locus-tag	class	description
C4O30_RS00435	COG1611	Belongs to the LOG family
C4O30_RS00445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4O30_RS00450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4O30_RS00455	COG2813	Specifically methylates the guanine in position
C4O30_RS00470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4O30_RS00475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4O30_RS00480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4O30_RS00490	COG3711	transcriptional antiterminator
C4O30_RS00515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4O30_RS00520	COG3870	Protein conserved in bacteria
C4O30_RS00525	COG0470	DNA polymerase III
C4O30_RS00530	COG4467	Involved in initiation control of chromosome replication
C4O30_RS00545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4O30_RS00550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4O30_RS00555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4O30_RS00560	COG3639	organic phosphonate transmembrane transporter activity
C4O30_RS00570	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4O30_RS00580	COG1214	PFAM Peptidase M22, glycoprotease
C4O30_RS00585	COG0456	acetyltransferase
C4O30_RS00590	COG0456	acetyltransferase
C4O30_RS00595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4O30_RS00605	COG0488	(ABC) transporter
C4O30_RS00610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4O30_RS00620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4O30_RS00625	COG0459	protein refolding
C4O30_RS00630	COG0531	amino acid
C4O30_RS00635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4O30_RS00640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4O30_RS00645	COG1739	Uncharacterized protein family UPF0029
C4O30_RS00650	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C4O30_RS00665	COG0653	protein targeting
C4O30_RS00680	COG0745	RESPONSE REGULATOR receiver
C4O30_RS00685	COG5002	protein histidine kinase activity
C4O30_RS00690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4O30_RS00695	COG0573	inorganic phosphate transmembrane transporter activity
C4O30_RS00700	COG0581	inorganic phosphate transmembrane transporter activity
C4O30_RS00705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4O30_RS00710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4O30_RS00715	COG0704	Plays a role in the regulation of phosphate uptake
C4O30_RS00720	COG1983	PspC domain protein
C4O30_RS00725	COG1950	PFAM Membrane protein of
C4O30_RS00730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4O30_RS00735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4O30_RS00740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4O30_RS00745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4O30_RS00755	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS00775	COG1215	transferase activity, transferring glycosyl groups
C4O30_RS00790	COG0492	ferredoxin-NADP+ reductase activity
C4O30_RS00795	COG2323	membrane
C4O30_RS00805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4O30_RS00815	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS00825	COG2814	Major facilitator Superfamily
C4O30_RS00835	COG0556	nucleotide-excision repair
C4O30_RS00840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4O30_RS00845	COG1854	S-ribosylhomocysteine lyase activity
C4O30_RS00850	COG0137	argininosuccinate synthase activity
C4O30_RS00855	COG0165	Argininosuccinate lyase
C4O30_RS00865	COG1660	Displays ATPase and GTPase activities
C4O30_RS00875	COG1481	regulation of sporulation
C4O30_RS00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4O30_RS00890	COG0740	serine-type endopeptidase activity
C4O30_RS00900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4O30_RS00905	COG2390	Transcriptional regulator
C4O30_RS00915	COG0126	phosphoglycerate kinase activity
C4O30_RS00920	COG0149	triose-phosphate isomerase activity
C4O30_RS00925	COG0148	phosphopyruvate hydratase activity
C4O30_RS00940	COG0038	chloride channel
C4O30_RS00945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4O30_RS00955	COG0557	exoribonuclease II activity
C4O30_RS00960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4O30_RS00970	COG0765	amino acid transport
C4O30_RS00975	COG1126	abc transporter atp-binding protein
C4O30_RS00985	COG0561	phosphatase activity
C4O30_RS00990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4O30_RS00995	COG0280	phosphate acetyltransferase
C4O30_RS01000	COG0802	atpase or kinase
C4O30_RS01015	COG0708	Exodeoxyribonuclease III
C4O30_RS01025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4O30_RS01030	COG0025	NhaP-type Na H and K H
C4O30_RS01055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4O30_RS01060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4O30_RS01070	COG0561	phosphatase activity
C4O30_RS01080	COG2017	converts alpha-aldose to the beta-anomer
C4O30_RS01095	COG0778	Nitroreductase
C4O30_RS01120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4O30_RS01135	COG1393	Belongs to the ArsC family
C4O30_RS01150	COG2814	Major facilitator Superfamily
C4O30_RS01160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4O30_RS01170	COG3475	LICD family
C4O30_RS01185	COG2252	PERMEase
C4O30_RS01190	COG0028	Belongs to the TPP enzyme family
C4O30_RS01195	COG0196	riboflavin kinase activity
C4O30_RS01200	COG0028	Belongs to the TPP enzyme family
C4O30_RS01205	COG2267	carboxylic ester hydrolase activity
C4O30_RS01215	COG2755	lipolytic protein G-D-S-L family
C4O30_RS01215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4O30_RS01220	COG2936	dipeptidyl-peptidase activity
C4O30_RS01235	COG0531	amino acid
C4O30_RS01260	COG0194	GDP metabolic process
C4O30_RS01265	COG0735	belongs to the Fur family
C4O30_RS01280	COG0546	phosphoglycolate phosphatase activity
C4O30_RS01285	COG0436	Aminotransferase
C4O30_RS01290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4O30_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4O30_RS01315	COG0765	amino acid transport
C4O30_RS01320	COG0765	amino acid transport
C4O30_RS01325	COG1263	PTS System
C4O30_RS01325	COG2190	(PTS) system
C4O30_RS01325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS01335	COG1263	PTS System
C4O30_RS01340	COG3394	polysaccharide catabolic process
C4O30_RS01345	COG0531	amino acid
C4O30_RS01355	COG1846	Transcriptional regulator
C4O30_RS01385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4O30_RS01395	COG2076	Multidrug Resistance protein
C4O30_RS01410	COG0588	phosphoglycerate mutase activity
C4O30_RS01415	COG0569	domain protein
C4O30_RS01415	COG0475	glutathione-regulated potassium exporter activity
C4O30_RS01420	COG0456	acetyltransferase
C4O30_RS01420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4O30_RS01425	COG0586	Pfam SNARE associated Golgi protein
C4O30_RS01430	COG3973	AAA domain
C4O30_RS01435	COG2070	2-Nitropropane dioxygenase
C4O30_RS01440	COG1072	(Pantothenic acid kinase))
C4O30_RS01445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4O30_RS01445	COG0519	Catalyzes the synthesis of GMP from XMP
C4O30_RS01450	COG0464	growth
C4O30_RS01495	COG1396	sequence-specific DNA binding
C4O30_RS01500	COG1266	CAAX protease self-immunity
C4O30_RS01505	COG1733	regulation of RNA biosynthetic process
C4O30_RS01510	COG2814	Major facilitator Superfamily
C4O30_RS01525	COG2755	lipolytic protein G-D-S-L family
C4O30_RS01525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4O30_RS01530	COG2261	transglycosylase associated protein
C4O30_RS01545	COG1302	Protein conserved in bacteria
C4O30_RS01575	COG0308	aminopeptidase N
C4O30_RS01605	COG0572	uridine kinase
C4O30_RS01620	COG0583	DNA-binding transcription factor activity
C4O30_RS01625	COG1053	succinate dehydrogenase
C4O30_RS01635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4O30_RS01640	COG0017	Asparaginyl-tRNA synthetase
C4O30_RS01645	COG2502	aspartate--ammonia ligase
C4O30_RS01650	COG4690	dipeptidase activity
C4O30_RS01670	COG0514	ATP-dependent DNA helicase (RecQ)
C4O30_RS01675	COG0564	pseudouridine synthase activity
C4O30_RS01680	COG0640	Transcriptional regulator
C4O30_RS01730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4O30_RS01735	COG0527	aspartate kinase activity
C4O30_RS01740	COG0367	asparagine synthase
C4O30_RS01790	COG2814	Major facilitator Superfamily
C4O30_RS01810	COG1278	Cold shock
C4O30_RS01815	COG2966	Psort location CytoplasmicMembrane, score
C4O30_RS01825	COG1316	TRANSCRIPTIONal
C4O30_RS01845	COG1959	2 iron, 2 sulfur cluster binding
C4O30_RS01850	COG0028	Belongs to the TPP enzyme family
C4O30_RS01855	COG0833	amino acid
C4O30_RS01865	COG1428	Deoxynucleoside kinase
C4O30_RS01870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4O30_RS01910	COG4463	regulation of RNA biosynthetic process
C4O30_RS01915	COG0542	response to heat
C4O30_RS01925	COG0085	RNA polymerase activity
C4O30_RS01930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4O30_RS01935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4O30_RS01940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4O30_RS01945	COG0049	tRNA binding
C4O30_RS01950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4O30_RS01955	COG0051	transcription antitermination factor activity, RNA binding
C4O30_RS01960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4O30_RS01965	COG0088	Forms part of the polypeptide exit tunnel
C4O30_RS01970	COG0089	rRNA binding
C4O30_RS01975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4O30_RS01980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4O30_RS01985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4O30_RS01990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4O30_RS01995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4O30_RS02000	COG0255	Belongs to the universal ribosomal protein uL29 family
C4O30_RS02005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4O30_RS02010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4O30_RS02015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4O30_RS02020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4O30_RS02025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4O30_RS02030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4O30_RS02035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4O30_RS02040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4O30_RS02045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4O30_RS02050	COG1841	ribosomal large subunit assembly
C4O30_RS02055	COG0200	Binds to the 23S rRNA
C4O30_RS02065	COG0563	adenylate kinase activity
C4O30_RS02070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4O30_RS02075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4O30_RS02080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4O30_RS02085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4O30_RS02090	COG0202	RNA polymerase activity
C4O30_RS02095	COG0203	ribosomal protein L17
C4O30_RS02120	COG4939	FMN-binding domain protein
C4O30_RS02130	COG1122	ATPase activity
C4O30_RS02135	COG1122	ATPase activity
C4O30_RS02145	COG0101	tRNA pseudouridine synthase activity
C4O30_RS02150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4O30_RS02155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4O30_RS02175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4O30_RS02180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4O30_RS02185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4O30_RS02190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4O30_RS02195	COG0471	metal ion transport
C4O30_RS02200	COG2151	metal-sulfur cluster biosynthetic enzyme
C4O30_RS02205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4O30_RS02215	COG1917	Cupin 2, conserved barrel domain protein
C4O30_RS02215	COG4977	sequence-specific DNA binding
C4O30_RS02220	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4O30_RS02225	COG1121	(ABC) transporter
C4O30_RS02230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4O30_RS02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4O30_RS02245	COG0039	L-malate dehydrogenase activity
C4O30_RS02250	COG0471	metal ion transport
C4O30_RS02270	COG3052	prosthetic group binding
C4O30_RS02290	COG0114	fumarate hydratase activity
C4O30_RS02295	COG1053	succinate dehydrogenase
C4O30_RS02305	COG0583	DNA-binding transcription factor activity
C4O30_RS02310	COG0583	DNA-binding transcription factor activity
C4O30_RS02315	COG0281	malic enzyme
C4O30_RS02325	COG0531	amino acid
C4O30_RS02330	COG4684	Psort location CytoplasmicMembrane, score
C4O30_RS02345	COG1271	oxidase subunit
C4O30_RS02350	COG1294	oxidase, subunit
C4O30_RS02355	COG4988	ABC transporter
C4O30_RS02360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C4O30_RS02375	COG0142	geranyltranstransferase activity
C4O30_RS02390	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4O30_RS02395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4O30_RS02400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C4O30_RS02405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4O30_RS02415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4O30_RS02420	COG4851	CamS sex pheromone cAM373 precursor
C4O30_RS02425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4O30_RS02430	COG0154	amidase activity
C4O30_RS02435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4O30_RS02440	COG1597	lipid kinase activity
C4O30_RS02445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4O30_RS02460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS02470	COG1737	Transcriptional regulator
C4O30_RS02485	COG1278	Cold shock
C4O30_RS02490	COG0673	inositol 2-dehydrogenase activity
C4O30_RS02495	COG0513	Belongs to the DEAD box helicase family
C4O30_RS02510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS02535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4O30_RS02545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4O30_RS02555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS02560	COG0562	UDP-galactopyranose mutase
C4O30_RS02590	COG1442	glycosyl transferase family 8
C4O30_RS02590	COG1216	Glycosyl transferase, family 2
C4O30_RS02610	COG2244	polysaccharide biosynthetic process
C4O30_RS02645	COG2207	Transcriptional regulator
C4O30_RS02645	COG1609	Transcriptional regulator
C4O30_RS02665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4O30_RS02700	COG2137	regulation of response to DNA damage stimulus
C4O30_RS02705	COG3557	Belongs to the UPF0374 family
C4O30_RS02725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4O30_RS02735	COG0628	permease
C4O30_RS02740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4O30_RS02745	COG2610	gluconate transmembrane transporter activity
C4O30_RS02750	COG1070	Carbohydrate kinase
C4O30_RS02755	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4O30_RS02760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4O30_RS02765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4O30_RS02795	COG4166	transmembrane transport
C4O30_RS02800	COG0601	transmembrane transport
C4O30_RS02805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4O30_RS02810	COG0444	Belongs to the ABC transporter superfamily
C4O30_RS02815	COG4608	Belongs to the ABC transporter superfamily
C4O30_RS02825	COG0582	viral genome integration into host DNA
C4O30_RS02830	COG0542	response to heat
C4O30_RS02850	COG0438	transferase activity, transferring glycosyl groups
C4O30_RS02855	COG0438	transferase activity, transferring glycosyl groups
C4O30_RS02865	COG1686	Belongs to the peptidase S11 family
C4O30_RS02870	COG0436	Aminotransferase
C4O30_RS02875	COG4703	Protein of unknown function (DUF1797)
C4O30_RS02880	COG1368	sulfuric ester hydrolase activity
C4O30_RS02970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4O30_RS02990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4O30_RS03005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4O30_RS03010	COG0833	amino acid
C4O30_RS03015	COG2040	homocysteine
C4O30_RS03020	COG0438	transferase activity, transferring glycosyl groups
C4O30_RS03030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4O30_RS03035	COG0477	Major facilitator Superfamily
C4O30_RS03050	COG0438	transferase activity, transferring glycosyl groups
C4O30_RS03065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C4O30_RS03075	COG0495	leucyl-tRNA aminoacylation
C4O30_RS03080	COG2244	polysaccharide biosynthetic process
C4O30_RS03085	COG1187	pseudouridine synthase activity
C4O30_RS03095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4O30_RS03105	COG3842	ATPase activity
C4O30_RS03110	COG1175	transmembrane transport
C4O30_RS03115	COG0395	ABC-type sugar transport system, permease component
C4O30_RS03130	COG1428	Deoxynucleoside kinase
C4O30_RS03135	COG1970	mechanosensitive ion channel activity
C4O30_RS03140	COG1511	domain protein
C4O30_RS03140	COG1511	domain protein
C4O30_RS03170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4O30_RS03175	COG0789	Transcriptional regulator
C4O30_RS03185	COG0697	spore germination
C4O30_RS03190	COG0561	phosphatase activity
C4O30_RS03210	COG3279	Response regulator of the LytR AlgR family
C4O30_RS03230	COG1846	Transcriptional regulator
C4O30_RS03245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4O30_RS03285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4O30_RS03285	COG0646	methionine synthase
C4O30_RS03290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4O30_RS03300	COG2046	Belongs to the sulfate adenylyltransferase family
C4O30_RS03305	COG0529	Catalyzes the synthesis of activated sulfate
C4O30_RS03310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4O30_RS03320	COG0471	metal ion transport
C4O30_RS03320	COG3273	potassium ion transport
C4O30_RS03325	COG0534	Mate efflux family protein
C4O30_RS03345	COG2153	protein acetylation
C4O30_RS03350	COG0018	arginyl-trna synthetase
C4O30_RS03360	COG1136	(ABC) transporter
C4O30_RS03360	COG0577	efflux transmembrane transporter activity
C4O30_RS03380	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4O30_RS03385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS03390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS03395	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS03405	COG1376	ErfK ybiS ycfS ynhG family protein
C4O30_RS03410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4O30_RS03415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4O30_RS03425	COG0436	Aminotransferase
C4O30_RS03430	COG1438	arginine binding
C4O30_RS03440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4O30_RS03445	COG3679	Belongs to the UPF0342 family
C4O30_RS03450	COG0420	3'-5' exonuclease activity
C4O30_RS03455	COG4717	serine-type aminopeptidase activity
C4O30_RS03460	COG3481	metal-dependent phosphohydrolase, HD sub domain
C4O30_RS03475	COG0583	DNA-binding transcription factor activity
C4O30_RS03485	COG1053	succinate dehydrogenase
C4O30_RS03485	COG3976	FMN-binding domain protein
C4O30_RS03485	COG0431	NADPH-dependent FMN reductase
C4O30_RS03540	COG0148	phosphopyruvate hydratase activity
C4O30_RS03550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4O30_RS03560	COG0463	Glycosyl transferase, family 2
C4O30_RS03580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4O30_RS03580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4O30_RS03585	COG0307	riboflavin synthase, alpha
C4O30_RS03590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4O30_RS03590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4O30_RS03595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4O30_RS03610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4O30_RS03620	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS03650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4O30_RS03660	COG0537	adenosine 5'-monophosphoramidase activity
C4O30_RS03665	COG1131	(ABC) transporter
C4O30_RS03670	COG4473	ABC transporter
C4O30_RS03675	COG0510	thiamine kinase activity
C4O30_RS03680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4O30_RS03690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4O30_RS03695	COG1674	ftsk spoiiie
C4O30_RS03700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4O30_RS03725	COG0719	Fe-S assembly protein
C4O30_RS03730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4O30_RS03740	COG0719	Fe-S assembly protein
C4O30_RS03745	COG2151	metal-sulfur cluster biosynthetic enzyme
C4O30_RS03760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4O30_RS03760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4O30_RS03765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4O30_RS03770	COG0237	dephospho-CoA kinase activity
C4O30_RS03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4O30_RS03780	COG3611	Membrane attachment protein
C4O30_RS03785	COG1484	DNA-dependent DNA replication
C4O30_RS03790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4O30_RS03795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4O30_RS03800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4O30_RS03805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4O30_RS03815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4O30_RS03820	COG0604	alcohol dehydrogenase
C4O30_RS03825	COG1733	regulation of RNA biosynthetic process
C4O30_RS03835	COG1215	transferase activity, transferring glycosyl groups
C4O30_RS03850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4O30_RS03855	COG1534	Rna-binding protein
C4O30_RS03860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4O30_RS03865	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4O30_RS03870	COG0799	negative regulation of ribosome biogenesis
C4O30_RS03875	COG2226	methyltransferase
C4O30_RS03880	COG1323	Belongs to the UPF0348 family
C4O30_RS03890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4O30_RS03905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4O30_RS03910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4O30_RS03915	COG0745	RESPONSE REGULATOR receiver
C4O30_RS03920	COG5002	protein histidine kinase activity
C4O30_RS03945	COG0706	membrane insertase activity
C4O30_RS03950	COG1254	Belongs to the acylphosphatase family
C4O30_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4O30_RS03965	COG1733	regulation of RNA biosynthetic process
C4O30_RS03970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4O30_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4O30_RS03975	COG0072	phenylalanine-tRNA ligase activity
C4O30_RS03980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4O30_RS03985	COG0572	uridine kinase
C4O30_RS03990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4O30_RS04010	COG4841	protein insertion into membrane
C4O30_RS04020	COG0768	penicillin binding
C4O30_RS04025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4O30_RS04030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4O30_RS04035	COG0705	Rhomboid family
C4O30_RS04035	COG0457	Tetratricopeptide repeat
C4O30_RS04045	COG1940	carbohydrate kinase activity
C4O30_RS04065	COG0584	glycerophosphoryl diester phosphodiesterase
C4O30_RS04070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4O30_RS04075	COG0789	Transcriptional regulator
C4O30_RS04125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4O30_RS04135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4O30_RS04140	COG0006	proline dipeptidase activity
C4O30_RS04145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4O30_RS04150	COG1302	Protein conserved in bacteria
C4O30_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4O30_RS04160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4O30_RS04165	COG1570	exodeoxyribonuclease VII activity
C4O30_RS04170	COG1722	exodeoxyribonuclease VII activity
C4O30_RS04175	COG0142	geranyltranstransferase activity
C4O30_RS04180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4O30_RS04185	COG1438	arginine binding
C4O30_RS04190	COG0497	DNA recombination
C4O30_RS04205	COG1732	Glycine betaine
C4O30_RS04220	COG0194	GDP metabolic process
C4O30_RS04225	COG1758	RNA polymerase activity
C4O30_RS04230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4O30_RS04235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4O30_RS04240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4O30_RS04245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4O30_RS04245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4O30_RS04250	COG0631	protein serine/threonine phosphatase activity
C4O30_RS04255	COG2815	serine threonine protein kinase
C4O30_RS04255	COG0515	serine threonine protein kinase
C4O30_RS04260	COG1162	GTPase activity
C4O30_RS04265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4O30_RS04270	COG1564	THIamine pyrophosphokinase
C4O30_RS04280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4O30_RS04285	COG1302	Protein conserved in bacteria
C4O30_RS04290	COG1461	Dihydroxyacetone kinase
C4O30_RS04295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4O30_RS04300	COG0416	fatty acid biosynthetic process
C4O30_RS04305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4O30_RS04310	COG0571	ribonuclease III activity
C4O30_RS04315	COG1196	nuclear chromosome segregation
C4O30_RS04320	COG0552	protein localization to endoplasmic reticulum
C4O30_RS04325	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C4O30_RS04330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4O30_RS04335	COG0228	four-way junction DNA binding
C4O30_RS04340	COG1837	Belongs to the UPF0109 family
C4O30_RS04345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4O30_RS04350	COG0336	Belongs to the RNA methyltransferase TrmD family
C4O30_RS04355	COG0335	large ribosomal subunit rRNA binding
C4O30_RS04390	COG0512	Glutamine amidotransferase of anthranilate synthase
C4O30_RS04390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4O30_RS04395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4O30_RS04400	COG0134	indole-3-glycerol-phosphate synthase activity
C4O30_RS04405	COG0135	phosphoribosylanthranilate isomerase activity
C4O30_RS04410	COG0133	tryptophan synthase activity
C4O30_RS04415	COG0159	tryptophan synthase activity
C4O30_RS04430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4O30_RS04440	COG1473	amidohydrolase
C4O30_RS04445	COG1063	alcohol dehydrogenase
C4O30_RS04455	COG0300	oxidoreductase activity
C4O30_RS04465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4O30_RS04470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4O30_RS04475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4O30_RS04480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4O30_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS04490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4O30_RS04505	COG0439	Biotin carboxylase
C4O30_RS04520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4O30_RS04530	COG1811	Na channel or pump
C4O30_RS04535	COG0583	DNA-binding transcription factor activity
C4O30_RS04540	COG1607	acyl-coa hydrolase
C4O30_RS04545	COG1162	GTPase activity
C4O30_RS04555	COG0477	Major facilitator Superfamily
C4O30_RS04565	COG0582	viral genome integration into host DNA
C4O30_RS04605	COG1396	sequence-specific DNA binding
C4O30_RS04620	COG1396	sequence-specific DNA binding
C4O30_RS04705	COG3728	DNA packaging
C4O30_RS04705	COG5484	DNA packaging
C4O30_RS04810	COG3942	CHAP domain
C4O30_RS04810	COG1388	LysM domain
C4O30_RS04835	COG3397	chitin binding
C4O30_RS04840	COG3409	Peptidoglycan-binding domain 1 protein
C4O30_RS04900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4O30_RS04905	COG3397	chitin binding
C4O30_RS04920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4O30_RS04930	COG3152	Membrane
C4O30_RS04950	COG2261	transglycosylase associated protein
C4O30_RS04955	COG3237	CsbD-like
C4O30_RS04970	COG1942	4-Oxalocrotonate Tautomerase
C4O30_RS05010	COG0531	amino acid
C4O30_RS05015	COG0561	phosphatase activity
C4O30_RS05020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4O30_RS05020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C4O30_RS05040	COG2017	converts alpha-aldose to the beta-anomer
C4O30_RS05070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4O30_RS05070	COG1199	ATP-dependent helicase activity
C4O30_RS05085	COG0017	Asparaginyl-tRNA synthetase
C4O30_RS05100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4O30_RS05105	COG2011	ABC-type metal ion transport system permease component
C4O30_RS05110	COG1464	Belongs to the NlpA lipoprotein family
C4O30_RS05120	COG1177	transmembrane transport
C4O30_RS05125	COG1840	ABC-type Fe3 transport system, periplasmic component
C4O30_RS05140	COG3331	DNA recombination
C4O30_RS05145	COG4474	Belongs to the UPF0398 family
C4O30_RS05150	COG3599	regulation of cell shape
C4O30_RS05160	COG0116	Belongs to the methyltransferase superfamily
C4O30_RS05170	COG0477	Major facilitator Superfamily
C4O30_RS05175	COG1073	alpha beta
C4O30_RS05185	COG1216	Glycosyl transferase, family 2
C4O30_RS05205	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4O30_RS05230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4O30_RS05245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4O30_RS05250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4O30_RS05255	COG0564	pseudouridine synthase activity
C4O30_RS05260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4O30_RS05265	COG0505	Belongs to the CarA family
C4O30_RS05270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4O30_RS05285	COG5646	InterPro IPR014922
C4O30_RS05310	COG1131	(ABC) transporter
C4O30_RS05315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C4O30_RS05320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C4O30_RS05330	COG1307	EDD domain protein, DegV family
C4O30_RS05390	COG1113	amino acid transport
C4O30_RS05415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4O30_RS05440	COG1846	Transcriptional regulator
C4O30_RS05445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4O30_RS05635	COG4974	Belongs to the 'phage' integrase family
C4O30_RS05650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4O30_RS05655	COG1227	inorganic diphosphatase activity
C4O30_RS05660	COG0583	DNA-binding transcription factor activity
C4O30_RS05670	COG0187	DNA topoisomerase II activity
C4O30_RS05675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4O30_RS05690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4O30_RS05695	COG4974	Belongs to the 'phage' integrase family
C4O30_RS05700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C4O30_RS05705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4O30_RS05710	COG0758	DNA mediated transformation
C4O30_RS05715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4O30_RS05720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4O30_RS05730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4O30_RS05735	COG0583	DNA-binding transcription factor activity
C4O30_RS05755	COG2814	Major facilitator Superfamily
C4O30_RS05760	COG0793	Belongs to the peptidase S41A family
C4O30_RS05760	COG3409	Peptidoglycan-binding domain 1 protein
C4O30_RS05765	COG4479	Belongs to the UPF0346 family
C4O30_RS05770	COG4698	Protein conserved in bacteria
C4O30_RS05775	COG2755	lipolytic protein G-D-S-L family
C4O30_RS05780	COG1307	EDD domain protein, DegV family
C4O30_RS05785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4O30_RS05790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4O30_RS05795	COG0488	(ABC) transporter
C4O30_RS05805	COG0617	tRNA 3'-terminal CCA addition
C4O30_RS05810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4O30_RS05815	COG0561	phosphatase activity
C4O30_RS05820	COG0457	Tetratricopeptide repeat
C4O30_RS05835	COG1160	GTP binding
C4O30_RS05840	COG0539	negative regulation of cytoplasmic translation
C4O30_RS05845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4O30_RS05855	COG0514	ATP-dependent DNA helicase (RecQ)
C4O30_RS05865	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C4O30_RS05870	COG1187	pseudouridine synthase activity
C4O30_RS05875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4O30_RS05880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4O30_RS05890	COG4974	Belongs to the 'phage' integrase family
C4O30_RS05895	COG2996	Protein conserved in bacteria
C4O30_RS05910	COG0205	6-phosphofructokinase activity
C4O30_RS05915	COG0587	DNA-directed DNA polymerase activity
C4O30_RS05925	COG0542	response to heat
C4O30_RS05935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4O30_RS05940	COG2384	SAM-dependent methyltransferase
C4O30_RS05965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4O30_RS05965	COG0574	Belongs to the PEP-utilizing enzyme family
C4O30_RS05975	COG1846	Transcriptional regulator
C4O30_RS05995	COG2217	Heavy metal translocating P-type atpase
C4O30_RS06000	COG0148	phosphopyruvate hydratase activity
C4O30_RS06005	COG0477	Major facilitator Superfamily
C4O30_RS06015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4O30_RS06025	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS06030	COG1349	DNA-binding transcription factor activity
C4O30_RS06040	COG1393	Belongs to the ArsC family
C4O30_RS06085	COG0546	phosphoglycolate phosphatase activity
C4O30_RS06115	COG0583	DNA-binding transcription factor activity
C4O30_RS06120	COG0604	alcohol dehydrogenase
C4O30_RS06130	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS06135	COG2197	response regulator
C4O30_RS06140	COG4585	Histidine kinase
C4O30_RS06150	COG1131	(ABC) transporter
C4O30_RS06160	COG0519	Catalyzes the synthesis of GMP from XMP
C4O30_RS06175	COG1131	(ABC) transporter
C4O30_RS06195	COG1131	(ABC) transporter
C4O30_RS06210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4O30_RS06215	COG0358	DNA primase activity
C4O30_RS06220	COG0751	glycine-tRNA ligase activity
C4O30_RS06225	COG0752	glycyl-tRNA synthetase alpha subunit
C4O30_RS06230	COG1381	Involved in DNA repair and RecF pathway recombination
C4O30_RS06235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4O30_RS06240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4O30_RS06245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4O30_RS06250	COG1702	phosphate starvation-inducible protein PhoH
C4O30_RS06255	COG1610	YqeY-like protein
C4O30_RS06260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4O30_RS06265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4O30_RS06275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4O30_RS06285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4O30_RS06295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4O30_RS06300	COG0124	histidyl-tRNA synthetase
C4O30_RS06305	COG3103	Sh3 type 3 domain protein
C4O30_RS06305	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4O30_RS06305	COG4991	sh3 domain protein
C4O30_RS06310	COG3001	Fructosamine kinase
C4O30_RS06315	COG0546	phosphoglycolate phosphatase activity
C4O30_RS06320	COG1490	D-aminoacyl-tRNA deacylase activity
C4O30_RS06325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4O30_RS06335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4O30_RS06340	COG2264	protein methyltransferase activity
C4O30_RS06345	COG2094	Belongs to the DNA glycosylase MPG family
C4O30_RS06360	COG0481	GTPase activity
C4O30_RS06365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C4O30_RS06370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4O30_RS06375	COG1696	Membrane protein involved in D-alanine export
C4O30_RS06380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4O30_RS06390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4O30_RS06395	COG0484	heat shock protein binding
C4O30_RS06400	COG0443	Heat shock 70 kDa protein
C4O30_RS06405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4O30_RS06410	COG1420	regulation of RNA biosynthetic process
C4O30_RS06415	COG3527	Alpha-acetolactate decarboxylase
C4O30_RS06420	COG0196	riboflavin kinase activity
C4O30_RS06425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4O30_RS06430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4O30_RS06435	COG0287	Prephenate dehydrogenase
C4O30_RS06440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4O30_RS06450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4O30_RS06455	COG0738	Major facilitator superfamily
C4O30_RS06460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4O30_RS06465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4O30_RS06475	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C4O30_RS06480	COG0195	Participates in both transcription termination and antitermination
C4O30_RS06485	COG0779	Required for maturation of 30S ribosomal subunits
C4O30_RS06490	COG2176	DNA-directed DNA polymerase activity
C4O30_RS06495	COG0442	prolyl-tRNA aminoacylation
C4O30_RS06500	COG0750	zinc metalloprotease
C4O30_RS06505	COG4589	Belongs to the CDS family
C4O30_RS06510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4O30_RS06515	COG0233	cytoplasmic translational termination
C4O30_RS06520	COG0528	UMP kinase activity
C4O30_RS06525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4O30_RS06530	COG0052	Belongs to the universal ribosomal protein uS2 family
C4O30_RS06545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4O30_RS06550	COG2827	Endonuclease containing a URI domain
C4O30_RS06555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4O30_RS06560	COG0204	Acyl-transferase
C4O30_RS06565	COG3763	UPF0154 protein
C4O30_RS06570	COG4224	UPF0291 protein
C4O30_RS06575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4O30_RS06585	COG3425	synthase
C4O30_RS06600	COG0463	Glycosyl transferase, family 2
C4O30_RS06610	COG1316	TRANSCRIPTIONal
C4O30_RS06615	COG1116	anion transmembrane transporter activity
C4O30_RS06625	COG0772	Belongs to the SEDS family
C4O30_RS06645	COG0393	Putative heavy-metal-binding
C4O30_RS06660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4O30_RS06665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4O30_RS06665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4O30_RS06670	COG5416	Lipopolysaccharide assembly protein A domain
C4O30_RS06675	COG0300	oxidoreductase activity
C4O30_RS06680	COG1234	tRNA 3'-trailer cleavage
C4O30_RS06690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4O30_RS06695	COG1349	DNA-binding transcription factor activity
C4O30_RS06700	COG1105	Belongs to the carbohydrate kinase PfkB family
C4O30_RS06705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS06705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS06705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS06710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4O30_RS06735	COG0297	glycogen (starch) synthase activity
C4O30_RS06740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4O30_RS06745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4O30_RS06755	COG0489	protein tyrosine kinase activity
C4O30_RS06765	COG0322	excinuclease ABC activity
C4O30_RS06770	COG1126	abc transporter atp-binding protein
C4O30_RS06775	COG0765	amino acid transport
C4O30_RS06795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4O30_RS06800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4O30_RS06805	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4O30_RS06810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4O30_RS06830	COG2814	Major facilitator Superfamily
C4O30_RS06835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4O30_RS06840	COG0268	Binds directly to 16S ribosomal RNA
C4O30_RS06845	COG1466	dna polymerase III delta subunit
C4O30_RS06850	COG2333	competence protein COMEC
C4O30_RS06850	COG0658	competence protein
C4O30_RS06855	COG2131	deaminase
C4O30_RS06860	COG1555	photosystem II stabilization
C4O30_RS06860	COG1596	polysaccharide export
C4O30_RS06865	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4O30_RS06870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4O30_RS06875	COG0742	ribosomal rna small subunit methyltransferase
C4O30_RS06880	COG4471	UPF0298 protein
C4O30_RS06885	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C4O30_RS06890	COG0772	Belongs to the SEDS family
C4O30_RS06925	COG1217	gtp-binding protein TYPA
C4O30_RS06930	COG0483	inositol monophosphate 1-phosphatase activity
C4O30_RS06935	COG4476	Belongs to the UPF0223 family
C4O30_RS06940	COG0039	L-malate dehydrogenase activity
C4O30_RS06965	COG0242	peptide deformylase activity
C4O30_RS06975	COG5503	Protein of unknown function (DUF1447)
C4O30_RS06980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4O30_RS06985	COG1597	lipid kinase activity
C4O30_RS07000	COG3584	3D domain protein
C4O30_RS07000	COG1388	LysM domain
C4O30_RS07005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4O30_RS07010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4O30_RS07040	COG0569	domain protein
C4O30_RS07050	COG0482	sulfurtransferase activity
C4O30_RS07060	COG1104	cysteine desulfurase activity
C4O30_RS07065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4O30_RS07075	COG0494	nUDIX hydrolase
C4O30_RS07080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4O30_RS07085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4O30_RS07090	COG3599	regulation of cell shape
C4O30_RS07100	COG0762	integral membrane protein
C4O30_RS07105	COG1799	cell septum assembly
C4O30_RS07120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4O30_RS07125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4O30_RS07130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4O30_RS07135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4O30_RS07140	COG0768	penicillin binding
C4O30_RS07150	COG0275	rRNA processing
C4O30_RS07155	COG2001	Belongs to the MraZ family
C4O30_RS07175	COG1674	ftsk spoiiie
C4O30_RS07180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4O30_RS07190	COG1114	Component of the transport system for branched-chain amino acids
C4O30_RS07200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4O30_RS07205	COG0628	permease
C4O30_RS07215	COG2706	6-phosphogluconolactonase activity
C4O30_RS07220	COG3142	Participates in the control of copper homeostasis
C4O30_RS07225	COG0564	pseudouridine synthase activity
C4O30_RS07230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4O30_RS07235	COG2357	RelA SpoT domain protein
C4O30_RS07245	COG1164	Oligoendopeptidase f
C4O30_RS07255	COG4862	establishment of competence for transformation
C4O30_RS07260	COG1393	Belongs to the ArsC family
C4O30_RS07265	COG1234	tRNA 3'-trailer cleavage
C4O30_RS07405	COG1098	S1 RNA binding domain
C4O30_RS07415	COG0586	Pfam SNARE associated Golgi protein
C4O30_RS07425	COG0647	UMP catabolic process
C4O30_RS07430	COG4470	Protein conserved in bacteria
C4O30_RS07435	COG0737	Belongs to the 5'-nucleotidase family
C4O30_RS07450	COG1113	amino acid transport
C4O30_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4O30_RS07460	COG0827	DNA restriction-modification system
C4O30_RS07490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4O30_RS07500	COG0217	transcriptional regulatory protein
C4O30_RS07515	COG1609	Transcriptional regulator
C4O30_RS07520	COG0006	proline dipeptidase activity
C4O30_RS07525	COG0789	Transcriptional regulator
C4O30_RS07540	COG0668	transmembrane transport
C4O30_RS07545	COG1473	amidohydrolase
C4O30_RS07550	COG2171	N-acyltransferase activity
C4O30_RS07555	COG0517	IMP dehydrogenase activity
C4O30_RS07565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4O30_RS07570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4O30_RS07575	COG1719	4-vinyl reductase, 4VR
C4O30_RS07580	COG3118	belongs to the thioredoxin family
C4O30_RS07585	COG1193	negative regulation of DNA recombination
C4O30_RS07595	COG3906	Belongs to the UPF0473 family
C4O30_RS07600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4O30_RS07605	COG4472	Bacterial protein of unknown function (DUF965)
C4O30_RS07610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4O30_RS07615	COG0513	Belongs to the DEAD box helicase family
C4O30_RS07620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4O30_RS07625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4O30_RS07630	COG1862	Preprotein translocase
C4O30_RS07635	COG0343	queuine tRNA-ribosyltransferase activity
C4O30_RS07640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4O30_RS07645	COG2255	four-way junction helicase activity
C4O30_RS07650	COG0632	four-way junction helicase activity
C4O30_RS07685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4O30_RS07690	COG1692	metallophosphoesterase
C4O30_RS07695	COG1418	mRNA catabolic process
C4O30_RS07700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4O30_RS07705	COG1058	Belongs to the CinA family
C4O30_RS07705	COG1546	Belongs to the CinA family
C4O30_RS07710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4O30_RS07715	COG1426	Protein conserved in bacteria
C4O30_RS07720	COG0612	Peptidase, M16
C4O30_RS07725	COG0612	Peptidase, M16
C4O30_RS07730	COG0527	aspartate kinase activity
C4O30_RS07740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4O30_RS07745	COG1126	abc transporter atp-binding protein
C4O30_RS07750	COG0765	amino acid transport
C4O30_RS07755	COG2894	cell division
C4O30_RS07760	COG0850	regulation of cytokinetic process
C4O30_RS07770	COG1792	Involved in formation and maintenance of cell shape
C4O30_RS07775	COG1077	Cell shape determining protein MreB Mrl
C4O30_RS07780	COG2003	Belongs to the UPF0758 family
C4O30_RS07785	COG0285	dihydrofolate synthase activity
C4O30_RS07790	COG0525	valine-tRNA ligase activity
C4O30_RS07800	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4O30_RS07800	COG2918	glutathione biosynthetic process
C4O30_RS07805	COG0301	tRNA thio-modification
C4O30_RS07810	COG1104	cysteine desulfurase activity
C4O30_RS07820	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C4O30_RS07825	COG1956	GAF domain-containing protein
C4O30_RS07830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4O30_RS07835	COG4493	Belongs to the UPF0637 family
C4O30_RS07850	COG0640	Transcriptional regulator
C4O30_RS07855	COG0366	Alpha amylase catalytic
C4O30_RS07865	COG3716	PTS system mannose fructose sorbose family IID component
C4O30_RS07870	COG3715	PTS system
C4O30_RS07875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS07880	COG1609	Transcriptional regulator
C4O30_RS07885	COG0189	ligase activity
C4O30_RS07885	COG2918	glutathione biosynthetic process
C4O30_RS07890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4O30_RS07905	COG0589	response to stress
C4O30_RS07925	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4O30_RS07945	COG1464	Belongs to the NlpA lipoprotein family
C4O30_RS07950	COG2011	ABC-type metal ion transport system permease component
C4O30_RS07955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4O30_RS07960	COG0509	glycine decarboxylation via glycine cleavage system
C4O30_RS07965	COG0772	Belongs to the SEDS family
C4O30_RS07975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4O30_RS07980	COG1077	Cell shape determining protein MreB Mrl
C4O30_RS07990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4O30_RS07995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4O30_RS08000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4O30_RS08005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4O30_RS08010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4O30_RS08015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4O30_RS08020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4O30_RS08025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4O30_RS08030	COG0356	it plays a direct role in the translocation of protons across the membrane
C4O30_RS08035	COG2233	PERMEase
C4O30_RS08045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4O30_RS08050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4O30_RS08055	COG0009	L-threonylcarbamoyladenylate synthase
C4O30_RS08060	COG2890	protein-(glutamine-N5) methyltransferase activity
C4O30_RS08065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4O30_RS08070	COG1435	thymidine kinase activity
C4O30_RS08075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4O30_RS08080	COG3442	glutamine amidotransferase
C4O30_RS08085	COG1482	cell wall glycoprotein biosynthetic process
C4O30_RS08090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4O30_RS08100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4O30_RS08115	COG1132	(ABC) transporter
C4O30_RS08130	COG0726	polysaccharide deacetylase
C4O30_RS08250	COG2868	ribosomal protein
C4O30_RS08265	COG3728	DNA packaging
C4O30_RS08265	COG5484	DNA packaging
C4O30_RS08490	COG4932	domain protein
C4O30_RS08490	COG4886	Leucine-rich repeat (LRR) protein
C4O30_RS08535	COG1132	(ABC) transporter
C4O30_RS08545	COG1136	(ABC) transporter
C4O30_RS08545	COG0577	efflux transmembrane transporter activity
C4O30_RS08555	COG0166	Belongs to the GPI family
C4O30_RS08560	COG4975	Glucose uptake
C4O30_RS08565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4O30_RS08570	COG5002	protein histidine kinase activity
C4O30_RS08570	COG3850	Histidine kinase
C4O30_RS08575	COG0745	RESPONSE REGULATOR receiver
C4O30_RS08580	COG2848	UPF0210 protein
C4O30_RS08585	COG3830	Belongs to the UPF0237 family
C4O30_RS08610	COG0477	Major facilitator Superfamily
C4O30_RS08630	COG0791	NLP P60 protein
C4O30_RS08635	COG1522	sequence-specific DNA binding
C4O30_RS08655	COG0488	(ABC) transporter
C4O30_RS08685	COG1263	PTS System
C4O30_RS08685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS08685	COG2190	(PTS) system
C4O30_RS08690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4O30_RS08695	COG1307	EDD domain protein, DegV family
C4O30_RS08705	COG2873	o-acetylhomoserine
C4O30_RS08710	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C4O30_RS08735	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS08745	COG2084	Dehydrogenase
C4O30_RS08750	COG0861	Integral membrane protein TerC family
C4O30_RS08755	COG0110	maltose O-acetyltransferase activity
C4O30_RS08760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4O30_RS08765	COG0140	phosphoribosyl-ATP diphosphatase activity
C4O30_RS08770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4O30_RS08775	COG0107	imidazoleglycerol-phosphate synthase activity
C4O30_RS08780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4O30_RS08785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4O30_RS08790	COG0131	Imidazoleglycerol-phosphate dehydratase
C4O30_RS08795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4O30_RS08800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4O30_RS08805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4O30_RS08810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4O30_RS08830	COG0789	Transcriptional regulator
C4O30_RS08835	COG0300	oxidoreductase activity
C4O30_RS08845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4O30_RS08860	COG3548	integral membrane protein
C4O30_RS08880	COG1368	sulfuric ester hydrolase activity
C4O30_RS08885	COG0584	glycerophosphoryl diester phosphodiesterase
C4O30_RS08895	COG0492	ferredoxin-NADP+ reductase activity
C4O30_RS08905	COG4932	domain protein
C4O30_RS08910	COG2326	polyphosphate kinase activity
C4O30_RS08915	COG0778	Nitroreductase
C4O30_RS08925	COG0328	RNA-DNA hybrid ribonuclease activity
C4O30_RS08935	COG1609	Transcriptional regulator
C4O30_RS08945	COG0673	inositol 2-dehydrogenase activity
C4O30_RS08950	COG0673	inositol 2-dehydrogenase activity
C4O30_RS08955	COG0025	NhaP-type Na H and K H
C4O30_RS08960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4O30_RS08965	COG1335	isochorismatase
C4O30_RS08975	COG1131	(ABC) transporter
C4O30_RS08980	COG1725	Transcriptional regulator
C4O30_RS09020	COG0028	Belongs to the TPP enzyme family
C4O30_RS09030	COG1073	alpha beta
C4O30_RS09035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4O30_RS09040	COG0626	cystathionine gamma-synthase activity
C4O30_RS09070	COG0095	Lipoate-protein ligase
C4O30_RS09075	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4O30_RS09080	COG0589	response to stress
C4O30_RS09085	COG0564	pseudouridine synthase activity
C4O30_RS09100	COG4640	response to antibiotic
C4O30_RS09105	COG1396	sequence-specific DNA binding
C4O30_RS09120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4O30_RS09130	COG2188	Transcriptional regulator
C4O30_RS09135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4O30_RS09145	COG1418	mRNA catabolic process
C4O30_RS09175	COG1253	flavin adenine dinucleotide binding
C4O30_RS09180	COG1780	Probably involved in ribonucleotide reductase function
C4O30_RS09185	COG0025	NhaP-type Na H and K H
C4O30_RS09190	COG2814	Major facilitator Superfamily
C4O30_RS09195	COG0789	Transcriptional regulator
C4O30_RS09200	COG0604	alcohol dehydrogenase
C4O30_RS09210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4O30_RS09220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4O30_RS09225	COG0436	Aminotransferase
C4O30_RS09230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4O30_RS09245	COG0583	DNA-binding transcription factor activity
C4O30_RS09250	COG0702	epimerase
C4O30_RS09260	COG1074	ATP-dependent DNA helicase activity
C4O30_RS09265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C4O30_RS09275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4O30_RS09280	COG0284	orotidine-5'-phosphate decarboxylase activity
C4O30_RS09285	COG0167	dihydroorotate dehydrogenase activity
C4O30_RS09290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4O30_RS09295	COG0505	Belongs to the CarA family
C4O30_RS09300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4O30_RS09305	COG0540	Belongs to the ATCase OTCase family
C4O30_RS09310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4O30_RS09315	COG2508	Transcriptional regulator
C4O30_RS09320	COG2233	PERMEase
C4O30_RS09325	COG2252	PERMEase
C4O30_RS09345	COG1215	transferase activity, transferring glycosyl groups
C4O30_RS09355	COG0151	Belongs to the GarS family
C4O30_RS09360	COG0138	bifunctional purine biosynthesis protein purh
C4O30_RS09365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4O30_RS09370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4O30_RS09380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4O30_RS09385	COG0047	phosphoribosylformylglycinamidine synthase activity
C4O30_RS09390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4O30_RS09395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4O30_RS09400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4O30_RS09410	COG0431	NADPH-dependent FMN reductase
C4O30_RS09410	COG1053	succinate dehydrogenase
C4O30_RS09410	COG3976	FMN-binding domain protein
C4O30_RS09415	COG3976	FMN-binding domain protein
C4O30_RS09415	COG0431	NADPH-dependent FMN reductase
C4O30_RS09415	COG1053	succinate dehydrogenase
C4O30_RS09420	COG0095	Lipoate-protein ligase
C4O30_RS09425	COG2365	Tyrosine phosphatase family
C4O30_RS09445	COG1136	(ABC) transporter
C4O30_RS09460	COG1725	Transcriptional regulator
C4O30_RS09465	COG1131	(ABC) transporter
C4O30_RS09475	COG0589	response to stress
C4O30_RS09485	COG2246	polysaccharide biosynthetic process
C4O30_RS09505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4O30_RS09525	COG0366	Alpha amylase catalytic
C4O30_RS09535	COG0561	phosphatase activity
C4O30_RS09545	COG0110	maltose O-acetyltransferase activity
C4O30_RS09550	COG0494	nUDIX hydrolase
C4O30_RS09580	COG1827	regulation of RNA biosynthetic process
C4O30_RS09585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4O30_RS09590	COG1309	transcriptional regulator
C4O30_RS09600	COG1131	(ABC) transporter
C4O30_RS09605	COG3048	D-serine ammonia-lyase activity
C4O30_RS09610	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS09615	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS09620	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4O30_RS09625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS09630	COG2188	Transcriptional regulator
C4O30_RS09635	COG1216	Glycosyl transferase, family 2
C4O30_RS09650	COG0561	phosphatase activity
C4O30_RS09655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4O30_RS09680	COG0716	FMN binding
C4O30_RS09700	COG0710	3-dehydroquinate dehydratase activity
C4O30_RS09750	COG4720	Psort location CytoplasmicMembrane, score
C4O30_RS09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4O30_RS09770	COG4990	cell redox homeostasis
C4O30_RS09795	COG1811	Na channel or pump
C4O30_RS09800	COG0789	Transcriptional regulator
C4O30_RS09800	COG4978	Transcriptional regulator
C4O30_RS09815	COG0577	efflux transmembrane transporter activity
C4O30_RS09820	COG1136	(ABC) transporter
C4O30_RS09870	COG2814	Major facilitator Superfamily
C4O30_RS09880	COG2814	Major facilitator Superfamily
C4O30_RS09890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4O30_RS09895	COG2855	membrane
C4O30_RS09900	COG0583	DNA-binding transcription factor activity
C4O30_RS09910	COG0438	transferase activity, transferring glycosyl groups
C4O30_RS09925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4O30_RS09935	COG4152	abc transporter atp-binding protein
C4O30_RS09945	COG4221	oxidoreductase activity
C4O30_RS09960	COG0789	Transcriptional regulator
C4O30_RS09980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4O30_RS10005	COG0456	acetyltransferase
C4O30_RS10030	COG0583	DNA-binding transcription factor activity
C4O30_RS10040	COG1063	alcohol dehydrogenase
C4O30_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS10070	COG4975	Glucose uptake
C4O30_RS10080	COG0656	L-ascorbic acid biosynthetic process
C4O30_RS10085	COG0583	DNA-binding transcription factor activity
C4O30_RS10105	COG4221	oxidoreductase activity
C4O30_RS10110	COG0656	L-ascorbic acid biosynthetic process
C4O30_RS10130	COG0589	response to stress
C4O30_RS10135	COG0110	maltose O-acetyltransferase activity
C4O30_RS10140	COG1011	Hydrolase
C4O30_RS10155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4O30_RS10165	COG0667	Aldo Keto reductase
C4O30_RS10170	COG1132	(ABC) transporter
C4O30_RS10175	COG1132	(ABC) transporter
C4O30_RS10180	COG2814	Major facilitator Superfamily
C4O30_RS10195	COG1511	domain protein
C4O30_RS10195	COG1511	domain protein
C4O30_RS10205	COG0640	Transcriptional regulator
C4O30_RS10230	COG0488	(ABC) transporter
C4O30_RS10235	COG0561	phosphatase activity
C4O30_RS10245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4O30_RS10260	COG2270	Major facilitator Superfamily
C4O30_RS10300	COG2200	EAL domain
C4O30_RS10310	COG1328	CTP reductase activity
C4O30_RS10320	COG0242	peptide deformylase activity
C4O30_RS10330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4O30_RS10350	COG0583	DNA-binding transcription factor activity
C4O30_RS10360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4O30_RS10415	COG0697	spore germination
C4O30_RS10440	COG1940	carbohydrate kinase activity
C4O30_RS10445	COG1132	(ABC) transporter
C4O30_RS10455	COG0778	Nitroreductase
C4O30_RS10460	COG2190	(PTS) system
C4O30_RS10460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS10460	COG1263	PTS System
C4O30_RS10470	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4O30_RS10500	COG3620	sequence-specific DNA binding
C4O30_RS10500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4O30_RS10500	COG0617	tRNA 3'-terminal CCA addition
C4O30_RS10505	COG0410	ABC transporter
C4O30_RS10520	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4O30_RS10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4O30_RS10535	COG5549	protein import
C4O30_RS10540	COG2246	polysaccharide biosynthetic process
C4O30_RS10550	COG1914	H( )-stimulated, divalent metal cation uptake system
C4O30_RS10570	COG0640	Transcriptional regulator
C4O30_RS10585	COG1136	(ABC) transporter
C4O30_RS10585	COG0577	efflux transmembrane transporter activity
C4O30_RS10620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS10625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS10630	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS10640	COG0789	Transcriptional regulator
C4O30_RS10645	COG0741	lytic transglycosylase activity
C4O30_RS10665	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4O30_RS10690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4O30_RS10705	COG4221	oxidoreductase activity
C4O30_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS10750	COG1132	(ABC) transporter
C4O30_RS10755	COG1132	(ABC) transporter
C4O30_RS10765	COG1473	amidohydrolase
C4O30_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS10785	COG0531	amino acid
C4O30_RS10810	COG2217	Heavy metal translocating P-type atpase
C4O30_RS10870	COG1063	alcohol dehydrogenase
C4O30_RS10910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4O30_RS10925	COG1733	regulation of RNA biosynthetic process
C4O30_RS10930	COG2814	Major facilitator Superfamily
C4O30_RS10940	COG0367	asparagine synthase
C4O30_RS10945	COG3279	Response regulator of the LytR AlgR family
C4O30_RS10960	COG1309	transcriptional regulator
C4O30_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
C4O30_RS10985	COG1733	regulation of RNA biosynthetic process
C4O30_RS10990	COG0300	oxidoreductase activity
C4O30_RS11010	COG4989	oxidoreductase activity
C4O30_RS11015	COG0477	Major facilitator Superfamily
C4O30_RS11025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4O30_RS11030	COG1120	ATPase activity
C4O30_RS11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4O30_RS11040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4O30_RS11045	COG1309	transcriptional regulator
C4O30_RS11055	COG4221	oxidoreductase activity
C4O30_RS11060	COG0110	maltose O-acetyltransferase activity
C4O30_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS11105	COG0481	GTPase activity
C4O30_RS11120	COG2816	NAD+ diphosphatase activity
C4O30_RS11130	COG1053	succinate dehydrogenase
C4O30_RS11140	COG0783	Belongs to the Dps family
C4O30_RS11160	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS11165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS11165	COG2190	(PTS) system
C4O30_RS11165	COG1263	PTS System
C4O30_RS11190	COG3711	transcriptional antiterminator
C4O30_RS11220	COG1733	regulation of RNA biosynthetic process
C4O30_RS11235	COG1136	(ABC) transporter
C4O30_RS11235	COG0577	efflux transmembrane transporter activity
C4O30_RS11245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4O30_RS11260	COG1376	ErfK ybiS ycfS ynhG family protein
C4O30_RS11265	COG0656	L-ascorbic acid biosynthetic process
C4O30_RS11280	COG0477	Major facilitator Superfamily
C4O30_RS11310	COG0588	phosphoglycerate mutase activity
C4O30_RS11315	COG0628	permease
C4O30_RS11320	COG1846	Transcriptional regulator
C4O30_RS11320	COG1940	carbohydrate kinase activity
C4O30_RS11330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4O30_RS11340	COG0515	serine threonine protein kinase
C4O30_RS11340	COG2815	serine threonine protein kinase
C4O30_RS11380	COG1247	-acetyltransferase
C4O30_RS11385	COG1686	Belongs to the peptidase S11 family
C4O30_RS11405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4O30_RS11410	COG0516	GMP reductase activity
C4O30_RS11410	COG0517	IMP dehydrogenase activity
C4O30_RS11420	COG0012	GTP binding
C4O30_RS11425	COG4481	Protein conserved in bacteria
C4O30_RS11430	COG1475	DNA binding
C4O30_RS11435	COG1192	Involved in chromosome partitioning
C4O30_RS11445	COG0357	Ribosomal RNA small subunit methyltransferase G
C4O30_RS11450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4O30_RS11465	COG0583	DNA-binding transcription factor activity
C4O30_RS11470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4O30_RS11475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4O30_RS11480	COG0765	amino acid transport
C4O30_RS11485	COG1126	abc transporter atp-binding protein
C4O30_RS11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4O30_RS11515	COG2190	(PTS) system
C4O30_RS11515	COG1263	PTS System
C4O30_RS11515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS11520	COG0366	Alpha amylase catalytic
C4O30_RS11525	COG1609	Transcriptional regulator
C4O30_RS11535	COG0390	transport system, permease component
C4O30_RS11540	COG4619	ABC transporter
C4O30_RS11545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4O30_RS11560	COG0561	phosphatase activity
C4O30_RS11570	COG0383	alpha-mannosidase activity
C4O30_RS11575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS11575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS11575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS11580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS11585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS11585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS11585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS11590	COG3711	transcriptional antiterminator
C4O30_RS11590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS11605	COG2190	(PTS) system
C4O30_RS11605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS11605	COG1263	PTS System
C4O30_RS11635	COG0735	belongs to the Fur family
C4O30_RS11660	COG1380	Effector of murein hydrolase LrgA
C4O30_RS11670	COG1307	EDD domain protein, DegV family
C4O30_RS11680	COG2738	Putative neutral zinc metallopeptidase
C4O30_RS11685	COG1233	COG1233 Phytoene dehydrogenase and related
C4O30_RS11690	COG1562	ergosterol biosynthetic process
C4O30_RS11700	COG1929	Belongs to the glycerate kinase type-1 family
C4O30_RS11715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4O30_RS11720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4O30_RS11725	COG0516	GMP reductase activity
C4O30_RS11730	COG2365	Tyrosine phosphatase family
C4O30_RS11735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4O30_RS11745	COG0531	amino acid
C4O30_RS11750	COG3158	transport of potassium into the cell
C4O30_RS11760	COG0628	permease
C4O30_RS11765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4O30_RS11780	COG1272	protein, Hemolysin III
C4O30_RS11785	COG0640	Transcriptional regulator
C4O30_RS11820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4O30_RS11830	COG0302	gtp cyclohydrolase
C4O30_RS11835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4O30_RS11855	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4O30_RS11860	COG2814	Major facilitator Superfamily
C4O30_RS11890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4O30_RS11895	COG1882	Formate acetyltransferase
C4O30_RS11900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4O30_RS11910	COG2151	metal-sulfur cluster biosynthetic enzyme
C4O30_RS11915	COG4989	oxidoreductase activity
C4O30_RS11950	COG2217	Heavy metal translocating P-type atpase
C4O30_RS11960	COG2315	Protein conserved in bacteria
C4O30_RS11970	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4O30_RS11975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4O30_RS11985	COG1757	Na H antiporter
C4O30_RS11990	COG1113	amino acid transport
C4O30_RS12000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4O30_RS12020	COG1393	Belongs to the ArsC family
C4O30_RS12025	COG3189	MarR family transcriptional regulator
C4O30_RS12035	COG1194	a g-specific adenine glycosylase
C4O30_RS12050	COG0071	Belongs to the small heat shock protein (HSP20) family
C4O30_RS12070	COG0697	spore germination
C4O30_RS12085	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C4O30_RS12110	COG0477	Major facilitator Superfamily
C4O30_RS12175	COG0737	Belongs to the 5'-nucleotidase family
C4O30_RS12185	COG0656	L-ascorbic acid biosynthetic process
C4O30_RS12205	COG1968	undecaprenyl-diphosphatase activity
C4O30_RS12210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C4O30_RS12245	COG2207	Transcriptional regulator
C4O30_RS12270	COG0076	glutamate decarboxylase activity
C4O30_RS12320	COG2226	methyltransferase
C4O30_RS12335	COG2217	Heavy metal translocating P-type atpase
C4O30_RS12340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS12345	COG3118	belongs to the thioredoxin family
C4O30_RS12350	COG1937	Protein conserved in bacteria
C4O30_RS12370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4O30_RS12375	COG3590	peptidase
C4O30_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4O30_RS12450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS12460	COG1114	Component of the transport system for branched-chain amino acids
C4O30_RS12470	COG1874	Beta-galactosidase
C4O30_RS12475	COG1609	Transcriptional regulator
C4O30_RS12485	COG0477	Major facilitator Superfamily
C4O30_RS12505	COG2184	nucleotidyltransferase activity
C4O30_RS12510	COG2944	sequence-specific DNA binding
C4O30_RS12515	COG1609	Transcriptional regulator
C4O30_RS12520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C4O30_RS12525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4O30_RS12530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4O30_RS12550	COG2190	(PTS) system
C4O30_RS12550	COG2211	Major facilitator Superfamily
C4O30_RS12555	COG2017	converts alpha-aldose to the beta-anomer
C4O30_RS12560	COG1609	Transcriptional regulator
C4O30_RS12565	COG0667	Aldo Keto reductase
C4O30_RS12585	COG0710	3-dehydroquinate dehydratase activity
C4O30_RS12590	COG0738	Major facilitator superfamily
C4O30_RS12595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4O30_RS12600	COG0583	DNA-binding transcription factor activity
C4O30_RS12605	COG0738	Major facilitator superfamily
C4O30_RS12615	COG2267	carboxylic ester hydrolase activity
C4O30_RS12620	COG2188	Transcriptional regulator
C4O30_RS12625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS12630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4O30_RS12635	COG2971	BadF BadG BcrA BcrD
C4O30_RS12655	COG3711	transcriptional antiterminator
C4O30_RS12660	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS12665	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS12670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS12670	COG2190	(PTS) system
C4O30_RS12670	COG1263	PTS System
C4O30_RS12690	COG2211	Major facilitator Superfamily
C4O30_RS12705	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C4O30_RS12720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4O30_RS12725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4O30_RS12730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS12730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4O30_RS12730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS12735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4O30_RS12750	COG3711	transcriptional antiterminator
C4O30_RS12760	COG3775	system Galactitol-specific IIC component
C4O30_RS12765	COG3414	Phosphotransferase system galactitol-specific IIB component
C4O30_RS12775	COG1349	DNA-binding transcription factor activity
C4O30_RS12780	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C4O30_RS12785	COG1649	PFAM Uncharacterised BCR, COG1649
C4O30_RS12785	COG0726	polysaccharide deacetylase
C4O30_RS12800	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4O30_RS12830	COG2261	transglycosylase associated protein
C4O30_RS12840	COG1393	Belongs to the ArsC family
C4O30_RS12860	COG4512	PFAM Accessory gene regulator B
C4O30_RS12875	COG1304	FMN binding
C4O30_RS12880	COG0028	Belongs to the TPP enzyme family
C4O30_RS12885	COG1959	2 iron, 2 sulfur cluster binding
C4O30_RS12890	COG0028	Belongs to the TPP enzyme family
C4O30_RS12905	COG0235	Class ii aldolase
C4O30_RS12910	COG4806	L-rhamnose isomerase
C4O30_RS12915	COG3254	rhamnose metabolic process
C4O30_RS12925	COG2814	Major facilitator Superfamily
C4O30_RS12930	COG2207	Transcriptional regulator
C4O30_RS12935	COG1349	DNA-binding transcription factor activity
C4O30_RS13020	COG2207	Transcriptional regulator
C4O30_RS13020	COG1609	Transcriptional regulator
C4O30_RS13060	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS13065	COG1940	carbohydrate kinase activity
C4O30_RS13070	COG0383	alpha-mannosidase activity
C4O30_RS13080	COG2188	Transcriptional regulator
C4O30_RS13090	COG3842	ATPase activity
C4O30_RS13100	COG2207	Transcriptional regulator
C4O30_RS13100	COG4753	response regulator
C4O30_RS13105	COG2972	Histidine kinase
C4O30_RS13115	COG0366	Alpha amylase catalytic
C4O30_RS13120	COG1653	transport
C4O30_RS13125	COG0395	ABC-type sugar transport system, permease component
C4O30_RS13140	COG2207	Transcriptional regulator
C4O30_RS13140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4O30_RS13145	COG1132	(ABC) transporter
C4O30_RS13150	COG1132	(ABC) transporter
C4O30_RS13155	COG2188	Transcriptional regulator
C4O30_RS13170	COG3732	PTS system glucitol sorbitol-specific
C4O30_RS13175	COG3730	PTS system glucitol sorbitol-specific
C4O30_RS13195	COG4975	Glucose uptake
C4O30_RS13200	COG1869	D-ribose catabolic process
C4O30_RS13210	COG1609	Transcriptional regulator
C4O30_RS13220	COG2856	Zn peptidase
C4O30_RS13225	COG1454	alcohol dehydrogenase
C4O30_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
C4O30_RS13235	COG1695	Transcriptional regulator
C4O30_RS13240	COG3479	Phenolic acid decarboxylase
C4O30_RS13255	COG1307	EDD domain protein, DegV family
C4O30_RS13295	COG0445	tRNA wobble uridine modification
C4O30_RS13300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4O30_RS13305	COG1847	R3H domain protein
C4O30_RS13315	COG4166	transmembrane transport
C4O30_RS13320	COG0706	membrane insertase activity
C4O30_RS13325	COG0594	ribonuclease P activity
C4O30_RS13330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4O30_RS13335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4O30_RS13340	COG0592	DNA-directed DNA polymerase activity
C4O30_RS13345	COG2501	S4 domain
C4O30_RS13350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4O30_RS13355	COG0187	DNA topoisomerase II activity
C4O30_RS13365	COG0360	Binds together with S18 to 16S ribosomal RNA
C4O30_RS13370	COG0629	single-stranded DNA binding
C4O30_RS13375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4O30_RS13385	COG0359	binds to the 23S rRNA
C4O30_RS13390	COG0305	Participates in initiation and elongation during chromosome replication
C4O30_RS13395	COG2814	Major facilitator Superfamily
C4O30_RS13400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4O30_RS13405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4O30_RS13410	COG4166	transmembrane transport
C4O30_RS13420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4O30_RS13425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4O30_RS13430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4O30_RS13435	COG0297	glycogen (starch) synthase activity
C4O30_RS13440	COG0058	SHG alpha-glucan phosphorylase activity
C4O30_RS13445	COG0366	Alpha amylase catalytic
C4O30_RS13445	COG3103	Sh3 type 3 domain protein
C4O30_RS13455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4O30_RS13460	COG1554	hydrolase, family 65, central catalytic
C4O30_RS13470	COG1278	Cold shock
C4O30_RS13485	COG0745	RESPONSE REGULATOR receiver
C4O30_RS13490	COG5002	protein histidine kinase activity
C4O30_RS13500	COG4853	Protein conserved in bacteria
C4O30_RS13505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4O30_RS13510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4O30_RS13515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4O30_RS13525	COG1012	belongs to the aldehyde dehydrogenase family
C4O30_RS13535	COG1573	uracil-dna glycosylase
C4O30_RS13555	COG3976	FMN-binding domain protein
C4O30_RS13555	COG1053	succinate dehydrogenase
C4O30_RS13555	COG0431	NADPH-dependent FMN reductase
C4O30_RS13560	COG0471	metal ion transport
C4O30_RS13575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4O30_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS13590	COG0778	Nitroreductase
C4O30_RS13595	COG2508	Transcriptional regulator
C4O30_RS13605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4O30_RS13610	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C4O30_RS13620	COG2365	Tyrosine phosphatase family
C4O30_RS13625	COG2368	4-hydroxyphenylacetate
C4O30_RS13645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4O30_RS13680	COG0604	alcohol dehydrogenase
C4O30_RS13710	COG3022	response to hydroperoxide
C4O30_RS13720	COG4166	transmembrane transport
C4O30_RS13745	COG1122	ATPase activity
C4O30_RS13750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4O30_RS13755	COG0310	cobalt ion transport
C4O30_RS13760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4O30_RS13765	COG3875	lactate racemase activity
C4O30_RS13770	COG1691	(AIR) carboxylase
C4O30_RS13775	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4O30_RS13780	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4O30_RS13785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS13790	COG1606	tRNA processing
C4O30_RS13800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C4O30_RS13805	COG0351	phosphomethylpyrimidine kinase
C4O30_RS13810	COG0352	thiamine-phosphate diphosphorylase activity
C4O30_RS13820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4O30_RS13835	COG1113	amino acid transport
C4O30_RS13845	COG2267	carboxylic ester hydrolase activity
C4O30_RS13855	COG1983	PspC domain protein
C4O30_RS13895	COG2807	transmembrane transport
C4O30_RS13900	COG0656	L-ascorbic acid biosynthetic process
C4O30_RS13905	COG0667	Aldo Keto reductase
C4O30_RS13935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4O30_RS13940	COG1122	ATPase activity
C4O30_RS13945	COG4720	Psort location CytoplasmicMembrane, score
C4O30_RS13955	COG2188	Transcriptional regulator
C4O30_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
C4O30_RS13985	COG1131	(ABC) transporter
C4O30_RS14000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4O30_RS14005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C4O30_RS14010	COG1309	transcriptional regulator
C4O30_RS14015	COG2376	Dihydroxyacetone kinase
C4O30_RS14020	COG2376	Dihydroxyacetone kinase
C4O30_RS14025	COG1461	Dihydroxyacetone kinase
C4O30_RS14030	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C4O30_RS14035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS14040	COG1609	Transcriptional regulator
C4O30_RS14045	COG1609	Transcriptional regulator
C4O30_RS14050	COG0366	Alpha amylase catalytic
C4O30_RS14055	COG2182	Extracellular solute-binding protein
C4O30_RS14060	COG1175	transmembrane transport
C4O30_RS14065	COG3833	ABC-type maltose transport systems, permease component
C4O30_RS14075	COG0366	Alpha amylase catalytic
C4O30_RS14080	COG3842	ATPase activity
C4O30_RS14135	COG1757	Na H antiporter
C4O30_RS14160	COG4166	transmembrane transport
C4O30_RS14165	COG4166	transmembrane transport
C4O30_RS14175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4O30_RS14180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4O30_RS14185	COG0406	alpha-ribazole phosphatase activity
C4O30_RS14190	COG0667	Aldo Keto reductase
C4O30_RS14220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4O30_RS14225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4O30_RS14230	COG0488	(ABC) transporter
C4O30_RS14240	COG4172	Belongs to the ABC transporter superfamily
C4O30_RS14250	COG0386	Belongs to the glutathione peroxidase family
C4O30_RS14260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4O30_RS14275	COG0363	glucosamine-6-phosphate deaminase activity
C4O30_RS14285	COG2213	PTS system mannitol-specific
C4O30_RS14295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS14300	COG0246	Mannitol dehydrogenase
C4O30_RS14310	COG3118	belongs to the thioredoxin family
C4O30_RS14340	COG0431	NADPH-dependent FMN reductase
C4O30_RS14345	COG2188	Transcriptional regulator
C4O30_RS14355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS14370	COG3964	amidohydrolase
C4O30_RS14390	COG1045	serine acetyltransferase
C4O30_RS14395	COG0626	cystathionine gamma-synthase activity
C4O30_RS14400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4O30_RS14430	COG2188	Transcriptional regulator
C4O30_RS14435	COG0366	Alpha amylase catalytic
C4O30_RS14440	COG1263	PTS System
C4O30_RS14440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS14440	COG2190	(PTS) system
C4O30_RS14445	COG1263	PTS System
C4O30_RS14445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS14445	COG2190	(PTS) system
C4O30_RS14455	COG0163	prenyltransferase activity
C4O30_RS14465	COG1959	2 iron, 2 sulfur cluster binding
C4O30_RS14470	COG1309	transcriptional regulator
C4O30_RS14475	COG1914	H( )-stimulated, divalent metal cation uptake system
C4O30_RS14495	COG2814	Major facilitator Superfamily
C4O30_RS14505	COG5002	protein histidine kinase activity
C4O30_RS14510	COG0745	RESPONSE REGULATOR receiver
C4O30_RS14520	COG1737	Transcriptional regulator
C4O30_RS14525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS14540	COG1316	TRANSCRIPTIONal
C4O30_RS14545	COG0277	FAD linked oxidase domain protein
C4O30_RS14555	COG2357	RelA SpoT domain protein
C4O30_RS14565	COG1033	growth of symbiont in host cell
C4O30_RS14565	COG2409	Drug exporters of the RND superfamily
C4O30_RS14565	COG1033	growth of symbiont in host cell
C4O30_RS14565	COG2409	Drug exporters of the RND superfamily
C4O30_RS14570	COG2818	Glycosylase
C4O30_RS14580	COG0577	efflux transmembrane transporter activity
C4O30_RS14585	COG1136	(ABC) transporter
C4O30_RS14605	COG0741	lytic transglycosylase activity
C4O30_RS14610	COG1388	LysM domain
C4O30_RS14610	COG3942	CHAP domain
C4O30_RS14640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4O30_RS14650	COG1846	Transcriptional regulator
C4O30_RS14655	COG1252	NADH dehydrogenase
C4O30_RS14695	COG3842	ATPase activity
C4O30_RS14725	COG1725	Transcriptional regulator
C4O30_RS14730	COG1131	(ABC) transporter
C4O30_RS14740	COG1454	alcohol dehydrogenase
C4O30_RS14740	COG1012	belongs to the aldehyde dehydrogenase family
C4O30_RS14775	COG1268	BioY protein
C4O30_RS14800	COG2011	ABC-type metal ion transport system permease component
C4O30_RS14805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4O30_RS14810	COG0436	Aminotransferase
C4O30_RS14820	COG1682	transport, permease protein
C4O30_RS14825	COG1134	teichoic acid transport
C4O30_RS14840	COG2814	Major facilitator Superfamily
C4O30_RS14845	COG0004	ammonium transporteR
C4O30_RS14865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4O30_RS14875	COG3759	membrane
C4O30_RS14885	COG1881	PFAM PEBP family protein
C4O30_RS14915	COG0300	oxidoreductase activity
C4O30_RS14935	COG1125	glycine betaine transport
C4O30_RS14945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4O30_RS14955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4O30_RS15010	COG0110	maltose O-acetyltransferase activity
C4O30_RS15020	COG0561	phosphatase activity
C4O30_RS15030	COG0561	phosphatase activity
C4O30_RS15035	COG1114	Component of the transport system for branched-chain amino acids
C4O30_RS15060	COG0475	glutathione-regulated potassium exporter activity
C4O30_RS15105	COG3279	Response regulator of the LytR AlgR family
C4O30_RS15130	COG2274	protein secretion by the type I secretion system
C4O30_RS15165	COG3973	AAA domain
C4O30_RS15170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4O30_RS15175	COG0180	Tryptophanyl-tRNA synthetase
C4O30_RS15180	COG2188	Transcriptional regulator
C4O30_RS15185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS15200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4O30_RS15205	COG2723	6-phospho-beta-galactosidase activity
C4O30_RS15210	COG1940	carbohydrate kinase activity
C4O30_RS15220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4O30_RS15235	COG0248	Ppx GppA phosphatase
C4O30_RS15250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4O30_RS15255	COG1801	Protein of unknown function DUF72
C4O30_RS15265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4O30_RS15265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4O30_RS15270	COG2814	Major facilitator Superfamily
C4O30_RS15275	COG0084	hydrolase, TatD family'
C4O30_RS15280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4O30_RS15285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4O30_RS15290	COG4466	Protein conserved in bacteria
C4O30_RS15295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4O30_RS15300	COG1073	alpha beta
C4O30_RS15305	COG1121	(ABC) transporter
C4O30_RS15310	COG1321	iron dependent repressor
C4O30_RS15310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4O30_RS15335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4O30_RS15340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4O30_RS15350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4O30_RS15370	COG1078	dGTPase activity
C4O30_RS15375	COG0095	Lipoate-protein ligase
C4O30_RS15385	COG3343	RNA polymerase activity
C4O30_RS15390	COG0504	CTP synthase activity
C4O30_RS15395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4O30_RS15400	COG0814	amino acid
C4O30_RS15410	COG1760	l-serine dehydratase
C4O30_RS15415	COG1760	l-serine dehydratase
C4O30_RS15430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4O30_RS15435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4O30_RS15440	COG0254	rRNA binding
C4O30_RS15450	COG3764	Sortase (surface protein transpeptidase)
C4O30_RS15455	COG1704	LemA family
C4O30_RS15460	COG0501	Belongs to the peptidase M48B family
C4O30_RS15470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4O30_RS15490	COG0736	holo-[acyl-carrier-protein] synthase activity
C4O30_RS15495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4O30_RS15500	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4O30_RS15505	COG3158	transport of potassium into the cell
C4O30_RS15510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4O30_RS15515	COG0505	Belongs to the CarA family
C4O30_RS15520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4O30_RS15525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4O30_RS15530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4O30_RS15535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4O30_RS15540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4O30_RS15560	COG0039	L-malate dehydrogenase activity
C4O30_RS15565	COG0193	aminoacyl-tRNA hydrolase activity
C4O30_RS15570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4O30_RS15575	COG2244	polysaccharide biosynthetic process
C4O30_RS15580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4O30_RS15590	COG1098	S1 RNA binding domain
C4O30_RS15595	COG0037	tRNA processing
C4O30_RS15610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4O30_RS15615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4O30_RS15620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4O30_RS15660	COG3104	oligopeptide transport
C4O30_RS15710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4O30_RS15720	COG2188	Transcriptional regulator
C4O30_RS15730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4O30_RS15735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4O30_RS15750	COG2183	response to ionizing radiation
C4O30_RS15755	COG3091	SprT-like family
C4O30_RS15760	COG0460	homoserine dehydrogenase
C4O30_RS15765	COG0083	homoserine kinase activity
C4O30_RS15785	COG3715	PTS system
C4O30_RS15790	COG3716	PTS system mannose fructose sorbose family IID component
C4O30_RS15800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4O30_RS15800	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4O30_RS15805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4O30_RS15805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4O30_RS15815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4O30_RS15825	COG0439	Biotin carboxylase
C4O30_RS15835	COG0825	malonyl-CoA metabolic process
C4O30_RS15840	COG1316	TRANSCRIPTIONal
C4O30_RS15850	COG0697	spore germination
C4O30_RS15855	COG0588	phosphoglycerate mutase activity
C4O30_RS15870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4O30_RS15880	COG0756	dUTP diphosphatase activity
C4O30_RS15900	COG4956	integral membrane protein (PIN domain superfamily)
C4O30_RS15905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4O30_RS15910	COG0215	cysteine-tRNA ligase activity
C4O30_RS15915	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4O30_RS15920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4O30_RS15935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4O30_RS15945	COG0250	Participates in transcription elongation, termination and antitermination
C4O30_RS15955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4O30_RS15960	COG0081	regulation of translation
C4O30_RS15965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4O30_RS15970	COG0222	ribosome binding