locus-tag	class	description
DHT46_RS00035	COG0270	DNA (cytosine-5-)-methyltransferase activity
DHT46_RS00125	COG3953	SLT domain
DHT46_RS00125	COG5280	Phage tail tape measure protein TP901
DHT46_RS00175	COG0772	Belongs to the SEDS family
DHT46_RS00185	COG1116	anion transmembrane transporter activity
DHT46_RS00190	COG1316	TRANSCRIPTIONal
DHT46_RS00200	COG0463	Glycosyl transferase, family 2
DHT46_RS00215	COG3425	synthase
DHT46_RS00230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DHT46_RS00235	COG4224	UPF0291 protein
DHT46_RS00240	COG3763	UPF0154 protein
DHT46_RS00245	COG0204	Acyl-transferase
DHT46_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DHT46_RS00255	COG2827	Endonuclease containing a URI domain
DHT46_RS00260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DHT46_RS00270	COG0052	Belongs to the universal ribosomal protein uS2 family
DHT46_RS00275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DHT46_RS00280	COG0528	UMP kinase activity
DHT46_RS00285	COG0233	cytoplasmic translational termination
DHT46_RS00290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DHT46_RS00295	COG4589	Belongs to the CDS family
DHT46_RS00300	COG0750	zinc metalloprotease
DHT46_RS00305	COG0442	prolyl-tRNA aminoacylation
DHT46_RS00310	COG2176	DNA-directed DNA polymerase activity
DHT46_RS00315	COG0779	Required for maturation of 30S ribosomal subunits
DHT46_RS00320	COG0195	Participates in both transcription termination and antitermination
DHT46_RS00325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DHT46_RS00335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DHT46_RS00340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DHT46_RS00345	COG0738	Major facilitator superfamily
DHT46_RS00350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DHT46_RS00360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DHT46_RS00365	COG0287	Prephenate dehydrogenase
DHT46_RS00370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DHT46_RS00375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DHT46_RS00380	COG0196	riboflavin kinase activity
DHT46_RS00385	COG3527	Alpha-acetolactate decarboxylase
DHT46_RS00390	COG1420	regulation of RNA biosynthetic process
DHT46_RS00395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DHT46_RS00400	COG0443	Heat shock 70 kDa protein
DHT46_RS00405	COG0484	heat shock protein binding
DHT46_RS00410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DHT46_RS00420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DHT46_RS00425	COG1696	Membrane protein involved in D-alanine export
DHT46_RS00430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DHT46_RS00435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DHT46_RS00440	COG0481	GTPase activity
DHT46_RS00455	COG2094	Belongs to the DNA glycosylase MPG family
DHT46_RS00460	COG2264	protein methyltransferase activity
DHT46_RS00465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DHT46_RS00475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DHT46_RS00480	COG1490	D-aminoacyl-tRNA deacylase activity
DHT46_RS00485	COG0546	phosphoglycolate phosphatase activity
DHT46_RS00490	COG3001	Fructosamine kinase
DHT46_RS00495	COG0860	N-Acetylmuramoyl-L-alanine amidase
DHT46_RS00495	COG4991	sh3 domain protein
DHT46_RS00495	COG3103	Sh3 type 3 domain protein
DHT46_RS00500	COG0124	histidyl-tRNA synthetase
DHT46_RS00505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DHT46_RS00515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DHT46_RS00525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DHT46_RS00535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DHT46_RS00540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DHT46_RS00545	COG1610	YqeY-like protein
DHT46_RS00550	COG1702	phosphate starvation-inducible protein PhoH
DHT46_RS00555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DHT46_RS00560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DHT46_RS00565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DHT46_RS00570	COG1381	Involved in DNA repair and RecF pathway recombination
DHT46_RS00575	COG0752	glycyl-tRNA synthetase alpha subunit
DHT46_RS00580	COG0751	glycine-tRNA ligase activity
DHT46_RS00585	COG0358	DNA primase activity
DHT46_RS00590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DHT46_RS00600	COG1725	Transcriptional regulator
DHT46_RS00605	COG1131	(ABC) transporter
DHT46_RS00625	COG1131	(ABC) transporter
DHT46_RS00655	COG0519	Catalyzes the synthesis of GMP from XMP
DHT46_RS00665	COG1131	(ABC) transporter
DHT46_RS00675	COG4585	Histidine kinase
DHT46_RS00680	COG2197	response regulator
DHT46_RS00685	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS00695	COG0604	alcohol dehydrogenase
DHT46_RS00700	COG0583	DNA-binding transcription factor activity
DHT46_RS00730	COG0546	phosphoglycolate phosphatase activity
DHT46_RS00775	COG1393	Belongs to the ArsC family
DHT46_RS00785	COG1349	DNA-binding transcription factor activity
DHT46_RS00795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DHT46_RS00805	COG0477	Major facilitator Superfamily
DHT46_RS00810	COG0148	phosphopyruvate hydratase activity
DHT46_RS00835	COG1846	Transcriptional regulator
DHT46_RS00845	COG0574	Belongs to the PEP-utilizing enzyme family
DHT46_RS00845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DHT46_RS00870	COG2384	SAM-dependent methyltransferase
DHT46_RS00875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DHT46_RS00885	COG0542	response to heat
DHT46_RS00895	COG0587	DNA-directed DNA polymerase activity
DHT46_RS00900	COG0205	6-phosphofructokinase activity
DHT46_RS00920	COG2996	Protein conserved in bacteria
DHT46_RS00925	COG4974	Belongs to the 'phage' integrase family
DHT46_RS00935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DHT46_RS00940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DHT46_RS00945	COG1187	pseudouridine synthase activity
DHT46_RS00950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DHT46_RS00960	COG0514	ATP-dependent DNA helicase (RecQ)
DHT46_RS00970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DHT46_RS00975	COG0539	negative regulation of cytoplasmic translation
DHT46_RS00980	COG1160	GTP binding
DHT46_RS00995	COG0457	Tetratricopeptide repeat
DHT46_RS01000	COG0561	phosphatase activity
DHT46_RS01005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DHT46_RS01010	COG0617	tRNA 3'-terminal CCA addition
DHT46_RS01020	COG0488	(ABC) transporter
DHT46_RS01025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DHT46_RS01030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DHT46_RS01035	COG1307	EDD domain protein, DegV family
DHT46_RS01040	COG2755	lipolytic protein G-D-S-L family
DHT46_RS01045	COG4698	Protein conserved in bacteria
DHT46_RS01050	COG4479	Belongs to the UPF0346 family
DHT46_RS01055	COG0793	Belongs to the peptidase S41A family
DHT46_RS01055	COG3409	Peptidoglycan-binding domain 1 protein
DHT46_RS01060	COG2814	Major facilitator Superfamily
DHT46_RS01075	COG0583	DNA-binding transcription factor activity
DHT46_RS01080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DHT46_RS01090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DHT46_RS01095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DHT46_RS01100	COG0758	DNA mediated transformation
DHT46_RS01105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DHT46_RS01110	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DHT46_RS01115	COG4974	Belongs to the 'phage' integrase family
DHT46_RS01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DHT46_RS01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DHT46_RS01135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DHT46_RS01140	COG0187	DNA topoisomerase II activity
DHT46_RS01150	COG0583	DNA-binding transcription factor activity
DHT46_RS01155	COG1227	inorganic diphosphatase activity
DHT46_RS01160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DHT46_RS01200	COG1846	Transcriptional regulator
DHT46_RS01215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DHT46_RS01225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DHT46_RS01235	COG1620	l-lactate permease
DHT46_RS01250	COG1113	amino acid transport
DHT46_RS01310	COG1307	EDD domain protein, DegV family
DHT46_RS01320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DHT46_RS01325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DHT46_RS01330	COG1131	(ABC) transporter
DHT46_RS01355	COG5646	InterPro IPR014922
DHT46_RS01365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DHT46_RS01370	COG0505	Belongs to the CarA family
DHT46_RS01375	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DHT46_RS01380	COG0564	pseudouridine synthase activity
DHT46_RS01385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DHT46_RS01390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DHT46_RS01405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DHT46_RS01435	COG1619	proteins homologs of microcin C7 resistance protein MccF
DHT46_RS01455	COG1216	Glycosyl transferase, family 2
DHT46_RS01465	COG1073	alpha beta
DHT46_RS01470	COG0477	Major facilitator Superfamily
DHT46_RS01480	COG0116	Belongs to the methyltransferase superfamily
DHT46_RS01490	COG3599	regulation of cell shape
DHT46_RS01495	COG4474	Belongs to the UPF0398 family
DHT46_RS01500	COG3331	DNA recombination
DHT46_RS01515	COG1840	ABC-type Fe3 transport system, periplasmic component
DHT46_RS01520	COG1177	transmembrane transport
DHT46_RS01530	COG1464	Belongs to the NlpA lipoprotein family
DHT46_RS01535	COG2011	ABC-type metal ion transport system permease component
DHT46_RS01540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DHT46_RS01555	COG0017	Asparaginyl-tRNA synthetase
DHT46_RS01570	COG1199	ATP-dependent helicase activity
DHT46_RS01570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DHT46_RS01595	COG1304	FMN binding
DHT46_RS01600	COG2017	converts alpha-aldose to the beta-anomer
DHT46_RS01620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DHT46_RS01620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DHT46_RS01625	COG0561	phosphatase activity
DHT46_RS01630	COG0531	amino acid
DHT46_RS01670	COG1942	4-Oxalocrotonate Tautomerase
DHT46_RS01685	COG3237	CsbD-like
DHT46_RS01690	COG2261	transglycosylase associated protein
DHT46_RS01705	COG1597	lipid kinase activity
DHT46_RS01710	COG3152	Membrane
DHT46_RS01720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DHT46_RS01735	COG3397	chitin binding
DHT46_RS01740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DHT46_RS01775	COG0477	Major facilitator Superfamily
DHT46_RS01785	COG1162	GTPase activity
DHT46_RS01790	COG1607	acyl-coa hydrolase
DHT46_RS01795	COG0583	DNA-binding transcription factor activity
DHT46_RS01800	COG1811	Na channel or pump
DHT46_RS01810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DHT46_RS01825	COG0439	Biotin carboxylase
DHT46_RS01840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DHT46_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS01850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DHT46_RS01855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DHT46_RS01860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DHT46_RS01865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DHT46_RS01875	COG0300	oxidoreductase activity
DHT46_RS01885	COG1063	alcohol dehydrogenase
DHT46_RS01890	COG1473	amidohydrolase
DHT46_RS01900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DHT46_RS01915	COG0159	tryptophan synthase activity
DHT46_RS01920	COG0133	tryptophan synthase activity
DHT46_RS01925	COG0135	phosphoribosylanthranilate isomerase activity
DHT46_RS01930	COG0134	indole-3-glycerol-phosphate synthase activity
DHT46_RS01935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DHT46_RS01940	COG0512	Glutamine amidotransferase of anthranilate synthase
DHT46_RS01940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DHT46_RS01975	COG0335	large ribosomal subunit rRNA binding
DHT46_RS01980	COG0336	Belongs to the RNA methyltransferase TrmD family
DHT46_RS01985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DHT46_RS01990	COG1837	Belongs to the UPF0109 family
DHT46_RS01995	COG0228	four-way junction DNA binding
DHT46_RS02000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DHT46_RS02005	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DHT46_RS02010	COG0552	protein localization to endoplasmic reticulum
DHT46_RS02015	COG1196	nuclear chromosome segregation
DHT46_RS02020	COG0571	ribonuclease III activity
DHT46_RS02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DHT46_RS02030	COG0416	fatty acid biosynthetic process
DHT46_RS02035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DHT46_RS02040	COG1461	Dihydroxyacetone kinase
DHT46_RS02045	COG1302	Protein conserved in bacteria
DHT46_RS02050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DHT46_RS02060	COG1564	THIamine pyrophosphokinase
DHT46_RS02065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DHT46_RS02070	COG1162	GTPase activity
DHT46_RS02075	COG2815	serine threonine protein kinase
DHT46_RS02075	COG0515	serine threonine protein kinase
DHT46_RS02080	COG0631	protein serine/threonine phosphatase activity
DHT46_RS02085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DHT46_RS02085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DHT46_RS02090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DHT46_RS02095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DHT46_RS02100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DHT46_RS02105	COG1758	RNA polymerase activity
DHT46_RS02110	COG0194	GDP metabolic process
DHT46_RS02125	COG1732	Glycine betaine
DHT46_RS02140	COG0497	DNA recombination
DHT46_RS02145	COG1438	arginine binding
DHT46_RS02150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DHT46_RS02155	COG0142	geranyltranstransferase activity
DHT46_RS02160	COG1722	exodeoxyribonuclease VII activity
DHT46_RS02165	COG1570	exodeoxyribonuclease VII activity
DHT46_RS02170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DHT46_RS02175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DHT46_RS02180	COG1302	Protein conserved in bacteria
DHT46_RS02185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DHT46_RS02190	COG0006	proline dipeptidase activity
DHT46_RS02195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DHT46_RS02205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DHT46_RS02260	COG0789	Transcriptional regulator
DHT46_RS02265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DHT46_RS02270	COG0584	glycerophosphoryl diester phosphodiesterase
DHT46_RS02290	COG1940	carbohydrate kinase activity
DHT46_RS02300	COG0705	Rhomboid family
DHT46_RS02300	COG0457	Tetratricopeptide repeat
DHT46_RS02305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DHT46_RS02310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DHT46_RS02315	COG0768	penicillin binding
DHT46_RS02325	COG4841	protein insertion into membrane
DHT46_RS02340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DHT46_RS02345	COG0572	uridine kinase
DHT46_RS02350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DHT46_RS02355	COG0072	phenylalanine-tRNA ligase activity
DHT46_RS02355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHT46_RS02360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DHT46_RS02365	COG1733	regulation of RNA biosynthetic process
DHT46_RS02375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DHT46_RS02380	COG1254	Belongs to the acylphosphatase family
DHT46_RS02385	COG0706	membrane insertase activity
DHT46_RS02400	COG0419	ATPase involved in DNA repair
DHT46_RS02410	COG5002	protein histidine kinase activity
DHT46_RS02415	COG0745	RESPONSE REGULATOR receiver
DHT46_RS02420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DHT46_RS02425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DHT46_RS02440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DHT46_RS02450	COG1323	Belongs to the UPF0348 family
DHT46_RS02455	COG2226	methyltransferase
DHT46_RS02460	COG0799	negative regulation of ribosome biogenesis
DHT46_RS02465	COG1713	HD superfamily hydrolase involved in NAD metabolism
DHT46_RS02470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DHT46_RS02475	COG1534	Rna-binding protein
DHT46_RS02495	COG1215	transferase activity, transferring glycosyl groups
DHT46_RS02505	COG1733	regulation of RNA biosynthetic process
DHT46_RS02510	COG0604	alcohol dehydrogenase
DHT46_RS02515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DHT46_RS02525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DHT46_RS02530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DHT46_RS02535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DHT46_RS02540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DHT46_RS02545	COG1484	DNA-dependent DNA replication
DHT46_RS02550	COG3611	Membrane attachment protein
DHT46_RS02555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DHT46_RS02560	COG0237	dephospho-CoA kinase activity
DHT46_RS02565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DHT46_RS02570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DHT46_RS02570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DHT46_RS02585	COG2151	metal-sulfur cluster biosynthetic enzyme
DHT46_RS02590	COG0719	Fe-S assembly protein
DHT46_RS02600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DHT46_RS02605	COG0719	Fe-S assembly protein
DHT46_RS02630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DHT46_RS02635	COG1674	ftsk spoiiie
DHT46_RS02640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHT46_RS02650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DHT46_RS02655	COG0510	thiamine kinase activity
DHT46_RS02660	COG4473	ABC transporter
DHT46_RS02665	COG1131	(ABC) transporter
DHT46_RS02670	COG0537	adenosine 5'-monophosphoramidase activity
DHT46_RS02680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DHT46_RS02710	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS02720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DHT46_RS02735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DHT46_RS02740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DHT46_RS02740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DHT46_RS02745	COG0307	riboflavin synthase, alpha
DHT46_RS02750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DHT46_RS02750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DHT46_RS02770	COG0463	Glycosyl transferase, family 2
DHT46_RS02775	COG0586	Pfam SNARE associated Golgi protein
DHT46_RS02780	COG0463	Glycosyl transferase, family 2
DHT46_RS02790	COG0745	RESPONSE REGULATOR receiver
DHT46_RS02795	COG3850	Histidine kinase
DHT46_RS02795	COG5002	protein histidine kinase activity
DHT46_RS02815	COG3976	FMN-binding domain protein
DHT46_RS02815	COG1053	succinate dehydrogenase
DHT46_RS02815	COG0431	NADPH-dependent FMN reductase
DHT46_RS02830	COG0583	DNA-binding transcription factor activity
DHT46_RS02845	COG3481	metal-dependent phosphohydrolase, HD sub domain
DHT46_RS02850	COG4717	serine-type aminopeptidase activity
DHT46_RS02855	COG0420	3'-5' exonuclease activity
DHT46_RS02860	COG3679	Belongs to the UPF0342 family
DHT46_RS02865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DHT46_RS02875	COG1438	arginine binding
DHT46_RS02880	COG0436	Aminotransferase
DHT46_RS02890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DHT46_RS02895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DHT46_RS02900	COG1376	ErfK ybiS ycfS ynhG family protein
DHT46_RS02910	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS02915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS02920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS02925	COG1447	Phosphotransferase system cellobiose-specific component IIA
DHT46_RS02945	COG1136	(ABC) transporter
DHT46_RS02945	COG0577	efflux transmembrane transporter activity
DHT46_RS02955	COG0018	arginyl-trna synthetase
DHT46_RS02960	COG2153	protein acetylation
DHT46_RS02980	COG0534	Mate efflux family protein
DHT46_RS02985	COG0471	metal ion transport
DHT46_RS02985	COG3273	potassium ion transport
DHT46_RS02995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DHT46_RS03000	COG0529	Catalyzes the synthesis of activated sulfate
DHT46_RS03005	COG2046	Belongs to the sulfate adenylyltransferase family
DHT46_RS03015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DHT46_RS03020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DHT46_RS03020	COG0646	methionine synthase
DHT46_RS03060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DHT46_RS03075	COG1846	Transcriptional regulator
DHT46_RS03095	COG3279	Response regulator of the LytR AlgR family
DHT46_RS03115	COG0561	phosphatase activity
DHT46_RS03120	COG0697	spore germination
DHT46_RS03130	COG0789	Transcriptional regulator
DHT46_RS03135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DHT46_RS03165	COG1511	domain protein
DHT46_RS03165	COG1511	domain protein
DHT46_RS03170	COG1970	mechanosensitive ion channel activity
DHT46_RS03175	COG1428	Deoxynucleoside kinase
DHT46_RS03180	COG0584	glycerophosphoryl diester phosphodiesterase
DHT46_RS03190	COG0395	ABC-type sugar transport system, permease component
DHT46_RS03195	COG1175	transmembrane transport
DHT46_RS03200	COG3842	ATPase activity
DHT46_RS03210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DHT46_RS03215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DHT46_RS03220	COG1187	pseudouridine synthase activity
DHT46_RS03225	COG2244	polysaccharide biosynthetic process
DHT46_RS03230	COG0495	leucyl-tRNA aminoacylation
DHT46_RS03240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DHT46_RS03255	COG0438	transferase activity, transferring glycosyl groups
DHT46_RS03270	COG0477	Major facilitator Superfamily
DHT46_RS03275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DHT46_RS03290	COG0438	transferase activity, transferring glycosyl groups
DHT46_RS03295	COG2040	homocysteine
DHT46_RS03300	COG0833	amino acid
DHT46_RS03305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DHT46_RS03320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DHT46_RS03340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DHT46_RS03430	COG1368	sulfuric ester hydrolase activity
DHT46_RS03435	COG4703	Protein of unknown function (DUF1797)
DHT46_RS03440	COG0436	Aminotransferase
DHT46_RS03445	COG1686	Belongs to the peptidase S11 family
DHT46_RS03455	COG0438	transferase activity, transferring glycosyl groups
DHT46_RS03460	COG0438	transferase activity, transferring glycosyl groups
DHT46_RS03480	COG0542	response to heat
DHT46_RS03485	COG0582	viral genome integration into host DNA
DHT46_RS03495	COG4608	Belongs to the ABC transporter superfamily
DHT46_RS03500	COG0444	Belongs to the ABC transporter superfamily
DHT46_RS03505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DHT46_RS03510	COG0601	transmembrane transport
DHT46_RS03515	COG4166	transmembrane transport
DHT46_RS03550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DHT46_RS03555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DHT46_RS03560	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DHT46_RS03565	COG1070	Carbohydrate kinase
DHT46_RS03570	COG2610	gluconate transmembrane transporter activity
DHT46_RS03575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DHT46_RS03580	COG0628	permease
DHT46_RS03605	COG3557	Belongs to the UPF0374 family
DHT46_RS03610	COG2137	regulation of response to DNA damage stimulus
DHT46_RS03645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DHT46_RS03665	COG2207	Transcriptional regulator
DHT46_RS03665	COG1609	Transcriptional regulator
DHT46_RS03700	COG0562	UDP-galactopyranose mutase
DHT46_RS03740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DHT46_RS03740	COG1215	transferase activity, transferring glycosyl groups
DHT46_RS03750	COG1216	Glycosyl transferase, family 2
DHT46_RS03755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DHT46_RS03765	COG4464	protein tyrosine phosphatase activity
DHT46_RS03770	COG0489	protein tyrosine kinase activity
DHT46_RS03780	COG0582	viral genome integration into host DNA
DHT46_RS03790	COG1091	dTDP-4-dehydrorhamnose reductase activity
DHT46_RS03795	COG1088	dTDP-glucose 4,6-dehydratase activity
DHT46_RS03805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DHT46_RS03835	COG0110	maltose O-acetyltransferase activity
DHT46_RS03840	COG1215	transferase activity, transferring glycosyl groups
DHT46_RS03840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DHT46_RS03875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS03885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DHT46_RS03895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DHT46_RS03920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS03940	COG0673	inositol 2-dehydrogenase activity
DHT46_RS03945	COG1278	Cold shock
DHT46_RS03960	COG1737	Transcriptional regulator
DHT46_RS03970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS03985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DHT46_RS03990	COG1597	lipid kinase activity
DHT46_RS03995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DHT46_RS04000	COG0154	amidase activity
DHT46_RS04005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DHT46_RS04010	COG4851	CamS sex pheromone cAM373 precursor
DHT46_RS04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DHT46_RS04025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DHT46_RS04030	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DHT46_RS04035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DHT46_RS04040	COG1705	Flagellar rod assembly protein muramidase FlgJ
DHT46_RS04055	COG0142	geranyltranstransferase activity
DHT46_RS04070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DHT46_RS04075	COG4988	ABC transporter
DHT46_RS04080	COG1294	oxidase, subunit
DHT46_RS04085	COG1271	oxidase subunit
DHT46_RS04100	COG4684	Psort location CytoplasmicMembrane, score
DHT46_RS04105	COG0531	amino acid
DHT46_RS04115	COG0281	malic enzyme
DHT46_RS04120	COG0583	DNA-binding transcription factor activity
DHT46_RS04125	COG0583	DNA-binding transcription factor activity
DHT46_RS04135	COG1053	succinate dehydrogenase
DHT46_RS04140	COG0114	fumarate hydratase activity
DHT46_RS04160	COG3052	prosthetic group binding
DHT46_RS04180	COG0471	metal ion transport
DHT46_RS04185	COG0039	L-malate dehydrogenase activity
DHT46_RS04195	COG0803	Belongs to the bacterial solute-binding protein 9 family
DHT46_RS04200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DHT46_RS04205	COG1121	(ABC) transporter
DHT46_RS04210	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DHT46_RS04215	COG1917	Cupin 2, conserved barrel domain protein
DHT46_RS04215	COG4977	sequence-specific DNA binding
DHT46_RS04225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DHT46_RS04230	COG2151	metal-sulfur cluster biosynthetic enzyme
DHT46_RS04235	COG0471	metal ion transport
DHT46_RS04240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DHT46_RS04245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DHT46_RS04250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DHT46_RS04255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DHT46_RS04275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DHT46_RS04280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DHT46_RS04285	COG0101	tRNA pseudouridine synthase activity
DHT46_RS04295	COG1122	ATPase activity
DHT46_RS04300	COG1122	ATPase activity
DHT46_RS04310	COG4939	FMN-binding domain protein
DHT46_RS04335	COG0203	ribosomal protein L17
DHT46_RS04340	COG0202	RNA polymerase activity
DHT46_RS04345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DHT46_RS04350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DHT46_RS04355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DHT46_RS04360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DHT46_RS04365	COG0563	adenylate kinase activity
DHT46_RS04375	COG0200	Binds to the 23S rRNA
DHT46_RS04380	COG1841	ribosomal large subunit assembly
DHT46_RS04385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DHT46_RS04390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DHT46_RS04395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DHT46_RS04400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DHT46_RS04405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DHT46_RS04410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DHT46_RS04415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DHT46_RS04420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DHT46_RS04425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DHT46_RS04430	COG0255	Belongs to the universal ribosomal protein uL29 family
DHT46_RS04435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DHT46_RS04440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DHT46_RS04445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DHT46_RS04450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DHT46_RS04455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DHT46_RS04460	COG0089	rRNA binding
DHT46_RS04465	COG0088	Forms part of the polypeptide exit tunnel
DHT46_RS04470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DHT46_RS04475	COG0051	transcription antitermination factor activity, RNA binding
DHT46_RS04480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DHT46_RS04485	COG0049	tRNA binding
DHT46_RS04490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DHT46_RS04495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DHT46_RS04500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DHT46_RS04505	COG0085	RNA polymerase activity
DHT46_RS04515	COG0542	response to heat
DHT46_RS04520	COG4463	regulation of RNA biosynthetic process
DHT46_RS04565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DHT46_RS04570	COG1428	Deoxynucleoside kinase
DHT46_RS04580	COG0833	amino acid
DHT46_RS04585	COG0028	Belongs to the TPP enzyme family
DHT46_RS04590	COG1959	2 iron, 2 sulfur cluster binding
DHT46_RS04610	COG1316	TRANSCRIPTIONal
DHT46_RS04620	COG2966	Psort location CytoplasmicMembrane, score
DHT46_RS04625	COG1278	Cold shock
DHT46_RS04645	COG2814	Major facilitator Superfamily
DHT46_RS04695	COG0367	asparagine synthase
DHT46_RS04700	COG0527	aspartate kinase activity
DHT46_RS04705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DHT46_RS04755	COG0640	Transcriptional regulator
DHT46_RS04760	COG0564	pseudouridine synthase activity
DHT46_RS04765	COG0514	ATP-dependent DNA helicase (RecQ)
DHT46_RS04785	COG4690	dipeptidase activity
DHT46_RS04790	COG2502	aspartate--ammonia ligase
DHT46_RS04795	COG0017	Asparaginyl-tRNA synthetase
DHT46_RS04800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DHT46_RS04810	COG1053	succinate dehydrogenase
DHT46_RS04815	COG0583	DNA-binding transcription factor activity
DHT46_RS04830	COG0572	uridine kinase
DHT46_RS04860	COG0308	aminopeptidase N
DHT46_RS04890	COG1302	Protein conserved in bacteria
DHT46_RS04905	COG2261	transglycosylase associated protein
DHT46_RS04910	COG2755	lipolytic protein G-D-S-L family
DHT46_RS04910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DHT46_RS04925	COG2814	Major facilitator Superfamily
DHT46_RS04930	COG1733	regulation of RNA biosynthetic process
DHT46_RS04935	COG1266	CAAX protease self-immunity
DHT46_RS04940	COG1396	sequence-specific DNA binding
DHT46_RS04970	COG0464	growth
DHT46_RS04975	COG0519	Catalyzes the synthesis of GMP from XMP
DHT46_RS04975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DHT46_RS04980	COG1072	(Pantothenic acid kinase))
DHT46_RS04985	COG2070	2-Nitropropane dioxygenase
DHT46_RS04990	COG3973	AAA domain
DHT46_RS04995	COG0586	Pfam SNARE associated Golgi protein
DHT46_RS05000	COG0456	acetyltransferase
DHT46_RS05000	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DHT46_RS05005	COG0475	glutathione-regulated potassium exporter activity
DHT46_RS05005	COG0569	domain protein
DHT46_RS05010	COG0588	phosphoglycerate mutase activity
DHT46_RS05025	COG2076	Multidrug Resistance protein
DHT46_RS05035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DHT46_RS05065	COG1846	Transcriptional regulator
DHT46_RS05075	COG0531	amino acid
DHT46_RS05080	COG3394	polysaccharide catabolic process
DHT46_RS05085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS05085	COG1263	PTS System
DHT46_RS05095	COG1263	PTS System
DHT46_RS05095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS05095	COG2190	(PTS) system
DHT46_RS05100	COG0765	amino acid transport
DHT46_RS05105	COG0765	amino acid transport
DHT46_RS05110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DHT46_RS05130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DHT46_RS05135	COG0436	Aminotransferase
DHT46_RS05140	COG0546	phosphoglycolate phosphatase activity
DHT46_RS05155	COG0735	belongs to the Fur family
DHT46_RS05160	COG0194	GDP metabolic process
DHT46_RS05185	COG0531	amino acid
DHT46_RS05200	COG2936	dipeptidyl-peptidase activity
DHT46_RS05205	COG2755	lipolytic protein G-D-S-L family
DHT46_RS05205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DHT46_RS05215	COG2267	carboxylic ester hydrolase activity
DHT46_RS05220	COG0028	Belongs to the TPP enzyme family
DHT46_RS05225	COG0196	riboflavin kinase activity
DHT46_RS05230	COG0028	Belongs to the TPP enzyme family
DHT46_RS05235	COG2252	PERMEase
DHT46_RS05250	COG3475	LICD family
DHT46_RS05260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DHT46_RS05265	COG0248	Ppx GppA phosphatase
DHT46_RS05265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DHT46_RS05270	COG0477	Major facilitator Superfamily
DHT46_RS05285	COG1393	Belongs to the ArsC family
DHT46_RS05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DHT46_RS05320	COG0778	Nitroreductase
DHT46_RS05335	COG2017	converts alpha-aldose to the beta-anomer
DHT46_RS05345	COG0561	phosphatase activity
DHT46_RS05355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DHT46_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DHT46_RS05385	COG0025	NhaP-type Na H and K H
DHT46_RS05390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DHT46_RS05400	COG0708	Exodeoxyribonuclease III
DHT46_RS05415	COG0802	atpase or kinase
DHT46_RS05420	COG0280	phosphate acetyltransferase
DHT46_RS05425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DHT46_RS05430	COG0561	phosphatase activity
DHT46_RS05440	COG1126	abc transporter atp-binding protein
DHT46_RS05445	COG0765	amino acid transport
DHT46_RS05455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DHT46_RS05460	COG0557	exoribonuclease II activity
DHT46_RS05470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DHT46_RS05475	COG0038	chloride channel
DHT46_RS05490	COG0148	phosphopyruvate hydratase activity
DHT46_RS05495	COG0149	triose-phosphate isomerase activity
DHT46_RS05500	COG0126	phosphoglycerate kinase activity
DHT46_RS05510	COG2390	Transcriptional regulator
DHT46_RS05515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DHT46_RS05525	COG0740	serine-type endopeptidase activity
DHT46_RS05530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DHT46_RS05540	COG1481	regulation of sporulation
DHT46_RS05550	COG1660	Displays ATPase and GTPase activities
DHT46_RS05560	COG0165	Argininosuccinate lyase
DHT46_RS05565	COG0137	argininosuccinate synthase activity
DHT46_RS05570	COG1854	S-ribosylhomocysteine lyase activity
DHT46_RS05575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DHT46_RS05580	COG0556	nucleotide-excision repair
DHT46_RS05590	COG2814	Major facilitator Superfamily
DHT46_RS05600	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS05610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DHT46_RS05620	COG2323	membrane
DHT46_RS05625	COG0492	ferredoxin-NADP+ reductase activity
DHT46_RS05640	COG1215	transferase activity, transferring glycosyl groups
DHT46_RS05660	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS05670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DHT46_RS05675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DHT46_RS05680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DHT46_RS05685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DHT46_RS05690	COG1950	PFAM Membrane protein of
DHT46_RS05695	COG1983	PspC domain protein
DHT46_RS05700	COG0704	Plays a role in the regulation of phosphate uptake
DHT46_RS05705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DHT46_RS05710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DHT46_RS05715	COG0581	inorganic phosphate transmembrane transporter activity
DHT46_RS05720	COG0573	inorganic phosphate transmembrane transporter activity
DHT46_RS05725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DHT46_RS05730	COG5002	protein histidine kinase activity
DHT46_RS05735	COG0745	RESPONSE REGULATOR receiver
DHT46_RS05750	COG0653	protein targeting
DHT46_RS05765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DHT46_RS05770	COG1739	Uncharacterized protein family UPF0029
DHT46_RS05775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DHT46_RS05780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DHT46_RS05785	COG0531	amino acid
DHT46_RS05790	COG0459	protein refolding
DHT46_RS05795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DHT46_RS05805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DHT46_RS05810	COG0488	(ABC) transporter
DHT46_RS05820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DHT46_RS05825	COG0456	acetyltransferase
DHT46_RS05830	COG0456	acetyltransferase
DHT46_RS05835	COG1214	PFAM Peptidase M22, glycoprotease
DHT46_RS05845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DHT46_RS05855	COG3639	organic phosphonate transmembrane transporter activity
DHT46_RS05860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DHT46_RS05865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DHT46_RS05870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DHT46_RS05885	COG4467	Involved in initiation control of chromosome replication
DHT46_RS05890	COG0470	DNA polymerase III
DHT46_RS05895	COG3870	Protein conserved in bacteria
DHT46_RS05900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DHT46_RS05910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DHT46_RS05915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DHT46_RS05920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DHT46_RS05935	COG2813	Specifically methylates the guanine in position
DHT46_RS05940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DHT46_RS05945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DHT46_RS05955	COG1611	Belongs to the LOG family
DHT46_RS05975	COG0222	ribosome binding
DHT46_RS05980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DHT46_RS05985	COG0081	regulation of translation
DHT46_RS05990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DHT46_RS06000	COG0250	Participates in transcription elongation, termination and antitermination
DHT46_RS06010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DHT46_RS06025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DHT46_RS06030	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DHT46_RS06035	COG0215	cysteine-tRNA ligase activity
DHT46_RS06040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DHT46_RS06045	COG4956	integral membrane protein (PIN domain superfamily)
DHT46_RS06065	COG0756	dUTP diphosphatase activity
DHT46_RS06075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DHT46_RS06090	COG0588	phosphoglycerate mutase activity
DHT46_RS06095	COG0697	spore germination
DHT46_RS06105	COG1316	TRANSCRIPTIONal
DHT46_RS06110	COG0825	malonyl-CoA metabolic process
DHT46_RS06120	COG0439	Biotin carboxylase
DHT46_RS06130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DHT46_RS06135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS06135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS06140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS06140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS06145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DHT46_RS06145	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DHT46_RS06155	COG3716	PTS system mannose fructose sorbose family IID component
DHT46_RS06160	COG3715	PTS system
DHT46_RS06180	COG0083	homoserine kinase activity
DHT46_RS06185	COG0460	homoserine dehydrogenase
DHT46_RS06190	COG3091	SprT-like family
DHT46_RS06195	COG2183	response to ionizing radiation
DHT46_RS06210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DHT46_RS06215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DHT46_RS06225	COG2188	Transcriptional regulator
DHT46_RS06235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DHT46_RS06285	COG3104	oligopeptide transport
DHT46_RS06325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DHT46_RS06330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DHT46_RS06335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DHT46_RS06350	COG0037	tRNA processing
DHT46_RS06355	COG1098	S1 RNA binding domain
DHT46_RS06365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DHT46_RS06370	COG2244	polysaccharide biosynthetic process
DHT46_RS06375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DHT46_RS06380	COG0193	aminoacyl-tRNA hydrolase activity
DHT46_RS06385	COG0039	L-malate dehydrogenase activity
DHT46_RS06405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DHT46_RS06410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DHT46_RS06415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DHT46_RS06420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DHT46_RS06425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DHT46_RS06430	COG0505	Belongs to the CarA family
DHT46_RS06435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DHT46_RS06455	COG3158	transport of potassium into the cell
DHT46_RS06460	COG2337	Toxic component of a toxin-antitoxin (TA) module
DHT46_RS06465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DHT46_RS06470	COG0736	holo-[acyl-carrier-protein] synthase activity
DHT46_RS06485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DHT46_RS06495	COG0501	Belongs to the peptidase M48B family
DHT46_RS06500	COG1704	LemA family
DHT46_RS06505	COG3764	Sortase (surface protein transpeptidase)
DHT46_RS06515	COG0254	rRNA binding
DHT46_RS06520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DHT46_RS06525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DHT46_RS06540	COG1760	l-serine dehydratase
DHT46_RS06545	COG1760	l-serine dehydratase
DHT46_RS06555	COG0814	amino acid
DHT46_RS06560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DHT46_RS06565	COG0504	CTP synthase activity
DHT46_RS06570	COG3343	RNA polymerase activity
DHT46_RS06580	COG0095	Lipoate-protein ligase
DHT46_RS06585	COG1078	dGTPase activity
DHT46_RS06605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DHT46_RS06615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DHT46_RS06620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DHT46_RS06625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DHT46_RS06625	COG1321	iron dependent repressor
DHT46_RS06630	COG1121	(ABC) transporter
DHT46_RS06635	COG1073	alpha beta
DHT46_RS06645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DHT46_RS06650	COG4466	Protein conserved in bacteria
DHT46_RS06655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DHT46_RS06660	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DHT46_RS06665	COG0084	hydrolase, TatD family'
DHT46_RS06670	COG2814	Major facilitator Superfamily
DHT46_RS06675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHT46_RS06675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHT46_RS06685	COG1801	Protein of unknown function DUF72
DHT46_RS06690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DHT46_RS06705	COG0248	Ppx GppA phosphatase
DHT46_RS06710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DHT46_RS06720	COG1940	carbohydrate kinase activity
DHT46_RS06725	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS06730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS06745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS06750	COG2188	Transcriptional regulator
DHT46_RS06755	COG0180	Tryptophanyl-tRNA synthetase
DHT46_RS06760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DHT46_RS06765	COG3973	AAA domain
DHT46_RS06800	COG2274	protein secretion by the type I secretion system
DHT46_RS06825	COG3290	protein histidine kinase activity
DHT46_RS06865	COG1114	Component of the transport system for branched-chain amino acids
DHT46_RS06870	COG0561	phosphatase activity
DHT46_RS06880	COG0561	phosphatase activity
DHT46_RS06890	COG0110	maltose O-acetyltransferase activity
DHT46_RS06935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS06945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DHT46_RS06955	COG1125	glycine betaine transport
DHT46_RS06975	COG0300	oxidoreductase activity
DHT46_RS07005	COG1881	PFAM PEBP family protein
DHT46_RS07010	COG3759	membrane
DHT46_RS07020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DHT46_RS07040	COG0004	ammonium transporteR
DHT46_RS07045	COG2814	Major facilitator Superfamily
DHT46_RS07060	COG1134	teichoic acid transport
DHT46_RS07065	COG1682	transport, permease protein
DHT46_RS07075	COG0436	Aminotransferase
DHT46_RS07090	COG1268	BioY protein
DHT46_RS07125	COG1454	alcohol dehydrogenase
DHT46_RS07125	COG1012	belongs to the aldehyde dehydrogenase family
DHT46_RS07135	COG1131	(ABC) transporter
DHT46_RS07140	COG1725	Transcriptional regulator
DHT46_RS07170	COG3842	ATPase activity
DHT46_RS07195	COG1252	NADH dehydrogenase
DHT46_RS07200	COG1846	Transcriptional regulator
DHT46_RS07210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DHT46_RS07240	COG1388	LysM domain
DHT46_RS07240	COG3942	CHAP domain
DHT46_RS07245	COG0741	lytic transglycosylase activity
DHT46_RS07260	COG1136	(ABC) transporter
DHT46_RS07265	COG0577	efflux transmembrane transporter activity
DHT46_RS07275	COG2818	Glycosylase
DHT46_RS07280	COG1033	growth of symbiont in host cell
DHT46_RS07280	COG2409	Drug exporters of the RND superfamily
DHT46_RS07290	COG2357	RelA SpoT domain protein
DHT46_RS07300	COG0277	FAD linked oxidase domain protein
DHT46_RS07305	COG1316	TRANSCRIPTIONal
DHT46_RS07320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS07325	COG1737	Transcriptional regulator
DHT46_RS07335	COG0745	RESPONSE REGULATOR receiver
DHT46_RS07340	COG5002	protein histidine kinase activity
DHT46_RS07350	COG2814	Major facilitator Superfamily
DHT46_RS07370	COG1914	H( )-stimulated, divalent metal cation uptake system
DHT46_RS07375	COG1309	transcriptional regulator
DHT46_RS07380	COG1959	2 iron, 2 sulfur cluster binding
DHT46_RS07390	COG0163	prenyltransferase activity
DHT46_RS07405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DHT46_RS07410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DHT46_RS07415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DHT46_RS07425	COG2190	(PTS) system
DHT46_RS07425	COG1263	PTS System
DHT46_RS07425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS07430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS07430	COG1263	PTS System
DHT46_RS07430	COG2190	(PTS) system
DHT46_RS07435	COG0366	Alpha amylase catalytic
DHT46_RS07440	COG2188	Transcriptional regulator
DHT46_RS07470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DHT46_RS07475	COG0626	cystathionine gamma-synthase activity
DHT46_RS07480	COG1045	serine acetyltransferase
DHT46_RS07500	COG3964	amidohydrolase
DHT46_RS07515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS07520	COG2188	Transcriptional regulator
DHT46_RS07525	COG0431	NADPH-dependent FMN reductase
DHT46_RS07555	COG3118	belongs to the thioredoxin family
DHT46_RS07565	COG0246	Mannitol dehydrogenase
DHT46_RS07570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS07580	COG2213	PTS system mannitol-specific
DHT46_RS07595	COG3976	FMN-binding domain protein
DHT46_RS07595	COG1053	succinate dehydrogenase
DHT46_RS07605	COG0363	glucosamine-6-phosphate deaminase activity
DHT46_RS07620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DHT46_RS07630	COG0386	Belongs to the glutathione peroxidase family
DHT46_RS07640	COG4172	Belongs to the ABC transporter superfamily
DHT46_RS07650	COG0488	(ABC) transporter
DHT46_RS07655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DHT46_RS07660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DHT46_RS07690	COG0667	Aldo Keto reductase
DHT46_RS07695	COG0406	alpha-ribazole phosphatase activity
DHT46_RS07700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DHT46_RS07705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DHT46_RS07715	COG4166	transmembrane transport
DHT46_RS07720	COG4166	transmembrane transport
DHT46_RS07745	COG1757	Na H antiporter
DHT46_RS07800	COG3842	ATPase activity
DHT46_RS07805	COG0366	Alpha amylase catalytic
DHT46_RS07815	COG3833	ABC-type maltose transport systems, permease component
DHT46_RS07820	COG1175	transmembrane transport
DHT46_RS07825	COG2182	Extracellular solute-binding protein
DHT46_RS07830	COG0366	Alpha amylase catalytic
DHT46_RS07835	COG1609	Transcriptional regulator
DHT46_RS07840	COG1609	Transcriptional regulator
DHT46_RS07845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS07850	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DHT46_RS07855	COG1461	Dihydroxyacetone kinase
DHT46_RS07860	COG2376	Dihydroxyacetone kinase
DHT46_RS07865	COG2376	Dihydroxyacetone kinase
DHT46_RS07870	COG1309	transcriptional regulator
DHT46_RS07875	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DHT46_RS07880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DHT46_RS07895	COG1131	(ABC) transporter
DHT46_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS07925	COG2188	Transcriptional regulator
DHT46_RS07935	COG4720	Psort location CytoplasmicMembrane, score
DHT46_RS07940	COG1122	ATPase activity
DHT46_RS07945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DHT46_RS07975	COG0667	Aldo Keto reductase
DHT46_RS07980	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS07985	COG2807	transmembrane transport
DHT46_RS08025	COG1983	PspC domain protein
DHT46_RS08035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DHT46_RS08050	COG1518	maintenance of DNA repeat elements
DHT46_RS08055	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
DHT46_RS08070	COG1113	amino acid transport
DHT46_RS08085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DHT46_RS08095	COG0352	thiamine-phosphate diphosphorylase activity
DHT46_RS08100	COG0351	phosphomethylpyrimidine kinase
DHT46_RS08105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DHT46_RS08110	COG0604	alcohol dehydrogenase
DHT46_RS08115	COG1606	tRNA processing
DHT46_RS08120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS08125	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DHT46_RS08130	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DHT46_RS08135	COG1691	(AIR) carboxylase
DHT46_RS08140	COG3875	lactate racemase activity
DHT46_RS08145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DHT46_RS08150	COG0310	cobalt ion transport
DHT46_RS08155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DHT46_RS08160	COG1122	ATPase activity
DHT46_RS08185	COG4166	transmembrane transport
DHT46_RS08195	COG3022	response to hydroperoxide
DHT46_RS08200	COG2267	carboxylic ester hydrolase activity
DHT46_RS08225	COG0604	alcohol dehydrogenase
DHT46_RS08260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DHT46_RS08280	COG2368	4-hydroxyphenylacetate
DHT46_RS08285	COG2365	Tyrosine phosphatase family
DHT46_RS08295	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DHT46_RS08300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DHT46_RS08310	COG2508	Transcriptional regulator
DHT46_RS08315	COG0778	Nitroreductase
DHT46_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS08330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DHT46_RS08345	COG0471	metal ion transport
DHT46_RS08350	COG1053	succinate dehydrogenase
DHT46_RS08350	COG0431	NADPH-dependent FMN reductase
DHT46_RS08350	COG3976	FMN-binding domain protein
DHT46_RS08370	COG1573	uracil-dna glycosylase
DHT46_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
DHT46_RS08390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DHT46_RS08395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHT46_RS08400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DHT46_RS08405	COG4853	Protein conserved in bacteria
DHT46_RS08415	COG5002	protein histidine kinase activity
DHT46_RS08420	COG0745	RESPONSE REGULATOR receiver
DHT46_RS08435	COG1278	Cold shock
DHT46_RS08445	COG1554	hydrolase, family 65, central catalytic
DHT46_RS08450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DHT46_RS08465	COG0058	SHG alpha-glucan phosphorylase activity
DHT46_RS08470	COG0297	glycogen (starch) synthase activity
DHT46_RS08475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DHT46_RS08480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DHT46_RS08485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DHT46_RS08490	COG4166	transmembrane transport
DHT46_RS08495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DHT46_RS08500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DHT46_RS08505	COG2814	Major facilitator Superfamily
DHT46_RS08510	COG0305	Participates in initiation and elongation during chromosome replication
DHT46_RS08515	COG0359	binds to the 23S rRNA
DHT46_RS08525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DHT46_RS08530	COG0629	single-stranded DNA binding
DHT46_RS08535	COG0360	Binds together with S18 to 16S ribosomal RNA
DHT46_RS08545	COG0187	DNA topoisomerase II activity
DHT46_RS08550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DHT46_RS08555	COG2501	S4 domain
DHT46_RS08560	COG0592	DNA-directed DNA polymerase activity
DHT46_RS08565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DHT46_RS08570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DHT46_RS08575	COG0594	ribonuclease P activity
DHT46_RS08580	COG0706	membrane insertase activity
DHT46_RS08585	COG1847	R3H domain protein
DHT46_RS08590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DHT46_RS08595	COG0445	tRNA wobble uridine modification
DHT46_RS08635	COG1307	EDD domain protein, DegV family
DHT46_RS08650	COG3479	Phenolic acid decarboxylase
DHT46_RS08655	COG1695	Transcriptional regulator
DHT46_RS08665	COG1012	belongs to the aldehyde dehydrogenase family
DHT46_RS08665	COG1454	alcohol dehydrogenase
DHT46_RS08670	COG1609	Transcriptional regulator
DHT46_RS08680	COG1869	D-ribose catabolic process
DHT46_RS08685	COG4975	Glucose uptake
DHT46_RS08705	COG3730	PTS system glucitol sorbitol-specific
DHT46_RS08710	COG3732	PTS system glucitol sorbitol-specific
DHT46_RS08720	COG0028	Belongs to the TPP enzyme family
DHT46_RS08725	COG1959	2 iron, 2 sulfur cluster binding
DHT46_RS08730	COG0028	Belongs to the TPP enzyme family
DHT46_RS08735	COG1304	FMN binding
DHT46_RS08750	COG4512	PFAM Accessory gene regulator B
DHT46_RS08770	COG1393	Belongs to the ArsC family
DHT46_RS08780	COG2261	transglycosylase associated protein
DHT46_RS08810	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DHT46_RS08815	COG1609	Transcriptional regulator
DHT46_RS08835	COG2160	L-arabinose isomerase activity
DHT46_RS08840	COG0110	maltose O-acetyltransferase activity
DHT46_RS08850	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DHT46_RS08855	COG1349	DNA-binding transcription factor activity
DHT46_RS08865	COG3414	Phosphotransferase system galactitol-specific IIB component
DHT46_RS08870	COG3775	system Galactitol-specific IIC component
DHT46_RS08885	COG3711	transcriptional antiterminator
DHT46_RS08905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DHT46_RS08920	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DHT46_RS08935	COG2211	Major facilitator Superfamily
DHT46_RS08955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS08955	COG1263	PTS System
DHT46_RS08955	COG2190	(PTS) system
DHT46_RS08960	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS08965	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS08970	COG3711	transcriptional antiterminator
DHT46_RS08980	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS08990	COG2971	BadF BadG BcrA BcrD
DHT46_RS08995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DHT46_RS09000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS09005	COG2188	Transcriptional regulator
DHT46_RS09010	COG2267	carboxylic ester hydrolase activity
DHT46_RS09020	COG2271	Major facilitator Superfamily
DHT46_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS09050	COG2271	Major facilitator Superfamily
DHT46_RS09055	COG0583	DNA-binding transcription factor activity
DHT46_RS09060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DHT46_RS09065	COG0710	3-dehydroquinate dehydratase activity
DHT46_RS09085	COG0667	Aldo Keto reductase
DHT46_RS09090	COG1609	Transcriptional regulator
DHT46_RS09095	COG2017	converts alpha-aldose to the beta-anomer
DHT46_RS09100	COG2211	Major facilitator Superfamily
DHT46_RS09100	COG2190	(PTS) system
DHT46_RS09120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DHT46_RS09125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DHT46_RS09130	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DHT46_RS09135	COG1609	Transcriptional regulator
DHT46_RS09140	COG2944	sequence-specific DNA binding
DHT46_RS09145	COG2184	nucleotidyltransferase activity
DHT46_RS09165	COG0477	Major facilitator Superfamily
DHT46_RS09175	COG1609	Transcriptional regulator
DHT46_RS09180	COG1874	Beta-galactosidase
DHT46_RS09190	COG1114	Component of the transport system for branched-chain amino acids
DHT46_RS09200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS09250	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS09270	COG3590	peptidase
DHT46_RS09275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DHT46_RS09295	COG1937	Protein conserved in bacteria
DHT46_RS09300	COG3118	belongs to the thioredoxin family
DHT46_RS09305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DHT46_RS09310	COG2217	Heavy metal translocating P-type atpase
DHT46_RS09330	COG2226	methyltransferase
DHT46_RS09340	COG1309	transcriptional regulator
DHT46_RS09390	COG0076	glutamate decarboxylase activity
DHT46_RS09415	COG2207	Transcriptional regulator
DHT46_RS09450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DHT46_RS09455	COG1968	undecaprenyl-diphosphatase activity
DHT46_RS09475	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS09485	COG0737	Belongs to the 5'-nucleotidase family
DHT46_RS09545	COG0477	Major facilitator Superfamily
DHT46_RS09570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DHT46_RS09585	COG0697	spore germination
DHT46_RS09605	COG0071	Belongs to the small heat shock protein (HSP20) family
DHT46_RS09620	COG1194	a g-specific adenine glycosylase
DHT46_RS09630	COG3189	MarR family transcriptional regulator
DHT46_RS09635	COG1393	Belongs to the ArsC family
DHT46_RS09650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DHT46_RS09660	COG1113	amino acid transport
DHT46_RS09665	COG1757	Na H antiporter
DHT46_RS09675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DHT46_RS09680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DHT46_RS09690	COG2315	Protein conserved in bacteria
DHT46_RS09700	COG2217	Heavy metal translocating P-type atpase
DHT46_RS09735	COG4989	oxidoreductase activity
DHT46_RS09740	COG2151	metal-sulfur cluster biosynthetic enzyme
DHT46_RS09750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DHT46_RS09755	COG1882	Formate acetyltransferase
DHT46_RS09760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DHT46_RS09790	COG2814	Major facilitator Superfamily
DHT46_RS09795	COG0803	Belongs to the bacterial solute-binding protein 9 family
DHT46_RS09815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DHT46_RS09820	COG0302	gtp cyclohydrolase
DHT46_RS09830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DHT46_RS09865	COG0640	Transcriptional regulator
DHT46_RS09870	COG1272	protein, Hemolysin III
DHT46_RS09885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DHT46_RS09890	COG0628	permease
DHT46_RS09895	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DHT46_RS09900	COG3158	transport of potassium into the cell
DHT46_RS09905	COG0531	amino acid
DHT46_RS09920	COG1511	domain protein
DHT46_RS09930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DHT46_RS09935	COG2365	Tyrosine phosphatase family
DHT46_RS09940	COG0516	GMP reductase activity
DHT46_RS09945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DHT46_RS09950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DHT46_RS09965	COG1929	Belongs to the glycerate kinase type-1 family
DHT46_RS09975	COG1562	ergosterol biosynthetic process
DHT46_RS09980	COG1233	COG1233 Phytoene dehydrogenase and related
DHT46_RS09985	COG2738	Putative neutral zinc metallopeptidase
DHT46_RS09995	COG1307	EDD domain protein, DegV family
DHT46_RS10005	COG1380	Effector of murein hydrolase LrgA
DHT46_RS10030	COG0735	belongs to the Fur family
DHT46_RS10075	COG3711	transcriptional antiterminator
DHT46_RS10075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS10080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS10080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS10080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS10085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS10090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS10090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS10090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS10095	COG0383	alpha-mannosidase activity
DHT46_RS10105	COG0561	phosphatase activity
DHT46_RS10120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DHT46_RS10125	COG4619	ABC transporter
DHT46_RS10130	COG0390	transport system, permease component
DHT46_RS10145	COG1609	Transcriptional regulator
DHT46_RS10150	COG0366	Alpha amylase catalytic
DHT46_RS10155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS10155	COG2190	(PTS) system
DHT46_RS10155	COG1263	PTS System
DHT46_RS10180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DHT46_RS10185	COG1126	abc transporter atp-binding protein
DHT46_RS10190	COG0765	amino acid transport
DHT46_RS10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DHT46_RS10200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DHT46_RS10205	COG0583	DNA-binding transcription factor activity
DHT46_RS10220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DHT46_RS10225	COG0357	Ribosomal RNA small subunit methyltransferase G
DHT46_RS10235	COG1192	Involved in chromosome partitioning
DHT46_RS10240	COG1475	DNA binding
DHT46_RS10245	COG4481	Protein conserved in bacteria
DHT46_RS10250	COG0012	GTP binding
DHT46_RS10260	COG0516	GMP reductase activity
DHT46_RS10260	COG0517	IMP dehydrogenase activity
DHT46_RS10265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DHT46_RS10285	COG1686	Belongs to the peptidase S11 family
DHT46_RS10290	COG1247	-acetyltransferase
DHT46_RS10330	COG2815	serine threonine protein kinase
DHT46_RS10330	COG0515	serine threonine protein kinase
DHT46_RS10340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DHT46_RS10350	COG1940	carbohydrate kinase activity
DHT46_RS10350	COG1846	Transcriptional regulator
DHT46_RS10355	COG0628	permease
DHT46_RS10360	COG0588	phosphoglycerate mutase activity
DHT46_RS10365	COG2226	methyltransferase
DHT46_RS10375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DHT46_RS10385	COG1511	domain protein
DHT46_RS10410	COG2801	Transposase and inactivated derivatives
DHT46_RS10555	COG0477	Major facilitator Superfamily
DHT46_RS10570	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS10575	COG1376	ErfK ybiS ycfS ynhG family protein
DHT46_RS10595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DHT46_RS10605	COG1136	(ABC) transporter
DHT46_RS10605	COG0577	efflux transmembrane transporter activity
DHT46_RS10630	COG0693	protein deglycase activity
DHT46_RS10645	COG3711	transcriptional antiterminator
DHT46_RS10670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS10670	COG1263	PTS System
DHT46_RS10670	COG2190	(PTS) system
DHT46_RS10675	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS10695	COG0783	Belongs to the Dps family
DHT46_RS10705	COG3976	FMN-binding domain protein
DHT46_RS10705	COG0431	NADPH-dependent FMN reductase
DHT46_RS10705	COG1053	succinate dehydrogenase
DHT46_RS10715	COG2816	NAD+ diphosphatase activity
DHT46_RS10725	COG0481	GTPase activity
DHT46_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS10770	COG0110	maltose O-acetyltransferase activity
DHT46_RS10775	COG4221	oxidoreductase activity
DHT46_RS10785	COG1309	transcriptional regulator
DHT46_RS10790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DHT46_RS10795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DHT46_RS10800	COG1120	ATPase activity
DHT46_RS10805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DHT46_RS10815	COG0477	Major facilitator Superfamily
DHT46_RS10820	COG4989	oxidoreductase activity
DHT46_RS10840	COG0300	oxidoreductase activity
DHT46_RS10845	COG1733	regulation of RNA biosynthetic process
DHT46_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
DHT46_RS10870	COG1309	transcriptional regulator
DHT46_RS10885	COG3279	Response regulator of the LytR AlgR family
DHT46_RS10890	COG0367	asparagine synthase
DHT46_RS10900	COG2814	Major facilitator Superfamily
DHT46_RS10905	COG1733	regulation of RNA biosynthetic process
DHT46_RS10910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DHT46_RS10950	COG1063	alcohol dehydrogenase
DHT46_RS11010	COG2217	Heavy metal translocating P-type atpase
DHT46_RS11040	COG0531	amino acid
DHT46_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS11060	COG1473	amidohydrolase
DHT46_RS11070	COG1132	(ABC) transporter
DHT46_RS11075	COG1132	(ABC) transporter
DHT46_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS11120	COG4221	oxidoreductase activity
DHT46_RS11135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DHT46_RS11160	COG0803	Belongs to the bacterial solute-binding protein 9 family
DHT46_RS11180	COG0741	lytic transglycosylase activity
DHT46_RS11185	COG0789	Transcriptional regulator
DHT46_RS11195	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS11200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS11205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS11245	COG0577	efflux transmembrane transporter activity
DHT46_RS11245	COG1136	(ABC) transporter
DHT46_RS11260	COG0640	Transcriptional regulator
DHT46_RS11280	COG1914	H( )-stimulated, divalent metal cation uptake system
DHT46_RS11290	COG2246	polysaccharide biosynthetic process
DHT46_RS11295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHT46_RS11295	COG5549	protein import
DHT46_RS11310	COG0559	Belongs to the binding-protein-dependent transport system permease family
DHT46_RS11325	COG0410	ABC transporter
DHT46_RS11330	COG3620	sequence-specific DNA binding
DHT46_RS11330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DHT46_RS11330	COG0617	tRNA 3'-terminal CCA addition
DHT46_RS11360	COG4120	Belongs to the binding-protein-dependent transport system permease family
DHT46_RS11365	COG1116	anion transmembrane transporter activity
DHT46_RS11370	COG1263	PTS System
DHT46_RS11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS11370	COG2190	(PTS) system
DHT46_RS11375	COG0778	Nitroreductase
DHT46_RS11385	COG1132	(ABC) transporter
DHT46_RS11390	COG1940	carbohydrate kinase activity
DHT46_RS11415	COG0697	spore germination
DHT46_RS11470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DHT46_RS11480	COG0583	DNA-binding transcription factor activity
DHT46_RS11500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DHT46_RS11510	COG0242	peptide deformylase activity
DHT46_RS11520	COG1328	CTP reductase activity
DHT46_RS11530	COG2200	EAL domain
DHT46_RS11570	COG2270	Major facilitator Superfamily
DHT46_RS11575	COG0531	amino acid
DHT46_RS11580	COG2267	carboxylic ester hydrolase activity
DHT46_RS11595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DHT46_RS11605	COG0561	phosphatase activity
DHT46_RS11610	COG0488	(ABC) transporter
DHT46_RS11640	COG0640	Transcriptional regulator
DHT46_RS11650	COG1511	domain protein
DHT46_RS11650	COG1511	domain protein
DHT46_RS11665	COG2814	Major facilitator Superfamily
DHT46_RS11670	COG1132	(ABC) transporter
DHT46_RS11675	COG1132	(ABC) transporter
DHT46_RS11680	COG0667	Aldo Keto reductase
DHT46_RS11690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DHT46_RS11705	COG1011	Hydrolase
DHT46_RS11710	COG0110	maltose O-acetyltransferase activity
DHT46_RS11715	COG0589	response to stress
DHT46_RS11725	COG1396	sequence-specific DNA binding
DHT46_RS11755	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS11760	COG4221	oxidoreductase activity
DHT46_RS11780	COG0583	DNA-binding transcription factor activity
DHT46_RS11785	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS11795	COG4975	Glucose uptake
DHT46_RS11815	COG0656	L-ascorbic acid biosynthetic process
DHT46_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
DHT46_RS11825	COG1063	alcohol dehydrogenase
DHT46_RS11835	COG0583	DNA-binding transcription factor activity
DHT46_RS11860	COG0456	acetyltransferase
DHT46_RS11885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DHT46_RS11905	COG0789	Transcriptional regulator
DHT46_RS11920	COG4221	oxidoreductase activity
DHT46_RS11930	COG4152	abc transporter atp-binding protein
DHT46_RS11950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DHT46_RS11965	COG0438	transferase activity, transferring glycosyl groups
DHT46_RS11975	COG0583	DNA-binding transcription factor activity
DHT46_RS11980	COG2855	membrane
DHT46_RS11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DHT46_RS11995	COG2814	Major facilitator Superfamily
DHT46_RS12045	COG1136	(ABC) transporter
DHT46_RS12050	COG0577	efflux transmembrane transporter activity
DHT46_RS12070	COG1811	Na channel or pump
DHT46_RS12095	COG4990	cell redox homeostasis
DHT46_RS12110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DHT46_RS12115	COG4720	Psort location CytoplasmicMembrane, score
DHT46_RS12160	COG0531	amino acid
DHT46_RS12165	COG0710	3-dehydroquinate dehydratase activity
DHT46_RS12185	COG0716	FMN binding
DHT46_RS12210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DHT46_RS12215	COG0561	phosphatase activity
DHT46_RS12230	COG1216	Glycosyl transferase, family 2
DHT46_RS12235	COG2188	Transcriptional regulator
DHT46_RS12240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DHT46_RS12245	COG1447	Phosphotransferase system cellobiose-specific component IIA
DHT46_RS12250	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS12255	COG2723	6-phospho-beta-galactosidase activity
DHT46_RS12260	COG3048	D-serine ammonia-lyase activity
DHT46_RS12265	COG1131	(ABC) transporter
DHT46_RS12275	COG1309	transcriptional regulator
DHT46_RS12280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DHT46_RS12285	COG1827	regulation of RNA biosynthetic process
DHT46_RS12320	COG0494	nUDIX hydrolase
DHT46_RS12325	COG0110	maltose O-acetyltransferase activity
DHT46_RS12335	COG0561	phosphatase activity
DHT46_RS12345	COG0366	Alpha amylase catalytic
DHT46_RS12365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DHT46_RS12385	COG2246	polysaccharide biosynthetic process
DHT46_RS12395	COG0589	response to stress
DHT46_RS12405	COG1131	(ABC) transporter
DHT46_RS12410	COG1725	Transcriptional regulator
DHT46_RS12425	COG1136	(ABC) transporter
DHT46_RS12445	COG2365	Tyrosine phosphatase family
DHT46_RS12450	COG0095	Lipoate-protein ligase
DHT46_RS12455	COG1053	succinate dehydrogenase
DHT46_RS12455	COG0431	NADPH-dependent FMN reductase
DHT46_RS12455	COG3976	FMN-binding domain protein
DHT46_RS12460	COG1053	succinate dehydrogenase
DHT46_RS12460	COG3976	FMN-binding domain protein
DHT46_RS12460	COG0431	NADPH-dependent FMN reductase
DHT46_RS12470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DHT46_RS12475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DHT46_RS12480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DHT46_RS12485	COG0047	phosphoribosylformylglycinamidine synthase activity
DHT46_RS12490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DHT46_RS12500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DHT46_RS12505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DHT46_RS12510	COG0138	bifunctional purine biosynthesis protein purh
DHT46_RS12515	COG0151	Belongs to the GarS family
DHT46_RS12525	COG1215	transferase activity, transferring glycosyl groups
DHT46_RS12545	COG2252	PERMEase
DHT46_RS12550	COG2233	PERMEase
DHT46_RS12555	COG2508	Transcriptional regulator
DHT46_RS12560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DHT46_RS12565	COG0540	Belongs to the ATCase OTCase family
DHT46_RS12570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DHT46_RS12575	COG0505	Belongs to the CarA family
DHT46_RS12585	COG0167	dihydroorotate dehydrogenase activity
DHT46_RS12590	COG0284	orotidine-5'-phosphate decarboxylase activity
DHT46_RS12595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DHT46_RS12605	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DHT46_RS12610	COG1074	ATP-dependent DNA helicase activity
DHT46_RS12620	COG0702	epimerase
DHT46_RS12625	COG0583	DNA-binding transcription factor activity
DHT46_RS12640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DHT46_RS12645	COG0436	Aminotransferase
DHT46_RS12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DHT46_RS12660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DHT46_RS12670	COG0604	alcohol dehydrogenase
DHT46_RS12675	COG0789	Transcriptional regulator
DHT46_RS12680	COG2814	Major facilitator Superfamily
DHT46_RS12685	COG0025	NhaP-type Na H and K H
DHT46_RS12690	COG1780	Probably involved in ribonucleotide reductase function
DHT46_RS12695	COG1253	flavin adenine dinucleotide binding
DHT46_RS12725	COG1418	mRNA catabolic process
DHT46_RS12735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DHT46_RS12740	COG2188	Transcriptional regulator
DHT46_RS12750	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DHT46_RS12765	COG1396	sequence-specific DNA binding
DHT46_RS12770	COG4640	response to antibiotic
DHT46_RS12785	COG0564	pseudouridine synthase activity
DHT46_RS12790	COG0589	response to stress
DHT46_RS12795	COG1705	Flagellar rod assembly protein muramidase FlgJ
DHT46_RS12800	COG0095	Lipoate-protein ligase
DHT46_RS12830	COG0626	cystathionine gamma-synthase activity
DHT46_RS12835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DHT46_RS12840	COG1073	alpha beta
DHT46_RS12850	COG0028	Belongs to the TPP enzyme family
DHT46_RS12905	COG1725	Transcriptional regulator
DHT46_RS12910	COG1131	(ABC) transporter
DHT46_RS12920	COG1335	isochorismatase
DHT46_RS12930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DHT46_RS12940	COG0673	inositol 2-dehydrogenase activity
DHT46_RS12945	COG0673	inositol 2-dehydrogenase activity
DHT46_RS12955	COG1609	Transcriptional regulator
DHT46_RS12965	COG0328	RNA-DNA hybrid ribonuclease activity
DHT46_RS12975	COG0778	Nitroreductase
DHT46_RS12980	COG2326	polyphosphate kinase activity
DHT46_RS12995	COG0492	ferredoxin-NADP+ reductase activity
DHT46_RS13005	COG0584	glycerophosphoryl diester phosphodiesterase
DHT46_RS13010	COG1368	sulfuric ester hydrolase activity
DHT46_RS13030	COG3548	integral membrane protein
DHT46_RS13045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DHT46_RS13055	COG0300	oxidoreductase activity
DHT46_RS13060	COG0789	Transcriptional regulator
DHT46_RS13080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DHT46_RS13085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DHT46_RS13090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DHT46_RS13095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DHT46_RS13100	COG0131	Imidazoleglycerol-phosphate dehydratase
DHT46_RS13105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DHT46_RS13110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DHT46_RS13115	COG0107	imidazoleglycerol-phosphate synthase activity
DHT46_RS13120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DHT46_RS13125	COG0140	phosphoribosyl-ATP diphosphatase activity
DHT46_RS13130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DHT46_RS13135	COG0110	maltose O-acetyltransferase activity
DHT46_RS13140	COG0861	Integral membrane protein TerC family
DHT46_RS13145	COG2084	Dehydrogenase
DHT46_RS13150	COG0446	pyridine nucleotide-disulphide oxidoreductase
DHT46_RS13160	COG4120	Belongs to the binding-protein-dependent transport system permease family
DHT46_RS13175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DHT46_RS13180	COG2873	o-acetylhomoserine
DHT46_RS13190	COG1307	EDD domain protein, DegV family
DHT46_RS13195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DHT46_RS13200	COG1263	PTS System
DHT46_RS13200	COG2190	(PTS) system
DHT46_RS13200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS13230	COG0488	(ABC) transporter
DHT46_RS13250	COG1522	sequence-specific DNA binding
DHT46_RS13255	COG0791	NLP P60 protein
DHT46_RS13275	COG0477	Major facilitator Superfamily
DHT46_RS13300	COG3830	Belongs to the UPF0237 family
DHT46_RS13305	COG2848	UPF0210 protein
DHT46_RS13310	COG0745	RESPONSE REGULATOR receiver
DHT46_RS13315	COG3850	Histidine kinase
DHT46_RS13315	COG5002	protein histidine kinase activity
DHT46_RS13320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DHT46_RS13325	COG4975	Glucose uptake
DHT46_RS13330	COG0166	Belongs to the GPI family
DHT46_RS13340	COG1136	(ABC) transporter
DHT46_RS13340	COG0577	efflux transmembrane transporter activity
DHT46_RS13350	COG1132	(ABC) transporter
DHT46_RS13395	COG4932	domain protein
DHT46_RS13395	COG4886	Leucine-rich repeat (LRR) protein
DHT46_RS13420	COG4974	Belongs to the 'phage' integrase family
DHT46_RS13490	COG4695	Portal protein
DHT46_RS13810	COG5434	Belongs to the glycosyl hydrolase 28 family
DHT46_RS13855	COG0726	polysaccharide deacetylase
DHT46_RS13870	COG1132	(ABC) transporter
DHT46_RS13885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DHT46_RS13895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DHT46_RS13900	COG1482	cell wall glycoprotein biosynthetic process
DHT46_RS13905	COG3442	glutamine amidotransferase
DHT46_RS13910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DHT46_RS13915	COG1435	thymidine kinase activity
DHT46_RS13920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DHT46_RS13925	COG2890	protein-(glutamine-N5) methyltransferase activity
DHT46_RS13930	COG0009	L-threonylcarbamoyladenylate synthase
DHT46_RS13935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DHT46_RS13940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DHT46_RS13950	COG2233	PERMEase
DHT46_RS13955	COG0356	it plays a direct role in the translocation of protons across the membrane
DHT46_RS13960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DHT46_RS13965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DHT46_RS13970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DHT46_RS13975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DHT46_RS13980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DHT46_RS13985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DHT46_RS13990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DHT46_RS13995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DHT46_RS14005	COG1077	Cell shape determining protein MreB Mrl
DHT46_RS14010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DHT46_RS14020	COG0772	Belongs to the SEDS family
DHT46_RS14025	COG0509	glycine decarboxylation via glycine cleavage system
DHT46_RS14030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DHT46_RS14035	COG2011	ABC-type metal ion transport system permease component
DHT46_RS14040	COG1464	Belongs to the NlpA lipoprotein family
DHT46_RS14060	COG1181	Belongs to the D-alanine--D-alanine ligase family
DHT46_RS14080	COG0589	response to stress
DHT46_RS14095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DHT46_RS14100	COG0189	ligase activity
DHT46_RS14100	COG2918	glutathione biosynthetic process
DHT46_RS14105	COG1609	Transcriptional regulator
DHT46_RS14110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DHT46_RS14115	COG3715	PTS system
DHT46_RS14120	COG3716	PTS system mannose fructose sorbose family IID component
DHT46_RS14130	COG0366	Alpha amylase catalytic
DHT46_RS14135	COG0640	Transcriptional regulator
DHT46_RS14150	COG4493	Belongs to the UPF0637 family
DHT46_RS14155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DHT46_RS14160	COG1956	GAF domain-containing protein
DHT46_RS14165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DHT46_RS14175	COG1104	cysteine desulfurase activity
DHT46_RS14180	COG0301	tRNA thio-modification
DHT46_RS14185	COG1181	Belongs to the D-alanine--D-alanine ligase family
DHT46_RS14185	COG2918	glutathione biosynthetic process
DHT46_RS14195	COG0525	valine-tRNA ligase activity
DHT46_RS14200	COG0285	dihydrofolate synthase activity
DHT46_RS14205	COG2003	Belongs to the UPF0758 family
DHT46_RS14210	COG1077	Cell shape determining protein MreB Mrl
DHT46_RS14215	COG1792	Involved in formation and maintenance of cell shape
DHT46_RS14225	COG0850	regulation of cytokinetic process
DHT46_RS14230	COG2894	cell division
DHT46_RS14235	COG0765	amino acid transport
DHT46_RS14240	COG1126	abc transporter atp-binding protein
DHT46_RS14245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DHT46_RS14260	COG0527	aspartate kinase activity
DHT46_RS14265	COG0612	Peptidase, M16
DHT46_RS14270	COG0612	Peptidase, M16
DHT46_RS14275	COG1426	Protein conserved in bacteria
DHT46_RS14280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DHT46_RS14285	COG1546	Belongs to the CinA family
DHT46_RS14285	COG1058	Belongs to the CinA family
DHT46_RS14290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DHT46_RS14295	COG1418	mRNA catabolic process
DHT46_RS14300	COG1692	metallophosphoesterase
DHT46_RS14305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DHT46_RS14310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DHT46_RS14340	COG0632	four-way junction helicase activity
DHT46_RS14345	COG2255	four-way junction helicase activity
DHT46_RS14350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DHT46_RS14355	COG0343	queuine tRNA-ribosyltransferase activity
DHT46_RS14360	COG1862	Preprotein translocase
DHT46_RS14365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DHT46_RS14370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DHT46_RS14375	COG0513	Belongs to the DEAD box helicase family
DHT46_RS14380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DHT46_RS14385	COG4472	Bacterial protein of unknown function (DUF965)
DHT46_RS14390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DHT46_RS14395	COG3906	Belongs to the UPF0473 family
DHT46_RS14405	COG1193	negative regulation of DNA recombination
DHT46_RS14410	COG3118	belongs to the thioredoxin family
DHT46_RS14415	COG1719	4-vinyl reductase, 4VR
DHT46_RS14420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DHT46_RS14425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DHT46_RS14435	COG0517	IMP dehydrogenase activity
DHT46_RS14440	COG2171	N-acyltransferase activity
DHT46_RS14445	COG1473	amidohydrolase
DHT46_RS14450	COG0668	transmembrane transport
DHT46_RS14465	COG0789	Transcriptional regulator
DHT46_RS14470	COG0006	proline dipeptidase activity
DHT46_RS14475	COG1609	Transcriptional regulator
DHT46_RS14490	COG0217	transcriptional regulatory protein
DHT46_RS14500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DHT46_RS14530	COG0827	DNA restriction-modification system
DHT46_RS14535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DHT46_RS14540	COG1113	amino acid transport
DHT46_RS14555	COG0737	Belongs to the 5'-nucleotidase family
DHT46_RS14560	COG4470	Protein conserved in bacteria
DHT46_RS14565	COG0647	UMP catabolic process
DHT46_RS14575	COG0586	Pfam SNARE associated Golgi protein
DHT46_RS14585	COG1098	S1 RNA binding domain
DHT46_RS14725	COG1234	tRNA 3'-trailer cleavage
DHT46_RS14730	COG1393	Belongs to the ArsC family
DHT46_RS14735	COG4862	establishment of competence for transformation
DHT46_RS14755	COG2357	RelA SpoT domain protein
DHT46_RS14760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DHT46_RS14765	COG0564	pseudouridine synthase activity
DHT46_RS14770	COG3142	Participates in the control of copper homeostasis
DHT46_RS14775	COG2706	6-phosphogluconolactonase activity
DHT46_RS14785	COG0628	permease
DHT46_RS14790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DHT46_RS14800	COG1114	Component of the transport system for branched-chain amino acids
DHT46_RS14810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DHT46_RS14815	COG1674	ftsk spoiiie
DHT46_RS14835	COG2001	Belongs to the MraZ family
DHT46_RS14840	COG0275	rRNA processing
DHT46_RS14850	COG0768	penicillin binding
DHT46_RS14855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DHT46_RS14860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DHT46_RS14865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DHT46_RS14870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DHT46_RS14885	COG1799	cell septum assembly
DHT46_RS14890	COG0762	integral membrane protein
DHT46_RS14900	COG3599	regulation of cell shape
DHT46_RS14905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DHT46_RS14910	COG1131	(ABC) transporter
DHT46_RS14920	COG3279	Response regulator of the LytR AlgR family
DHT46_RS14930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DHT46_RS14935	COG0494	nUDIX hydrolase
DHT46_RS14945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DHT46_RS14950	COG1104	cysteine desulfurase activity
DHT46_RS14960	COG0482	sulfurtransferase activity
DHT46_RS14965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DHT46_RS14970	COG0569	domain protein
DHT46_RS15000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DHT46_RS15005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DHT46_RS15010	COG1388	LysM domain
DHT46_RS15010	COG3584	3D domain protein
DHT46_RS15020	COG1597	lipid kinase activity
DHT46_RS15025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DHT46_RS15030	COG5503	Protein of unknown function (DUF1447)
DHT46_RS15040	COG0242	peptide deformylase activity
DHT46_RS15065	COG0039	L-malate dehydrogenase activity
DHT46_RS15070	COG4476	Belongs to the UPF0223 family
DHT46_RS15075	COG0483	inositol monophosphate 1-phosphatase activity
DHT46_RS15080	COG1217	gtp-binding protein TYPA
DHT46_RS15120	COG0772	Belongs to the SEDS family
DHT46_RS15125	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DHT46_RS15130	COG4471	UPF0298 protein
DHT46_RS15135	COG0742	ribosomal rna small subunit methyltransferase
DHT46_RS15140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DHT46_RS15145	COG3480	Lon protease (S16) C-terminal proteolytic domain
DHT46_RS15150	COG1555	photosystem II stabilization
DHT46_RS15150	COG1596	polysaccharide export
DHT46_RS15155	COG2131	deaminase
DHT46_RS15160	COG0658	competence protein
DHT46_RS15160	COG2333	competence protein COMEC
DHT46_RS15165	COG1466	dna polymerase III delta subunit
DHT46_RS15170	COG0268	Binds directly to 16S ribosomal RNA
DHT46_RS15175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DHT46_RS15200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DHT46_RS15205	COG0544	peptidyl-prolyl cis-trans isomerase activity
DHT46_RS15210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DHT46_RS15215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DHT46_RS15235	COG0765	amino acid transport
DHT46_RS15240	COG1126	abc transporter atp-binding protein
DHT46_RS15245	COG0322	excinuclease ABC activity
DHT46_RS15255	COG0489	protein tyrosine kinase activity
DHT46_RS15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DHT46_RS15270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DHT46_RS15275	COG0297	glycogen (starch) synthase activity
DHT46_RS15300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DHT46_RS15305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS15305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DHT46_RS15305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DHT46_RS15310	COG1105	Belongs to the carbohydrate kinase PfkB family
DHT46_RS15315	COG1349	DNA-binding transcription factor activity
DHT46_RS15320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DHT46_RS15330	COG1234	tRNA 3'-trailer cleavage
DHT46_RS15335	COG0300	oxidoreductase activity
DHT46_RS15340	COG5416	Lipopolysaccharide assembly protein A domain
DHT46_RS15345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DHT46_RS15345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DHT46_RS15350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DHT46_RS15365	COG0393	Putative heavy-metal-binding
DHT46_RS15535	COG2801	Transposase and inactivated derivatives
DHT46_RS15545	COG2217	Heavy metal translocating P-type atpase
DHT46_RS15560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DHT46_RS15570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DHT46_RS15600	COG0446	pyridine nucleotide-disulphide oxidoreductase