locus-tag	class	description
B8X06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B8X06_RS00010	COG0592	DNA-directed DNA polymerase activity
B8X06_RS00015	COG2501	S4 domain
B8X06_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B8X06_RS00025	COG0187	DNA topoisomerase II activity
B8X06_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
B8X06_RS00040	COG0629	single-stranded DNA binding
B8X06_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B8X06_RS00055	COG0359	binds to the 23S rRNA
B8X06_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
B8X06_RS00065	COG2814	Major facilitator Superfamily
B8X06_RS00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B8X06_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B8X06_RS00080	COG4166	transmembrane transport
B8X06_RS00090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B8X06_RS00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B8X06_RS00100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B8X06_RS00105	COG0297	glycogen (starch) synthase activity
B8X06_RS00110	COG0058	SHG alpha-glucan phosphorylase activity
B8X06_RS00115	COG3103	Sh3 type 3 domain protein
B8X06_RS00115	COG0366	Alpha amylase catalytic
B8X06_RS00125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B8X06_RS00130	COG1554	hydrolase, family 65, central catalytic
B8X06_RS00140	COG1278	Cold shock
B8X06_RS00155	COG0745	RESPONSE REGULATOR receiver
B8X06_RS00160	COG5002	protein histidine kinase activity
B8X06_RS00170	COG4853	Protein conserved in bacteria
B8X06_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B8X06_RS00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B8X06_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B8X06_RS00205	COG1012	belongs to the aldehyde dehydrogenase family
B8X06_RS00210	COG1573	uracil-dna glycosylase
B8X06_RS00230	COG1053	succinate dehydrogenase
B8X06_RS00230	COG0431	NADPH-dependent FMN reductase
B8X06_RS00230	COG3976	FMN-binding domain protein
B8X06_RS00235	COG0471	metal ion transport
B8X06_RS00250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B8X06_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS00265	COG0778	Nitroreductase
B8X06_RS00270	COG2508	Transcriptional regulator
B8X06_RS00280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B8X06_RS00285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B8X06_RS00295	COG2365	Tyrosine phosphatase family
B8X06_RS00300	COG2368	4-hydroxyphenylacetate
B8X06_RS00320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B8X06_RS00355	COG0604	alcohol dehydrogenase
B8X06_RS00380	COG2267	carboxylic ester hydrolase activity
B8X06_RS00385	COG3022	response to hydroperoxide
B8X06_RS00395	COG4166	transmembrane transport
B8X06_RS00420	COG1122	ATPase activity
B8X06_RS00425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B8X06_RS00430	COG0310	cobalt ion transport
B8X06_RS00435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B8X06_RS00440	COG3875	lactate racemase activity
B8X06_RS00445	COG1691	(AIR) carboxylase
B8X06_RS00450	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B8X06_RS00455	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B8X06_RS00460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS00465	COG1606	tRNA processing
B8X06_RS00475	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B8X06_RS00480	COG0351	phosphomethylpyrimidine kinase
B8X06_RS00485	COG0352	thiamine-phosphate diphosphorylase activity
B8X06_RS00495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B8X06_RS00510	COG1113	amino acid transport
B8X06_RS00520	COG2267	carboxylic ester hydrolase activity
B8X06_RS00525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B8X06_RS00535	COG1983	PspC domain protein
B8X06_RS00575	COG2807	transmembrane transport
B8X06_RS00580	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS00585	COG0667	Aldo Keto reductase
B8X06_RS00615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B8X06_RS00620	COG1122	ATPase activity
B8X06_RS00625	COG4720	Psort location CytoplasmicMembrane, score
B8X06_RS00635	COG2188	Transcriptional regulator
B8X06_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS00665	COG1131	(ABC) transporter
B8X06_RS00680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B8X06_RS00685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B8X06_RS00690	COG1309	transcriptional regulator
B8X06_RS00695	COG2376	Dihydroxyacetone kinase
B8X06_RS00700	COG2376	Dihydroxyacetone kinase
B8X06_RS00705	COG1461	Dihydroxyacetone kinase
B8X06_RS00710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B8X06_RS00715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS00720	COG1609	Transcriptional regulator
B8X06_RS00725	COG1609	Transcriptional regulator
B8X06_RS00730	COG0366	Alpha amylase catalytic
B8X06_RS00735	COG2182	Extracellular solute-binding protein
B8X06_RS00740	COG1175	transmembrane transport
B8X06_RS00745	COG3833	ABC-type maltose transport systems, permease component
B8X06_RS00755	COG0366	Alpha amylase catalytic
B8X06_RS00760	COG3842	ATPase activity
B8X06_RS00810	COG1757	Na H antiporter
B8X06_RS00835	COG4166	transmembrane transport
B8X06_RS00840	COG4166	transmembrane transport
B8X06_RS00850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B8X06_RS00855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B8X06_RS00860	COG0406	alpha-ribazole phosphatase activity
B8X06_RS00865	COG0667	Aldo Keto reductase
B8X06_RS00895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B8X06_RS00900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B8X06_RS00905	COG0488	(ABC) transporter
B8X06_RS00915	COG4172	Belongs to the ABC transporter superfamily
B8X06_RS00925	COG0386	Belongs to the glutathione peroxidase family
B8X06_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B8X06_RS00950	COG0363	glucosamine-6-phosphate deaminase activity
B8X06_RS00960	COG2213	PTS system mannitol-specific
B8X06_RS00970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS00975	COG0246	Mannitol dehydrogenase
B8X06_RS00985	COG3118	belongs to the thioredoxin family
B8X06_RS01015	COG0431	NADPH-dependent FMN reductase
B8X06_RS01020	COG2188	Transcriptional regulator
B8X06_RS01025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS01040	COG3964	amidohydrolase
B8X06_RS01060	COG1045	serine acetyltransferase
B8X06_RS01065	COG0626	cystathionine gamma-synthase activity
B8X06_RS01070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B8X06_RS01100	COG2188	Transcriptional regulator
B8X06_RS01105	COG0366	Alpha amylase catalytic
B8X06_RS01110	COG2190	(PTS) system
B8X06_RS01110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS01110	COG1263	PTS System
B8X06_RS01115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS01115	COG1263	PTS System
B8X06_RS01115	COG2190	(PTS) system
B8X06_RS01125	COG0163	prenyltransferase activity
B8X06_RS01135	COG1959	2 iron, 2 sulfur cluster binding
B8X06_RS01140	COG1309	transcriptional regulator
B8X06_RS01145	COG1914	H( )-stimulated, divalent metal cation uptake system
B8X06_RS01165	COG2814	Major facilitator Superfamily
B8X06_RS01175	COG5002	protein histidine kinase activity
B8X06_RS01180	COG0745	RESPONSE REGULATOR receiver
B8X06_RS01190	COG1737	Transcriptional regulator
B8X06_RS01195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS01210	COG1316	TRANSCRIPTIONal
B8X06_RS01215	COG0277	FAD linked oxidase domain protein
B8X06_RS01225	COG2357	RelA SpoT domain protein
B8X06_RS01235	COG2409	Drug exporters of the RND superfamily
B8X06_RS01235	COG1033	growth of symbiont in host cell
B8X06_RS01240	COG2818	Glycosylase
B8X06_RS01250	COG0577	efflux transmembrane transporter activity
B8X06_RS01255	COG1136	(ABC) transporter
B8X06_RS01270	COG0741	lytic transglycosylase activity
B8X06_RS01275	COG1388	LysM domain
B8X06_RS01275	COG3942	CHAP domain
B8X06_RS01305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B8X06_RS01315	COG1846	Transcriptional regulator
B8X06_RS01320	COG1252	NADH dehydrogenase
B8X06_RS01360	COG3842	ATPase activity
B8X06_RS01390	COG1725	Transcriptional regulator
B8X06_RS01395	COG1131	(ABC) transporter
B8X06_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
B8X06_RS01405	COG1454	alcohol dehydrogenase
B8X06_RS01445	COG1268	BioY protein
B8X06_RS01460	COG0436	Aminotransferase
B8X06_RS01470	COG1682	transport, permease protein
B8X06_RS01475	COG1134	teichoic acid transport
B8X06_RS01490	COG2814	Major facilitator Superfamily
B8X06_RS01495	COG0004	ammonium transporteR
B8X06_RS01515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B8X06_RS01525	COG3759	membrane
B8X06_RS01530	COG1881	PFAM PEBP family protein
B8X06_RS01560	COG0300	oxidoreductase activity
B8X06_RS01580	COG1125	glycine betaine transport
B8X06_RS01590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B8X06_RS01600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS01665	COG0110	maltose O-acetyltransferase activity
B8X06_RS01675	COG0561	phosphatase activity
B8X06_RS01685	COG0561	phosphatase activity
B8X06_RS01690	COG1114	Component of the transport system for branched-chain amino acids
B8X06_RS01735	COG0463	Glycosyl transferase, family 2
B8X06_RS01760	COG3279	Response regulator of the LytR AlgR family
B8X06_RS01785	COG2274	protein secretion by the type I secretion system
B8X06_RS01820	COG3973	AAA domain
B8X06_RS01825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B8X06_RS01830	COG0180	Tryptophanyl-tRNA synthetase
B8X06_RS01835	COG2188	Transcriptional regulator
B8X06_RS01840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS01855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS01860	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS01865	COG1940	carbohydrate kinase activity
B8X06_RS01875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B8X06_RS01890	COG0248	Ppx GppA phosphatase
B8X06_RS01905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B8X06_RS01910	COG1801	Protein of unknown function DUF72
B8X06_RS01920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B8X06_RS01920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B8X06_RS01925	COG2814	Major facilitator Superfamily
B8X06_RS01930	COG0084	hydrolase, TatD family'
B8X06_RS01935	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B8X06_RS01940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B8X06_RS01945	COG4466	Protein conserved in bacteria
B8X06_RS01950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B8X06_RS01960	COG1073	alpha beta
B8X06_RS01965	COG1121	(ABC) transporter
B8X06_RS01970	COG1321	iron dependent repressor
B8X06_RS01970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B8X06_RS01990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B8X06_RS01995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B8X06_RS02005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B8X06_RS02025	COG1078	dGTPase activity
B8X06_RS02030	COG0095	Lipoate-protein ligase
B8X06_RS02040	COG3343	RNA polymerase activity
B8X06_RS02045	COG0504	CTP synthase activity
B8X06_RS02050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B8X06_RS02055	COG0814	amino acid
B8X06_RS02065	COG1760	l-serine dehydratase
B8X06_RS02070	COG1760	l-serine dehydratase
B8X06_RS02085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B8X06_RS02090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B8X06_RS02095	COG0254	rRNA binding
B8X06_RS02105	COG3764	Sortase (surface protein transpeptidase)
B8X06_RS02110	COG1704	LemA family
B8X06_RS02115	COG0501	Belongs to the peptidase M48B family
B8X06_RS02125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B8X06_RS02145	COG0736	holo-[acyl-carrier-protein] synthase activity
B8X06_RS02150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B8X06_RS02155	COG2337	Toxic component of a toxin-antitoxin (TA) module
B8X06_RS02160	COG3158	transport of potassium into the cell
B8X06_RS02180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B8X06_RS02185	COG0505	Belongs to the CarA family
B8X06_RS02190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B8X06_RS02195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B8X06_RS02200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B8X06_RS02205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B8X06_RS02210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B8X06_RS02225	COG2267	carboxylic ester hydrolase activity
B8X06_RS02240	COG0039	L-malate dehydrogenase activity
B8X06_RS02245	COG0193	aminoacyl-tRNA hydrolase activity
B8X06_RS02250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B8X06_RS02255	COG2244	polysaccharide biosynthetic process
B8X06_RS02260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B8X06_RS02270	COG1098	S1 RNA binding domain
B8X06_RS02275	COG0037	tRNA processing
B8X06_RS02290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B8X06_RS02295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B8X06_RS02300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B8X06_RS02340	COG3104	oligopeptide transport
B8X06_RS02390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B8X06_RS02400	COG2188	Transcriptional regulator
B8X06_RS02410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B8X06_RS02415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B8X06_RS02430	COG2183	response to ionizing radiation
B8X06_RS02435	COG3091	SprT-like family
B8X06_RS02440	COG0460	homoserine dehydrogenase
B8X06_RS02445	COG0083	homoserine kinase activity
B8X06_RS02460	COG3409	Peptidoglycan-binding domain 1 protein
B8X06_RS02485	COG3715	PTS system
B8X06_RS02490	COG3716	PTS system mannose fructose sorbose family IID component
B8X06_RS02500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B8X06_RS02500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B8X06_RS02505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS02505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS02510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS02510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS02515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B8X06_RS02525	COG0439	Biotin carboxylase
B8X06_RS02535	COG0825	malonyl-CoA metabolic process
B8X06_RS02540	COG1316	TRANSCRIPTIONal
B8X06_RS02550	COG0697	spore germination
B8X06_RS02555	COG0588	phosphoglycerate mutase activity
B8X06_RS02570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B8X06_RS02580	COG0756	dUTP diphosphatase activity
B8X06_RS02605	COG4956	integral membrane protein (PIN domain superfamily)
B8X06_RS02610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B8X06_RS02615	COG0215	cysteine-tRNA ligase activity
B8X06_RS02620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B8X06_RS02625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B8X06_RS02640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B8X06_RS02650	COG0250	Participates in transcription elongation, termination and antitermination
B8X06_RS02660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B8X06_RS02665	COG0081	regulation of translation
B8X06_RS02670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B8X06_RS02675	COG0222	ribosome binding
B8X06_RS02695	COG1611	Belongs to the LOG family
B8X06_RS02705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B8X06_RS02710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B8X06_RS02715	COG2813	Specifically methylates the guanine in position
B8X06_RS02730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B8X06_RS02735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B8X06_RS02740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B8X06_RS02750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B8X06_RS02755	COG3870	Protein conserved in bacteria
B8X06_RS02760	COG0470	DNA polymerase III
B8X06_RS02765	COG4467	Involved in initiation control of chromosome replication
B8X06_RS02780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B8X06_RS02785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B8X06_RS02790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B8X06_RS02795	COG3639	organic phosphonate transmembrane transporter activity
B8X06_RS02805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B8X06_RS02815	COG1214	PFAM Peptidase M22, glycoprotease
B8X06_RS02820	COG0456	acetyltransferase
B8X06_RS02825	COG0456	acetyltransferase
B8X06_RS02830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B8X06_RS02840	COG0488	(ABC) transporter
B8X06_RS02845	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B8X06_RS02855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B8X06_RS02860	COG0459	protein refolding
B8X06_RS02865	COG0531	amino acid
B8X06_RS02870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B8X06_RS02875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B8X06_RS02880	COG1739	Uncharacterized protein family UPF0029
B8X06_RS02885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B8X06_RS02900	COG0653	protein targeting
B8X06_RS02905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B8X06_RS02915	COG0745	RESPONSE REGULATOR receiver
B8X06_RS02920	COG5002	protein histidine kinase activity
B8X06_RS02925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B8X06_RS02930	COG0573	inorganic phosphate transmembrane transporter activity
B8X06_RS02935	COG0581	inorganic phosphate transmembrane transporter activity
B8X06_RS02940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B8X06_RS02945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B8X06_RS02950	COG0704	Plays a role in the regulation of phosphate uptake
B8X06_RS02955	COG1983	PspC domain protein
B8X06_RS02960	COG1950	PFAM Membrane protein of
B8X06_RS02965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B8X06_RS02970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B8X06_RS02975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B8X06_RS02980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B8X06_RS02990	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS03010	COG1215	transferase activity, transferring glycosyl groups
B8X06_RS03025	COG0492	ferredoxin-NADP+ reductase activity
B8X06_RS03030	COG2323	membrane
B8X06_RS03040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B8X06_RS03050	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS03060	COG2814	Major facilitator Superfamily
B8X06_RS03070	COG0556	nucleotide-excision repair
B8X06_RS03075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B8X06_RS03080	COG1854	S-ribosylhomocysteine lyase activity
B8X06_RS03085	COG0137	argininosuccinate synthase activity
B8X06_RS03090	COG0165	Argininosuccinate lyase
B8X06_RS03100	COG1660	Displays ATPase and GTPase activities
B8X06_RS03110	COG1481	regulation of sporulation
B8X06_RS03120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B8X06_RS03125	COG0740	serine-type endopeptidase activity
B8X06_RS03135	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B8X06_RS03140	COG2390	Transcriptional regulator
B8X06_RS03150	COG0126	phosphoglycerate kinase activity
B8X06_RS03155	COG0149	triose-phosphate isomerase activity
B8X06_RS03160	COG0148	phosphopyruvate hydratase activity
B8X06_RS03175	COG0038	chloride channel
B8X06_RS03180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B8X06_RS03190	COG0557	exoribonuclease II activity
B8X06_RS03195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B8X06_RS03205	COG0765	amino acid transport
B8X06_RS03210	COG1126	abc transporter atp-binding protein
B8X06_RS03220	COG0561	phosphatase activity
B8X06_RS03225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B8X06_RS03230	COG0280	phosphate acetyltransferase
B8X06_RS03235	COG0802	atpase or kinase
B8X06_RS03250	COG0708	Exodeoxyribonuclease III
B8X06_RS03260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B8X06_RS03265	COG0025	NhaP-type Na H and K H
B8X06_RS03290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B8X06_RS03295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B8X06_RS03305	COG0561	phosphatase activity
B8X06_RS03315	COG2017	converts alpha-aldose to the beta-anomer
B8X06_RS03335	COG0778	Nitroreductase
B8X06_RS03355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B8X06_RS03370	COG1393	Belongs to the ArsC family
B8X06_RS03395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B8X06_RS03405	COG3475	LICD family
B8X06_RS03420	COG2252	PERMEase
B8X06_RS03425	COG0028	Belongs to the TPP enzyme family
B8X06_RS03435	COG0028	Belongs to the TPP enzyme family
B8X06_RS03440	COG2267	carboxylic ester hydrolase activity
B8X06_RS03450	COG2755	lipolytic protein G-D-S-L family
B8X06_RS03450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B8X06_RS03455	COG2936	dipeptidyl-peptidase activity
B8X06_RS03470	COG0531	amino acid
B8X06_RS03495	COG0194	GDP metabolic process
B8X06_RS03500	COG0735	belongs to the Fur family
B8X06_RS03515	COG0546	phosphoglycolate phosphatase activity
B8X06_RS03520	COG0436	Aminotransferase
B8X06_RS03525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B8X06_RS03545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B8X06_RS03550	COG0765	amino acid transport
B8X06_RS03555	COG0765	amino acid transport
B8X06_RS03560	COG2190	(PTS) system
B8X06_RS03560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS03560	COG1263	PTS System
B8X06_RS03570	COG1263	PTS System
B8X06_RS03570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS03575	COG3394	polysaccharide catabolic process
B8X06_RS03580	COG0531	amino acid
B8X06_RS03590	COG1846	Transcriptional regulator
B8X06_RS03620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B8X06_RS03630	COG2076	Multidrug Resistance protein
B8X06_RS03645	COG0588	phosphoglycerate mutase activity
B8X06_RS03650	COG0569	domain protein
B8X06_RS03650	COG0475	glutathione-regulated potassium exporter activity
B8X06_RS03655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B8X06_RS03655	COG0456	acetyltransferase
B8X06_RS03660	COG3711	transcriptional antiterminator
B8X06_RS03665	COG1263	PTS System
B8X06_RS03665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS03665	COG2190	(PTS) system
B8X06_RS03670	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS03675	COG0586	Pfam SNARE associated Golgi protein
B8X06_RS03680	COG3973	AAA domain
B8X06_RS03685	COG2070	2-Nitropropane dioxygenase
B8X06_RS03690	COG1072	(Pantothenic acid kinase))
B8X06_RS03695	COG0519	Catalyzes the synthesis of GMP from XMP
B8X06_RS03695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B8X06_RS03705	COG4974	Belongs to the 'phage' integrase family
B8X06_RS03760	COG1396	sequence-specific DNA binding
B8X06_RS03770	COG1266	CAAX protease self-immunity
B8X06_RS03775	COG1733	regulation of RNA biosynthetic process
B8X06_RS03780	COG2814	Major facilitator Superfamily
B8X06_RS03825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B8X06_RS03825	COG2755	lipolytic protein G-D-S-L family
B8X06_RS03830	COG2261	transglycosylase associated protein
B8X06_RS03845	COG1302	Protein conserved in bacteria
B8X06_RS03875	COG0308	aminopeptidase N
B8X06_RS03880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B8X06_RS03935	COG0572	uridine kinase
B8X06_RS03950	COG0583	DNA-binding transcription factor activity
B8X06_RS03955	COG1053	succinate dehydrogenase
B8X06_RS03965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B8X06_RS03970	COG0017	Asparaginyl-tRNA synthetase
B8X06_RS03975	COG2502	aspartate--ammonia ligase
B8X06_RS03980	COG4690	dipeptidase activity
B8X06_RS04000	COG0514	ATP-dependent DNA helicase (RecQ)
B8X06_RS04005	COG0564	pseudouridine synthase activity
B8X06_RS04010	COG0640	Transcriptional regulator
B8X06_RS04060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B8X06_RS04065	COG0527	aspartate kinase activity
B8X06_RS04070	COG0367	asparagine synthase
B8X06_RS04120	COG2814	Major facilitator Superfamily
B8X06_RS04140	COG1278	Cold shock
B8X06_RS04145	COG2966	Psort location CytoplasmicMembrane, score
B8X06_RS04155	COG1316	TRANSCRIPTIONal
B8X06_RS04175	COG1959	2 iron, 2 sulfur cluster binding
B8X06_RS04180	COG0028	Belongs to the TPP enzyme family
B8X06_RS04185	COG0833	amino acid
B8X06_RS04195	COG1428	Deoxynucleoside kinase
B8X06_RS04200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B8X06_RS04240	COG4463	regulation of RNA biosynthetic process
B8X06_RS04255	COG0085	RNA polymerase activity
B8X06_RS04260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B8X06_RS04265	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B8X06_RS04270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B8X06_RS04275	COG0049	tRNA binding
B8X06_RS04280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B8X06_RS04285	COG0051	transcription antitermination factor activity, RNA binding
B8X06_RS04290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B8X06_RS04295	COG0088	Forms part of the polypeptide exit tunnel
B8X06_RS04300	COG0089	rRNA binding
B8X06_RS04305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B8X06_RS04310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B8X06_RS04315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B8X06_RS04320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B8X06_RS04325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B8X06_RS04330	COG0255	Belongs to the universal ribosomal protein uL29 family
B8X06_RS04335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B8X06_RS04340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B8X06_RS04345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B8X06_RS04350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B8X06_RS04355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B8X06_RS04360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B8X06_RS04365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B8X06_RS04370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B8X06_RS04375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B8X06_RS04380	COG1841	ribosomal large subunit assembly
B8X06_RS04385	COG0200	Binds to the 23S rRNA
B8X06_RS04395	COG0563	adenylate kinase activity
B8X06_RS04400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B8X06_RS04405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B8X06_RS04410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B8X06_RS04415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B8X06_RS04420	COG0202	RNA polymerase activity
B8X06_RS04425	COG0203	ribosomal protein L17
B8X06_RS04450	COG4939	FMN-binding domain protein
B8X06_RS04460	COG1122	ATPase activity
B8X06_RS04465	COG1122	ATPase activity
B8X06_RS04475	COG0101	tRNA pseudouridine synthase activity
B8X06_RS04480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B8X06_RS04485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B8X06_RS04505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B8X06_RS04510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B8X06_RS04515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B8X06_RS04520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B8X06_RS04525	COG0471	metal ion transport
B8X06_RS04530	COG2151	metal-sulfur cluster biosynthetic enzyme
B8X06_RS04535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B8X06_RS04545	COG1917	Cupin 2, conserved barrel domain protein
B8X06_RS04545	COG4977	sequence-specific DNA binding
B8X06_RS04550	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B8X06_RS04555	COG1121	(ABC) transporter
B8X06_RS04560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B8X06_RS04565	COG0803	Belongs to the bacterial solute-binding protein 9 family
B8X06_RS04575	COG0039	L-malate dehydrogenase activity
B8X06_RS04580	COG0471	metal ion transport
B8X06_RS04600	COG3052	prosthetic group binding
B8X06_RS04620	COG0114	fumarate hydratase activity
B8X06_RS04625	COG1053	succinate dehydrogenase
B8X06_RS04635	COG0583	DNA-binding transcription factor activity
B8X06_RS04645	COG0583	DNA-binding transcription factor activity
B8X06_RS04650	COG0281	malic enzyme
B8X06_RS04660	COG0531	amino acid
B8X06_RS04665	COG4684	Psort location CytoplasmicMembrane, score
B8X06_RS04680	COG1271	oxidase subunit
B8X06_RS04685	COG1294	oxidase, subunit
B8X06_RS04690	COG4988	ABC transporter
B8X06_RS04695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B8X06_RS04710	COG0142	geranyltranstransferase activity
B8X06_RS04725	COG1705	Flagellar rod assembly protein muramidase FlgJ
B8X06_RS04730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B8X06_RS04735	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B8X06_RS04740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B8X06_RS04750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B8X06_RS04755	COG4851	CamS sex pheromone cAM373 precursor
B8X06_RS04760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B8X06_RS04765	COG0154	amidase activity
B8X06_RS04770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B8X06_RS04775	COG1597	lipid kinase activity
B8X06_RS04780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B8X06_RS04795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS04805	COG1737	Transcriptional regulator
B8X06_RS04820	COG1278	Cold shock
B8X06_RS04825	COG0673	inositol 2-dehydrogenase activity
B8X06_RS04830	COG0513	Belongs to the DEAD box helicase family
B8X06_RS04845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS04870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B8X06_RS04880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B8X06_RS04890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS04895	COG0562	UDP-galactopyranose mutase
B8X06_RS04940	COG2244	polysaccharide biosynthetic process
B8X06_RS04945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B8X06_RS04955	COG1088	dTDP-glucose 4,6-dehydratase activity
B8X06_RS04960	COG0582	viral genome integration into host DNA
B8X06_RS04970	COG0489	protein tyrosine kinase activity
B8X06_RS04975	COG4464	protein tyrosine phosphatase activity
B8X06_RS04985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B8X06_RS04995	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS05010	COG5039	Polysaccharide pyruvyl transferase
B8X06_RS05110	COG0562	UDP-galactopyranose mutase
B8X06_RS05145	COG2207	Transcriptional regulator
B8X06_RS05145	COG1609	Transcriptional regulator
B8X06_RS05165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B8X06_RS05200	COG2137	regulation of response to DNA damage stimulus
B8X06_RS05205	COG3557	Belongs to the UPF0374 family
B8X06_RS05225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B8X06_RS05235	COG0628	permease
B8X06_RS05240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B8X06_RS05245	COG2610	gluconate transmembrane transporter activity
B8X06_RS05250	COG1070	Carbohydrate kinase
B8X06_RS05255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B8X06_RS05260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B8X06_RS05265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B8X06_RS05295	COG4166	transmembrane transport
B8X06_RS05300	COG0601	transmembrane transport
B8X06_RS05305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B8X06_RS05310	COG0444	Belongs to the ABC transporter superfamily
B8X06_RS05315	COG4608	Belongs to the ABC transporter superfamily
B8X06_RS05325	COG0582	viral genome integration into host DNA
B8X06_RS05330	COG0542	response to heat
B8X06_RS05350	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS05355	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS05365	COG1686	Belongs to the peptidase S11 family
B8X06_RS05370	COG0436	Aminotransferase
B8X06_RS05375	COG4703	Protein of unknown function (DUF1797)
B8X06_RS05380	COG1368	sulfuric ester hydrolase activity
B8X06_RS05470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B8X06_RS05490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B8X06_RS05505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B8X06_RS05510	COG0833	amino acid
B8X06_RS05515	COG2040	homocysteine
B8X06_RS05520	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS05530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B8X06_RS05535	COG0477	Major facilitator Superfamily
B8X06_RS05550	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS05565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B8X06_RS05575	COG0495	leucyl-tRNA aminoacylation
B8X06_RS05580	COG2244	polysaccharide biosynthetic process
B8X06_RS05585	COG1187	pseudouridine synthase activity
B8X06_RS05590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B8X06_RS05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B8X06_RS05605	COG3842	ATPase activity
B8X06_RS05610	COG1175	transmembrane transport
B8X06_RS05615	COG0395	ABC-type sugar transport system, permease component
B8X06_RS05625	COG0584	glycerophosphoryl diester phosphodiesterase
B8X06_RS05630	COG1428	Deoxynucleoside kinase
B8X06_RS05635	COG1970	mechanosensitive ion channel activity
B8X06_RS05640	COG1511	domain protein
B8X06_RS05640	COG1511	domain protein
B8X06_RS05670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B8X06_RS05675	COG0789	Transcriptional regulator
B8X06_RS05685	COG0697	spore germination
B8X06_RS05690	COG0561	phosphatase activity
B8X06_RS05710	COG3279	Response regulator of the LytR AlgR family
B8X06_RS05745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B8X06_RS05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B8X06_RS05785	COG0646	methionine synthase
B8X06_RS05790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B8X06_RS05800	COG2046	Belongs to the sulfate adenylyltransferase family
B8X06_RS05805	COG0529	Catalyzes the synthesis of activated sulfate
B8X06_RS05810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B8X06_RS05820	COG3273	potassium ion transport
B8X06_RS05820	COG0471	metal ion transport
B8X06_RS05825	COG0534	Mate efflux family protein
B8X06_RS05845	COG2153	protein acetylation
B8X06_RS05850	COG0018	arginyl-trna synthetase
B8X06_RS05860	COG1136	(ABC) transporter
B8X06_RS05860	COG0577	efflux transmembrane transporter activity
B8X06_RS05880	COG1447	Phosphotransferase system cellobiose-specific component IIA
B8X06_RS05885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS05890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS05895	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS05905	COG1376	ErfK ybiS ycfS ynhG family protein
B8X06_RS05910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B8X06_RS05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B8X06_RS05925	COG0436	Aminotransferase
B8X06_RS05930	COG1438	arginine binding
B8X06_RS05940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B8X06_RS05945	COG3679	Belongs to the UPF0342 family
B8X06_RS05950	COG0420	3'-5' exonuclease activity
B8X06_RS05955	COG4717	serine-type aminopeptidase activity
B8X06_RS05960	COG3481	metal-dependent phosphohydrolase, HD sub domain
B8X06_RS05975	COG0583	DNA-binding transcription factor activity
B8X06_RS05990	COG1053	succinate dehydrogenase
B8X06_RS05990	COG3976	FMN-binding domain protein
B8X06_RS05990	COG0431	NADPH-dependent FMN reductase
B8X06_RS06005	COG3850	Histidine kinase
B8X06_RS06005	COG5002	protein histidine kinase activity
B8X06_RS06010	COG0745	RESPONSE REGULATOR receiver
B8X06_RS06020	COG0463	Glycosyl transferase, family 2
B8X06_RS06025	COG0586	Pfam SNARE associated Golgi protein
B8X06_RS06030	COG0463	Glycosyl transferase, family 2
B8X06_RS06050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B8X06_RS06050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B8X06_RS06055	COG0307	riboflavin synthase, alpha
B8X06_RS06060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B8X06_RS06060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B8X06_RS06065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B8X06_RS06080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B8X06_RS06090	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS06120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B8X06_RS06130	COG0537	adenosine 5'-monophosphoramidase activity
B8X06_RS06135	COG1131	(ABC) transporter
B8X06_RS06140	COG4473	ABC transporter
B8X06_RS06145	COG0510	thiamine kinase activity
B8X06_RS06150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B8X06_RS06160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B8X06_RS06165	COG1674	ftsk spoiiie
B8X06_RS06170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B8X06_RS06195	COG0719	Fe-S assembly protein
B8X06_RS06200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B8X06_RS06210	COG0719	Fe-S assembly protein
B8X06_RS06215	COG2151	metal-sulfur cluster biosynthetic enzyme
B8X06_RS06230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B8X06_RS06230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B8X06_RS06235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B8X06_RS06240	COG0237	dephospho-CoA kinase activity
B8X06_RS06245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B8X06_RS06250	COG3611	Membrane attachment protein
B8X06_RS06255	COG1484	DNA-dependent DNA replication
B8X06_RS06260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B8X06_RS06265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B8X06_RS06270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B8X06_RS06275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B8X06_RS06285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B8X06_RS06295	COG1733	regulation of RNA biosynthetic process
B8X06_RS06305	COG1215	transferase activity, transferring glycosyl groups
B8X06_RS06320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B8X06_RS06325	COG1534	Rna-binding protein
B8X06_RS06330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B8X06_RS06335	COG1713	HD superfamily hydrolase involved in NAD metabolism
B8X06_RS06340	COG0799	negative regulation of ribosome biogenesis
B8X06_RS06345	COG2226	methyltransferase
B8X06_RS06350	COG1323	Belongs to the UPF0348 family
B8X06_RS06360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B8X06_RS06375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B8X06_RS06385	COG0745	RESPONSE REGULATOR receiver
B8X06_RS06390	COG5002	protein histidine kinase activity
B8X06_RS06400	COG0419	ATPase involved in DNA repair
B8X06_RS06415	COG0706	membrane insertase activity
B8X06_RS06420	COG1254	Belongs to the acylphosphatase family
B8X06_RS06425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B8X06_RS06435	COG1733	regulation of RNA biosynthetic process
B8X06_RS06440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B8X06_RS06445	COG0072	phenylalanine-tRNA ligase activity
B8X06_RS06445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B8X06_RS06450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B8X06_RS06455	COG0572	uridine kinase
B8X06_RS06460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B8X06_RS06480	COG4841	protein insertion into membrane
B8X06_RS06490	COG0768	penicillin binding
B8X06_RS06495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B8X06_RS06500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B8X06_RS06505	COG0705	Rhomboid family
B8X06_RS06505	COG0457	Tetratricopeptide repeat
B8X06_RS06515	COG1940	carbohydrate kinase activity
B8X06_RS06535	COG0584	glycerophosphoryl diester phosphodiesterase
B8X06_RS06540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B8X06_RS06545	COG0789	Transcriptional regulator
B8X06_RS06595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B8X06_RS06605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B8X06_RS06610	COG0006	proline dipeptidase activity
B8X06_RS06615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B8X06_RS06620	COG1302	Protein conserved in bacteria
B8X06_RS06625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B8X06_RS06630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B8X06_RS06635	COG1570	exodeoxyribonuclease VII activity
B8X06_RS06640	COG1722	exodeoxyribonuclease VII activity
B8X06_RS06645	COG0142	geranyltranstransferase activity
B8X06_RS06650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B8X06_RS06655	COG1438	arginine binding
B8X06_RS06660	COG0497	DNA recombination
B8X06_RS06675	COG1732	Glycine betaine
B8X06_RS06690	COG0194	GDP metabolic process
B8X06_RS06695	COG1758	RNA polymerase activity
B8X06_RS06700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B8X06_RS06705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B8X06_RS06710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B8X06_RS06715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B8X06_RS06715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B8X06_RS06720	COG0631	protein serine/threonine phosphatase activity
B8X06_RS06725	COG0515	serine threonine protein kinase
B8X06_RS06725	COG2815	serine threonine protein kinase
B8X06_RS06730	COG1162	GTPase activity
B8X06_RS06735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B8X06_RS06740	COG1564	THIamine pyrophosphokinase
B8X06_RS06745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B8X06_RS06750	COG1302	Protein conserved in bacteria
B8X06_RS06755	COG1461	Dihydroxyacetone kinase
B8X06_RS06760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B8X06_RS06765	COG0416	fatty acid biosynthetic process
B8X06_RS06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B8X06_RS06775	COG0571	ribonuclease III activity
B8X06_RS06780	COG1196	nuclear chromosome segregation
B8X06_RS06785	COG0552	protein localization to endoplasmic reticulum
B8X06_RS06790	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B8X06_RS06795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B8X06_RS06800	COG0228	four-way junction DNA binding
B8X06_RS06805	COG1837	Belongs to the UPF0109 family
B8X06_RS06810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B8X06_RS06815	COG0336	Belongs to the RNA methyltransferase TrmD family
B8X06_RS06820	COG0335	large ribosomal subunit rRNA binding
B8X06_RS06840	COG1131	(ABC) transporter
B8X06_RS06855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B8X06_RS06855	COG0512	Glutamine amidotransferase of anthranilate synthase
B8X06_RS06860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B8X06_RS06865	COG0134	indole-3-glycerol-phosphate synthase activity
B8X06_RS06870	COG0135	phosphoribosylanthranilate isomerase activity
B8X06_RS06875	COG0133	tryptophan synthase activity
B8X06_RS06880	COG0159	tryptophan synthase activity
B8X06_RS06895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B8X06_RS06905	COG1473	amidohydrolase
B8X06_RS06910	COG1063	alcohol dehydrogenase
B8X06_RS06920	COG0300	oxidoreductase activity
B8X06_RS06930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B8X06_RS06935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B8X06_RS06940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B8X06_RS06945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B8X06_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS06955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B8X06_RS06970	COG0439	Biotin carboxylase
B8X06_RS06985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B8X06_RS06995	COG1811	Na channel or pump
B8X06_RS07000	COG0583	DNA-binding transcription factor activity
B8X06_RS07005	COG1607	acyl-coa hydrolase
B8X06_RS07010	COG1162	GTPase activity
B8X06_RS07020	COG0477	Major facilitator Superfamily
B8X06_RS07070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B8X06_RS07075	COG3397	chitin binding
B8X06_RS07090	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B8X06_RS07100	COG3152	Membrane
B8X06_RS07105	COG1597	lipid kinase activity
B8X06_RS07120	COG2261	transglycosylase associated protein
B8X06_RS07125	COG3237	CsbD-like
B8X06_RS07140	COG1942	4-Oxalocrotonate Tautomerase
B8X06_RS07180	COG0531	amino acid
B8X06_RS07185	COG0561	phosphatase activity
B8X06_RS07190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B8X06_RS07190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B8X06_RS07210	COG2017	converts alpha-aldose to the beta-anomer
B8X06_RS07215	COG1304	FMN binding
B8X06_RS07240	COG1199	ATP-dependent helicase activity
B8X06_RS07240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B8X06_RS07255	COG0017	Asparaginyl-tRNA synthetase
B8X06_RS07270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B8X06_RS07275	COG2011	ABC-type metal ion transport system permease component
B8X06_RS07280	COG1464	Belongs to the NlpA lipoprotein family
B8X06_RS07290	COG1177	transmembrane transport
B8X06_RS07295	COG1840	ABC-type Fe3 transport system, periplasmic component
B8X06_RS07310	COG3331	DNA recombination
B8X06_RS07315	COG4474	Belongs to the UPF0398 family
B8X06_RS07320	COG3599	regulation of cell shape
B8X06_RS07330	COG0116	Belongs to the methyltransferase superfamily
B8X06_RS07335	COG1073	alpha beta
B8X06_RS07345	COG1216	Glycosyl transferase, family 2
B8X06_RS07365	COG1619	proteins homologs of microcin C7 resistance protein MccF
B8X06_RS07390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B8X06_RS07405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B8X06_RS07410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B8X06_RS07415	COG0564	pseudouridine synthase activity
B8X06_RS07420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B8X06_RS07425	COG0505	Belongs to the CarA family
B8X06_RS07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B8X06_RS07445	COG5646	InterPro IPR014922
B8X06_RS07470	COG1131	(ABC) transporter
B8X06_RS07475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B8X06_RS07480	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B8X06_RS07490	COG1307	EDD domain protein, DegV family
B8X06_RS07550	COG1113	amino acid transport
B8X06_RS07570	COG1620	l-lactate permease
B8X06_RS07580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B8X06_RS07605	COG1846	Transcriptional regulator
B8X06_RS07610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B8X06_RS07645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B8X06_RS07650	COG1227	inorganic diphosphatase activity
B8X06_RS07655	COG0583	DNA-binding transcription factor activity
B8X06_RS07665	COG0187	DNA topoisomerase II activity
B8X06_RS07670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B8X06_RS07680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B8X06_RS07685	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B8X06_RS07690	COG4974	Belongs to the 'phage' integrase family
B8X06_RS07695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B8X06_RS07700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B8X06_RS07705	COG0758	DNA mediated transformation
B8X06_RS07710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B8X06_RS07715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B8X06_RS07725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B8X06_RS07730	COG0583	DNA-binding transcription factor activity
B8X06_RS07745	COG2814	Major facilitator Superfamily
B8X06_RS07755	COG3409	Peptidoglycan-binding domain 1 protein
B8X06_RS07755	COG0793	Belongs to the peptidase S41A family
B8X06_RS07760	COG4479	Belongs to the UPF0346 family
B8X06_RS07765	COG4698	Protein conserved in bacteria
B8X06_RS07770	COG2755	lipolytic protein G-D-S-L family
B8X06_RS07775	COG1307	EDD domain protein, DegV family
B8X06_RS07780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B8X06_RS07785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B8X06_RS07790	COG0488	(ABC) transporter
B8X06_RS07800	COG0617	tRNA 3'-terminal CCA addition
B8X06_RS07805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B8X06_RS07810	COG0561	phosphatase activity
B8X06_RS07815	COG0457	Tetratricopeptide repeat
B8X06_RS07830	COG1160	GTP binding
B8X06_RS07835	COG0539	negative regulation of cytoplasmic translation
B8X06_RS07840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B8X06_RS07850	COG0514	ATP-dependent DNA helicase (RecQ)
B8X06_RS07860	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B8X06_RS07865	COG1187	pseudouridine synthase activity
B8X06_RS07870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B8X06_RS07875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B8X06_RS07885	COG4974	Belongs to the 'phage' integrase family
B8X06_RS07890	COG2996	Protein conserved in bacteria
B8X06_RS07910	COG0205	6-phosphofructokinase activity
B8X06_RS07915	COG0587	DNA-directed DNA polymerase activity
B8X06_RS07925	COG0542	response to heat
B8X06_RS07935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B8X06_RS07940	COG2384	SAM-dependent methyltransferase
B8X06_RS07965	COG0574	Belongs to the PEP-utilizing enzyme family
B8X06_RS07965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B8X06_RS07975	COG1846	Transcriptional regulator
B8X06_RS07995	COG2217	Heavy metal translocating P-type atpase
B8X06_RS08000	COG0148	phosphopyruvate hydratase activity
B8X06_RS08005	COG0477	Major facilitator Superfamily
B8X06_RS08015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B8X06_RS08020	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS08025	COG1349	DNA-binding transcription factor activity
B8X06_RS08035	COG1393	Belongs to the ArsC family
B8X06_RS08055	COG0546	phosphoglycolate phosphatase activity
B8X06_RS08085	COG0583	DNA-binding transcription factor activity
B8X06_RS08090	COG0604	alcohol dehydrogenase
B8X06_RS08100	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS08105	COG2197	response regulator
B8X06_RS08110	COG4585	Histidine kinase
B8X06_RS08120	COG1131	(ABC) transporter
B8X06_RS08130	COG0519	Catalyzes the synthesis of GMP from XMP
B8X06_RS08145	COG1131	(ABC) transporter
B8X06_RS08165	COG1131	(ABC) transporter
B8X06_RS08170	COG1725	Transcriptional regulator
B8X06_RS08180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B8X06_RS08185	COG0358	DNA primase activity
B8X06_RS08190	COG0751	glycine-tRNA ligase activity
B8X06_RS08195	COG0752	glycyl-tRNA synthetase alpha subunit
B8X06_RS08200	COG1381	Involved in DNA repair and RecF pathway recombination
B8X06_RS08205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B8X06_RS08210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B8X06_RS08215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B8X06_RS08220	COG1702	phosphate starvation-inducible protein PhoH
B8X06_RS08225	COG1610	YqeY-like protein
B8X06_RS08230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B8X06_RS08235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B8X06_RS08245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B8X06_RS08255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B8X06_RS08265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B8X06_RS08270	COG0124	histidyl-tRNA synthetase
B8X06_RS08275	COG0860	N-Acetylmuramoyl-L-alanine amidase
B8X06_RS08275	COG3103	Sh3 type 3 domain protein
B8X06_RS08275	COG4991	sh3 domain protein
B8X06_RS08280	COG3001	Fructosamine kinase
B8X06_RS08285	COG0546	phosphoglycolate phosphatase activity
B8X06_RS08290	COG1490	D-aminoacyl-tRNA deacylase activity
B8X06_RS08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B8X06_RS08305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B8X06_RS08310	COG2264	protein methyltransferase activity
B8X06_RS08315	COG2094	Belongs to the DNA glycosylase MPG family
B8X06_RS08330	COG0481	GTPase activity
B8X06_RS08335	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B8X06_RS08340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B8X06_RS08345	COG1696	Membrane protein involved in D-alanine export
B8X06_RS08350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B8X06_RS08360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B8X06_RS08365	COG0484	heat shock protein binding
B8X06_RS08370	COG0443	Heat shock 70 kDa protein
B8X06_RS08375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B8X06_RS08380	COG1420	regulation of RNA biosynthetic process
B8X06_RS08385	COG3527	Alpha-acetolactate decarboxylase
B8X06_RS08390	COG0196	riboflavin kinase activity
B8X06_RS08395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B8X06_RS08400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B8X06_RS08405	COG0287	Prephenate dehydrogenase
B8X06_RS08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B8X06_RS08420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B8X06_RS08425	COG0738	Major facilitator superfamily
B8X06_RS08430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B8X06_RS08435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B8X06_RS08445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B8X06_RS08450	COG0195	Participates in both transcription termination and antitermination
B8X06_RS08455	COG0779	Required for maturation of 30S ribosomal subunits
B8X06_RS08460	COG2176	DNA-directed DNA polymerase activity
B8X06_RS08465	COG0442	prolyl-tRNA aminoacylation
B8X06_RS08470	COG0750	zinc metalloprotease
B8X06_RS08475	COG4589	Belongs to the CDS family
B8X06_RS08480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B8X06_RS08485	COG0233	cytoplasmic translational termination
B8X06_RS08490	COG0528	UMP kinase activity
B8X06_RS08495	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B8X06_RS08500	COG0052	Belongs to the universal ribosomal protein uS2 family
B8X06_RS08510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B8X06_RS08515	COG2827	Endonuclease containing a URI domain
B8X06_RS08520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B8X06_RS08525	COG0204	Acyl-transferase
B8X06_RS08530	COG3763	UPF0154 protein
B8X06_RS08535	COG4224	UPF0291 protein
B8X06_RS08540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B8X06_RS08555	COG3425	synthase
B8X06_RS08570	COG0463	Glycosyl transferase, family 2
B8X06_RS08580	COG1316	TRANSCRIPTIONal
B8X06_RS08585	COG1116	anion transmembrane transporter activity
B8X06_RS08595	COG0772	Belongs to the SEDS family
B8X06_RS08810	COG1396	sequence-specific DNA binding
B8X06_RS09000	COG1396	sequence-specific DNA binding
B8X06_RS09075	COG0393	Putative heavy-metal-binding
B8X06_RS09090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B8X06_RS09095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B8X06_RS09095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B8X06_RS09100	COG5416	Lipopolysaccharide assembly protein A domain
B8X06_RS09105	COG0300	oxidoreductase activity
B8X06_RS09110	COG1234	tRNA 3'-trailer cleavage
B8X06_RS09120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B8X06_RS09125	COG1349	DNA-binding transcription factor activity
B8X06_RS09130	COG1105	Belongs to the carbohydrate kinase PfkB family
B8X06_RS09135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS09135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS09135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS09140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B8X06_RS09165	COG0297	glycogen (starch) synthase activity
B8X06_RS09170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B8X06_RS09175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B8X06_RS09185	COG0489	protein tyrosine kinase activity
B8X06_RS09195	COG0322	excinuclease ABC activity
B8X06_RS09200	COG1126	abc transporter atp-binding protein
B8X06_RS09205	COG0765	amino acid transport
B8X06_RS09225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B8X06_RS09230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B8X06_RS09235	COG0544	peptidyl-prolyl cis-trans isomerase activity
B8X06_RS09240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B8X06_RS09265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B8X06_RS09270	COG0268	Binds directly to 16S ribosomal RNA
B8X06_RS09275	COG1466	dna polymerase III delta subunit
B8X06_RS09280	COG2333	competence protein COMEC
B8X06_RS09280	COG0658	competence protein
B8X06_RS09285	COG2131	deaminase
B8X06_RS09290	COG1596	polysaccharide export
B8X06_RS09290	COG1555	photosystem II stabilization
B8X06_RS09295	COG3480	Lon protease (S16) C-terminal proteolytic domain
B8X06_RS09300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B8X06_RS09305	COG0742	ribosomal rna small subunit methyltransferase
B8X06_RS09310	COG4471	UPF0298 protein
B8X06_RS09315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B8X06_RS09320	COG0772	Belongs to the SEDS family
B8X06_RS09355	COG1217	gtp-binding protein TYPA
B8X06_RS09360	COG0483	inositol monophosphate 1-phosphatase activity
B8X06_RS09365	COG4476	Belongs to the UPF0223 family
B8X06_RS09370	COG0039	L-malate dehydrogenase activity
B8X06_RS09395	COG0242	peptide deformylase activity
B8X06_RS09405	COG5503	Protein of unknown function (DUF1447)
B8X06_RS09410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B8X06_RS09415	COG1597	lipid kinase activity
B8X06_RS09425	COG1388	LysM domain
B8X06_RS09425	COG3584	3D domain protein
B8X06_RS09430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B8X06_RS09435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B8X06_RS09470	COG0569	domain protein
B8X06_RS09475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B8X06_RS09480	COG0482	sulfurtransferase activity
B8X06_RS09490	COG1104	cysteine desulfurase activity
B8X06_RS09495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B8X06_RS09505	COG0494	nUDIX hydrolase
B8X06_RS09510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B8X06_RS09520	COG3279	Response regulator of the LytR AlgR family
B8X06_RS09535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B8X06_RS09540	COG3599	regulation of cell shape
B8X06_RS09550	COG0762	integral membrane protein
B8X06_RS09555	COG1799	cell septum assembly
B8X06_RS09570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B8X06_RS09575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B8X06_RS09580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B8X06_RS09585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B8X06_RS09590	COG0768	penicillin binding
B8X06_RS09600	COG0275	rRNA processing
B8X06_RS09605	COG2001	Belongs to the MraZ family
B8X06_RS09630	COG1674	ftsk spoiiie
B8X06_RS09635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B8X06_RS09645	COG1114	Component of the transport system for branched-chain amino acids
B8X06_RS09660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B8X06_RS09665	COG0628	permease
B8X06_RS09675	COG2706	6-phosphogluconolactonase activity
B8X06_RS09680	COG3142	Participates in the control of copper homeostasis
B8X06_RS09685	COG0564	pseudouridine synthase activity
B8X06_RS09690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B8X06_RS09695	COG2357	RelA SpoT domain protein
B8X06_RS09705	COG1164	Oligoendopeptidase f
B8X06_RS09715	COG4862	establishment of competence for transformation
B8X06_RS09720	COG1393	Belongs to the ArsC family
B8X06_RS09725	COG1234	tRNA 3'-trailer cleavage
B8X06_RS09870	COG1098	S1 RNA binding domain
B8X06_RS09880	COG0586	Pfam SNARE associated Golgi protein
B8X06_RS09890	COG0647	UMP catabolic process
B8X06_RS09895	COG4470	Protein conserved in bacteria
B8X06_RS09900	COG0737	Belongs to the 5'-nucleotidase family
B8X06_RS09915	COG1113	amino acid transport
B8X06_RS09920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B8X06_RS09925	COG0827	DNA restriction-modification system
B8X06_RS09955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B8X06_RS09965	COG0217	transcriptional regulatory protein
B8X06_RS09980	COG1609	Transcriptional regulator
B8X06_RS09985	COG0006	proline dipeptidase activity
B8X06_RS09990	COG0789	Transcriptional regulator
B8X06_RS10005	COG0668	transmembrane transport
B8X06_RS10010	COG1473	amidohydrolase
B8X06_RS10015	COG2171	N-acyltransferase activity
B8X06_RS10020	COG0517	IMP dehydrogenase activity
B8X06_RS10030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B8X06_RS10035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B8X06_RS10040	COG1719	4-vinyl reductase, 4VR
B8X06_RS10045	COG3118	belongs to the thioredoxin family
B8X06_RS10050	COG1193	negative regulation of DNA recombination
B8X06_RS10060	COG3906	Belongs to the UPF0473 family
B8X06_RS10065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B8X06_RS10070	COG4472	Bacterial protein of unknown function (DUF965)
B8X06_RS10075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B8X06_RS10080	COG0513	Belongs to the DEAD box helicase family
B8X06_RS10085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B8X06_RS10090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B8X06_RS10095	COG1862	Preprotein translocase
B8X06_RS10100	COG0343	queuine tRNA-ribosyltransferase activity
B8X06_RS10105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B8X06_RS10110	COG2255	four-way junction helicase activity
B8X06_RS10115	COG0632	four-way junction helicase activity
B8X06_RS10145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B8X06_RS10150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B8X06_RS10155	COG1692	metallophosphoesterase
B8X06_RS10160	COG1418	mRNA catabolic process
B8X06_RS10165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B8X06_RS10170	COG1058	Belongs to the CinA family
B8X06_RS10170	COG1546	Belongs to the CinA family
B8X06_RS10175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B8X06_RS10180	COG1426	Protein conserved in bacteria
B8X06_RS10185	COG0612	Peptidase, M16
B8X06_RS10190	COG0612	Peptidase, M16
B8X06_RS10195	COG0527	aspartate kinase activity
B8X06_RS10205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B8X06_RS10210	COG1126	abc transporter atp-binding protein
B8X06_RS10215	COG0765	amino acid transport
B8X06_RS10220	COG2894	cell division
B8X06_RS10225	COG0850	regulation of cytokinetic process
B8X06_RS10235	COG1792	Involved in formation and maintenance of cell shape
B8X06_RS10240	COG1077	Cell shape determining protein MreB Mrl
B8X06_RS10245	COG2003	Belongs to the UPF0758 family
B8X06_RS10250	COG0285	dihydrofolate synthase activity
B8X06_RS10255	COG0525	valine-tRNA ligase activity
B8X06_RS10265	COG1181	Belongs to the D-alanine--D-alanine ligase family
B8X06_RS10265	COG2918	glutathione biosynthetic process
B8X06_RS10275	COG0301	tRNA thio-modification
B8X06_RS10280	COG1104	cysteine desulfurase activity
B8X06_RS10290	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B8X06_RS10295	COG1956	GAF domain-containing protein
B8X06_RS10300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B8X06_RS10305	COG4493	Belongs to the UPF0637 family
B8X06_RS10320	COG0640	Transcriptional regulator
B8X06_RS10325	COG0366	Alpha amylase catalytic
B8X06_RS10335	COG3716	PTS system mannose fructose sorbose family IID component
B8X06_RS10340	COG3715	PTS system
B8X06_RS10345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS10350	COG1609	Transcriptional regulator
B8X06_RS10355	COG2918	glutathione biosynthetic process
B8X06_RS10355	COG0189	ligase activity
B8X06_RS10360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B8X06_RS10375	COG0589	response to stress
B8X06_RS10395	COG1181	Belongs to the D-alanine--D-alanine ligase family
B8X06_RS10415	COG1464	Belongs to the NlpA lipoprotein family
B8X06_RS10420	COG2011	ABC-type metal ion transport system permease component
B8X06_RS10425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B8X06_RS10430	COG0509	glycine decarboxylation via glycine cleavage system
B8X06_RS10435	COG0772	Belongs to the SEDS family
B8X06_RS10445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B8X06_RS10450	COG1077	Cell shape determining protein MreB Mrl
B8X06_RS10460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B8X06_RS10465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B8X06_RS10470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B8X06_RS10475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B8X06_RS10480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B8X06_RS10485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B8X06_RS10490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B8X06_RS10495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B8X06_RS10500	COG0356	it plays a direct role in the translocation of protons across the membrane
B8X06_RS10505	COG2233	PERMEase
B8X06_RS10515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B8X06_RS10520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B8X06_RS10525	COG0009	L-threonylcarbamoyladenylate synthase
B8X06_RS10530	COG2890	protein-(glutamine-N5) methyltransferase activity
B8X06_RS10535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B8X06_RS10540	COG1435	thymidine kinase activity
B8X06_RS10545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B8X06_RS10550	COG3442	glutamine amidotransferase
B8X06_RS10555	COG1482	cell wall glycoprotein biosynthetic process
B8X06_RS10560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B8X06_RS10570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B8X06_RS10585	COG1132	(ABC) transporter
B8X06_RS10600	COG0726	polysaccharide deacetylase
B8X06_RS10740	COG2868	ribosomal protein
B8X06_RS10950	COG4932	domain protein
B8X06_RS10950	COG4886	Leucine-rich repeat (LRR) protein
B8X06_RS11000	COG1132	(ABC) transporter
B8X06_RS11010	COG0577	efflux transmembrane transporter activity
B8X06_RS11010	COG1136	(ABC) transporter
B8X06_RS11020	COG0166	Belongs to the GPI family
B8X06_RS11025	COG4975	Glucose uptake
B8X06_RS11030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B8X06_RS11035	COG5002	protein histidine kinase activity
B8X06_RS11035	COG3850	Histidine kinase
B8X06_RS11040	COG0745	RESPONSE REGULATOR receiver
B8X06_RS11045	COG2848	UPF0210 protein
B8X06_RS11050	COG3830	Belongs to the UPF0237 family
B8X06_RS11075	COG0477	Major facilitator Superfamily
B8X06_RS11095	COG0791	NLP P60 protein
B8X06_RS11100	COG1522	sequence-specific DNA binding
B8X06_RS11120	COG0488	(ABC) transporter
B8X06_RS11150	COG2190	(PTS) system
B8X06_RS11150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS11150	COG1263	PTS System
B8X06_RS11155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B8X06_RS11160	COG1307	EDD domain protein, DegV family
B8X06_RS11170	COG2873	o-acetylhomoserine
B8X06_RS11175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B8X06_RS11190	COG4120	Belongs to the binding-protein-dependent transport system permease family
B8X06_RS11200	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS11215	COG2084	Dehydrogenase
B8X06_RS11220	COG0861	Integral membrane protein TerC family
B8X06_RS11225	COG0110	maltose O-acetyltransferase activity
B8X06_RS11230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B8X06_RS11235	COG0140	phosphoribosyl-ATP diphosphatase activity
B8X06_RS11240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B8X06_RS11245	COG0107	imidazoleglycerol-phosphate synthase activity
B8X06_RS11250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B8X06_RS11255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B8X06_RS11260	COG0131	Imidazoleglycerol-phosphate dehydratase
B8X06_RS11265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B8X06_RS11270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B8X06_RS11275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B8X06_RS11280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B8X06_RS11305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B8X06_RS11320	COG3548	integral membrane protein
B8X06_RS11340	COG1368	sulfuric ester hydrolase activity
B8X06_RS11345	COG0584	glycerophosphoryl diester phosphodiesterase
B8X06_RS11355	COG0492	ferredoxin-NADP+ reductase activity
B8X06_RS11365	COG4932	domain protein
B8X06_RS11370	COG2326	polyphosphate kinase activity
B8X06_RS11375	COG0778	Nitroreductase
B8X06_RS11385	COG0328	RNA-DNA hybrid ribonuclease activity
B8X06_RS11390	COG4975	Glucose uptake
B8X06_RS11405	COG1349	DNA-binding transcription factor activity
B8X06_RS11410	COG1882	Formate acetyltransferase
B8X06_RS11430	COG1609	Transcriptional regulator
B8X06_RS11435	COG1737	Transcriptional regulator
B8X06_RS11440	COG0673	inositol 2-dehydrogenase activity
B8X06_RS11445	COG0673	inositol 2-dehydrogenase activity
B8X06_RS11450	COG0025	NhaP-type Na H and K H
B8X06_RS11455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B8X06_RS11460	COG1335	isochorismatase
B8X06_RS11470	COG1131	(ABC) transporter
B8X06_RS11475	COG1725	Transcriptional regulator
B8X06_RS11515	COG0028	Belongs to the TPP enzyme family
B8X06_RS11525	COG1073	alpha beta
B8X06_RS11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B8X06_RS11535	COG0626	cystathionine gamma-synthase activity
B8X06_RS11565	COG0095	Lipoate-protein ligase
B8X06_RS11570	COG1705	Flagellar rod assembly protein muramidase FlgJ
B8X06_RS11580	COG3716	PTS system mannose fructose sorbose family IID component
B8X06_RS11585	COG3715	PTS system
B8X06_RS11590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS11595	COG2188	Transcriptional regulator
B8X06_RS11600	COG0589	response to stress
B8X06_RS11605	COG0564	pseudouridine synthase activity
B8X06_RS11610	COG1396	sequence-specific DNA binding
B8X06_RS11625	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B8X06_RS11635	COG2188	Transcriptional regulator
B8X06_RS11640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B8X06_RS11650	COG1418	mRNA catabolic process
B8X06_RS11680	COG1253	flavin adenine dinucleotide binding
B8X06_RS11685	COG1780	Probably involved in ribonucleotide reductase function
B8X06_RS11690	COG0025	NhaP-type Na H and K H
B8X06_RS11695	COG2814	Major facilitator Superfamily
B8X06_RS11700	COG0789	Transcriptional regulator
B8X06_RS11705	COG0604	alcohol dehydrogenase
B8X06_RS11715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B8X06_RS11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B8X06_RS11730	COG0436	Aminotransferase
B8X06_RS11750	COG0583	DNA-binding transcription factor activity
B8X06_RS11755	COG0702	epimerase
B8X06_RS11770	COG1074	ATP-dependent DNA helicase activity
B8X06_RS11775	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B8X06_RS11785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B8X06_RS11790	COG0284	orotidine-5'-phosphate decarboxylase activity
B8X06_RS11795	COG0167	dihydroorotate dehydrogenase activity
B8X06_RS11800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B8X06_RS11805	COG0505	Belongs to the CarA family
B8X06_RS11810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B8X06_RS11815	COG0540	Belongs to the ATCase OTCase family
B8X06_RS11820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B8X06_RS11825	COG2508	Transcriptional regulator
B8X06_RS11830	COG2233	PERMEase
B8X06_RS11835	COG2252	PERMEase
B8X06_RS11855	COG1215	transferase activity, transferring glycosyl groups
B8X06_RS11865	COG0151	Belongs to the GarS family
B8X06_RS11870	COG0138	bifunctional purine biosynthesis protein purh
B8X06_RS11875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B8X06_RS11880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B8X06_RS11895	COG0047	phosphoribosylformylglycinamidine synthase activity
B8X06_RS11900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B8X06_RS11905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B8X06_RS11910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B8X06_RS11920	COG1053	succinate dehydrogenase
B8X06_RS11920	COG3976	FMN-binding domain protein
B8X06_RS11920	COG0431	NADPH-dependent FMN reductase
B8X06_RS11925	COG1053	succinate dehydrogenase
B8X06_RS11925	COG0431	NADPH-dependent FMN reductase
B8X06_RS11925	COG3976	FMN-binding domain protein
B8X06_RS11930	COG0095	Lipoate-protein ligase
B8X06_RS11935	COG2365	Tyrosine phosphatase family
B8X06_RS11955	COG1136	(ABC) transporter
B8X06_RS11970	COG1725	Transcriptional regulator
B8X06_RS11975	COG1131	(ABC) transporter
B8X06_RS11985	COG0589	response to stress
B8X06_RS11995	COG2246	polysaccharide biosynthetic process
B8X06_RS12015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B8X06_RS12035	COG0366	Alpha amylase catalytic
B8X06_RS12045	COG0561	phosphatase activity
B8X06_RS12055	COG0110	maltose O-acetyltransferase activity
B8X06_RS12060	COG0494	nUDIX hydrolase
B8X06_RS12095	COG1827	regulation of RNA biosynthetic process
B8X06_RS12100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B8X06_RS12105	COG1309	transcriptional regulator
B8X06_RS12115	COG1131	(ABC) transporter
B8X06_RS12120	COG3048	D-serine ammonia-lyase activity
B8X06_RS12125	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS12130	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS12135	COG1447	Phosphotransferase system cellobiose-specific component IIA
B8X06_RS12140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS12145	COG2188	Transcriptional regulator
B8X06_RS12150	COG1216	Glycosyl transferase, family 2
B8X06_RS12165	COG0561	phosphatase activity
B8X06_RS12170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B8X06_RS12195	COG0716	FMN binding
B8X06_RS12215	COG0710	3-dehydroquinate dehydratase activity
B8X06_RS12220	COG0531	amino acid
B8X06_RS12265	COG4720	Psort location CytoplasmicMembrane, score
B8X06_RS12270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B8X06_RS12285	COG4990	cell redox homeostasis
B8X06_RS12310	COG1811	Na channel or pump
B8X06_RS12315	COG0789	Transcriptional regulator
B8X06_RS12315	COG4978	Transcriptional regulator
B8X06_RS12330	COG0577	efflux transmembrane transporter activity
B8X06_RS12335	COG1136	(ABC) transporter
B8X06_RS12375	COG2814	Major facilitator Superfamily
B8X06_RS12385	COG2814	Major facilitator Superfamily
B8X06_RS12395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B8X06_RS12400	COG2855	membrane
B8X06_RS12405	COG0583	DNA-binding transcription factor activity
B8X06_RS12415	COG0438	transferase activity, transferring glycosyl groups
B8X06_RS12430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B8X06_RS12440	COG4152	abc transporter atp-binding protein
B8X06_RS12450	COG4221	oxidoreductase activity
B8X06_RS12465	COG0789	Transcriptional regulator
B8X06_RS12485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B8X06_RS12510	COG0456	acetyltransferase
B8X06_RS12535	COG0583	DNA-binding transcription factor activity
B8X06_RS12545	COG1063	alcohol dehydrogenase
B8X06_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS12555	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS12575	COG4975	Glucose uptake
B8X06_RS12585	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS12590	COG0583	DNA-binding transcription factor activity
B8X06_RS12610	COG4221	oxidoreductase activity
B8X06_RS12615	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS12635	COG0589	response to stress
B8X06_RS12640	COG0110	maltose O-acetyltransferase activity
B8X06_RS12645	COG1011	Hydrolase
B8X06_RS12660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B8X06_RS12670	COG0667	Aldo Keto reductase
B8X06_RS12675	COG1132	(ABC) transporter
B8X06_RS12680	COG1132	(ABC) transporter
B8X06_RS12685	COG2814	Major facilitator Superfamily
B8X06_RS12700	COG1511	domain protein
B8X06_RS12700	COG1511	domain protein
B8X06_RS12710	COG0640	Transcriptional regulator
B8X06_RS12735	COG0488	(ABC) transporter
B8X06_RS12740	COG0561	phosphatase activity
B8X06_RS12750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B8X06_RS12765	COG2270	Major facilitator Superfamily
B8X06_RS12805	COG2200	EAL domain
B8X06_RS12815	COG1328	CTP reductase activity
B8X06_RS12825	COG0242	peptide deformylase activity
B8X06_RS12835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B8X06_RS12855	COG0583	DNA-binding transcription factor activity
B8X06_RS12865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B8X06_RS12925	COG0697	spore germination
B8X06_RS12950	COG1940	carbohydrate kinase activity
B8X06_RS12955	COG1132	(ABC) transporter
B8X06_RS12965	COG0778	Nitroreductase
B8X06_RS12970	COG1263	PTS System
B8X06_RS12970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS12970	COG2190	(PTS) system
B8X06_RS12980	COG4120	Belongs to the binding-protein-dependent transport system permease family
B8X06_RS13010	COG0617	tRNA 3'-terminal CCA addition
B8X06_RS13010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B8X06_RS13010	COG3620	sequence-specific DNA binding
B8X06_RS13015	COG0410	ABC transporter
B8X06_RS13030	COG0559	Belongs to the binding-protein-dependent transport system permease family
B8X06_RS13045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B8X06_RS13045	COG5549	protein import
B8X06_RS13050	COG2246	polysaccharide biosynthetic process
B8X06_RS13060	COG1914	H( )-stimulated, divalent metal cation uptake system
B8X06_RS13080	COG0640	Transcriptional regulator
B8X06_RS13125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS13130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS13135	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS13145	COG0789	Transcriptional regulator
B8X06_RS13150	COG0741	lytic transglycosylase activity
B8X06_RS13170	COG0803	Belongs to the bacterial solute-binding protein 9 family
B8X06_RS13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B8X06_RS13210	COG4221	oxidoreductase activity
B8X06_RS13255	COG1132	(ABC) transporter
B8X06_RS13260	COG1132	(ABC) transporter
B8X06_RS13270	COG1473	amidohydrolase
B8X06_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS13290	COG0531	amino acid
B8X06_RS13320	COG2217	Heavy metal translocating P-type atpase
B8X06_RS13390	COG1063	alcohol dehydrogenase
B8X06_RS13430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B8X06_RS13435	COG1733	regulation of RNA biosynthetic process
B8X06_RS13440	COG2814	Major facilitator Superfamily
B8X06_RS13450	COG0367	asparagine synthase
B8X06_RS13455	COG3279	Response regulator of the LytR AlgR family
B8X06_RS13470	COG1309	transcriptional regulator
B8X06_RS13480	COG1012	belongs to the aldehyde dehydrogenase family
B8X06_RS13495	COG1733	regulation of RNA biosynthetic process
B8X06_RS13505	COG0300	oxidoreductase activity
B8X06_RS13525	COG4989	oxidoreductase activity
B8X06_RS13540	COG0477	Major facilitator Superfamily
B8X06_RS13550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B8X06_RS13555	COG1120	ATPase activity
B8X06_RS13560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B8X06_RS13565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B8X06_RS13570	COG1309	transcriptional regulator
B8X06_RS13580	COG4221	oxidoreductase activity
B8X06_RS13585	COG0110	maltose O-acetyltransferase activity
B8X06_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
B8X06_RS13625	COG0481	GTPase activity
B8X06_RS13640	COG2816	NAD+ diphosphatase activity
B8X06_RS13650	COG1053	succinate dehydrogenase
B8X06_RS13660	COG0783	Belongs to the Dps family
B8X06_RS13670	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS13675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS13695	COG0789	Transcriptional regulator
B8X06_RS13715	COG0693	protein deglycase activity
B8X06_RS13740	COG0577	efflux transmembrane transporter activity
B8X06_RS13740	COG1136	(ABC) transporter
B8X06_RS13750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B8X06_RS13765	COG1376	ErfK ybiS ycfS ynhG family protein
B8X06_RS13770	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS13785	COG0477	Major facilitator Superfamily
B8X06_RS13820	COG0588	phosphoglycerate mutase activity
B8X06_RS13825	COG0628	permease
B8X06_RS13830	COG1846	Transcriptional regulator
B8X06_RS13830	COG1940	carbohydrate kinase activity
B8X06_RS13840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B8X06_RS13850	COG0515	serine threonine protein kinase
B8X06_RS13850	COG2815	serine threonine protein kinase
B8X06_RS13890	COG1247	-acetyltransferase
B8X06_RS13895	COG1686	Belongs to the peptidase S11 family
B8X06_RS13915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B8X06_RS13920	COG0516	GMP reductase activity
B8X06_RS13920	COG0517	IMP dehydrogenase activity
B8X06_RS13930	COG0012	GTP binding
B8X06_RS13935	COG4481	Protein conserved in bacteria
B8X06_RS13940	COG1475	DNA binding
B8X06_RS13945	COG1192	Involved in chromosome partitioning
B8X06_RS13955	COG0357	Ribosomal RNA small subunit methyltransferase G
B8X06_RS13960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B8X06_RS13975	COG0583	DNA-binding transcription factor activity
B8X06_RS13980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B8X06_RS13985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B8X06_RS13990	COG0765	amino acid transport
B8X06_RS13995	COG1126	abc transporter atp-binding protein
B8X06_RS14000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B8X06_RS14025	COG1263	PTS System
B8X06_RS14025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS14025	COG2190	(PTS) system
B8X06_RS14030	COG0366	Alpha amylase catalytic
B8X06_RS14035	COG1609	Transcriptional regulator
B8X06_RS14050	COG0390	transport system, permease component
B8X06_RS14055	COG4619	ABC transporter
B8X06_RS14060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B8X06_RS14075	COG0561	phosphatase activity
B8X06_RS14085	COG0383	alpha-mannosidase activity
B8X06_RS14090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS14090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS14090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS14095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS14100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS14100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B8X06_RS14100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS14105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B8X06_RS14105	COG3711	transcriptional antiterminator
B8X06_RS14120	COG1263	PTS System
B8X06_RS14120	COG2190	(PTS) system
B8X06_RS14120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS14150	COG0735	belongs to the Fur family
B8X06_RS14175	COG1380	Effector of murein hydrolase LrgA
B8X06_RS14185	COG1307	EDD domain protein, DegV family
B8X06_RS14195	COG2738	Putative neutral zinc metallopeptidase
B8X06_RS14200	COG1233	COG1233 Phytoene dehydrogenase and related
B8X06_RS14205	COG1562	ergosterol biosynthetic process
B8X06_RS14215	COG1929	Belongs to the glycerate kinase type-1 family
B8X06_RS14230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B8X06_RS14235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B8X06_RS14240	COG0516	GMP reductase activity
B8X06_RS14245	COG2365	Tyrosine phosphatase family
B8X06_RS14250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B8X06_RS14260	COG0531	amino acid
B8X06_RS14265	COG3158	transport of potassium into the cell
B8X06_RS14270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B8X06_RS14275	COG0628	permease
B8X06_RS14280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B8X06_RS14295	COG1272	protein, Hemolysin III
B8X06_RS14300	COG0640	Transcriptional regulator
B8X06_RS14335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B8X06_RS14345	COG0302	gtp cyclohydrolase
B8X06_RS14350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B8X06_RS14370	COG0803	Belongs to the bacterial solute-binding protein 9 family
B8X06_RS14375	COG2814	Major facilitator Superfamily
B8X06_RS14405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B8X06_RS14410	COG1882	Formate acetyltransferase
B8X06_RS14415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B8X06_RS14425	COG2151	metal-sulfur cluster biosynthetic enzyme
B8X06_RS14430	COG4989	oxidoreductase activity
B8X06_RS14465	COG2217	Heavy metal translocating P-type atpase
B8X06_RS14475	COG2315	Protein conserved in bacteria
B8X06_RS14485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B8X06_RS14490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B8X06_RS14505	COG1757	Na H antiporter
B8X06_RS14510	COG1113	amino acid transport
B8X06_RS14520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B8X06_RS14535	COG1393	Belongs to the ArsC family
B8X06_RS14540	COG3189	MarR family transcriptional regulator
B8X06_RS14550	COG1194	a g-specific adenine glycosylase
B8X06_RS14565	COG0071	Belongs to the small heat shock protein (HSP20) family
B8X06_RS14585	COG0697	spore germination
B8X06_RS14600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B8X06_RS14625	COG0477	Major facilitator Superfamily
B8X06_RS14685	COG0737	Belongs to the 5'-nucleotidase family
B8X06_RS14695	COG0656	L-ascorbic acid biosynthetic process
B8X06_RS14715	COG1968	undecaprenyl-diphosphatase activity
B8X06_RS14720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B8X06_RS14755	COG2207	Transcriptional regulator
B8X06_RS14780	COG0076	glutamate decarboxylase activity
B8X06_RS14850	COG2226	methyltransferase
B8X06_RS14870	COG2217	Heavy metal translocating P-type atpase
B8X06_RS14875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS14880	COG3118	belongs to the thioredoxin family
B8X06_RS14885	COG1937	Protein conserved in bacteria
B8X06_RS14905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B8X06_RS14910	COG3590	peptidase
B8X06_RS14935	COG0446	pyridine nucleotide-disulphide oxidoreductase
B8X06_RS14985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B8X06_RS14995	COG1114	Component of the transport system for branched-chain amino acids
B8X06_RS15005	COG1874	Beta-galactosidase
B8X06_RS15010	COG1609	Transcriptional regulator
B8X06_RS15020	COG0477	Major facilitator Superfamily
B8X06_RS15040	COG2184	nucleotidyltransferase activity
B8X06_RS15045	COG2944	sequence-specific DNA binding
B8X06_RS15055	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B8X06_RS15060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B8X06_RS15065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B8X06_RS15085	COG2190	(PTS) system
B8X06_RS15085	COG2211	Major facilitator Superfamily
B8X06_RS15090	COG2017	converts alpha-aldose to the beta-anomer
B8X06_RS15095	COG1609	Transcriptional regulator
B8X06_RS15100	COG0667	Aldo Keto reductase
B8X06_RS15120	COG0710	3-dehydroquinate dehydratase activity
B8X06_RS15125	COG0738	Major facilitator superfamily
B8X06_RS15130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B8X06_RS15135	COG0583	DNA-binding transcription factor activity
B8X06_RS15140	COG0738	Major facilitator superfamily
B8X06_RS15150	COG2267	carboxylic ester hydrolase activity
B8X06_RS15155	COG2188	Transcriptional regulator
B8X06_RS15160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B8X06_RS15165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B8X06_RS15170	COG2971	BadF BadG BcrA BcrD
B8X06_RS15180	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS15190	COG3711	transcriptional antiterminator
B8X06_RS15195	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS15200	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS15205	COG1263	PTS System
B8X06_RS15205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B8X06_RS15205	COG2190	(PTS) system
B8X06_RS15225	COG2211	Major facilitator Superfamily
B8X06_RS15250	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B8X06_RS15265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B8X06_RS15285	COG3711	transcriptional antiterminator
B8X06_RS15300	COG3775	system Galactitol-specific IIC component
B8X06_RS15305	COG3414	Phosphotransferase system galactitol-specific IIB component
B8X06_RS15315	COG1349	DNA-binding transcription factor activity
B8X06_RS15320	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B8X06_RS15330	COG0110	maltose O-acetyltransferase activity
B8X06_RS15335	COG2160	L-arabinose isomerase activity
B8X06_RS15355	COG1609	Transcriptional regulator
B8X06_RS15360	COG1737	Transcriptional regulator
B8X06_RS15380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B8X06_RS15400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B8X06_RS15405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B8X06_RS15435	COG2261	transglycosylase associated protein
B8X06_RS15445	COG1393	Belongs to the ArsC family
B8X06_RS15465	COG4512	PFAM Accessory gene regulator B
B8X06_RS15480	COG1304	FMN binding
B8X06_RS15485	COG0028	Belongs to the TPP enzyme family
B8X06_RS15490	COG1959	2 iron, 2 sulfur cluster binding
B8X06_RS15495	COG0028	Belongs to the TPP enzyme family
B8X06_RS15510	COG0235	Class ii aldolase
B8X06_RS15520	COG3254	rhamnose metabolic process
B8X06_RS15525	COG1070	Carbohydrate kinase
B8X06_RS15530	COG2814	Major facilitator Superfamily
B8X06_RS15535	COG2207	Transcriptional regulator
B8X06_RS15540	COG1349	DNA-binding transcription factor activity
B8X06_RS15620	COG1609	Transcriptional regulator
B8X06_RS15620	COG2207	Transcriptional regulator
B8X06_RS15665	COG2723	6-phospho-beta-galactosidase activity
B8X06_RS15670	COG1940	carbohydrate kinase activity
B8X06_RS15675	COG0383	alpha-mannosidase activity
B8X06_RS15685	COG2188	Transcriptional regulator
B8X06_RS15695	COG3842	ATPase activity
B8X06_RS15705	COG2207	Transcriptional regulator
B8X06_RS15705	COG4753	response regulator
B8X06_RS15710	COG2972	Histidine kinase
B8X06_RS15720	COG0366	Alpha amylase catalytic
B8X06_RS15725	COG1653	transport
B8X06_RS15730	COG0395	ABC-type sugar transport system, permease component
B8X06_RS15745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B8X06_RS15745	COG2207	Transcriptional regulator
B8X06_RS15750	COG1132	(ABC) transporter
B8X06_RS15755	COG1132	(ABC) transporter
B8X06_RS15760	COG2188	Transcriptional regulator
B8X06_RS15775	COG3732	PTS system glucitol sorbitol-specific
B8X06_RS15780	COG3730	PTS system glucitol sorbitol-specific
B8X06_RS15800	COG4975	Glucose uptake
B8X06_RS15805	COG1869	D-ribose catabolic process
B8X06_RS15815	COG1609	Transcriptional regulator
B8X06_RS15820	COG1012	belongs to the aldehyde dehydrogenase family
B8X06_RS15820	COG1454	alcohol dehydrogenase
B8X06_RS15830	COG1695	Transcriptional regulator
B8X06_RS15835	COG3479	Phenolic acid decarboxylase
B8X06_RS15850	COG1307	EDD domain protein, DegV family
B8X06_RS15890	COG0445	tRNA wobble uridine modification
B8X06_RS15895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B8X06_RS15900	COG1847	R3H domain protein
B8X06_RS15910	COG4166	transmembrane transport
B8X06_RS15915	COG0706	membrane insertase activity
B8X06_RS15920	COG0594	ribonuclease P activity
B8X06_RS15925	COG0230	Belongs to the bacterial ribosomal protein bL34 family