locus-tag	class	description
DNA52_RS00065	COG0110	maltose O-acetyltransferase activity
DNA52_RS00075	COG0561	phosphatase activity
DNA52_RS00085	COG0561	phosphatase activity
DNA52_RS00090	COG1114	Component of the transport system for branched-chain amino acids
DNA52_RS00135	COG0463	Glycosyl transferase, family 2
DNA52_RS00160	COG3279	Response regulator of the LytR AlgR family
DNA52_RS00185	COG2274	protein secretion by the type I secretion system
DNA52_RS00220	COG3973	AAA domain
DNA52_RS00225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNA52_RS00230	COG0180	Tryptophanyl-tRNA synthetase
DNA52_RS00235	COG2188	Transcriptional regulator
DNA52_RS00240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS00255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS00260	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS00265	COG1940	carbohydrate kinase activity
DNA52_RS00275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DNA52_RS00290	COG0248	Ppx GppA phosphatase
DNA52_RS00305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DNA52_RS00310	COG1801	Protein of unknown function DUF72
DNA52_RS00320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA52_RS00320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA52_RS00325	COG2814	Major facilitator Superfamily
DNA52_RS00330	COG0084	hydrolase, TatD family'
DNA52_RS00335	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DNA52_RS00340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DNA52_RS00345	COG4466	Protein conserved in bacteria
DNA52_RS00350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DNA52_RS00360	COG1073	alpha beta
DNA52_RS00365	COG1121	(ABC) transporter
DNA52_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNA52_RS00370	COG1321	iron dependent repressor
DNA52_RS00390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNA52_RS00395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNA52_RS00405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNA52_RS00425	COG1078	dGTPase activity
DNA52_RS00430	COG0095	Lipoate-protein ligase
DNA52_RS00440	COG3343	RNA polymerase activity
DNA52_RS00445	COG0504	CTP synthase activity
DNA52_RS00450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DNA52_RS00455	COG0814	amino acid
DNA52_RS00465	COG1760	l-serine dehydratase
DNA52_RS00470	COG1760	l-serine dehydratase
DNA52_RS00485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNA52_RS00490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DNA52_RS00495	COG0254	rRNA binding
DNA52_RS00505	COG3764	Sortase (surface protein transpeptidase)
DNA52_RS00510	COG1704	LemA family
DNA52_RS00515	COG0501	Belongs to the peptidase M48B family
DNA52_RS00525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNA52_RS00545	COG0736	holo-[acyl-carrier-protein] synthase activity
DNA52_RS00550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DNA52_RS00555	COG2337	Toxic component of a toxin-antitoxin (TA) module
DNA52_RS00560	COG3158	transport of potassium into the cell
DNA52_RS00580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNA52_RS00585	COG0505	Belongs to the CarA family
DNA52_RS00590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DNA52_RS00595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DNA52_RS00600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DNA52_RS00605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNA52_RS00610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DNA52_RS00625	COG2267	carboxylic ester hydrolase activity
DNA52_RS00645	COG0039	L-malate dehydrogenase activity
DNA52_RS00650	COG0193	aminoacyl-tRNA hydrolase activity
DNA52_RS00655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DNA52_RS00660	COG2244	polysaccharide biosynthetic process
DNA52_RS00665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DNA52_RS00675	COG1098	S1 RNA binding domain
DNA52_RS00680	COG0037	tRNA processing
DNA52_RS00695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DNA52_RS00700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DNA52_RS00705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DNA52_RS00745	COG3104	oligopeptide transport
DNA52_RS00795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DNA52_RS00805	COG2188	Transcriptional regulator
DNA52_RS00815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DNA52_RS00820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DNA52_RS00835	COG2183	response to ionizing radiation
DNA52_RS00840	COG3091	SprT-like family
DNA52_RS00845	COG0460	homoserine dehydrogenase
DNA52_RS00850	COG0083	homoserine kinase activity
DNA52_RS00865	COG3409	Peptidoglycan-binding domain 1 protein
DNA52_RS00890	COG3715	PTS system
DNA52_RS00895	COG3716	PTS system mannose fructose sorbose family IID component
DNA52_RS00910	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DNA52_RS00910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DNA52_RS00915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS00915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS00920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS00920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS00925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNA52_RS00935	COG0439	Biotin carboxylase
DNA52_RS00945	COG0825	malonyl-CoA metabolic process
DNA52_RS00950	COG1316	TRANSCRIPTIONal
DNA52_RS00960	COG0697	spore germination
DNA52_RS00965	COG0588	phosphoglycerate mutase activity
DNA52_RS00980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DNA52_RS00990	COG0756	dUTP diphosphatase activity
DNA52_RS01015	COG4956	integral membrane protein (PIN domain superfamily)
DNA52_RS01020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DNA52_RS01025	COG0215	cysteine-tRNA ligase activity
DNA52_RS01030	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DNA52_RS01035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNA52_RS01050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNA52_RS01060	COG0250	Participates in transcription elongation, termination and antitermination
DNA52_RS01070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DNA52_RS01075	COG0081	regulation of translation
DNA52_RS01080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DNA52_RS01085	COG0222	ribosome binding
DNA52_RS01105	COG1611	Belongs to the LOG family
DNA52_RS01115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNA52_RS01120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DNA52_RS01125	COG2813	Specifically methylates the guanine in position
DNA52_RS01140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DNA52_RS01145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DNA52_RS01150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DNA52_RS01160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DNA52_RS01165	COG3870	Protein conserved in bacteria
DNA52_RS01170	COG0470	DNA polymerase III
DNA52_RS01175	COG4467	Involved in initiation control of chromosome replication
DNA52_RS01190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNA52_RS01195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DNA52_RS01200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNA52_RS01205	COG3639	organic phosphonate transmembrane transporter activity
DNA52_RS01215	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DNA52_RS01225	COG1214	PFAM Peptidase M22, glycoprotease
DNA52_RS01230	COG0456	acetyltransferase
DNA52_RS01235	COG0456	acetyltransferase
DNA52_RS01240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DNA52_RS01250	COG0488	(ABC) transporter
DNA52_RS01255	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DNA52_RS01265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DNA52_RS01270	COG0459	protein refolding
DNA52_RS01275	COG0531	amino acid
DNA52_RS01280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNA52_RS01285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DNA52_RS01290	COG1739	Uncharacterized protein family UPF0029
DNA52_RS01295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DNA52_RS01310	COG0653	protein targeting
DNA52_RS01325	COG0745	RESPONSE REGULATOR receiver
DNA52_RS01330	COG5002	protein histidine kinase activity
DNA52_RS01335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DNA52_RS01340	COG0573	inorganic phosphate transmembrane transporter activity
DNA52_RS01345	COG0581	inorganic phosphate transmembrane transporter activity
DNA52_RS01350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNA52_RS01355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNA52_RS01360	COG0704	Plays a role in the regulation of phosphate uptake
DNA52_RS01365	COG1983	PspC domain protein
DNA52_RS01370	COG1950	PFAM Membrane protein of
DNA52_RS01375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DNA52_RS01380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DNA52_RS01385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DNA52_RS01390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DNA52_RS01405	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS01425	COG1215	transferase activity, transferring glycosyl groups
DNA52_RS01440	COG0492	ferredoxin-NADP+ reductase activity
DNA52_RS01445	COG2323	membrane
DNA52_RS01455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNA52_RS01465	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS01475	COG2814	Major facilitator Superfamily
DNA52_RS01485	COG0556	nucleotide-excision repair
DNA52_RS01490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNA52_RS01495	COG1854	S-ribosylhomocysteine lyase activity
DNA52_RS01500	COG0137	argininosuccinate synthase activity
DNA52_RS01505	COG0165	Argininosuccinate lyase
DNA52_RS01515	COG1660	Displays ATPase and GTPase activities
DNA52_RS01525	COG1481	regulation of sporulation
DNA52_RS01535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNA52_RS01540	COG0740	serine-type endopeptidase activity
DNA52_RS01550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DNA52_RS01555	COG2390	Transcriptional regulator
DNA52_RS01565	COG0126	phosphoglycerate kinase activity
DNA52_RS01570	COG0149	triose-phosphate isomerase activity
DNA52_RS01575	COG0148	phosphopyruvate hydratase activity
DNA52_RS01590	COG0038	chloride channel
DNA52_RS01595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNA52_RS01605	COG0557	exoribonuclease II activity
DNA52_RS01610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DNA52_RS01620	COG0765	amino acid transport
DNA52_RS01625	COG1126	abc transporter atp-binding protein
DNA52_RS01635	COG0561	phosphatase activity
DNA52_RS01640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DNA52_RS01645	COG0280	phosphate acetyltransferase
DNA52_RS01650	COG0802	atpase or kinase
DNA52_RS01665	COG0708	Exodeoxyribonuclease III
DNA52_RS01675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DNA52_RS01680	COG0025	NhaP-type Na H and K H
DNA52_RS01705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNA52_RS01710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNA52_RS01720	COG0561	phosphatase activity
DNA52_RS01730	COG2017	converts alpha-aldose to the beta-anomer
DNA52_RS01745	COG0778	Nitroreductase
DNA52_RS01770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNA52_RS01785	COG1393	Belongs to the ArsC family
DNA52_RS01800	COG0477	Major facilitator Superfamily
DNA52_RS01810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DNA52_RS01820	COG3475	LICD family
DNA52_RS01835	COG2252	PERMEase
DNA52_RS01840	COG0028	Belongs to the TPP enzyme family
DNA52_RS01845	COG0196	riboflavin kinase activity
DNA52_RS01850	COG0028	Belongs to the TPP enzyme family
DNA52_RS01855	COG2267	carboxylic ester hydrolase activity
DNA52_RS01865	COG2755	lipolytic protein G-D-S-L family
DNA52_RS01865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DNA52_RS01870	COG2936	dipeptidyl-peptidase activity
DNA52_RS01885	COG0531	amino acid
DNA52_RS01910	COG0194	GDP metabolic process
DNA52_RS01915	COG0735	belongs to the Fur family
DNA52_RS01930	COG0546	phosphoglycolate phosphatase activity
DNA52_RS01935	COG0436	Aminotransferase
DNA52_RS01940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNA52_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNA52_RS01965	COG0765	amino acid transport
DNA52_RS01970	COG0765	amino acid transport
DNA52_RS01975	COG1263	PTS System
DNA52_RS01975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS01975	COG2190	(PTS) system
DNA52_RS01985	COG1263	PTS System
DNA52_RS01985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS01990	COG3394	polysaccharide catabolic process
DNA52_RS01995	COG0531	amino acid
DNA52_RS02005	COG1846	Transcriptional regulator
DNA52_RS02035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DNA52_RS02045	COG2076	Multidrug Resistance protein
DNA52_RS02060	COG0588	phosphoglycerate mutase activity
DNA52_RS02065	COG0569	domain protein
DNA52_RS02065	COG0475	glutathione-regulated potassium exporter activity
DNA52_RS02070	COG0456	acetyltransferase
DNA52_RS02070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DNA52_RS02075	COG3711	transcriptional antiterminator
DNA52_RS02080	COG2190	(PTS) system
DNA52_RS02080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS02080	COG1263	PTS System
DNA52_RS02085	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS02090	COG0586	Pfam SNARE associated Golgi protein
DNA52_RS02095	COG3973	AAA domain
DNA52_RS02105	COG2070	2-Nitropropane dioxygenase
DNA52_RS02110	COG1072	(Pantothenic acid kinase))
DNA52_RS02115	COG0519	Catalyzes the synthesis of GMP from XMP
DNA52_RS02115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DNA52_RS02125	COG1396	sequence-specific DNA binding
DNA52_RS02135	COG1266	CAAX protease self-immunity
DNA52_RS02140	COG1733	regulation of RNA biosynthetic process
DNA52_RS02145	COG2814	Major facilitator Superfamily
DNA52_RS02160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DNA52_RS02160	COG2755	lipolytic protein G-D-S-L family
DNA52_RS02165	COG2261	transglycosylase associated protein
DNA52_RS02180	COG1302	Protein conserved in bacteria
DNA52_RS02210	COG0308	aminopeptidase N
DNA52_RS02215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DNA52_RS02260	COG0572	uridine kinase
DNA52_RS02275	COG0583	DNA-binding transcription factor activity
DNA52_RS02280	COG1053	succinate dehydrogenase
DNA52_RS02290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DNA52_RS02295	COG0017	Asparaginyl-tRNA synthetase
DNA52_RS02300	COG2502	aspartate--ammonia ligase
DNA52_RS02305	COG4690	dipeptidase activity
DNA52_RS02325	COG0514	ATP-dependent DNA helicase (RecQ)
DNA52_RS02330	COG0564	pseudouridine synthase activity
DNA52_RS02335	COG0640	Transcriptional regulator
DNA52_RS02385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DNA52_RS02390	COG0527	aspartate kinase activity
DNA52_RS02395	COG0367	asparagine synthase
DNA52_RS02445	COG2814	Major facilitator Superfamily
DNA52_RS02465	COG1278	Cold shock
DNA52_RS02470	COG2966	Psort location CytoplasmicMembrane, score
DNA52_RS02480	COG1316	TRANSCRIPTIONal
DNA52_RS02500	COG1959	2 iron, 2 sulfur cluster binding
DNA52_RS02505	COG0028	Belongs to the TPP enzyme family
DNA52_RS02510	COG0833	amino acid
DNA52_RS02520	COG1428	Deoxynucleoside kinase
DNA52_RS02525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DNA52_RS02565	COG4463	regulation of RNA biosynthetic process
DNA52_RS02570	COG0542	response to heat
DNA52_RS02580	COG0085	RNA polymerase activity
DNA52_RS02585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DNA52_RS02590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DNA52_RS02595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DNA52_RS02600	COG0049	tRNA binding
DNA52_RS02605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DNA52_RS02610	COG0051	transcription antitermination factor activity, RNA binding
DNA52_RS02615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DNA52_RS02620	COG0088	Forms part of the polypeptide exit tunnel
DNA52_RS02625	COG0089	rRNA binding
DNA52_RS02630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DNA52_RS02635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DNA52_RS02640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DNA52_RS02645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DNA52_RS02650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DNA52_RS02655	COG0255	Belongs to the universal ribosomal protein uL29 family
DNA52_RS02660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DNA52_RS02665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DNA52_RS02670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DNA52_RS02675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DNA52_RS02680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNA52_RS02685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DNA52_RS02690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DNA52_RS02695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DNA52_RS02700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DNA52_RS02705	COG1841	ribosomal large subunit assembly
DNA52_RS02710	COG0200	Binds to the 23S rRNA
DNA52_RS02720	COG0563	adenylate kinase activity
DNA52_RS02725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DNA52_RS02730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DNA52_RS02735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DNA52_RS02740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DNA52_RS02745	COG0202	RNA polymerase activity
DNA52_RS02750	COG0203	ribosomal protein L17
DNA52_RS02775	COG4939	FMN-binding domain protein
DNA52_RS02785	COG1122	ATPase activity
DNA52_RS02790	COG1122	ATPase activity
DNA52_RS02800	COG0101	tRNA pseudouridine synthase activity
DNA52_RS02805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DNA52_RS02810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DNA52_RS02830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DNA52_RS02835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNA52_RS02840	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DNA52_RS02845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DNA52_RS02850	COG0471	metal ion transport
DNA52_RS02855	COG2151	metal-sulfur cluster biosynthetic enzyme
DNA52_RS02860	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DNA52_RS02870	COG1917	Cupin 2, conserved barrel domain protein
DNA52_RS02870	COG4977	sequence-specific DNA binding
DNA52_RS02875	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DNA52_RS02880	COG1121	(ABC) transporter
DNA52_RS02885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNA52_RS02890	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNA52_RS02900	COG0039	L-malate dehydrogenase activity
DNA52_RS02905	COG0471	metal ion transport
DNA52_RS02925	COG3052	prosthetic group binding
DNA52_RS02945	COG0114	fumarate hydratase activity
DNA52_RS02950	COG1053	succinate dehydrogenase
DNA52_RS02960	COG0583	DNA-binding transcription factor activity
DNA52_RS02970	COG0583	DNA-binding transcription factor activity
DNA52_RS02975	COG0281	malic enzyme
DNA52_RS02985	COG0531	amino acid
DNA52_RS02990	COG4684	Psort location CytoplasmicMembrane, score
DNA52_RS03005	COG1271	oxidase subunit
DNA52_RS03010	COG1294	oxidase, subunit
DNA52_RS03015	COG4988	ABC transporter
DNA52_RS03020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DNA52_RS03035	COG0142	geranyltranstransferase activity
DNA52_RS03050	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNA52_RS03055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNA52_RS03060	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DNA52_RS03065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DNA52_RS03075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNA52_RS03080	COG4851	CamS sex pheromone cAM373 precursor
DNA52_RS03085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNA52_RS03090	COG0154	amidase activity
DNA52_RS03095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNA52_RS03100	COG1597	lipid kinase activity
DNA52_RS03105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DNA52_RS03120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS03130	COG1737	Transcriptional regulator
DNA52_RS03145	COG1278	Cold shock
DNA52_RS03150	COG0673	inositol 2-dehydrogenase activity
DNA52_RS03155	COG0513	Belongs to the DEAD box helicase family
DNA52_RS03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS03195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DNA52_RS03205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DNA52_RS03215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNA52_RS03250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNA52_RS03250	COG1215	transferase activity, transferring glycosyl groups
DNA52_RS03255	COG0110	maltose O-acetyltransferase activity
DNA52_RS03285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DNA52_RS03295	COG1088	dTDP-glucose 4,6-dehydratase activity
DNA52_RS03300	COG1091	dTDP-4-dehydrorhamnose reductase activity
DNA52_RS03310	COG0582	viral genome integration into host DNA
DNA52_RS03320	COG0489	protein tyrosine kinase activity
DNA52_RS03325	COG4464	protein tyrosine phosphatase activity
DNA52_RS03335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DNA52_RS03340	COG1216	Glycosyl transferase, family 2
DNA52_RS03350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNA52_RS03350	COG1215	transferase activity, transferring glycosyl groups
DNA52_RS03390	COG0562	UDP-galactopyranose mutase
DNA52_RS03425	COG2207	Transcriptional regulator
DNA52_RS03425	COG1609	Transcriptional regulator
DNA52_RS03445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DNA52_RS03480	COG2137	regulation of response to DNA damage stimulus
DNA52_RS03485	COG3557	Belongs to the UPF0374 family
DNA52_RS03510	COG0628	permease
DNA52_RS03515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DNA52_RS03520	COG2610	gluconate transmembrane transporter activity
DNA52_RS03525	COG1070	Carbohydrate kinase
DNA52_RS03530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DNA52_RS03535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNA52_RS03540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DNA52_RS03575	COG4166	transmembrane transport
DNA52_RS03580	COG0601	transmembrane transport
DNA52_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNA52_RS03590	COG0444	Belongs to the ABC transporter superfamily
DNA52_RS03595	COG4608	Belongs to the ABC transporter superfamily
DNA52_RS03605	COG0582	viral genome integration into host DNA
DNA52_RS03610	COG0542	response to heat
DNA52_RS03630	COG0438	transferase activity, transferring glycosyl groups
DNA52_RS03635	COG0438	transferase activity, transferring glycosyl groups
DNA52_RS03645	COG1686	Belongs to the peptidase S11 family
DNA52_RS03650	COG0436	Aminotransferase
DNA52_RS03655	COG4703	Protein of unknown function (DUF1797)
DNA52_RS03660	COG1368	sulfuric ester hydrolase activity
DNA52_RS03750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNA52_RS03770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DNA52_RS03785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DNA52_RS03790	COG0833	amino acid
DNA52_RS03795	COG2040	homocysteine
DNA52_RS03800	COG0438	transferase activity, transferring glycosyl groups
DNA52_RS03810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DNA52_RS03815	COG0477	Major facilitator Superfamily
DNA52_RS03830	COG0438	transferase activity, transferring glycosyl groups
DNA52_RS03845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DNA52_RS03855	COG0495	leucyl-tRNA aminoacylation
DNA52_RS03860	COG2244	polysaccharide biosynthetic process
DNA52_RS03865	COG1187	pseudouridine synthase activity
DNA52_RS03870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DNA52_RS03875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNA52_RS03885	COG3842	ATPase activity
DNA52_RS03890	COG1175	transmembrane transport
DNA52_RS03895	COG0395	ABC-type sugar transport system, permease component
DNA52_RS03905	COG0584	glycerophosphoryl diester phosphodiesterase
DNA52_RS03910	COG1428	Deoxynucleoside kinase
DNA52_RS03915	COG1970	mechanosensitive ion channel activity
DNA52_RS03920	COG1511	domain protein
DNA52_RS03920	COG1511	domain protein
DNA52_RS03950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DNA52_RS03955	COG0789	Transcriptional regulator
DNA52_RS03965	COG0697	spore germination
DNA52_RS03970	COG0561	phosphatase activity
DNA52_RS03990	COG3279	Response regulator of the LytR AlgR family
DNA52_RS04025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNA52_RS04315	COG0646	methionine synthase
DNA52_RS04315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DNA52_RS04320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNA52_RS04330	COG2046	Belongs to the sulfate adenylyltransferase family
DNA52_RS04335	COG0529	Catalyzes the synthesis of activated sulfate
DNA52_RS04340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DNA52_RS04350	COG3273	potassium ion transport
DNA52_RS04350	COG0471	metal ion transport
DNA52_RS04355	COG0534	Mate efflux family protein
DNA52_RS04375	COG2153	protein acetylation
DNA52_RS04380	COG0018	arginyl-trna synthetase
DNA52_RS04390	COG1136	(ABC) transporter
DNA52_RS04390	COG0577	efflux transmembrane transporter activity
DNA52_RS04405	COG1376	ErfK ybiS ycfS ynhG family protein
DNA52_RS04410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNA52_RS04415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNA52_RS04425	COG0436	Aminotransferase
DNA52_RS04430	COG1438	arginine binding
DNA52_RS04440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNA52_RS04445	COG3679	Belongs to the UPF0342 family
DNA52_RS04450	COG0420	3'-5' exonuclease activity
DNA52_RS04455	COG4717	serine-type aminopeptidase activity
DNA52_RS04460	COG3481	metal-dependent phosphohydrolase, HD sub domain
DNA52_RS04475	COG0583	DNA-binding transcription factor activity
DNA52_RS04485	COG0431	NADPH-dependent FMN reductase
DNA52_RS04485	COG3976	FMN-binding domain protein
DNA52_RS04485	COG1053	succinate dehydrogenase
DNA52_RS04525	COG2217	Heavy metal translocating P-type atpase
DNA52_RS04530	COG0148	phosphopyruvate hydratase activity
DNA52_RS04540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DNA52_RS04550	COG0463	Glycosyl transferase, family 2
DNA52_RS04570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DNA52_RS04570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DNA52_RS04575	COG0307	riboflavin synthase, alpha
DNA52_RS04580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNA52_RS04580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNA52_RS04585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DNA52_RS04600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNA52_RS04610	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS04640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DNA52_RS04650	COG0537	adenosine 5'-monophosphoramidase activity
DNA52_RS04655	COG1131	(ABC) transporter
DNA52_RS04660	COG4473	ABC transporter
DNA52_RS04665	COG0510	thiamine kinase activity
DNA52_RS04670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DNA52_RS04680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA52_RS04685	COG1674	ftsk spoiiie
DNA52_RS04690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DNA52_RS04715	COG0719	Fe-S assembly protein
DNA52_RS04720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNA52_RS04730	COG0719	Fe-S assembly protein
DNA52_RS04735	COG2151	metal-sulfur cluster biosynthetic enzyme
DNA52_RS04750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNA52_RS04750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNA52_RS04755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNA52_RS04760	COG0237	dephospho-CoA kinase activity
DNA52_RS04765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DNA52_RS04770	COG3611	Membrane attachment protein
DNA52_RS04775	COG1484	DNA-dependent DNA replication
DNA52_RS04780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DNA52_RS04785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DNA52_RS04790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DNA52_RS04795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DNA52_RS04805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNA52_RS04810	COG0604	alcohol dehydrogenase
DNA52_RS04815	COG1733	regulation of RNA biosynthetic process
DNA52_RS04825	COG1215	transferase activity, transferring glycosyl groups
DNA52_RS04840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DNA52_RS04845	COG1534	Rna-binding protein
DNA52_RS04850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DNA52_RS04855	COG1713	HD superfamily hydrolase involved in NAD metabolism
DNA52_RS04860	COG0799	negative regulation of ribosome biogenesis
DNA52_RS04865	COG2226	methyltransferase
DNA52_RS04870	COG1323	Belongs to the UPF0348 family
DNA52_RS04880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DNA52_RS04895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DNA52_RS04900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNA52_RS04905	COG0745	RESPONSE REGULATOR receiver
DNA52_RS04910	COG5002	protein histidine kinase activity
DNA52_RS04920	COG0419	ATPase involved in DNA repair
DNA52_RS04935	COG0706	membrane insertase activity
DNA52_RS04940	COG1254	Belongs to the acylphosphatase family
DNA52_RS04945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNA52_RS04955	COG1733	regulation of RNA biosynthetic process
DNA52_RS04960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DNA52_RS04965	COG0072	phenylalanine-tRNA ligase activity
DNA52_RS04965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA52_RS04970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DNA52_RS04975	COG0572	uridine kinase
DNA52_RS04980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DNA52_RS05000	COG4841	protein insertion into membrane
DNA52_RS05010	COG0768	penicillin binding
DNA52_RS05015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNA52_RS05020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DNA52_RS05025	COG0457	Tetratricopeptide repeat
DNA52_RS05025	COG0705	Rhomboid family
DNA52_RS05035	COG1940	carbohydrate kinase activity
DNA52_RS05055	COG0584	glycerophosphoryl diester phosphodiesterase
DNA52_RS05060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DNA52_RS05065	COG0789	Transcriptional regulator
DNA52_RS05115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DNA52_RS05125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DNA52_RS05130	COG0006	proline dipeptidase activity
DNA52_RS05135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DNA52_RS05140	COG1302	Protein conserved in bacteria
DNA52_RS05145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNA52_RS05150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNA52_RS05155	COG1570	exodeoxyribonuclease VII activity
DNA52_RS05160	COG1722	exodeoxyribonuclease VII activity
DNA52_RS05165	COG0142	geranyltranstransferase activity
DNA52_RS05170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DNA52_RS05175	COG1438	arginine binding
DNA52_RS05180	COG0497	DNA recombination
DNA52_RS05195	COG1732	Glycine betaine
DNA52_RS05210	COG0194	GDP metabolic process
DNA52_RS05215	COG1758	RNA polymerase activity
DNA52_RS05220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DNA52_RS05225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DNA52_RS05230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DNA52_RS05235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DNA52_RS05235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNA52_RS05240	COG0631	protein serine/threonine phosphatase activity
DNA52_RS05245	COG2815	serine threonine protein kinase
DNA52_RS05245	COG0515	serine threonine protein kinase
DNA52_RS05250	COG1162	GTPase activity
DNA52_RS05255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DNA52_RS05260	COG1564	THIamine pyrophosphokinase
DNA52_RS05270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DNA52_RS05275	COG1302	Protein conserved in bacteria
DNA52_RS05280	COG1461	Dihydroxyacetone kinase
DNA52_RS05285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DNA52_RS05290	COG0416	fatty acid biosynthetic process
DNA52_RS05295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNA52_RS05300	COG0571	ribonuclease III activity
DNA52_RS05305	COG1196	nuclear chromosome segregation
DNA52_RS05310	COG0552	protein localization to endoplasmic reticulum
DNA52_RS05315	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DNA52_RS05320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DNA52_RS05325	COG0228	four-way junction DNA binding
DNA52_RS05330	COG1837	Belongs to the UPF0109 family
DNA52_RS05335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DNA52_RS05340	COG0336	Belongs to the RNA methyltransferase TrmD family
DNA52_RS05345	COG0335	large ribosomal subunit rRNA binding
DNA52_RS05365	COG1131	(ABC) transporter
DNA52_RS05380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DNA52_RS05380	COG0512	Glutamine amidotransferase of anthranilate synthase
DNA52_RS05385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DNA52_RS05390	COG0134	indole-3-glycerol-phosphate synthase activity
DNA52_RS05395	COG0135	phosphoribosylanthranilate isomerase activity
DNA52_RS05400	COG0133	tryptophan synthase activity
DNA52_RS05405	COG0159	tryptophan synthase activity
DNA52_RS05430	COG1473	amidohydrolase
DNA52_RS05435	COG1063	alcohol dehydrogenase
DNA52_RS05445	COG0300	oxidoreductase activity
DNA52_RS05455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNA52_RS05460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNA52_RS05465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNA52_RS05470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DNA52_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS05480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNA52_RS05495	COG0439	Biotin carboxylase
DNA52_RS05510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DNA52_RS05520	COG1811	Na channel or pump
DNA52_RS05525	COG0583	DNA-binding transcription factor activity
DNA52_RS05530	COG1607	acyl-coa hydrolase
DNA52_RS05535	COG1162	GTPase activity
DNA52_RS05545	COG0477	Major facilitator Superfamily
DNA52_RS05555	COG0582	viral genome integration into host DNA
DNA52_RS05560	COG0270	DNA (cytosine-5-)-methyltransferase activity
DNA52_RS05605	COG1396	sequence-specific DNA binding
DNA52_RS05620	COG1396	sequence-specific DNA binding
DNA52_RS05700	COG1476	TRANSCRIPTIONal
DNA52_RS05720	COG1783	phage Terminase large subunit
DNA52_RS05820	COG1388	LysM domain
DNA52_RS05820	COG3942	CHAP domain
DNA52_RS05845	COG3397	chitin binding
DNA52_RS05850	COG3153	acetyltransferase
DNA52_RS05905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DNA52_RS05910	COG3397	chitin binding
DNA52_RS05925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DNA52_RS05935	COG3152	Membrane
DNA52_RS05940	COG1597	lipid kinase activity
DNA52_RS05955	COG2261	transglycosylase associated protein
DNA52_RS05960	COG3237	CsbD-like
DNA52_RS05975	COG1942	4-Oxalocrotonate Tautomerase
DNA52_RS06015	COG0531	amino acid
DNA52_RS06020	COG0561	phosphatase activity
DNA52_RS06025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DNA52_RS06025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DNA52_RS06045	COG2017	converts alpha-aldose to the beta-anomer
DNA52_RS06050	COG1304	FMN binding
DNA52_RS06075	COG1199	ATP-dependent helicase activity
DNA52_RS06075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DNA52_RS06090	COG0017	Asparaginyl-tRNA synthetase
DNA52_RS06105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNA52_RS06110	COG2011	ABC-type metal ion transport system permease component
DNA52_RS06115	COG1464	Belongs to the NlpA lipoprotein family
DNA52_RS06125	COG1177	transmembrane transport
DNA52_RS06130	COG1840	ABC-type Fe3 transport system, periplasmic component
DNA52_RS06145	COG3331	DNA recombination
DNA52_RS06150	COG4474	Belongs to the UPF0398 family
DNA52_RS06155	COG3599	regulation of cell shape
DNA52_RS06165	COG0116	Belongs to the methyltransferase superfamily
DNA52_RS06170	COG1073	alpha beta
DNA52_RS06180	COG1216	Glycosyl transferase, family 2
DNA52_RS06200	COG1619	proteins homologs of microcin C7 resistance protein MccF
DNA52_RS06225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNA52_RS06240	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DNA52_RS06245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DNA52_RS06250	COG0564	pseudouridine synthase activity
DNA52_RS06255	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DNA52_RS06260	COG0505	Belongs to the CarA family
DNA52_RS06265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNA52_RS06280	COG5646	InterPro IPR014922
DNA52_RS06305	COG1131	(ABC) transporter
DNA52_RS06310	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DNA52_RS06315	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DNA52_RS06325	COG1307	EDD domain protein, DegV family
DNA52_RS06385	COG1113	amino acid transport
DNA52_RS06395	COG2814	Major facilitator Superfamily
DNA52_RS06410	COG0583	DNA-binding transcription factor activity
DNA52_RS06415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNA52_RS06425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DNA52_RS06430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DNA52_RS06435	COG0758	DNA mediated transformation
DNA52_RS06440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DNA52_RS06445	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DNA52_RS06450	COG4974	Belongs to the 'phage' integrase family
DNA52_RS06455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DNA52_RS06460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DNA52_RS06470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DNA52_RS06475	COG0187	DNA topoisomerase II activity
DNA52_RS06485	COG0583	DNA-binding transcription factor activity
DNA52_RS06490	COG1227	inorganic diphosphatase activity
DNA52_RS06495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DNA52_RS06530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNA52_RS06535	COG1846	Transcriptional regulator
DNA52_RS06560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DNA52_RS06570	COG1620	l-lactate permease
DNA52_RS06590	COG3409	Peptidoglycan-binding domain 1 protein
DNA52_RS06590	COG0793	Belongs to the peptidase S41A family
DNA52_RS06595	COG4479	Belongs to the UPF0346 family
DNA52_RS06600	COG4698	Protein conserved in bacteria
DNA52_RS06605	COG2755	lipolytic protein G-D-S-L family
DNA52_RS06610	COG1307	EDD domain protein, DegV family
DNA52_RS06615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DNA52_RS06620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DNA52_RS06625	COG0488	(ABC) transporter
DNA52_RS06635	COG0617	tRNA 3'-terminal CCA addition
DNA52_RS06640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DNA52_RS06645	COG0561	phosphatase activity
DNA52_RS06650	COG0457	Tetratricopeptide repeat
DNA52_RS06665	COG1160	GTP binding
DNA52_RS06670	COG0539	negative regulation of cytoplasmic translation
DNA52_RS06675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DNA52_RS06685	COG0514	ATP-dependent DNA helicase (RecQ)
DNA52_RS06695	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DNA52_RS06700	COG1187	pseudouridine synthase activity
DNA52_RS06705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DNA52_RS06710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DNA52_RS06720	COG4974	Belongs to the 'phage' integrase family
DNA52_RS06725	COG2996	Protein conserved in bacteria
DNA52_RS06745	COG0205	6-phosphofructokinase activity
DNA52_RS06750	COG0587	DNA-directed DNA polymerase activity
DNA52_RS06760	COG0542	response to heat
DNA52_RS06770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DNA52_RS06775	COG2384	SAM-dependent methyltransferase
DNA52_RS06800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNA52_RS06800	COG0574	Belongs to the PEP-utilizing enzyme family
DNA52_RS06810	COG1846	Transcriptional regulator
DNA52_RS06830	COG2217	Heavy metal translocating P-type atpase
DNA52_RS06835	COG0148	phosphopyruvate hydratase activity
DNA52_RS06840	COG0477	Major facilitator Superfamily
DNA52_RS06850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNA52_RS06855	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS06860	COG1349	DNA-binding transcription factor activity
DNA52_RS06870	COG1393	Belongs to the ArsC family
DNA52_RS06890	COG0546	phosphoglycolate phosphatase activity
DNA52_RS06920	COG0583	DNA-binding transcription factor activity
DNA52_RS06925	COG0604	alcohol dehydrogenase
DNA52_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS06940	COG2197	response regulator
DNA52_RS06945	COG4585	Histidine kinase
DNA52_RS06955	COG1131	(ABC) transporter
DNA52_RS06965	COG0519	Catalyzes the synthesis of GMP from XMP
DNA52_RS06980	COG1131	(ABC) transporter
DNA52_RS07000	COG1131	(ABC) transporter
DNA52_RS07005	COG1725	Transcriptional regulator
DNA52_RS07015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DNA52_RS07020	COG0358	DNA primase activity
DNA52_RS07025	COG0751	glycine-tRNA ligase activity
DNA52_RS07030	COG0752	glycyl-tRNA synthetase alpha subunit
DNA52_RS07035	COG1381	Involved in DNA repair and RecF pathway recombination
DNA52_RS07040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DNA52_RS07045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DNA52_RS07050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DNA52_RS07055	COG1702	phosphate starvation-inducible protein PhoH
DNA52_RS07060	COG1610	YqeY-like protein
DNA52_RS07065	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DNA52_RS07070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DNA52_RS07080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DNA52_RS07090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNA52_RS07100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DNA52_RS07105	COG0124	histidyl-tRNA synthetase
DNA52_RS07110	COG4991	sh3 domain protein
DNA52_RS07110	COG3103	Sh3 type 3 domain protein
DNA52_RS07110	COG0860	N-Acetylmuramoyl-L-alanine amidase
DNA52_RS07115	COG3001	Fructosamine kinase
DNA52_RS07120	COG0546	phosphoglycolate phosphatase activity
DNA52_RS07125	COG1490	D-aminoacyl-tRNA deacylase activity
DNA52_RS07130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DNA52_RS07140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DNA52_RS07145	COG2264	protein methyltransferase activity
DNA52_RS07150	COG2094	Belongs to the DNA glycosylase MPG family
DNA52_RS07165	COG0481	GTPase activity
DNA52_RS07170	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DNA52_RS07175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNA52_RS07180	COG1696	Membrane protein involved in D-alanine export
DNA52_RS07185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNA52_RS07195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNA52_RS07200	COG0484	heat shock protein binding
DNA52_RS07205	COG0443	Heat shock 70 kDa protein
DNA52_RS07210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DNA52_RS07215	COG1420	regulation of RNA biosynthetic process
DNA52_RS07220	COG3527	Alpha-acetolactate decarboxylase
DNA52_RS07225	COG0196	riboflavin kinase activity
DNA52_RS07230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DNA52_RS07235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DNA52_RS07240	COG0287	Prephenate dehydrogenase
DNA52_RS07245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DNA52_RS07255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DNA52_RS07260	COG0738	Major facilitator superfamily
DNA52_RS07265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DNA52_RS07270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DNA52_RS07280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DNA52_RS07285	COG0195	Participates in both transcription termination and antitermination
DNA52_RS07290	COG0779	Required for maturation of 30S ribosomal subunits
DNA52_RS07295	COG2176	DNA-directed DNA polymerase activity
DNA52_RS07300	COG0442	prolyl-tRNA aminoacylation
DNA52_RS07305	COG0750	zinc metalloprotease
DNA52_RS07310	COG4589	Belongs to the CDS family
DNA52_RS07315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DNA52_RS07320	COG0233	cytoplasmic translational termination
DNA52_RS07325	COG0528	UMP kinase activity
DNA52_RS07330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DNA52_RS07335	COG0052	Belongs to the universal ribosomal protein uS2 family
DNA52_RS07345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNA52_RS07350	COG2827	Endonuclease containing a URI domain
DNA52_RS07355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DNA52_RS07360	COG0204	Acyl-transferase
DNA52_RS07365	COG3763	UPF0154 protein
DNA52_RS07370	COG4224	UPF0291 protein
DNA52_RS07375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DNA52_RS07390	COG3425	synthase
DNA52_RS07405	COG0463	Glycosyl transferase, family 2
DNA52_RS07415	COG1316	TRANSCRIPTIONal
DNA52_RS07420	COG1116	anion transmembrane transporter activity
DNA52_RS07430	COG0772	Belongs to the SEDS family
DNA52_RS07450	COG0393	Putative heavy-metal-binding
DNA52_RS07465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNA52_RS07470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DNA52_RS07470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DNA52_RS07475	COG5416	Lipopolysaccharide assembly protein A domain
DNA52_RS07480	COG0300	oxidoreductase activity
DNA52_RS07485	COG1234	tRNA 3'-trailer cleavage
DNA52_RS07495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DNA52_RS07500	COG1349	DNA-binding transcription factor activity
DNA52_RS07505	COG1105	Belongs to the carbohydrate kinase PfkB family
DNA52_RS07510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS07510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS07510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS07515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DNA52_RS07540	COG0297	glycogen (starch) synthase activity
DNA52_RS07545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DNA52_RS07550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNA52_RS07560	COG0489	protein tyrosine kinase activity
DNA52_RS07570	COG0322	excinuclease ABC activity
DNA52_RS07575	COG1126	abc transporter atp-binding protein
DNA52_RS07580	COG0765	amino acid transport
DNA52_RS07600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DNA52_RS07605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DNA52_RS07610	COG0544	peptidyl-prolyl cis-trans isomerase activity
DNA52_RS07615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DNA52_RS07640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DNA52_RS07645	COG0268	Binds directly to 16S ribosomal RNA
DNA52_RS07650	COG1466	dna polymerase III delta subunit
DNA52_RS07655	COG2333	competence protein COMEC
DNA52_RS07655	COG0658	competence protein
DNA52_RS07660	COG2131	deaminase
DNA52_RS07665	COG1555	photosystem II stabilization
DNA52_RS07665	COG1596	polysaccharide export
DNA52_RS07670	COG3480	Lon protease (S16) C-terminal proteolytic domain
DNA52_RS07675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DNA52_RS07680	COG0742	ribosomal rna small subunit methyltransferase
DNA52_RS07685	COG4471	UPF0298 protein
DNA52_RS07690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DNA52_RS07695	COG0772	Belongs to the SEDS family
DNA52_RS07730	COG1217	gtp-binding protein TYPA
DNA52_RS07735	COG0483	inositol monophosphate 1-phosphatase activity
DNA52_RS07740	COG4476	Belongs to the UPF0223 family
DNA52_RS07745	COG0039	L-malate dehydrogenase activity
DNA52_RS07770	COG0242	peptide deformylase activity
DNA52_RS07780	COG5503	Protein of unknown function (DUF1447)
DNA52_RS07785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DNA52_RS07790	COG1597	lipid kinase activity
DNA52_RS07800	COG1388	LysM domain
DNA52_RS07800	COG3584	3D domain protein
DNA52_RS07805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNA52_RS07810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DNA52_RS07845	COG0569	domain protein
DNA52_RS07850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DNA52_RS07855	COG0482	sulfurtransferase activity
DNA52_RS07865	COG1104	cysteine desulfurase activity
DNA52_RS07870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DNA52_RS07880	COG0494	nUDIX hydrolase
DNA52_RS07885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DNA52_RS07895	COG3279	Response regulator of the LytR AlgR family
DNA52_RS07910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DNA52_RS07915	COG3599	regulation of cell shape
DNA52_RS07925	COG0762	integral membrane protein
DNA52_RS07930	COG1799	cell septum assembly
DNA52_RS07945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DNA52_RS07950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNA52_RS07955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DNA52_RS07960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNA52_RS07965	COG0768	penicillin binding
DNA52_RS07975	COG0275	rRNA processing
DNA52_RS07980	COG2001	Belongs to the MraZ family
DNA52_RS08000	COG1674	ftsk spoiiie
DNA52_RS08005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DNA52_RS08015	COG1114	Component of the transport system for branched-chain amino acids
DNA52_RS08030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNA52_RS08035	COG0628	permease
DNA52_RS08045	COG2706	6-phosphogluconolactonase activity
DNA52_RS08050	COG3142	Participates in the control of copper homeostasis
DNA52_RS08055	COG0564	pseudouridine synthase activity
DNA52_RS08060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DNA52_RS08065	COG2357	RelA SpoT domain protein
DNA52_RS08075	COG1164	Oligoendopeptidase f
DNA52_RS08085	COG4862	establishment of competence for transformation
DNA52_RS08090	COG1393	Belongs to the ArsC family
DNA52_RS08095	COG1234	tRNA 3'-trailer cleavage
DNA52_RS08240	COG1098	S1 RNA binding domain
DNA52_RS08250	COG0586	Pfam SNARE associated Golgi protein
DNA52_RS08260	COG0647	UMP catabolic process
DNA52_RS08265	COG4470	Protein conserved in bacteria
DNA52_RS08270	COG0737	Belongs to the 5'-nucleotidase family
DNA52_RS08285	COG1113	amino acid transport
DNA52_RS08290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DNA52_RS08295	COG0827	DNA restriction-modification system
DNA52_RS08325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DNA52_RS08335	COG0217	transcriptional regulatory protein
DNA52_RS08350	COG1609	Transcriptional regulator
DNA52_RS08355	COG0006	proline dipeptidase activity
DNA52_RS08360	COG0789	Transcriptional regulator
DNA52_RS08375	COG0668	transmembrane transport
DNA52_RS08380	COG1473	amidohydrolase
DNA52_RS08385	COG2171	N-acyltransferase activity
DNA52_RS08390	COG0517	IMP dehydrogenase activity
DNA52_RS08400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DNA52_RS08405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DNA52_RS08410	COG1719	4-vinyl reductase, 4VR
DNA52_RS08415	COG3118	belongs to the thioredoxin family
DNA52_RS08420	COG1193	negative regulation of DNA recombination
DNA52_RS08430	COG3906	Belongs to the UPF0473 family
DNA52_RS08435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DNA52_RS08440	COG4472	Bacterial protein of unknown function (DUF965)
DNA52_RS08445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DNA52_RS08450	COG0513	Belongs to the DEAD box helicase family
DNA52_RS08455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DNA52_RS08460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNA52_RS08465	COG1862	Preprotein translocase
DNA52_RS08470	COG0343	queuine tRNA-ribosyltransferase activity
DNA52_RS08475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DNA52_RS08480	COG2255	four-way junction helicase activity
DNA52_RS08485	COG0632	four-way junction helicase activity
DNA52_RS08515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DNA52_RS08520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DNA52_RS08525	COG1692	metallophosphoesterase
DNA52_RS08530	COG1418	mRNA catabolic process
DNA52_RS08535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DNA52_RS08540	COG1058	Belongs to the CinA family
DNA52_RS08540	COG1546	Belongs to the CinA family
DNA52_RS08545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DNA52_RS08550	COG1426	Protein conserved in bacteria
DNA52_RS08555	COG0612	Peptidase, M16
DNA52_RS08560	COG0612	Peptidase, M16
DNA52_RS08565	COG0527	aspartate kinase activity
DNA52_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNA52_RS08580	COG1126	abc transporter atp-binding protein
DNA52_RS08585	COG0765	amino acid transport
DNA52_RS08590	COG2894	cell division
DNA52_RS08595	COG0850	regulation of cytokinetic process
DNA52_RS08605	COG1792	Involved in formation and maintenance of cell shape
DNA52_RS08610	COG1077	Cell shape determining protein MreB Mrl
DNA52_RS08615	COG2003	Belongs to the UPF0758 family
DNA52_RS08620	COG0285	dihydrofolate synthase activity
DNA52_RS08625	COG0525	valine-tRNA ligase activity
DNA52_RS08635	COG2918	glutathione biosynthetic process
DNA52_RS08635	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNA52_RS08645	COG0301	tRNA thio-modification
DNA52_RS08650	COG1104	cysteine desulfurase activity
DNA52_RS08660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DNA52_RS08665	COG1956	GAF domain-containing protein
DNA52_RS08670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DNA52_RS08675	COG4493	Belongs to the UPF0637 family
DNA52_RS08690	COG0640	Transcriptional regulator
DNA52_RS08695	COG0366	Alpha amylase catalytic
DNA52_RS08705	COG3716	PTS system mannose fructose sorbose family IID component
DNA52_RS08710	COG3715	PTS system
DNA52_RS08715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS08720	COG1609	Transcriptional regulator
DNA52_RS08725	COG2918	glutathione biosynthetic process
DNA52_RS08725	COG0189	ligase activity
DNA52_RS08730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNA52_RS08745	COG0589	response to stress
DNA52_RS08765	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNA52_RS08785	COG1464	Belongs to the NlpA lipoprotein family
DNA52_RS08790	COG2011	ABC-type metal ion transport system permease component
DNA52_RS08795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNA52_RS08800	COG0509	glycine decarboxylation via glycine cleavage system
DNA52_RS08805	COG0772	Belongs to the SEDS family
DNA52_RS08815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DNA52_RS08820	COG1077	Cell shape determining protein MreB Mrl
DNA52_RS08830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNA52_RS08835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DNA52_RS08840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DNA52_RS08845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DNA52_RS08850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DNA52_RS08855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNA52_RS08860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DNA52_RS08865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNA52_RS08870	COG0356	it plays a direct role in the translocation of protons across the membrane
DNA52_RS08875	COG2233	PERMEase
DNA52_RS08885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DNA52_RS08890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNA52_RS08895	COG0009	L-threonylcarbamoyladenylate synthase
DNA52_RS08900	COG2890	protein-(glutamine-N5) methyltransferase activity
DNA52_RS08905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DNA52_RS08910	COG1435	thymidine kinase activity
DNA52_RS08915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNA52_RS08920	COG3442	glutamine amidotransferase
DNA52_RS08925	COG1482	cell wall glycoprotein biosynthetic process
DNA52_RS08930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNA52_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DNA52_RS08955	COG1132	(ABC) transporter
DNA52_RS08970	COG0726	polysaccharide deacetylase
DNA52_RS09015	COG4886	Leucine-rich repeat (LRR) protein
DNA52_RS09015	COG4932	domain protein
DNA52_RS09060	COG1132	(ABC) transporter
DNA52_RS09070	COG1136	(ABC) transporter
DNA52_RS09070	COG0577	efflux transmembrane transporter activity
DNA52_RS09080	COG0166	Belongs to the GPI family
DNA52_RS09085	COG4975	Glucose uptake
DNA52_RS09090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DNA52_RS09095	COG5002	protein histidine kinase activity
DNA52_RS09095	COG3850	Histidine kinase
DNA52_RS09100	COG0745	RESPONSE REGULATOR receiver
DNA52_RS09105	COG2848	UPF0210 protein
DNA52_RS09110	COG3830	Belongs to the UPF0237 family
DNA52_RS09135	COG0477	Major facilitator Superfamily
DNA52_RS09155	COG0791	NLP P60 protein
DNA52_RS09160	COG1522	sequence-specific DNA binding
DNA52_RS09180	COG0488	(ABC) transporter
DNA52_RS09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS09210	COG2190	(PTS) system
DNA52_RS09210	COG1263	PTS System
DNA52_RS09215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNA52_RS09220	COG1307	EDD domain protein, DegV family
DNA52_RS09230	COG2873	o-acetylhomoserine
DNA52_RS09235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DNA52_RS09250	COG4120	Belongs to the binding-protein-dependent transport system permease family
DNA52_RS09260	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS09270	COG2084	Dehydrogenase
DNA52_RS09275	COG0861	Integral membrane protein TerC family
DNA52_RS09280	COG0110	maltose O-acetyltransferase activity
DNA52_RS09285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNA52_RS09290	COG0140	phosphoribosyl-ATP diphosphatase activity
DNA52_RS09295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DNA52_RS09300	COG0107	imidazoleglycerol-phosphate synthase activity
DNA52_RS09305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DNA52_RS09310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DNA52_RS09315	COG0131	Imidazoleglycerol-phosphate dehydratase
DNA52_RS09320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DNA52_RS09325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DNA52_RS09330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DNA52_RS09335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNA52_RS09360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DNA52_RS09375	COG3548	integral membrane protein
DNA52_RS09395	COG1368	sulfuric ester hydrolase activity
DNA52_RS09400	COG0584	glycerophosphoryl diester phosphodiesterase
DNA52_RS09410	COG0492	ferredoxin-NADP+ reductase activity
DNA52_RS09420	COG4932	domain protein
DNA52_RS09425	COG2326	polyphosphate kinase activity
DNA52_RS09430	COG0778	Nitroreductase
DNA52_RS09440	COG0328	RNA-DNA hybrid ribonuclease activity
DNA52_RS09445	COG4975	Glucose uptake
DNA52_RS09460	COG1349	DNA-binding transcription factor activity
DNA52_RS09465	COG1882	Formate acetyltransferase
DNA52_RS09485	COG1609	Transcriptional regulator
DNA52_RS09490	COG1737	Transcriptional regulator
DNA52_RS09495	COG0673	inositol 2-dehydrogenase activity
DNA52_RS09500	COG0673	inositol 2-dehydrogenase activity
DNA52_RS09505	COG0025	NhaP-type Na H and K H
DNA52_RS09510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNA52_RS09515	COG1335	isochorismatase
DNA52_RS09525	COG1131	(ABC) transporter
DNA52_RS09530	COG1725	Transcriptional regulator
DNA52_RS09570	COG0028	Belongs to the TPP enzyme family
DNA52_RS09580	COG1073	alpha beta
DNA52_RS09585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNA52_RS09590	COG0626	cystathionine gamma-synthase activity
DNA52_RS09620	COG0095	Lipoate-protein ligase
DNA52_RS09625	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNA52_RS09635	COG3716	PTS system mannose fructose sorbose family IID component
DNA52_RS09640	COG3715	PTS system
DNA52_RS09645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS09650	COG2188	Transcriptional regulator
DNA52_RS09655	COG0589	response to stress
DNA52_RS09660	COG0564	pseudouridine synthase activity
DNA52_RS09665	COG1396	sequence-specific DNA binding
DNA52_RS09680	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DNA52_RS09690	COG2188	Transcriptional regulator
DNA52_RS09695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DNA52_RS09705	COG1418	mRNA catabolic process
DNA52_RS09735	COG1253	flavin adenine dinucleotide binding
DNA52_RS09740	COG1780	Probably involved in ribonucleotide reductase function
DNA52_RS09745	COG0025	NhaP-type Na H and K H
DNA52_RS09750	COG2814	Major facilitator Superfamily
DNA52_RS09755	COG0789	Transcriptional regulator
DNA52_RS09760	COG0604	alcohol dehydrogenase
DNA52_RS09770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DNA52_RS09780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNA52_RS09785	COG0436	Aminotransferase
DNA52_RS09805	COG0583	DNA-binding transcription factor activity
DNA52_RS09810	COG0702	epimerase
DNA52_RS09820	COG1074	ATP-dependent DNA helicase activity
DNA52_RS09825	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DNA52_RS09835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DNA52_RS09840	COG0284	orotidine-5'-phosphate decarboxylase activity
DNA52_RS09845	COG0167	dihydroorotate dehydrogenase activity
DNA52_RS09850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNA52_RS09855	COG0505	Belongs to the CarA family
DNA52_RS09860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DNA52_RS09865	COG0540	Belongs to the ATCase OTCase family
DNA52_RS09870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DNA52_RS09875	COG2508	Transcriptional regulator
DNA52_RS09880	COG2233	PERMEase
DNA52_RS09885	COG2252	PERMEase
DNA52_RS09905	COG1215	transferase activity, transferring glycosyl groups
DNA52_RS09915	COG0151	Belongs to the GarS family
DNA52_RS09920	COG0138	bifunctional purine biosynthesis protein purh
DNA52_RS09925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DNA52_RS09930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DNA52_RS09940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNA52_RS09945	COG0047	phosphoribosylformylglycinamidine synthase activity
DNA52_RS09950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNA52_RS09955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DNA52_RS09960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DNA52_RS09970	COG3976	FMN-binding domain protein
DNA52_RS09970	COG1053	succinate dehydrogenase
DNA52_RS09970	COG0431	NADPH-dependent FMN reductase
DNA52_RS09975	COG3976	FMN-binding domain protein
DNA52_RS09975	COG1053	succinate dehydrogenase
DNA52_RS09975	COG0431	NADPH-dependent FMN reductase
DNA52_RS09980	COG0095	Lipoate-protein ligase
DNA52_RS09985	COG2365	Tyrosine phosphatase family
DNA52_RS10005	COG1136	(ABC) transporter
DNA52_RS10020	COG1725	Transcriptional regulator
DNA52_RS10025	COG1131	(ABC) transporter
DNA52_RS10035	COG0589	response to stress
DNA52_RS10045	COG2246	polysaccharide biosynthetic process
DNA52_RS10065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DNA52_RS10085	COG0366	Alpha amylase catalytic
DNA52_RS10095	COG0561	phosphatase activity
DNA52_RS10105	COG0110	maltose O-acetyltransferase activity
DNA52_RS10110	COG0494	nUDIX hydrolase
DNA52_RS10145	COG1827	regulation of RNA biosynthetic process
DNA52_RS10150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DNA52_RS10155	COG1309	transcriptional regulator
DNA52_RS10165	COG1131	(ABC) transporter
DNA52_RS10175	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS10180	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS10185	COG1447	Phosphotransferase system cellobiose-specific component IIA
DNA52_RS10190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS10195	COG2188	Transcriptional regulator
DNA52_RS10200	COG1216	Glycosyl transferase, family 2
DNA52_RS10215	COG0561	phosphatase activity
DNA52_RS10220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNA52_RS10245	COG0716	FMN binding
DNA52_RS10265	COG0710	3-dehydroquinate dehydratase activity
DNA52_RS10270	COG0531	amino acid
DNA52_RS10315	COG4720	Psort location CytoplasmicMembrane, score
DNA52_RS10320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DNA52_RS10335	COG4990	cell redox homeostasis
DNA52_RS10360	COG1811	Na channel or pump
DNA52_RS10365	COG4978	Transcriptional regulator
DNA52_RS10365	COG0789	Transcriptional regulator
DNA52_RS10380	COG0577	efflux transmembrane transporter activity
DNA52_RS10385	COG1136	(ABC) transporter
DNA52_RS10425	COG2814	Major facilitator Superfamily
DNA52_RS10435	COG2814	Major facilitator Superfamily
DNA52_RS10445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNA52_RS10450	COG2855	membrane
DNA52_RS10455	COG0583	DNA-binding transcription factor activity
DNA52_RS10465	COG0438	transferase activity, transferring glycosyl groups
DNA52_RS10480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DNA52_RS10490	COG4152	abc transporter atp-binding protein
DNA52_RS10500	COG4221	oxidoreductase activity
DNA52_RS10515	COG0789	Transcriptional regulator
DNA52_RS10535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DNA52_RS10560	COG0456	acetyltransferase
DNA52_RS10585	COG0583	DNA-binding transcription factor activity
DNA52_RS10595	COG1063	alcohol dehydrogenase
DNA52_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS10605	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS10625	COG4975	Glucose uptake
DNA52_RS10635	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS10640	COG0583	DNA-binding transcription factor activity
DNA52_RS10660	COG4221	oxidoreductase activity
DNA52_RS10665	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS10685	COG0589	response to stress
DNA52_RS10690	COG0110	maltose O-acetyltransferase activity
DNA52_RS10695	COG1011	Hydrolase
DNA52_RS10710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DNA52_RS10720	COG0667	Aldo Keto reductase
DNA52_RS10725	COG1132	(ABC) transporter
DNA52_RS10730	COG1132	(ABC) transporter
DNA52_RS10735	COG2814	Major facilitator Superfamily
DNA52_RS10750	COG1511	domain protein
DNA52_RS10750	COG1511	domain protein
DNA52_RS10760	COG0640	Transcriptional regulator
DNA52_RS10785	COG0488	(ABC) transporter
DNA52_RS10790	COG0561	phosphatase activity
DNA52_RS10800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNA52_RS10815	COG2270	Major facilitator Superfamily
DNA52_RS10855	COG2200	EAL domain
DNA52_RS10865	COG1328	CTP reductase activity
DNA52_RS10875	COG0242	peptide deformylase activity
DNA52_RS10885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DNA52_RS10905	COG0583	DNA-binding transcription factor activity
DNA52_RS10915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DNA52_RS10975	COG0697	spore germination
DNA52_RS11000	COG1940	carbohydrate kinase activity
DNA52_RS11005	COG1132	(ABC) transporter
DNA52_RS11015	COG0778	Nitroreductase
DNA52_RS11020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS11020	COG1263	PTS System
DNA52_RS11020	COG2190	(PTS) system
DNA52_RS11025	COG1116	anion transmembrane transporter activity
DNA52_RS11030	COG4120	Belongs to the binding-protein-dependent transport system permease family
DNA52_RS11065	COG0410	ABC transporter
DNA52_RS11080	COG0559	Belongs to the binding-protein-dependent transport system permease family
DNA52_RS11095	COG5549	protein import
DNA52_RS11095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNA52_RS11100	COG2246	polysaccharide biosynthetic process
DNA52_RS11110	COG1914	H( )-stimulated, divalent metal cation uptake system
DNA52_RS11130	COG0640	Transcriptional regulator
DNA52_RS11140	COG0577	efflux transmembrane transporter activity
DNA52_RS11140	COG1136	(ABC) transporter
DNA52_RS11175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS11180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS11185	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS11195	COG0789	Transcriptional regulator
DNA52_RS11200	COG0741	lytic transglycosylase activity
DNA52_RS11220	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNA52_RS11245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNA52_RS11260	COG4221	oxidoreductase activity
DNA52_RS11305	COG1132	(ABC) transporter
DNA52_RS11310	COG1132	(ABC) transporter
DNA52_RS11320	COG1473	amidohydrolase
DNA52_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS11340	COG0531	amino acid
DNA52_RS11370	COG2217	Heavy metal translocating P-type atpase
DNA52_RS11430	COG1063	alcohol dehydrogenase
DNA52_RS11470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNA52_RS11475	COG1733	regulation of RNA biosynthetic process
DNA52_RS11480	COG2814	Major facilitator Superfamily
DNA52_RS11490	COG0367	asparagine synthase
DNA52_RS11495	COG3279	Response regulator of the LytR AlgR family
DNA52_RS11510	COG1309	transcriptional regulator
DNA52_RS11520	COG1012	belongs to the aldehyde dehydrogenase family
DNA52_RS11535	COG1733	regulation of RNA biosynthetic process
DNA52_RS11540	COG0300	oxidoreductase activity
DNA52_RS11560	COG4989	oxidoreductase activity
DNA52_RS11565	COG0477	Major facilitator Superfamily
DNA52_RS11575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNA52_RS11580	COG1120	ATPase activity
DNA52_RS11585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNA52_RS11590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNA52_RS11595	COG1309	transcriptional regulator
DNA52_RS11605	COG4221	oxidoreductase activity
DNA52_RS11610	COG0110	maltose O-acetyltransferase activity
DNA52_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS11655	COG0481	GTPase activity
DNA52_RS11665	COG2816	NAD+ diphosphatase activity
DNA52_RS11675	COG1053	succinate dehydrogenase
DNA52_RS11685	COG0783	Belongs to the Dps family
DNA52_RS11695	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS11700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS11720	COG0789	Transcriptional regulator
DNA52_RS11740	COG0693	protein deglycase activity
DNA52_RS11765	COG1136	(ABC) transporter
DNA52_RS11765	COG0577	efflux transmembrane transporter activity
DNA52_RS11775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DNA52_RS11795	COG1376	ErfK ybiS ycfS ynhG family protein
DNA52_RS11800	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS11815	COG0477	Major facilitator Superfamily
DNA52_RS11850	COG0588	phosphoglycerate mutase activity
DNA52_RS11855	COG0628	permease
DNA52_RS11860	COG1940	carbohydrate kinase activity
DNA52_RS11860	COG1846	Transcriptional regulator
DNA52_RS11870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DNA52_RS11880	COG0515	serine threonine protein kinase
DNA52_RS11880	COG2815	serine threonine protein kinase
DNA52_RS11920	COG1247	-acetyltransferase
DNA52_RS11925	COG1686	Belongs to the peptidase S11 family
DNA52_RS11945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DNA52_RS11950	COG0517	IMP dehydrogenase activity
DNA52_RS11950	COG0516	GMP reductase activity
DNA52_RS11960	COG0012	GTP binding
DNA52_RS11965	COG4481	Protein conserved in bacteria
DNA52_RS11970	COG1475	DNA binding
DNA52_RS11975	COG1192	Involved in chromosome partitioning
DNA52_RS11985	COG0357	Ribosomal RNA small subunit methyltransferase G
DNA52_RS11990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DNA52_RS12005	COG0583	DNA-binding transcription factor activity
DNA52_RS12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNA52_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNA52_RS12020	COG0765	amino acid transport
DNA52_RS12025	COG1126	abc transporter atp-binding protein
DNA52_RS12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNA52_RS12055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS12055	COG2190	(PTS) system
DNA52_RS12055	COG1263	PTS System
DNA52_RS12060	COG0366	Alpha amylase catalytic
DNA52_RS12065	COG1609	Transcriptional regulator
DNA52_RS12080	COG0390	transport system, permease component
DNA52_RS12085	COG4619	ABC transporter
DNA52_RS12090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DNA52_RS12105	COG0561	phosphatase activity
DNA52_RS12115	COG0383	alpha-mannosidase activity
DNA52_RS12120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS12120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS12120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS12125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS12130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS12130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS12130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNA52_RS12135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS12135	COG3711	transcriptional antiterminator
DNA52_RS12150	COG2190	(PTS) system
DNA52_RS12150	COG1263	PTS System
DNA52_RS12150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS12180	COG0735	belongs to the Fur family
DNA52_RS12205	COG1380	Effector of murein hydrolase LrgA
DNA52_RS12215	COG1307	EDD domain protein, DegV family
DNA52_RS12225	COG2738	Putative neutral zinc metallopeptidase
DNA52_RS12230	COG1233	COG1233 Phytoene dehydrogenase and related
DNA52_RS12235	COG1562	ergosterol biosynthetic process
DNA52_RS12245	COG1929	Belongs to the glycerate kinase type-1 family
DNA52_RS12260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNA52_RS12265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DNA52_RS12270	COG0516	GMP reductase activity
DNA52_RS12275	COG2365	Tyrosine phosphatase family
DNA52_RS12280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DNA52_RS12290	COG0531	amino acid
DNA52_RS12295	COG3158	transport of potassium into the cell
DNA52_RS12300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DNA52_RS12305	COG0628	permease
DNA52_RS12310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNA52_RS12325	COG1272	protein, Hemolysin III
DNA52_RS12330	COG0640	Transcriptional regulator
DNA52_RS12365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DNA52_RS12375	COG0302	gtp cyclohydrolase
DNA52_RS12380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DNA52_RS12400	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNA52_RS12405	COG2814	Major facilitator Superfamily
DNA52_RS12435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNA52_RS12440	COG1882	Formate acetyltransferase
DNA52_RS12445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DNA52_RS12455	COG2151	metal-sulfur cluster biosynthetic enzyme
DNA52_RS12460	COG4989	oxidoreductase activity
DNA52_RS12495	COG2217	Heavy metal translocating P-type atpase
DNA52_RS12505	COG2315	Protein conserved in bacteria
DNA52_RS12515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DNA52_RS12520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNA52_RS12535	COG1757	Na H antiporter
DNA52_RS12540	COG1113	amino acid transport
DNA52_RS12550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DNA52_RS12565	COG1393	Belongs to the ArsC family
DNA52_RS12570	COG3189	MarR family transcriptional regulator
DNA52_RS12580	COG1194	a g-specific adenine glycosylase
DNA52_RS12595	COG0071	Belongs to the small heat shock protein (HSP20) family
DNA52_RS12615	COG0697	spore germination
DNA52_RS12630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DNA52_RS12655	COG0477	Major facilitator Superfamily
DNA52_RS12715	COG0737	Belongs to the 5'-nucleotidase family
DNA52_RS12725	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS12745	COG1968	undecaprenyl-diphosphatase activity
DNA52_RS12750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DNA52_RS12785	COG2207	Transcriptional regulator
DNA52_RS12810	COG0076	glutamate decarboxylase activity
DNA52_RS12860	COG2226	methyltransferase
DNA52_RS12880	COG2217	Heavy metal translocating P-type atpase
DNA52_RS12885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNA52_RS12890	COG3118	belongs to the thioredoxin family
DNA52_RS12895	COG1937	Protein conserved in bacteria
DNA52_RS12915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNA52_RS12920	COG3590	peptidase
DNA52_RS12945	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNA52_RS12995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNA52_RS13005	COG1114	Component of the transport system for branched-chain amino acids
DNA52_RS13015	COG1874	Beta-galactosidase
DNA52_RS13020	COG1609	Transcriptional regulator
DNA52_RS13030	COG0477	Major facilitator Superfamily
DNA52_RS13050	COG2184	nucleotidyltransferase activity
DNA52_RS13055	COG2944	sequence-specific DNA binding
DNA52_RS13060	COG1609	Transcriptional regulator
DNA52_RS13065	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DNA52_RS13070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNA52_RS13075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DNA52_RS13095	COG2190	(PTS) system
DNA52_RS13095	COG2211	Major facilitator Superfamily
DNA52_RS13100	COG2017	converts alpha-aldose to the beta-anomer
DNA52_RS13105	COG1609	Transcriptional regulator
DNA52_RS13110	COG0667	Aldo Keto reductase
DNA52_RS13130	COG0710	3-dehydroquinate dehydratase activity
DNA52_RS13135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNA52_RS13140	COG0583	DNA-binding transcription factor activity
DNA52_RS13145	COG2271	Major facilitator Superfamily
DNA52_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS13175	COG2271	Major facilitator Superfamily
DNA52_RS13185	COG2267	carboxylic ester hydrolase activity
DNA52_RS13190	COG2188	Transcriptional regulator
DNA52_RS13195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS13200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DNA52_RS13205	COG2971	BadF BadG BcrA BcrD
DNA52_RS13215	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS13225	COG3711	transcriptional antiterminator
DNA52_RS13230	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS13235	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS13240	COG1263	PTS System
DNA52_RS13240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS13240	COG2190	(PTS) system
DNA52_RS13260	COG2211	Major facilitator Superfamily
DNA52_RS13275	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DNA52_RS13290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DNA52_RS13310	COG3711	transcriptional antiterminator
DNA52_RS13325	COG3775	system Galactitol-specific IIC component
DNA52_RS13330	COG3414	Phosphotransferase system galactitol-specific IIB component
DNA52_RS13340	COG1349	DNA-binding transcription factor activity
DNA52_RS13345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DNA52_RS13355	COG0110	maltose O-acetyltransferase activity
DNA52_RS13360	COG2160	L-arabinose isomerase activity
DNA52_RS13380	COG1609	Transcriptional regulator
DNA52_RS13385	COG1737	Transcriptional regulator
DNA52_RS13405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNA52_RS13425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNA52_RS13430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DNA52_RS13460	COG2261	transglycosylase associated protein
DNA52_RS13470	COG1393	Belongs to the ArsC family
DNA52_RS13490	COG4512	PFAM Accessory gene regulator B
DNA52_RS13505	COG1304	FMN binding
DNA52_RS13510	COG0028	Belongs to the TPP enzyme family
DNA52_RS13515	COG1959	2 iron, 2 sulfur cluster binding
DNA52_RS13520	COG0028	Belongs to the TPP enzyme family
DNA52_RS13535	COG0235	Class ii aldolase
DNA52_RS13540	COG4806	L-rhamnose isomerase
DNA52_RS13545	COG3254	rhamnose metabolic process
DNA52_RS13550	COG1070	Carbohydrate kinase
DNA52_RS13555	COG2814	Major facilitator Superfamily
DNA52_RS13560	COG2207	Transcriptional regulator
DNA52_RS13565	COG1349	DNA-binding transcription factor activity
DNA52_RS13650	COG2207	Transcriptional regulator
DNA52_RS13650	COG1609	Transcriptional regulator
DNA52_RS13695	COG2723	6-phospho-beta-galactosidase activity
DNA52_RS13700	COG1940	carbohydrate kinase activity
DNA52_RS13705	COG0383	alpha-mannosidase activity
DNA52_RS13715	COG2188	Transcriptional regulator
DNA52_RS13725	COG3842	ATPase activity
DNA52_RS13735	COG4753	response regulator
DNA52_RS13735	COG2207	Transcriptional regulator
DNA52_RS13740	COG2972	Histidine kinase
DNA52_RS13750	COG0366	Alpha amylase catalytic
DNA52_RS13755	COG1653	transport
DNA52_RS13760	COG0395	ABC-type sugar transport system, permease component
DNA52_RS13775	COG2207	Transcriptional regulator
DNA52_RS13775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNA52_RS13780	COG1132	(ABC) transporter
DNA52_RS13785	COG1132	(ABC) transporter
DNA52_RS13790	COG2188	Transcriptional regulator
DNA52_RS13805	COG3732	PTS system glucitol sorbitol-specific
DNA52_RS13810	COG3730	PTS system glucitol sorbitol-specific
DNA52_RS13830	COG4975	Glucose uptake
DNA52_RS13835	COG1869	D-ribose catabolic process
DNA52_RS13845	COG1609	Transcriptional regulator
DNA52_RS13850	COG1012	belongs to the aldehyde dehydrogenase family
DNA52_RS13850	COG1454	alcohol dehydrogenase
DNA52_RS13860	COG1695	Transcriptional regulator
DNA52_RS13865	COG3479	Phenolic acid decarboxylase
DNA52_RS13880	COG1307	EDD domain protein, DegV family
DNA52_RS13920	COG0445	tRNA wobble uridine modification
DNA52_RS13925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DNA52_RS13930	COG1847	R3H domain protein
DNA52_RS13940	COG4166	transmembrane transport
DNA52_RS13945	COG0706	membrane insertase activity
DNA52_RS13950	COG0594	ribonuclease P activity
DNA52_RS13955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DNA52_RS13960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DNA52_RS13965	COG0592	DNA-directed DNA polymerase activity
DNA52_RS13970	COG2501	S4 domain
DNA52_RS13975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DNA52_RS13980	COG0187	DNA topoisomerase II activity
DNA52_RS13990	COG0360	Binds together with S18 to 16S ribosomal RNA
DNA52_RS13995	COG0629	single-stranded DNA binding
DNA52_RS14000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DNA52_RS14010	COG0359	binds to the 23S rRNA
DNA52_RS14015	COG0305	Participates in initiation and elongation during chromosome replication
DNA52_RS14025	COG2814	Major facilitator Superfamily
DNA52_RS14030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DNA52_RS14035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DNA52_RS14040	COG4166	transmembrane transport
DNA52_RS14050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DNA52_RS14055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DNA52_RS14060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DNA52_RS14065	COG0297	glycogen (starch) synthase activity
DNA52_RS14070	COG0058	SHG alpha-glucan phosphorylase activity
DNA52_RS14075	COG3103	Sh3 type 3 domain protein
DNA52_RS14075	COG0366	Alpha amylase catalytic
DNA52_RS14085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNA52_RS14090	COG1554	hydrolase, family 65, central catalytic
DNA52_RS14100	COG1278	Cold shock
DNA52_RS14115	COG0745	RESPONSE REGULATOR receiver
DNA52_RS14120	COG5002	protein histidine kinase activity
DNA52_RS14130	COG4853	Protein conserved in bacteria
DNA52_RS14135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DNA52_RS14140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNA52_RS14145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DNA52_RS14155	COG1012	belongs to the aldehyde dehydrogenase family
DNA52_RS14165	COG1573	uracil-dna glycosylase
DNA52_RS14185	COG3976	FMN-binding domain protein
DNA52_RS14185	COG0431	NADPH-dependent FMN reductase
DNA52_RS14185	COG1053	succinate dehydrogenase
DNA52_RS14190	COG0471	metal ion transport
DNA52_RS14205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNA52_RS14210	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS14220	COG0778	Nitroreductase
DNA52_RS14225	COG2508	Transcriptional regulator
DNA52_RS14235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNA52_RS14240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DNA52_RS14250	COG2365	Tyrosine phosphatase family
DNA52_RS14255	COG2368	4-hydroxyphenylacetate
DNA52_RS14275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DNA52_RS14310	COG0604	alcohol dehydrogenase
DNA52_RS14335	COG2267	carboxylic ester hydrolase activity
DNA52_RS14340	COG3022	response to hydroperoxide
DNA52_RS14350	COG4166	transmembrane transport
DNA52_RS14375	COG1122	ATPase activity
DNA52_RS14380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DNA52_RS14385	COG0310	cobalt ion transport
DNA52_RS14390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNA52_RS14395	COG3875	lactate racemase activity
DNA52_RS14400	COG1691	(AIR) carboxylase
DNA52_RS14405	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DNA52_RS14410	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DNA52_RS14415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNA52_RS14420	COG1606	tRNA processing
DNA52_RS14430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DNA52_RS14435	COG0351	phosphomethylpyrimidine kinase
DNA52_RS14440	COG0352	thiamine-phosphate diphosphorylase activity
DNA52_RS14450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DNA52_RS14465	COG1113	amino acid transport
DNA52_RS14475	COG2267	carboxylic ester hydrolase activity
DNA52_RS14480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DNA52_RS14495	COG1983	PspC domain protein
DNA52_RS14540	COG2807	transmembrane transport
DNA52_RS14545	COG0656	L-ascorbic acid biosynthetic process
DNA52_RS14550	COG0667	Aldo Keto reductase
DNA52_RS14580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DNA52_RS14585	COG1122	ATPase activity
DNA52_RS14590	COG4720	Psort location CytoplasmicMembrane, score
DNA52_RS14595	COG2188	Transcriptional regulator
DNA52_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
DNA52_RS14625	COG1131	(ABC) transporter
DNA52_RS14640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DNA52_RS14645	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DNA52_RS14650	COG1309	transcriptional regulator
DNA52_RS14655	COG2376	Dihydroxyacetone kinase
DNA52_RS14660	COG2376	Dihydroxyacetone kinase
DNA52_RS14665	COG1461	Dihydroxyacetone kinase
DNA52_RS14670	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DNA52_RS14675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNA52_RS14680	COG1609	Transcriptional regulator
DNA52_RS14685	COG1609	Transcriptional regulator
DNA52_RS14690	COG0366	Alpha amylase catalytic
DNA52_RS14695	COG2182	Extracellular solute-binding protein
DNA52_RS14700	COG1175	transmembrane transport
DNA52_RS14705	COG3833	ABC-type maltose transport systems, permease component
DNA52_RS14715	COG0366	Alpha amylase catalytic
DNA52_RS14720	COG3842	ATPase activity
DNA52_RS14770	COG1757	Na H antiporter
DNA52_RS14795	COG4166	transmembrane transport
DNA52_RS14800	COG4166	transmembrane transport
DNA52_RS14810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNA52_RS14815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DNA52_RS14820	COG0406	alpha-ribazole phosphatase activity
DNA52_RS14825	COG0667	Aldo Keto reductase
DNA52_RS14855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNA52_RS14860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNA52_RS14865	COG0488	(ABC) transporter
DNA52_RS14875	COG4172	Belongs to the ABC transporter superfamily
DNA52_RS14885	COG0386	Belongs to the glutathione peroxidase family
DNA52_RS14895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DNA52_RS14910	COG0363	glucosamine-6-phosphate deaminase activity
DNA52_RS14920	COG1053	succinate dehydrogenase
DNA52_RS14935	COG2213	PTS system mannitol-specific
DNA52_RS14945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNA52_RS14950	COG0246	Mannitol dehydrogenase
DNA52_RS14960	COG3118	belongs to the thioredoxin family
DNA52_RS14990	COG0431	NADPH-dependent FMN reductase
DNA52_RS14995	COG2188	Transcriptional regulator
DNA52_RS15000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS15015	COG3964	amidohydrolase
DNA52_RS15035	COG1045	serine acetyltransferase
DNA52_RS15040	COG0626	cystathionine gamma-synthase activity
DNA52_RS15045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DNA52_RS15075	COG2188	Transcriptional regulator
DNA52_RS15080	COG0366	Alpha amylase catalytic
DNA52_RS15085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS15085	COG1263	PTS System
DNA52_RS15085	COG2190	(PTS) system
DNA52_RS15090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNA52_RS15090	COG2190	(PTS) system
DNA52_RS15090	COG1263	PTS System
DNA52_RS15100	COG0163	prenyltransferase activity
DNA52_RS15110	COG1959	2 iron, 2 sulfur cluster binding
DNA52_RS15115	COG1309	transcriptional regulator
DNA52_RS15120	COG1914	H( )-stimulated, divalent metal cation uptake system
DNA52_RS15140	COG2814	Major facilitator Superfamily
DNA52_RS15150	COG5002	protein histidine kinase activity
DNA52_RS15155	COG0745	RESPONSE REGULATOR receiver
DNA52_RS15165	COG1737	Transcriptional regulator
DNA52_RS15170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNA52_RS15185	COG1316	TRANSCRIPTIONal
DNA52_RS15190	COG0277	FAD linked oxidase domain protein
DNA52_RS15200	COG2357	RelA SpoT domain protein
DNA52_RS15210	COG1033	growth of symbiont in host cell
DNA52_RS15210	COG2409	Drug exporters of the RND superfamily
DNA52_RS15215	COG2818	Glycosylase
DNA52_RS15225	COG0577	efflux transmembrane transporter activity
DNA52_RS15230	COG1136	(ABC) transporter
DNA52_RS15245	COG0741	lytic transglycosylase activity
DNA52_RS15250	COG1388	LysM domain
DNA52_RS15250	COG3942	CHAP domain
DNA52_RS15280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DNA52_RS15290	COG1846	Transcriptional regulator
DNA52_RS15295	COG1252	NADH dehydrogenase
DNA52_RS15335	COG3842	ATPase activity
DNA52_RS15365	COG1725	Transcriptional regulator
DNA52_RS15370	COG1131	(ABC) transporter
DNA52_RS15380	COG1012	belongs to the aldehyde dehydrogenase family
DNA52_RS15380	COG1454	alcohol dehydrogenase
DNA52_RS15420	COG1268	BioY protein
DNA52_RS15435	COG0436	Aminotransferase
DNA52_RS15445	COG1682	transport, permease protein
DNA52_RS15450	COG1134	teichoic acid transport
DNA52_RS15465	COG2814	Major facilitator Superfamily
DNA52_RS15470	COG0004	ammonium transporteR
DNA52_RS15490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DNA52_RS15500	COG3759	membrane
DNA52_RS15505	COG1881	PFAM PEBP family protein
DNA52_RS15535	COG0300	oxidoreductase activity
DNA52_RS15545	COG0328	RNA-DNA hybrid ribonuclease activity
DNA52_RS15555	COG1125	glycine betaine transport
DNA52_RS15565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNA52_RS15575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family