locus-tag	class	description
E5260_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5260_RS00015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5260_RS00020	COG0594	ribonuclease P activity
E5260_RS00025	COG0706	membrane insertase activity
E5260_RS00030	COG4166	transmembrane transport
E5260_RS00040	COG1847	R3H domain protein
E5260_RS00045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5260_RS00050	COG0445	tRNA wobble uridine modification
E5260_RS00090	COG1307	EDD domain protein, DegV family
E5260_RS00105	COG3479	Phenolic acid decarboxylase
E5260_RS00110	COG1695	Transcriptional regulator
E5260_RS00120	COG1012	belongs to the aldehyde dehydrogenase family
E5260_RS00120	COG1454	alcohol dehydrogenase
E5260_RS00125	COG1609	Transcriptional regulator
E5260_RS00135	COG1869	D-ribose catabolic process
E5260_RS00140	COG4975	Glucose uptake
E5260_RS00160	COG3730	PTS system glucitol sorbitol-specific
E5260_RS00165	COG3732	PTS system glucitol sorbitol-specific
E5260_RS00180	COG2188	Transcriptional regulator
E5260_RS00185	COG1132	(ABC) transporter
E5260_RS00190	COG1132	(ABC) transporter
E5260_RS00195	COG2207	Transcriptional regulator
E5260_RS00195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5260_RS00210	COG0395	ABC-type sugar transport system, permease component
E5260_RS00220	COG0366	Alpha amylase catalytic
E5260_RS00230	COG2972	Histidine kinase
E5260_RS00235	COG2207	Transcriptional regulator
E5260_RS00235	COG4753	response regulator
E5260_RS00245	COG3842	ATPase activity
E5260_RS00255	COG2188	Transcriptional regulator
E5260_RS00265	COG0383	alpha-mannosidase activity
E5260_RS00270	COG1940	carbohydrate kinase activity
E5260_RS00275	COG2723	6-phospho-beta-galactosidase activity
E5260_RS00305	COG1609	Transcriptional regulator
E5260_RS00305	COG2207	Transcriptional regulator
E5260_RS00380	COG1349	DNA-binding transcription factor activity
E5260_RS00385	COG2207	Transcriptional regulator
E5260_RS00390	COG2814	Major facilitator Superfamily
E5260_RS00395	COG1070	Carbohydrate kinase
E5260_RS00400	COG3254	rhamnose metabolic process
E5260_RS00405	COG4806	L-rhamnose isomerase
E5260_RS00410	COG0235	Class ii aldolase
E5260_RS00425	COG0028	Belongs to the TPP enzyme family
E5260_RS00430	COG1959	2 iron, 2 sulfur cluster binding
E5260_RS00435	COG0028	Belongs to the TPP enzyme family
E5260_RS00440	COG1304	FMN binding
E5260_RS00455	COG4512	PFAM Accessory gene regulator B
E5260_RS00475	COG1393	Belongs to the ArsC family
E5260_RS00485	COG2261	transglycosylase associated protein
E5260_RS00505	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E5260_RS00510	COG1609	Transcriptional regulator
E5260_RS00530	COG2160	L-arabinose isomerase activity
E5260_RS00535	COG0110	maltose O-acetyltransferase activity
E5260_RS00545	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5260_RS00550	COG1349	DNA-binding transcription factor activity
E5260_RS00560	COG3414	Phosphotransferase system galactitol-specific IIB component
E5260_RS00565	COG3775	system Galactitol-specific IIC component
E5260_RS00580	COG3711	transcriptional antiterminator
E5260_RS00600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5260_RS00615	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E5260_RS00630	COG2211	Major facilitator Superfamily
E5260_RS00650	COG2190	(PTS) system
E5260_RS00650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS00650	COG1263	PTS System
E5260_RS00655	COG2723	6-phospho-beta-galactosidase activity
E5260_RS00660	COG2723	6-phospho-beta-galactosidase activity
E5260_RS00670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5260_RS00675	COG1263	PTS System
E5260_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS00680	COG1737	Transcriptional regulator
E5260_RS00685	COG2190	(PTS) system
E5260_RS00685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS00685	COG1263	PTS System
E5260_RS00690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS00690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS00690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS00700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5260_RS00710	COG3711	transcriptional antiterminator
E5260_RS00720	COG2723	6-phospho-beta-galactosidase activity
E5260_RS00730	COG2971	BadF BadG BcrA BcrD
E5260_RS00735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5260_RS00745	COG2188	Transcriptional regulator
E5260_RS00750	COG2267	carboxylic ester hydrolase activity
E5260_RS00760	COG2271	Major facilitator Superfamily
E5260_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS00790	COG2271	Major facilitator Superfamily
E5260_RS00795	COG0583	DNA-binding transcription factor activity
E5260_RS00800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5260_RS00805	COG0710	3-dehydroquinate dehydratase activity
E5260_RS00825	COG0667	Aldo Keto reductase
E5260_RS00830	COG1609	Transcriptional regulator
E5260_RS00835	COG2017	converts alpha-aldose to the beta-anomer
E5260_RS00840	COG2190	(PTS) system
E5260_RS00840	COG2211	Major facilitator Superfamily
E5260_RS00860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5260_RS00865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5260_RS00870	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5260_RS00875	COG1609	Transcriptional regulator
E5260_RS00880	COG2944	sequence-specific DNA binding
E5260_RS00885	COG2184	nucleotidyltransferase activity
E5260_RS00905	COG0477	Major facilitator Superfamily
E5260_RS00915	COG1609	Transcriptional regulator
E5260_RS00920	COG1874	Beta-galactosidase
E5260_RS00930	COG1114	Component of the transport system for branched-chain amino acids
E5260_RS00940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS00990	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS01005	COG3590	peptidase
E5260_RS01010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5260_RS01030	COG1937	Protein conserved in bacteria
E5260_RS01035	COG3118	belongs to the thioredoxin family
E5260_RS01040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS01045	COG2217	Heavy metal translocating P-type atpase
E5260_RS01060	COG2226	methyltransferase
E5260_RS01070	COG1309	transcriptional regulator
E5260_RS01110	COG0076	glutamate decarboxylase activity
E5260_RS01135	COG2207	Transcriptional regulator
E5260_RS01170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5260_RS01175	COG1968	undecaprenyl-diphosphatase activity
E5260_RS01195	COG0656	L-ascorbic acid biosynthetic process
E5260_RS01205	COG0737	Belongs to the 5'-nucleotidase family
E5260_RS01260	COG0477	Major facilitator Superfamily
E5260_RS01285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E5260_RS01300	COG0697	spore germination
E5260_RS01325	COG0071	Belongs to the small heat shock protein (HSP20) family
E5260_RS01340	COG1194	a g-specific adenine glycosylase
E5260_RS01350	COG3189	MarR family transcriptional regulator
E5260_RS01355	COG1393	Belongs to the ArsC family
E5260_RS01370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5260_RS01380	COG1113	amino acid transport
E5260_RS01400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5260_RS01405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5260_RS01415	COG2315	Protein conserved in bacteria
E5260_RS01425	COG2217	Heavy metal translocating P-type atpase
E5260_RS01455	COG4989	oxidoreductase activity
E5260_RS01460	COG2151	metal-sulfur cluster biosynthetic enzyme
E5260_RS01465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5260_RS01470	COG1882	Formate acetyltransferase
E5260_RS01475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5260_RS01505	COG2814	Major facilitator Superfamily
E5260_RS01515	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5260_RS01530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5260_RS01535	COG0302	gtp cyclohydrolase
E5260_RS01545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5260_RS01580	COG0640	Transcriptional regulator
E5260_RS01585	COG1272	protein, Hemolysin III
E5260_RS01600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5260_RS01605	COG0628	permease
E5260_RS01610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5260_RS01615	COG3158	transport of potassium into the cell
E5260_RS01620	COG0531	amino acid
E5260_RS01635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5260_RS01640	COG2365	Tyrosine phosphatase family
E5260_RS01645	COG0516	GMP reductase activity
E5260_RS01650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5260_RS01655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5260_RS01670	COG1929	Belongs to the glycerate kinase type-1 family
E5260_RS01680	COG1562	ergosterol biosynthetic process
E5260_RS01685	COG1233	COG1233 Phytoene dehydrogenase and related
E5260_RS01690	COG2738	Putative neutral zinc metallopeptidase
E5260_RS01700	COG1307	EDD domain protein, DegV family
E5260_RS01710	COG1380	Effector of murein hydrolase LrgA
E5260_RS01735	COG0735	belongs to the Fur family
E5260_RS01765	COG1263	PTS System
E5260_RS01765	COG2190	(PTS) system
E5260_RS01765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS01780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS01780	COG3711	transcriptional antiterminator
E5260_RS01785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS01785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS01785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS01790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS01795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS01795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS01800	COG0383	alpha-mannosidase activity
E5260_RS01810	COG0561	phosphatase activity
E5260_RS01825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5260_RS01830	COG4619	ABC transporter
E5260_RS01835	COG0390	transport system, permease component
E5260_RS01845	COG1609	Transcriptional regulator
E5260_RS01850	COG0366	Alpha amylase catalytic
E5260_RS01855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS01855	COG1263	PTS System
E5260_RS01855	COG2190	(PTS) system
E5260_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5260_RS01885	COG1126	abc transporter atp-binding protein
E5260_RS01890	COG0765	amino acid transport
E5260_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5260_RS01900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5260_RS01905	COG0583	DNA-binding transcription factor activity
E5260_RS01920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5260_RS01925	COG0357	Ribosomal RNA small subunit methyltransferase G
E5260_RS01935	COG1192	Involved in chromosome partitioning
E5260_RS01940	COG1475	DNA binding
E5260_RS01945	COG4481	Protein conserved in bacteria
E5260_RS01950	COG0012	GTP binding
E5260_RS01960	COG0516	GMP reductase activity
E5260_RS01960	COG0517	IMP dehydrogenase activity
E5260_RS01965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5260_RS01985	COG1686	Belongs to the peptidase S11 family
E5260_RS01990	COG1247	-acetyltransferase
E5260_RS02030	COG2815	serine threonine protein kinase
E5260_RS02030	COG0515	serine threonine protein kinase
E5260_RS02040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5260_RS02050	COG1846	Transcriptional regulator
E5260_RS02050	COG1940	carbohydrate kinase activity
E5260_RS02055	COG0628	permease
E5260_RS02060	COG0588	phosphoglycerate mutase activity
E5260_RS02090	COG0477	Major facilitator Superfamily
E5260_RS02110	COG1376	ErfK ybiS ycfS ynhG family protein
E5260_RS02130	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5260_RS02145	COG0693	protein deglycase activity
E5260_RS02160	COG3711	transcriptional antiterminator
E5260_RS02185	COG2190	(PTS) system
E5260_RS02185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS02185	COG1263	PTS System
E5260_RS02190	COG2723	6-phospho-beta-galactosidase activity
E5260_RS02210	COG0783	Belongs to the Dps family
E5260_RS02220	COG1053	succinate dehydrogenase
E5260_RS02230	COG2816	NAD+ diphosphatase activity
E5260_RS02240	COG0481	GTPase activity
E5260_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS02280	COG0110	maltose O-acetyltransferase activity
E5260_RS02285	COG4221	oxidoreductase activity
E5260_RS02295	COG1309	transcriptional regulator
E5260_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5260_RS02305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5260_RS02310	COG1120	ATPase activity
E5260_RS02315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5260_RS02325	COG0477	Major facilitator Superfamily
E5260_RS02330	COG4989	oxidoreductase activity
E5260_RS02350	COG0300	oxidoreductase activity
E5260_RS02355	COG1733	regulation of RNA biosynthetic process
E5260_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
E5260_RS02380	COG1309	transcriptional regulator
E5260_RS02390	COG3279	Response regulator of the LytR AlgR family
E5260_RS02395	COG0367	asparagine synthase
E5260_RS02405	COG2814	Major facilitator Superfamily
E5260_RS02410	COG1733	regulation of RNA biosynthetic process
E5260_RS02415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5260_RS02455	COG1063	alcohol dehydrogenase
E5260_RS02510	COG2217	Heavy metal translocating P-type atpase
E5260_RS02530	COG0531	amino acid
E5260_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS02555	COG1473	amidohydrolase
E5260_RS02565	COG1132	(ABC) transporter
E5260_RS02570	COG1132	(ABC) transporter
E5260_RS02615	COG4221	oxidoreductase activity
E5260_RS02630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5260_RS02655	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5260_RS02675	COG0741	lytic transglycosylase activity
E5260_RS02680	COG0789	Transcriptional regulator
E5260_RS02690	COG2723	6-phospho-beta-galactosidase activity
E5260_RS02695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS02700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS02735	COG0577	efflux transmembrane transporter activity
E5260_RS02735	COG1136	(ABC) transporter
E5260_RS02745	COG0640	Transcriptional regulator
E5260_RS02765	COG1914	H( )-stimulated, divalent metal cation uptake system
E5260_RS02775	COG2246	polysaccharide biosynthetic process
E5260_RS02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5260_RS02780	COG5549	protein import
E5260_RS02795	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5260_RS02810	COG0410	ABC transporter
E5260_RS02815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5260_RS02815	COG0617	tRNA 3'-terminal CCA addition
E5260_RS02815	COG3620	sequence-specific DNA binding
E5260_RS02845	COG4120	Belongs to the binding-protein-dependent transport system permease family
E5260_RS02855	COG1263	PTS System
E5260_RS02855	COG2190	(PTS) system
E5260_RS02855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS02860	COG0778	Nitroreductase
E5260_RS02870	COG1132	(ABC) transporter
E5260_RS02875	COG1940	carbohydrate kinase activity
E5260_RS02900	COG0697	spore germination
E5260_RS02945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5260_RS02955	COG0583	DNA-binding transcription factor activity
E5260_RS02970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5260_RS02980	COG0242	peptide deformylase activity
E5260_RS02990	COG1328	CTP reductase activity
E5260_RS03000	COG2200	EAL domain
E5260_RS03055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5260_RS03065	COG0561	phosphatase activity
E5260_RS03070	COG0488	(ABC) transporter
E5260_RS03095	COG0640	Transcriptional regulator
E5260_RS03105	COG1511	domain protein
E5260_RS03105	COG1511	domain protein
E5260_RS03115	COG2814	Major facilitator Superfamily
E5260_RS03120	COG1132	(ABC) transporter
E5260_RS03125	COG1132	(ABC) transporter
E5260_RS03130	COG0667	Aldo Keto reductase
E5260_RS03140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5260_RS03150	COG1011	Hydrolase
E5260_RS03155	COG0110	maltose O-acetyltransferase activity
E5260_RS03160	COG0589	response to stress
E5260_RS03180	COG0656	L-ascorbic acid biosynthetic process
E5260_RS03185	COG4221	oxidoreductase activity
E5260_RS03205	COG0583	DNA-binding transcription factor activity
E5260_RS03210	COG0656	L-ascorbic acid biosynthetic process
E5260_RS03220	COG4975	Glucose uptake
E5260_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS03250	COG1063	alcohol dehydrogenase
E5260_RS03260	COG0583	DNA-binding transcription factor activity
E5260_RS03285	COG0456	acetyltransferase
E5260_RS03305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5260_RS03330	COG0789	Transcriptional regulator
E5260_RS03345	COG4221	oxidoreductase activity
E5260_RS03355	COG4152	abc transporter atp-binding protein
E5260_RS03360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5260_RS03375	COG0438	transferase activity, transferring glycosyl groups
E5260_RS03385	COG0583	DNA-binding transcription factor activity
E5260_RS03390	COG2855	membrane
E5260_RS03395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5260_RS03405	COG2814	Major facilitator Superfamily
E5260_RS03415	COG2814	Major facilitator Superfamily
E5260_RS03455	COG1136	(ABC) transporter
E5260_RS03460	COG0577	efflux transmembrane transporter activity
E5260_RS03475	COG4978	Transcriptional regulator
E5260_RS03475	COG0789	Transcriptional regulator
E5260_RS03480	COG1811	Na channel or pump
E5260_RS03495	COG4990	cell redox homeostasis
E5260_RS03510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5260_RS03515	COG4720	Psort location CytoplasmicMembrane, score
E5260_RS03560	COG0531	amino acid
E5260_RS03565	COG0710	3-dehydroquinate dehydratase activity
E5260_RS03585	COG0716	FMN binding
E5260_RS03610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5260_RS03615	COG0561	phosphatase activity
E5260_RS03630	COG1216	Glycosyl transferase, family 2
E5260_RS03635	COG2188	Transcriptional regulator
E5260_RS03640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS03645	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5260_RS03650	COG2723	6-phospho-beta-galactosidase activity
E5260_RS03655	COG2723	6-phospho-beta-galactosidase activity
E5260_RS03660	COG3048	D-serine ammonia-lyase activity
E5260_RS03665	COG1131	(ABC) transporter
E5260_RS03675	COG1309	transcriptional regulator
E5260_RS03680	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5260_RS03685	COG1827	regulation of RNA biosynthetic process
E5260_RS03715	COG1051	belongs to the nudix hydrolase family
E5260_RS03720	COG0110	maltose O-acetyltransferase activity
E5260_RS03730	COG0561	phosphatase activity
E5260_RS03740	COG0366	Alpha amylase catalytic
E5260_RS03760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5260_RS03775	COG2246	polysaccharide biosynthetic process
E5260_RS03785	COG0589	response to stress
E5260_RS03795	COG1131	(ABC) transporter
E5260_RS03800	COG1725	Transcriptional regulator
E5260_RS03815	COG1136	(ABC) transporter
E5260_RS03835	COG2365	Tyrosine phosphatase family
E5260_RS03840	COG0095	Lipoate-protein ligase
E5260_RS03845	COG3976	FMN-binding domain protein
E5260_RS03845	COG1053	succinate dehydrogenase
E5260_RS03845	COG0431	NADPH-dependent FMN reductase
E5260_RS03850	COG0431	NADPH-dependent FMN reductase
E5260_RS03850	COG1053	succinate dehydrogenase
E5260_RS03850	COG3976	FMN-binding domain protein
E5260_RS03860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5260_RS03865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5260_RS03870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5260_RS03875	COG0047	phosphoribosylformylglycinamidine synthase activity
E5260_RS03880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5260_RS03890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5260_RS03895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5260_RS03900	COG0138	bifunctional purine biosynthesis protein purh
E5260_RS03905	COG0151	Belongs to the GarS family
E5260_RS03915	COG1215	transferase activity, transferring glycosyl groups
E5260_RS03935	COG2252	PERMEase
E5260_RS03940	COG2233	PERMEase
E5260_RS03945	COG2508	Transcriptional regulator
E5260_RS03950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5260_RS03955	COG0540	Belongs to the ATCase OTCase family
E5260_RS03960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5260_RS03965	COG0505	Belongs to the CarA family
E5260_RS03970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5260_RS03975	COG0167	dihydroorotate dehydrogenase activity
E5260_RS03980	COG0284	orotidine-5'-phosphate decarboxylase activity
E5260_RS03985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5260_RS03995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E5260_RS04000	COG1074	ATP-dependent DNA helicase activity
E5260_RS04010	COG0702	epimerase
E5260_RS04015	COG0583	DNA-binding transcription factor activity
E5260_RS04025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5260_RS04030	COG0436	Aminotransferase
E5260_RS04035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5260_RS04040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5260_RS04050	COG0604	alcohol dehydrogenase
E5260_RS04055	COG0789	Transcriptional regulator
E5260_RS04060	COG2814	Major facilitator Superfamily
E5260_RS04065	COG0025	NhaP-type Na H and K H
E5260_RS04070	COG1780	Probably involved in ribonucleotide reductase function
E5260_RS04075	COG1253	flavin adenine dinucleotide binding
E5260_RS04105	COG1418	mRNA catabolic process
E5260_RS04115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5260_RS04120	COG2188	Transcriptional regulator
E5260_RS04130	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5260_RS04145	COG1396	sequence-specific DNA binding
E5260_RS04150	COG4640	response to antibiotic
E5260_RS04165	COG0564	pseudouridine synthase activity
E5260_RS04170	COG0589	response to stress
E5260_RS04175	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5260_RS04180	COG0095	Lipoate-protein ligase
E5260_RS04210	COG0626	cystathionine gamma-synthase activity
E5260_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5260_RS04220	COG1073	alpha beta
E5260_RS04230	COG0028	Belongs to the TPP enzyme family
E5260_RS04270	COG1725	Transcriptional regulator
E5260_RS04275	COG1131	(ABC) transporter
E5260_RS04285	COG1335	isochorismatase
E5260_RS04290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5260_RS04295	COG0025	NhaP-type Na H and K H
E5260_RS04300	COG0673	inositol 2-dehydrogenase activity
E5260_RS04305	COG0673	inositol 2-dehydrogenase activity
E5260_RS04315	COG1609	Transcriptional regulator
E5260_RS04325	COG0328	RNA-DNA hybrid ribonuclease activity
E5260_RS04335	COG0778	Nitroreductase
E5260_RS04340	COG2326	polyphosphate kinase activity
E5260_RS04355	COG0492	ferredoxin-NADP+ reductase activity
E5260_RS04360	COG0584	glycerophosphoryl diester phosphodiesterase
E5260_RS04365	COG1368	sulfuric ester hydrolase activity
E5260_RS04385	COG3548	integral membrane protein
E5260_RS04400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5260_RS04410	COG0300	oxidoreductase activity
E5260_RS04415	COG0789	Transcriptional regulator
E5260_RS04435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5260_RS04440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5260_RS04445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5260_RS04450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5260_RS04455	COG0131	Imidazoleglycerol-phosphate dehydratase
E5260_RS04460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5260_RS04465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5260_RS04470	COG0107	imidazoleglycerol-phosphate synthase activity
E5260_RS04475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5260_RS04480	COG0140	phosphoribosyl-ATP diphosphatase activity
E5260_RS04485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5260_RS04490	COG0110	maltose O-acetyltransferase activity
E5260_RS04495	COG0861	Integral membrane protein TerC family
E5260_RS04500	COG2084	Dehydrogenase
E5260_RS04505	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS04515	COG4120	Belongs to the binding-protein-dependent transport system permease family
E5260_RS04525	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5260_RS04530	COG2873	o-acetylhomoserine
E5260_RS04540	COG1307	EDD domain protein, DegV family
E5260_RS04545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5260_RS04550	COG2190	(PTS) system
E5260_RS04550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS04550	COG1263	PTS System
E5260_RS04570	COG0488	(ABC) transporter
E5260_RS04575	COG3706	GGDEF domain
E5260_RS04590	COG1522	sequence-specific DNA binding
E5260_RS04595	COG0791	NLP P60 protein
E5260_RS04615	COG0477	Major facilitator Superfamily
E5260_RS04640	COG3830	Belongs to the UPF0237 family
E5260_RS04645	COG2848	UPF0210 protein
E5260_RS04650	COG0745	RESPONSE REGULATOR receiver
E5260_RS04655	COG5002	protein histidine kinase activity
E5260_RS04655	COG3850	Histidine kinase
E5260_RS04660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5260_RS04665	COG4975	Glucose uptake
E5260_RS04670	COG0166	Belongs to the GPI family
E5260_RS04680	COG1136	(ABC) transporter
E5260_RS04680	COG0577	efflux transmembrane transporter activity
E5260_RS04690	COG1132	(ABC) transporter
E5260_RS04705	COG4886	Leucine-rich repeat (LRR) protein
E5260_RS04705	COG4932	domain protein
E5260_RS04825	COG1396	sequence-specific DNA binding
E5260_RS04940	COG5484	DNA packaging
E5260_RS04955	COG2868	ribosomal protein
E5260_RS05075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS05100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5260_RS05110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5260_RS05120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS05125	COG0562	UDP-galactopyranose mutase
E5260_RS05130	COG1216	Glycosyl transferase, family 2
E5260_RS05135	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05140	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05160	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05195	COG1088	dTDP-glucose 4,6-dehydratase activity
E5260_RS05200	COG0582	viral genome integration into host DNA
E5260_RS05210	COG0489	protein tyrosine kinase activity
E5260_RS05215	COG4464	protein tyrosine phosphatase activity
E5260_RS05230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5260_RS05240	COG1088	dTDP-glucose 4,6-dehydratase activity
E5260_RS05245	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5260_RS05265	COG3475	LICD family
E5260_RS05290	COG1216	Glycosyl transferase, family 2
E5260_RS05365	COG0562	UDP-galactopyranose mutase
E5260_RS05420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5260_RS05455	COG2137	regulation of response to DNA damage stimulus
E5260_RS05460	COG3557	Belongs to the UPF0374 family
E5260_RS05490	COG0628	permease
E5260_RS05495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5260_RS05500	COG2610	gluconate transmembrane transporter activity
E5260_RS05505	COG1070	Carbohydrate kinase
E5260_RS05510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5260_RS05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5260_RS05520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5260_RS05550	COG4166	transmembrane transport
E5260_RS05555	COG0601	transmembrane transport
E5260_RS05560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5260_RS05565	COG0444	Belongs to the ABC transporter superfamily
E5260_RS05570	COG4608	Belongs to the ABC transporter superfamily
E5260_RS05580	COG0582	viral genome integration into host DNA
E5260_RS05585	COG0542	response to heat
E5260_RS05605	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05610	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05620	COG1686	Belongs to the peptidase S11 family
E5260_RS05625	COG0436	Aminotransferase
E5260_RS05630	COG4703	Protein of unknown function (DUF1797)
E5260_RS05635	COG1368	sulfuric ester hydrolase activity
E5260_RS05720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5260_RS05740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5260_RS05755	COG0833	amino acid
E5260_RS05760	COG2040	homocysteine
E5260_RS05765	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5260_RS05780	COG0477	Major facilitator Superfamily
E5260_RS05795	COG0438	transferase activity, transferring glycosyl groups
E5260_RS05810	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E5260_RS05820	COG0495	leucyl-tRNA aminoacylation
E5260_RS05825	COG2244	polysaccharide biosynthetic process
E5260_RS05830	COG1187	pseudouridine synthase activity
E5260_RS05835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5260_RS05840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5260_RS05850	COG3842	ATPase activity
E5260_RS05855	COG1175	transmembrane transport
E5260_RS05860	COG0395	ABC-type sugar transport system, permease component
E5260_RS05870	COG0584	glycerophosphoryl diester phosphodiesterase
E5260_RS05875	COG1428	Deoxynucleoside kinase
E5260_RS05880	COG1970	mechanosensitive ion channel activity
E5260_RS05885	COG1511	domain protein
E5260_RS05885	COG1511	domain protein
E5260_RS05910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5260_RS05915	COG0789	Transcriptional regulator
E5260_RS05925	COG0697	spore germination
E5260_RS05930	COG0561	phosphatase activity
E5260_RS05945	COG3279	Response regulator of the LytR AlgR family
E5260_RS05965	COG1846	Transcriptional regulator
E5260_RS05980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5260_RS06015	COG0646	methionine synthase
E5260_RS06015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5260_RS06020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5260_RS06030	COG2046	Belongs to the sulfate adenylyltransferase family
E5260_RS06035	COG0529	Catalyzes the synthesis of activated sulfate
E5260_RS06040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5260_RS06050	COG0471	metal ion transport
E5260_RS06050	COG3273	potassium ion transport
E5260_RS06055	COG0534	Mate efflux family protein
E5260_RS06075	COG2153	protein acetylation
E5260_RS06080	COG0018	arginyl-trna synthetase
E5260_RS06090	COG1136	(ABC) transporter
E5260_RS06090	COG0577	efflux transmembrane transporter activity
E5260_RS06110	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5260_RS06115	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS06120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS06125	COG2723	6-phospho-beta-galactosidase activity
E5260_RS06135	COG1376	ErfK ybiS ycfS ynhG family protein
E5260_RS06140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5260_RS06145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5260_RS06155	COG0436	Aminotransferase
E5260_RS06160	COG1438	arginine binding
E5260_RS06165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5260_RS06170	COG3679	Belongs to the UPF0342 family
E5260_RS06175	COG0420	3'-5' exonuclease activity
E5260_RS06180	COG4717	serine-type aminopeptidase activity
E5260_RS06185	COG3481	metal-dependent phosphohydrolase, HD sub domain
E5260_RS06200	COG0583	DNA-binding transcription factor activity
E5260_RS06210	COG3976	FMN-binding domain protein
E5260_RS06210	COG0431	NADPH-dependent FMN reductase
E5260_RS06210	COG1053	succinate dehydrogenase
E5260_RS06260	COG2217	Heavy metal translocating P-type atpase
E5260_RS06265	COG0148	phosphopyruvate hydratase activity
E5260_RS06275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5260_RS06280	COG0463	Glycosyl transferase, family 2
E5260_RS06300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5260_RS06300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5260_RS06305	COG0307	riboflavin synthase, alpha
E5260_RS06310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5260_RS06310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5260_RS06315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5260_RS06330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5260_RS06340	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS06370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5260_RS06380	COG0537	adenosine 5'-monophosphoramidase activity
E5260_RS06385	COG1131	(ABC) transporter
E5260_RS06390	COG4473	ABC transporter
E5260_RS06395	COG0510	thiamine kinase activity
E5260_RS06400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5260_RS06410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5260_RS06415	COG1674	ftsk spoiiie
E5260_RS06420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5260_RS06445	COG0719	Fe-S assembly protein
E5260_RS06450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5260_RS06460	COG0719	Fe-S assembly protein
E5260_RS06465	COG2151	metal-sulfur cluster biosynthetic enzyme
E5260_RS06480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5260_RS06480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5260_RS06485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5260_RS06490	COG0237	dephospho-CoA kinase activity
E5260_RS06495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5260_RS06500	COG3611	Membrane attachment protein
E5260_RS06505	COG1484	DNA-dependent DNA replication
E5260_RS06510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5260_RS06515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5260_RS06520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5260_RS06525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5260_RS06535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5260_RS06540	COG0604	alcohol dehydrogenase
E5260_RS06545	COG1733	regulation of RNA biosynthetic process
E5260_RS06555	COG1215	transferase activity, transferring glycosyl groups
E5260_RS06570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5260_RS06575	COG1534	Rna-binding protein
E5260_RS06580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5260_RS06585	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5260_RS06590	COG0799	negative regulation of ribosome biogenesis
E5260_RS06595	COG2226	methyltransferase
E5260_RS06600	COG1323	Belongs to the UPF0348 family
E5260_RS06610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5260_RS06625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5260_RS06630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5260_RS06635	COG0745	RESPONSE REGULATOR receiver
E5260_RS06640	COG5002	protein histidine kinase activity
E5260_RS06650	COG0419	ATPase involved in DNA repair
E5260_RS06665	COG0706	membrane insertase activity
E5260_RS06670	COG1254	Belongs to the acylphosphatase family
E5260_RS06675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5260_RS06685	COG1733	regulation of RNA biosynthetic process
E5260_RS06690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5260_RS06695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5260_RS06695	COG0072	phenylalanine-tRNA ligase activity
E5260_RS06700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5260_RS06705	COG0572	uridine kinase
E5260_RS06710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5260_RS06725	COG4841	protein insertion into membrane
E5260_RS06735	COG0768	penicillin binding
E5260_RS06740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5260_RS06745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5260_RS06750	COG0457	Tetratricopeptide repeat
E5260_RS06750	COG0705	Rhomboid family
E5260_RS06760	COG1940	carbohydrate kinase activity
E5260_RS06780	COG0584	glycerophosphoryl diester phosphodiesterase
E5260_RS06785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5260_RS06790	COG0789	Transcriptional regulator
E5260_RS06845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5260_RS06855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5260_RS06860	COG0006	proline dipeptidase activity
E5260_RS06865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5260_RS06870	COG1302	Protein conserved in bacteria
E5260_RS06875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5260_RS06880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5260_RS06885	COG1570	exodeoxyribonuclease VII activity
E5260_RS06890	COG1722	exodeoxyribonuclease VII activity
E5260_RS06895	COG0142	geranyltranstransferase activity
E5260_RS06900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5260_RS06905	COG1438	arginine binding
E5260_RS06910	COG0497	DNA recombination
E5260_RS06925	COG1732	Glycine betaine
E5260_RS06940	COG0194	GDP metabolic process
E5260_RS06945	COG1758	RNA polymerase activity
E5260_RS06950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5260_RS06955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5260_RS06960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5260_RS06965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5260_RS06965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5260_RS06970	COG0631	protein serine/threonine phosphatase activity
E5260_RS06975	COG2815	serine threonine protein kinase
E5260_RS06975	COG0515	serine threonine protein kinase
E5260_RS06980	COG1162	GTPase activity
E5260_RS06985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5260_RS06990	COG1564	THIamine pyrophosphokinase
E5260_RS07000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5260_RS07005	COG1302	Protein conserved in bacteria
E5260_RS07010	COG1461	Dihydroxyacetone kinase
E5260_RS07015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5260_RS07020	COG0416	fatty acid biosynthetic process
E5260_RS07025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5260_RS07030	COG0571	ribonuclease III activity
E5260_RS07035	COG1196	nuclear chromosome segregation
E5260_RS07040	COG0552	protein localization to endoplasmic reticulum
E5260_RS07045	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E5260_RS07050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5260_RS07055	COG0228	four-way junction DNA binding
E5260_RS07060	COG1837	Belongs to the UPF0109 family
E5260_RS07065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5260_RS07070	COG0336	Belongs to the RNA methyltransferase TrmD family
E5260_RS07075	COG0335	large ribosomal subunit rRNA binding
E5260_RS07110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5260_RS07110	COG0512	Glutamine amidotransferase of anthranilate synthase
E5260_RS07115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5260_RS07120	COG0134	indole-3-glycerol-phosphate synthase activity
E5260_RS07125	COG0135	phosphoribosylanthranilate isomerase activity
E5260_RS07130	COG0133	tryptophan synthase activity
E5260_RS07135	COG0159	tryptophan synthase activity
E5260_RS07150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5260_RS07160	COG1473	amidohydrolase
E5260_RS07165	COG1063	alcohol dehydrogenase
E5260_RS07175	COG0300	oxidoreductase activity
E5260_RS07185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5260_RS07190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5260_RS07195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5260_RS07200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5260_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS07210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5260_RS07225	COG0439	Biotin carboxylase
E5260_RS07240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5260_RS07250	COG1811	Na channel or pump
E5260_RS07255	COG0583	DNA-binding transcription factor activity
E5260_RS07260	COG1607	acyl-coa hydrolase
E5260_RS07265	COG1162	GTPase activity
E5260_RS07275	COG0477	Major facilitator Superfamily
E5260_RS07325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5260_RS07330	COG3397	chitin binding
E5260_RS07345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E5260_RS07355	COG3152	Membrane
E5260_RS07360	COG1597	lipid kinase activity
E5260_RS07370	COG2261	transglycosylase associated protein
E5260_RS07375	COG3237	CsbD-like
E5260_RS07390	COG1942	4-Oxalocrotonate Tautomerase
E5260_RS07425	COG0531	amino acid
E5260_RS07430	COG0561	phosphatase activity
E5260_RS07435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5260_RS07435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5260_RS07455	COG2017	converts alpha-aldose to the beta-anomer
E5260_RS07460	COG1304	FMN binding
E5260_RS07480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5260_RS07480	COG1199	ATP-dependent helicase activity
E5260_RS07495	COG0017	Asparaginyl-tRNA synthetase
E5260_RS07505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5260_RS07510	COG2011	ABC-type metal ion transport system permease component
E5260_RS07515	COG1464	Belongs to the NlpA lipoprotein family
E5260_RS07525	COG1177	transmembrane transport
E5260_RS07530	COG1840	ABC-type Fe3 transport system, periplasmic component
E5260_RS07545	COG3331	DNA recombination
E5260_RS07550	COG4474	Belongs to the UPF0398 family
E5260_RS07555	COG3599	regulation of cell shape
E5260_RS07565	COG0116	Belongs to the methyltransferase superfamily
E5260_RS07575	COG0477	Major facilitator Superfamily
E5260_RS07580	COG1073	alpha beta
E5260_RS07590	COG1216	Glycosyl transferase, family 2
E5260_RS07610	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5260_RS07640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5260_RS07655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5260_RS07660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5260_RS07665	COG0564	pseudouridine synthase activity
E5260_RS07670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5260_RS07675	COG0505	Belongs to the CarA family
E5260_RS07680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5260_RS07695	COG5646	InterPro IPR014922
E5260_RS07730	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E5260_RS07740	COG1307	EDD domain protein, DegV family
E5260_RS07795	COG1113	amino acid transport
E5260_RS07810	COG1620	l-lactate permease
E5260_RS07820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5260_RS07845	COG1846	Transcriptional regulator
E5260_RS07850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5260_RS07885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5260_RS07890	COG1227	inorganic diphosphatase activity
E5260_RS07895	COG0583	DNA-binding transcription factor activity
E5260_RS07905	COG0187	DNA topoisomerase II activity
E5260_RS07910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5260_RS07920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5260_RS07925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5260_RS07930	COG4974	Belongs to the 'phage' integrase family
E5260_RS07935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E5260_RS07940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5260_RS07945	COG0758	DNA mediated transformation
E5260_RS07950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5260_RS07955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5260_RS07960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5260_RS07965	COG0583	DNA-binding transcription factor activity
E5260_RS07985	COG2814	Major facilitator Superfamily
E5260_RS07990	COG3409	Peptidoglycan-binding domain 1 protein
E5260_RS07990	COG0793	Belongs to the peptidase S41A family
E5260_RS07995	COG4479	Belongs to the UPF0346 family
E5260_RS08000	COG4698	Protein conserved in bacteria
E5260_RS08005	COG2755	lipolytic protein G-D-S-L family
E5260_RS08010	COG1307	EDD domain protein, DegV family
E5260_RS08015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5260_RS08020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5260_RS08025	COG0488	(ABC) transporter
E5260_RS08035	COG0617	tRNA 3'-terminal CCA addition
E5260_RS08040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5260_RS08045	COG0561	phosphatase activity
E5260_RS08050	COG0457	Tetratricopeptide repeat
E5260_RS08060	COG1160	GTP binding
E5260_RS08065	COG0539	negative regulation of cytoplasmic translation
E5260_RS08070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5260_RS08080	COG0514	ATP-dependent DNA helicase (RecQ)
E5260_RS08090	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5260_RS08095	COG1187	pseudouridine synthase activity
E5260_RS08100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5260_RS08105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5260_RS08115	COG4974	Belongs to the 'phage' integrase family
E5260_RS08120	COG2996	Protein conserved in bacteria
E5260_RS08135	COG0205	6-phosphofructokinase activity
E5260_RS08140	COG0587	DNA-directed DNA polymerase activity
E5260_RS08155	COG0542	response to heat
E5260_RS08165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5260_RS08170	COG2384	SAM-dependent methyltransferase
E5260_RS08195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5260_RS08195	COG0574	Belongs to the PEP-utilizing enzyme family
E5260_RS08205	COG1846	Transcriptional regulator
E5260_RS08225	COG2217	Heavy metal translocating P-type atpase
E5260_RS08230	COG0148	phosphopyruvate hydratase activity
E5260_RS08235	COG0477	Major facilitator Superfamily
E5260_RS08245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5260_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS08260	COG1349	DNA-binding transcription factor activity
E5260_RS08270	COG1393	Belongs to the ArsC family
E5260_RS08315	COG0546	phosphoglycolate phosphatase activity
E5260_RS08345	COG0583	DNA-binding transcription factor activity
E5260_RS08350	COG0604	alcohol dehydrogenase
E5260_RS08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS08365	COG2197	response regulator
E5260_RS08370	COG4585	Histidine kinase
E5260_RS08380	COG1131	(ABC) transporter
E5260_RS08390	COG0519	Catalyzes the synthesis of GMP from XMP
E5260_RS08420	COG1131	(ABC) transporter
E5260_RS08440	COG1131	(ABC) transporter
E5260_RS08445	COG1725	Transcriptional regulator
E5260_RS08450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5260_RS08455	COG0358	DNA primase activity
E5260_RS08460	COG0751	glycine-tRNA ligase activity
E5260_RS08465	COG0752	glycyl-tRNA synthetase alpha subunit
E5260_RS08470	COG1381	Involved in DNA repair and RecF pathway recombination
E5260_RS08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5260_RS08480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5260_RS08485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5260_RS08490	COG1702	phosphate starvation-inducible protein PhoH
E5260_RS08495	COG1610	YqeY-like protein
E5260_RS08500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5260_RS08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5260_RS08515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5260_RS08525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5260_RS08535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5260_RS08540	COG0124	histidyl-tRNA synthetase
E5260_RS08545	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5260_RS08545	COG3103	Sh3 type 3 domain protein
E5260_RS08545	COG4991	sh3 domain protein
E5260_RS08550	COG3001	Fructosamine kinase
E5260_RS08555	COG0546	phosphoglycolate phosphatase activity
E5260_RS08560	COG1490	D-aminoacyl-tRNA deacylase activity
E5260_RS08565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5260_RS08575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5260_RS08580	COG2264	protein methyltransferase activity
E5260_RS08585	COG2094	Belongs to the DNA glycosylase MPG family
E5260_RS08600	COG0481	GTPase activity
E5260_RS08605	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E5260_RS08610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5260_RS08615	COG1696	Membrane protein involved in D-alanine export
E5260_RS08620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5260_RS08630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5260_RS08635	COG0484	heat shock protein binding
E5260_RS08640	COG0443	Heat shock 70 kDa protein
E5260_RS08645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5260_RS08650	COG1420	regulation of RNA biosynthetic process
E5260_RS08655	COG3527	Alpha-acetolactate decarboxylase
E5260_RS08660	COG0196	riboflavin kinase activity
E5260_RS08665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5260_RS08670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5260_RS08675	COG0287	Prephenate dehydrogenase
E5260_RS08680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5260_RS08690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5260_RS08695	COG0738	Major facilitator superfamily
E5260_RS08700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5260_RS08705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5260_RS08715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5260_RS08720	COG0195	Participates in both transcription termination and antitermination
E5260_RS08725	COG0779	Required for maturation of 30S ribosomal subunits
E5260_RS08730	COG2176	DNA-directed DNA polymerase activity
E5260_RS08735	COG0442	prolyl-tRNA aminoacylation
E5260_RS08740	COG0750	zinc metalloprotease
E5260_RS08745	COG4589	Belongs to the CDS family
E5260_RS08750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5260_RS08755	COG0233	cytoplasmic translational termination
E5260_RS08760	COG0528	UMP kinase activity
E5260_RS08765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5260_RS08770	COG0052	Belongs to the universal ribosomal protein uS2 family
E5260_RS08780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5260_RS08785	COG2827	Endonuclease containing a URI domain
E5260_RS08790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5260_RS08795	COG0204	Acyl-transferase
E5260_RS08800	COG3763	UPF0154 protein
E5260_RS08805	COG4224	UPF0291 protein
E5260_RS08810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5260_RS08825	COG3425	synthase
E5260_RS08840	COG0463	Glycosyl transferase, family 2
E5260_RS08910	COG0393	Putative heavy-metal-binding
E5260_RS08925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5260_RS08930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5260_RS08930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5260_RS08935	COG5416	Lipopolysaccharide assembly protein A domain
E5260_RS08940	COG0300	oxidoreductase activity
E5260_RS08945	COG1234	tRNA 3'-trailer cleavage
E5260_RS08955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5260_RS08960	COG1349	DNA-binding transcription factor activity
E5260_RS08965	COG1105	Belongs to the carbohydrate kinase PfkB family
E5260_RS08970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS08970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS08970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5260_RS08975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5260_RS09000	COG0297	glycogen (starch) synthase activity
E5260_RS09005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5260_RS09010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5260_RS09020	COG0489	protein tyrosine kinase activity
E5260_RS09030	COG0322	excinuclease ABC activity
E5260_RS09035	COG1126	abc transporter atp-binding protein
E5260_RS09040	COG0765	amino acid transport
E5260_RS09060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5260_RS09065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5260_RS09070	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5260_RS09075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5260_RS09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5260_RS09105	COG0268	Binds directly to 16S ribosomal RNA
E5260_RS09110	COG1466	dna polymerase III delta subunit
E5260_RS09115	COG0658	competence protein
E5260_RS09115	COG2333	competence protein COMEC
E5260_RS09120	COG2131	deaminase
E5260_RS09125	COG1555	photosystem II stabilization
E5260_RS09125	COG1596	polysaccharide export
E5260_RS09130	COG3480	Lon protease (S16) C-terminal proteolytic domain
E5260_RS09135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5260_RS09140	COG0742	ribosomal rna small subunit methyltransferase
E5260_RS09145	COG4471	UPF0298 protein
E5260_RS09150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5260_RS09155	COG0772	Belongs to the SEDS family
E5260_RS09185	COG0483	inositol monophosphate 1-phosphatase activity
E5260_RS09190	COG4476	Belongs to the UPF0223 family
E5260_RS09195	COG0039	L-malate dehydrogenase activity
E5260_RS09220	COG0242	peptide deformylase activity
E5260_RS09235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5260_RS09240	COG1597	lipid kinase activity
E5260_RS09255	COG1388	LysM domain
E5260_RS09255	COG3584	3D domain protein
E5260_RS09265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5260_RS09270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5260_RS09300	COG0569	domain protein
E5260_RS09305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5260_RS09310	COG0482	sulfurtransferase activity
E5260_RS09320	COG1104	cysteine desulfurase activity
E5260_RS09325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5260_RS09335	COG0494	nUDIX hydrolase
E5260_RS09340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5260_RS09345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5260_RS09350	COG3599	regulation of cell shape
E5260_RS09360	COG0762	integral membrane protein
E5260_RS09365	COG1799	cell septum assembly
E5260_RS09380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5260_RS09385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5260_RS09390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5260_RS09395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5260_RS09410	COG0275	rRNA processing
E5260_RS09415	COG2001	Belongs to the MraZ family
E5260_RS09435	COG1674	ftsk spoiiie
E5260_RS09440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5260_RS09450	COG1114	Component of the transport system for branched-chain amino acids
E5260_RS09460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5260_RS09465	COG0628	permease
E5260_RS09475	COG2706	6-phosphogluconolactonase activity
E5260_RS09480	COG3142	Participates in the control of copper homeostasis
E5260_RS09485	COG0564	pseudouridine synthase activity
E5260_RS09490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5260_RS09495	COG2357	RelA SpoT domain protein
E5260_RS09505	COG1164	Oligoendopeptidase f
E5260_RS09515	COG4862	establishment of competence for transformation
E5260_RS09520	COG1393	Belongs to the ArsC family
E5260_RS09525	COG1234	tRNA 3'-trailer cleavage
E5260_RS09665	COG1098	S1 RNA binding domain
E5260_RS09675	COG0586	Pfam SNARE associated Golgi protein
E5260_RS09685	COG0647	UMP catabolic process
E5260_RS09690	COG4470	Protein conserved in bacteria
E5260_RS09695	COG0737	Belongs to the 5'-nucleotidase family
E5260_RS09705	COG1113	amino acid transport
E5260_RS09710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5260_RS09715	COG0827	DNA restriction-modification system
E5260_RS09745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5260_RS09755	COG0217	transcriptional regulatory protein
E5260_RS09770	COG1609	Transcriptional regulator
E5260_RS09775	COG0006	proline dipeptidase activity
E5260_RS09780	COG0789	Transcriptional regulator
E5260_RS09795	COG0668	transmembrane transport
E5260_RS09800	COG1473	amidohydrolase
E5260_RS09805	COG2171	N-acyltransferase activity
E5260_RS09810	COG0517	IMP dehydrogenase activity
E5260_RS09820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5260_RS09825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5260_RS09830	COG1719	4-vinyl reductase, 4VR
E5260_RS09835	COG3118	belongs to the thioredoxin family
E5260_RS09840	COG1193	negative regulation of DNA recombination
E5260_RS09850	COG3906	Belongs to the UPF0473 family
E5260_RS09855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5260_RS09860	COG4472	Bacterial protein of unknown function (DUF965)
E5260_RS09865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5260_RS09870	COG0513	Belongs to the DEAD box helicase family
E5260_RS09875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5260_RS09880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5260_RS09885	COG1862	Preprotein translocase
E5260_RS09890	COG0343	queuine tRNA-ribosyltransferase activity
E5260_RS09895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5260_RS09900	COG2255	four-way junction helicase activity
E5260_RS09905	COG0632	four-way junction helicase activity
E5260_RS09925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5260_RS09930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5260_RS09935	COG1692	metallophosphoesterase
E5260_RS09940	COG1418	mRNA catabolic process
E5260_RS09945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5260_RS09950	COG1546	Belongs to the CinA family
E5260_RS09950	COG1058	Belongs to the CinA family
E5260_RS09955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5260_RS09960	COG1426	Protein conserved in bacteria
E5260_RS09965	COG0612	Peptidase, M16
E5260_RS09970	COG0612	Peptidase, M16
E5260_RS09975	COG0527	aspartate kinase activity
E5260_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5260_RS09985	COG1126	abc transporter atp-binding protein
E5260_RS09990	COG0765	amino acid transport
E5260_RS09995	COG2894	cell division
E5260_RS10000	COG0850	regulation of cytokinetic process
E5260_RS10010	COG1792	Involved in formation and maintenance of cell shape
E5260_RS10015	COG1077	Cell shape determining protein MreB Mrl
E5260_RS10020	COG2003	Belongs to the UPF0758 family
E5260_RS10025	COG0285	dihydrofolate synthase activity
E5260_RS10030	COG0525	valine-tRNA ligase activity
E5260_RS10045	COG0301	tRNA thio-modification
E5260_RS10050	COG1104	cysteine desulfurase activity
E5260_RS10055	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
E5260_RS10060	COG1956	GAF domain-containing protein
E5260_RS10065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5260_RS10070	COG4493	Belongs to the UPF0637 family
E5260_RS10085	COG0640	Transcriptional regulator
E5260_RS10090	COG0366	Alpha amylase catalytic
E5260_RS10100	COG3716	PTS system mannose fructose sorbose family IID component
E5260_RS10105	COG3715	PTS system
E5260_RS10110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS10115	COG1609	Transcriptional regulator
E5260_RS10120	COG0189	ligase activity
E5260_RS10120	COG2918	glutathione biosynthetic process
E5260_RS10125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5260_RS10140	COG0589	response to stress
E5260_RS10160	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5260_RS10180	COG1464	Belongs to the NlpA lipoprotein family
E5260_RS10185	COG2011	ABC-type metal ion transport system permease component
E5260_RS10190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5260_RS10195	COG0509	glycine decarboxylation via glycine cleavage system
E5260_RS10200	COG0772	Belongs to the SEDS family
E5260_RS10210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5260_RS10215	COG1077	Cell shape determining protein MreB Mrl
E5260_RS10225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5260_RS10230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5260_RS10235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5260_RS10240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5260_RS10245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5260_RS10250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5260_RS10255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5260_RS10260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5260_RS10265	COG0356	it plays a direct role in the translocation of protons across the membrane
E5260_RS10270	COG2233	PERMEase
E5260_RS10280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5260_RS10285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5260_RS10290	COG0009	L-threonylcarbamoyladenylate synthase
E5260_RS10295	COG2890	protein-(glutamine-N5) methyltransferase activity
E5260_RS10300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5260_RS10305	COG1435	thymidine kinase activity
E5260_RS10310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5260_RS10315	COG3442	glutamine amidotransferase
E5260_RS10320	COG1482	cell wall glycoprotein biosynthetic process
E5260_RS10325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5260_RS10335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5260_RS10350	COG1132	(ABC) transporter
E5260_RS10365	COG0726	polysaccharide deacetylase
E5260_RS10640	COG1396	sequence-specific DNA binding
E5260_RS10685	COG0513	Belongs to the DEAD box helicase family
E5260_RS10690	COG0673	inositol 2-dehydrogenase activity
E5260_RS10695	COG1278	Cold shock
E5260_RS10710	COG1737	Transcriptional regulator
E5260_RS10720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS10735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5260_RS10740	COG1597	lipid kinase activity
E5260_RS10745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5260_RS10750	COG0154	amidase activity
E5260_RS10755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5260_RS10760	COG4851	CamS sex pheromone cAM373 precursor
E5260_RS10765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5260_RS10775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5260_RS10780	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
E5260_RS10785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5260_RS10790	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5260_RS10815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5260_RS10820	COG4988	ABC transporter
E5260_RS10825	COG1294	oxidase, subunit
E5260_RS10830	COG1271	oxidase subunit
E5260_RS10845	COG4684	Psort location CytoplasmicMembrane, score
E5260_RS10850	COG0531	amino acid
E5260_RS10860	COG0281	malic enzyme
E5260_RS10865	COG0583	DNA-binding transcription factor activity
E5260_RS10870	COG0583	DNA-binding transcription factor activity
E5260_RS10880	COG1053	succinate dehydrogenase
E5260_RS10885	COG0114	fumarate hydratase activity
E5260_RS10920	COG3052	prosthetic group binding
E5260_RS10940	COG0471	metal ion transport
E5260_RS10945	COG0039	L-malate dehydrogenase activity
E5260_RS10955	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5260_RS10960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5260_RS10965	COG1121	(ABC) transporter
E5260_RS10970	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E5260_RS10975	COG4977	sequence-specific DNA binding
E5260_RS10975	COG1917	Cupin 2, conserved barrel domain protein
E5260_RS10985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5260_RS10990	COG2151	metal-sulfur cluster biosynthetic enzyme
E5260_RS10995	COG0471	metal ion transport
E5260_RS11005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E5260_RS11010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5260_RS11015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5260_RS11035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5260_RS11040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5260_RS11045	COG0101	tRNA pseudouridine synthase activity
E5260_RS11055	COG1122	ATPase activity
E5260_RS11060	COG1122	ATPase activity
E5260_RS11070	COG4939	FMN-binding domain protein
E5260_RS11095	COG0203	ribosomal protein L17
E5260_RS11100	COG0202	RNA polymerase activity
E5260_RS11105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5260_RS11110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5260_RS11115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5260_RS11120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5260_RS11125	COG0563	adenylate kinase activity
E5260_RS11135	COG0200	Binds to the 23S rRNA
E5260_RS11140	COG1841	ribosomal large subunit assembly
E5260_RS11145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5260_RS11150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5260_RS11155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5260_RS11160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5260_RS11165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5260_RS11170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5260_RS11175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5260_RS11180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5260_RS11185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5260_RS11190	COG0255	Belongs to the universal ribosomal protein uL29 family
E5260_RS11195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5260_RS11200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5260_RS11205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5260_RS11210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5260_RS11215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5260_RS11220	COG0089	rRNA binding
E5260_RS11225	COG0088	Forms part of the polypeptide exit tunnel
E5260_RS11230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5260_RS11235	COG0051	transcription antitermination factor activity, RNA binding
E5260_RS11240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5260_RS11245	COG0049	tRNA binding
E5260_RS11250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5260_RS11255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5260_RS11260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5260_RS11265	COG0085	RNA polymerase activity
E5260_RS11275	COG0542	response to heat
E5260_RS11280	COG4463	regulation of RNA biosynthetic process
E5260_RS11320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5260_RS11325	COG1428	Deoxynucleoside kinase
E5260_RS11335	COG0833	amino acid
E5260_RS11340	COG0028	Belongs to the TPP enzyme family
E5260_RS11345	COG1959	2 iron, 2 sulfur cluster binding
E5260_RS11365	COG1316	TRANSCRIPTIONal
E5260_RS11375	COG2966	Psort location CytoplasmicMembrane, score
E5260_RS11380	COG1278	Cold shock
E5260_RS11400	COG2814	Major facilitator Superfamily
E5260_RS11430	COG0367	asparagine synthase
E5260_RS11435	COG0527	aspartate kinase activity
E5260_RS11440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5260_RS11490	COG0640	Transcriptional regulator
E5260_RS11495	COG0564	pseudouridine synthase activity
E5260_RS11500	COG0514	ATP-dependent DNA helicase (RecQ)
E5260_RS11515	COG4690	dipeptidase activity
E5260_RS11520	COG2502	aspartate--ammonia ligase
E5260_RS11525	COG0017	Asparaginyl-tRNA synthetase
E5260_RS11530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5260_RS11540	COG1053	succinate dehydrogenase
E5260_RS11545	COG0583	DNA-binding transcription factor activity
E5260_RS11560	COG0572	uridine kinase
E5260_RS11590	COG0308	aminopeptidase N
E5260_RS11620	COG1302	Protein conserved in bacteria
E5260_RS11635	COG2261	transglycosylase associated protein
E5260_RS11640	COG2755	lipolytic protein G-D-S-L family
E5260_RS11640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5260_RS11655	COG2814	Major facilitator Superfamily
E5260_RS11660	COG1733	regulation of RNA biosynthetic process
E5260_RS11665	COG1266	CAAX protease self-immunity
E5260_RS11670	COG1396	sequence-specific DNA binding
E5260_RS11700	COG0464	growth
E5260_RS11705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5260_RS11705	COG0519	Catalyzes the synthesis of GMP from XMP
E5260_RS11710	COG1072	(Pantothenic acid kinase))
E5260_RS11715	COG2070	2-Nitropropane dioxygenase
E5260_RS11720	COG3973	AAA domain
E5260_RS11725	COG0586	Pfam SNARE associated Golgi protein
E5260_RS11730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E5260_RS11730	COG0456	acetyltransferase
E5260_RS11735	COG0475	glutathione-regulated potassium exporter activity
E5260_RS11735	COG0569	domain protein
E5260_RS11740	COG0588	phosphoglycerate mutase activity
E5260_RS11755	COG2076	Multidrug Resistance protein
E5260_RS11765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5260_RS11795	COG1846	Transcriptional regulator
E5260_RS11800	COG0531	amino acid
E5260_RS11805	COG3394	polysaccharide catabolic process
E5260_RS11810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS11810	COG1263	PTS System
E5260_RS11820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS11820	COG2190	(PTS) system
E5260_RS11820	COG1263	PTS System
E5260_RS11825	COG0765	amino acid transport
E5260_RS11830	COG0765	amino acid transport
E5260_RS11835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5260_RS11850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5260_RS11855	COG0436	Aminotransferase
E5260_RS11860	COG0546	phosphoglycolate phosphatase activity
E5260_RS11875	COG0735	belongs to the Fur family
E5260_RS11880	COG0194	GDP metabolic process
E5260_RS11905	COG0531	amino acid
E5260_RS11920	COG2936	dipeptidyl-peptidase activity
E5260_RS11925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5260_RS11925	COG2755	lipolytic protein G-D-S-L family
E5260_RS11935	COG2267	carboxylic ester hydrolase activity
E5260_RS11940	COG0028	Belongs to the TPP enzyme family
E5260_RS11945	COG0196	riboflavin kinase activity
E5260_RS11950	COG0028	Belongs to the TPP enzyme family
E5260_RS11955	COG2252	PERMEase
E5260_RS11970	COG3475	LICD family
E5260_RS11980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5260_RS11985	COG0248	Ppx GppA phosphatase
E5260_RS11990	COG0477	Major facilitator Superfamily
E5260_RS12005	COG1393	Belongs to the ArsC family
E5260_RS12020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5260_RS12035	COG0778	Nitroreductase
E5260_RS12050	COG2017	converts alpha-aldose to the beta-anomer
E5260_RS12060	COG0561	phosphatase activity
E5260_RS12070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5260_RS12075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5260_RS12100	COG0025	NhaP-type Na H and K H
E5260_RS12105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5260_RS12115	COG0708	Exodeoxyribonuclease III
E5260_RS12130	COG0802	atpase or kinase
E5260_RS12135	COG0280	phosphate acetyltransferase
E5260_RS12140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5260_RS12145	COG0561	phosphatase activity
E5260_RS12155	COG1126	abc transporter atp-binding protein
E5260_RS12160	COG0765	amino acid transport
E5260_RS12170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5260_RS12175	COG0557	exoribonuclease II activity
E5260_RS12185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5260_RS12190	COG0038	chloride channel
E5260_RS12200	COG0148	phosphopyruvate hydratase activity
E5260_RS12205	COG0149	triose-phosphate isomerase activity
E5260_RS12210	COG0126	phosphoglycerate kinase activity
E5260_RS12220	COG2390	Transcriptional regulator
E5260_RS12225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5260_RS12235	COG0740	serine-type endopeptidase activity
E5260_RS12240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5260_RS12250	COG1481	regulation of sporulation
E5260_RS12260	COG1660	Displays ATPase and GTPase activities
E5260_RS12270	COG0165	Argininosuccinate lyase
E5260_RS12275	COG0137	argininosuccinate synthase activity
E5260_RS12280	COG1854	S-ribosylhomocysteine lyase activity
E5260_RS12285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5260_RS12290	COG0556	nucleotide-excision repair
E5260_RS12300	COG2814	Major facilitator Superfamily
E5260_RS12310	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS12320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5260_RS12330	COG2323	membrane
E5260_RS12335	COG0492	ferredoxin-NADP+ reductase activity
E5260_RS12350	COG1215	transferase activity, transferring glycosyl groups
E5260_RS12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5260_RS12380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5260_RS12385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5260_RS12390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5260_RS12395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5260_RS12400	COG1950	PFAM Membrane protein of
E5260_RS12405	COG1983	PspC domain protein
E5260_RS12410	COG0704	Plays a role in the regulation of phosphate uptake
E5260_RS12415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5260_RS12420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5260_RS12425	COG0581	inorganic phosphate transmembrane transporter activity
E5260_RS12430	COG0573	inorganic phosphate transmembrane transporter activity
E5260_RS12435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5260_RS12440	COG5002	protein histidine kinase activity
E5260_RS12445	COG0745	RESPONSE REGULATOR receiver
E5260_RS12460	COG0653	protein targeting
E5260_RS12475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E5260_RS12480	COG1739	Uncharacterized protein family UPF0029
E5260_RS12485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5260_RS12490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5260_RS12495	COG0531	amino acid
E5260_RS12500	COG0459	protein refolding
E5260_RS12505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5260_RS12515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5260_RS12520	COG0488	(ABC) transporter
E5260_RS12525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5260_RS12530	COG0456	acetyltransferase
E5260_RS12535	COG0456	acetyltransferase
E5260_RS12540	COG1214	PFAM Peptidase M22, glycoprotease
E5260_RS12550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E5260_RS12560	COG3639	organic phosphonate transmembrane transporter activity
E5260_RS12565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5260_RS12570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5260_RS12575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5260_RS12590	COG4467	Involved in initiation control of chromosome replication
E5260_RS12595	COG0470	DNA polymerase III
E5260_RS12600	COG3870	Protein conserved in bacteria
E5260_RS12605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5260_RS12645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5260_RS12650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5260_RS12655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5260_RS12670	COG2813	Specifically methylates the guanine in position
E5260_RS12675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5260_RS12680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5260_RS12690	COG1611	Belongs to the LOG family
E5260_RS12710	COG0222	ribosome binding
E5260_RS12715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5260_RS12720	COG0081	regulation of translation
E5260_RS12725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5260_RS12735	COG0250	Participates in transcription elongation, termination and antitermination
E5260_RS12745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5260_RS12760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5260_RS12765	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E5260_RS12770	COG0215	cysteine-tRNA ligase activity
E5260_RS12775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5260_RS12780	COG4956	integral membrane protein (PIN domain superfamily)
E5260_RS12790	COG0756	dUTP diphosphatase activity
E5260_RS12800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5260_RS12815	COG0588	phosphoglycerate mutase activity
E5260_RS12820	COG0697	spore germination
E5260_RS12830	COG1316	TRANSCRIPTIONal
E5260_RS12835	COG0825	malonyl-CoA metabolic process
E5260_RS12845	COG0439	Biotin carboxylase
E5260_RS12855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5260_RS12860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS12860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS12865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS12865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS12870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E5260_RS12870	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E5260_RS12880	COG3716	PTS system mannose fructose sorbose family IID component
E5260_RS12885	COG3715	PTS system
E5260_RS12905	COG0083	homoserine kinase activity
E5260_RS12910	COG0460	homoserine dehydrogenase
E5260_RS12915	COG3091	SprT-like family
E5260_RS12920	COG2183	response to ionizing radiation
E5260_RS12935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5260_RS12940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5260_RS12950	COG2188	Transcriptional regulator
E5260_RS12960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5260_RS13010	COG3104	oligopeptide transport
E5260_RS13050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5260_RS13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5260_RS13060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5260_RS13075	COG0037	tRNA processing
E5260_RS13080	COG1098	S1 RNA binding domain
E5260_RS13090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5260_RS13095	COG2244	polysaccharide biosynthetic process
E5260_RS13100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5260_RS13105	COG0193	aminoacyl-tRNA hydrolase activity
E5260_RS13110	COG0039	L-malate dehydrogenase activity
E5260_RS13130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5260_RS13135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5260_RS13140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5260_RS13145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5260_RS13150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5260_RS13155	COG0505	Belongs to the CarA family
E5260_RS13160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5260_RS13180	COG3158	transport of potassium into the cell
E5260_RS13185	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5260_RS13190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5260_RS13195	COG0736	holo-[acyl-carrier-protein] synthase activity
E5260_RS13205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5260_RS13215	COG0501	Belongs to the peptidase M48B family
E5260_RS13220	COG1704	LemA family
E5260_RS13225	COG3764	Sortase (surface protein transpeptidase)
E5260_RS13235	COG0254	rRNA binding
E5260_RS13240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5260_RS13245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5260_RS13260	COG1760	l-serine dehydratase
E5260_RS13265	COG1760	l-serine dehydratase
E5260_RS13270	COG0814	amino acid
E5260_RS13275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5260_RS13280	COG0504	CTP synthase activity
E5260_RS13285	COG3343	RNA polymerase activity
E5260_RS13295	COG0095	Lipoate-protein ligase
E5260_RS13300	COG1078	dGTPase activity
E5260_RS13320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5260_RS13330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5260_RS13335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5260_RS13365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5260_RS13365	COG1321	iron dependent repressor
E5260_RS13370	COG1121	(ABC) transporter
E5260_RS13375	COG1073	alpha beta
E5260_RS13380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5260_RS13385	COG4466	Protein conserved in bacteria
E5260_RS13390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5260_RS13395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E5260_RS13400	COG0084	hydrolase, TatD family'
E5260_RS13405	COG2814	Major facilitator Superfamily
E5260_RS13410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5260_RS13410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5260_RS13420	COG1801	Protein of unknown function DUF72
E5260_RS13425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5260_RS13440	COG0248	Ppx GppA phosphatase
E5260_RS13455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5260_RS13465	COG1940	carbohydrate kinase activity
E5260_RS13470	COG2723	6-phospho-beta-galactosidase activity
E5260_RS13475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS13490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS13495	COG2188	Transcriptional regulator
E5260_RS13500	COG0180	Tryptophanyl-tRNA synthetase
E5260_RS13505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5260_RS13510	COG3973	AAA domain
E5260_RS13545	COG2274	protein secretion by the type I secretion system
E5260_RS13570	COG3279	Response regulator of the LytR AlgR family
E5260_RS13590	COG0463	Glycosyl transferase, family 2
E5260_RS13630	COG1114	Component of the transport system for branched-chain amino acids
E5260_RS13635	COG0561	phosphatase activity
E5260_RS13645	COG0561	phosphatase activity
E5260_RS13655	COG0110	maltose O-acetyltransferase activity
E5260_RS13715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS13725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5260_RS13735	COG1125	glycine betaine transport
E5260_RS13750	COG0300	oxidoreductase activity
E5260_RS13780	COG1881	PFAM PEBP family protein
E5260_RS13785	COG3759	membrane
E5260_RS13795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5260_RS13815	COG0004	ammonium transporteR
E5260_RS13820	COG2814	Major facilitator Superfamily
E5260_RS13835	COG1134	teichoic acid transport
E5260_RS13840	COG1682	transport, permease protein
E5260_RS13850	COG0436	Aminotransferase
E5260_RS13855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5260_RS13860	COG2011	ABC-type metal ion transport system permease component
E5260_RS13890	COG1268	BioY protein
E5260_RS13925	COG1012	belongs to the aldehyde dehydrogenase family
E5260_RS13925	COG1454	alcohol dehydrogenase
E5260_RS13935	COG1131	(ABC) transporter
E5260_RS13940	COG1725	Transcriptional regulator
E5260_RS13970	COG3842	ATPase activity
E5260_RS14010	COG1252	NADH dehydrogenase
E5260_RS14015	COG1846	Transcriptional regulator
E5260_RS14025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5260_RS14055	COG1388	LysM domain
E5260_RS14055	COG3942	CHAP domain
E5260_RS14060	COG0741	lytic transglycosylase activity
E5260_RS14075	COG1136	(ABC) transporter
E5260_RS14080	COG0577	efflux transmembrane transporter activity
E5260_RS14090	COG2818	Glycosylase
E5260_RS14095	COG1033	growth of symbiont in host cell
E5260_RS14095	COG2409	Drug exporters of the RND superfamily
E5260_RS14105	COG2357	RelA SpoT domain protein
E5260_RS14115	COG0277	FAD linked oxidase domain protein
E5260_RS14120	COG1316	TRANSCRIPTIONal
E5260_RS14135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5260_RS14140	COG1737	Transcriptional regulator
E5260_RS14150	COG0745	RESPONSE REGULATOR receiver
E5260_RS14155	COG5002	protein histidine kinase activity
E5260_RS14165	COG2814	Major facilitator Superfamily
E5260_RS14185	COG1914	H( )-stimulated, divalent metal cation uptake system
E5260_RS14190	COG1309	transcriptional regulator
E5260_RS14195	COG1959	2 iron, 2 sulfur cluster binding
E5260_RS14205	COG0163	prenyltransferase activity
E5260_RS14215	COG2190	(PTS) system
E5260_RS14215	COG1263	PTS System
E5260_RS14215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS14220	COG1263	PTS System
E5260_RS14220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5260_RS14220	COG2190	(PTS) system
E5260_RS14225	COG0366	Alpha amylase catalytic
E5260_RS14230	COG2188	Transcriptional regulator
E5260_RS14255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5260_RS14260	COG0626	cystathionine gamma-synthase activity
E5260_RS14265	COG1045	serine acetyltransferase
E5260_RS14270	COG0431	NADPH-dependent FMN reductase
E5260_RS14300	COG3118	belongs to the thioredoxin family
E5260_RS14310	COG0246	Mannitol dehydrogenase
E5260_RS14315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5260_RS14325	COG2213	PTS system mannitol-specific
E5260_RS14340	COG3976	FMN-binding domain protein
E5260_RS14340	COG1053	succinate dehydrogenase
E5260_RS14350	COG0363	glucosamine-6-phosphate deaminase activity
E5260_RS14365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5260_RS14375	COG0386	Belongs to the glutathione peroxidase family
E5260_RS14385	COG4172	Belongs to the ABC transporter superfamily
E5260_RS14405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5260_RS14410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5260_RS14440	COG0667	Aldo Keto reductase
E5260_RS14445	COG0406	alpha-ribazole phosphatase activity
E5260_RS14450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5260_RS14455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5260_RS14465	COG4166	transmembrane transport
E5260_RS14470	COG4166	transmembrane transport
E5260_RS14545	COG3842	ATPase activity
E5260_RS14550	COG0366	Alpha amylase catalytic
E5260_RS14560	COG3833	ABC-type maltose transport systems, permease component
E5260_RS14565	COG1175	transmembrane transport
E5260_RS14570	COG2182	Extracellular solute-binding protein
E5260_RS14575	COG0366	Alpha amylase catalytic
E5260_RS14580	COG1609	Transcriptional regulator
E5260_RS14585	COG1609	Transcriptional regulator
E5260_RS14590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS14595	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E5260_RS14600	COG1461	Dihydroxyacetone kinase
E5260_RS14605	COG2376	Dihydroxyacetone kinase
E5260_RS14610	COG2376	Dihydroxyacetone kinase
E5260_RS14615	COG1309	transcriptional regulator
E5260_RS14620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5260_RS14625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5260_RS14640	COG1131	(ABC) transporter
E5260_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS14670	COG2188	Transcriptional regulator
E5260_RS14680	COG4720	Psort location CytoplasmicMembrane, score
E5260_RS14685	COG1122	ATPase activity
E5260_RS14690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5260_RS14720	COG0667	Aldo Keto reductase
E5260_RS14725	COG0656	L-ascorbic acid biosynthetic process
E5260_RS14730	COG2807	transmembrane transport
E5260_RS14770	COG1983	PspC domain protein
E5260_RS14775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5260_RS14780	COG2267	carboxylic ester hydrolase activity
E5260_RS14790	COG1113	amino acid transport
E5260_RS14805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5260_RS14815	COG0352	thiamine-phosphate diphosphorylase activity
E5260_RS14820	COG0351	phosphomethylpyrimidine kinase
E5260_RS14825	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5260_RS14830	COG0604	alcohol dehydrogenase
E5260_RS14835	COG1606	tRNA processing
E5260_RS14840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5260_RS14845	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E5260_RS14850	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E5260_RS14855	COG1691	(AIR) carboxylase
E5260_RS14860	COG3875	lactate racemase activity
E5260_RS14865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5260_RS14870	COG0310	cobalt ion transport
E5260_RS14875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5260_RS14880	COG1122	ATPase activity
E5260_RS14905	COG4166	transmembrane transport
E5260_RS14915	COG3022	response to hydroperoxide
E5260_RS14920	COG2267	carboxylic ester hydrolase activity
E5260_RS14940	COG0604	alcohol dehydrogenase
E5260_RS14975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5260_RS14995	COG2368	4-hydroxyphenylacetate
E5260_RS15000	COG2365	Tyrosine phosphatase family
E5260_RS15010	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E5260_RS15015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5260_RS15020	COG2508	Transcriptional regulator
E5260_RS15025	COG0778	Nitroreductase
E5260_RS15035	COG1028	Short-chain dehydrogenase reductase Sdr
E5260_RS15040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5260_RS15055	COG0471	metal ion transport
E5260_RS15060	COG0431	NADPH-dependent FMN reductase
E5260_RS15060	COG3976	FMN-binding domain protein
E5260_RS15060	COG1053	succinate dehydrogenase
E5260_RS15080	COG1573	uracil-dna glycosylase
E5260_RS15085	COG1012	belongs to the aldehyde dehydrogenase family
E5260_RS15095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5260_RS15100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5260_RS15105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5260_RS15110	COG4853	Protein conserved in bacteria
E5260_RS15120	COG5002	protein histidine kinase activity
E5260_RS15125	COG0745	RESPONSE REGULATOR receiver
E5260_RS15140	COG1278	Cold shock
E5260_RS15150	COG1554	hydrolase, family 65, central catalytic
E5260_RS15155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5260_RS15165	COG3103	Sh3 type 3 domain protein
E5260_RS15165	COG0366	Alpha amylase catalytic
E5260_RS15170	COG0058	SHG alpha-glucan phosphorylase activity
E5260_RS15175	COG0297	glycogen (starch) synthase activity
E5260_RS15180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5260_RS15185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5260_RS15190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5260_RS15195	COG4166	transmembrane transport
E5260_RS15200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5260_RS15205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5260_RS15210	COG2814	Major facilitator Superfamily
E5260_RS15215	COG0305	Participates in initiation and elongation during chromosome replication
E5260_RS15220	COG0359	binds to the 23S rRNA
E5260_RS15230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5260_RS15235	COG0629	single-stranded DNA binding
E5260_RS15240	COG0360	Binds together with S18 to 16S ribosomal RNA
E5260_RS15250	COG0187	DNA topoisomerase II activity
E5260_RS15255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5260_RS15260	COG2501	S4 domain
E5260_RS15280	COG1278	Cold shock