04385	COG3711	transcriptional antiterminator
H0I41_RS04390	COG2190	(PTS) system
H0I41_RS04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS04390	COG1263	PTS System
H0I41_RS04395	COG1609	Transcriptional regulator
H0I41_RS04410	COG0778	Nitroreductase
H0I41_RS04415	COG1902	pentaerythritol trinitrate reductase activity
H0I41_RS04430	COG1929	Belongs to the glycerate kinase type-1 family
H0I41_RS04445	COG2274	protein secretion by the type I secretion system
H0I41_RS04450	COG1132	(ABC) transporter
H0I41_RS04455	COG0148	phosphopyruvate hydratase activity
H0I41_RS04510	COG2365	Tyrosine phosphatase family
H0I41_RS04535	COG0456	acetyltransferase
H0I41_RS04585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0I41_RS04590	COG1869	D-ribose catabolic process
H0I41_RS04595	COG4975	Glucose uptake
H0I41_RS04610	COG4988	ABC transporter
H0I41_RS04615	COG1132	(ABC) transporter
H0I41_RS04640	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H0I41_RS04645	COG1074	ATP-dependent DNA helicase activity
H0I41_RS04650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0I41_RS04650	COG1199	ATP-dependent helicase activity
H0I41_RS04660	COG0017	Asparaginyl-tRNA synthetase
H0I41_RS04665	COG3935	DnaD domain protein
H0I41_RS04670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0I41_RS04680	COG3331	DNA recombination
H0I41_RS04685	COG4474	Belongs to the UPF0398 family
H0I41_RS04690	COG3599	regulation of cell shape
H0I41_RS04700	COG0116	Belongs to the methyltransferase superfamily
H0I41_RS04715	COG1307	EDD domain protein, DegV family
H0I41_RS04725	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H0I41_RS04730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0I41_RS04735	COG0564	pseudouridine synthase activity
H0I41_RS04760	COG1307	EDD domain protein, DegV family
H0I41_RS04770	COG0583	DNA-binding transcription factor activity
H0I41_RS04775	COG4974	Belongs to the 'phage' integrase family
H0I41_RS04790	COG0514	ATP-dependent DNA helicase (RecQ)
H0I41_RS04795	COG1227	inorganic diphosphatase activity
H0I41_RS04800	COG0583	DNA-binding transcription factor activity
H0I41_RS04805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0I41_RS04810	COG0187	DNA topoisomerase II activity
H0I41_RS04815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H0I41_RS04820	COG0110	maltose O-acetyltransferase activity
H0I41_RS04845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0I41_RS04855	COG0656	L-ascorbic acid biosynthetic process
H0I41_RS04860	COG1132	(ABC) transporter
H0I41_RS04870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0I41_RS04880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H0I41_RS04900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I41_RS04915	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H0I41_RS04935	COG1914	H( )-stimulated, divalent metal cation uptake system
H0I41_RS04945	COG0719	Fe-S assembly protein
H0I41_RS04955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0I41_RS04960	COG0719	Fe-S assembly protein
H0I41_RS04965	COG0396	ATPase activity
H0I41_RS04970	COG1114	Component of the transport system for branched-chain amino acids
H0I41_RS04990	COG5002	protein histidine kinase activity
H0I41_RS04995	COG0745	RESPONSE REGULATOR receiver
H0I41_RS05000	COG1051	belongs to the nudix hydrolase family
H0I41_RS05005	COG1011	Hydrolase
H0I41_RS05035	COG3527	Alpha-acetolactate decarboxylase
H0I41_RS05040	COG0028	Belongs to the TPP enzyme family
H0I41_RS05055	COG2855	membrane
H0I41_RS05080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H0I41_RS05095	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H0I41_RS05100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0I41_RS05105	COG0758	DNA mediated transformation
H0I41_RS05110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0I41_RS05115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H0I41_RS05120	COG3409	Peptidoglycan-binding domain 1 protein
H0I41_RS05120	COG0793	Belongs to the peptidase S41A family
H0I41_RS05125	COG4479	Belongs to the UPF0346 family
H0I41_RS05130	COG1307	EDD domain protein, DegV family
H0I41_RS05135	COG1272	protein, Hemolysin III
H0I41_RS05140	COG0617	tRNA 3'-terminal CCA addition
H0I41_RS05145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H0I41_RS05155	COG1715	Restriction endonuclease
H0I41_RS05205	COG1160	GTP binding
H0I41_RS05210	COG0539	negative regulation of cytoplasmic translation
H0I41_RS05215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0I41_RS05220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H0I41_RS05230	COG1187	pseudouridine synthase activity
H0I41_RS05235	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0I41_RS05240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0I41_RS05245	COG0456	acetyltransferase
H0I41_RS05255	COG2996	Protein conserved in bacteria
H0I41_RS05265	COG0205	6-phosphofructokinase activity
H0I41_RS05270	COG0587	DNA-directed DNA polymerase activity
H0I41_RS05280	COG0737	Belongs to the 5'-nucleotidase family
H0I41_RS05285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0I41_RS05295	COG0300	oxidoreductase activity
H0I41_RS05300	COG1234	tRNA 3'-trailer cleavage
H0I41_RS05305	COG2755	lipolytic protein G-D-S-L family
H0I41_RS05305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H0I41_RS05310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0I41_RS05315	COG0322	excinuclease ABC activity
H0I41_RS05320	COG1957	nucleoside hydrolase
H0I41_RS05325	COG0586	Pfam SNARE associated Golgi protein
H0I41_RS05415	COG2723	6-phospho-beta-galactosidase activity
H0I41_RS05425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS05425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS05455	COG1091	dTDP-4-dehydrorhamnose reductase activity
H0I41_RS05460	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H0I41_RS05470	COG1088	dTDP-glucose 4,6-dehydratase activity
H0I41_RS05475	COG2226	methyltransferase
H0I41_RS05505	COG2244	polysaccharide biosynthetic process
H0I41_RS05510	COG0562	UDP-galactopyranose mutase
H0I41_RS05535	COG1215	transferase activity, transferring glycosyl groups
H0I41_RS05565	COG0489	protein tyrosine kinase activity
H0I41_RS05570	COG3944	biosynthesis protein
H0I41_RS05605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0I41_RS05620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0I41_RS05630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0I41_RS05640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0I41_RS05655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0I41_RS05660	COG0268	Binds directly to 16S ribosomal RNA
H0I41_RS05665	COG1466	dna polymerase III delta subunit
H0I41_RS05675	COG1555	photosystem II stabilization
H0I41_RS05675	COG1596	polysaccharide export
H0I41_RS05680	COG3480	Lon protease (S16) C-terminal proteolytic domain
H0I41_RS05685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0I41_RS05690	COG0742	ribosomal rna small subunit methyltransferase
H0I41_RS05700	COG0772	Belongs to the SEDS family
H0I41_RS05710	COG0242	peptide deformylase activity
H0I41_RS05725	COG1597	lipid kinase activity
H0I41_RS05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0I41_RS05745	COG0482	sulfurtransferase activity
H0I41_RS05755	COG1104	cysteine desulfurase activity
H0I41_RS05770	COG0494	nUDIX hydrolase
H0I41_RS05775	COG1278	Cold shock
H0I41_RS05780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0I41_RS05785	COG3599	regulation of cell shape
H0I41_RS05800	COG1799	cell septum assembly
H0I41_RS05805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0I41_RS05815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0I41_RS05820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0I41_RS05825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0I41_RS05830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0I41_RS05845	COG0275	rRNA processing
H0I41_RS05850	COG2001	Belongs to the MraZ family
H0I41_RS05875	COG1077	Cell shape determining protein MreB Mrl
H0I41_RS05880	COG2003	Belongs to the UPF0758 family
H0I41_RS05885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I41_RS05895	COG0525	valine-tRNA ligase activity
H0I41_RS05900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0I41_RS05910	COG1187	pseudouridine synthase activity
H0I41_RS05915	COG0301	tRNA thio-modification
H0I41_RS05920	COG1104	cysteine desulfurase activity
H0I41_RS05925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H0I41_RS05940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0I41_RS05960	COG0772	Belongs to the SEDS family
H0I41_RS05970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0I41_RS05980	COG1077	Cell shape determining protein MreB Mrl
H0I41_RS05990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0I41_RS05995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0I41_RS06000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0I41_RS06010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I41_RS06015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0I41_RS06020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I41_RS06025	COG0356	it plays a direct role in the translocation of protons across the membrane
H0I41_RS06035	COG0009	L-threonylcarbamoyladenylate synthase
H0I41_RS06040	COG2890	protein-(glutamine-N5) methyltransferase activity
H0I41_RS06045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0I41_RS06050	COG1435	thymidine kinase activity
H0I41_RS06055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0I41_RS06060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0I41_RS06080	COG0477	Major facilitator Superfamily
H0I41_RS06085	COG0166	Belongs to the GPI family
H0I41_RS06100	COG3850	Histidine kinase
H0I41_RS06100	COG5002	protein histidine kinase activity
H0I41_RS06105	COG0745	RESPONSE REGULATOR receiver
H0I41_RS06115	COG1482	cell wall glycoprotein biosynthetic process
H0I41_RS06310	COG4974	Belongs to the 'phage' integrase family
H0I41_RS06320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0I41_RS06325	COG0827	DNA restriction-modification system
H0I41_RS06345	COG4537	Required for transformation and DNA binding
H0I41_RS06355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0I41_RS06360	COG0217	transcriptional regulatory protein
H0I41_RS06370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0I41_RS06380	COG2267	carboxylic ester hydrolase activity
H0I41_RS06395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0I41_RS06400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0I41_RS06405	COG0561	phosphatase activity
H0I41_RS06410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I41_RS06420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H0I41_RS06430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0I41_RS06440	COG3842	ATPase activity
H0I41_RS06445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0I41_RS06455	COG0802	atpase or kinase
H0I41_RS06460	COG0280	phosphate acetyltransferase
H0I41_RS06465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0I41_RS06470	COG0561	phosphatase activity
H0I41_RS06495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0I41_RS06500	COG0557	exoribonuclease II activity
H0I41_RS06510	COG0148	phosphopyruvate hydratase activity
H0I41_RS06515	COG0149	triose-phosphate isomerase activity
H0I41_RS06520	COG0126	phosphoglycerate kinase activity
H0I41_RS06530	COG2390	Transcriptional regulator
H0I41_RS06535	COG0531	amino acid
H0I41_RS06545	COG1481	regulation of sporulation
H0I41_RS06555	COG1660	Displays ATPase and GTPase activities
H0I41_RS06565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I41_RS06570	COG0556	nucleotide-excision repair
H0I41_RS06575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I41_RS06580	COG2017	converts alpha-aldose to the beta-anomer
H0I41_RS06585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H0I41_RS06590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H0I41_RS06595	COG1874	Beta-galactosidase
H0I41_RS06600	COG2211	Major facilitator Superfamily
H0I41_RS06600	COG2190	(PTS) system
H0I41_RS06605	COG1609	Transcriptional regulator
H0I41_RS06610	COG3250	beta-galactosidase activity
H0I41_RS06615	COG3250	beta-galactosidase activity
H0I41_RS06620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0I41_RS06635	COG0492	ferredoxin-NADP+ reductase activity
H0I41_RS06640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0I41_RS06645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0I41_RS06650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H0I41_RS06665	COG0653	protein targeting
H0I41_RS06680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H0I41_RS06685	COG1739	Uncharacterized protein family UPF0029
H0I41_RS06690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0I41_RS06695	COG1418	mRNA catabolic process
H0I41_RS06700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0I41_RS06710	COG1426	Protein conserved in bacteria
H0I41_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
H0I41_RS06720	COG0612	Peptidase, M16
H0I41_RS06730	COG1280	lysine exporter protein (LysE YggA)
H0I41_RS06730	COG1674	ftsk spoiiie
H0I41_RS06745	COG0628	permease
H0I41_RS06755	COG2706	6-phosphogluconolactonase activity
H0I41_RS06780	COG0564	pseudouridine synthase activity
H0I41_RS06785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0I41_RS06790	COG2357	RelA SpoT domain protein
H0I41_RS06795	COG4116	CYTH
H0I41_RS06815	COG1393	Belongs to the ArsC family
H0I41_RS06825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I41_RS06835	COG0542	response to heat
H0I41_RS06845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0I41_RS06850	COG1253	flavin adenine dinucleotide binding
H0I41_RS06865	COG3557	Belongs to the UPF0374 family
H0I41_RS06870	COG2137	regulation of response to DNA damage stimulus
H0I41_RS06875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0I41_RS06880	COG3425	synthase
H0I41_RS06890	COG0183	Belongs to the thiolase family
H0I41_RS06905	COG0561	phosphatase activity
H0I41_RS06910	COG2814	Major facilitator Superfamily
H0I41_RS06920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0I41_RS06945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0I41_RS06955	COG0768	penicillin binding
H0I41_RS06970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0I41_RS06975	COG0072	phenylalanine-tRNA ligase activity
H0I41_RS06980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0I41_RS06985	COG1733	regulation of RNA biosynthetic process
H0I41_RS06990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I41_RS06995	COG1254	Belongs to the acylphosphatase family
H0I41_RS07000	COG0706	membrane insertase activity
H0I41_RS07005	COG5002	protein histidine kinase activity
H0I41_RS07020	COG1323	Belongs to the UPF0348 family
H0I41_RS07025	COG0799	negative regulation of ribosome biogenesis
H0I41_RS07030	COG1713	HD superfamily hydrolase involved in NAD metabolism
H0I41_RS07035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0I41_RS07040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H0I41_RS07045	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H0I41_RS07050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0I41_RS07055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0I41_RS07065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0I41_RS07085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0I41_RS07090	COG1484	DNA-dependent DNA replication
H0I41_RS07100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0I41_RS07105	COG0237	dephospho-CoA kinase activity
H0I41_RS07110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0I41_RS07115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I41_RS07115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I41_RS07130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0I41_RS07135	COG3142	Participates in the control of copper homeostasis
H0I41_RS07140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I41_RS07145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I41_RS07155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0I41_RS07165	COG1131	(ABC) transporter
H0I41_RS07170	COG0537	adenosine 5'-monophosphoramidase activity
H0I41_RS07185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I41_RS07190	COG3481	metal-dependent phosphohydrolase, HD sub domain
H0I41_RS07200	COG0420	3'-5' exonuclease activity
H0I41_RS07205	COG3679	Belongs to the UPF0342 family
H0I41_RS07210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0I41_RS07215	COG0564	pseudouridine synthase activity
H0I41_RS07235	COG3414	Phosphotransferase system galactitol-specific IIB component
H0I41_RS07240	COG3775	system Galactitol-specific IIC component
H0I41_RS07280	COG3231	kanamycin kinase activity
H0I41_RS07300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0I41_RS07310	COG2217	Heavy metal translocating P-type atpase
H0I41_RS07325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0I41_RS07335	COG1131	(ABC) transporter
H0I41_RS07350	COG4720	Psort location CytoplasmicMembrane, score
H0I41_RS07355	COG1122	ATPase activity
H0I41_RS07385	COG1216	Glycosyl transferase, family 2
H0I41_RS07385	COG1442	glycosyl transferase family 8
H0I41_RS07395	COG0561	phosphatase activity
H0I41_RS07400	COG0675	Transposase, IS605 OrfB family
H0I41_RS07410	COG1597	lipid kinase activity
H0I41_RS07415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0I41_RS07420	COG0154	amidase activity
H0I41_RS07425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0I41_RS07435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I41_RS07445	COG1705	Flagellar rod assembly protein muramidase FlgJ
H0I41_RS07450	COG4684	Psort location CytoplasmicMembrane, score
H0I41_RS07460	COG3091	SprT-like family
H0I41_RS07475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H0I41_RS07485	COG1132	(ABC) transporter
H0I41_RS07495	COG0464	growth
H0I41_RS07500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0I41_RS07505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H0I41_RS07510	COG1216	Glycosyl transferase, family 2
H0I41_RS07510	COG0463	Glycosyl transferase, family 2
H0I41_RS07530	COG2188	Transcriptional regulator
H0I41_RS07605	COG0656	L-ascorbic acid biosynthetic process
H0I41_RS07610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I41_RS07620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0I41_RS07625	COG1205	dead DEAH box helicase
H0I41_RS07625	COG1111	helicase
H0I41_RS07650	COG1012	belongs to the aldehyde dehydrogenase family
H0I41_RS07650	COG1454	alcohol dehydrogenase
H0I41_RS07655	COG1113	amino acid transport
H0I41_RS07775	COG1368	sulfuric ester hydrolase activity
H0I41_RS07785	COG0438	transferase activity, transferring glycosyl groups
H0I41_RS07790	COG0438	transferase activity, transferring glycosyl groups
H0I41_RS07950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0I41_RS07955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0I41_RS07975	COG1012	belongs to the aldehyde dehydrogenase family
H0I41_RS07990	COG0561	phosphatase activity
H0I41_RS07995	COG1033	growth of symbiont in host cell
H0I41_RS07995	COG2409	Drug exporters of the RND superfamily
H0I41_RS08010	COG2971	BadF BadG BcrA BcrD
H0I41_RS08025	COG1846	Transcriptional regulator
H0I41_RS08040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H0I41_RS08050	COG1175	transmembrane transport
H0I41_RS08055	COG3842	ATPase activity
H0I41_RS08080	COG2176	DNA-directed DNA polymerase activity
H0I41_RS08100	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I41_RS08120	COG1970	mechanosensitive ion channel activity
H0I41_RS08130	COG3716	PTS system mannose fructose sorbose family IID component
H0I41_RS08135	COG3715	PTS system
H0I41_RS08140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS08145	COG2188	Transcriptional regulator
H0I41_RS08160	COG1823	symporter activity
H0I41_RS08165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0I41_RS08170	COG1854	S-ribosylhomocysteine lyase activity
H0I41_RS08180	COG3716	PTS system mannose fructose sorbose family IID component
H0I41_RS08190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS08190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I41_RS08215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0I41_RS08220	COG1072	(Pantothenic acid kinase))
H0I41_RS08230	COG4990	cell redox homeostasis
H0I41_RS08235	COG3973	AAA domain
H0I41_RS08255	COG1737	Transcriptional regulator
H0I41_RS08260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H0I41_RS08265	COG1263	PTS System
H0I41_RS08265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS08265	COG2190	(PTS) system
H0I41_RS08270	COG0708	Exodeoxyribonuclease III
H0I41_RS08280	COG0588	phosphoglycerate mutase activity
H0I41_RS08290	COG1136	(ABC) transporter
H0I41_RS08295	COG0531	amino acid
H0I41_RS08310	COG4555	ABC transporter
H0I41_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0I41_RS08335	COG0194	GDP metabolic process
H0I41_RS08355	COG1780	Probably involved in ribonucleotide reductase function
H0I41_RS08385	COG2966	Psort location CytoplasmicMembrane, score
H0I41_RS08390	COG0488	(ABC) transporter
H0I41_RS08405	COG1316	TRANSCRIPTIONal
H0I41_RS08410	COG1164	Oligoendopeptidase f
H0I41_RS08415	COG1620	l-lactate permease
H0I41_RS08420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0I41_RS08425	COG1121	(ABC) transporter
H0I41_RS08435	COG0640	Transcriptional regulator
H0I41_RS08440	COG0561	phosphatase activity
H0I41_RS08450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0I41_RS08450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0I41_RS08450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I41_RS08455	COG1105	Belongs to the carbohydrate kinase PfkB family
H0I41_RS08460	COG1349	DNA-binding transcription factor activity
H0I41_RS08470	COG1668	transmembrane transport
H0I41_RS08475	COG4152	abc transporter atp-binding protein
H0I41_RS08480	COG1794	racemase activity, acting on amino acids and derivatives
H0I41_RS08485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0I41_RS08490	COG5002	protein histidine kinase activity
H0I41_RS08500	COG1132	(ABC) transporter
H0I41_RS08505	COG1132	(ABC) transporter
H0I41_RS08515	COG0012	GTP binding
H0I41_RS08520	COG4481	Protein conserved in bacteria
H0I41_RS08525	COG1475	DNA binding
H0I41_RS08530	COG1192	Involved in chromosome partitioning
H0I41_RS08540	COG0357	Ribosomal RNA small subunit methyltransferase G
H0I41_RS08565	COG0431	NADPH-dependent FMN reductase
H0I41_RS08570	COG0431	NADPH-dependent FMN reductase
H0I41_RS08590	COG2723	6-phospho-beta-galactosidase activity
H0I41_RS08595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS08595	COG2190	(PTS) system
H0I41_RS08595	COG1263	PTS System
H0I41_RS08600	COG3711	transcriptional antiterminator
H0I41_RS08605	COG1136	(ABC) transporter
H0I41_RS08620	COG0588	phosphoglycerate mutase activity
H0I41_RS08635	COG3022	response to hydroperoxide
H0I41_RS08655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0I41_RS08660	COG0584	glycerophosphoryl diester phosphodiesterase
H0I41_RS08675	COG3104	oligopeptide transport
H0I41_RS08680	COG0710	3-dehydroquinate dehydratase activity
H0I41_RS08695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H0I41_RS08705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H0I41_RS08715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS08715	COG1263	PTS System
H0I41_RS08715	COG2190	(PTS) system
H0I41_RS08730	COG2365	Tyrosine phosphatase family
H0I41_RS08735	COG0351	phosphomethylpyrimidine kinase
H0I41_RS08740	COG3442	glutamine amidotransferase
H0I41_RS08745	COG0531	amino acid
H0I41_RS08755	COG2502	aspartate--ammonia ligase
H0I41_RS08765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H0I41_RS08770	COG1113	amino acid transport
H0I41_RS08775	COG1113	amino acid transport
H0I41_RS08785	COG3716	PTS system mannose fructose sorbose family IID component
H0I41_RS08790	COG3715	PTS system
H0I41_RS08890	COG0531	amino acid
H0I41_RS08895	COG0542	response to heat
H0I41_RS08915	COG2814	Major facilitator Superfamily
H0I41_RS08925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H0I41_RS08930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I41_RS08935	COG1696	Membrane protein involved in D-alanine export
H0I41_RS08940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0I41_RS08980	COG0517	IMP dehydrogenase activity
H0I41_RS09000	COG1132	(ABC) transporter
H0I41_RS09010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H0I41_RS09040	COG3775	system Galactitol-specific IIC component
H0I41_RS09060	COG0577	efflux transmembrane transporter activity
H0I41_RS09060	COG1136	(ABC) transporter
H0I41_RS09060	COG1136	(ABC) transporter
H0I41_RS09060	COG0577	efflux transmembrane transporter activity
H0I41_RS09065	COG1271	oxidase subunit
H0I41_RS09070	COG1294	oxidase, subunit
H0I41_RS09075	COG4988	ABC transporter
H0I41_RS09080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H0I41_RS09095	COG1744	ABC transporter substrate-binding protein PnrA-like
H0I41_RS09100	COG1737	Transcriptional regulator
H0I41_RS09110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0I41_RS09115	COG1263	PTS System
H0I41_RS09115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I41_RS09125	COG0656	L-ascorbic acid biosynthetic process
H0I41_RS09130	COG0363	glucosamine-6-phosphate deaminase activity
H0I41_RS09135	COG1428	Deoxynucleoside kinase
H0I41_RS09140	COG1428	Deoxynucleoside kinase
H0I41_RS09145	COG1304	FMN binding
H0I41_RS09150	COG2252	PERMEase
H0I41_RS09155	COG0789	Transcriptional regulator
H0I41_RS09160	COG2252	PERMEase
H0I41_RS09165	COG2252	PERMEase
H0I41_RS09175	COG0242	peptide deformylase activity
H0I41_RS09205	COG2217	Heavy metal translocating P-type atpase
H0I41_RS09225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I41_RS09230	COG0531	amino acid
H0I41_RS09240	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H0I41_RS09255	COG0477	Major facilitator Superfamily
H0I41_RS09265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0I41_RS09270	COG2252	PERMEase
H0I41_RS09275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0I41_RS09285	COG1193	negative regulation of DNA recombination
H0I41_RS09295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H0I41_RS09300	COG0028	Belongs to the TPP enzyme family
H0I41_RS09305	COG0445	tRNA wobble uridine modification
H0I41_RS09310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0I41_RS09315	COG0706	membrane insertase activity
H0I41_RS09320	COG0594	ribonuclease P activity