locus-tag	class	description
CFI14_RS00010	COG0582	viral genome integration into host DNA
CFI14_RS00025	COG0542	response to heat
CFI14_RS00045	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS00050	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS00060	COG1686	Belongs to the peptidase S11 family
CFI14_RS00065	COG0436	Aminotransferase
CFI14_RS00070	COG4703	Protein of unknown function (DUF1797)
CFI14_RS00075	COG1368	sulfuric ester hydrolase activity
CFI14_RS00180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFI14_RS00225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFI14_RS00230	COG0833	amino acid
CFI14_RS00235	COG2040	homocysteine
CFI14_RS00240	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS00250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFI14_RS00255	COG2814	Major facilitator Superfamily
CFI14_RS00265	COG2801	Transposase and inactivated derivatives
CFI14_RS00300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CFI14_RS00310	COG0495	leucyl-tRNA aminoacylation
CFI14_RS00320	COG2244	polysaccharide biosynthetic process
CFI14_RS00325	COG1187	pseudouridine synthase activity
CFI14_RS00330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFI14_RS00335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFI14_RS00345	COG3842	ATPase activity
CFI14_RS00350	COG1175	transmembrane transport
CFI14_RS00365	COG0584	glycerophosphoryl diester phosphodiesterase
CFI14_RS00370	COG1428	Deoxynucleoside kinase
CFI14_RS00375	COG1970	mechanosensitive ion channel activity
CFI14_RS00380	COG1511	domain protein
CFI14_RS00390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFI14_RS00410	COG0561	phosphatase activity
CFI14_RS00430	COG3279	Response regulator of the LytR AlgR family
CFI14_RS00455	COG1846	Transcriptional regulator
CFI14_RS00470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFI14_RS00510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFI14_RS00510	COG0646	methionine synthase
CFI14_RS00515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFI14_RS00525	COG2046	Belongs to the sulfate adenylyltransferase family
CFI14_RS00530	COG0529	Catalyzes the synthesis of activated sulfate
CFI14_RS00535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFI14_RS00545	COG0471	metal ion transport
CFI14_RS00545	COG3273	potassium ion transport
CFI14_RS00550	COG0534	Mate efflux family protein
CFI14_RS00570	COG2153	protein acetylation
CFI14_RS00575	COG0018	arginyl-trna synthetase
CFI14_RS00585	COG1136	(ABC) transporter
CFI14_RS00585	COG0577	efflux transmembrane transporter activity
CFI14_RS00600	COG1376	ErfK ybiS ycfS ynhG family protein
CFI14_RS00605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFI14_RS00610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFI14_RS00620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFI14_RS00625	COG1438	arginine binding
CFI14_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFI14_RS00640	COG3679	Belongs to the UPF0342 family
CFI14_RS00645	COG0420	3'-5' exonuclease activity
CFI14_RS00650	COG4717	serine-type aminopeptidase activity
CFI14_RS00655	COG3481	metal-dependent phosphohydrolase, HD sub domain
CFI14_RS00675	COG0583	DNA-binding transcription factor activity
CFI14_RS00680	COG3976	FMN-binding domain protein
CFI14_RS00680	COG0431	NADPH-dependent FMN reductase
CFI14_RS00680	COG1053	succinate dehydrogenase
CFI14_RS00685	COG1053	succinate dehydrogenase
CFI14_RS00685	COG0431	NADPH-dependent FMN reductase
CFI14_RS00685	COG3976	FMN-binding domain protein
CFI14_RS00700	COG0463	Glycosyl transferase, family 2
CFI14_RS00720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFI14_RS00720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFI14_RS00730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFI14_RS00730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFI14_RS00735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFI14_RS00770	COG2271	Major facilitator Superfamily
CFI14_RS00775	COG4948	Mandelate Racemase Muconate Lactonizing
CFI14_RS00790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFI14_RS00800	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS00835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFI14_RS00845	COG0537	adenosine 5'-monophosphoramidase activity
CFI14_RS00850	COG1131	(ABC) transporter
CFI14_RS00855	COG4473	ABC transporter
CFI14_RS00860	COG0510	thiamine kinase activity
CFI14_RS00865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFI14_RS00900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFI14_RS00905	COG1674	ftsk spoiiie
CFI14_RS00910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFI14_RS00935	COG0719	Fe-S assembly protein
CFI14_RS00940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFI14_RS00950	COG0719	Fe-S assembly protein
CFI14_RS00960	COG1120	ATPase activity
CFI14_RS00965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFI14_RS00970	COG0716	FMN binding
CFI14_RS00995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFI14_RS01000	COG2223	nitrite transmembrane transporter activity
CFI14_RS01005	COG2151	metal-sulfur cluster biosynthetic enzyme
CFI14_RS01030	COG2197	response regulator
CFI14_RS01050	COG0746	molybdenum cofactor guanylyltransferase activity
CFI14_RS01055	COG0315	cyclic pyranopterin monophosphate synthase activity
CFI14_RS01060	COG1763	Mo-molybdopterin cofactor biosynthetic process
CFI14_RS01080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CFI14_RS01085	COG1140	nitrate reductase beta subunit
CFI14_RS01095	COG2181	nitrate reductase activity
CFI14_RS01115	COG3655	Transcriptional regulator
CFI14_RS01130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFI14_RS01130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFI14_RS01135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFI14_RS01140	COG0237	dephospho-CoA kinase activity
CFI14_RS01145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFI14_RS01150	COG3611	Membrane attachment protein
CFI14_RS01155	COG1484	DNA-dependent DNA replication
CFI14_RS01160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFI14_RS01165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFI14_RS01170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFI14_RS01175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFI14_RS01190	COG1051	belongs to the nudix hydrolase family
CFI14_RS01210	COG1857	crispr-associated protein
CFI14_RS01225	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS01240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFI14_RS01245	COG1534	Rna-binding protein
CFI14_RS01250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFI14_RS01255	COG1713	HD superfamily hydrolase involved in NAD metabolism
CFI14_RS01260	COG0799	negative regulation of ribosome biogenesis
CFI14_RS01265	COG2226	methyltransferase
CFI14_RS01270	COG1323	Belongs to the UPF0348 family
CFI14_RS01280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFI14_RS01295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CFI14_RS01300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFI14_RS01305	COG0745	RESPONSE REGULATOR receiver
CFI14_RS01310	COG5002	protein histidine kinase activity
CFI14_RS01325	COG0419	ATPase involved in DNA repair
CFI14_RS01330	COG0420	3'-5' exonuclease activity
CFI14_RS01335	COG4166	transmembrane transport
CFI14_RS01355	COG0706	membrane insertase activity
CFI14_RS01360	COG1254	Belongs to the acylphosphatase family
CFI14_RS01365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFI14_RS01375	COG1733	regulation of RNA biosynthetic process
CFI14_RS01380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFI14_RS01385	COG0072	phenylalanine-tRNA ligase activity
CFI14_RS01385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFI14_RS01390	COG2801	Transposase and inactivated derivatives
CFI14_RS01400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFI14_RS01405	COG0572	uridine kinase
CFI14_RS01410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFI14_RS01425	COG4841	protein insertion into membrane
CFI14_RS01435	COG0768	penicillin binding
CFI14_RS01440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFI14_RS01445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFI14_RS01460	COG1940	carbohydrate kinase activity
CFI14_RS01480	COG2801	Transposase and inactivated derivatives
CFI14_RS01500	COG0584	glycerophosphoryl diester phosphodiesterase
CFI14_RS01505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFI14_RS01510	COG0789	Transcriptional regulator
CFI14_RS01565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFI14_RS01575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFI14_RS01580	COG0006	proline dipeptidase activity
CFI14_RS01585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFI14_RS01590	COG1302	Protein conserved in bacteria
CFI14_RS01595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFI14_RS01600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFI14_RS01605	COG1570	exodeoxyribonuclease VII activity
CFI14_RS01610	COG1722	exodeoxyribonuclease VII activity
CFI14_RS01615	COG0142	geranyltranstransferase activity
CFI14_RS01620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CFI14_RS01625	COG1438	arginine binding
CFI14_RS01630	COG0497	DNA recombination
CFI14_RS01660	COG0194	GDP metabolic process
CFI14_RS01665	COG1758	RNA polymerase activity
CFI14_RS01675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFI14_RS01680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFI14_RS01685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFI14_RS01690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFI14_RS01690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFI14_RS01695	COG0631	protein serine/threonine phosphatase activity
CFI14_RS01700	COG0515	serine threonine protein kinase
CFI14_RS01700	COG2815	serine threonine protein kinase
CFI14_RS01705	COG1162	GTPase activity
CFI14_RS01710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFI14_RS01715	COG1564	THIamine pyrophosphokinase
CFI14_RS01720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFI14_RS01725	COG1302	Protein conserved in bacteria
CFI14_RS01730	COG1461	Dihydroxyacetone kinase
CFI14_RS01735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFI14_RS01740	COG0416	fatty acid biosynthetic process
CFI14_RS01745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFI14_RS01750	COG0571	ribonuclease III activity
CFI14_RS01755	COG1196	nuclear chromosome segregation
CFI14_RS01760	COG0552	protein localization to endoplasmic reticulum
CFI14_RS01765	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CFI14_RS01770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFI14_RS01775	COG0228	four-way junction DNA binding
CFI14_RS01780	COG1837	Belongs to the UPF0109 family
CFI14_RS01785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFI14_RS01790	COG0336	Belongs to the RNA methyltransferase TrmD family
CFI14_RS01795	COG0335	large ribosomal subunit rRNA binding
CFI14_RS01800	COG0477	Major facilitator Superfamily
CFI14_RS01815	COG1131	(ABC) transporter
CFI14_RS01830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFI14_RS01830	COG0512	Glutamine amidotransferase of anthranilate synthase
CFI14_RS01835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFI14_RS01840	COG0134	indole-3-glycerol-phosphate synthase activity
CFI14_RS01845	COG0135	phosphoribosylanthranilate isomerase activity
CFI14_RS01850	COG0133	tryptophan synthase activity
CFI14_RS01855	COG0159	tryptophan synthase activity
CFI14_RS01865	COG0789	Transcriptional regulator
CFI14_RS01870	COG1063	alcohol dehydrogenase
CFI14_RS01885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFI14_RS01890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFI14_RS01895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFI14_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS01910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFI14_RS01915	COG0511	ligase activity, forming carbon-carbon bonds
CFI14_RS01920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFI14_RS01925	COG0439	Biotin carboxylase
CFI14_RS01940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CFI14_RS01950	COG1811	Na channel or pump
CFI14_RS01955	COG0583	DNA-binding transcription factor activity
CFI14_RS01960	COG1607	acyl-coa hydrolase
CFI14_RS01965	COG1162	GTPase activity
CFI14_RS02025	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CFI14_RS02035	COG3152	Membrane
CFI14_RS02040	COG1597	lipid kinase activity
CFI14_RS02060	COG3237	CsbD-like
CFI14_RS02075	COG1942	4-Oxalocrotonate Tautomerase
CFI14_RS02080	COG0019	diaminopimelate decarboxylase activity
CFI14_RS02165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFI14_RS02195	COG0531	amino acid
CFI14_RS02200	COG0561	phosphatase activity
CFI14_RS02205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CFI14_RS02205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFI14_RS02215	COG3835	regulator
CFI14_RS02250	COG2017	converts alpha-aldose to the beta-anomer
CFI14_RS02255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFI14_RS02265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFI14_RS02270	COG0066	3-isopropylmalate dehydratase activity
CFI14_RS02275	COG2271	Major facilitator Superfamily
CFI14_RS02280	COG1304	FMN binding
CFI14_RS02305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFI14_RS02305	COG1199	ATP-dependent helicase activity
CFI14_RS02320	COG0017	Asparaginyl-tRNA synthetase
CFI14_RS02340	COG2801	Transposase and inactivated derivatives
CFI14_RS02350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFI14_RS02355	COG2011	ABC-type metal ion transport system permease component
CFI14_RS02360	COG1464	Belongs to the NlpA lipoprotein family
CFI14_RS02365	COG0589	response to stress
CFI14_RS02400	COG1840	ABC-type Fe3 transport system, periplasmic component
CFI14_RS02405	COG3842	ATPase activity
CFI14_RS02415	COG3331	DNA recombination
CFI14_RS02420	COG4474	Belongs to the UPF0398 family
CFI14_RS02425	COG3599	regulation of cell shape
CFI14_RS02435	COG0116	Belongs to the methyltransferase superfamily
CFI14_RS02440	COG1073	alpha beta
CFI14_RS02450	COG1216	Glycosyl transferase, family 2
CFI14_RS02465	COG1120	ATPase activity
CFI14_RS02500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFI14_RS02515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CFI14_RS02520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFI14_RS02525	COG0564	pseudouridine synthase activity
CFI14_RS02530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFI14_RS02535	COG0505	Belongs to the CarA family
CFI14_RS02540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFI14_RS02555	COG5646	InterPro IPR014922
CFI14_RS02575	COG1131	(ABC) transporter
CFI14_RS02585	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CFI14_RS02595	COG1307	EDD domain protein, DegV family
CFI14_RS02655	COG1113	amino acid transport
CFI14_RS02670	COG1620	l-lactate permease
CFI14_RS02680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFI14_RS02690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFI14_RS02765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFI14_RS02770	COG1227	inorganic diphosphatase activity
CFI14_RS02775	COG0583	DNA-binding transcription factor activity
CFI14_RS02785	COG0187	DNA topoisomerase II activity
CFI14_RS02790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFI14_RS02800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFI14_RS02805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFI14_RS02810	COG4974	Belongs to the 'phage' integrase family
CFI14_RS02815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CFI14_RS02820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFI14_RS02825	COG0758	DNA mediated transformation
CFI14_RS02830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFI14_RS02835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFI14_RS02840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFI14_RS02845	COG0583	DNA-binding transcription factor activity
CFI14_RS02850	COG0477	Major facilitator Superfamily
CFI14_RS02855	COG0793	Belongs to the peptidase S41A family
CFI14_RS02855	COG3409	Peptidoglycan-binding domain 1 protein
CFI14_RS02860	COG4479	Belongs to the UPF0346 family
CFI14_RS02865	COG4698	Protein conserved in bacteria
CFI14_RS02870	COG2755	lipolytic protein G-D-S-L family
CFI14_RS02875	COG1307	EDD domain protein, DegV family
CFI14_RS02880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFI14_RS02885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFI14_RS02890	COG0488	(ABC) transporter
CFI14_RS02900	COG0617	tRNA 3'-terminal CCA addition
CFI14_RS02905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFI14_RS02910	COG0561	phosphatase activity
CFI14_RS02915	COG0457	Tetratricopeptide repeat
CFI14_RS02930	COG1160	GTP binding
CFI14_RS02935	COG0539	negative regulation of cytoplasmic translation
CFI14_RS02940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFI14_RS02950	COG0514	ATP-dependent DNA helicase (RecQ)
CFI14_RS02965	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CFI14_RS02970	COG1187	pseudouridine synthase activity
CFI14_RS02975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFI14_RS02980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFI14_RS02990	COG4974	Belongs to the 'phage' integrase family
CFI14_RS02995	COG2996	Protein conserved in bacteria
CFI14_RS03015	COG0205	6-phosphofructokinase activity
CFI14_RS03020	COG0587	DNA-directed DNA polymerase activity
CFI14_RS03030	COG0542	response to heat
CFI14_RS03040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFI14_RS03045	COG2384	SAM-dependent methyltransferase
CFI14_RS03055	COG2315	Protein conserved in bacteria
CFI14_RS03080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFI14_RS03080	COG0574	Belongs to the PEP-utilizing enzyme family
CFI14_RS03100	COG3052	prosthetic group binding
CFI14_RS03115	COG0583	DNA-binding transcription factor activity
CFI14_RS03135	COG5549	protein import
CFI14_RS03135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFI14_RS03140	COG4221	oxidoreductase activity
CFI14_RS03150	COG1174	glycine betaine transport
CFI14_RS03155	COG0517	IMP dehydrogenase activity
CFI14_RS03155	COG1125	glycine betaine transport
CFI14_RS03160	COG1733	regulation of RNA biosynthetic process
CFI14_RS03165	COG0477	Major facilitator Superfamily
CFI14_RS03200	COG0546	phosphoglycolate phosphatase activity
CFI14_RS03205	COG0110	maltose O-acetyltransferase activity
CFI14_RS03210	COG1737	Transcriptional regulator
CFI14_RS03230	COG2801	Transposase and inactivated derivatives
CFI14_RS03255	COG0583	DNA-binding transcription factor activity
CFI14_RS03260	COG0604	alcohol dehydrogenase
CFI14_RS03265	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS03270	COG2197	response regulator
CFI14_RS03275	COG4585	Histidine kinase
CFI14_RS03285	COG1131	(ABC) transporter
CFI14_RS03300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFI14_RS03305	COG0358	DNA primase activity
CFI14_RS03310	COG0751	glycine-tRNA ligase activity
CFI14_RS03315	COG0752	glycyl-tRNA synthetase alpha subunit
CFI14_RS03320	COG1381	Involved in DNA repair and RecF pathway recombination
CFI14_RS03325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFI14_RS03330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFI14_RS03335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFI14_RS03340	COG1702	phosphate starvation-inducible protein PhoH
CFI14_RS03345	COG2801	Transposase and inactivated derivatives
CFI14_RS03355	COG1610	YqeY-like protein
CFI14_RS03360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFI14_RS03365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFI14_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS03375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFI14_RS03385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFI14_RS03390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFI14_RS03395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFI14_RS03400	COG0124	histidyl-tRNA synthetase
CFI14_RS03405	COG3103	Sh3 type 3 domain protein
CFI14_RS03405	COG4991	sh3 domain protein
CFI14_RS03405	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFI14_RS03415	COG3001	Fructosamine kinase
CFI14_RS03420	COG0546	phosphoglycolate phosphatase activity
CFI14_RS03425	COG1490	D-aminoacyl-tRNA deacylase activity
CFI14_RS03430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFI14_RS03440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFI14_RS03445	COG2264	protein methyltransferase activity
CFI14_RS03450	COG2094	Belongs to the DNA glycosylase MPG family
CFI14_RS03465	COG0481	GTPase activity
CFI14_RS03470	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CFI14_RS03475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFI14_RS03480	COG1696	Membrane protein involved in D-alanine export
CFI14_RS03485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFI14_RS03495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFI14_RS03500	COG0484	heat shock protein binding
CFI14_RS03505	COG0443	Heat shock 70 kDa protein
CFI14_RS03510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFI14_RS03515	COG1420	regulation of RNA biosynthetic process
CFI14_RS03520	COG3527	Alpha-acetolactate decarboxylase
CFI14_RS03525	COG0196	riboflavin kinase activity
CFI14_RS03530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFI14_RS03535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFI14_RS03540	COG0287	Prephenate dehydrogenase
CFI14_RS03545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFI14_RS03555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFI14_RS03560	COG0738	Major facilitator superfamily
CFI14_RS03575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFI14_RS03580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFI14_RS03590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CFI14_RS03595	COG0195	Participates in both transcription termination and antitermination
CFI14_RS03600	COG0779	Required for maturation of 30S ribosomal subunits
CFI14_RS03605	COG2176	DNA-directed DNA polymerase activity
CFI14_RS03610	COG0442	prolyl-tRNA aminoacylation
CFI14_RS03615	COG0750	zinc metalloprotease
CFI14_RS03620	COG4589	Belongs to the CDS family
CFI14_RS03625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFI14_RS03630	COG0233	cytoplasmic translational termination
CFI14_RS03635	COG0528	UMP kinase activity
CFI14_RS03640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFI14_RS03645	COG0052	Belongs to the universal ribosomal protein uS2 family
CFI14_RS03665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFI14_RS03670	COG2827	Endonuclease containing a URI domain
CFI14_RS03675	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFI14_RS03680	COG0204	Acyl-transferase
CFI14_RS03685	COG3763	UPF0154 protein
CFI14_RS03690	COG4224	UPF0291 protein
CFI14_RS03695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFI14_RS03705	COG3425	synthase
CFI14_RS03720	COG0463	Glycosyl transferase, family 2
CFI14_RS03770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFI14_RS03775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CFI14_RS03775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFI14_RS03780	COG5416	Lipopolysaccharide assembly protein A domain
CFI14_RS03785	COG0300	oxidoreductase activity
CFI14_RS03790	COG1234	tRNA 3'-trailer cleavage
CFI14_RS03800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFI14_RS03805	COG1349	DNA-binding transcription factor activity
CFI14_RS03810	COG1105	Belongs to the carbohydrate kinase PfkB family
CFI14_RS03815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS03815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS03815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS03820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CFI14_RS03830	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS03840	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS03845	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS03845	COG0297	glycogen (starch) synthase activity
CFI14_RS03850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFI14_RS03855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFI14_RS03860	COG4464	protein tyrosine phosphatase activity
CFI14_RS03865	COG0489	protein tyrosine kinase activity
CFI14_RS03875	COG0322	excinuclease ABC activity
CFI14_RS03880	COG1126	abc transporter atp-binding protein
CFI14_RS03885	COG0765	amino acid transport
CFI14_RS03905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFI14_RS03910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFI14_RS03915	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFI14_RS03920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFI14_RS03940	COG2814	Major facilitator Superfamily
CFI14_RS03945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFI14_RS03950	COG0268	Binds directly to 16S ribosomal RNA
CFI14_RS03955	COG1466	dna polymerase III delta subunit
CFI14_RS03960	COG0658	competence protein
CFI14_RS03960	COG2333	competence protein COMEC
CFI14_RS03965	COG2131	deaminase
CFI14_RS03970	COG1555	photosystem II stabilization
CFI14_RS03970	COG1596	polysaccharide export
CFI14_RS03980	COG3480	Lon protease (S16) C-terminal proteolytic domain
CFI14_RS03985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFI14_RS03990	COG0742	ribosomal rna small subunit methyltransferase
CFI14_RS03995	COG4471	UPF0298 protein
CFI14_RS04005	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CFI14_RS04010	COG0772	Belongs to the SEDS family
CFI14_RS04045	COG1217	gtp-binding protein TYPA
CFI14_RS04050	COG0483	inositol monophosphate 1-phosphatase activity
CFI14_RS04055	COG4476	Belongs to the UPF0223 family
CFI14_RS04060	COG0039	L-malate dehydrogenase activity
CFI14_RS04095	COG0242	peptide deformylase activity
CFI14_RS04105	COG5503	Protein of unknown function (DUF1447)
CFI14_RS04110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFI14_RS04120	COG2801	Transposase and inactivated derivatives
CFI14_RS04135	COG1388	LysM domain
CFI14_RS04135	COG3584	3D domain protein
CFI14_RS04140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFI14_RS04145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFI14_RS04175	COG0569	domain protein
CFI14_RS04180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFI14_RS04190	COG0482	sulfurtransferase activity
CFI14_RS04200	COG1104	cysteine desulfurase activity
CFI14_RS04205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFI14_RS04215	COG0494	nUDIX hydrolase
CFI14_RS04220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFI14_RS04230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFI14_RS04235	COG3599	regulation of cell shape
CFI14_RS04245	COG0762	integral membrane protein
CFI14_RS04250	COG1799	cell septum assembly
CFI14_RS04255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFI14_RS04265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFI14_RS04270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFI14_RS04275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFI14_RS04280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFI14_RS04285	COG0768	penicillin binding
CFI14_RS04295	COG0275	rRNA processing
CFI14_RS04300	COG2001	Belongs to the MraZ family
CFI14_RS04320	COG1674	ftsk spoiiie
CFI14_RS04325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CFI14_RS04330	COG2910	NAD(P)H-binding
CFI14_RS04335	COG1114	Component of the transport system for branched-chain amino acids
CFI14_RS04350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFI14_RS04355	COG0628	permease
CFI14_RS04365	COG2706	6-phosphogluconolactonase activity
CFI14_RS04370	COG3142	Participates in the control of copper homeostasis
CFI14_RS04375	COG0564	pseudouridine synthase activity
CFI14_RS04380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFI14_RS04385	COG2357	RelA SpoT domain protein
CFI14_RS04405	COG4862	establishment of competence for transformation
CFI14_RS04410	COG1393	Belongs to the ArsC family
CFI14_RS04415	COG1234	tRNA 3'-trailer cleavage
CFI14_RS04560	COG1098	S1 RNA binding domain
CFI14_RS04570	COG0586	Pfam SNARE associated Golgi protein
CFI14_RS04580	COG0647	UMP catabolic process
CFI14_RS04585	COG4470	Protein conserved in bacteria
CFI14_RS04590	COG0737	Belongs to the 5'-nucleotidase family
CFI14_RS04600	COG1113	amino acid transport
CFI14_RS04605	COG0827	DNA restriction-modification system
CFI14_RS04625	COG4537	Required for transformation and DNA binding
CFI14_RS04635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFI14_RS04645	COG0217	transcriptional regulatory protein
CFI14_RS04665	COG1609	Transcriptional regulator
CFI14_RS04670	COG0006	proline dipeptidase activity
CFI14_RS04675	COG3275	phosphorelay sensor kinase activity
CFI14_RS04680	COG3279	Response regulator of the LytR AlgR family
CFI14_RS04690	COG1346	cytolysis
CFI14_RS04695	COG0789	Transcriptional regulator
CFI14_RS04710	COG0668	transmembrane transport
CFI14_RS04725	COG1473	amidohydrolase
CFI14_RS04730	COG2171	N-acyltransferase activity
CFI14_RS04735	COG0517	IMP dehydrogenase activity
CFI14_RS04745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFI14_RS04750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFI14_RS04760	COG3118	belongs to the thioredoxin family
CFI14_RS04765	COG1193	negative regulation of DNA recombination
CFI14_RS04775	COG3906	Belongs to the UPF0473 family
CFI14_RS04780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFI14_RS04785	COG4472	Bacterial protein of unknown function (DUF965)
CFI14_RS04805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFI14_RS04810	COG0513	Belongs to the DEAD box helicase family
CFI14_RS04815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFI14_RS04820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFI14_RS04825	COG1862	Preprotein translocase
CFI14_RS04830	COG0343	queuine tRNA-ribosyltransferase activity
CFI14_RS04835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFI14_RS04840	COG2255	four-way junction helicase activity
CFI14_RS04845	COG0632	four-way junction helicase activity
CFI14_RS04875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CFI14_RS04880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFI14_RS04885	COG1692	metallophosphoesterase
CFI14_RS04890	COG1418	mRNA catabolic process
CFI14_RS04900	COG1546	Belongs to the CinA family
CFI14_RS04900	COG1058	Belongs to the CinA family
CFI14_RS04905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFI14_RS04910	COG1426	Protein conserved in bacteria
CFI14_RS04915	COG0612	Peptidase, M16
CFI14_RS04920	COG0612	Peptidase, M16
CFI14_RS04925	COG0527	aspartate kinase activity
CFI14_RS04930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFI14_RS04935	COG1126	abc transporter atp-binding protein
CFI14_RS04940	COG0765	amino acid transport
CFI14_RS04945	COG2894	cell division
CFI14_RS04960	COG1792	Involved in formation and maintenance of cell shape
CFI14_RS04965	COG1077	Cell shape determining protein MreB Mrl
CFI14_RS04970	COG2003	Belongs to the UPF0758 family
CFI14_RS04985	COG2801	Transposase and inactivated derivatives
CFI14_RS04990	COG0285	dihydrofolate synthase activity
CFI14_RS04995	COG0525	valine-tRNA ligase activity
CFI14_RS05000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CFI14_RS05005	COG2918	glutathione biosynthetic process
CFI14_RS05005	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFI14_RS05010	COG0301	tRNA thio-modification
CFI14_RS05015	COG1104	cysteine desulfurase activity
CFI14_RS05020	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CFI14_RS05025	COG1956	GAF domain-containing protein
CFI14_RS05030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFI14_RS05045	COG4493	Belongs to the UPF0637 family
CFI14_RS05060	COG0640	Transcriptional regulator
CFI14_RS05065	COG1914	H( )-stimulated, divalent metal cation uptake system
CFI14_RS05070	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFI14_RS05075	COG4336	lyase activity
CFI14_RS05080	COG0439	Biotin carboxylase
CFI14_RS05085	COG0511	ligase activity, forming carbon-carbon bonds
CFI14_RS05090	COG1984	allophanate hydrolase subunit 2
CFI14_RS05095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFI14_RS05100	COG0189	ligase activity
CFI14_RS05100	COG2918	glutathione biosynthetic process
CFI14_RS05105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFI14_RS05120	COG0589	response to stress
CFI14_RS05135	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFI14_RS05155	COG1464	Belongs to the NlpA lipoprotein family
CFI14_RS05160	COG2011	ABC-type metal ion transport system permease component
CFI14_RS05165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFI14_RS05170	COG0509	glycine decarboxylation via glycine cleavage system
CFI14_RS05175	COG0772	Belongs to the SEDS family
CFI14_RS05185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFI14_RS05190	COG1077	Cell shape determining protein MreB Mrl
CFI14_RS05195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFI14_RS05200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFI14_RS05205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFI14_RS05210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFI14_RS05215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFI14_RS05220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFI14_RS05225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFI14_RS05230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFI14_RS05235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFI14_RS05240	COG0356	it plays a direct role in the translocation of protons across the membrane
CFI14_RS05245	COG2233	PERMEase
CFI14_RS05250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFI14_RS05255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFI14_RS05260	COG0009	L-threonylcarbamoyladenylate synthase
CFI14_RS05270	COG2890	protein-(glutamine-N5) methyltransferase activity
CFI14_RS05275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFI14_RS05280	COG1435	thymidine kinase activity
CFI14_RS05285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFI14_RS05290	COG3442	glutamine amidotransferase
CFI14_RS05295	COG1482	cell wall glycoprotein biosynthetic process
CFI14_RS05300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFI14_RS05310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFI14_RS05325	COG1132	(ABC) transporter
CFI14_RS05340	COG0726	polysaccharide deacetylase
CFI14_RS05380	COG4886	Leucine-rich repeat (LRR) protein
CFI14_RS05380	COG4932	domain protein
CFI14_RS05425	COG1132	(ABC) transporter
CFI14_RS05430	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS05435	COG0577	efflux transmembrane transporter activity
CFI14_RS05435	COG1136	(ABC) transporter
CFI14_RS05450	COG0166	Belongs to the GPI family
CFI14_RS05455	COG4975	Glucose uptake
CFI14_RS05460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFI14_RS05465	COG5002	protein histidine kinase activity
CFI14_RS05465	COG3850	Histidine kinase
CFI14_RS05470	COG0745	RESPONSE REGULATOR receiver
CFI14_RS05475	COG2848	UPF0210 protein
CFI14_RS05480	COG3830	Belongs to the UPF0237 family
CFI14_RS05510	COG3409	Peptidoglycan-binding domain 1 protein
CFI14_RS05525	COG0477	Major facilitator Superfamily
CFI14_RS05545	COG0791	NLP P60 protein
CFI14_RS05550	COG1522	sequence-specific DNA binding
CFI14_RS05565	COG5001	Diguanylate cyclase
CFI14_RS05565	COG3300	MHYT domain
CFI14_RS05570	COG0488	(ABC) transporter
CFI14_RS05585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS05585	COG2190	(PTS) system
CFI14_RS05585	COG1263	PTS System
CFI14_RS05595	COG1307	EDD domain protein, DegV family
CFI14_RS05605	COG2873	o-acetylhomoserine
CFI14_RS05610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CFI14_RS05630	COG4120	Belongs to the binding-protein-dependent transport system permease family
CFI14_RS05640	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS05645	COG2084	Dehydrogenase
CFI14_RS05650	COG0861	Integral membrane protein TerC family
CFI14_RS05655	COG1902	pentaerythritol trinitrate reductase activity
CFI14_RS05685	COG0789	Transcriptional regulator
CFI14_RS05695	COG4221	oxidoreductase activity
CFI14_RS05720	COG0110	maltose O-acetyltransferase activity
CFI14_RS05725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFI14_RS05730	COG0140	phosphoribosyl-ATP diphosphatase activity
CFI14_RS05735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFI14_RS05740	COG0107	imidazoleglycerol-phosphate synthase activity
CFI14_RS05745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFI14_RS05750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFI14_RS05755	COG0131	Imidazoleglycerol-phosphate dehydratase
CFI14_RS05760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFI14_RS05765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFI14_RS05770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFI14_RS05775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFI14_RS05800	COG0300	oxidoreductase activity
CFI14_RS05810	COG1132	(ABC) transporter
CFI14_RS05815	COG1132	(ABC) transporter
CFI14_RS05840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFI14_RS05865	COG3548	integral membrane protein
CFI14_RS05885	COG0454	-acetyltransferase
CFI14_RS05890	COG1368	sulfuric ester hydrolase activity
CFI14_RS05895	COG0584	glycerophosphoryl diester phosphodiesterase
CFI14_RS05900	COG0492	ferredoxin-NADP+ reductase activity
CFI14_RS05915	COG2326	polyphosphate kinase activity
CFI14_RS05920	COG0778	Nitroreductase
CFI14_RS05945	COG0328	RNA-DNA hybrid ribonuclease activity
CFI14_RS05950	COG0561	phosphatase activity
CFI14_RS05955	COG1609	Transcriptional regulator
CFI14_RS05960	COG1737	Transcriptional regulator
CFI14_RS05965	COG0673	inositol 2-dehydrogenase activity
CFI14_RS05970	COG0673	inositol 2-dehydrogenase activity
CFI14_RS05975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFI14_RS05985	COG1335	isochorismatase
CFI14_RS05995	COG1137	ATPase activity
CFI14_RS06000	COG2186	Transcriptional regulator
CFI14_RS06055	COG0028	Belongs to the TPP enzyme family
CFI14_RS06065	COG1073	alpha beta
CFI14_RS06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFI14_RS06075	COG0626	cystathionine gamma-synthase activity
CFI14_RS06105	COG0789	Transcriptional regulator
CFI14_RS06125	COG0095	Lipoate-protein ligase
CFI14_RS06130	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFI14_RS06140	COG0564	pseudouridine synthase activity
CFI14_RS06160	COG1396	sequence-specific DNA binding
CFI14_RS06170	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS06180	COG2188	Transcriptional regulator
CFI14_RS06185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFI14_RS06200	COG1418	mRNA catabolic process
CFI14_RS06240	COG1253	flavin adenine dinucleotide binding
CFI14_RS06245	COG1780	Probably involved in ribonucleotide reductase function
CFI14_RS06255	COG2814	Major facilitator Superfamily
CFI14_RS06265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFI14_RS06275	COG0436	Aminotransferase
CFI14_RS06280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFI14_RS06295	COG0583	DNA-binding transcription factor activity
CFI14_RS06300	COG0702	epimerase
CFI14_RS06315	COG3408	Glycogen debranching enzyme
CFI14_RS06335	COG1074	ATP-dependent DNA helicase activity
CFI14_RS06340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CFI14_RS06355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFI14_RS06360	COG0284	orotidine-5'-phosphate decarboxylase activity
CFI14_RS06365	COG0167	dihydroorotate dehydrogenase activity
CFI14_RS06370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFI14_RS06375	COG0505	Belongs to the CarA family
CFI14_RS06380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFI14_RS06385	COG0540	Belongs to the ATCase OTCase family
CFI14_RS06390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFI14_RS06400	COG2508	Transcriptional regulator
CFI14_RS06405	COG2233	PERMEase
CFI14_RS06410	COG2252	PERMEase
CFI14_RS06425	COG0151	Belongs to the GarS family
CFI14_RS06430	COG0138	bifunctional purine biosynthesis protein purh
CFI14_RS06435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFI14_RS06440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFI14_RS06450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFI14_RS06455	COG0047	phosphoribosylformylglycinamidine synthase activity
CFI14_RS06460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFI14_RS06465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFI14_RS06470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFI14_RS06475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFI14_RS06480	COG1053	succinate dehydrogenase
CFI14_RS06480	COG0431	NADPH-dependent FMN reductase
CFI14_RS06480	COG3976	FMN-binding domain protein
CFI14_RS06490	COG0095	Lipoate-protein ligase
CFI14_RS06495	COG2365	Tyrosine phosphatase family
CFI14_RS06500	COG3338	carbonate dehydratase activity
CFI14_RS06520	COG1136	(ABC) transporter
CFI14_RS06535	COG1725	Transcriptional regulator
CFI14_RS06540	COG1131	(ABC) transporter
CFI14_RS06550	COG0589	response to stress
CFI14_RS06565	COG2246	polysaccharide biosynthetic process
CFI14_RS06585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFI14_RS06605	COG0366	Alpha amylase catalytic
CFI14_RS06615	COG0561	phosphatase activity
CFI14_RS06625	COG0110	maltose O-acetyltransferase activity
CFI14_RS06630	COG0494	nUDIX hydrolase
CFI14_RS06665	COG1942	4-Oxalocrotonate Tautomerase
CFI14_RS06670	COG1827	regulation of RNA biosynthetic process
CFI14_RS06675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFI14_RS06690	COG1309	transcriptional regulator
CFI14_RS06710	COG3732	PTS system glucitol sorbitol-specific
CFI14_RS06715	COG3730	PTS system glucitol sorbitol-specific
CFI14_RS06735	COG3048	D-serine ammonia-lyase activity
CFI14_RS06745	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS06750	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS06755	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFI14_RS06760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS06765	COG2188	Transcriptional regulator
CFI14_RS06770	COG1216	Glycosyl transferase, family 2
CFI14_RS06800	COG0561	phosphatase activity
CFI14_RS06805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFI14_RS06830	COG0716	FMN binding
CFI14_RS06855	COG0531	amino acid
CFI14_RS06865	COG0656	L-ascorbic acid biosynthetic process
CFI14_RS06875	COG0583	DNA-binding transcription factor activity
CFI14_RS06900	COG4720	Psort location CytoplasmicMembrane, score
CFI14_RS06905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFI14_RS06920	COG4990	cell redox homeostasis
CFI14_RS06940	COG1811	Na channel or pump
CFI14_RS06955	COG0577	efflux transmembrane transporter activity
CFI14_RS06960	COG1136	(ABC) transporter
CFI14_RS07000	COG2814	Major facilitator Superfamily
CFI14_RS07005	COG2814	Major facilitator Superfamily
CFI14_RS07015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFI14_RS07020	COG2855	membrane
CFI14_RS07025	COG0583	DNA-binding transcription factor activity
CFI14_RS07040	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS07055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFI14_RS07060	COG4152	abc transporter atp-binding protein
CFI14_RS07090	COG4221	oxidoreductase activity
CFI14_RS07105	COG0789	Transcriptional regulator
CFI14_RS07115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFI14_RS07145	COG0681	Belongs to the peptidase S26 family
CFI14_RS07160	COG0456	acetyltransferase
CFI14_RS07185	COG0589	response to stress
CFI14_RS07190	COG0110	maltose O-acetyltransferase activity
CFI14_RS07195	COG1011	Hydrolase
CFI14_RS07205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFI14_RS07210	COG1132	(ABC) transporter
CFI14_RS07215	COG1132	(ABC) transporter
CFI14_RS07220	COG2814	Major facilitator Superfamily
CFI14_RS07230	COG1511	domain protein
CFI14_RS07230	COG1511	domain protein
CFI14_RS07240	COG0640	Transcriptional regulator
CFI14_RS07265	COG0488	(ABC) transporter
CFI14_RS07270	COG0561	phosphatase activity
CFI14_RS07280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFI14_RS07300	COG2267	carboxylic ester hydrolase activity
CFI14_RS07305	COG0531	amino acid
CFI14_RS07310	COG2270	Major facilitator Superfamily
CFI14_RS07350	COG3300	MHYT domain
CFI14_RS07350	COG5001	Diguanylate cyclase
CFI14_RS07355	COG0602	queuosine metabolic process
CFI14_RS07360	COG1328	CTP reductase activity
CFI14_RS07370	COG0242	peptide deformylase activity
CFI14_RS07380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFI14_RS07400	COG0583	DNA-binding transcription factor activity
CFI14_RS07410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFI14_RS07445	COG4932	domain protein
CFI14_RS07450	COG0697	spore germination
CFI14_RS07455	COG2755	lipolytic protein G-D-S-L family
CFI14_RS07455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFI14_RS07475	COG1132	(ABC) transporter
CFI14_RS07485	COG0778	Nitroreductase
CFI14_RS07490	COG1263	PTS System
CFI14_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS07490	COG2190	(PTS) system
CFI14_RS07495	COG1116	anion transmembrane transporter activity
CFI14_RS07500	COG4120	Belongs to the binding-protein-dependent transport system permease family
CFI14_RS07535	COG0517	IMP dehydrogenase activity
CFI14_RS07540	COG0410	ABC transporter
CFI14_RS07570	COG5549	protein import
CFI14_RS07570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFI14_RS07590	COG1914	H( )-stimulated, divalent metal cation uptake system
CFI14_RS07610	COG0640	Transcriptional regulator
CFI14_RS07620	COG0577	efflux transmembrane transporter activity
CFI14_RS07620	COG1136	(ABC) transporter
CFI14_RS07655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS07660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS07665	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS07675	COG0789	Transcriptional regulator
CFI14_RS07680	COG0741	lytic transglycosylase activity
CFI14_RS07685	COG0741	lytic transglycosylase activity
CFI14_RS07715	COG3706	GGDEF domain
CFI14_RS07725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFI14_RS07740	COG1132	(ABC) transporter
CFI14_RS07745	COG1132	(ABC) transporter
CFI14_RS07750	COG1473	amidohydrolase
CFI14_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS07775	COG0531	amino acid
CFI14_RS07795	COG2217	Heavy metal translocating P-type atpase
CFI14_RS07890	COG1733	regulation of RNA biosynthetic process
CFI14_RS07895	COG2814	Major facilitator Superfamily
CFI14_RS07900	COG1376	ErfK ybiS ycfS ynhG family protein
CFI14_RS07905	COG0367	asparagine synthase
CFI14_RS07920	COG1309	transcriptional regulator
CFI14_RS07925	COG1090	epimerase
CFI14_RS07930	COG1012	belongs to the aldehyde dehydrogenase family
CFI14_RS07955	COG1733	regulation of RNA biosynthetic process
CFI14_RS07960	COG4221	oxidoreductase activity
CFI14_RS07975	COG4989	oxidoreductase activity
CFI14_RS07995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFI14_RS08000	COG1120	ATPase activity
CFI14_RS08005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFI14_RS08010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFI14_RS08015	COG0640	Transcriptional regulator
CFI14_RS08020	COG2814	Major facilitator Superfamily
CFI14_RS08025	COG4221	oxidoreductase activity
CFI14_RS08030	COG0110	maltose O-acetyltransferase activity
CFI14_RS08065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFI14_RS08085	COG2816	NAD+ diphosphatase activity
CFI14_RS08120	COG0789	Transcriptional regulator
CFI14_RS08140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS08145	COG3976	FMN-binding domain protein
CFI14_RS08145	COG1053	succinate dehydrogenase
CFI14_RS08145	COG0431	NADPH-dependent FMN reductase
CFI14_RS08150	COG0583	DNA-binding transcription factor activity
CFI14_RS08155	COG3711	transcriptional antiterminator
CFI14_RS08160	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS08165	COG1263	PTS System
CFI14_RS08165	COG2190	(PTS) system
CFI14_RS08195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CFI14_RS08205	COG0583	DNA-binding transcription factor activity
CFI14_RS08215	COG0300	oxidoreductase activity
CFI14_RS08230	COG1064	alcohol dehydrogenase
CFI14_RS08235	COG0025	NhaP-type Na H and K H
CFI14_RS08255	COG0110	maltose O-acetyltransferase activity
CFI14_RS08260	COG4975	Glucose uptake
CFI14_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS08275	COG1940	carbohydrate kinase activity
CFI14_RS08290	COG0583	DNA-binding transcription factor activity
CFI14_RS08295	COG1053	succinate dehydrogenase
CFI14_RS08305	COG2226	methyltransferase
CFI14_RS08310	COG0588	phosphoglycerate mutase activity
CFI14_RS08315	COG0628	permease
CFI14_RS08320	COG1940	carbohydrate kinase activity
CFI14_RS08320	COG1846	Transcriptional regulator
CFI14_RS08330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFI14_RS08340	COG2815	serine threonine protein kinase
CFI14_RS08340	COG0515	serine threonine protein kinase
CFI14_RS08375	COG1247	-acetyltransferase
CFI14_RS08390	COG1686	Belongs to the peptidase S11 family
CFI14_RS08405	COG0516	GMP reductase activity
CFI14_RS08405	COG0517	IMP dehydrogenase activity
CFI14_RS08415	COG0012	GTP binding
CFI14_RS08420	COG4481	Protein conserved in bacteria
CFI14_RS08425	COG1475	DNA binding
CFI14_RS08430	COG1192	Involved in chromosome partitioning
CFI14_RS08440	COG0357	Ribosomal RNA small subunit methyltransferase G
CFI14_RS08450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFI14_RS08460	COG0463	Glycosyl transferase, family 2
CFI14_RS08475	COG0583	DNA-binding transcription factor activity
CFI14_RS08480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFI14_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFI14_RS08495	COG0765	amino acid transport
CFI14_RS08500	COG1126	abc transporter atp-binding protein
CFI14_RS08505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFI14_RS08520	COG1131	(ABC) transporter
CFI14_RS08565	COG1373	ATPase (AAA superfamily
CFI14_RS08575	COG0481	GTPase activity
CFI14_RS08585	COG0390	transport system, permease component
CFI14_RS08590	COG4619	ABC transporter
CFI14_RS08595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFI14_RS08610	COG0561	phosphatase activity
CFI14_RS08625	COG1263	PTS System
CFI14_RS08625	COG2190	(PTS) system
CFI14_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS08655	COG0735	belongs to the Fur family
CFI14_RS08675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFI14_RS08680	COG1380	Effector of murein hydrolase LrgA
CFI14_RS08690	COG1307	EDD domain protein, DegV family
CFI14_RS08700	COG2738	Putative neutral zinc metallopeptidase
CFI14_RS08715	COG1929	Belongs to the glycerate kinase type-1 family
CFI14_RS08730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFI14_RS08735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFI14_RS08740	COG0516	GMP reductase activity
CFI14_RS08750	COG0444	Belongs to the ABC transporter superfamily
CFI14_RS08755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFI14_RS08760	COG0601	transmembrane transport
CFI14_RS08765	COG4166	transmembrane transport
CFI14_RS08770	COG2365	Tyrosine phosphatase family
CFI14_RS08775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFI14_RS08785	COG0531	amino acid
CFI14_RS08790	COG3158	transport of potassium into the cell
CFI14_RS08800	COG0628	permease
CFI14_RS08805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFI14_RS08820	COG1272	protein, Hemolysin III
CFI14_RS08825	COG0640	Transcriptional regulator
CFI14_RS08840	COG0519	Catalyzes the synthesis of GMP from XMP
CFI14_RS08850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFI14_RS08860	COG0302	gtp cyclohydrolase
CFI14_RS08865	COG0302	gtp cyclohydrolase
CFI14_RS08865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFI14_RS08885	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFI14_RS08890	COG2814	Major facilitator Superfamily
CFI14_RS08925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFI14_RS08935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFI14_RS08940	COG2151	metal-sulfur cluster biosynthetic enzyme
CFI14_RS08950	COG1396	sequence-specific DNA binding
CFI14_RS08955	COG0477	Major facilitator Superfamily
CFI14_RS08960	COG4989	oxidoreductase activity
CFI14_RS08990	COG2217	Heavy metal translocating P-type atpase
CFI14_RS09005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CFI14_RS09010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFI14_RS09020	COG1757	Na H antiporter
CFI14_RS09025	COG1113	amino acid transport
CFI14_RS09035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFI14_RS09050	COG1393	Belongs to the ArsC family
CFI14_RS09055	COG3189	MarR family transcriptional regulator
CFI14_RS09065	COG2801	Transposase and inactivated derivatives
CFI14_RS09075	COG1194	a g-specific adenine glycosylase
CFI14_RS09110	COG0697	spore germination
CFI14_RS09125	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CFI14_RS09135	COG3682	Transcriptional regulator
CFI14_RS09150	COG0477	Major facilitator Superfamily
CFI14_RS09205	COG0737	Belongs to the 5'-nucleotidase family
CFI14_RS09210	COG0679	Auxin Efflux Carrier
CFI14_RS09220	COG0656	L-ascorbic acid biosynthetic process
CFI14_RS09245	COG1968	undecaprenyl-diphosphatase activity
CFI14_RS09250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CFI14_RS09295	COG3103	Sh3 type 3 domain protein
CFI14_RS09295	COG0791	NLP P60 protein
CFI14_RS09295	COG1388	LysM domain
CFI14_RS09295	COG3103	Sh3 type 3 domain protein
CFI14_RS09295	COG1388	LysM domain
CFI14_RS09295	COG0791	NLP P60 protein
CFI14_RS09345	COG2226	methyltransferase
CFI14_RS09360	COG2217	Heavy metal translocating P-type atpase
CFI14_RS09365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFI14_RS09375	COG3118	belongs to the thioredoxin family
CFI14_RS09380	COG1937	Protein conserved in bacteria
CFI14_RS09410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFI14_RS09415	COG3590	peptidase
CFI14_RS09425	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS09475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFI14_RS09500	COG1114	Component of the transport system for branched-chain amino acids
CFI14_RS09510	COG1874	Beta-galactosidase
CFI14_RS09515	COG1609	Transcriptional regulator
CFI14_RS09525	COG2184	nucleotidyltransferase activity
CFI14_RS09530	COG2944	sequence-specific DNA binding
CFI14_RS09550	COG1609	Transcriptional regulator
CFI14_RS09555	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CFI14_RS09560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFI14_RS09565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CFI14_RS09585	COG2211	Major facilitator Superfamily
CFI14_RS09585	COG2190	(PTS) system
CFI14_RS09590	COG2017	converts alpha-aldose to the beta-anomer
CFI14_RS09595	COG1609	Transcriptional regulator
CFI14_RS09600	COG0667	Aldo Keto reductase
CFI14_RS09620	COG0710	3-dehydroquinate dehydratase activity
CFI14_RS09625	COG0738	Major facilitator superfamily
CFI14_RS09630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFI14_RS09635	COG0583	DNA-binding transcription factor activity
CFI14_RS09640	COG0738	Major facilitator superfamily
CFI14_RS09645	COG2190	(PTS) system
CFI14_RS09645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS09645	COG1263	PTS System
CFI14_RS09650	COG1737	Transcriptional regulator
CFI14_RS09655	COG1263	PTS System
CFI14_RS09655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS09660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFI14_RS09680	COG0318	PFAM AMP-dependent synthetase and ligase
CFI14_RS09685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFI14_RS09695	COG1960	acyl-CoA dehydrogenase activity
CFI14_RS09710	COG2223	nitrite transmembrane transporter activity
CFI14_RS09715	COG0583	DNA-binding transcription factor activity
CFI14_RS09720	COG1929	Belongs to the glycerate kinase type-1 family
CFI14_RS09725	COG0383	alpha-mannosidase activity
CFI14_RS09730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS09730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09740	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS09745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS09750	COG1940	carbohydrate kinase activity
CFI14_RS09750	COG1846	Transcriptional regulator
CFI14_RS09760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFI14_RS09765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS09770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09780	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS09785	COG1263	PTS System
CFI14_RS09785	COG2190	(PTS) system
CFI14_RS09785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS09820	COG1940	carbohydrate kinase activity
CFI14_RS09825	COG1609	Transcriptional regulator
CFI14_RS09830	COG2211	Major facilitator Superfamily
CFI14_RS09850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFI14_RS09865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFI14_RS09880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS09880	COG3711	transcriptional antiterminator
CFI14_RS09885	COG0546	phosphoglycolate phosphatase activity
CFI14_RS09895	COG1063	alcohol dehydrogenase
CFI14_RS09900	COG3775	system Galactitol-specific IIC component
CFI14_RS09905	COG3414	Phosphotransferase system galactitol-specific IIB component
CFI14_RS09915	COG1349	DNA-binding transcription factor activity
CFI14_RS09920	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CFI14_RS09930	COG0110	maltose O-acetyltransferase activity
CFI14_RS09935	COG2160	L-arabinose isomerase activity
CFI14_RS09955	COG1609	Transcriptional regulator
CFI14_RS09960	COG1737	Transcriptional regulator
CFI14_RS09980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFI14_RS10000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFI14_RS10005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CFI14_RS10030	COG0235	Class ii aldolase
CFI14_RS10035	COG4806	L-rhamnose isomerase
CFI14_RS10040	COG3254	rhamnose metabolic process
CFI14_RS10045	COG1070	Carbohydrate kinase
CFI14_RS10050	COG2814	Major facilitator Superfamily
CFI14_RS10055	COG2207	Transcriptional regulator
CFI14_RS10060	COG1349	DNA-binding transcription factor activity
CFI14_RS10090	COG1070	Carbohydrate kinase
CFI14_RS10105	COG2190	(PTS) system
CFI14_RS10105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS10105	COG1263	PTS System
CFI14_RS10125	COG1737	Transcriptional regulator
CFI14_RS10130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS10130	COG1263	PTS System
CFI14_RS10150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS10150	COG1263	PTS System
CFI14_RS10175	COG1609	Transcriptional regulator
CFI14_RS10185	COG0366	Alpha amylase catalytic
CFI14_RS10190	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS10195	COG1940	carbohydrate kinase activity
CFI14_RS10200	COG0383	alpha-mannosidase activity
CFI14_RS10210	COG1609	Transcriptional regulator
CFI14_RS10225	COG3842	ATPase activity
CFI14_RS10235	COG2207	Transcriptional regulator
CFI14_RS10235	COG4753	response regulator
CFI14_RS10240	COG2972	Histidine kinase
CFI14_RS10250	COG0366	Alpha amylase catalytic
CFI14_RS10255	COG1653	transport
CFI14_RS10260	COG0395	ABC-type sugar transport system, permease component
CFI14_RS10275	COG2207	Transcriptional regulator
CFI14_RS10275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFI14_RS10280	COG1132	(ABC) transporter
CFI14_RS10285	COG1132	(ABC) transporter
CFI14_RS10290	COG1609	Transcriptional regulator
CFI14_RS10305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS10320	COG0671	phosphoesterase, PA-phosphatase related
CFI14_RS10325	COG4975	Glucose uptake
CFI14_RS10330	COG1869	D-ribose catabolic process
CFI14_RS10340	COG1609	Transcriptional regulator
CFI14_RS10375	COG1012	belongs to the aldehyde dehydrogenase family
CFI14_RS10375	COG1454	alcohol dehydrogenase
CFI14_RS10385	COG1695	Transcriptional regulator
CFI14_RS10390	COG3479	Phenolic acid decarboxylase
CFI14_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS10420	COG2946	Replication initiation factor
CFI14_RS10435	COG1307	EDD domain protein, DegV family
CFI14_RS10450	COG0681	Belongs to the peptidase S26 family
CFI14_RS10455	COG0445	tRNA wobble uridine modification
CFI14_RS10460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFI14_RS10475	COG4166	transmembrane transport
CFI14_RS10480	COG0706	membrane insertase activity
CFI14_RS10485	COG0594	ribonuclease P activity
CFI14_RS10490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFI14_RS10495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFI14_RS10500	COG0592	DNA-directed DNA polymerase activity
CFI14_RS10505	COG2501	S4 domain
CFI14_RS10510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFI14_RS10515	COG0187	DNA topoisomerase II activity
CFI14_RS10530	COG0360	Binds together with S18 to 16S ribosomal RNA
CFI14_RS10535	COG0629	single-stranded DNA binding
CFI14_RS10540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFI14_RS10550	COG0359	binds to the 23S rRNA
CFI14_RS10555	COG0305	Participates in initiation and elongation during chromosome replication
CFI14_RS10560	COG2814	Major facilitator Superfamily
CFI14_RS10565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFI14_RS10570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFI14_RS10580	COG4166	transmembrane transport
CFI14_RS10585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFI14_RS10590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFI14_RS10595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFI14_RS10600	COG0297	glycogen (starch) synthase activity
CFI14_RS10605	COG0058	SHG alpha-glucan phosphorylase activity
CFI14_RS10615	COG0561	phosphatase activity
CFI14_RS10620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFI14_RS10625	COG1554	hydrolase, family 65, central catalytic
CFI14_RS10635	COG1278	Cold shock
CFI14_RS10720	COG4695	Portal protein
CFI14_RS10750	COG0745	RESPONSE REGULATOR receiver
CFI14_RS10755	COG5002	protein histidine kinase activity
CFI14_RS10765	COG4853	Protein conserved in bacteria
CFI14_RS10770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFI14_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFI14_RS10780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFI14_RS10785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFI14_RS10815	COG2814	Major facilitator Superfamily
CFI14_RS10820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFI14_RS10825	COG1846	Transcriptional regulator
CFI14_RS10835	COG1132	(ABC) transporter
CFI14_RS10845	COG1573	uracil-dna glycosylase
CFI14_RS10870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFI14_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS10885	COG0778	Nitroreductase
CFI14_RS10890	COG2508	Transcriptional regulator
CFI14_RS10895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFI14_RS10905	COG0540	Belongs to the ATCase OTCase family
CFI14_RS10930	COG1396	sequence-specific DNA binding
CFI14_RS10940	COG2365	Tyrosine phosphatase family
CFI14_RS10945	COG2368	4-hydroxyphenylacetate
CFI14_RS10950	COG2814	Major facilitator Superfamily
CFI14_RS10975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFI14_RS10995	COG3321	synthase
CFI14_RS10995	COG0604	alcohol dehydrogenase
CFI14_RS11010	COG2267	carboxylic ester hydrolase activity
CFI14_RS11015	COG3022	response to hydroperoxide
CFI14_RS11040	COG4166	transmembrane transport
CFI14_RS11060	COG1122	ATPase activity
CFI14_RS11065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFI14_RS11070	COG0310	cobalt ion transport
CFI14_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFI14_RS11080	COG3875	lactate racemase activity
CFI14_RS11085	COG1691	(AIR) carboxylase
CFI14_RS11090	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CFI14_RS11095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFI14_RS11100	COG1606	tRNA processing
CFI14_RS11110	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFI14_RS11115	COG0351	phosphomethylpyrimidine kinase
CFI14_RS11120	COG0352	thiamine-phosphate diphosphorylase activity
CFI14_RS11130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFI14_RS11135	COG0604	alcohol dehydrogenase
CFI14_RS11140	COG1733	regulation of RNA biosynthetic process
CFI14_RS11155	COG1113	amino acid transport
CFI14_RS11170	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CFI14_RS11175	COG1518	maintenance of DNA repeat elements
CFI14_RS11190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFI14_RS11195	COG1983	PspC domain protein
CFI14_RS11220	COG0640	Transcriptional regulator
CFI14_RS11225	COG2807	transmembrane transport
CFI14_RS11230	COG0656	L-ascorbic acid biosynthetic process
CFI14_RS11235	COG0667	Aldo Keto reductase
CFI14_RS11280	COG1733	regulation of RNA biosynthetic process
CFI14_RS11285	COG2814	Major facilitator Superfamily
CFI14_RS11290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFI14_RS11295	COG1122	ATPase activity
CFI14_RS11300	COG4720	Psort location CytoplasmicMembrane, score
CFI14_RS11310	COG2188	Transcriptional regulator
CFI14_RS11335	COG1131	(ABC) transporter
CFI14_RS11350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFI14_RS11355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CFI14_RS11360	COG1309	transcriptional regulator
CFI14_RS11365	COG2376	Dihydroxyacetone kinase
CFI14_RS11370	COG2376	Dihydroxyacetone kinase
CFI14_RS11375	COG1461	Dihydroxyacetone kinase
CFI14_RS11380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CFI14_RS11395	COG1609	Transcriptional regulator
CFI14_RS11400	COG1609	Transcriptional regulator
CFI14_RS11405	COG0366	Alpha amylase catalytic
CFI14_RS11410	COG0366	Alpha amylase catalytic
CFI14_RS11435	COG3842	ATPase activity
CFI14_RS11485	COG1063	alcohol dehydrogenase
CFI14_RS11490	COG1757	Na H antiporter
CFI14_RS11510	COG4166	transmembrane transport
CFI14_RS11515	COG4166	transmembrane transport
CFI14_RS11520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFI14_RS11525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CFI14_RS11530	COG0406	alpha-ribazole phosphatase activity
CFI14_RS11535	COG1132	(ABC) transporter
CFI14_RS11545	COG0667	Aldo Keto reductase
CFI14_RS11575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFI14_RS11580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFI14_RS11585	COG0488	(ABC) transporter
CFI14_RS11595	COG1122	ATPase activity
CFI14_RS11605	COG0386	Belongs to the glutathione peroxidase family
CFI14_RS11625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFI14_RS11645	COG0363	glucosamine-6-phosphate deaminase activity
CFI14_RS11675	COG2213	PTS system mannitol-specific
CFI14_RS11685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS11690	COG0246	Mannitol dehydrogenase
CFI14_RS11700	COG3118	belongs to the thioredoxin family
CFI14_RS11740	COG0431	NADPH-dependent FMN reductase
CFI14_RS11745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS11760	COG1045	serine acetyltransferase
CFI14_RS11765	COG0626	cystathionine gamma-synthase activity
CFI14_RS11770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFI14_RS11775	COG1131	(ABC) transporter
CFI14_RS11805	COG2188	Transcriptional regulator
CFI14_RS11810	COG0366	Alpha amylase catalytic
CFI14_RS11815	COG2190	(PTS) system
CFI14_RS11815	COG1263	PTS System
CFI14_RS11815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS11820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS11820	COG2190	(PTS) system
CFI14_RS11820	COG1263	PTS System
CFI14_RS11830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFI14_RS11835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFI14_RS11840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFI14_RS11845	COG0463	Glycosyl transferase, family 2
CFI14_RS11845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFI14_RS11855	COG0163	prenyltransferase activity
CFI14_RS11870	COG1959	2 iron, 2 sulfur cluster binding
CFI14_RS11875	COG1309	transcriptional regulator
CFI14_RS11880	COG1914	H( )-stimulated, divalent metal cation uptake system
CFI14_RS11900	COG5002	protein histidine kinase activity
CFI14_RS11905	COG0745	RESPONSE REGULATOR receiver
CFI14_RS11915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CFI14_RS11915	COG0517	IMP dehydrogenase activity
CFI14_RS11920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS11955	COG0277	FAD linked oxidase domain protein
CFI14_RS11965	COG2357	RelA SpoT domain protein
CFI14_RS11975	COG1033	growth of symbiont in host cell
CFI14_RS11975	COG2409	Drug exporters of the RND superfamily
CFI14_RS11975	COG1033	growth of symbiont in host cell
CFI14_RS11975	COG2409	Drug exporters of the RND superfamily
CFI14_RS11980	COG2818	Glycosylase
CFI14_RS11990	COG0577	efflux transmembrane transporter activity
CFI14_RS11995	COG1136	(ABC) transporter
CFI14_RS12005	COG0741	lytic transglycosylase activity
CFI14_RS12050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFI14_RS12060	COG1846	Transcriptional regulator
CFI14_RS12065	COG1252	NADH dehydrogenase
CFI14_RS12110	COG3842	ATPase activity
CFI14_RS12145	COG1725	Transcriptional regulator
CFI14_RS12150	COG1131	(ABC) transporter
CFI14_RS12160	COG1454	alcohol dehydrogenase
CFI14_RS12160	COG1012	belongs to the aldehyde dehydrogenase family
CFI14_RS12220	COG1132	(ABC) transporter
CFI14_RS12235	COG1268	BioY protein
CFI14_RS12250	COG1464	Belongs to the NlpA lipoprotein family
CFI14_RS12260	COG2011	ABC-type metal ion transport system permease component
CFI14_RS12265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFI14_RS12270	COG0436	Aminotransferase
CFI14_RS12285	COG1682	transport, permease protein
CFI14_RS12290	COG1134	teichoic acid transport
CFI14_RS12300	COG0004	ammonium transporteR
CFI14_RS12320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFI14_RS12330	COG3759	membrane
CFI14_RS12340	COG1881	PFAM PEBP family protein
CFI14_RS12370	COG0300	oxidoreductase activity
CFI14_RS12390	COG1125	glycine betaine transport
CFI14_RS12400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFI14_RS12410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFI14_RS12450	COG0110	maltose O-acetyltransferase activity
CFI14_RS12460	COG0561	phosphatase activity
CFI14_RS12470	COG0561	phosphatase activity
CFI14_RS12475	COG1114	Component of the transport system for branched-chain amino acids
CFI14_RS12515	COG3290	protein histidine kinase activity
CFI14_RS12520	COG3290	protein histidine kinase activity
CFI14_RS12530	COG3290	protein histidine kinase activity
CFI14_RS12535	COG3279	Response regulator of the LytR AlgR family
CFI14_RS12575	COG3973	AAA domain
CFI14_RS12580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFI14_RS12585	COG0180	Tryptophanyl-tRNA synthetase
CFI14_RS12590	COG4166	transmembrane transport
CFI14_RS12595	COG0601	transmembrane transport
CFI14_RS12600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFI14_RS12605	COG0444	Belongs to the ABC transporter superfamily
CFI14_RS12625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS12640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFI14_RS12650	COG0248	Ppx GppA phosphatase
CFI14_RS12665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFI14_RS12670	COG1801	Protein of unknown function DUF72
CFI14_RS12675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFI14_RS12675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFI14_RS12690	COG0084	hydrolase, TatD family'
CFI14_RS12695	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFI14_RS12700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFI14_RS12705	COG4466	Protein conserved in bacteria
CFI14_RS12710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFI14_RS12715	COG1073	alpha beta
CFI14_RS12720	COG1121	(ABC) transporter
CFI14_RS12725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFI14_RS12725	COG1321	iron dependent repressor
CFI14_RS12760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFI14_RS12765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFI14_RS12775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFI14_RS12795	COG1078	dGTPase activity
CFI14_RS12800	COG0095	Lipoate-protein ligase
CFI14_RS12810	COG3343	RNA polymerase activity
CFI14_RS12815	COG0504	CTP synthase activity
CFI14_RS12825	COG0655	NAD(P)H dehydrogenase (quinone) activity
CFI14_RS12835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFI14_RS12840	COG0814	amino acid
CFI14_RS12850	COG1760	l-serine dehydratase
CFI14_RS12855	COG1760	l-serine dehydratase
CFI14_RS12880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFI14_RS12885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFI14_RS12890	COG0254	rRNA binding
CFI14_RS12895	COG1132	(ABC) transporter
CFI14_RS12910	COG3764	Sortase (surface protein transpeptidase)
CFI14_RS12915	COG1704	LemA family
CFI14_RS12920	COG0501	Belongs to the peptidase M48B family
CFI14_RS12930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFI14_RS12945	COG0736	holo-[acyl-carrier-protein] synthase activity
CFI14_RS12950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFI14_RS12955	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFI14_RS12960	COG3158	transport of potassium into the cell
CFI14_RS12980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFI14_RS12985	COG0505	Belongs to the CarA family
CFI14_RS12990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFI14_RS12995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CFI14_RS13000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFI14_RS13005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFI14_RS13010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFI14_RS13045	COG0193	aminoacyl-tRNA hydrolase activity
CFI14_RS13050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFI14_RS13055	COG2244	polysaccharide biosynthetic process
CFI14_RS13060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFI14_RS13070	COG1098	S1 RNA binding domain
CFI14_RS13080	COG2801	Transposase and inactivated derivatives
CFI14_RS13090	COG0037	tRNA processing
CFI14_RS13105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFI14_RS13110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFI14_RS13115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFI14_RS13160	COG3104	oligopeptide transport
CFI14_RS13180	COG0582	viral genome integration into host DNA
CFI14_RS13250	COG0531	amino acid
CFI14_RS13295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFI14_RS13305	COG2188	Transcriptional regulator
CFI14_RS13315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFI14_RS13320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFI14_RS13345	COG2183	response to ionizing radiation
CFI14_RS13350	COG3091	SprT-like family
CFI14_RS13355	COG0460	homoserine dehydrogenase
CFI14_RS13360	COG0083	homoserine kinase activity
CFI14_RS13370	COG0582	viral genome integration into host DNA
CFI14_RS13420	COG1396	sequence-specific DNA binding
CFI14_RS13435	COG3646	Phage regulatory protein
CFI14_RS13650	COG3715	PTS system
CFI14_RS13655	COG3716	PTS system mannose fructose sorbose family IID component
CFI14_RS13665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CFI14_RS13665	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CFI14_RS13670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS13670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS13675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS13675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFI14_RS13680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFI14_RS13685	COG0509	glycine decarboxylation via glycine cleavage system
CFI14_RS13700	COG0825	malonyl-CoA metabolic process
CFI14_RS13705	COG1316	TRANSCRIPTIONal
CFI14_RS13715	COG0697	spore germination
CFI14_RS13720	COG0588	phosphoglycerate mutase activity
CFI14_RS13750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFI14_RS13760	COG0756	dUTP diphosphatase activity
CFI14_RS13770	COG4956	integral membrane protein (PIN domain superfamily)
CFI14_RS13775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFI14_RS13785	COG0215	cysteine-tRNA ligase activity
CFI14_RS13790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CFI14_RS13795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFI14_RS13810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFI14_RS13815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFI14_RS13820	COG0250	Participates in transcription elongation, termination and antitermination
CFI14_RS13830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFI14_RS13835	COG0081	regulation of translation
CFI14_RS13840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFI14_RS13845	COG0222	ribosome binding
CFI14_RS13870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CFI14_RS13870	COG0392	lysyltransferase activity
CFI14_RS13875	COG1611	Belongs to the LOG family
CFI14_RS13885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFI14_RS13890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CFI14_RS13895	COG2813	Specifically methylates the guanine in position
CFI14_RS13900	COG0590	tRNA wobble adenosine to inosine editing
CFI14_RS13910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFI14_RS13915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFI14_RS13920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFI14_RS13930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFI14_RS13935	COG3870	Protein conserved in bacteria
CFI14_RS13940	COG0470	DNA polymerase III
CFI14_RS13945	COG4467	Involved in initiation control of chromosome replication
CFI14_RS13960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFI14_RS13970	COG3639	organic phosphonate transmembrane transporter activity
CFI14_RS13980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFI14_RS13990	COG1214	PFAM Peptidase M22, glycoprotease
CFI14_RS13995	COG0456	acetyltransferase
CFI14_RS14000	COG0456	acetyltransferase
CFI14_RS14005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFI14_RS14010	COG0488	(ABC) transporter
CFI14_RS14015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFI14_RS14020	COG1266	CAAX protease self-immunity
CFI14_RS14030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFI14_RS14035	COG0459	protein refolding
CFI14_RS14040	COG0531	amino acid
CFI14_RS14045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFI14_RS14050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFI14_RS14055	COG1739	Uncharacterized protein family UPF0029
CFI14_RS14060	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CFI14_RS14065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFI14_RS14075	COG0653	protein targeting
CFI14_RS14090	COG0745	RESPONSE REGULATOR receiver
CFI14_RS14095	COG5002	protein histidine kinase activity
CFI14_RS14110	COG0573	inorganic phosphate transmembrane transporter activity
CFI14_RS14115	COG0581	inorganic phosphate transmembrane transporter activity
CFI14_RS14120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFI14_RS14125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFI14_RS14130	COG0704	Plays a role in the regulation of phosphate uptake
CFI14_RS14135	COG1983	PspC domain protein
CFI14_RS14140	COG1950	PFAM Membrane protein of
CFI14_RS14145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFI14_RS14150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFI14_RS14155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFI14_RS14160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CFI14_RS14170	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS14195	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS14210	COG0492	ferredoxin-NADP+ reductase activity
CFI14_RS14215	COG2323	membrane
CFI14_RS14225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFI14_RS14235	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFI14_RS14245	COG2814	Major facilitator Superfamily
CFI14_RS14255	COG0556	nucleotide-excision repair
CFI14_RS14260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFI14_RS14265	COG1854	S-ribosylhomocysteine lyase activity
CFI14_RS14270	COG0137	argininosuccinate synthase activity
CFI14_RS14275	COG0165	Argininosuccinate lyase
CFI14_RS14285	COG1660	Displays ATPase and GTPase activities
CFI14_RS14295	COG1481	regulation of sporulation
CFI14_RS14300	COG4166	transmembrane transport
CFI14_RS14305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFI14_RS14310	COG0740	serine-type endopeptidase activity
CFI14_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
CFI14_RS14335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CFI14_RS14340	COG2390	Transcriptional regulator
CFI14_RS14350	COG0126	phosphoglycerate kinase activity
CFI14_RS14355	COG0149	triose-phosphate isomerase activity
CFI14_RS14360	COG0148	phosphopyruvate hydratase activity
CFI14_RS14375	COG0038	chloride channel
CFI14_RS14380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFI14_RS14395	COG0557	exoribonuclease II activity
CFI14_RS14400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFI14_RS14410	COG0765	amino acid transport
CFI14_RS14415	COG1126	abc transporter atp-binding protein
CFI14_RS14435	COG0561	phosphatase activity
CFI14_RS14440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFI14_RS14445	COG0280	phosphate acetyltransferase
CFI14_RS14450	COG0802	atpase or kinase
CFI14_RS14460	COG2176	DNA-directed DNA polymerase activity
CFI14_RS14465	COG0708	Exodeoxyribonuclease III
CFI14_RS14475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFI14_RS14480	COG0025	NhaP-type Na H and K H
CFI14_RS14505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFI14_RS14510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFI14_RS14515	COG0561	phosphatase activity
CFI14_RS14530	COG2801	Transposase and inactivated derivatives
CFI14_RS14550	COG0778	Nitroreductase
CFI14_RS14560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFI14_RS14575	COG1393	Belongs to the ArsC family
CFI14_RS14590	COG0477	Major facilitator Superfamily
CFI14_RS14595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFI14_RS14595	COG0248	Ppx GppA phosphatase
CFI14_RS14600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFI14_RS14610	COG3475	LICD family
CFI14_RS14625	COG2252	PERMEase
CFI14_RS14630	COG0028	Belongs to the TPP enzyme family
CFI14_RS14635	COG0196	riboflavin kinase activity
CFI14_RS14640	COG0028	Belongs to the TPP enzyme family
CFI14_RS14645	COG2267	carboxylic ester hydrolase activity
CFI14_RS14655	COG2755	lipolytic protein G-D-S-L family
CFI14_RS14655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFI14_RS14660	COG2936	dipeptidyl-peptidase activity
CFI14_RS14675	COG0531	amino acid
CFI14_RS14700	COG0194	GDP metabolic process
CFI14_RS14705	COG0735	belongs to the Fur family
CFI14_RS14720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFI14_RS14730	COG0436	Aminotransferase
CFI14_RS14735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFI14_RS14750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFI14_RS14755	COG0765	amino acid transport
CFI14_RS14760	COG0765	amino acid transport
CFI14_RS14775	COG1263	PTS System
CFI14_RS14775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS14780	COG3394	polysaccharide catabolic process
CFI14_RS14785	COG0531	amino acid
CFI14_RS14815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFI14_RS14830	COG2076	Multidrug Resistance protein
CFI14_RS14840	COG0406	alpha-ribazole phosphatase activity
CFI14_RS14845	COG0588	phosphoglycerate mutase activity
CFI14_RS14850	COG0569	domain protein
CFI14_RS14850	COG0475	glutathione-regulated potassium exporter activity
CFI14_RS14855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFI14_RS14860	COG0586	Pfam SNARE associated Golgi protein
CFI14_RS14865	COG3973	AAA domain
CFI14_RS14870	COG2070	2-Nitropropane dioxygenase
CFI14_RS14875	COG1737	Transcriptional regulator
CFI14_RS14880	COG1263	PTS System
CFI14_RS14880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFI14_RS14880	COG2190	(PTS) system
CFI14_RS14885	COG2723	6-phospho-beta-galactosidase activity
CFI14_RS14890	COG1072	(Pantothenic acid kinase))
CFI14_RS14895	COG0519	Catalyzes the synthesis of GMP from XMP
CFI14_RS14895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFI14_RS14925	COG0464	growth
CFI14_RS14935	COG1266	CAAX protease self-immunity
CFI14_RS14955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFI14_RS14955	COG2755	lipolytic protein G-D-S-L family
CFI14_RS14960	COG2261	transglycosylase associated protein
CFI14_RS14975	COG1302	Protein conserved in bacteria
CFI14_RS15020	COG0583	DNA-binding transcription factor activity
CFI14_RS15025	COG1053	succinate dehydrogenase
CFI14_RS15040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFI14_RS15050	COG2502	aspartate--ammonia ligase
CFI14_RS15055	COG4690	dipeptidase activity
CFI14_RS15075	COG0514	ATP-dependent DNA helicase (RecQ)
CFI14_RS15080	COG0564	pseudouridine synthase activity
CFI14_RS15085	COG0640	Transcriptional regulator
CFI14_RS15135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFI14_RS15140	COG0527	aspartate kinase activity
CFI14_RS15145	COG0367	asparagine synthase
CFI14_RS15185	COG2814	Major facilitator Superfamily
CFI14_RS15205	COG1278	Cold shock
CFI14_RS15215	COG2966	Psort location CytoplasmicMembrane, score
CFI14_RS15230	COG1316	TRANSCRIPTIONal
CFI14_RS15250	COG1959	2 iron, 2 sulfur cluster binding
CFI14_RS15255	COG0028	Belongs to the TPP enzyme family
CFI14_RS15260	COG0833	amino acid
CFI14_RS15270	COG1428	Deoxynucleoside kinase
CFI14_RS15275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFI14_RS15320	COG4463	regulation of RNA biosynthetic process
CFI14_RS15325	COG0542	response to heat
CFI14_RS15335	COG0085	RNA polymerase activity
CFI14_RS15340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFI14_RS15345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFI14_RS15350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFI14_RS15355	COG0049	tRNA binding
CFI14_RS15360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFI14_RS15370	COG0051	transcription antitermination factor activity, RNA binding
CFI14_RS15375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFI14_RS15380	COG0088	Forms part of the polypeptide exit tunnel
CFI14_RS15385	COG0089	rRNA binding
CFI14_RS15390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFI14_RS15395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFI14_RS15400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFI14_RS15405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFI14_RS15410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFI14_RS15415	COG0255	Belongs to the universal ribosomal protein uL29 family
CFI14_RS15420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFI14_RS15425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFI14_RS15430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFI14_RS15435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFI14_RS15440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFI14_RS15445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFI14_RS15450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFI14_RS15455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFI14_RS15460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFI14_RS15465	COG1841	ribosomal large subunit assembly
CFI14_RS15470	COG0200	Binds to the 23S rRNA
CFI14_RS15480	COG0563	adenylate kinase activity
CFI14_RS15485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFI14_RS15490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFI14_RS15495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFI14_RS15500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFI14_RS15505	COG0202	RNA polymerase activity
CFI14_RS15510	COG0203	ribosomal protein L17
CFI14_RS15535	COG4939	FMN-binding domain protein
CFI14_RS15545	COG1122	ATPase activity
CFI14_RS15550	COG1122	ATPase activity
CFI14_RS15560	COG0101	tRNA pseudouridine synthase activity
CFI14_RS15565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFI14_RS15570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFI14_RS15600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFI14_RS15605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFI14_RS15610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFI14_RS15615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFI14_RS15620	COG0471	metal ion transport
CFI14_RS15625	COG2151	metal-sulfur cluster biosynthetic enzyme
CFI14_RS15630	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CFI14_RS15640	COG1917	Cupin 2, conserved barrel domain protein
CFI14_RS15640	COG4977	sequence-specific DNA binding
CFI14_RS15645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CFI14_RS15650	COG1121	(ABC) transporter
CFI14_RS15655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFI14_RS15680	COG0039	L-malate dehydrogenase activity
CFI14_RS15685	COG0471	metal ion transport
CFI14_RS15705	COG3052	prosthetic group binding
CFI14_RS15730	COG0114	fumarate hydratase activity
CFI14_RS15735	COG1053	succinate dehydrogenase
CFI14_RS15745	COG0583	DNA-binding transcription factor activity
CFI14_RS15755	COG2801	Transposase and inactivated derivatives
CFI14_RS15765	COG0583	DNA-binding transcription factor activity
CFI14_RS15770	COG0281	malic enzyme
CFI14_RS15780	COG0531	amino acid
CFI14_RS15785	COG4684	Psort location CytoplasmicMembrane, score
CFI14_RS15800	COG1271	oxidase subunit
CFI14_RS15805	COG1294	oxidase, subunit
CFI14_RS15810	COG4988	ABC transporter
CFI14_RS15815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFI14_RS15825	COG0142	geranyltranstransferase activity
CFI14_RS15840	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFI14_RS15845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFI14_RS15850	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CFI14_RS15855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFI14_RS15865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFI14_RS15870	COG4851	CamS sex pheromone cAM373 precursor
CFI14_RS15875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFI14_RS15880	COG0154	amidase activity
CFI14_RS15885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFI14_RS15890	COG1597	lipid kinase activity
CFI14_RS15895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFI14_RS15935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS15935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS15945	COG1737	Transcriptional regulator
CFI14_RS15960	COG1278	Cold shock
CFI14_RS15965	COG0673	inositol 2-dehydrogenase activity
CFI14_RS15970	COG0513	Belongs to the DEAD box helicase family
CFI14_RS16010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFI14_RS16035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFI14_RS16045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFI14_RS16055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFI14_RS16060	COG0562	UDP-galactopyranose mutase
CFI14_RS16095	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS16120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CFI14_RS16130	COG1088	dTDP-glucose 4,6-dehydratase activity
CFI14_RS16135	COG1091	dTDP-4-dehydrorhamnose reductase activity
CFI14_RS16140	COG0582	viral genome integration into host DNA
CFI14_RS16150	COG0489	protein tyrosine kinase activity
CFI14_RS16155	COG4464	protein tyrosine phosphatase activity
CFI14_RS16165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFI14_RS16185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFI14_RS16185	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS16215	COG1215	transferase activity, transferring glycosyl groups
CFI14_RS16225	COG0562	UDP-galactopyranose mutase
CFI14_RS16260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFI14_RS16315	COG2137	regulation of response to DNA damage stimulus
CFI14_RS16320	COG3557	Belongs to the UPF0374 family
CFI14_RS16345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFI14_RS16355	COG0628	permease
CFI14_RS16365	COG1070	Carbohydrate kinase
CFI14_RS16370	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFI14_RS16380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFI14_RS16405	COG0583	DNA-binding transcription factor activity
CFI14_RS16420	COG4166	transmembrane transport
CFI14_RS16425	COG0601	transmembrane transport
CFI14_RS16430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFI14_RS16435	COG0444	Belongs to the ABC transporter superfamily
CFI14_RS16440	COG4608	Belongs to the ABC transporter superfamily
CFI14_RS16455	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS16465	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS16470	COG0438	transferase activity, transferring glycosyl groups
CFI14_RS16520	COG1063	alcohol dehydrogenase
CFI14_RS16540	COG2826	transposase and inactivated derivatives, IS30 family
CFI14_RS16590	COG1846	Transcriptional regulator
CFI14_RS16600	COG3158	transport of potassium into the cell
CFI14_RS16610	COG2826	transposase and inactivated derivatives, IS30 family
CFI14_RS16640	COG2801	Transposase and inactivated derivatives
CFI14_RS16680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFI14_RS16690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFI14_RS16705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFI14_RS16715	COG1192	Involved in chromosome partitioning
CFI14_RS16725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFI14_RS16765	COG1192	Involved in chromosome partitioning
CFI14_RS16795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFI14_RS16845	COG0783	Belongs to the Dps family
CFI14_RS16850	COG1131	(ABC) transporter
CFI14_RS16860	COG1309	transcriptional regulator
CFI14_RS16900	COG0489	protein tyrosine kinase activity
CFI14_RS16905	COG4464	protein tyrosine phosphatase activity
CFI14_RS16910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFI14_RS16985	COG1136	(ABC) transporter
CFI14_RS16990	COG0577	efflux transmembrane transporter activity
CFI14_RS17070	COG1136	(ABC) transporter
CFI14_RS17075	COG0577	efflux transmembrane transporter activity
CFI14_RS17135	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFI14_RS17140	COG1376	ErfK ybiS ycfS ynhG family protein