locus-tag	class	description
I3F57_RS00010	COG0592	DNA-directed DNA polymerase activity
I3F57_RS00015	COG2501	S4 domain
I3F57_RS00025	COG0187	DNA topoisomerase II activity
I3F57_RS00035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I3F57_RS00050	COG0629	single-stranded DNA binding
I3F57_RS00060	COG1271	oxidase subunit
I3F57_RS00065	COG1294	oxidase, subunit
I3F57_RS00125	COG0561	phosphatase activity
I3F57_RS00145	COG3409	Peptidoglycan-binding domain 1 protein
I3F57_RS00225	COG3409	Peptidoglycan-binding domain 1 protein
I3F57_RS00250	COG0800	Aldolase
I3F57_RS00260	COG2801	Transposase and inactivated derivatives
I3F57_RS00280	COG2814	Major facilitator Superfamily
I3F57_RS00290	COG1033	growth of symbiont in host cell
I3F57_RS00290	COG2409	Drug exporters of the RND superfamily
I3F57_RS00295	COG1309	transcriptional regulator
I3F57_RS00310	COG1732	Glycine betaine
I3F57_RS00340	COG2217	Heavy metal translocating P-type atpase
I3F57_RS00345	COG2217	Heavy metal translocating P-type atpase
I3F57_RS00355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3F57_RS00360	COG0159	tryptophan synthase activity
I3F57_RS00370	COG0135	phosphoribosylanthranilate isomerase activity
I3F57_RS00395	COG2814	Major facilitator Superfamily
I3F57_RS00440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3F57_RS00460	COG0019	diaminopimelate decarboxylase activity
I3F57_RS00465	COG0527	aspartate kinase activity
I3F57_RS00475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3F57_RS00540	COG1131	(ABC) transporter
I3F57_RS00555	COG0305	Participates in initiation and elongation during chromosome replication
I3F57_RS00570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3F57_RS00575	COG1737	Transcriptional regulator
I3F57_RS00580	COG1309	transcriptional regulator
I3F57_RS00585	COG1136	(ABC) transporter
I3F57_RS00585	COG0577	efflux transmembrane transporter activity
I3F57_RS00605	COG2217	Heavy metal translocating P-type atpase
I3F57_RS00610	COG0640	Transcriptional regulator
I3F57_RS00615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS00620	COG0583	DNA-binding transcription factor activity
I3F57_RS00625	COG3620	sequence-specific DNA binding
I3F57_RS00635	COG1131	(ABC) transporter
I3F57_RS00645	COG1328	CTP reductase activity
I3F57_RS00715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3F57_RS00750	COG2252	PERMEase
I3F57_RS00765	COG1116	anion transmembrane transporter activity
I3F57_RS00770	COG4521	taurine ABC transporter
I3F57_RS00775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3F57_RS00780	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3F57_RS00785	COG2391	methyltransferase activity
I3F57_RS00800	COG0346	lactoylglutathione lyase activity
I3F57_RS00860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3F57_RS00885	COG1511	domain protein
I3F57_RS00885	COG1511	domain protein
I3F57_RS00895	COG0477	Major facilitator Superfamily
I3F57_RS00905	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I3F57_RS00910	COG4166	transmembrane transport
I3F57_RS00930	COG1131	(ABC) transporter
I3F57_RS00950	COG1132	(ABC) transporter
I3F57_RS00955	COG1396	sequence-specific DNA binding
I3F57_RS00965	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3F57_RS01005	COG0716	FMN binding
I3F57_RS01020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3F57_RS01030	COG2261	transglycosylase associated protein
I3F57_RS01045	COG1302	Protein conserved in bacteria
I3F57_RS01075	COG3442	glutamine amidotransferase
I3F57_RS01095	COG1192	Involved in chromosome partitioning
I3F57_RS01100	COG1475	DNA binding
I3F57_RS01105	COG4481	Protein conserved in bacteria
I3F57_RS01110	COG0012	GTP binding
I3F57_RS01120	COG0516	GMP reductase activity
I3F57_RS01120	COG0517	IMP dehydrogenase activity
I3F57_RS01140	COG1686	Belongs to the peptidase S11 family
I3F57_RS01145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3F57_RS01155	COG1794	racemase activity, acting on amino acids and derivatives
I3F57_RS01160	COG0656	L-ascorbic acid biosynthetic process
I3F57_RS01165	COG1349	DNA-binding transcription factor activity
I3F57_RS01170	COG2814	Major facilitator Superfamily
I3F57_RS01175	COG1012	belongs to the aldehyde dehydrogenase family
I3F57_RS01195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3F57_RS01200	COG3962	Belongs to the TPP enzyme family
I3F57_RS01205	COG0673	inositol 2-dehydrogenase activity
I3F57_RS01210	COG0673	inositol 2-dehydrogenase activity
I3F57_RS01220	COG0191	fructose-bisphosphate aldolase activity
I3F57_RS01225	COG1942	4-Oxalocrotonate Tautomerase
I3F57_RS01230	COG1737	Transcriptional regulator
I3F57_RS01235	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3F57_RS01250	COG2610	gluconate transmembrane transporter activity
I3F57_RS01260	COG1121	(ABC) transporter
I3F57_RS01275	COG2084	Dehydrogenase
I3F57_RS01280	COG1164	Oligoendopeptidase f
I3F57_RS01285	COG1316	TRANSCRIPTIONal
I3F57_RS01290	COG1114	Component of the transport system for branched-chain amino acids
I3F57_RS01305	COG1216	Glycosyl transferase, family 2
I3F57_RS01335	COG0488	(ABC) transporter
I3F57_RS01360	COG3118	belongs to the thioredoxin family
I3F57_RS01380	COG0683	leucine binding
I3F57_RS01410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS01420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I3F57_RS01425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3F57_RS01450	COG2723	6-phospho-beta-galactosidase activity
I3F57_RS01455	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3F57_RS01475	COG2182	Extracellular solute-binding protein
I3F57_RS01485	COG3583	domain protein
I3F57_RS01485	COG3064	Membrane
I3F57_RS01485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3F57_RS01490	COG1482	cell wall glycoprotein biosynthetic process
I3F57_RS01495	COG2188	Transcriptional regulator
I3F57_RS01500	COG2222	sugar isomerase
I3F57_RS01505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3F57_RS01515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS01520	COG3715	PTS system
I3F57_RS01525	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS01530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS01530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS01540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3F57_RS01545	COG0006	proline dipeptidase activity
I3F57_RS01550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS01555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS01560	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS01565	COG1363	Peptidase, m42
I3F57_RS01575	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3F57_RS01580	COG4166	transmembrane transport
I3F57_RS01605	COG1129	ABC transporter
I3F57_RS01615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I3F57_RS01635	COG0351	phosphomethylpyrimidine kinase
I3F57_RS01640	COG0531	amino acid
I3F57_RS01650	COG1609	Transcriptional regulator
I3F57_RS01665	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3F57_RS01670	COG1879	ABC-type sugar transport system periplasmic component
I3F57_RS01690	COG2814	Major facilitator Superfamily
I3F57_RS01730	COG1131	(ABC) transporter
I3F57_RS01755	COG1053	succinate dehydrogenase
I3F57_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS01790	COG1378	Sugar-specific transcriptional regulator TrmB
I3F57_RS01845	COG1609	Transcriptional regulator
I3F57_RS01855	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS01865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3F57_RS01875	COG0641	radical SAM
I3F57_RS01890	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS01905	COG2801	Transposase and inactivated derivatives
I3F57_RS01915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS01945	COG2801	Transposase and inactivated derivatives
I3F57_RS01955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I3F57_RS01960	COG3711	transcriptional antiterminator
I3F57_RS01965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS01965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3F57_RS01975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS01975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS01975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS01980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS01985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS01985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS01985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS02005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS02010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3F57_RS02030	COG0191	fructose-bisphosphate aldolase activity
I3F57_RS02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS02035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS02060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS02060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS02070	COG3715	PTS system
I3F57_RS02075	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS02080	COG0246	Mannitol dehydrogenase
I3F57_RS02085	COG1461	Dihydroxyacetone kinase
I3F57_RS02090	COG2376	Dihydroxyacetone kinase
I3F57_RS02095	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3F57_RS02100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3F57_RS02105	COG1609	Transcriptional regulator
I3F57_RS02115	COG2390	Transcriptional regulator
I3F57_RS02125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS02130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS02135	COG3715	PTS system
I3F57_RS02140	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS02145	COG0191	fructose-bisphosphate aldolase activity
I3F57_RS02150	COG0471	metal ion transport
I3F57_RS02160	COG0583	DNA-binding transcription factor activity
I3F57_RS02175	COG1122	ATPase activity
I3F57_RS02230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3F57_RS02235	COG1349	DNA-binding transcription factor activity
I3F57_RS02240	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3F57_RS02245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3F57_RS02250	COG1349	DNA-binding transcription factor activity
I3F57_RS02280	COG0477	Major facilitator Superfamily
I3F57_RS02300	COG4221	oxidoreductase activity
I3F57_RS02325	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3F57_RS02330	COG0561	phosphatase activity
I3F57_RS02340	COG1609	Transcriptional regulator
I3F57_RS02345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS02355	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS02370	COG0366	Alpha amylase catalytic
I3F57_RS02375	COG1132	(ABC) transporter
I3F57_RS02380	COG1132	(ABC) transporter
I3F57_RS02400	COG1464	Belongs to the NlpA lipoprotein family
I3F57_RS02425	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I3F57_RS02430	COG1461	Dihydroxyacetone kinase
I3F57_RS02435	COG2376	Dihydroxyacetone kinase
I3F57_RS02460	COG2814	Major facilitator Superfamily
I3F57_RS02480	COG0028	Belongs to the TPP enzyme family
I3F57_RS02495	COG2226	methyltransferase
I3F57_RS02500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3F57_RS02505	COG0174	glutamine synthetase
I3F57_RS02520	COG0789	Transcriptional regulator
I3F57_RS02525	COG0656	L-ascorbic acid biosynthetic process
I3F57_RS02540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3F57_RS02565	COG1131	(ABC) transporter
I3F57_RS02585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3F57_RS02610	COG0308	aminopeptidase N
I3F57_RS02615	COG0531	amino acid
I3F57_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS02645	COG2271	Major facilitator Superfamily
I3F57_RS02650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3F57_RS02655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I3F57_RS02660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3F57_RS02710	COG1396	sequence-specific DNA binding
I3F57_RS02840	COG2801	Transposase and inactivated derivatives
I3F57_RS02895	COG3942	CHAP domain
I3F57_RS02930	COG3843	relaxase mobilization nuclease domain protein
I3F57_RS02960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS02960	COG1263	PTS System
I3F57_RS02965	COG0561	phosphatase activity
I3F57_RS02970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS02970	COG2190	(PTS) system
I3F57_RS02970	COG1263	PTS System
I3F57_RS02985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3F57_RS03000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3F57_RS03015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I3F57_RS03060	COG2801	Transposase and inactivated derivatives
I3F57_RS03075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS03110	COG0783	Belongs to the Dps family
I3F57_RS03115	COG1131	(ABC) transporter
I3F57_RS03125	COG1309	transcriptional regulator
I3F57_RS03175	COG2217	Heavy metal translocating P-type atpase
I3F57_RS03195	COG1174	glycine betaine transport
I3F57_RS03210	COG1136	(ABC) transporter
I3F57_RS03235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3F57_RS03245	COG1780	Probably involved in ribonucleotide reductase function
I3F57_RS03325	COG2190	(PTS) system
I3F57_RS03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS03325	COG1263	PTS System
I3F57_RS03335	COG2801	Transposase and inactivated derivatives
I3F57_RS03360	COG0626	cystathionine gamma-synthase activity
I3F57_RS03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3F57_RS03370	COG0765	amino acid transport
I3F57_RS03380	COG1114	Component of the transport system for branched-chain amino acids
I3F57_RS03425	COG0697	spore germination
I3F57_RS03435	COG1131	(ABC) transporter
I3F57_RS03450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3F57_RS03455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3F57_RS03460	COG1132	(ABC) transporter
I3F57_RS03465	COG1132	(ABC) transporter
I3F57_RS03470	COG2223	nitrite transmembrane transporter activity
I3F57_RS03475	COG2188	Transcriptional regulator
I3F57_RS03480	COG0366	Alpha amylase catalytic
I3F57_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS03485	COG1263	PTS System
I3F57_RS03485	COG2190	(PTS) system
I3F57_RS03495	COG0531	amino acid
I3F57_RS03500	COG0039	L-malate dehydrogenase activity
I3F57_RS03505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3F57_RS03510	COG1278	Cold shock
I3F57_RS03525	COG0488	(ABC) transporter
I3F57_RS03530	COG0702	epimerase
I3F57_RS03540	COG1113	amino acid transport
I3F57_RS03550	COG0025	NhaP-type Na H and K H
I3F57_RS03595	COG0004	ammonium transporteR
I3F57_RS03605	COG1285	pathogenesis
I3F57_RS03630	COG1131	(ABC) transporter
I3F57_RS03640	COG0488	(ABC) transporter
I3F57_RS03645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I3F57_RS03650	COG1573	uracil-dna glycosylase
I3F57_RS03655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3F57_RS03660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3F57_RS03665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3F57_RS03670	COG1215	transferase activity, transferring glycosyl groups
I3F57_RS03680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3F57_RS03685	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I3F57_RS03690	COG1609	Transcriptional regulator
I3F57_RS03695	COG2017	converts alpha-aldose to the beta-anomer
I3F57_RS03720	COG3775	system Galactitol-specific IIC component
I3F57_RS03740	COG3684	Belongs to the aldolase LacD family
I3F57_RS03755	COG1349	DNA-binding transcription factor activity
I3F57_RS03770	COG0419	ATPase involved in DNA repair
I3F57_RS03790	COG1194	a g-specific adenine glycosylase
I3F57_RS03800	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3F57_RS03820	COG0351	phosphomethylpyrimidine kinase
I3F57_RS03835	COG2910	NAD(P)H-binding
I3F57_RS03840	COG1472	Belongs to the glycosyl hydrolase 3 family
I3F57_RS03855	COG4120	Belongs to the binding-protein-dependent transport system permease family
I3F57_RS03865	COG0604	alcohol dehydrogenase
I3F57_RS03875	COG0463	Glycosyl transferase, family 2
I3F57_RS03880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3F57_RS03890	COG0745	RESPONSE REGULATOR receiver
I3F57_RS03895	COG5002	protein histidine kinase activity
I3F57_RS03920	COG0778	Nitroreductase
I3F57_RS03925	COG1304	FMN binding
I3F57_RS03960	COG0604	alcohol dehydrogenase
I3F57_RS03975	COG0628	permease
I3F57_RS04000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3F57_RS04010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3F57_RS04015	COG3189	MarR family transcriptional regulator
I3F57_RS04040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I3F57_RS04065	COG0300	oxidoreductase activity
I3F57_RS04070	COG0105	UTP biosynthetic process
I3F57_RS04075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS04080	COG2267	carboxylic ester hydrolase activity
I3F57_RS04110	COG2267	carboxylic ester hydrolase activity
I3F57_RS04145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3F57_RS04170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3F57_RS04175	COG0343	queuine tRNA-ribosyltransferase activity
I3F57_RS04180	COG1862	Preprotein translocase
I3F57_RS04185	COG1454	alcohol dehydrogenase
I3F57_RS04185	COG1012	belongs to the aldehyde dehydrogenase family
I3F57_RS04195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3F57_RS04200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3F57_RS04205	COG4109	DRTGG domain
I3F57_RS04210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3F57_RS04215	COG0513	Belongs to the DEAD box helicase family
I3F57_RS04260	COG3118	belongs to the thioredoxin family
I3F57_RS04275	COG1696	Membrane protein involved in D-alanine export
I3F57_RS04285	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I3F57_RS04290	COG1719	4-vinyl reductase, 4VR
I3F57_RS04295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3F57_RS04305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3F57_RS04320	COG0668	transmembrane transport
I3F57_RS04335	COG1827	regulation of RNA biosynthetic process
I3F57_RS04340	COG0006	proline dipeptidase activity
I3F57_RS04345	COG1609	Transcriptional regulator
I3F57_RS04350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3F57_RS04355	COG1011	Hydrolase
I3F57_RS04395	COG0737	Belongs to the 5'-nucleotidase family
I3F57_RS04400	COG4470	Protein conserved in bacteria
I3F57_RS04405	COG0647	UMP catabolic process
I3F57_RS04415	COG0586	Pfam SNARE associated Golgi protein
I3F57_RS04420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3F57_RS04435	COG1098	S1 RNA binding domain
I3F57_RS04585	COG0531	amino acid
I3F57_RS04590	COG0438	transferase activity, transferring glycosyl groups
I3F57_RS04595	COG0438	transferase activity, transferring glycosyl groups
I3F57_RS04615	COG0436	Aminotransferase
I3F57_RS04625	COG1368	sulfuric ester hydrolase activity
I3F57_RS04630	COG0735	belongs to the Fur family
I3F57_RS04675	COG0477	Major facilitator Superfamily
I3F57_RS04690	COG2814	Major facilitator Superfamily
I3F57_RS04700	COG0671	phosphoesterase, PA-phosphatase related
I3F57_RS04710	COG2244	polysaccharide biosynthetic process
I3F57_RS04715	COG1187	pseudouridine synthase activity
I3F57_RS04725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I3F57_RS04745	COG0438	transferase activity, transferring glycosyl groups
I3F57_RS04750	COG0386	Belongs to the glutathione peroxidase family
I3F57_RS04755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3F57_RS04765	COG3830	Belongs to the UPF0237 family
I3F57_RS04790	COG2357	RelA SpoT domain protein
I3F57_RS04800	COG0564	pseudouridine synthase activity
I3F57_RS04810	COG3142	Participates in the control of copper homeostasis
I3F57_RS04820	COG2706	6-phosphogluconolactonase activity
I3F57_RS04830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3F57_RS04845	COG2226	methyltransferase
I3F57_RS04850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3F57_RS04860	COG1674	ftsk spoiiie
I3F57_RS04865	COG0612	Peptidase, M16
I3F57_RS04870	COG0612	Peptidase, M16
I3F57_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS04880	COG1426	Protein conserved in bacteria
I3F57_RS04885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3F57_RS04895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I3F57_RS04905	COG1739	Uncharacterized protein family UPF0029
I3F57_RS04910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I3F57_RS04935	COG2884	Cell division ATP-binding protein ftsE
I3F57_RS04940	COG2177	Part of the ABC transporter FtsEX involved in
I3F57_RS04950	COG0745	RESPONSE REGULATOR receiver
I3F57_RS04955	COG5002	protein histidine kinase activity
I3F57_RS04965	COG0573	inorganic phosphate transmembrane transporter activity
I3F57_RS04970	COG0581	inorganic phosphate transmembrane transporter activity
I3F57_RS04975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3F57_RS04980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3F57_RS04985	COG0704	Plays a role in the regulation of phosphate uptake
I3F57_RS05000	COG1950	PFAM Membrane protein of
I3F57_RS05010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3F57_RS05020	COG0492	ferredoxin-NADP+ reductase activity
I3F57_RS05025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3F57_RS05030	COG0745	RESPONSE REGULATOR receiver
I3F57_RS05035	COG2205	protein histidine kinase activity
I3F57_RS05040	COG1136	(ABC) transporter
I3F57_RS05060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3F57_RS05075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3F57_RS05085	COG1846	Transcriptional regulator
I3F57_RS05100	COG2390	Transcriptional regulator
I3F57_RS05140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3F57_RS05150	COG0557	exoribonuclease II activity
I3F57_RS05160	COG1609	Transcriptional regulator
I3F57_RS05165	COG0366	Alpha amylase catalytic
I3F57_RS05180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3F57_RS05210	COG0395	ABC-type sugar transport system, permease component
I3F57_RS05215	COG1175	transmembrane transport
I3F57_RS05235	COG0561	phosphatase activity
I3F57_RS05245	COG0280	phosphate acetyltransferase
I3F57_RS05250	COG0802	atpase or kinase
I3F57_RS05255	COG4152	abc transporter atp-binding protein
I3F57_RS05260	COG1668	transmembrane transport
I3F57_RS05275	COG0708	Exodeoxyribonuclease III
I3F57_RS05290	COG1396	sequence-specific DNA binding
I3F57_RS05290	COG3800	Transcriptional regulator
I3F57_RS05300	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3F57_RS05305	COG1177	transmembrane transport
I3F57_RS05310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3F57_RS05325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS05330	COG1309	transcriptional regulator
I3F57_RS05360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3F57_RS05385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3F57_RS05390	COG1459	type II secretion system
I3F57_RS05420	COG0827	DNA restriction-modification system
I3F57_RS05430	COG1113	amino acid transport
I3F57_RS05475	COG3620	sequence-specific DNA binding
I3F57_RS05550	COG4695	Portal protein
I3F57_RS05570	COG2261	transglycosylase associated protein
I3F57_RS05585	COG0745	RESPONSE REGULATOR receiver
I3F57_RS05590	COG5002	protein histidine kinase activity
I3F57_RS05590	COG3850	Histidine kinase
I3F57_RS05620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3F57_RS05680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3F57_RS05685	COG2814	Major facilitator Superfamily
I3F57_RS05690	COG0561	phosphatase activity
I3F57_RS05695	COG2326	polyphosphate kinase activity
I3F57_RS05700	COG3590	peptidase
I3F57_RS05705	COG2814	Major facilitator Superfamily
I3F57_RS05745	COG0673	inositol 2-dehydrogenase activity
I3F57_RS05755	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS05775	COG0514	ATP-dependent DNA helicase (RecQ)
I3F57_RS05780	COG2309	aminopeptidase activity
I3F57_RS05795	COG1295	ribonuclease BN
I3F57_RS05800	COG0716	FMN binding
I3F57_RS05805	COG0024	Methionine aminopeptidase
I3F57_RS05810	COG0463	Glycosyl transferase, family 2
I3F57_RS05830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3F57_RS05895	COG2190	(PTS) system
I3F57_RS05895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS05895	COG1263	PTS System
I3F57_RS05900	COG3711	transcriptional antiterminator
I3F57_RS05905	COG4485	Bacterial membrane protein, YfhO
I3F57_RS05915	COG0463	Glycosyl transferase, family 2
I3F57_RS05925	COG4129	membrane
I3F57_RS05935	COG1278	Cold shock
I3F57_RS05945	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3F57_RS05960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3F57_RS05965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3F57_RS05980	COG1368	sulfuric ester hydrolase activity
I3F57_RS05995	COG4975	Glucose uptake
I3F57_RS06005	COG0582	viral genome integration into host DNA
I3F57_RS06040	COG1396	sequence-specific DNA binding
I3F57_RS06075	COG0419	ATPase involved in DNA repair
I3F57_RS06085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3F57_RS06315	COG0590	tRNA wobble adenosine to inosine editing
I3F57_RS06340	COG1396	sequence-specific DNA binding
I3F57_RS06375	COG5377	YqaJ viral recombinase family
I3F57_RS06385	COG3723	Recombinational DNA repair protein, rece pathway
I3F57_RS06460	COG0740	serine-type endopeptidase activity
I3F57_RS06545	COG3942	CHAP domain
I3F57_RS06545	COG1388	LysM domain
I3F57_RS06570	COG2814	Major facilitator Superfamily
I3F57_RS06575	COG3548	integral membrane protein
I3F57_RS06625	COG2514	catechol 2,3-dioxygenase activity
I3F57_RS06635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3F57_RS06640	COG1435	thymidine kinase activity
I3F57_RS06650	COG2890	protein-(glutamine-N5) methyltransferase activity
I3F57_RS06655	COG0009	L-threonylcarbamoyladenylate synthase
I3F57_RS06670	COG0356	it plays a direct role in the translocation of protons across the membrane
I3F57_RS06715	COG1077	Cell shape determining protein MreB Mrl
I3F57_RS06735	COG0772	Belongs to the SEDS family
I3F57_RS06740	COG0509	glycine decarboxylation via glycine cleavage system
I3F57_RS06745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3F57_RS06750	COG1464	Belongs to the NlpA lipoprotein family
I3F57_RS06755	COG1464	Belongs to the NlpA lipoprotein family
I3F57_RS06765	COG2011	ABC-type metal ion transport system permease component
I3F57_RS06775	COG0719	Fe-S assembly protein
I3F57_RS06780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3F57_RS06785	COG0822	iron-sulfur transferase activity
I3F57_RS06790	COG0719	Fe-S assembly protein
I3F57_RS06820	COG0589	response to stress
I3F57_RS06830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3F57_RS06835	COG0189	ligase activity
I3F57_RS06835	COG2918	glutathione biosynthetic process
I3F57_RS06840	COG5506	Protein of unknown function (DUF1694)
I3F57_RS06850	COG1760	l-serine dehydratase
I3F57_RS06855	COG1760	l-serine dehydratase
I3F57_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS06880	COG1428	Deoxynucleoside kinase
I3F57_RS06890	COG4166	transmembrane transport
I3F57_RS06895	COG2205	protein histidine kinase activity
I3F57_RS06900	COG0745	RESPONSE REGULATOR receiver
I3F57_RS06915	COG0583	DNA-binding transcription factor activity
I3F57_RS06975	COG1307	EDD domain protein, DegV family
I3F57_RS06980	COG2197	response regulator
I3F57_RS06985	COG4585	Histidine kinase
I3F57_RS06995	COG1131	(ABC) transporter
I3F57_RS07005	COG0789	Transcriptional regulator
I3F57_RS07045	COG2183	response to ionizing radiation
I3F57_RS07050	COG3620	sequence-specific DNA binding
I3F57_RS07085	COG1956	GAF domain-containing protein
I3F57_RS07090	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I3F57_RS07095	COG1104	cysteine desulfurase activity
I3F57_RS07105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3F57_RS07110	COG0525	valine-tRNA ligase activity
I3F57_RS07125	COG2003	Belongs to the UPF0758 family
I3F57_RS07130	COG1077	Cell shape determining protein MreB Mrl
I3F57_RS07135	COG1792	Involved in formation and maintenance of cell shape
I3F57_RS07145	COG0850	regulation of cytokinetic process
I3F57_RS07150	COG2894	cell division
I3F57_RS07155	COG0765	amino acid transport
I3F57_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3F57_RS07170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3F57_RS07185	COG2001	Belongs to the MraZ family
I3F57_RS07200	COG0768	penicillin binding
I3F57_RS07230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3F57_RS07250	COG3599	regulation of cell shape
I3F57_RS07260	COG1278	Cold shock
I3F57_RS07285	COG3853	Toxic anion resistance protein (TelA)
I3F57_RS07295	COG0494	nUDIX hydrolase
I3F57_RS07310	COG1104	cysteine desulfurase activity
I3F57_RS07340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3F57_RS07350	COG1597	lipid kinase activity
I3F57_RS07415	COG0483	inositol monophosphate 1-phosphatase activity
I3F57_RS07420	COG1217	gtp-binding protein TYPA
I3F57_RS07425	COG0772	Belongs to the SEDS family
I3F57_RS07430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3F57_RS07435	COG4471	UPF0298 protein
I3F57_RS07440	COG0742	ribosomal rna small subunit methyltransferase
I3F57_RS07450	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3F57_RS07460	COG0658	competence protein
I3F57_RS07460	COG2333	competence protein COMEC
I3F57_RS07465	COG1466	dna polymerase III delta subunit
I3F57_RS07505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3F57_RS07520	COG1132	(ABC) transporter
I3F57_RS07530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3F57_RS07550	COG0765	amino acid transport
I3F57_RS07555	COG1126	abc transporter atp-binding protein
I3F57_RS07565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS07565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS07565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS07570	COG1105	Belongs to the carbohydrate kinase PfkB family
I3F57_RS07575	COG1349	DNA-binding transcription factor activity
I3F57_RS07585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3F57_RS07585	COG2755	lipolytic protein G-D-S-L family
I3F57_RS07595	COG0300	oxidoreductase activity
I3F57_RS07605	COG0542	response to heat
I3F57_RS07620	COG0737	Belongs to the 5'-nucleotidase family
I3F57_RS07635	COG0587	DNA-directed DNA polymerase activity
I3F57_RS07655	COG2996	Protein conserved in bacteria
I3F57_RS07665	COG0456	acetyltransferase
I3F57_RS07670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3F57_RS07675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3F57_RS07680	COG1187	pseudouridine synthase activity
I3F57_RS07685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I3F57_RS07700	COG0514	ATP-dependent DNA helicase (RecQ)
I3F57_RS07715	COG0539	negative regulation of cytoplasmic translation
I3F57_RS07730	COG0457	Tetratricopeptide repeat
I3F57_RS07735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3F57_RS07750	COG0488	(ABC) transporter
I3F57_RS07765	COG1272	protein, Hemolysin III
I3F57_RS07770	COG1307	EDD domain protein, DegV family
I3F57_RS07775	COG2755	lipolytic protein G-D-S-L family
I3F57_RS07785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3F57_RS07795	COG3409	Peptidoglycan-binding domain 1 protein
I3F57_RS07795	COG0793	Belongs to the peptidase S41A family
I3F57_RS07840	COG0758	DNA mediated transformation
I3F57_RS07845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3F57_RS07865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I3F57_RS07880	COG0187	DNA topoisomerase II activity
I3F57_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3F57_RS07890	COG1882	Formate acetyltransferase
I3F57_RS07895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3F57_RS07900	COG0583	DNA-binding transcription factor activity
I3F57_RS07905	COG1227	inorganic diphosphatase activity
I3F57_RS07910	COG4974	Belongs to the 'phage' integrase family
I3F57_RS07920	COG0577	efflux transmembrane transporter activity
I3F57_RS07925	COG1136	(ABC) transporter
I3F57_RS07930	COG5002	protein histidine kinase activity
I3F57_RS07935	COG0745	RESPONSE REGULATOR receiver
I3F57_RS07955	COG0778	Nitroreductase
I3F57_RS07960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3F57_RS07995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3F57_RS08010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3F57_RS08020	COG0494	nUDIX hydrolase
I3F57_RS08025	COG1307	EDD domain protein, DegV family
I3F57_RS08030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I3F57_RS08045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3F57_RS08050	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3F57_RS08055	COG0022	dehydrogenase e1 component
I3F57_RS08060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I3F57_RS08065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3F57_RS08070	COG3426	butyrate kinase activity
I3F57_RS08075	COG0280	phosphate acetyltransferase
I3F57_RS08080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3F57_RS08085	COG0284	orotidine-5'-phosphate decarboxylase activity
I3F57_RS08100	COG0505	Belongs to the CarA family
I3F57_RS08105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3F57_RS08115	COG2233	PERMEase
I3F57_RS08120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3F57_RS08125	COG0564	pseudouridine synthase activity
I3F57_RS08130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3F57_RS08145	COG0328	RNA-DNA hybrid ribonuclease activity
I3F57_RS08155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3F57_RS08170	COG1393	Belongs to the ArsC family
I3F57_RS08175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3F57_RS08180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3F57_RS08185	COG0583	DNA-binding transcription factor activity
I3F57_RS08190	COG3590	peptidase
I3F57_RS08195	COG0095	Lipoate-protein ligase
I3F57_RS08210	COG0116	Belongs to the methyltransferase superfamily
I3F57_RS08235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3F57_RS08240	COG2131	deaminase
I3F57_RS08245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3F57_RS08260	COG0436	Aminotransferase
I3F57_RS08270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3F57_RS08270	COG1199	ATP-dependent helicase activity
I3F57_RS08300	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I3F57_RS08300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I3F57_RS08315	COG2151	metal-sulfur cluster biosynthetic enzyme
I3F57_RS08320	COG1942	4-Oxalocrotonate Tautomerase
I3F57_RS08325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3F57_RS08330	COG2384	SAM-dependent methyltransferase
I3F57_RS08335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3F57_RS08340	COG0358	DNA primase activity
I3F57_RS08370	COG1381	Involved in DNA repair and RecF pathway recombination
I3F57_RS08380	COG0295	cytidine deaminase activity
I3F57_RS08395	COG1702	phosphate starvation-inducible protein PhoH
I3F57_RS08400	COG1610	YqeY-like protein
I3F57_RS08415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3F57_RS08420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3F57_RS08425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3F57_RS08445	COG2130	NADP-dependent
I3F57_RS08470	COG1131	(ABC) transporter
I3F57_RS08480	COG3103	Sh3 type 3 domain protein
I3F57_RS08480	COG4991	sh3 domain protein
I3F57_RS08480	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3F57_RS08495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3F57_RS08505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3F57_RS08520	COG2094	Belongs to the DNA glycosylase MPG family
I3F57_RS08590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3F57_RS08600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I3F57_RS08600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3F57_RS08635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3F57_RS08645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3F57_RS08650	COG0196	riboflavin kinase activity
I3F57_RS08660	COG0861	Integral membrane protein TerC family
I3F57_RS08680	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I3F57_RS08685	COG0195	Participates in both transcription termination and antitermination
I3F57_RS08705	COG0750	zinc metalloprotease
I3F57_RS08710	COG4589	Belongs to the CDS family
I3F57_RS08715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3F57_RS08745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3F57_RS08750	COG0204	Acyl-transferase
I3F57_RS08755	COG0531	amino acid
I3F57_RS08765	COG1132	(ABC) transporter
I3F57_RS08770	COG1132	(ABC) transporter
I3F57_RS08775	COG3763	UPF0154 protein
I3F57_RS08780	COG4224	UPF0291 protein
I3F57_RS08805	COG1837	Belongs to the UPF0109 family
I3F57_RS08815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3F57_RS08830	COG0552	protein localization to endoplasmic reticulum
I3F57_RS08835	COG1196	nuclear chromosome segregation
I3F57_RS08840	COG0571	ribonuclease III activity
I3F57_RS08845	COG0747	negative chemotaxis
I3F57_RS08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3F57_RS08855	COG0601	transmembrane transport
I3F57_RS08860	COG4608	Belongs to the ABC transporter superfamily
I3F57_RS08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3F57_RS08880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3F57_RS08885	COG1461	Dihydroxyacetone kinase
I3F57_RS08900	COG1564	THIamine pyrophosphokinase
I3F57_RS08905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3F57_RS08910	COG1162	GTPase activity
I3F57_RS08915	COG0515	serine threonine protein kinase
I3F57_RS08915	COG2815	serine threonine protein kinase
I3F57_RS08925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3F57_RS08925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I3F57_RS08935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3F57_RS08940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3F57_RS08950	COG0194	GDP metabolic process
I3F57_RS08965	COG0497	DNA recombination
I3F57_RS08970	COG1438	arginine binding
I3F57_RS08975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I3F57_RS08980	COG0142	geranyltranstransferase activity
I3F57_RS08985	COG1722	exodeoxyribonuclease VII activity
I3F57_RS09005	COG1302	Protein conserved in bacteria
I3F57_RS09010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3F57_RS09015	COG0006	proline dipeptidase activity
I3F57_RS09020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3F57_RS09025	COG2868	ribosomal protein
I3F57_RS09030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3F57_RS09060	COG0789	Transcriptional regulator
I3F57_RS09065	COG1982	Orn Lys Arg decarboxylase major
I3F57_RS09070	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I3F57_RS09085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3F57_RS09090	COG1940	carbohydrate kinase activity
I3F57_RS09100	COG0457	Tetratricopeptide repeat
I3F57_RS09100	COG0705	Rhomboid family
I3F57_RS09105	COG0768	penicillin binding
I3F57_RS09115	COG4841	protein insertion into membrane
I3F57_RS09120	COG2197	response regulator
I3F57_RS09135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3F57_RS09140	COG0572	uridine kinase
I3F57_RS09145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3F57_RS09150	COG0072	phenylalanine-tRNA ligase activity
I3F57_RS09160	COG1733	regulation of RNA biosynthetic process
I3F57_RS09170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3F57_RS09180	COG0706	membrane insertase activity
I3F57_RS09185	COG5002	protein histidine kinase activity
I3F57_RS09190	COG0745	RESPONSE REGULATOR receiver
I3F57_RS09195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3F57_RS09215	COG2226	methyltransferase
I3F57_RS09220	COG0799	negative regulation of ribosome biogenesis
I3F57_RS09230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3F57_RS09235	COG1534	Rna-binding protein
I3F57_RS09240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I3F57_RS09245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I3F57_RS09250	COG0346	lactoylglutathione lyase activity
I3F57_RS09260	COG0400	carboxylic ester hydrolase activity
I3F57_RS09285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3F57_RS09315	COG1484	DNA-dependent DNA replication
I3F57_RS09320	COG3611	Membrane attachment protein
I3F57_RS09330	COG0237	dephospho-CoA kinase activity
I3F57_RS09335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3F57_RS09340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3F57_RS09340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3F57_RS09345	COG0670	Belongs to the BI1 family
I3F57_RS09355	COG1674	ftsk spoiiie
I3F57_RS09360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3F57_RS09365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3F57_RS09390	COG1131	(ABC) transporter
I3F57_RS09395	COG0537	adenosine 5'-monophosphoramidase activity
I3F57_RS09405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3F57_RS09420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3F57_RS09425	COG0564	pseudouridine synthase activity
I3F57_RS09430	COG1438	arginine binding
I3F57_RS09435	COG0018	arginyl-trna synthetase
I3F57_RS09455	COG0167	dihydroorotate dehydrogenase activity
I3F57_RS09470	COG1393	Belongs to the ArsC family
I3F57_RS09475	COG1234	tRNA 3'-trailer cleavage
I3F57_RS09490	COG1136	(ABC) transporter
I3F57_RS09495	COG0745	RESPONSE REGULATOR receiver
I3F57_RS09500	COG0642	Histidine kinase
I3F57_RS09510	COG2217	Heavy metal translocating P-type atpase
I3F57_RS09515	COG3682	Transcriptional regulator
I3F57_RS09525	COG0151	Belongs to the GarS family
I3F57_RS09535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3F57_RS09540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3F57_RS09560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3F57_RS09570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3F57_RS09575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3F57_RS09585	COG2814	Major facilitator Superfamily
I3F57_RS09595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS09605	COG0542	response to heat
I3F57_RS09620	COG1253	flavin adenine dinucleotide binding
I3F57_RS09625	COG0628	permease
I3F57_RS09640	COG3557	Belongs to the UPF0374 family
I3F57_RS09660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3F57_RS09670	COG2188	Transcriptional regulator
I3F57_RS09675	COG2723	6-phospho-beta-galactosidase activity
I3F57_RS09680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS09695	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS09700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS09705	COG0028	Belongs to the TPP enzyme family
I3F57_RS09710	COG3425	synthase
I3F57_RS09720	COG0183	Belongs to the thiolase family
I3F57_RS09745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3F57_RS09770	COG3091	SprT-like family
I3F57_RS09775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I3F57_RS09780	COG4120	Belongs to the binding-protein-dependent transport system permease family
I3F57_RS09815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3F57_RS09820	COG2188	Transcriptional regulator
I3F57_RS09825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3F57_RS09830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3F57_RS09835	COG1506	peptidase
I3F57_RS09835	COG0823	Involved in the tonB-independent uptake of proteins
I3F57_RS09835	COG4946	Tricorn protease homolog
I3F57_RS09850	COG3104	oligopeptide transport
I3F57_RS09855	COG0577	efflux transmembrane transporter activity
I3F57_RS09855	COG1136	(ABC) transporter
I3F57_RS09980	COG0833	amino acid
I3F57_RS09990	COG0028	Belongs to the TPP enzyme family
I3F57_RS10030	COG0564	pseudouridine synthase activity
I3F57_RS10050	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I3F57_RS10050	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I3F57_RS10065	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I3F57_RS10065	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I3F57_RS10100	COG0511	ligase activity, forming carbon-carbon bonds
I3F57_RS10110	COG2851	Citrate transporter
I3F57_RS10150	COG1131	(ABC) transporter
I3F57_RS10165	COG2814	Major facilitator Superfamily
I3F57_RS10185	COG1725	Transcriptional regulator
I3F57_RS10190	COG1131	(ABC) transporter
I3F57_RS10205	COG0577	efflux transmembrane transporter activity
I3F57_RS10205	COG1136	(ABC) transporter
I3F57_RS10215	COG4608	Belongs to the ABC transporter superfamily
I3F57_RS10220	COG0444	Belongs to the ABC transporter superfamily
I3F57_RS10230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3F57_RS10235	COG0601	transmembrane transport
I3F57_RS10240	COG4166	transmembrane transport
I3F57_RS10250	COG0640	Transcriptional regulator
I3F57_RS10265	COG1132	(ABC) transporter
I3F57_RS10295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3F57_RS10295	COG5549	protein import
I3F57_RS10300	COG1349	DNA-binding transcription factor activity
I3F57_RS10360	COG1674	ftsk spoiiie
I3F57_RS10375	COG2946	Replication initiation factor
I3F57_RS10405	COG0433	COG0433 Predicted ATPase
I3F57_RS10415	COG0791	NLP P60 protein
I3F57_RS10415	COG0741	lytic transglycosylase activity
I3F57_RS10480	COG0582	viral genome integration into host DNA
I3F57_RS10505	COG4690	dipeptidase activity
I3F57_RS10510	COG1607	acyl-coa hydrolase
I3F57_RS10515	COG3973	AAA domain
I3F57_RS10525	COG0569	domain protein
I3F57_RS10525	COG0475	glutathione-regulated potassium exporter activity
I3F57_RS10530	COG2267	carboxylic ester hydrolase activity
I3F57_RS10560	COG1136	(ABC) transporter
I3F57_RS10565	COG0531	amino acid
I3F57_RS10575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3F57_RS10580	COG0726	polysaccharide deacetylase
I3F57_RS10595	COG0489	protein tyrosine kinase activity
I3F57_RS10615	COG1216	Glycosyl transferase, family 2
I3F57_RS10645	COG0463	Glycosyl transferase, family 2
I3F57_RS10650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3F57_RS10660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3F57_RS10680	COG0765	amino acid transport
I3F57_RS10685	COG0765	amino acid transport
I3F57_RS10690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3F57_RS10710	COG0735	belongs to the Fur family
I3F57_RS10720	COG0194	GDP metabolic process
I3F57_RS10735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3F57_RS10760	COG0058	SHG alpha-glucan phosphorylase activity
I3F57_RS10770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3F57_RS10780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3F57_RS10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3F57_RS10795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3F57_RS10805	COG1393	Belongs to the ArsC family
I3F57_RS10830	COG4464	protein tyrosine phosphatase activity
I3F57_RS10835	COG1316	TRANSCRIPTIONal
I3F57_RS10850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3F57_RS10870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3F57_RS10880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3F57_RS10885	COG0562	UDP-galactopyranose mutase
I3F57_RS10930	COG2801	Transposase and inactivated derivatives
I3F57_RS10940	COG0489	protein tyrosine kinase activity
I3F57_RS10955	COG4708	membrane
I3F57_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS10980	COG4608	Belongs to the ABC transporter superfamily
I3F57_RS10985	COG0444	Belongs to the ABC transporter superfamily
I3F57_RS10990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3F57_RS10995	COG0601	transmembrane transport
I3F57_RS11000	COG4166	transmembrane transport
I3F57_RS11005	COG2814	Major facilitator Superfamily
I3F57_RS11010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3F57_RS11020	COG1139	Iron-sulfur cluster binding protein
I3F57_RS11035	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS11055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS11090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3F57_RS11140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I3F57_RS11155	COG1263	PTS System
I3F57_RS11155	COG2190	(PTS) system
I3F57_RS11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS11160	COG0366	Alpha amylase catalytic
I3F57_RS11165	COG1609	Transcriptional regulator
I3F57_RS11175	COG0702	epimerase
I3F57_RS11180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3F57_RS11195	COG0439	Biotin carboxylase
I3F57_RS11205	COG0511	ligase activity, forming carbon-carbon bonds
I3F57_RS11210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3F57_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS11230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3F57_RS11235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3F57_RS11245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I3F57_RS11250	COG2267	carboxylic ester hydrolase activity
I3F57_RS11255	COG1979	alcohol dehydrogenase
I3F57_RS11285	COG1846	Transcriptional regulator
I3F57_RS11290	COG1132	(ABC) transporter
I3F57_RS11295	COG3464	Transposase
I3F57_RS11300	COG0494	nUDIX hydrolase
I3F57_RS11305	COG0588	phosphoglycerate mutase activity
I3F57_RS11325	COG0628	permease
I3F57_RS11340	COG1597	lipid kinase activity
I3F57_RS11345	COG0028	Belongs to the TPP enzyme family
I3F57_RS11390	COG0460	homoserine dehydrogenase
I3F57_RS11395	COG0527	aspartate kinase activity
I3F57_RS11400	COG2268	Band 7 protein
I3F57_RS11415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3F57_RS11420	COG0436	Aminotransferase
I3F57_RS11440	COG1511	domain protein
I3F57_RS11455	COG0367	asparagine synthase
I3F57_RS11475	COG2826	transposase and inactivated derivatives, IS30 family
I3F57_RS11500	COG0142	geranyltranstransferase activity
I3F57_RS11510	COG4152	abc transporter atp-binding protein
I3F57_RS11555	COG1297	OPT oligopeptide transporter protein
I3F57_RS11575	COG0477	Major facilitator Superfamily
I3F57_RS11585	COG2723	6-phospho-beta-galactosidase activity
I3F57_RS11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS11590	COG2190	(PTS) system
I3F57_RS11590	COG1263	PTS System
I3F57_RS11600	COG1132	(ABC) transporter
I3F57_RS11605	COG1132	(ABC) transporter
I3F57_RS11640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3F57_RS11645	COG4988	ABC transporter
I3F57_RS11650	COG1294	oxidase, subunit
I3F57_RS11655	COG1271	oxidase subunit
I3F57_RS11685	COG0697	spore germination
I3F57_RS11690	COG2818	Glycosylase
I3F57_RS11705	COG2365	Tyrosine phosphatase family
I3F57_RS11710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I3F57_RS11720	COG1268	BioY protein
I3F57_RS11725	COG0789	Transcriptional regulator
I3F57_RS11735	COG1063	alcohol dehydrogenase
I3F57_RS11760	COG2264	protein methyltransferase activity
I3F57_RS11770	COG0505	Belongs to the CarA family
I3F57_RS11780	COG1253	flavin adenine dinucleotide binding
I3F57_RS11785	COG2814	Major facilitator Superfamily
I3F57_RS11810	COG0531	amino acid
I3F57_RS11830	COG1266	CAAX protease self-immunity
I3F57_RS11835	COG1316	TRANSCRIPTIONal
I3F57_RS11845	COG1131	(ABC) transporter
I3F57_RS11850	COG1725	Transcriptional regulator
I3F57_RS11855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3F57_RS11860	COG0488	(ABC) transporter
I3F57_RS11870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS11880	COG0456	acetyltransferase
I3F57_RS11880	COG1214	PFAM Peptidase M22, glycoprotease
I3F57_RS11885	COG1214	PFAM Peptidase M22, glycoprotease
I3F57_RS11925	COG0470	DNA polymerase III
I3F57_RS11930	COG3870	Protein conserved in bacteria
I3F57_RS11955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3F57_RS11965	COG0590	tRNA wobble adenosine to inosine editing
I3F57_RS11975	COG2813	Specifically methylates the guanine in position
I3F57_RS11980	COG0392	lysyltransferase activity
I3F57_RS11980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I3F57_RS11990	COG1609	Transcriptional regulator
I3F57_RS12035	COG0477	Major facilitator Superfamily
I3F57_RS12040	COG1012	belongs to the aldehyde dehydrogenase family
I3F57_RS12055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS12065	COG5646	InterPro IPR014922
I3F57_RS12070	COG2096	Adenosyltransferase
I3F57_RS12100	COG0250	Participates in transcription elongation, termination and antitermination
I3F57_RS12130	COG4939	FMN-binding domain protein
I3F57_RS12170	COG1131	(ABC) transporter
I3F57_RS12190	COG3688	RNA-binding protein containing a PIN domain
I3F57_RS12195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3F57_RS12200	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I3F57_RS12210	COG0277	FAD linked oxidase domain protein
I3F57_RS12235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I3F57_RS12240	COG1737	Transcriptional regulator
I3F57_RS12245	COG4377	Putative membrane peptidase family (DUF2324)
I3F57_RS12260	COG4932	domain protein
I3F57_RS12260	COG4886	Leucine-rich repeat (LRR) protein
I3F57_RS12295	COG4956	integral membrane protein (PIN domain superfamily)
I3F57_RS12300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3F57_RS12305	COG0756	dUTP diphosphatase activity
I3F57_RS12310	COG2388	GCN5-related N-acetyl-transferase
I3F57_RS12315	COG3152	Membrane
I3F57_RS12340	COG1131	(ABC) transporter
I3F57_RS12350	COG0574	Belongs to the PEP-utilizing enzyme family
I3F57_RS12350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3F57_RS12355	COG0517	IMP dehydrogenase activity
I3F57_RS12360	COG0588	phosphoglycerate mutase activity
I3F57_RS12375	COG1304	FMN binding
I3F57_RS12410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3F57_RS12430	COG3764	Sortase (surface protein transpeptidase)
I3F57_RS12470	COG1695	Transcriptional regulator
I3F57_RS12515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3F57_RS12520	COG2274	protein secretion by the type I secretion system
I3F57_RS12585	COG0110	maltose O-acetyltransferase activity
I3F57_RS12605	COG4989	oxidoreductase activity
I3F57_RS12610	COG4221	oxidoreductase activity
I3F57_RS12615	COG1902	pentaerythritol trinitrate reductase activity
I3F57_RS12620	COG0114	fumarate hydratase activity
I3F57_RS12630	COG1914	H( )-stimulated, divalent metal cation uptake system
I3F57_RS12635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS12645	COG2814	Major facilitator Superfamily
I3F57_RS12675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3F57_RS12680	COG1121	(ABC) transporter
I3F57_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
I3F57_RS12770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3F57_RS12785	COG0148	phosphopyruvate hydratase activity
I3F57_RS12790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS12810	COG3639	organic phosphonate transmembrane transporter activity
I3F57_RS12830	COG1116	anion transmembrane transporter activity
I3F57_RS12835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3F57_RS12850	COG4555	ABC transporter
I3F57_RS12895	COG0577	efflux transmembrane transporter activity
I3F57_RS12900	COG1136	(ABC) transporter
I3F57_RS12910	COG0789	Transcriptional regulator
I3F57_RS12990	COG0200	Binds to the 23S rRNA
I3F57_RS13100	COG0450	alkyl hydroperoxide reductase
I3F57_RS13145	COG0542	response to heat
I3F57_RS13150	COG4463	regulation of RNA biosynthetic process
I3F57_RS13220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3F57_RS13225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3F57_RS13260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3F57_RS13265	COG0037	tRNA processing
I3F57_RS13270	COG1098	S1 RNA binding domain
I3F57_RS13280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3F57_RS13285	COG2244	polysaccharide biosynthetic process
I3F57_RS13290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3F57_RS13300	COG0039	L-malate dehydrogenase activity
I3F57_RS13315	COG1376	ErfK ybiS ycfS ynhG family protein
I3F57_RS13320	COG0493	'glutamate synthase
I3F57_RS13325	COG0070	glutamate synthase
I3F57_RS13325	COG0069	glutamate synthase activity
I3F57_RS13325	COG0067	glutamate synthase
I3F57_RS13330	COG4708	membrane
I3F57_RS13335	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3F57_RS13365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3F57_RS13410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3F57_RS13415	COG0504	CTP synthase activity
I3F57_RS13435	COG0095	Lipoate-protein ligase
I3F57_RS13440	COG1078	dGTPase activity
I3F57_RS13470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3F57_RS13475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3F57_RS13485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3F57_RS13490	COG4619	ABC transporter
I3F57_RS13495	COG0390	transport system, permease component
I3F57_RS13505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3F57_RS13510	COG4466	Protein conserved in bacteria
I3F57_RS13515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3F57_RS13520	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I3F57_RS13525	COG0084	hydrolase, TatD family'
I3F57_RS13535	COG3684	Belongs to the aldolase LacD family
I3F57_RS13550	COG3290	protein histidine kinase activity
I3F57_RS13565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3F57_RS13565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3F57_RS13575	COG1801	Protein of unknown function DUF72
I3F57_RS13595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3F57_RS13610	COG1881	PFAM PEBP family protein
I3F57_RS13620	COG4086	secreted protein
I3F57_RS13625	COG0248	Ppx GppA phosphatase
I3F57_RS13630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3F57_RS13640	COG4989	oxidoreductase activity
I3F57_RS13645	COG2226	methyltransferase
I3F57_RS13655	COG0534	Mate efflux family protein
I3F57_RS13660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3F57_RS13665	COG1704	LemA family
I3F57_RS13675	COG0577	efflux transmembrane transporter activity
I3F57_RS13675	COG1136	(ABC) transporter
I3F57_RS13680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3F57_RS13690	COG1174	glycine betaine transport
I3F57_RS13695	COG3973	AAA domain
I3F57_RS13720	COG1418	mRNA catabolic process
I3F57_RS13730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3F57_RS13735	COG0667	Aldo Keto reductase
I3F57_RS13740	COG0561	phosphatase activity
I3F57_RS13760	COG0588	phosphoglycerate mutase activity
I3F57_RS13765	COG0561	phosphatase activity
I3F57_RS13780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3F57_RS13785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I3F57_RS13790	COG1811	Na channel or pump
I3F57_RS13800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS13800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3F57_RS13800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS13805	COG1105	Belongs to the carbohydrate kinase PfkB family
I3F57_RS13815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3F57_RS13835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS13835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS13840	COG3715	PTS system
I3F57_RS13845	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS13850	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS13860	COG2723	6-phospho-beta-galactosidase activity
I3F57_RS13865	COG1940	carbohydrate kinase activity
I3F57_RS13880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS13885	COG2188	Transcriptional regulator
I3F57_RS13900	COG3775	system Galactitol-specific IIC component
I3F57_RS13915	COG1349	DNA-binding transcription factor activity
I3F57_RS13965	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS13970	COG3715	PTS system
I3F57_RS13975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS13980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I3F57_RS13990	COG1414	Transcriptional regulator
I3F57_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
I3F57_RS14005	COG0800	Aldolase
I3F57_RS14040	COG0463	Glycosyl transferase, family 2
I3F57_RS14050	COG0586	Pfam SNARE associated Golgi protein
I3F57_RS14055	COG5002	protein histidine kinase activity
I3F57_RS14060	COG0745	RESPONSE REGULATOR receiver
I3F57_RS14070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS14070	COG1263	PTS System
I3F57_RS14090	COG2801	Transposase and inactivated derivatives
I3F57_RS14125	COG3711	transcriptional antiterminator
I3F57_RS14135	COG2190	(PTS) system
I3F57_RS14135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS14135	COG1263	PTS System
I3F57_RS14160	COG3414	Phosphotransferase system galactitol-specific IIB component
I3F57_RS14165	COG3775	system Galactitol-specific IIC component
I3F57_RS14200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I3F57_RS14215	COG2204	response regulator
I3F57_RS14240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3F57_RS14245	COG0800	Aldolase
I3F57_RS14265	COG3964	amidohydrolase
I3F57_RS14310	COG3732	PTS system glucitol sorbitol-specific
I3F57_RS14315	COG3730	PTS system glucitol sorbitol-specific
I3F57_RS14325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS14325	COG3711	transcriptional antiterminator
I3F57_RS14340	COG0561	phosphatase activity
I3F57_RS14345	COG3623	hexulose-6-phosphate isomerase
I3F57_RS14350	COG1349	DNA-binding transcription factor activity
I3F57_RS14355	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3F57_RS14370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS14390	COG3775	system Galactitol-specific IIC component
I3F57_RS14400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS14410	COG1349	DNA-binding transcription factor activity
I3F57_RS14425	COG1446	asparaginase
I3F57_RS14430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3F57_RS14435	COG2188	Transcriptional regulator
I3F57_RS14470	COG0456	acetyltransferase
I3F57_RS14500	COG0584	glycerophosphoryl diester phosphodiesterase
I3F57_RS14505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3F57_RS14515	COG0395	ABC-type sugar transport system, permease component
I3F57_RS14525	COG3842	ATPase activity
I3F57_RS14530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3F57_RS14535	COG1335	isochorismatase
I3F57_RS14560	COG4948	Mandelate Racemase Muconate Lactonizing
I3F57_RS14565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3F57_RS14570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3F57_RS14575	COG1737	Transcriptional regulator
I3F57_RS14580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS14585	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS14605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3F57_RS14610	COG1397	ADP-ribosylglycohydrolase
I3F57_RS14615	COG2076	Multidrug Resistance protein
I3F57_RS14655	COG0604	alcohol dehydrogenase
I3F57_RS14660	COG2365	Tyrosine phosphatase family
I3F57_RS14685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3F57_RS14700	COG4166	transmembrane transport
I3F57_RS14715	COG2217	Heavy metal translocating P-type atpase
I3F57_RS14730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3F57_RS14735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3F57_RS14750	COG5002	protein histidine kinase activity
I3F57_RS14755	COG0745	RESPONSE REGULATOR receiver
I3F57_RS14760	COG2267	carboxylic ester hydrolase activity
I3F57_RS14765	COG0765	amino acid transport
I3F57_RS14790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS14795	COG2188	Transcriptional regulator
I3F57_RS14800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS14805	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS14825	COG1335	isochorismatase
I3F57_RS14830	COG2814	Major facilitator Superfamily
I3F57_RS14835	COG2807	transmembrane transport
I3F57_RS14840	COG0667	Aldo Keto reductase
I3F57_RS14850	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS14855	COG3715	PTS system
I3F57_RS14890	COG0765	amino acid transport
I3F57_RS14895	COG1126	abc transporter atp-binding protein
I3F57_RS14935	COG4133	protoheme IX ABC transporter activity
I3F57_RS14940	COG3001	Fructosamine kinase
I3F57_RS14950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3F57_RS14955	COG0765	amino acid transport
I3F57_RS14970	COG0714	Associated with various cellular activities
I3F57_RS14980	COG1305	Transglutaminase-like
I3F57_RS14985	COG0438	transferase activity, transferring glycosyl groups
I3F57_RS14990	COG0110	maltose O-acetyltransferase activity
I3F57_RS14995	COG0561	phosphatase activity
I3F57_RS15020	COG3493	citrate carrier protein
I3F57_RS15025	COG3290	protein histidine kinase activity
I3F57_RS15030	COG4565	transcriptional regulatory protein
I3F57_RS15060	COG1263	PTS System
I3F57_RS15060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS15065	COG2190	(PTS) system
I3F57_RS15065	COG1263	PTS System
I3F57_RS15065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3F57_RS15070	COG3711	transcriptional antiterminator
I3F57_RS15080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3F57_RS15100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3F57_RS15110	COG2213	PTS system mannitol-specific
I3F57_RS15140	COG1136	(ABC) transporter
I3F57_RS15145	COG0577	efflux transmembrane transporter activity
I3F57_RS15155	COG0371	Dehydrogenase
I3F57_RS15160	COG1473	amidohydrolase
I3F57_RS15195	COG0706	membrane insertase activity
I3F57_RS15230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3F57_RS15250	COG3711	transcriptional antiterminator
I3F57_RS15255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS15255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3F57_RS15265	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3F57_RS15280	COG1045	serine acetyltransferase
I3F57_RS15295	COG2801	Transposase and inactivated derivatives
I3F57_RS15320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3F57_RS15330	COG2801	Transposase and inactivated derivatives
I3F57_RS15355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3F57_RS15370	COG1472	Belongs to the glycosyl hydrolase 3 family
I3F57_RS15390	COG1192	Involved in chromosome partitioning
I3F57_RS15495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3F57_RS15520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3F57_RS15525	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3F57_RS15560	COG1472	Belongs to the glycosyl hydrolase 3 family
I3F57_RS15595	COG1192	Involved in chromosome partitioning
I3F57_RS15615	COG3715	PTS system
I3F57_RS15620	COG3716	PTS system mannose fructose sorbose family IID component
I3F57_RS15630	COG0667	Aldo Keto reductase
I3F57_RS15640	COG1063	alcohol dehydrogenase
I3F57_RS15660	COG0366	Alpha amylase catalytic
I3F57_RS15675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3F57_RS15680	COG3842	ATPase activity
I3F57_RS15685	COG0366	Alpha amylase catalytic
I3F57_RS15695	COG1175	transmembrane transport
I3F57_RS15700	COG3833	ABC-type maltose transport systems, permease component
I3F57_RS15705	COG1609	Transcriptional regulator