locus-tag	class	description
Heal19_RS00050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Heal19_RS00130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Heal19_RS00145	COG0860	N-Acetylmuramoyl-L-alanine amidase
Heal19_RS00155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Heal19_RS00160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Heal19_RS00170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Heal19_RS00205	COG1268	BioY protein
Heal19_RS00215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Heal19_RS00225	COG1307	EDD domain protein, DegV family
Heal19_RS00230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Heal19_RS00235	COG3875	lactate racemase activity
Heal19_RS00240	COG1691	(AIR) carboxylase
Heal19_RS00245	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Heal19_RS00250	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Heal19_RS00255	COG1606	tRNA processing
Heal19_RS00260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS00295	COG1192	Involved in chromosome partitioning
Heal19_RS00390	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Heal19_RS00410	COG1914	H( )-stimulated, divalent metal cation uptake system
Heal19_RS00430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Heal19_RS00435	COG1307	EDD domain protein, DegV family
Heal19_RS00455	COG1215	transferase activity, transferring glycosyl groups
Heal19_RS00475	COG2814	Major facilitator Superfamily
Heal19_RS00480	COG1132	(ABC) transporter
Heal19_RS00485	COG1132	(ABC) transporter
Heal19_RS00490	COG0667	Aldo Keto reductase
Heal19_RS00500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Heal19_RS00515	COG1011	Hydrolase
Heal19_RS00520	COG0110	maltose O-acetyltransferase activity
Heal19_RS00525	COG0589	response to stress
Heal19_RS00535	COG1396	sequence-specific DNA binding
Heal19_RS00560	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS00565	COG4221	oxidoreductase activity
Heal19_RS00585	COG0583	DNA-binding transcription factor activity
Heal19_RS00590	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS00600	COG4975	Glucose uptake
Heal19_RS00620	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS00630	COG1063	alcohol dehydrogenase
Heal19_RS00640	COG0583	DNA-binding transcription factor activity
Heal19_RS00665	COG0456	acetyltransferase
Heal19_RS00685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Heal19_RS00710	COG0789	Transcriptional regulator
Heal19_RS00725	COG4221	oxidoreductase activity
Heal19_RS00735	COG4152	abc transporter atp-binding protein
Heal19_RS00740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Heal19_RS00755	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS00775	COG0583	DNA-binding transcription factor activity
Heal19_RS00780	COG2855	membrane
Heal19_RS00795	COG2814	Major facilitator Superfamily
Heal19_RS00805	COG2814	Major facilitator Superfamily
Heal19_RS00845	COG1136	(ABC) transporter
Heal19_RS00850	COG0577	efflux transmembrane transporter activity
Heal19_RS00870	COG1811	Na channel or pump
Heal19_RS00885	COG4990	cell redox homeostasis
Heal19_RS00900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Heal19_RS00905	COG4720	Psort location CytoplasmicMembrane, score
Heal19_RS00950	COG0531	amino acid
Heal19_RS00955	COG0710	3-dehydroquinate dehydratase activity
Heal19_RS00975	COG0716	FMN binding
Heal19_RS01000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Heal19_RS01005	COG0561	phosphatase activity
Heal19_RS01020	COG1216	Glycosyl transferase, family 2
Heal19_RS01025	COG2188	Transcriptional regulator
Heal19_RS01030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS01035	COG1447	Phosphotransferase system cellobiose-specific component IIA
Heal19_RS01040	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS01045	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS01050	COG3048	D-serine ammonia-lyase activity
Heal19_RS01060	COG1131	(ABC) transporter
Heal19_RS01070	COG1309	transcriptional regulator
Heal19_RS01075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Heal19_RS01080	COG1827	regulation of RNA biosynthetic process
Heal19_RS01115	COG1051	belongs to the nudix hydrolase family
Heal19_RS01120	COG0110	maltose O-acetyltransferase activity
Heal19_RS01130	COG0561	phosphatase activity
Heal19_RS01140	COG0366	Alpha amylase catalytic
Heal19_RS01160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Heal19_RS01175	COG2246	polysaccharide biosynthetic process
Heal19_RS01185	COG0589	response to stress
Heal19_RS01195	COG1131	(ABC) transporter
Heal19_RS01200	COG1725	Transcriptional regulator
Heal19_RS01215	COG1136	(ABC) transporter
Heal19_RS01235	COG2365	Tyrosine phosphatase family
Heal19_RS01240	COG0095	Lipoate-protein ligase
Heal19_RS01245	COG1053	succinate dehydrogenase
Heal19_RS01245	COG3976	FMN-binding domain protein
Heal19_RS01245	COG0431	NADPH-dependent FMN reductase
Heal19_RS01250	COG3976	FMN-binding domain protein
Heal19_RS01250	COG0431	NADPH-dependent FMN reductase
Heal19_RS01250	COG1053	succinate dehydrogenase
Heal19_RS01260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Heal19_RS01265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Heal19_RS01270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Heal19_RS01275	COG0047	phosphoribosylformylglycinamidine synthase activity
Heal19_RS01280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Heal19_RS01290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Heal19_RS01295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Heal19_RS01300	COG0138	bifunctional purine biosynthesis protein purh
Heal19_RS01305	COG0151	Belongs to the GarS family
Heal19_RS01315	COG1215	transferase activity, transferring glycosyl groups
Heal19_RS01335	COG2252	PERMEase
Heal19_RS01340	COG2233	PERMEase
Heal19_RS01345	COG2508	Transcriptional regulator
Heal19_RS01350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Heal19_RS01355	COG0540	Belongs to the ATCase OTCase family
Heal19_RS01360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Heal19_RS01365	COG0505	Belongs to the CarA family
Heal19_RS01370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Heal19_RS01375	COG0167	dihydroorotate dehydrogenase activity
Heal19_RS01380	COG0284	orotidine-5'-phosphate decarboxylase activity
Heal19_RS01385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Heal19_RS01395	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Heal19_RS01400	COG1074	ATP-dependent DNA helicase activity
Heal19_RS01410	COG0702	epimerase
Heal19_RS01415	COG0583	DNA-binding transcription factor activity
Heal19_RS01430	COG0436	Aminotransferase
Heal19_RS01435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Heal19_RS01440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Heal19_RS01450	COG0604	alcohol dehydrogenase
Heal19_RS01455	COG0789	Transcriptional regulator
Heal19_RS01460	COG2814	Major facilitator Superfamily
Heal19_RS01465	COG0025	NhaP-type Na H and K H
Heal19_RS01470	COG1780	Probably involved in ribonucleotide reductase function
Heal19_RS01475	COG1253	flavin adenine dinucleotide binding
Heal19_RS01505	COG1418	mRNA catabolic process
Heal19_RS01515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Heal19_RS01520	COG2188	Transcriptional regulator
Heal19_RS01530	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Heal19_RS01545	COG1396	sequence-specific DNA binding
Heal19_RS01550	COG0564	pseudouridine synthase activity
Heal19_RS01555	COG0589	response to stress
Heal19_RS01560	COG2188	Transcriptional regulator
Heal19_RS01565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS01570	COG3715	PTS system
Heal19_RS01575	COG3716	PTS system mannose fructose sorbose family IID component
Heal19_RS01585	COG1705	Flagellar rod assembly protein muramidase FlgJ
Heal19_RS01590	COG0095	Lipoate-protein ligase
Heal19_RS01620	COG0626	cystathionine gamma-synthase activity
Heal19_RS01625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Heal19_RS01630	COG1073	alpha beta
Heal19_RS01640	COG0028	Belongs to the TPP enzyme family
Heal19_RS01680	COG1725	Transcriptional regulator
Heal19_RS01685	COG1131	(ABC) transporter
Heal19_RS01700	COG1335	isochorismatase
Heal19_RS01705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Heal19_RS01710	COG0025	NhaP-type Na H and K H
Heal19_RS01715	COG0673	inositol 2-dehydrogenase activity
Heal19_RS01720	COG0673	inositol 2-dehydrogenase activity
Heal19_RS01725	COG1737	Transcriptional regulator
Heal19_RS01730	COG1609	Transcriptional regulator
Heal19_RS01750	COG1882	Formate acetyltransferase
Heal19_RS01755	COG1349	DNA-binding transcription factor activity
Heal19_RS01765	COG1940	carbohydrate kinase activity
Heal19_RS01770	COG4975	Glucose uptake
Heal19_RS01775	COG0328	RNA-DNA hybrid ribonuclease activity
Heal19_RS01785	COG0778	Nitroreductase
Heal19_RS01790	COG2326	polyphosphate kinase activity
Heal19_RS01795	COG4932	domain protein
Heal19_RS01805	COG0492	ferredoxin-NADP+ reductase activity
Heal19_RS01810	COG0584	glycerophosphoryl diester phosphodiesterase
Heal19_RS01815	COG1368	sulfuric ester hydrolase activity
Heal19_RS01835	COG3548	integral membrane protein
Heal19_RS01850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Heal19_RS01860	COG0300	oxidoreductase activity
Heal19_RS01865	COG0789	Transcriptional regulator
Heal19_RS01885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Heal19_RS01890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Heal19_RS01895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Heal19_RS01900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Heal19_RS01905	COG0131	Imidazoleglycerol-phosphate dehydratase
Heal19_RS01910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Heal19_RS01915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Heal19_RS01920	COG0107	imidazoleglycerol-phosphate synthase activity
Heal19_RS01925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Heal19_RS01930	COG0140	phosphoribosyl-ATP diphosphatase activity
Heal19_RS01935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Heal19_RS01940	COG0110	maltose O-acetyltransferase activity
Heal19_RS01945	COG0861	Integral membrane protein TerC family
Heal19_RS01950	COG2084	Dehydrogenase
Heal19_RS01955	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS01965	COG4120	Belongs to the binding-protein-dependent transport system permease family
Heal19_RS01975	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Heal19_RS01980	COG2873	o-acetylhomoserine
Heal19_RS01990	COG1307	EDD domain protein, DegV family
Heal19_RS01995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Heal19_RS02000	COG2190	(PTS) system
Heal19_RS02000	COG1263	PTS System
Heal19_RS02000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS02020	COG0488	(ABC) transporter
Heal19_RS02025	COG3706	GGDEF domain
Heal19_RS02040	COG1522	sequence-specific DNA binding
Heal19_RS02045	COG0791	NLP P60 protein
Heal19_RS02065	COG0477	Major facilitator Superfamily
Heal19_RS02090	COG3830	Belongs to the UPF0237 family
Heal19_RS02095	COG2848	UPF0210 protein
Heal19_RS02100	COG0745	RESPONSE REGULATOR receiver
Heal19_RS02105	COG5002	protein histidine kinase activity
Heal19_RS02105	COG3850	Histidine kinase
Heal19_RS02110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Heal19_RS02115	COG4975	Glucose uptake
Heal19_RS02120	COG0166	Belongs to the GPI family
Heal19_RS02130	COG0577	efflux transmembrane transporter activity
Heal19_RS02130	COG1136	(ABC) transporter
Heal19_RS02140	COG1132	(ABC) transporter
Heal19_RS02155	COG4886	Leucine-rich repeat (LRR) protein
Heal19_RS02155	COG4932	domain protein
Heal19_RS02225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Heal19_RS02445	COG3953	SLT domain
Heal19_RS02445	COG5280	Phage tail tape measure protein TP901
Heal19_RS02485	COG0726	polysaccharide deacetylase
Heal19_RS02500	COG1132	(ABC) transporter
Heal19_RS02515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Heal19_RS02525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Heal19_RS02530	COG1482	cell wall glycoprotein biosynthetic process
Heal19_RS02535	COG3442	glutamine amidotransferase
Heal19_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Heal19_RS02545	COG1435	thymidine kinase activity
Heal19_RS02550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Heal19_RS02555	COG2890	protein-(glutamine-N5) methyltransferase activity
Heal19_RS02560	COG0009	L-threonylcarbamoyladenylate synthase
Heal19_RS02565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Heal19_RS02570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Heal19_RS02580	COG2233	PERMEase
Heal19_RS02585	COG0356	it plays a direct role in the translocation of protons across the membrane
Heal19_RS02590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Heal19_RS02595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Heal19_RS02600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Heal19_RS02605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Heal19_RS02610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Heal19_RS02615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Heal19_RS02620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Heal19_RS02625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Heal19_RS02635	COG1077	Cell shape determining protein MreB Mrl
Heal19_RS02640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Heal19_RS02650	COG0772	Belongs to the SEDS family
Heal19_RS02655	COG0509	glycine decarboxylation via glycine cleavage system
Heal19_RS02660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Heal19_RS02665	COG2011	ABC-type metal ion transport system permease component
Heal19_RS02670	COG1464	Belongs to the NlpA lipoprotein family
Heal19_RS02690	COG1181	Belongs to the D-alanine--D-alanine ligase family
Heal19_RS02710	COG0589	response to stress
Heal19_RS02725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Heal19_RS02730	COG2918	glutathione biosynthetic process
Heal19_RS02730	COG0189	ligase activity
Heal19_RS02735	COG1609	Transcriptional regulator
Heal19_RS02740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS02745	COG3715	PTS system
Heal19_RS02750	COG3716	PTS system mannose fructose sorbose family IID component
Heal19_RS02760	COG0366	Alpha amylase catalytic
Heal19_RS02765	COG0640	Transcriptional regulator
Heal19_RS02780	COG4493	Belongs to the UPF0637 family
Heal19_RS02785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Heal19_RS02790	COG1956	GAF domain-containing protein
Heal19_RS02795	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
Heal19_RS02800	COG1104	cysteine desulfurase activity
Heal19_RS02805	COG0301	tRNA thio-modification
Heal19_RS02810	COG1181	Belongs to the D-alanine--D-alanine ligase family
Heal19_RS02810	COG2918	glutathione biosynthetic process
Heal19_RS02820	COG0525	valine-tRNA ligase activity
Heal19_RS02825	COG0285	dihydrofolate synthase activity
Heal19_RS02830	COG2003	Belongs to the UPF0758 family
Heal19_RS02835	COG1077	Cell shape determining protein MreB Mrl
Heal19_RS02840	COG1792	Involved in formation and maintenance of cell shape
Heal19_RS02850	COG0850	regulation of cytokinetic process
Heal19_RS02855	COG2894	cell division
Heal19_RS02860	COG0765	amino acid transport
Heal19_RS02865	COG1126	abc transporter atp-binding protein
Heal19_RS02870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Heal19_RS02875	COG0527	aspartate kinase activity
Heal19_RS02880	COG0612	Peptidase, M16
Heal19_RS02885	COG0612	Peptidase, M16
Heal19_RS02890	COG1426	Protein conserved in bacteria
Heal19_RS02895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Heal19_RS02905	COG1058	Belongs to the CinA family
Heal19_RS02905	COG1546	Belongs to the CinA family
Heal19_RS02910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Heal19_RS02915	COG1418	mRNA catabolic process
Heal19_RS02920	COG1692	metallophosphoesterase
Heal19_RS02925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Heal19_RS02930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Heal19_RS02950	COG0632	four-way junction helicase activity
Heal19_RS02955	COG2255	four-way junction helicase activity
Heal19_RS02960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Heal19_RS02965	COG0343	queuine tRNA-ribosyltransferase activity
Heal19_RS02970	COG1862	Preprotein translocase
Heal19_RS02975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Heal19_RS02980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Heal19_RS02985	COG0513	Belongs to the DEAD box helicase family
Heal19_RS02990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Heal19_RS02995	COG4472	Bacterial protein of unknown function (DUF965)
Heal19_RS03000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Heal19_RS03005	COG3906	Belongs to the UPF0473 family
Heal19_RS03015	COG1193	negative regulation of DNA recombination
Heal19_RS03020	COG3118	belongs to the thioredoxin family
Heal19_RS03025	COG1719	4-vinyl reductase, 4VR
Heal19_RS03030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Heal19_RS03035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Heal19_RS03045	COG0517	IMP dehydrogenase activity
Heal19_RS03050	COG2171	N-acyltransferase activity
Heal19_RS03055	COG1473	amidohydrolase
Heal19_RS03060	COG0668	transmembrane transport
Heal19_RS03075	COG0789	Transcriptional regulator
Heal19_RS03080	COG0006	proline dipeptidase activity
Heal19_RS03085	COG1609	Transcriptional regulator
Heal19_RS03100	COG0217	transcriptional regulatory protein
Heal19_RS03110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Heal19_RS03140	COG0827	DNA restriction-modification system
Heal19_RS03145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Heal19_RS03150	COG1113	amino acid transport
Heal19_RS03160	COG0737	Belongs to the 5'-nucleotidase family
Heal19_RS03165	COG4470	Protein conserved in bacteria
Heal19_RS03170	COG0647	UMP catabolic process
Heal19_RS03180	COG0586	Pfam SNARE associated Golgi protein
Heal19_RS03190	COG1098	S1 RNA binding domain
Heal19_RS03330	COG1234	tRNA 3'-trailer cleavage
Heal19_RS03335	COG1393	Belongs to the ArsC family
Heal19_RS03340	COG4862	establishment of competence for transformation
Heal19_RS03350	COG1164	Oligoendopeptidase f
Heal19_RS03360	COG2357	RelA SpoT domain protein
Heal19_RS03365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Heal19_RS03370	COG0564	pseudouridine synthase activity
Heal19_RS03375	COG3142	Participates in the control of copper homeostasis
Heal19_RS03380	COG2706	6-phosphogluconolactonase activity
Heal19_RS03390	COG0628	permease
Heal19_RS03395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Heal19_RS03405	COG1114	Component of the transport system for branched-chain amino acids
Heal19_RS03415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Heal19_RS03420	COG1674	ftsk spoiiie
Heal19_RS03440	COG2001	Belongs to the MraZ family
Heal19_RS03445	COG0275	rRNA processing
Heal19_RS03460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Heal19_RS03465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Heal19_RS03470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Heal19_RS03475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Heal19_RS03490	COG1799	cell septum assembly
Heal19_RS03495	COG0762	integral membrane protein
Heal19_RS03505	COG3599	regulation of cell shape
Heal19_RS03510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Heal19_RS03515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Heal19_RS03520	COG0494	nUDIX hydrolase
Heal19_RS03530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Heal19_RS03535	COG1104	cysteine desulfurase activity
Heal19_RS03545	COG0482	sulfurtransferase activity
Heal19_RS03550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Heal19_RS03555	COG0569	domain protein
Heal19_RS03585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Heal19_RS03590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Heal19_RS03595	COG3584	3D domain protein
Heal19_RS03595	COG1388	LysM domain
Heal19_RS03605	COG1597	lipid kinase activity
Heal19_RS03610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Heal19_RS03625	COG0242	peptide deformylase activity
Heal19_RS03650	COG0039	L-malate dehydrogenase activity
Heal19_RS03655	COG4476	Belongs to the UPF0223 family
Heal19_RS03660	COG0483	inositol monophosphate 1-phosphatase activity
Heal19_RS03690	COG0772	Belongs to the SEDS family
Heal19_RS03695	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Heal19_RS03700	COG4471	UPF0298 protein
Heal19_RS03705	COG0742	ribosomal rna small subunit methyltransferase
Heal19_RS03710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Heal19_RS03715	COG3480	Lon protease (S16) C-terminal proteolytic domain
Heal19_RS03720	COG1555	photosystem II stabilization
Heal19_RS03720	COG1596	polysaccharide export
Heal19_RS03725	COG2131	deaminase
Heal19_RS03730	COG0658	competence protein
Heal19_RS03730	COG2333	competence protein COMEC
Heal19_RS03735	COG1466	dna polymerase III delta subunit
Heal19_RS03740	COG0268	Binds directly to 16S ribosomal RNA
Heal19_RS03745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Heal19_RS03770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Heal19_RS03775	COG0544	peptidyl-prolyl cis-trans isomerase activity
Heal19_RS03780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Heal19_RS03785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Heal19_RS03805	COG0765	amino acid transport
Heal19_RS03810	COG1126	abc transporter atp-binding protein
Heal19_RS03815	COG0322	excinuclease ABC activity
Heal19_RS03825	COG0489	protein tyrosine kinase activity
Heal19_RS03835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Heal19_RS03840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Heal19_RS03845	COG0297	glycogen (starch) synthase activity
Heal19_RS03870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Heal19_RS03875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Heal19_RS03875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Heal19_RS03875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Heal19_RS03880	COG1105	Belongs to the carbohydrate kinase PfkB family
Heal19_RS03885	COG1349	DNA-binding transcription factor activity
Heal19_RS03890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Heal19_RS03900	COG1234	tRNA 3'-trailer cleavage
Heal19_RS03905	COG0300	oxidoreductase activity
Heal19_RS03910	COG5416	Lipopolysaccharide assembly protein A domain
Heal19_RS03915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Heal19_RS03915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Heal19_RS03920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Heal19_RS03935	COG0393	Putative heavy-metal-binding
Heal19_RS03955	COG0772	Belongs to the SEDS family
Heal19_RS03965	COG1116	anion transmembrane transporter activity
Heal19_RS03970	COG1316	TRANSCRIPTIONal
Heal19_RS03980	COG0463	Glycosyl transferase, family 2
Heal19_RS03995	COG3425	synthase
Heal19_RS04010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Heal19_RS04015	COG4224	UPF0291 protein
Heal19_RS04020	COG3763	UPF0154 protein
Heal19_RS04025	COG0204	Acyl-transferase
Heal19_RS04030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Heal19_RS04035	COG2827	Endonuclease containing a URI domain
Heal19_RS04040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Heal19_RS04050	COG0052	Belongs to the universal ribosomal protein uS2 family
Heal19_RS04055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Heal19_RS04060	COG0528	UMP kinase activity
Heal19_RS04065	COG0233	cytoplasmic translational termination
Heal19_RS04070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Heal19_RS04075	COG4589	Belongs to the CDS family
Heal19_RS04080	COG0750	zinc metalloprotease
Heal19_RS04085	COG0442	prolyl-tRNA aminoacylation
Heal19_RS04090	COG2176	DNA-directed DNA polymerase activity
Heal19_RS04095	COG0779	Required for maturation of 30S ribosomal subunits
Heal19_RS04100	COG0195	Participates in both transcription termination and antitermination
Heal19_RS04105	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Heal19_RS04115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Heal19_RS04120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Heal19_RS04125	COG0738	Major facilitator superfamily
Heal19_RS04130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Heal19_RS04140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Heal19_RS04145	COG0287	Prephenate dehydrogenase
Heal19_RS04150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Heal19_RS04155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Heal19_RS04160	COG0196	riboflavin kinase activity
Heal19_RS04165	COG3527	Alpha-acetolactate decarboxylase
Heal19_RS04170	COG1420	regulation of RNA biosynthetic process
Heal19_RS04175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Heal19_RS04180	COG0443	Heat shock 70 kDa protein
Heal19_RS04185	COG0484	heat shock protein binding
Heal19_RS04195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Heal19_RS04205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Heal19_RS04210	COG1696	Membrane protein involved in D-alanine export
Heal19_RS04215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Heal19_RS04220	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
Heal19_RS04225	COG0481	GTPase activity
Heal19_RS04250	COG2094	Belongs to the DNA glycosylase MPG family
Heal19_RS04255	COG2264	protein methyltransferase activity
Heal19_RS04260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Heal19_RS04270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Heal19_RS04275	COG1490	D-aminoacyl-tRNA deacylase activity
Heal19_RS04280	COG0546	phosphoglycolate phosphatase activity
Heal19_RS04285	COG3001	Fructosamine kinase
Heal19_RS04290	COG4991	sh3 domain protein
Heal19_RS04290	COG3103	Sh3 type 3 domain protein
Heal19_RS04290	COG0860	N-Acetylmuramoyl-L-alanine amidase
Heal19_RS04295	COG0124	histidyl-tRNA synthetase
Heal19_RS04300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Heal19_RS04310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Heal19_RS04320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Heal19_RS04330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Heal19_RS04335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Heal19_RS04340	COG1610	YqeY-like protein
Heal19_RS04345	COG1702	phosphate starvation-inducible protein PhoH
Heal19_RS04350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Heal19_RS04355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Heal19_RS04360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Heal19_RS04365	COG1381	Involved in DNA repair and RecF pathway recombination
Heal19_RS04370	COG0752	glycyl-tRNA synthetase alpha subunit
Heal19_RS04375	COG0751	glycine-tRNA ligase activity
Heal19_RS04380	COG0358	DNA primase activity
Heal19_RS04385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Heal19_RS04390	COG1725	Transcriptional regulator
Heal19_RS04395	COG1131	(ABC) transporter
Heal19_RS04415	COG1131	(ABC) transporter
Heal19_RS04430	COG0519	Catalyzes the synthesis of GMP from XMP
Heal19_RS04440	COG1131	(ABC) transporter
Heal19_RS04450	COG4585	Histidine kinase
Heal19_RS04455	COG2197	response regulator
Heal19_RS04460	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS04465	COG0604	alcohol dehydrogenase
Heal19_RS04470	COG0583	DNA-binding transcription factor activity
Heal19_RS04500	COG0546	phosphoglycolate phosphatase activity
Heal19_RS04530	COG1349	DNA-binding transcription factor activity
Heal19_RS04535	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS04540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Heal19_RS04550	COG0477	Major facilitator Superfamily
Heal19_RS04555	COG0148	phosphopyruvate hydratase activity
Heal19_RS04560	COG2217	Heavy metal translocating P-type atpase
Heal19_RS04580	COG1846	Transcriptional regulator
Heal19_RS04590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Heal19_RS04590	COG0574	Belongs to the PEP-utilizing enzyme family
Heal19_RS04615	COG2384	SAM-dependent methyltransferase
Heal19_RS04620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Heal19_RS04630	COG0542	response to heat
Heal19_RS04640	COG0587	DNA-directed DNA polymerase activity
Heal19_RS04645	COG0205	6-phosphofructokinase activity
Heal19_RS04660	COG2996	Protein conserved in bacteria
Heal19_RS04665	COG4974	Belongs to the 'phage' integrase family
Heal19_RS04675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Heal19_RS04680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Heal19_RS04685	COG1187	pseudouridine synthase activity
Heal19_RS04690	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Heal19_RS04700	COG0514	ATP-dependent DNA helicase (RecQ)
Heal19_RS04710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Heal19_RS04715	COG0539	negative regulation of cytoplasmic translation
Heal19_RS04720	COG1160	GTP binding
Heal19_RS04730	COG0457	Tetratricopeptide repeat
Heal19_RS04735	COG0561	phosphatase activity
Heal19_RS04740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Heal19_RS04745	COG0617	tRNA 3'-terminal CCA addition
Heal19_RS04755	COG0488	(ABC) transporter
Heal19_RS04760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Heal19_RS04765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Heal19_RS04770	COG1307	EDD domain protein, DegV family
Heal19_RS04775	COG2755	lipolytic protein G-D-S-L family
Heal19_RS04780	COG4698	Protein conserved in bacteria
Heal19_RS04785	COG4479	Belongs to the UPF0346 family
Heal19_RS04790	COG3409	Peptidoglycan-binding domain 1 protein
Heal19_RS04790	COG0793	Belongs to the peptidase S41A family
Heal19_RS04795	COG2814	Major facilitator Superfamily
Heal19_RS04810	COG0583	DNA-binding transcription factor activity
Heal19_RS04815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Heal19_RS04820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Heal19_RS04825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Heal19_RS04830	COG0758	DNA mediated transformation
Heal19_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Heal19_RS04840	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Heal19_RS04845	COG4974	Belongs to the 'phage' integrase family
Heal19_RS04850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Heal19_RS04855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Heal19_RS04865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Heal19_RS04870	COG0187	DNA topoisomerase II activity
Heal19_RS04880	COG0583	DNA-binding transcription factor activity
Heal19_RS04885	COG1227	inorganic diphosphatase activity
Heal19_RS04890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Heal19_RS04930	COG1846	Transcriptional regulator
Heal19_RS04945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Heal19_RS04955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Heal19_RS04980	COG1113	amino acid transport
Heal19_RS05035	COG1307	EDD domain protein, DegV family
Heal19_RS05045	COG1293	RNA-binding protein homologous to eukaryotic snRNP
Heal19_RS05050	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Heal19_RS05055	COG1131	(ABC) transporter
Heal19_RS05080	COG5646	InterPro IPR014922
Heal19_RS05095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Heal19_RS05100	COG0505	Belongs to the CarA family
Heal19_RS05105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Heal19_RS05110	COG0564	pseudouridine synthase activity
Heal19_RS05115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Heal19_RS05120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Heal19_RS05135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Heal19_RS05165	COG1619	proteins homologs of microcin C7 resistance protein MccF
Heal19_RS05185	COG1216	Glycosyl transferase, family 2
Heal19_RS05195	COG1073	alpha beta
Heal19_RS05200	COG0477	Major facilitator Superfamily
Heal19_RS05210	COG0116	Belongs to the methyltransferase superfamily
Heal19_RS05220	COG3599	regulation of cell shape
Heal19_RS05225	COG4474	Belongs to the UPF0398 family
Heal19_RS05230	COG3331	DNA recombination
Heal19_RS05245	COG1840	ABC-type Fe3 transport system, periplasmic component
Heal19_RS05250	COG1177	transmembrane transport
Heal19_RS05260	COG1464	Belongs to the NlpA lipoprotein family
Heal19_RS05265	COG2011	ABC-type metal ion transport system permease component
Heal19_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Heal19_RS05280	COG0017	Asparaginyl-tRNA synthetase
Heal19_RS05295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Heal19_RS05295	COG1199	ATP-dependent helicase activity
Heal19_RS05315	COG1304	FMN binding
Heal19_RS05320	COG2017	converts alpha-aldose to the beta-anomer
Heal19_RS05340	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Heal19_RS05340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Heal19_RS05345	COG0561	phosphatase activity
Heal19_RS05350	COG0531	amino acid
Heal19_RS05385	COG1942	4-Oxalocrotonate Tautomerase
Heal19_RS05400	COG3237	CsbD-like
Heal19_RS05405	COG2261	transglycosylase associated protein
Heal19_RS05415	COG1597	lipid kinase activity
Heal19_RS05420	COG3152	Membrane
Heal19_RS05430	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Heal19_RS05445	COG3397	chitin binding
Heal19_RS05450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Heal19_RS05485	COG0477	Major facilitator Superfamily
Heal19_RS05495	COG1162	GTPase activity
Heal19_RS05500	COG1607	acyl-coa hydrolase
Heal19_RS05505	COG0583	DNA-binding transcription factor activity
Heal19_RS05510	COG1811	Na channel or pump
Heal19_RS05520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Heal19_RS05535	COG0439	Biotin carboxylase
Heal19_RS05550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Heal19_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS05560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Heal19_RS05565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Heal19_RS05570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Heal19_RS05575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Heal19_RS05585	COG0300	oxidoreductase activity
Heal19_RS05595	COG1063	alcohol dehydrogenase
Heal19_RS05600	COG1473	amidohydrolase
Heal19_RS05610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Heal19_RS05625	COG0159	tryptophan synthase activity
Heal19_RS05630	COG0133	tryptophan synthase activity
Heal19_RS05635	COG0135	phosphoribosylanthranilate isomerase activity
Heal19_RS05640	COG0134	indole-3-glycerol-phosphate synthase activity
Heal19_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Heal19_RS05650	COG0512	Glutamine amidotransferase of anthranilate synthase
Heal19_RS05650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Heal19_RS05685	COG0335	large ribosomal subunit rRNA binding
Heal19_RS05690	COG0336	Belongs to the RNA methyltransferase TrmD family
Heal19_RS05695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Heal19_RS05700	COG1837	Belongs to the UPF0109 family
Heal19_RS05705	COG0228	four-way junction DNA binding
Heal19_RS05710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Heal19_RS05715	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Heal19_RS05720	COG0552	protein localization to endoplasmic reticulum
Heal19_RS05725	COG1196	nuclear chromosome segregation
Heal19_RS05730	COG0571	ribonuclease III activity
Heal19_RS05735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Heal19_RS05740	COG0416	fatty acid biosynthetic process
Heal19_RS05745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Heal19_RS05750	COG1461	Dihydroxyacetone kinase
Heal19_RS05755	COG1302	Protein conserved in bacteria
Heal19_RS05760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Heal19_RS05765	COG1564	THIamine pyrophosphokinase
Heal19_RS05770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Heal19_RS05775	COG1162	GTPase activity
Heal19_RS05780	COG2815	serine threonine protein kinase
Heal19_RS05780	COG0515	serine threonine protein kinase
Heal19_RS05785	COG0631	protein serine/threonine phosphatase activity
Heal19_RS05790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Heal19_RS05790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Heal19_RS05795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Heal19_RS05800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Heal19_RS05805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Heal19_RS05810	COG1758	RNA polymerase activity
Heal19_RS05815	COG0194	GDP metabolic process
Heal19_RS05825	COG1174	glycine betaine transport
Heal19_RS05830	COG1732	Glycine betaine
Heal19_RS05845	COG0497	DNA recombination
Heal19_RS05850	COG1438	arginine binding
Heal19_RS05855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Heal19_RS05860	COG0142	geranyltranstransferase activity
Heal19_RS05865	COG1722	exodeoxyribonuclease VII activity
Heal19_RS05870	COG1570	exodeoxyribonuclease VII activity
Heal19_RS05875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Heal19_RS05880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Heal19_RS05885	COG1302	Protein conserved in bacteria
Heal19_RS05890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Heal19_RS05895	COG0006	proline dipeptidase activity
Heal19_RS05900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Heal19_RS05910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Heal19_RS05960	COG0789	Transcriptional regulator
Heal19_RS05965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Heal19_RS05970	COG0584	glycerophosphoryl diester phosphodiesterase
Heal19_RS05990	COG1940	carbohydrate kinase activity
Heal19_RS06000	COG0457	Tetratricopeptide repeat
Heal19_RS06000	COG0705	Rhomboid family
Heal19_RS06005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Heal19_RS06010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Heal19_RS06015	COG0768	penicillin binding
Heal19_RS06025	COG4841	protein insertion into membrane
Heal19_RS06040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Heal19_RS06045	COG0572	uridine kinase
Heal19_RS06050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Heal19_RS06055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Heal19_RS06055	COG0072	phenylalanine-tRNA ligase activity
Heal19_RS06060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Heal19_RS06065	COG1733	regulation of RNA biosynthetic process
Heal19_RS06075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Heal19_RS06080	COG1254	Belongs to the acylphosphatase family
Heal19_RS06085	COG0706	membrane insertase activity
Heal19_RS06100	COG0419	ATPase involved in DNA repair
Heal19_RS06110	COG5002	protein histidine kinase activity
Heal19_RS06115	COG0745	RESPONSE REGULATOR receiver
Heal19_RS06120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Heal19_RS06125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Heal19_RS06145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Heal19_RS06155	COG1323	Belongs to the UPF0348 family
Heal19_RS06160	COG2226	methyltransferase
Heal19_RS06165	COG0799	negative regulation of ribosome biogenesis
Heal19_RS06170	COG1713	HD superfamily hydrolase involved in NAD metabolism
Heal19_RS06175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Heal19_RS06180	COG1534	Rna-binding protein
Heal19_RS06200	COG1215	transferase activity, transferring glycosyl groups
Heal19_RS06210	COG1733	regulation of RNA biosynthetic process
Heal19_RS06215	COG0604	alcohol dehydrogenase
Heal19_RS06220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Heal19_RS06230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Heal19_RS06235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Heal19_RS06240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Heal19_RS06245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Heal19_RS06250	COG1484	DNA-dependent DNA replication
Heal19_RS06255	COG3611	Membrane attachment protein
Heal19_RS06260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Heal19_RS06265	COG0237	dephospho-CoA kinase activity
Heal19_RS06270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Heal19_RS06275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Heal19_RS06275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Heal19_RS06285	COG3655	Transcriptional regulator
Heal19_RS06305	COG2181	nitrate reductase activity
Heal19_RS06315	COG1140	nitrate reductase beta subunit
Heal19_RS06320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Heal19_RS06325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Heal19_RS06335	COG0303	'Molybdopterin
Heal19_RS06340	COG1763	Mo-molybdopterin cofactor biosynthetic process
Heal19_RS06345	COG0315	cyclic pyranopterin monophosphate synthase activity
Heal19_RS06370	COG2197	response regulator
Heal19_RS06395	COG2151	metal-sulfur cluster biosynthetic enzyme
Heal19_RS06400	COG2223	nitrite transmembrane transporter activity
Heal19_RS06405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Heal19_RS06420	COG0716	FMN binding
Heal19_RS06430	COG1120	ATPase activity
Heal19_RS06440	COG0719	Fe-S assembly protein
Heal19_RS06450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Heal19_RS06455	COG0719	Fe-S assembly protein
Heal19_RS06480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Heal19_RS06485	COG1674	ftsk spoiiie
Heal19_RS06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Heal19_RS06500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Heal19_RS06505	COG0510	thiamine kinase activity
Heal19_RS06510	COG4473	ABC transporter
Heal19_RS06515	COG1131	(ABC) transporter
Heal19_RS06520	COG0537	adenosine 5'-monophosphoramidase activity
Heal19_RS06530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Heal19_RS06560	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS06570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Heal19_RS06585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Heal19_RS06590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Heal19_RS06590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Heal19_RS06595	COG0307	riboflavin synthase, alpha
Heal19_RS06600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Heal19_RS06600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Heal19_RS06620	COG0463	Glycosyl transferase, family 2
Heal19_RS06625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Heal19_RS06635	COG0148	phosphopyruvate hydratase activity
Heal19_RS06680	COG1053	succinate dehydrogenase
Heal19_RS06680	COG3976	FMN-binding domain protein
Heal19_RS06680	COG0431	NADPH-dependent FMN reductase
Heal19_RS06690	COG0583	DNA-binding transcription factor activity
Heal19_RS06705	COG3481	metal-dependent phosphohydrolase, HD sub domain
Heal19_RS06710	COG4717	serine-type aminopeptidase activity
Heal19_RS06715	COG0420	3'-5' exonuclease activity
Heal19_RS06720	COG3679	Belongs to the UPF0342 family
Heal19_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Heal19_RS06730	COG1438	arginine binding
Heal19_RS06735	COG0436	Aminotransferase
Heal19_RS06745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Heal19_RS06750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Heal19_RS06755	COG1376	ErfK ybiS ycfS ynhG family protein
Heal19_RS06770	COG1136	(ABC) transporter
Heal19_RS06770	COG0577	efflux transmembrane transporter activity
Heal19_RS06780	COG0018	arginyl-trna synthetase
Heal19_RS06785	COG2153	protein acetylation
Heal19_RS06805	COG0534	Mate efflux family protein
Heal19_RS06810	COG3273	potassium ion transport
Heal19_RS06810	COG0471	metal ion transport
Heal19_RS06820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Heal19_RS06825	COG0529	Catalyzes the synthesis of activated sulfate
Heal19_RS06830	COG2046	Belongs to the sulfate adenylyltransferase family
Heal19_RS06840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Heal19_RS06845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Heal19_RS06845	COG0646	methionine synthase
Heal19_RS06960	COG0740	serine-type endopeptidase activity
Heal19_RS07120	COG1396	sequence-specific DNA binding
Heal19_RS07155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Heal19_RS07170	COG1846	Transcriptional regulator
Heal19_RS07190	COG3279	Response regulator of the LytR AlgR family
Heal19_RS07205	COG0561	phosphatase activity
Heal19_RS07210	COG0697	spore germination
Heal19_RS07220	COG0789	Transcriptional regulator
Heal19_RS07225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Heal19_RS07235	COG0789	Transcriptional regulator
Heal19_RS07245	COG0596	Alpha beta hydrolase
Heal19_RS07250	COG2378	regulation of single-species biofilm formation
Heal19_RS07275	COG1511	domain protein
Heal19_RS07275	COG1511	domain protein
Heal19_RS07280	COG1970	mechanosensitive ion channel activity
Heal19_RS07285	COG1428	Deoxynucleoside kinase
Heal19_RS07290	COG0584	glycerophosphoryl diester phosphodiesterase
Heal19_RS07300	COG0395	ABC-type sugar transport system, permease component
Heal19_RS07305	COG1175	transmembrane transport
Heal19_RS07310	COG3842	ATPase activity
Heal19_RS07320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Heal19_RS07325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Heal19_RS07330	COG1187	pseudouridine synthase activity
Heal19_RS07335	COG2244	polysaccharide biosynthetic process
Heal19_RS07340	COG0495	leucyl-tRNA aminoacylation
Heal19_RS07350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Heal19_RS07365	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07380	COG0477	Major facilitator Superfamily
Heal19_RS07385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Heal19_RS07395	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07400	COG2040	homocysteine
Heal19_RS07405	COG0833	amino acid
Heal19_RS07420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Heal19_RS07440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Heal19_RS07530	COG1368	sulfuric ester hydrolase activity
Heal19_RS07535	COG4703	Protein of unknown function (DUF1797)
Heal19_RS07540	COG0436	Aminotransferase
Heal19_RS07545	COG1686	Belongs to the peptidase S11 family
Heal19_RS07555	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07560	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07580	COG0542	response to heat
Heal19_RS07585	COG0582	viral genome integration into host DNA
Heal19_RS07595	COG4608	Belongs to the ABC transporter superfamily
Heal19_RS07600	COG0444	Belongs to the ABC transporter superfamily
Heal19_RS07605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Heal19_RS07610	COG0601	transmembrane transport
Heal19_RS07615	COG4166	transmembrane transport
Heal19_RS07650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Heal19_RS07655	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Heal19_RS07660	COG1070	Carbohydrate kinase
Heal19_RS07665	COG2610	gluconate transmembrane transporter activity
Heal19_RS07670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Heal19_RS07675	COG0628	permease
Heal19_RS07685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Heal19_RS07705	COG3557	Belongs to the UPF0374 family
Heal19_RS07710	COG2137	regulation of response to DNA damage stimulus
Heal19_RS07760	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07775	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07780	COG0438	transferase activity, transferring glycosyl groups
Heal19_RS07780	COG0297	glycogen (starch) synthase activity
Heal19_RS07785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Heal19_RS07795	COG4464	protein tyrosine phosphatase activity
Heal19_RS07800	COG0489	protein tyrosine kinase activity
Heal19_RS07810	COG0582	viral genome integration into host DNA
Heal19_RS07815	COG1088	dTDP-glucose 4,6-dehydratase activity
Heal19_RS07840	COG1216	Glycosyl transferase, family 2
Heal19_RS07880	COG0562	UDP-galactopyranose mutase
Heal19_RS07890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS07900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Heal19_RS07910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Heal19_RS07935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS07950	COG0513	Belongs to the DEAD box helicase family
Heal19_RS07955	COG0673	inositol 2-dehydrogenase activity
Heal19_RS07960	COG1278	Cold shock
Heal19_RS07975	COG1737	Transcriptional regulator
Heal19_RS07985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS08000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Heal19_RS08005	COG1597	lipid kinase activity
Heal19_RS08010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Heal19_RS08015	COG0154	amidase activity
Heal19_RS08020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Heal19_RS08025	COG4851	CamS sex pheromone cAM373 precursor
Heal19_RS08030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Heal19_RS08040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Heal19_RS08045	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Heal19_RS08050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Heal19_RS08055	COG1705	Flagellar rod assembly protein muramidase FlgJ
Heal19_RS08070	COG0142	geranyltranstransferase activity
Heal19_RS08085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Heal19_RS08090	COG4988	ABC transporter
Heal19_RS08095	COG1294	oxidase, subunit
Heal19_RS08100	COG1271	oxidase subunit
Heal19_RS08115	COG4684	Psort location CytoplasmicMembrane, score
Heal19_RS08120	COG0531	amino acid
Heal19_RS08130	COG0281	malic enzyme
Heal19_RS08135	COG0583	DNA-binding transcription factor activity
Heal19_RS08140	COG0583	DNA-binding transcription factor activity
Heal19_RS08155	COG0114	fumarate hydratase activity
Heal19_RS08170	COG2826	transposase and inactivated derivatives, IS30 family
Heal19_RS08185	COG3052	prosthetic group binding
Heal19_RS08205	COG0471	metal ion transport
Heal19_RS08210	COG0039	L-malate dehydrogenase activity
Heal19_RS08220	COG0803	Belongs to the bacterial solute-binding protein 9 family
Heal19_RS08225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Heal19_RS08230	COG1121	(ABC) transporter
Heal19_RS08235	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Heal19_RS08240	COG4977	sequence-specific DNA binding
Heal19_RS08240	COG1917	Cupin 2, conserved barrel domain protein
Heal19_RS08250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Heal19_RS08255	COG2151	metal-sulfur cluster biosynthetic enzyme
Heal19_RS08260	COG0471	metal ion transport
Heal19_RS08265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Heal19_RS08270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Heal19_RS08275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Heal19_RS08280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Heal19_RS08300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Heal19_RS08305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Heal19_RS08310	COG0101	tRNA pseudouridine synthase activity
Heal19_RS08320	COG1122	ATPase activity
Heal19_RS08325	COG1122	ATPase activity
Heal19_RS08335	COG4939	FMN-binding domain protein
Heal19_RS08360	COG0203	ribosomal protein L17
Heal19_RS08365	COG0202	RNA polymerase activity
Heal19_RS08370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Heal19_RS08375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Heal19_RS08380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Heal19_RS08385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Heal19_RS08390	COG0563	adenylate kinase activity
Heal19_RS08400	COG0200	Binds to the 23S rRNA
Heal19_RS08405	COG1841	ribosomal large subunit assembly
Heal19_RS08410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Heal19_RS08415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Heal19_RS08420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Heal19_RS08425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Heal19_RS08430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Heal19_RS08435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Heal19_RS08440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Heal19_RS08445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Heal19_RS08450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Heal19_RS08455	COG0255	Belongs to the universal ribosomal protein uL29 family
Heal19_RS08460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Heal19_RS08465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Heal19_RS08470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Heal19_RS08475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Heal19_RS08480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Heal19_RS08485	COG0089	rRNA binding
Heal19_RS08490	COG0088	Forms part of the polypeptide exit tunnel
Heal19_RS08495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Heal19_RS08500	COG0051	transcription antitermination factor activity, RNA binding
Heal19_RS08505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Heal19_RS08510	COG0049	tRNA binding
Heal19_RS08515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Heal19_RS08520	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Heal19_RS08525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Heal19_RS08530	COG0085	RNA polymerase activity
Heal19_RS08540	COG0542	response to heat
Heal19_RS08545	COG4463	regulation of RNA biosynthetic process
Heal19_RS08585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Heal19_RS08590	COG1428	Deoxynucleoside kinase
Heal19_RS08600	COG0833	amino acid
Heal19_RS08605	COG0028	Belongs to the TPP enzyme family
Heal19_RS08610	COG1959	2 iron, 2 sulfur cluster binding
Heal19_RS08630	COG1316	TRANSCRIPTIONal
Heal19_RS08640	COG2966	Psort location CytoplasmicMembrane, score
Heal19_RS08645	COG1278	Cold shock
Heal19_RS08665	COG2814	Major facilitator Superfamily
Heal19_RS08695	COG0367	asparagine synthase
Heal19_RS08700	COG0527	aspartate kinase activity
Heal19_RS08705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Heal19_RS08755	COG0640	Transcriptional regulator
Heal19_RS08760	COG0564	pseudouridine synthase activity
Heal19_RS08765	COG0514	ATP-dependent DNA helicase (RecQ)
Heal19_RS08785	COG4690	dipeptidase activity
Heal19_RS08790	COG2502	aspartate--ammonia ligase
Heal19_RS08800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Heal19_RS08810	COG1053	succinate dehydrogenase
Heal19_RS08815	COG0583	DNA-binding transcription factor activity
Heal19_RS08830	COG0572	uridine kinase
Heal19_RS08875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Heal19_RS08880	COG0308	aminopeptidase N
Heal19_RS08910	COG1302	Protein conserved in bacteria
Heal19_RS08925	COG2261	transglycosylase associated protein
Heal19_RS08930	COG2755	lipolytic protein G-D-S-L family
Heal19_RS08930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Heal19_RS08945	COG2814	Major facilitator Superfamily
Heal19_RS08950	COG1733	regulation of RNA biosynthetic process
Heal19_RS08955	COG1266	CAAX protease self-immunity
Heal19_RS08965	COG1396	sequence-specific DNA binding
Heal19_RS08975	COG0519	Catalyzes the synthesis of GMP from XMP
Heal19_RS08975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Heal19_RS08980	COG1072	(Pantothenic acid kinase))
Heal19_RS08985	COG2070	2-Nitropropane dioxygenase
Heal19_RS08995	COG3973	AAA domain
Heal19_RS09000	COG0586	Pfam SNARE associated Golgi protein
Heal19_RS09005	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS09010	COG2190	(PTS) system
Heal19_RS09010	COG1263	PTS System
Heal19_RS09010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS09015	COG3711	transcriptional antiterminator
Heal19_RS09020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Heal19_RS09020	COG0456	acetyltransferase
Heal19_RS09025	COG0569	domain protein
Heal19_RS09025	COG0475	glutathione-regulated potassium exporter activity
Heal19_RS09030	COG0588	phosphoglycerate mutase activity
Heal19_RS09045	COG2076	Multidrug Resistance protein
Heal19_RS09055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Heal19_RS09085	COG1846	Transcriptional regulator
Heal19_RS09090	COG0531	amino acid
Heal19_RS09095	COG3394	polysaccharide catabolic process
Heal19_RS09100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS09100	COG1263	PTS System
Heal19_RS09110	COG1263	PTS System
Heal19_RS09110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS09110	COG2190	(PTS) system
Heal19_RS09115	COG0765	amino acid transport
Heal19_RS09120	COG0765	amino acid transport
Heal19_RS09125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Heal19_RS09140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Heal19_RS09145	COG0436	Aminotransferase
Heal19_RS09150	COG0546	phosphoglycolate phosphatase activity
Heal19_RS09165	COG0735	belongs to the Fur family
Heal19_RS09170	COG0194	GDP metabolic process
Heal19_RS09195	COG0531	amino acid
Heal19_RS09210	COG2936	dipeptidyl-peptidase activity
Heal19_RS09215	COG2755	lipolytic protein G-D-S-L family
Heal19_RS09215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Heal19_RS09225	COG2267	carboxylic ester hydrolase activity
Heal19_RS09230	COG0028	Belongs to the TPP enzyme family
Heal19_RS09235	COG0196	riboflavin kinase activity
Heal19_RS09240	COG0028	Belongs to the TPP enzyme family
Heal19_RS09245	COG2252	PERMEase
Heal19_RS09260	COG3475	LICD family
Heal19_RS09270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Heal19_RS09275	COG0248	Ppx GppA phosphatase
Heal19_RS09275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Heal19_RS09280	COG0477	Major facilitator Superfamily
Heal19_RS09295	COG1393	Belongs to the ArsC family
Heal19_RS09310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Heal19_RS09325	COG0778	Nitroreductase
Heal19_RS09340	COG2017	converts alpha-aldose to the beta-anomer
Heal19_RS09350	COG0561	phosphatase activity
Heal19_RS09360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Heal19_RS09365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Heal19_RS09390	COG0025	NhaP-type Na H and K H
Heal19_RS09395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Heal19_RS09405	COG0708	Exodeoxyribonuclease III
Heal19_RS09420	COG0802	atpase or kinase
Heal19_RS09425	COG0280	phosphate acetyltransferase
Heal19_RS09430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Heal19_RS09435	COG0561	phosphatase activity
Heal19_RS09445	COG1126	abc transporter atp-binding protein
Heal19_RS09450	COG0765	amino acid transport
Heal19_RS09460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Heal19_RS09465	COG0557	exoribonuclease II activity
Heal19_RS09475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Heal19_RS09480	COG0038	chloride channel
Heal19_RS09490	COG0148	phosphopyruvate hydratase activity
Heal19_RS09495	COG0149	triose-phosphate isomerase activity
Heal19_RS09500	COG0126	phosphoglycerate kinase activity
Heal19_RS09510	COG2390	Transcriptional regulator
Heal19_RS09515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Heal19_RS09525	COG0740	serine-type endopeptidase activity
Heal19_RS09530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Heal19_RS09540	COG1481	regulation of sporulation
Heal19_RS09550	COG1660	Displays ATPase and GTPase activities
Heal19_RS09560	COG0165	Argininosuccinate lyase
Heal19_RS09565	COG0137	argininosuccinate synthase activity
Heal19_RS09570	COG1854	S-ribosylhomocysteine lyase activity
Heal19_RS09575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Heal19_RS09580	COG0556	nucleotide-excision repair
Heal19_RS09590	COG2814	Major facilitator Superfamily
Heal19_RS09600	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS09610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Heal19_RS09620	COG2323	membrane
Heal19_RS09625	COG0492	ferredoxin-NADP+ reductase activity
Heal19_RS09630	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS09640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Heal19_RS09645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Heal19_RS09650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Heal19_RS09655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Heal19_RS09660	COG1950	PFAM Membrane protein of
Heal19_RS09670	COG0704	Plays a role in the regulation of phosphate uptake
Heal19_RS09675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Heal19_RS09680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Heal19_RS09685	COG0581	inorganic phosphate transmembrane transporter activity
Heal19_RS09695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Heal19_RS09700	COG5002	protein histidine kinase activity
Heal19_RS09705	COG0745	RESPONSE REGULATOR receiver
Heal19_RS09720	COG0653	protein targeting
Heal19_RS09735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Heal19_RS09740	COG1739	Uncharacterized protein family UPF0029
Heal19_RS09745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Heal19_RS09750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Heal19_RS09755	COG0531	amino acid
Heal19_RS09760	COG0459	protein refolding
Heal19_RS09765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Heal19_RS09775	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Heal19_RS09780	COG0488	(ABC) transporter
Heal19_RS09785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Heal19_RS09790	COG0456	acetyltransferase
Heal19_RS09795	COG0456	acetyltransferase
Heal19_RS09800	COG1214	PFAM Peptidase M22, glycoprotease
Heal19_RS09810	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Heal19_RS09820	COG3639	organic phosphonate transmembrane transporter activity
Heal19_RS09825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Heal19_RS09830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Heal19_RS09835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Heal19_RS09850	COG4467	Involved in initiation control of chromosome replication
Heal19_RS09855	COG0470	DNA polymerase III
Heal19_RS09860	COG3870	Protein conserved in bacteria
Heal19_RS09865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Heal19_RS09875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Heal19_RS09880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Heal19_RS09885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Heal19_RS09900	COG2813	Specifically methylates the guanine in position
Heal19_RS09905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Heal19_RS09910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Heal19_RS09920	COG1611	Belongs to the LOG family
Heal19_RS09940	COG0222	ribosome binding
Heal19_RS09945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Heal19_RS09950	COG0081	regulation of translation
Heal19_RS09955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Heal19_RS09965	COG0250	Participates in transcription elongation, termination and antitermination
Heal19_RS09975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Heal19_RS09990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Heal19_RS09995	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Heal19_RS10000	COG0215	cysteine-tRNA ligase activity
Heal19_RS10005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Heal19_RS10010	COG4956	integral membrane protein (PIN domain superfamily)
Heal19_RS10020	COG0756	dUTP diphosphatase activity
Heal19_RS10030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Heal19_RS10045	COG0588	phosphoglycerate mutase activity
Heal19_RS10050	COG0697	spore germination
Heal19_RS10060	COG1316	TRANSCRIPTIONal
Heal19_RS10065	COG0825	malonyl-CoA metabolic process
Heal19_RS10075	COG0439	Biotin carboxylase
Heal19_RS10085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Heal19_RS10090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS10090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Heal19_RS10095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS10095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Heal19_RS10100	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Heal19_RS10100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Heal19_RS10110	COG3716	PTS system mannose fructose sorbose family IID component
Heal19_RS10115	COG3715	PTS system
Heal19_RS10135	COG0083	homoserine kinase activity
Heal19_RS10140	COG0460	homoserine dehydrogenase
Heal19_RS10145	COG3091	SprT-like family
Heal19_RS10150	COG2183	response to ionizing radiation
Heal19_RS10165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Heal19_RS10170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Heal19_RS10180	COG2188	Transcriptional regulator
Heal19_RS10190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Heal19_RS10240	COG3104	oligopeptide transport
Heal19_RS10285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Heal19_RS10290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Heal19_RS10295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Heal19_RS10310	COG0037	tRNA processing
Heal19_RS10315	COG1098	S1 RNA binding domain
Heal19_RS10325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Heal19_RS10330	COG2244	polysaccharide biosynthetic process
Heal19_RS10335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Heal19_RS10340	COG0193	aminoacyl-tRNA hydrolase activity
Heal19_RS10345	COG0039	L-malate dehydrogenase activity
Heal19_RS10365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Heal19_RS10370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Heal19_RS10375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Heal19_RS10380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Heal19_RS10385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Heal19_RS10390	COG0505	Belongs to the CarA family
Heal19_RS10395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Heal19_RS10400	COG3158	transport of potassium into the cell
Heal19_RS10405	COG2337	Toxic component of a toxin-antitoxin (TA) module
Heal19_RS10410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Heal19_RS10415	COG0736	holo-[acyl-carrier-protein] synthase activity
Heal19_RS10425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Heal19_RS10435	COG0501	Belongs to the peptidase M48B family
Heal19_RS10440	COG1704	LemA family
Heal19_RS10445	COG3764	Sortase (surface protein transpeptidase)
Heal19_RS10455	COG0254	rRNA binding
Heal19_RS10460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Heal19_RS10465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Heal19_RS10480	COG1760	l-serine dehydratase
Heal19_RS10485	COG1760	l-serine dehydratase
Heal19_RS10490	COG0814	amino acid
Heal19_RS10495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Heal19_RS10500	COG0504	CTP synthase activity
Heal19_RS10505	COG3343	RNA polymerase activity
Heal19_RS10515	COG0095	Lipoate-protein ligase
Heal19_RS10520	COG1078	dGTPase activity
Heal19_RS10540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Heal19_RS10550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Heal19_RS10555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Heal19_RS10560	COG1321	iron dependent repressor
Heal19_RS10560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Heal19_RS10565	COG1121	(ABC) transporter
Heal19_RS10570	COG1073	alpha beta
Heal19_RS10575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Heal19_RS10580	COG4466	Protein conserved in bacteria
Heal19_RS10585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Heal19_RS10590	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Heal19_RS10595	COG0084	hydrolase, TatD family'
Heal19_RS10600	COG2814	Major facilitator Superfamily
Heal19_RS10605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Heal19_RS10605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Heal19_RS10615	COG1801	Protein of unknown function DUF72
Heal19_RS10620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Heal19_RS10635	COG0248	Ppx GppA phosphatase
Heal19_RS10650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Heal19_RS10660	COG1940	carbohydrate kinase activity
Heal19_RS10665	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS10670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS10685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS10690	COG2188	Transcriptional regulator
Heal19_RS10695	COG0180	Tryptophanyl-tRNA synthetase
Heal19_RS10700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Heal19_RS10705	COG3973	AAA domain
Heal19_RS10740	COG2274	protein secretion by the type I secretion system
Heal19_RS10765	COG3279	Response regulator of the LytR AlgR family
Heal19_RS10785	COG0463	Glycosyl transferase, family 2
Heal19_RS10825	COG1114	Component of the transport system for branched-chain amino acids
Heal19_RS10830	COG0561	phosphatase activity
Heal19_RS10840	COG0561	phosphatase activity
Heal19_RS10850	COG0110	maltose O-acetyltransferase activity
Heal19_RS10885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS10895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Heal19_RS10905	COG1125	glycine betaine transport
Heal19_RS10925	COG0300	oxidoreductase activity
Heal19_RS10955	COG1881	PFAM PEBP family protein
Heal19_RS10960	COG3759	membrane
Heal19_RS10970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Heal19_RS10990	COG0004	ammonium transporteR
Heal19_RS10995	COG2814	Major facilitator Superfamily
Heal19_RS11010	COG1134	teichoic acid transport
Heal19_RS11015	COG1682	transport, permease protein
Heal19_RS11025	COG0436	Aminotransferase
Heal19_RS11030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Heal19_RS11035	COG2011	ABC-type metal ion transport system permease component
Heal19_RS11055	COG1268	BioY protein
Heal19_RS11090	COG1454	alcohol dehydrogenase
Heal19_RS11090	COG1012	belongs to the aldehyde dehydrogenase family
Heal19_RS11100	COG1131	(ABC) transporter
Heal19_RS11105	COG1725	Transcriptional regulator
Heal19_RS11135	COG3842	ATPase activity
Heal19_RS11175	COG1252	NADH dehydrogenase
Heal19_RS11180	COG1846	Transcriptional regulator
Heal19_RS11190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Heal19_RS11220	COG1388	LysM domain
Heal19_RS11220	COG3942	CHAP domain
Heal19_RS11225	COG0741	lytic transglycosylase activity
Heal19_RS11240	COG1136	(ABC) transporter
Heal19_RS11245	COG0577	efflux transmembrane transporter activity
Heal19_RS11255	COG2818	Glycosylase
Heal19_RS11260	COG1033	growth of symbiont in host cell
Heal19_RS11260	COG2409	Drug exporters of the RND superfamily
Heal19_RS11260	COG1033	growth of symbiont in host cell
Heal19_RS11260	COG2409	Drug exporters of the RND superfamily
Heal19_RS11270	COG2357	RelA SpoT domain protein
Heal19_RS11280	COG0277	FAD linked oxidase domain protein
Heal19_RS11285	COG1316	TRANSCRIPTIONal
Heal19_RS11305	COG1737	Transcriptional regulator
Heal19_RS11315	COG0745	RESPONSE REGULATOR receiver
Heal19_RS11320	COG5002	protein histidine kinase activity
Heal19_RS11330	COG2814	Major facilitator Superfamily
Heal19_RS11350	COG1914	H( )-stimulated, divalent metal cation uptake system
Heal19_RS11355	COG1309	transcriptional regulator
Heal19_RS11360	COG1959	2 iron, 2 sulfur cluster binding
Heal19_RS11370	COG0163	prenyltransferase activity
Heal19_RS11375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Heal19_RS11375	COG0463	Glycosyl transferase, family 2
Heal19_RS11380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Heal19_RS11385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Heal19_RS11390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Heal19_RS11400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS11400	COG2190	(PTS) system
Heal19_RS11400	COG1263	PTS System
Heal19_RS11405	COG1263	PTS System
Heal19_RS11405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS11405	COG2190	(PTS) system
Heal19_RS11410	COG0366	Alpha amylase catalytic
Heal19_RS11415	COG2188	Transcriptional regulator
Heal19_RS11440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Heal19_RS11445	COG0626	cystathionine gamma-synthase activity
Heal19_RS11450	COG1045	serine acetyltransferase
Heal19_RS11470	COG3964	amidohydrolase
Heal19_RS11485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS11490	COG2188	Transcriptional regulator
Heal19_RS11495	COG0431	NADPH-dependent FMN reductase
Heal19_RS11525	COG3118	belongs to the thioredoxin family
Heal19_RS11535	COG0246	Mannitol dehydrogenase
Heal19_RS11540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Heal19_RS11550	COG2213	PTS system mannitol-specific
Heal19_RS11560	COG0363	glucosamine-6-phosphate deaminase activity
Heal19_RS11575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Heal19_RS11585	COG0386	Belongs to the glutathione peroxidase family
Heal19_RS11595	COG4172	Belongs to the ABC transporter superfamily
Heal19_RS11610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Heal19_RS11615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Heal19_RS11645	COG0667	Aldo Keto reductase
Heal19_RS11650	COG0406	alpha-ribazole phosphatase activity
Heal19_RS11655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Heal19_RS11660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Heal19_RS11670	COG4166	transmembrane transport
Heal19_RS11675	COG4166	transmembrane transport
Heal19_RS11750	COG3842	ATPase activity
Heal19_RS11755	COG0366	Alpha amylase catalytic
Heal19_RS11765	COG3833	ABC-type maltose transport systems, permease component
Heal19_RS11770	COG1175	transmembrane transport
Heal19_RS11775	COG2182	Extracellular solute-binding protein
Heal19_RS11780	COG0366	Alpha amylase catalytic
Heal19_RS11785	COG1609	Transcriptional regulator
Heal19_RS11790	COG1609	Transcriptional regulator
Heal19_RS11795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS11800	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Heal19_RS11805	COG1461	Dihydroxyacetone kinase
Heal19_RS11810	COG2376	Dihydroxyacetone kinase
Heal19_RS11815	COG2376	Dihydroxyacetone kinase
Heal19_RS11820	COG1309	transcriptional regulator
Heal19_RS11825	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Heal19_RS11830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Heal19_RS11845	COG1131	(ABC) transporter
Heal19_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS11875	COG2188	Transcriptional regulator
Heal19_RS11885	COG4720	Psort location CytoplasmicMembrane, score
Heal19_RS11890	COG1122	ATPase activity
Heal19_RS11895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Heal19_RS11925	COG0667	Aldo Keto reductase
Heal19_RS11930	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS11935	COG2807	transmembrane transport
Heal19_RS11975	COG1983	PspC domain protein
Heal19_RS11985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Heal19_RS12000	COG1518	maintenance of DNA repeat elements
Heal19_RS12005	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
Heal19_RS12010	COG2267	carboxylic ester hydrolase activity
Heal19_RS12020	COG1113	amino acid transport
Heal19_RS12035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Heal19_RS12045	COG0352	thiamine-phosphate diphosphorylase activity
Heal19_RS12050	COG0351	phosphomethylpyrimidine kinase
Heal19_RS12055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Heal19_RS12065	COG1606	tRNA processing
Heal19_RS12070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS12075	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Heal19_RS12080	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Heal19_RS12085	COG1691	(AIR) carboxylase
Heal19_RS12090	COG3875	lactate racemase activity
Heal19_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Heal19_RS12100	COG0310	cobalt ion transport
Heal19_RS12105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Heal19_RS12110	COG1122	ATPase activity
Heal19_RS12135	COG4166	transmembrane transport
Heal19_RS12145	COG3022	response to hydroperoxide
Heal19_RS12150	COG2267	carboxylic ester hydrolase activity
Heal19_RS12170	COG0604	alcohol dehydrogenase
Heal19_RS12205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Heal19_RS12225	COG2368	4-hydroxyphenylacetate
Heal19_RS12230	COG2365	Tyrosine phosphatase family
Heal19_RS12240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
Heal19_RS12245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Heal19_RS12250	COG2508	Transcriptional regulator
Heal19_RS12255	COG0778	Nitroreductase
Heal19_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS12270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Heal19_RS12285	COG0471	metal ion transport
Heal19_RS12290	COG3976	FMN-binding domain protein
Heal19_RS12290	COG1053	succinate dehydrogenase
Heal19_RS12290	COG0431	NADPH-dependent FMN reductase
Heal19_RS12315	COG1573	uracil-dna glycosylase
Heal19_RS12320	COG3586	endonuclease activity
Heal19_RS12325	COG1012	belongs to the aldehyde dehydrogenase family
Heal19_RS12335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Heal19_RS12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Heal19_RS12345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Heal19_RS12350	COG4853	Protein conserved in bacteria
Heal19_RS12360	COG5002	protein histidine kinase activity
Heal19_RS12365	COG0745	RESPONSE REGULATOR receiver
Heal19_RS12380	COG1278	Cold shock
Heal19_RS12390	COG1554	hydrolase, family 65, central catalytic
Heal19_RS12395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Heal19_RS12405	COG0366	Alpha amylase catalytic
Heal19_RS12405	COG3103	Sh3 type 3 domain protein
Heal19_RS12410	COG0058	SHG alpha-glucan phosphorylase activity
Heal19_RS12415	COG0297	glycogen (starch) synthase activity
Heal19_RS12420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Heal19_RS12425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Heal19_RS12430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Heal19_RS12435	COG4166	transmembrane transport
Heal19_RS12440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Heal19_RS12445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Heal19_RS12450	COG2814	Major facilitator Superfamily
Heal19_RS12460	COG0305	Participates in initiation and elongation during chromosome replication
Heal19_RS12465	COG0359	binds to the 23S rRNA
Heal19_RS12475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Heal19_RS12480	COG0629	single-stranded DNA binding
Heal19_RS12485	COG0360	Binds together with S18 to 16S ribosomal RNA
Heal19_RS12495	COG0187	DNA topoisomerase II activity
Heal19_RS12500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Heal19_RS12505	COG2501	S4 domain
Heal19_RS12510	COG0592	DNA-directed DNA polymerase activity
Heal19_RS12515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Heal19_RS12520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Heal19_RS12525	COG0594	ribonuclease P activity
Heal19_RS12530	COG0706	membrane insertase activity
Heal19_RS12535	COG4166	transmembrane transport
Heal19_RS12545	COG1847	R3H domain protein
Heal19_RS12550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Heal19_RS12555	COG0445	tRNA wobble uridine modification
Heal19_RS12595	COG1307	EDD domain protein, DegV family
Heal19_RS12610	COG3479	Phenolic acid decarboxylase
Heal19_RS12615	COG1695	Transcriptional regulator
Heal19_RS12625	COG1012	belongs to the aldehyde dehydrogenase family
Heal19_RS12625	COG1454	alcohol dehydrogenase
Heal19_RS12630	COG1609	Transcriptional regulator
Heal19_RS12640	COG1869	D-ribose catabolic process
Heal19_RS12645	COG4975	Glucose uptake
Heal19_RS12665	COG3730	PTS system glucitol sorbitol-specific
Heal19_RS12670	COG3732	PTS system glucitol sorbitol-specific
Heal19_RS12685	COG2188	Transcriptional regulator
Heal19_RS12690	COG1132	(ABC) transporter
Heal19_RS12695	COG1132	(ABC) transporter
Heal19_RS12700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Heal19_RS12700	COG2207	Transcriptional regulator
Heal19_RS12715	COG0395	ABC-type sugar transport system, permease component
Heal19_RS12725	COG0366	Alpha amylase catalytic
Heal19_RS12735	COG2972	Histidine kinase
Heal19_RS12740	COG4753	response regulator
Heal19_RS12740	COG2207	Transcriptional regulator
Heal19_RS12750	COG3842	ATPase activity
Heal19_RS12760	COG2188	Transcriptional regulator
Heal19_RS12770	COG0383	alpha-mannosidase activity
Heal19_RS12775	COG1940	carbohydrate kinase activity
Heal19_RS12780	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS12790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Heal19_RS12790	COG3711	transcriptional antiterminator
Heal19_RS12800	COG3730	PTS system glucitol sorbitol-specific
Heal19_RS12805	COG3732	PTS system glucitol sorbitol-specific
Heal19_RS12820	COG1957	nucleoside hydrolase
Heal19_RS12825	COG0604	alcohol dehydrogenase
Heal19_RS12830	COG4702	Belongs to the UPF0303 family
Heal19_RS12835	COG0673	inositol 2-dehydrogenase activity
Heal19_RS12840	COG2814	Major facilitator Superfamily
Heal19_RS12845	COG0673	inositol 2-dehydrogenase activity
Heal19_RS12850	COG1082	Xylose isomerase domain protein TIM barrel
Heal19_RS12855	COG0673	inositol 2-dehydrogenase activity
Heal19_RS12860	COG0673	inositol 2-dehydrogenase activity
Heal19_RS12865	COG2814	Major facilitator Superfamily
Heal19_RS12875	COG3775	system Galactitol-specific IIC component
Heal19_RS12890	COG1349	DNA-binding transcription factor activity
Heal19_RS12895	COG2207	Transcriptional regulator
Heal19_RS12900	COG2814	Major facilitator Superfamily
Heal19_RS12905	COG1070	Carbohydrate kinase
Heal19_RS12910	COG3254	rhamnose metabolic process
Heal19_RS12915	COG4806	L-rhamnose isomerase
Heal19_RS12920	COG0235	Class ii aldolase
Heal19_RS12935	COG0028	Belongs to the TPP enzyme family
Heal19_RS12940	COG1959	2 iron, 2 sulfur cluster binding
Heal19_RS12945	COG0028	Belongs to the TPP enzyme family
Heal19_RS12965	COG4512	PFAM Accessory gene regulator B
Heal19_RS12985	COG1393	Belongs to the ArsC family
Heal19_RS12995	COG2261	transglycosylase associated protein
Heal19_RS13015	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Heal19_RS13020	COG1609	Transcriptional regulator
Heal19_RS13040	COG2160	L-arabinose isomerase activity
Heal19_RS13045	COG0110	maltose O-acetyltransferase activity
Heal19_RS13055	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Heal19_RS13060	COG1349	DNA-binding transcription factor activity
Heal19_RS13070	COG3414	Phosphotransferase system galactitol-specific IIB component
Heal19_RS13075	COG3775	system Galactitol-specific IIC component
Heal19_RS13110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Heal19_RS13125	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
Heal19_RS13140	COG2211	Major facilitator Superfamily
Heal19_RS13160	COG2190	(PTS) system
Heal19_RS13160	COG1263	PTS System
Heal19_RS13160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS13165	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS13170	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS13175	COG3711	transcriptional antiterminator
Heal19_RS13185	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS13195	COG2971	BadF BadG BcrA BcrD
Heal19_RS13200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Heal19_RS13205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS13210	COG2188	Transcriptional regulator
Heal19_RS13215	COG2267	carboxylic ester hydrolase activity
Heal19_RS13225	COG2271	Major facilitator Superfamily
Heal19_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS13260	COG0583	DNA-binding transcription factor activity
Heal19_RS13265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Heal19_RS13270	COG0710	3-dehydroquinate dehydratase activity
Heal19_RS13290	COG0667	Aldo Keto reductase
Heal19_RS13295	COG1609	Transcriptional regulator
Heal19_RS13300	COG2017	converts alpha-aldose to the beta-anomer
Heal19_RS13305	COG2190	(PTS) system
Heal19_RS13305	COG2211	Major facilitator Superfamily
Heal19_RS13325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Heal19_RS13330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Heal19_RS13335	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Heal19_RS13340	COG1609	Transcriptional regulator
Heal19_RS13345	COG2944	sequence-specific DNA binding
Heal19_RS13350	COG2184	nucleotidyltransferase activity
Heal19_RS13370	COG0477	Major facilitator Superfamily
Heal19_RS13380	COG1609	Transcriptional regulator
Heal19_RS13385	COG1874	Beta-galactosidase
Heal19_RS13395	COG1114	Component of the transport system for branched-chain amino acids
Heal19_RS13405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS13450	COG0446	pyridine nucleotide-disulphide oxidoreductase
Heal19_RS13465	COG3590	peptidase
Heal19_RS13470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Heal19_RS13490	COG1937	Protein conserved in bacteria
Heal19_RS13495	COG3118	belongs to the thioredoxin family
Heal19_RS13500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Heal19_RS13505	COG2217	Heavy metal translocating P-type atpase
Heal19_RS13520	COG2226	methyltransferase
Heal19_RS13530	COG1309	transcriptional regulator
Heal19_RS13565	COG1388	LysM domain
Heal19_RS13565	COG0791	NLP P60 protein
Heal19_RS13570	COG0076	glutamate decarboxylase activity
Heal19_RS13595	COG2207	Transcriptional regulator
Heal19_RS13630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Heal19_RS13635	COG1968	undecaprenyl-diphosphatase activity
Heal19_RS13655	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS13665	COG0737	Belongs to the 5'-nucleotidase family
Heal19_RS13720	COG0477	Major facilitator Superfamily
Heal19_RS13745	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
Heal19_RS13760	COG0697	spore germination
Heal19_RS13790	COG0071	Belongs to the small heat shock protein (HSP20) family
Heal19_RS13805	COG1194	a g-specific adenine glycosylase
Heal19_RS13815	COG3189	MarR family transcriptional regulator
Heal19_RS13820	COG1393	Belongs to the ArsC family
Heal19_RS13835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Heal19_RS13845	COG1113	amino acid transport
Heal19_RS13860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Heal19_RS13865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Heal19_RS13875	COG2315	Protein conserved in bacteria
Heal19_RS13885	COG2217	Heavy metal translocating P-type atpase
Heal19_RS13915	COG4989	oxidoreductase activity
Heal19_RS13920	COG2151	metal-sulfur cluster biosynthetic enzyme
Heal19_RS13925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Heal19_RS13930	COG1882	Formate acetyltransferase
Heal19_RS13935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Heal19_RS13965	COG2814	Major facilitator Superfamily
Heal19_RS13970	COG0803	Belongs to the bacterial solute-binding protein 9 family
Heal19_RS13985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Heal19_RS13990	COG0302	gtp cyclohydrolase
Heal19_RS14000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Heal19_RS14035	COG0640	Transcriptional regulator
Heal19_RS14040	COG1272	protein, Hemolysin III
Heal19_RS14055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Heal19_RS14060	COG0628	permease
Heal19_RS14065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Heal19_RS14070	COG3158	transport of potassium into the cell
Heal19_RS14075	COG0531	amino acid
Heal19_RS14090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Heal19_RS14095	COG2365	Tyrosine phosphatase family
Heal19_RS14100	COG0516	GMP reductase activity
Heal19_RS14105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Heal19_RS14110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Heal19_RS14125	COG1929	Belongs to the glycerate kinase type-1 family
Heal19_RS14135	COG1562	ergosterol biosynthetic process
Heal19_RS14140	COG1233	COG1233 Phytoene dehydrogenase and related
Heal19_RS14430	COG2738	Putative neutral zinc metallopeptidase
Heal19_RS14440	COG1307	EDD domain protein, DegV family
Heal19_RS14450	COG1380	Effector of murein hydrolase LrgA
Heal19_RS14475	COG0735	belongs to the Fur family
Heal19_RS14505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS14505	COG1263	PTS System
Heal19_RS14505	COG2190	(PTS) system
Heal19_RS14520	COG0561	phosphatase activity
Heal19_RS14535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Heal19_RS14540	COG4619	ABC transporter
Heal19_RS14545	COG0390	transport system, permease component
Heal19_RS14555	COG1609	Transcriptional regulator
Heal19_RS14560	COG0366	Alpha amylase catalytic
Heal19_RS14565	COG2190	(PTS) system
Heal19_RS14565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS14565	COG1263	PTS System
Heal19_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Heal19_RS14595	COG1126	abc transporter atp-binding protein
Heal19_RS14600	COG0765	amino acid transport
Heal19_RS14605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Heal19_RS14610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Heal19_RS14615	COG0583	DNA-binding transcription factor activity
Heal19_RS14625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Heal19_RS14630	COG0357	Ribosomal RNA small subunit methyltransferase G
Heal19_RS14640	COG1192	Involved in chromosome partitioning
Heal19_RS14645	COG1475	DNA binding
Heal19_RS14650	COG4481	Protein conserved in bacteria
Heal19_RS14655	COG0012	GTP binding
Heal19_RS14665	COG0517	IMP dehydrogenase activity
Heal19_RS14665	COG0516	GMP reductase activity
Heal19_RS14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Heal19_RS14690	COG1686	Belongs to the peptidase S11 family
Heal19_RS14695	COG1247	-acetyltransferase
Heal19_RS14730	COG0515	serine threonine protein kinase
Heal19_RS14730	COG2815	serine threonine protein kinase
Heal19_RS14740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Heal19_RS14750	COG1940	carbohydrate kinase activity
Heal19_RS14750	COG1846	Transcriptional regulator
Heal19_RS14755	COG0628	permease
Heal19_RS14760	COG0588	phosphoglycerate mutase activity
Heal19_RS14785	COG0477	Major facilitator Superfamily
Heal19_RS14800	COG0656	L-ascorbic acid biosynthetic process
Heal19_RS14805	COG1376	ErfK ybiS ycfS ynhG family protein
Heal19_RS14820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Heal19_RS14830	COG0577	efflux transmembrane transporter activity
Heal19_RS14830	COG1136	(ABC) transporter
Heal19_RS14845	COG0693	protein deglycase activity
Heal19_RS14865	COG0789	Transcriptional regulator
Heal19_RS14880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS14885	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS14895	COG0783	Belongs to the Dps family
Heal19_RS14905	COG1053	succinate dehydrogenase
Heal19_RS14905	COG0431	NADPH-dependent FMN reductase
Heal19_RS14905	COG3976	FMN-binding domain protein
Heal19_RS14915	COG2816	NAD+ diphosphatase activity
Heal19_RS14925	COG0481	GTPase activity
Heal19_RS14960	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS14965	COG0110	maltose O-acetyltransferase activity
Heal19_RS14970	COG4221	oxidoreductase activity
Heal19_RS14980	COG1309	transcriptional regulator
Heal19_RS14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Heal19_RS14990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Heal19_RS14995	COG1120	ATPase activity
Heal19_RS15000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Heal19_RS15010	COG0477	Major facilitator Superfamily
Heal19_RS15015	COG0667	Aldo Keto reductase
Heal19_RS15035	COG0300	oxidoreductase activity
Heal19_RS15040	COG1733	regulation of RNA biosynthetic process
Heal19_RS15055	COG1012	belongs to the aldehyde dehydrogenase family
Heal19_RS15065	COG1309	transcriptional regulator
Heal19_RS15075	COG3279	Response regulator of the LytR AlgR family
Heal19_RS15080	COG0367	asparagine synthase
Heal19_RS15090	COG2814	Major facilitator Superfamily
Heal19_RS15095	COG1733	regulation of RNA biosynthetic process
Heal19_RS15110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Heal19_RS15150	COG1063	alcohol dehydrogenase
Heal19_RS15205	COG2217	Heavy metal translocating P-type atpase
Heal19_RS15225	COG0531	amino acid
Heal19_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS15245	COG1473	amidohydrolase
Heal19_RS15255	COG1132	(ABC) transporter
Heal19_RS15260	COG1132	(ABC) transporter
Heal19_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
Heal19_RS15305	COG4221	oxidoreductase activity
Heal19_RS15320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Heal19_RS15345	COG0803	Belongs to the bacterial solute-binding protein 9 family
Heal19_RS15365	COG0741	lytic transglycosylase activity
Heal19_RS15370	COG0789	Transcriptional regulator
Heal19_RS15380	COG2723	6-phospho-beta-galactosidase activity
Heal19_RS15385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS15390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Heal19_RS15425	COG0577	efflux transmembrane transporter activity
Heal19_RS15425	COG1136	(ABC) transporter
Heal19_RS15435	COG0640	Transcriptional regulator
Heal19_RS15455	COG1914	H( )-stimulated, divalent metal cation uptake system
Heal19_RS15470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Heal19_RS15470	COG5549	protein import
Heal19_RS15485	COG0559	Belongs to the binding-protein-dependent transport system permease family
Heal19_RS15500	COG0410	ABC transporter
Heal19_RS15535	COG4120	Belongs to the binding-protein-dependent transport system permease family
Heal19_RS15545	COG2190	(PTS) system
Heal19_RS15545	COG1263	PTS System
Heal19_RS15545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Heal19_RS15550	COG0778	Nitroreductase
Heal19_RS15560	COG1132	(ABC) transporter
Heal19_RS15565	COG1940	carbohydrate kinase activity
Heal19_RS15590	COG0697	spore germination
Heal19_RS15635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Heal19_RS15645	COG0583	DNA-binding transcription factor activity
Heal19_RS15660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Heal19_RS15670	COG0242	peptide deformylase activity
Heal19_RS15680	COG1328	CTP reductase activity
Heal19_RS15690	COG2200	EAL domain
Heal19_RS15730	COG2270	Major facilitator Superfamily
Heal19_RS15745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Heal19_RS15755	COG0561	phosphatase activity
Heal19_RS15760	COG0488	(ABC) transporter
Heal19_RS15790	COG0640	Transcriptional regulator