locus-tag	class	description
C7M40_RS00050	COG3728	DNA packaging
C7M40_RS00050	COG5484	DNA packaging
C7M40_RS00065	COG2868	ribosomal protein
C7M40_RS00195	COG0726	polysaccharide deacetylase
C7M40_RS00210	COG1132	(ABC) transporter
C7M40_RS00225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7M40_RS00235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7M40_RS00240	COG1482	cell wall glycoprotein biosynthetic process
C7M40_RS00245	COG3442	glutamine amidotransferase
C7M40_RS00250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7M40_RS00255	COG1435	thymidine kinase activity
C7M40_RS00260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7M40_RS00265	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M40_RS00270	COG0009	L-threonylcarbamoyladenylate synthase
C7M40_RS00275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7M40_RS00280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7M40_RS00290	COG2233	PERMEase
C7M40_RS00295	COG0356	it plays a direct role in the translocation of protons across the membrane
C7M40_RS00300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M40_RS00305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7M40_RS00310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M40_RS00315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7M40_RS00320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7M40_RS00325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7M40_RS00330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7M40_RS00335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M40_RS00340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M40_RS00345	COG1077	Cell shape determining protein MreB Mrl
C7M40_RS00350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7M40_RS00360	COG0772	Belongs to the SEDS family
C7M40_RS00365	COG0509	glycine decarboxylation via glycine cleavage system
C7M40_RS00370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7M40_RS00375	COG2011	ABC-type metal ion transport system permease component
C7M40_RS00380	COG1464	Belongs to the NlpA lipoprotein family
C7M40_RS00400	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M40_RS00420	COG0589	response to stress
C7M40_RS00435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7M40_RS00440	COG2918	glutathione biosynthetic process
C7M40_RS00440	COG0189	ligase activity
C7M40_RS00445	COG0640	Transcriptional regulator
C7M40_RS00460	COG4493	Belongs to the UPF0637 family
C7M40_RS00465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7M40_RS00470	COG1956	GAF domain-containing protein
C7M40_RS00475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7M40_RS00480	COG1104	cysteine desulfurase activity
C7M40_RS00485	COG0301	tRNA thio-modification
C7M40_RS00490	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M40_RS00490	COG2918	glutathione biosynthetic process
C7M40_RS00500	COG0525	valine-tRNA ligase activity
C7M40_RS00505	COG0285	dihydrofolate synthase activity
C7M40_RS00510	COG2003	Belongs to the UPF0758 family
C7M40_RS00515	COG1077	Cell shape determining protein MreB Mrl
C7M40_RS00520	COG1792	Involved in formation and maintenance of cell shape
C7M40_RS00530	COG0850	regulation of cytokinetic process
C7M40_RS00535	COG2894	cell division
C7M40_RS00540	COG0765	amino acid transport
C7M40_RS00545	COG1126	abc transporter atp-binding protein
C7M40_RS00550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M40_RS00560	COG0527	aspartate kinase activity
C7M40_RS00565	COG0612	Peptidase, M16
C7M40_RS00570	COG0612	Peptidase, M16
C7M40_RS00575	COG1426	Protein conserved in bacteria
C7M40_RS00580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7M40_RS00585	COG1546	Belongs to the CinA family
C7M40_RS00585	COG1058	Belongs to the CinA family
C7M40_RS00590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7M40_RS00595	COG1418	mRNA catabolic process
C7M40_RS00600	COG1692	metallophosphoesterase
C7M40_RS00605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7M40_RS00610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7M40_RS00635	COG0632	four-way junction helicase activity
C7M40_RS00640	COG2255	four-way junction helicase activity
C7M40_RS00645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7M40_RS00650	COG0343	queuine tRNA-ribosyltransferase activity
C7M40_RS00655	COG1862	Preprotein translocase
C7M40_RS00660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M40_RS00665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7M40_RS00670	COG0513	Belongs to the DEAD box helicase family
C7M40_RS00675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7M40_RS00680	COG4472	Bacterial protein of unknown function (DUF965)
C7M40_RS00685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7M40_RS00690	COG3906	Belongs to the UPF0473 family
C7M40_RS00700	COG1193	negative regulation of DNA recombination
C7M40_RS00705	COG3118	belongs to the thioredoxin family
C7M40_RS00710	COG1719	4-vinyl reductase, 4VR
C7M40_RS00715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7M40_RS00720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7M40_RS00730	COG0517	IMP dehydrogenase activity
C7M40_RS00735	COG2171	N-acyltransferase activity
C7M40_RS00740	COG1473	amidohydrolase
C7M40_RS00745	COG0668	transmembrane transport
C7M40_RS00760	COG0789	Transcriptional regulator
C7M40_RS00765	COG0006	proline dipeptidase activity
C7M40_RS00770	COG1609	Transcriptional regulator
C7M40_RS00785	COG0217	transcriptional regulatory protein
C7M40_RS00795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7M40_RS00825	COG0827	DNA restriction-modification system
C7M40_RS00830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7M40_RS00835	COG1113	amino acid transport
C7M40_RS00845	COG0737	Belongs to the 5'-nucleotidase family
C7M40_RS00850	COG4470	Protein conserved in bacteria
C7M40_RS00855	COG0647	UMP catabolic process
C7M40_RS00865	COG0586	Pfam SNARE associated Golgi protein
C7M40_RS00875	COG1098	S1 RNA binding domain
C7M40_RS01015	COG1234	tRNA 3'-trailer cleavage
C7M40_RS01020	COG1393	Belongs to the ArsC family
C7M40_RS01025	COG4862	establishment of competence for transformation
C7M40_RS01035	COG1164	Oligoendopeptidase f
C7M40_RS01045	COG2357	RelA SpoT domain protein
C7M40_RS01050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7M40_RS01055	COG0564	pseudouridine synthase activity
C7M40_RS01060	COG3142	Participates in the control of copper homeostasis
C7M40_RS01065	COG2706	6-phosphogluconolactonase activity
C7M40_RS01075	COG0628	permease
C7M40_RS01080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7M40_RS01090	COG1114	Component of the transport system for branched-chain amino acids
C7M40_RS01100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7M40_RS01105	COG1674	ftsk spoiiie
C7M40_RS01125	COG2001	Belongs to the MraZ family
C7M40_RS01130	COG0275	rRNA processing
C7M40_RS01145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7M40_RS01150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7M40_RS01155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7M40_RS01160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7M40_RS01175	COG1799	cell septum assembly
C7M40_RS01180	COG0762	integral membrane protein
C7M40_RS01190	COG3599	regulation of cell shape
C7M40_RS01195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7M40_RS01200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7M40_RS01205	COG0494	nUDIX hydrolase
C7M40_RS01215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7M40_RS01220	COG1104	cysteine desulfurase activity
C7M40_RS01230	COG0482	sulfurtransferase activity
C7M40_RS01235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7M40_RS01240	COG0569	domain protein
C7M40_RS01270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7M40_RS01275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7M40_RS01280	COG1388	LysM domain
C7M40_RS01280	COG3584	3D domain protein
C7M40_RS01290	COG1597	lipid kinase activity
C7M40_RS01295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C7M40_RS01310	COG0242	peptide deformylase activity
C7M40_RS01335	COG0039	L-malate dehydrogenase activity
C7M40_RS01340	COG4476	Belongs to the UPF0223 family
C7M40_RS01345	COG0483	inositol monophosphate 1-phosphatase activity
C7M40_RS01365	COG0772	Belongs to the SEDS family
C7M40_RS01370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C7M40_RS01375	COG4471	UPF0298 protein
C7M40_RS01380	COG0742	ribosomal rna small subunit methyltransferase
C7M40_RS01385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7M40_RS01390	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7M40_RS01400	COG2131	deaminase
C7M40_RS01405	COG2333	competence protein COMEC
C7M40_RS01405	COG0658	competence protein
C7M40_RS01410	COG1466	dna polymerase III delta subunit
C7M40_RS01415	COG0268	Binds directly to 16S ribosomal RNA
C7M40_RS01420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7M40_RS01445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7M40_RS01450	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7M40_RS01455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7M40_RS01460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7M40_RS01480	COG0765	amino acid transport
C7M40_RS01485	COG1126	abc transporter atp-binding protein
C7M40_RS01490	COG0322	excinuclease ABC activity
C7M40_RS01500	COG0489	protein tyrosine kinase activity
C7M40_RS01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M40_RS01515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M40_RS01520	COG0297	glycogen (starch) synthase activity
C7M40_RS01545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C7M40_RS01550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS01550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M40_RS01550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS01555	COG1105	Belongs to the carbohydrate kinase PfkB family
C7M40_RS01560	COG1349	DNA-binding transcription factor activity
C7M40_RS01565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7M40_RS01575	COG1234	tRNA 3'-trailer cleavage
C7M40_RS01580	COG0300	oxidoreductase activity
C7M40_RS01585	COG5416	Lipopolysaccharide assembly protein A domain
C7M40_RS01590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7M40_RS01590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7M40_RS01595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M40_RS01610	COG0393	Putative heavy-metal-binding
C7M40_RS01630	COG0772	Belongs to the SEDS family
C7M40_RS01640	COG1116	anion transmembrane transporter activity
C7M40_RS01645	COG1316	TRANSCRIPTIONal
C7M40_RS01655	COG0463	Glycosyl transferase, family 2
C7M40_RS01670	COG3425	synthase
C7M40_RS01685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7M40_RS01690	COG4224	UPF0291 protein
C7M40_RS01695	COG3763	UPF0154 protein
C7M40_RS01700	COG0204	Acyl-transferase
C7M40_RS01705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7M40_RS01710	COG2827	Endonuclease containing a URI domain
C7M40_RS01715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M40_RS01725	COG0052	Belongs to the universal ribosomal protein uS2 family
C7M40_RS01730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7M40_RS01735	COG0528	UMP kinase activity
C7M40_RS01740	COG0233	cytoplasmic translational termination
C7M40_RS01745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7M40_RS01750	COG4589	Belongs to the CDS family
C7M40_RS01755	COG0750	zinc metalloprotease
C7M40_RS01760	COG0442	prolyl-tRNA aminoacylation
C7M40_RS01765	COG2176	DNA-directed DNA polymerase activity
C7M40_RS01770	COG0779	Required for maturation of 30S ribosomal subunits
C7M40_RS01775	COG0195	Participates in both transcription termination and antitermination
C7M40_RS01780	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7M40_RS01790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7M40_RS01795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7M40_RS01800	COG0738	Major facilitator superfamily
C7M40_RS01805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7M40_RS01815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7M40_RS01820	COG0287	Prephenate dehydrogenase
C7M40_RS01825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7M40_RS01830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7M40_RS01835	COG0196	riboflavin kinase activity
C7M40_RS01840	COG3527	Alpha-acetolactate decarboxylase
C7M40_RS01845	COG1420	regulation of RNA biosynthetic process
C7M40_RS01850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7M40_RS01855	COG0443	Heat shock 70 kDa protein
C7M40_RS01860	COG0484	heat shock protein binding
C7M40_RS01865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7M40_RS01875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7M40_RS01880	COG1696	Membrane protein involved in D-alanine export
C7M40_RS01885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M40_RS01890	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C7M40_RS01895	COG0481	GTPase activity
C7M40_RS01910	COG2094	Belongs to the DNA glycosylase MPG family
C7M40_RS01915	COG2264	protein methyltransferase activity
C7M40_RS01920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7M40_RS01930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7M40_RS01935	COG1490	D-aminoacyl-tRNA deacylase activity
C7M40_RS01940	COG0546	phosphoglycolate phosphatase activity
C7M40_RS01950	COG3103	Sh3 type 3 domain protein
C7M40_RS01950	COG4991	sh3 domain protein
C7M40_RS01950	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7M40_RS01955	COG0124	histidyl-tRNA synthetase
C7M40_RS01960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7M40_RS01970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7M40_RS01980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7M40_RS01990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7M40_RS01995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7M40_RS02000	COG1610	YqeY-like protein
C7M40_RS02005	COG1702	phosphate starvation-inducible protein PhoH
C7M40_RS02010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7M40_RS02015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7M40_RS02020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7M40_RS02025	COG1381	Involved in DNA repair and RecF pathway recombination
C7M40_RS02030	COG0752	glycyl-tRNA synthetase alpha subunit
C7M40_RS02035	COG0751	glycine-tRNA ligase activity
C7M40_RS02040	COG0358	DNA primase activity
C7M40_RS02045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7M40_RS02050	COG1725	Transcriptional regulator
C7M40_RS02055	COG1131	(ABC) transporter
C7M40_RS02075	COG1131	(ABC) transporter
C7M40_RS02090	COG0519	Catalyzes the synthesis of GMP from XMP
C7M40_RS02100	COG1131	(ABC) transporter
C7M40_RS02110	COG4585	Histidine kinase
C7M40_RS02115	COG2197	response regulator
C7M40_RS02120	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS02130	COG0604	alcohol dehydrogenase
C7M40_RS02135	COG0583	DNA-binding transcription factor activity
C7M40_RS02165	COG0546	phosphoglycolate phosphatase activity
C7M40_RS02185	COG1393	Belongs to the ArsC family
C7M40_RS02195	COG1349	DNA-binding transcription factor activity
C7M40_RS02200	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS02205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M40_RS02215	COG0477	Major facilitator Superfamily
C7M40_RS02220	COG0148	phosphopyruvate hydratase activity
C7M40_RS02225	COG2217	Heavy metal translocating P-type atpase
C7M40_RS02245	COG1846	Transcriptional regulator
C7M40_RS02255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7M40_RS02255	COG0574	Belongs to the PEP-utilizing enzyme family
C7M40_RS02280	COG2384	SAM-dependent methyltransferase
C7M40_RS02285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7M40_RS02295	COG0542	response to heat
C7M40_RS02305	COG0587	DNA-directed DNA polymerase activity
C7M40_RS02310	COG0205	6-phosphofructokinase activity
C7M40_RS02325	COG2996	Protein conserved in bacteria
C7M40_RS02330	COG4974	Belongs to the 'phage' integrase family
C7M40_RS02340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7M40_RS02345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7M40_RS02350	COG1187	pseudouridine synthase activity
C7M40_RS02355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7M40_RS02365	COG0514	ATP-dependent DNA helicase (RecQ)
C7M40_RS02375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7M40_RS02380	COG0539	negative regulation of cytoplasmic translation
C7M40_RS02385	COG1160	GTP binding
C7M40_RS02400	COG0457	Tetratricopeptide repeat
C7M40_RS02405	COG0561	phosphatase activity
C7M40_RS02410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7M40_RS02415	COG0617	tRNA 3'-terminal CCA addition
C7M40_RS02425	COG0488	(ABC) transporter
C7M40_RS02430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7M40_RS02435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7M40_RS02440	COG1307	EDD domain protein, DegV family
C7M40_RS02445	COG2755	lipolytic protein G-D-S-L family
C7M40_RS02450	COG4698	Protein conserved in bacteria
C7M40_RS02455	COG4479	Belongs to the UPF0346 family
C7M40_RS02460	COG0793	Belongs to the peptidase S41A family
C7M40_RS02460	COG3409	Peptidoglycan-binding domain 1 protein
C7M40_RS02465	COG2814	Major facilitator Superfamily
C7M40_RS02485	COG0583	DNA-binding transcription factor activity
C7M40_RS02490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M40_RS02495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7M40_RS02500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7M40_RS02505	COG0758	DNA mediated transformation
C7M40_RS02510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7M40_RS02515	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C7M40_RS02520	COG4974	Belongs to the 'phage' integrase family
C7M40_RS02525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7M40_RS02530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7M40_RS02540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7M40_RS02545	COG0187	DNA topoisomerase II activity
C7M40_RS02555	COG0583	DNA-binding transcription factor activity
C7M40_RS02560	COG1227	inorganic diphosphatase activity
C7M40_RS02565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M40_RS02605	COG1846	Transcriptional regulator
C7M40_RS02630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7M40_RS02640	COG1620	l-lactate permease
C7M40_RS02655	COG1113	amino acid transport
C7M40_RS02710	COG1307	EDD domain protein, DegV family
C7M40_RS02725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C7M40_RS02730	COG1131	(ABC) transporter
C7M40_RS02755	COG5646	InterPro IPR014922
C7M40_RS02770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7M40_RS02775	COG0505	Belongs to the CarA family
C7M40_RS02780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7M40_RS02785	COG0564	pseudouridine synthase activity
C7M40_RS02790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7M40_RS02795	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7M40_RS02810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M40_RS02835	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7M40_RS02855	COG1216	Glycosyl transferase, family 2
C7M40_RS02865	COG1073	alpha beta
C7M40_RS02870	COG0477	Major facilitator Superfamily
C7M40_RS02880	COG0116	Belongs to the methyltransferase superfamily
C7M40_RS02890	COG3599	regulation of cell shape
C7M40_RS02895	COG4474	Belongs to the UPF0398 family
C7M40_RS02900	COG3331	DNA recombination
C7M40_RS02915	COG1840	ABC-type Fe3 transport system, periplasmic component
C7M40_RS02920	COG1177	transmembrane transport
C7M40_RS02930	COG1464	Belongs to the NlpA lipoprotein family
C7M40_RS02935	COG2011	ABC-type metal ion transport system permease component
C7M40_RS02940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7M40_RS02955	COG0017	Asparaginyl-tRNA synthetase
C7M40_RS02970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7M40_RS02970	COG1199	ATP-dependent helicase activity
C7M40_RS02995	COG1304	FMN binding
C7M40_RS03000	COG2017	converts alpha-aldose to the beta-anomer
C7M40_RS03020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C7M40_RS03020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7M40_RS03025	COG0561	phosphatase activity
C7M40_RS03030	COG0531	amino acid
C7M40_RS03065	COG1942	4-Oxalocrotonate Tautomerase
C7M40_RS03080	COG3237	CsbD-like
C7M40_RS03085	COG2261	transglycosylase associated protein
C7M40_RS03100	COG1597	lipid kinase activity
C7M40_RS03105	COG3152	Membrane
C7M40_RS03115	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7M40_RS03130	COG3397	chitin binding
C7M40_RS03135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7M40_RS03155	COG0477	Major facilitator Superfamily
C7M40_RS03165	COG1162	GTPase activity
C7M40_RS03170	COG1607	acyl-coa hydrolase
C7M40_RS03175	COG0583	DNA-binding transcription factor activity
C7M40_RS03180	COG1811	Na channel or pump
C7M40_RS03190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7M40_RS03205	COG0439	Biotin carboxylase
C7M40_RS03220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7M40_RS03225	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS03230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7M40_RS03235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M40_RS03240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M40_RS03245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7M40_RS03255	COG0300	oxidoreductase activity
C7M40_RS03265	COG1063	alcohol dehydrogenase
C7M40_RS03285	COG0159	tryptophan synthase activity
C7M40_RS03290	COG0133	tryptophan synthase activity
C7M40_RS03295	COG0135	phosphoribosylanthranilate isomerase activity
C7M40_RS03300	COG0134	indole-3-glycerol-phosphate synthase activity
C7M40_RS03305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7M40_RS03310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7M40_RS03310	COG0512	Glutamine amidotransferase of anthranilate synthase
C7M40_RS03325	COG1131	(ABC) transporter
C7M40_RS03345	COG0335	large ribosomal subunit rRNA binding
C7M40_RS03350	COG0336	Belongs to the RNA methyltransferase TrmD family
C7M40_RS03355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7M40_RS03360	COG1837	Belongs to the UPF0109 family
C7M40_RS03365	COG0228	four-way junction DNA binding
C7M40_RS03370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7M40_RS03375	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C7M40_RS03380	COG0552	protein localization to endoplasmic reticulum
C7M40_RS03385	COG1196	nuclear chromosome segregation
C7M40_RS03390	COG0571	ribonuclease III activity
C7M40_RS03395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M40_RS03400	COG0416	fatty acid biosynthetic process
C7M40_RS03405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7M40_RS03410	COG1461	Dihydroxyacetone kinase
C7M40_RS03415	COG1302	Protein conserved in bacteria
C7M40_RS03420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7M40_RS03430	COG1564	THIamine pyrophosphokinase
C7M40_RS03435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7M40_RS03440	COG1162	GTPase activity
C7M40_RS03445	COG0515	serine threonine protein kinase
C7M40_RS03445	COG2815	serine threonine protein kinase
C7M40_RS03450	COG0631	protein serine/threonine phosphatase activity
C7M40_RS03455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7M40_RS03455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7M40_RS03460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7M40_RS03465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7M40_RS03470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7M40_RS03475	COG1758	RNA polymerase activity
C7M40_RS03480	COG0194	GDP metabolic process
C7M40_RS03490	COG1174	glycine betaine transport
C7M40_RS03495	COG1732	Glycine betaine
C7M40_RS03510	COG0497	DNA recombination
C7M40_RS03515	COG1438	arginine binding
C7M40_RS03520	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7M40_RS03525	COG0142	geranyltranstransferase activity
C7M40_RS03530	COG1722	exodeoxyribonuclease VII activity
C7M40_RS03535	COG1570	exodeoxyribonuclease VII activity
C7M40_RS03540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7M40_RS03545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7M40_RS03550	COG1302	Protein conserved in bacteria
C7M40_RS03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7M40_RS03560	COG0006	proline dipeptidase activity
C7M40_RS03565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7M40_RS03575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7M40_RS03625	COG0789	Transcriptional regulator
C7M40_RS03630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7M40_RS03635	COG0584	glycerophosphoryl diester phosphodiesterase
C7M40_RS03655	COG1940	carbohydrate kinase activity
C7M40_RS03665	COG0457	Tetratricopeptide repeat
C7M40_RS03665	COG0705	Rhomboid family
C7M40_RS03670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7M40_RS03675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M40_RS03680	COG0768	penicillin binding
C7M40_RS03690	COG4841	protein insertion into membrane
C7M40_RS03705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7M40_RS03710	COG0572	uridine kinase
C7M40_RS03715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7M40_RS03720	COG0072	phenylalanine-tRNA ligase activity
C7M40_RS03720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M40_RS03725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7M40_RS03730	COG1733	regulation of RNA biosynthetic process
C7M40_RS03740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M40_RS03745	COG1254	Belongs to the acylphosphatase family
C7M40_RS03750	COG0706	membrane insertase activity
C7M40_RS03765	COG0419	ATPase involved in DNA repair
C7M40_RS03775	COG5002	protein histidine kinase activity
C7M40_RS03780	COG0745	RESPONSE REGULATOR receiver
C7M40_RS03785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7M40_RS03790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7M40_RS03805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7M40_RS03815	COG1323	Belongs to the UPF0348 family
C7M40_RS03820	COG2226	methyltransferase
C7M40_RS03825	COG0799	negative regulation of ribosome biogenesis
C7M40_RS03830	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7M40_RS03835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7M40_RS03840	COG1534	Rna-binding protein
C7M40_RS03845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7M40_RS03860	COG1215	transferase activity, transferring glycosyl groups
C7M40_RS03870	COG1733	regulation of RNA biosynthetic process
C7M40_RS03875	COG0604	alcohol dehydrogenase
C7M40_RS03880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7M40_RS03890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7M40_RS03895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7M40_RS03900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7M40_RS03905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7M40_RS03910	COG1484	DNA-dependent DNA replication
C7M40_RS03915	COG3611	Membrane attachment protein
C7M40_RS03920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7M40_RS03925	COG0237	dephospho-CoA kinase activity
C7M40_RS03930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7M40_RS03935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7M40_RS03935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7M40_RS03945	COG3655	Transcriptional regulator
C7M40_RS03965	COG2181	nitrate reductase activity
C7M40_RS03975	COG1140	nitrate reductase beta subunit
C7M40_RS03980	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C7M40_RS03985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7M40_RS03995	COG0303	'Molybdopterin
C7M40_RS04000	COG1763	Mo-molybdopterin cofactor biosynthetic process
C7M40_RS04005	COG0315	cyclic pyranopterin monophosphate synthase activity
C7M40_RS04030	COG2197	response regulator
C7M40_RS04055	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M40_RS04060	COG2223	nitrite transmembrane transporter activity
C7M40_RS04065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7M40_RS04080	COG0716	FMN binding
C7M40_RS04090	COG1120	ATPase activity
C7M40_RS04100	COG0719	Fe-S assembly protein
C7M40_RS04110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7M40_RS04115	COG0719	Fe-S assembly protein
C7M40_RS04140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7M40_RS04145	COG1674	ftsk spoiiie
C7M40_RS04150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M40_RS04160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7M40_RS04165	COG0510	thiamine kinase activity
C7M40_RS04170	COG4473	ABC transporter
C7M40_RS04175	COG1131	(ABC) transporter
C7M40_RS04180	COG0537	adenosine 5'-monophosphoramidase activity
C7M40_RS04190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7M40_RS04220	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS04230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M40_RS04245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7M40_RS04250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M40_RS04250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M40_RS04255	COG0307	riboflavin synthase, alpha
C7M40_RS04260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7M40_RS04260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7M40_RS04280	COG0463	Glycosyl transferase, family 2
C7M40_RS04285	COG0586	Pfam SNARE associated Golgi protein
C7M40_RS04290	COG0463	Glycosyl transferase, family 2
C7M40_RS04300	COG0745	RESPONSE REGULATOR receiver
C7M40_RS04305	COG3850	Histidine kinase
C7M40_RS04305	COG5002	protein histidine kinase activity
C7M40_RS04320	COG3976	FMN-binding domain protein
C7M40_RS04320	COG1053	succinate dehydrogenase
C7M40_RS04320	COG0431	NADPH-dependent FMN reductase
C7M40_RS04330	COG0583	DNA-binding transcription factor activity
C7M40_RS04345	COG3481	metal-dependent phosphohydrolase, HD sub domain
C7M40_RS04350	COG4717	serine-type aminopeptidase activity
C7M40_RS04355	COG0420	3'-5' exonuclease activity
C7M40_RS04360	COG3679	Belongs to the UPF0342 family
C7M40_RS04365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7M40_RS04375	COG1438	arginine binding
C7M40_RS04380	COG0436	Aminotransferase
C7M40_RS04390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M40_RS04395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M40_RS04400	COG1376	ErfK ybiS ycfS ynhG family protein
C7M40_RS04415	COG1136	(ABC) transporter
C7M40_RS04415	COG0577	efflux transmembrane transporter activity
C7M40_RS04425	COG0018	arginyl-trna synthetase
C7M40_RS04430	COG2153	protein acetylation
C7M40_RS04450	COG0534	Mate efflux family protein
C7M40_RS04455	COG3273	potassium ion transport
C7M40_RS04455	COG0471	metal ion transport
C7M40_RS04465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7M40_RS04470	COG0529	Catalyzes the synthesis of activated sulfate
C7M40_RS04475	COG2046	Belongs to the sulfate adenylyltransferase family
C7M40_RS04485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M40_RS04490	COG0646	methionine synthase
C7M40_RS04490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7M40_RS04535	COG4372	Transposase
C7M40_RS04760	COG1396	sequence-specific DNA binding
C7M40_RS04820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M40_RS04835	COG1846	Transcriptional regulator
C7M40_RS04855	COG3279	Response regulator of the LytR AlgR family
C7M40_RS04875	COG0561	phosphatase activity
C7M40_RS04880	COG0697	spore germination
C7M40_RS04890	COG0789	Transcriptional regulator
C7M40_RS04895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M40_RS04925	COG1511	domain protein
C7M40_RS04925	COG1511	domain protein
C7M40_RS04930	COG1970	mechanosensitive ion channel activity
C7M40_RS04935	COG1428	Deoxynucleoside kinase
C7M40_RS04940	COG0584	glycerophosphoryl diester phosphodiesterase
C7M40_RS04950	COG0395	ABC-type sugar transport system, permease component
C7M40_RS04955	COG1175	transmembrane transport
C7M40_RS04960	COG3842	ATPase activity
C7M40_RS04970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M40_RS04975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7M40_RS04980	COG1187	pseudouridine synthase activity
C7M40_RS04985	COG2244	polysaccharide biosynthetic process
C7M40_RS04990	COG0495	leucyl-tRNA aminoacylation
C7M40_RS05000	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C7M40_RS05015	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS05030	COG0477	Major facilitator Superfamily
C7M40_RS05035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7M40_RS05045	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS05050	COG2040	homocysteine
C7M40_RS05055	COG0833	amino acid
C7M40_RS05070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7M40_RS05090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M40_RS05175	COG1368	sulfuric ester hydrolase activity
C7M40_RS05180	COG4703	Protein of unknown function (DUF1797)
C7M40_RS05185	COG0436	Aminotransferase
C7M40_RS05190	COG1686	Belongs to the peptidase S11 family
C7M40_RS05200	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS05205	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS05225	COG0542	response to heat
C7M40_RS05230	COG0582	viral genome integration into host DNA
C7M40_RS05240	COG4608	Belongs to the ABC transporter superfamily
C7M40_RS05245	COG0444	Belongs to the ABC transporter superfamily
C7M40_RS05250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M40_RS05255	COG0601	transmembrane transport
C7M40_RS05260	COG4166	transmembrane transport
C7M40_RS05290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7M40_RS05295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7M40_RS05300	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7M40_RS05305	COG1070	Carbohydrate kinase
C7M40_RS05310	COG2610	gluconate transmembrane transporter activity
C7M40_RS05315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7M40_RS05320	COG0628	permease
C7M40_RS05330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7M40_RS05350	COG3557	Belongs to the UPF0374 family
C7M40_RS05355	COG2137	regulation of response to DNA damage stimulus
C7M40_RS05395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M40_RS05420	COG1442	glycosyl transferase family 8
C7M40_RS05420	COG1216	Glycosyl transferase, family 2
C7M40_RS05460	COG2826	transposase and inactivated derivatives, IS30 family
C7M40_RS05465	COG2244	polysaccharide biosynthetic process
C7M40_RS05470	COG1091	dTDP-4-dehydrorhamnose reductase activity
C7M40_RS05475	COG1088	dTDP-glucose 4,6-dehydratase activity
C7M40_RS05485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C7M40_RS05495	COG0489	protein tyrosine kinase activity
C7M40_RS05515	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS05545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS05555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7M40_RS05565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7M40_RS05590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS05605	COG0513	Belongs to the DEAD box helicase family
C7M40_RS05610	COG0673	inositol 2-dehydrogenase activity
C7M40_RS05615	COG1278	Cold shock
C7M40_RS05630	COG1737	Transcriptional regulator
C7M40_RS05640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS05655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M40_RS05660	COG1597	lipid kinase activity
C7M40_RS05665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M40_RS05670	COG0154	amidase activity
C7M40_RS05675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M40_RS05680	COG4851	CamS sex pheromone cAM373 precursor
C7M40_RS05685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7M40_RS05695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7M40_RS05700	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C7M40_RS05705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M40_RS05710	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7M40_RS05725	COG0142	geranyltranstransferase activity
C7M40_RS05740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7M40_RS05745	COG4988	ABC transporter
C7M40_RS05750	COG1294	oxidase, subunit
C7M40_RS05755	COG1271	oxidase subunit
C7M40_RS05770	COG4684	Psort location CytoplasmicMembrane, score
C7M40_RS05775	COG0531	amino acid
C7M40_RS05785	COG0281	malic enzyme
C7M40_RS05790	COG0583	DNA-binding transcription factor activity
C7M40_RS05795	COG0583	DNA-binding transcription factor activity
C7M40_RS05805	COG1053	succinate dehydrogenase
C7M40_RS05810	COG0114	fumarate hydratase activity
C7M40_RS05835	COG2826	transposase and inactivated derivatives, IS30 family
C7M40_RS05850	COG3052	prosthetic group binding
C7M40_RS05870	COG0471	metal ion transport
C7M40_RS05875	COG0039	L-malate dehydrogenase activity
C7M40_RS05885	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7M40_RS05890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M40_RS05895	COG1121	(ABC) transporter
C7M40_RS05900	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C7M40_RS05905	COG1917	Cupin 2, conserved barrel domain protein
C7M40_RS05905	COG4977	sequence-specific DNA binding
C7M40_RS05910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C7M40_RS05920	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M40_RS05925	COG0471	metal ion transport
C7M40_RS05930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7M40_RS05935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7M40_RS05940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7M40_RS05945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7M40_RS05965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7M40_RS05970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7M40_RS05975	COG0101	tRNA pseudouridine synthase activity
C7M40_RS05985	COG1122	ATPase activity
C7M40_RS05990	COG1122	ATPase activity
C7M40_RS06000	COG4939	FMN-binding domain protein
C7M40_RS06025	COG0203	ribosomal protein L17
C7M40_RS06030	COG0202	RNA polymerase activity
C7M40_RS06035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7M40_RS06040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7M40_RS06045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7M40_RS06050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7M40_RS06055	COG0563	adenylate kinase activity
C7M40_RS06065	COG0200	Binds to the 23S rRNA
C7M40_RS06070	COG1841	ribosomal large subunit assembly
C7M40_RS06075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7M40_RS06080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7M40_RS06085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7M40_RS06090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7M40_RS06095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7M40_RS06100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7M40_RS06105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7M40_RS06110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7M40_RS06115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7M40_RS06120	COG0255	Belongs to the universal ribosomal protein uL29 family
C7M40_RS06125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7M40_RS06130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7M40_RS06135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7M40_RS06140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7M40_RS06145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7M40_RS06150	COG0089	rRNA binding
C7M40_RS06155	COG0088	Forms part of the polypeptide exit tunnel
C7M40_RS06160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7M40_RS06165	COG0051	transcription antitermination factor activity, RNA binding
C7M40_RS06170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7M40_RS06175	COG0049	tRNA binding
C7M40_RS06180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7M40_RS06185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7M40_RS06190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7M40_RS06195	COG0085	RNA polymerase activity
C7M40_RS06205	COG0542	response to heat
C7M40_RS06210	COG4463	regulation of RNA biosynthetic process
C7M40_RS06250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7M40_RS06255	COG1428	Deoxynucleoside kinase
C7M40_RS06265	COG0833	amino acid
C7M40_RS06270	COG0028	Belongs to the TPP enzyme family
C7M40_RS06275	COG1959	2 iron, 2 sulfur cluster binding
C7M40_RS06295	COG1316	TRANSCRIPTIONal
C7M40_RS06305	COG2966	Psort location CytoplasmicMembrane, score
C7M40_RS06310	COG1278	Cold shock
C7M40_RS06330	COG2814	Major facilitator Superfamily
C7M40_RS06375	COG0367	asparagine synthase
C7M40_RS06380	COG0527	aspartate kinase activity
C7M40_RS06385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7M40_RS06435	COG0640	Transcriptional regulator
C7M40_RS06440	COG0564	pseudouridine synthase activity
C7M40_RS06445	COG0514	ATP-dependent DNA helicase (RecQ)
C7M40_RS06465	COG4690	dipeptidase activity
C7M40_RS06470	COG2502	aspartate--ammonia ligase
C7M40_RS06475	COG0017	Asparaginyl-tRNA synthetase
C7M40_RS06480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C7M40_RS06490	COG1053	succinate dehydrogenase
C7M40_RS06495	COG0583	DNA-binding transcription factor activity
C7M40_RS06510	COG0572	uridine kinase
C7M40_RS06555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7M40_RS06560	COG0308	aminopeptidase N
C7M40_RS06590	COG1302	Protein conserved in bacteria
C7M40_RS06605	COG2261	transglycosylase associated protein
C7M40_RS06610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7M40_RS06610	COG2755	lipolytic protein G-D-S-L family
C7M40_RS06650	COG2814	Major facilitator Superfamily
C7M40_RS06655	COG1733	regulation of RNA biosynthetic process
C7M40_RS06660	COG1266	CAAX protease self-immunity
C7M40_RS06675	COG1396	sequence-specific DNA binding
C7M40_RS06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7M40_RS06685	COG0519	Catalyzes the synthesis of GMP from XMP
C7M40_RS06690	COG1072	(Pantothenic acid kinase))
C7M40_RS06695	COG2070	2-Nitropropane dioxygenase
C7M40_RS06705	COG3973	AAA domain
C7M40_RS06710	COG0586	Pfam SNARE associated Golgi protein
C7M40_RS06715	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS06720	COG2190	(PTS) system
C7M40_RS06720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS06720	COG1263	PTS System
C7M40_RS06725	COG3711	transcriptional antiterminator
C7M40_RS06730	COG0456	acetyltransferase
C7M40_RS06730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7M40_RS06735	COG0475	glutathione-regulated potassium exporter activity
C7M40_RS06735	COG0569	domain protein
C7M40_RS06740	COG0588	phosphoglycerate mutase activity
C7M40_RS06755	COG2076	Multidrug Resistance protein
C7M40_RS06765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7M40_RS06795	COG1846	Transcriptional regulator
C7M40_RS06800	COG0531	amino acid
C7M40_RS06805	COG3394	polysaccharide catabolic process
C7M40_RS06810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS06810	COG1263	PTS System
C7M40_RS06820	COG2190	(PTS) system
C7M40_RS06820	COG1263	PTS System
C7M40_RS06820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS06825	COG0765	amino acid transport
C7M40_RS06830	COG0765	amino acid transport
C7M40_RS06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M40_RS06850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M40_RS06855	COG0436	Aminotransferase
C7M40_RS06860	COG0546	phosphoglycolate phosphatase activity
C7M40_RS06875	COG0735	belongs to the Fur family
C7M40_RS06880	COG0194	GDP metabolic process
C7M40_RS06905	COG0531	amino acid
C7M40_RS06920	COG2936	dipeptidyl-peptidase activity
C7M40_RS06925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7M40_RS06925	COG2755	lipolytic protein G-D-S-L family
C7M40_RS06935	COG2267	carboxylic ester hydrolase activity
C7M40_RS06940	COG0028	Belongs to the TPP enzyme family
C7M40_RS06945	COG0196	riboflavin kinase activity
C7M40_RS06950	COG0028	Belongs to the TPP enzyme family
C7M40_RS06955	COG2252	PERMEase
C7M40_RS06970	COG3475	LICD family
C7M40_RS06980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7M40_RS06990	COG0477	Major facilitator Superfamily
C7M40_RS07005	COG1393	Belongs to the ArsC family
C7M40_RS07030	COG2017	converts alpha-aldose to the beta-anomer
C7M40_RS07040	COG0561	phosphatase activity
C7M40_RS07050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M40_RS07055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M40_RS07080	COG0025	NhaP-type Na H and K H
C7M40_RS07085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7M40_RS07095	COG0708	Exodeoxyribonuclease III
C7M40_RS07110	COG0802	atpase or kinase
C7M40_RS07115	COG0280	phosphate acetyltransferase
C7M40_RS07120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7M40_RS07125	COG0561	phosphatase activity
C7M40_RS07135	COG1126	abc transporter atp-binding protein
C7M40_RS07140	COG0765	amino acid transport
C7M40_RS07150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7M40_RS07155	COG0557	exoribonuclease II activity
C7M40_RS07165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7M40_RS07170	COG0038	chloride channel
C7M40_RS07185	COG0148	phosphopyruvate hydratase activity
C7M40_RS07190	COG0149	triose-phosphate isomerase activity
C7M40_RS07195	COG0126	phosphoglycerate kinase activity
C7M40_RS07205	COG2390	Transcriptional regulator
C7M40_RS07210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7M40_RS07220	COG0740	serine-type endopeptidase activity
C7M40_RS07225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M40_RS07235	COG1481	regulation of sporulation
C7M40_RS07240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7M40_RS07245	COG1660	Displays ATPase and GTPase activities
C7M40_RS07255	COG0165	Argininosuccinate lyase
C7M40_RS07260	COG0137	argininosuccinate synthase activity
C7M40_RS07265	COG1854	S-ribosylhomocysteine lyase activity
C7M40_RS07270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M40_RS07275	COG0556	nucleotide-excision repair
C7M40_RS07285	COG2814	Major facilitator Superfamily
C7M40_RS07295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS07305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M40_RS07315	COG2323	membrane
C7M40_RS07320	COG0492	ferredoxin-NADP+ reductase activity
C7M40_RS07325	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS07340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7M40_RS07345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7M40_RS07350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7M40_RS07355	COG1950	PFAM Membrane protein of
C7M40_RS07360	COG1983	PspC domain protein
C7M40_RS07365	COG0704	Plays a role in the regulation of phosphate uptake
C7M40_RS07370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7M40_RS07375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7M40_RS07380	COG0581	inorganic phosphate transmembrane transporter activity
C7M40_RS07385	COG0573	inorganic phosphate transmembrane transporter activity
C7M40_RS07390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7M40_RS07395	COG5002	protein histidine kinase activity
C7M40_RS07400	COG0745	RESPONSE REGULATOR receiver
C7M40_RS07415	COG0653	protein targeting
C7M40_RS07430	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7M40_RS07435	COG1739	Uncharacterized protein family UPF0029
C7M40_RS07440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7M40_RS07445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7M40_RS07450	COG0531	amino acid
C7M40_RS07455	COG0459	protein refolding
C7M40_RS07460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7M40_RS07470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7M40_RS07475	COG0488	(ABC) transporter
C7M40_RS07480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7M40_RS07485	COG0456	acetyltransferase
C7M40_RS07490	COG0456	acetyltransferase
C7M40_RS07495	COG1214	PFAM Peptidase M22, glycoprotease
C7M40_RS07505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C7M40_RS07515	COG3639	organic phosphonate transmembrane transporter activity
C7M40_RS07520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M40_RS07525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C7M40_RS07530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7M40_RS07545	COG4467	Involved in initiation control of chromosome replication
C7M40_RS07550	COG0470	DNA polymerase III
C7M40_RS07555	COG3870	Protein conserved in bacteria
C7M40_RS07560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7M40_RS07570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7M40_RS07575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7M40_RS07580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7M40_RS07595	COG2813	Specifically methylates the guanine in position
C7M40_RS07600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7M40_RS07605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7M40_RS07615	COG1611	Belongs to the LOG family
C7M40_RS07635	COG0222	ribosome binding
C7M40_RS07640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7M40_RS07645	COG0081	regulation of translation
C7M40_RS07650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7M40_RS07660	COG0250	Participates in transcription elongation, termination and antitermination
C7M40_RS07670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M40_RS07685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M40_RS07690	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7M40_RS07695	COG0215	cysteine-tRNA ligase activity
C7M40_RS07700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7M40_RS07705	COG4956	integral membrane protein (PIN domain superfamily)
C7M40_RS07715	COG0756	dUTP diphosphatase activity
C7M40_RS07725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7M40_RS07745	COG0588	phosphoglycerate mutase activity
C7M40_RS07750	COG0697	spore germination
C7M40_RS07760	COG1316	TRANSCRIPTIONal
C7M40_RS07765	COG0825	malonyl-CoA metabolic process
C7M40_RS07775	COG0439	Biotin carboxylase
C7M40_RS07785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M40_RS07790	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS07790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M40_RS07795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS07795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M40_RS07800	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7M40_RS07800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7M40_RS07810	COG3716	PTS system mannose fructose sorbose family IID component
C7M40_RS07815	COG3715	PTS system
C7M40_RS07850	COG0083	homoserine kinase activity
C7M40_RS07855	COG0460	homoserine dehydrogenase
C7M40_RS07860	COG3091	SprT-like family
C7M40_RS07865	COG2183	response to ionizing radiation
C7M40_RS07880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7M40_RS07885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7M40_RS07905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7M40_RS07955	COG3104	oligopeptide transport
C7M40_RS07995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7M40_RS08000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7M40_RS08005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7M40_RS08020	COG0037	tRNA processing
C7M40_RS08025	COG1098	S1 RNA binding domain
C7M40_RS08035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7M40_RS08040	COG2244	polysaccharide biosynthetic process
C7M40_RS08045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7M40_RS08050	COG0193	aminoacyl-tRNA hydrolase activity
C7M40_RS08055	COG0039	L-malate dehydrogenase activity
C7M40_RS08075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7M40_RS08080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M40_RS08085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7M40_RS08090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C7M40_RS08095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7M40_RS08100	COG0505	Belongs to the CarA family
C7M40_RS08105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7M40_RS08125	COG3158	transport of potassium into the cell
C7M40_RS08130	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7M40_RS08135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7M40_RS08140	COG0736	holo-[acyl-carrier-protein] synthase activity
C7M40_RS08155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7M40_RS08165	COG0501	Belongs to the peptidase M48B family
C7M40_RS08170	COG1704	LemA family
C7M40_RS08175	COG3764	Sortase (surface protein transpeptidase)
C7M40_RS08185	COG0254	rRNA binding
C7M40_RS08190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7M40_RS08195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M40_RS08210	COG1760	l-serine dehydratase
C7M40_RS08215	COG1760	l-serine dehydratase
C7M40_RS08220	COG0814	amino acid
C7M40_RS08225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7M40_RS08230	COG0504	CTP synthase activity
C7M40_RS08235	COG3343	RNA polymerase activity
C7M40_RS08245	COG0095	Lipoate-protein ligase
C7M40_RS08250	COG1078	dGTPase activity
C7M40_RS08270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7M40_RS08280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7M40_RS08285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M40_RS08305	COG1321	iron dependent repressor
C7M40_RS08305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M40_RS08310	COG1121	(ABC) transporter
C7M40_RS08315	COG1073	alpha beta
C7M40_RS08320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7M40_RS08325	COG4466	Protein conserved in bacteria
C7M40_RS08330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7M40_RS08335	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7M40_RS08340	COG0084	hydrolase, TatD family'
C7M40_RS08345	COG2814	Major facilitator Superfamily
C7M40_RS08350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M40_RS08350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M40_RS08360	COG1801	Protein of unknown function DUF72
C7M40_RS08365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7M40_RS08380	COG0248	Ppx GppA phosphatase
C7M40_RS08395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7M40_RS08405	COG1940	carbohydrate kinase activity
C7M40_RS08410	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS08415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS08430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS08435	COG2188	Transcriptional regulator
C7M40_RS08440	COG0180	Tryptophanyl-tRNA synthetase
C7M40_RS08445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M40_RS08450	COG3973	AAA domain
C7M40_RS08490	COG2274	protein secretion by the type I secretion system
C7M40_RS08515	COG3279	Response regulator of the LytR AlgR family
C7M40_RS08550	COG0463	Glycosyl transferase, family 2
C7M40_RS08595	COG1114	Component of the transport system for branched-chain amino acids
C7M40_RS08600	COG0561	phosphatase activity
C7M40_RS08610	COG0561	phosphatase activity
C7M40_RS08620	COG0110	maltose O-acetyltransferase activity
C7M40_RS08705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS08715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7M40_RS08725	COG1125	glycine betaine transport
C7M40_RS08745	COG0300	oxidoreductase activity
C7M40_RS08775	COG1881	PFAM PEBP family protein
C7M40_RS08780	COG3759	membrane
C7M40_RS08790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7M40_RS08810	COG0004	ammonium transporteR
C7M40_RS08830	COG1134	teichoic acid transport
C7M40_RS08835	COG1682	transport, permease protein
C7M40_RS08845	COG0436	Aminotransferase
C7M40_RS08860	COG1268	BioY protein
C7M40_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
C7M40_RS08895	COG1454	alcohol dehydrogenase
C7M40_RS08905	COG1131	(ABC) transporter
C7M40_RS08910	COG1725	Transcriptional regulator
C7M40_RS08940	COG3842	ATPase activity
C7M40_RS08980	COG1252	NADH dehydrogenase
C7M40_RS08985	COG1846	Transcriptional regulator
C7M40_RS08995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7M40_RS09025	COG1388	LysM domain
C7M40_RS09025	COG3942	CHAP domain
C7M40_RS09030	COG0741	lytic transglycosylase activity
C7M40_RS09045	COG1136	(ABC) transporter
C7M40_RS09050	COG0577	efflux transmembrane transporter activity
C7M40_RS09060	COG2818	Glycosylase
C7M40_RS09065	COG1033	growth of symbiont in host cell
C7M40_RS09065	COG2409	Drug exporters of the RND superfamily
C7M40_RS09075	COG2357	RelA SpoT domain protein
C7M40_RS09085	COG0277	FAD linked oxidase domain protein
C7M40_RS09090	COG1316	TRANSCRIPTIONal
C7M40_RS09105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS09110	COG1737	Transcriptional regulator
C7M40_RS09120	COG0745	RESPONSE REGULATOR receiver
C7M40_RS09125	COG5002	protein histidine kinase activity
C7M40_RS09155	COG1914	H( )-stimulated, divalent metal cation uptake system
C7M40_RS09160	COG1309	transcriptional regulator
C7M40_RS09165	COG1959	2 iron, 2 sulfur cluster binding
C7M40_RS09175	COG0163	prenyltransferase activity
C7M40_RS09185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS09185	COG1263	PTS System
C7M40_RS09185	COG2190	(PTS) system
C7M40_RS09190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS09190	COG2190	(PTS) system
C7M40_RS09190	COG1263	PTS System
C7M40_RS09195	COG0366	Alpha amylase catalytic
C7M40_RS09200	COG2188	Transcriptional regulator
C7M40_RS09220	COG0024	Methionine aminopeptidase
C7M40_RS09225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7M40_RS09230	COG0626	cystathionine gamma-synthase activity
C7M40_RS09235	COG1045	serine acetyltransferase
C7M40_RS09255	COG3964	amidohydrolase
C7M40_RS09270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS09275	COG2188	Transcriptional regulator
C7M40_RS09280	COG0431	NADPH-dependent FMN reductase
C7M40_RS09310	COG3118	belongs to the thioredoxin family
C7M40_RS09320	COG0246	Mannitol dehydrogenase
C7M40_RS09325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M40_RS09335	COG2213	PTS system mannitol-specific
C7M40_RS09345	COG0363	glucosamine-6-phosphate deaminase activity
C7M40_RS09360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7M40_RS09370	COG0386	Belongs to the glutathione peroxidase family
C7M40_RS09380	COG1122	ATPase activity
C7M40_RS09395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M40_RS09400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M40_RS09430	COG0667	Aldo Keto reductase
C7M40_RS09435	COG0406	alpha-ribazole phosphatase activity
C7M40_RS09440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7M40_RS09445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7M40_RS09455	COG4166	transmembrane transport
C7M40_RS09460	COG4166	transmembrane transport
C7M40_RS09540	COG3842	ATPase activity
C7M40_RS09555	COG3833	ABC-type maltose transport systems, permease component
C7M40_RS09560	COG1175	transmembrane transport
C7M40_RS09565	COG2182	Extracellular solute-binding protein
C7M40_RS09575	COG1609	Transcriptional regulator
C7M40_RS09580	COG1609	Transcriptional regulator
C7M40_RS09590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS09595	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C7M40_RS09600	COG1461	Dihydroxyacetone kinase
C7M40_RS09605	COG2376	Dihydroxyacetone kinase
C7M40_RS09610	COG2376	Dihydroxyacetone kinase
C7M40_RS09615	COG1309	transcriptional regulator
C7M40_RS09620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7M40_RS09625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C7M40_RS09640	COG1131	(ABC) transporter
C7M40_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS09670	COG2188	Transcriptional regulator
C7M40_RS09680	COG4720	Psort location CytoplasmicMembrane, score
C7M40_RS09685	COG1122	ATPase activity
C7M40_RS09690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C7M40_RS09720	COG0667	Aldo Keto reductase
C7M40_RS09725	COG0656	L-ascorbic acid biosynthetic process
C7M40_RS09730	COG2807	transmembrane transport
C7M40_RS09735	COG0640	Transcriptional regulator
C7M40_RS09770	COG1983	PspC domain protein
C7M40_RS09780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7M40_RS09795	COG1518	maintenance of DNA repeat elements
C7M40_RS09800	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C7M40_RS09805	COG2267	carboxylic ester hydrolase activity
C7M40_RS09815	COG1113	amino acid transport
C7M40_RS09830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M40_RS09840	COG0352	thiamine-phosphate diphosphorylase activity
C7M40_RS09845	COG0351	phosphomethylpyrimidine kinase
C7M40_RS09850	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C7M40_RS09860	COG1606	tRNA processing
C7M40_RS09865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS09870	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C7M40_RS09875	COG1691	(AIR) carboxylase
C7M40_RS09880	COG3875	lactate racemase activity
C7M40_RS09885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M40_RS09890	COG0310	cobalt ion transport
C7M40_RS09895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C7M40_RS09900	COG1122	ATPase activity
C7M40_RS09925	COG4166	transmembrane transport
C7M40_RS09935	COG3022	response to hydroperoxide
C7M40_RS09940	COG2267	carboxylic ester hydrolase activity
C7M40_RS09955	COG0604	alcohol dehydrogenase
C7M40_RS09980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C7M40_RS10000	COG2368	4-hydroxyphenylacetate
C7M40_RS10005	COG2365	Tyrosine phosphatase family
C7M40_RS10015	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C7M40_RS10020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M40_RS10025	COG2508	Transcriptional regulator
C7M40_RS10030	COG0778	Nitroreductase
C7M40_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS10045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7M40_RS10060	COG0471	metal ion transport
C7M40_RS10065	COG3976	FMN-binding domain protein
C7M40_RS10065	COG1053	succinate dehydrogenase
C7M40_RS10065	COG0431	NADPH-dependent FMN reductase
C7M40_RS10090	COG3586	endonuclease activity
C7M40_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
C7M40_RS10105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7M40_RS10110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M40_RS10115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C7M40_RS10120	COG4853	Protein conserved in bacteria
C7M40_RS10130	COG5002	protein histidine kinase activity
C7M40_RS10135	COG0745	RESPONSE REGULATOR receiver
C7M40_RS10150	COG1278	Cold shock
C7M40_RS10160	COG1554	hydrolase, family 65, central catalytic
C7M40_RS10165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M40_RS10175	COG3103	Sh3 type 3 domain protein
C7M40_RS10175	COG0366	Alpha amylase catalytic
C7M40_RS10180	COG0058	SHG alpha-glucan phosphorylase activity
C7M40_RS10185	COG0297	glycogen (starch) synthase activity
C7M40_RS10190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7M40_RS10195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7M40_RS10200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7M40_RS10205	COG4166	transmembrane transport
C7M40_RS10210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7M40_RS10215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7M40_RS10220	COG2814	Major facilitator Superfamily
C7M40_RS10225	COG0305	Participates in initiation and elongation during chromosome replication
C7M40_RS10230	COG0359	binds to the 23S rRNA
C7M40_RS10240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7M40_RS10245	COG0629	single-stranded DNA binding
C7M40_RS10250	COG0360	Binds together with S18 to 16S ribosomal RNA
C7M40_RS10260	COG0187	DNA topoisomerase II activity
C7M40_RS10265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7M40_RS10270	COG2501	S4 domain
C7M40_RS10275	COG0592	DNA-directed DNA polymerase activity
C7M40_RS10280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7M40_RS10285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7M40_RS10290	COG0594	ribonuclease P activity
C7M40_RS10295	COG0706	membrane insertase activity
C7M40_RS10300	COG4166	transmembrane transport
C7M40_RS10310	COG1847	R3H domain protein
C7M40_RS10315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7M40_RS10320	COG0445	tRNA wobble uridine modification
C7M40_RS10365	COG1307	EDD domain protein, DegV family
C7M40_RS10380	COG3479	Phenolic acid decarboxylase
C7M40_RS10385	COG1695	Transcriptional regulator
C7M40_RS10395	COG1012	belongs to the aldehyde dehydrogenase family
C7M40_RS10395	COG1454	alcohol dehydrogenase
C7M40_RS10400	COG1609	Transcriptional regulator
C7M40_RS10410	COG1869	D-ribose catabolic process
C7M40_RS10415	COG4975	Glucose uptake
C7M40_RS10435	COG3730	PTS system glucitol sorbitol-specific
C7M40_RS10440	COG3732	PTS system glucitol sorbitol-specific
C7M40_RS10455	COG2188	Transcriptional regulator
C7M40_RS10460	COG1132	(ABC) transporter
C7M40_RS10465	COG1132	(ABC) transporter
C7M40_RS10470	COG2207	Transcriptional regulator
C7M40_RS10470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7M40_RS10485	COG0395	ABC-type sugar transport system, permease component
C7M40_RS10495	COG0366	Alpha amylase catalytic
C7M40_RS10505	COG2972	Histidine kinase
C7M40_RS10510	COG4753	response regulator
C7M40_RS10510	COG2207	Transcriptional regulator
C7M40_RS10520	COG3842	ATPase activity
C7M40_RS10530	COG2188	Transcriptional regulator
C7M40_RS10540	COG0383	alpha-mannosidase activity
C7M40_RS10545	COG1940	carbohydrate kinase activity
C7M40_RS10550	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS10570	COG1609	Transcriptional regulator
C7M40_RS10580	COG1263	PTS System
C7M40_RS10580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS10600	COG1263	PTS System
C7M40_RS10600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS10605	COG1737	Transcriptional regulator
C7M40_RS10625	COG1263	PTS System
C7M40_RS10625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS10625	COG2190	(PTS) system
C7M40_RS10640	COG3775	system Galactitol-specific IIC component
C7M40_RS10655	COG1349	DNA-binding transcription factor activity
C7M40_RS10660	COG2207	Transcriptional regulator
C7M40_RS10665	COG2814	Major facilitator Superfamily
C7M40_RS10670	COG1070	Carbohydrate kinase
C7M40_RS10675	COG3254	rhamnose metabolic process
C7M40_RS10680	COG4806	L-rhamnose isomerase
C7M40_RS10685	COG0235	Class ii aldolase
C7M40_RS10700	COG0028	Belongs to the TPP enzyme family
C7M40_RS10705	COG1959	2 iron, 2 sulfur cluster binding
C7M40_RS10710	COG0028	Belongs to the TPP enzyme family
C7M40_RS10715	COG1304	FMN binding
C7M40_RS10730	COG4512	PFAM Accessory gene regulator B
C7M40_RS10750	COG1393	Belongs to the ArsC family
C7M40_RS10760	COG2261	transglycosylase associated protein
C7M40_RS10785	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7M40_RS10790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M40_RS10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7M40_RS10830	COG1737	Transcriptional regulator
C7M40_RS10835	COG1609	Transcriptional regulator
C7M40_RS10855	COG2160	L-arabinose isomerase activity
C7M40_RS10860	COG0110	maltose O-acetyltransferase activity
C7M40_RS10870	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7M40_RS10875	COG1349	DNA-binding transcription factor activity
C7M40_RS10885	COG3414	Phosphotransferase system galactitol-specific IIB component
C7M40_RS10890	COG3775	system Galactitol-specific IIC component
C7M40_RS10905	COG3711	transcriptional antiterminator
C7M40_RS10920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS10925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS10925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS10925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C7M40_RS10930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7M40_RS10935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7M40_RS10950	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C7M40_RS10965	COG2211	Major facilitator Superfamily
C7M40_RS10985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS10985	COG2190	(PTS) system
C7M40_RS10985	COG1263	PTS System
C7M40_RS10990	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS11010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7M40_RS11015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS11015	COG1263	PTS System
C7M40_RS11020	COG1737	Transcriptional regulator
C7M40_RS11025	COG2190	(PTS) system
C7M40_RS11025	COG1263	PTS System
C7M40_RS11025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS11030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS11030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M40_RS11030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS11035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS11035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7M40_RS11040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7M40_RS11060	COG3711	transcriptional antiterminator
C7M40_RS11070	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS11080	COG2971	BadF BadG BcrA BcrD
C7M40_RS11085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7M40_RS11090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS11110	COG2271	Major facilitator Superfamily
C7M40_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS11140	COG2271	Major facilitator Superfamily
C7M40_RS11145	COG0583	DNA-binding transcription factor activity
C7M40_RS11150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7M40_RS11155	COG0710	3-dehydroquinate dehydratase activity
C7M40_RS11175	COG0667	Aldo Keto reductase
C7M40_RS11180	COG1609	Transcriptional regulator
C7M40_RS11185	COG2017	converts alpha-aldose to the beta-anomer
C7M40_RS11190	COG2211	Major facilitator Superfamily
C7M40_RS11190	COG2190	(PTS) system
C7M40_RS11210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7M40_RS11215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7M40_RS11220	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7M40_RS11225	COG1609	Transcriptional regulator
C7M40_RS11230	COG2944	sequence-specific DNA binding
C7M40_RS11235	COG2184	nucleotidyltransferase activity
C7M40_RS11255	COG0477	Major facilitator Superfamily
C7M40_RS11265	COG1609	Transcriptional regulator
C7M40_RS11270	COG1874	Beta-galactosidase
C7M40_RS11280	COG1114	Component of the transport system for branched-chain amino acids
C7M40_RS11290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS11340	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS11350	COG3590	peptidase
C7M40_RS11355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M40_RS11375	COG1937	Protein conserved in bacteria
C7M40_RS11380	COG3118	belongs to the thioredoxin family
C7M40_RS11385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M40_RS11390	COG2217	Heavy metal translocating P-type atpase
C7M40_RS11405	COG2226	methyltransferase
C7M40_RS11455	COG0076	glutamate decarboxylase activity
C7M40_RS11480	COG2207	Transcriptional regulator
C7M40_RS11515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7M40_RS11520	COG1968	undecaprenyl-diphosphatase activity
C7M40_RS11540	COG0656	L-ascorbic acid biosynthetic process
C7M40_RS11550	COG0737	Belongs to the 5'-nucleotidase family
C7M40_RS11605	COG0477	Major facilitator Superfamily
C7M40_RS11630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C7M40_RS11645	COG0697	spore germination
C7M40_RS11665	COG0071	Belongs to the small heat shock protein (HSP20) family
C7M40_RS11680	COG1194	a g-specific adenine glycosylase
C7M40_RS11690	COG3189	MarR family transcriptional regulator
C7M40_RS11695	COG1393	Belongs to the ArsC family
C7M40_RS11710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7M40_RS11720	COG1113	amino acid transport
C7M40_RS11735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M40_RS11740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7M40_RS11760	COG2217	Heavy metal translocating P-type atpase
C7M40_RS11790	COG4989	oxidoreductase activity
C7M40_RS11795	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M40_RS11800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7M40_RS11805	COG1882	Formate acetyltransferase
C7M40_RS11810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7M40_RS11840	COG2814	Major facilitator Superfamily
C7M40_RS11845	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7M40_RS11860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C7M40_RS11865	COG0302	gtp cyclohydrolase
C7M40_RS11875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7M40_RS11885	COG0519	Catalyzes the synthesis of GMP from XMP
C7M40_RS11900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M40_RS11900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M40_RS11930	COG0640	Transcriptional regulator
C7M40_RS11935	COG1272	protein, Hemolysin III
C7M40_RS11950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M40_RS11955	COG0628	permease
C7M40_RS11960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C7M40_RS11965	COG3158	transport of potassium into the cell
C7M40_RS11970	COG0531	amino acid
C7M40_RS11980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7M40_RS11985	COG2365	Tyrosine phosphatase family
C7M40_RS11990	COG0516	GMP reductase activity
C7M40_RS11995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7M40_RS12000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7M40_RS12015	COG1929	Belongs to the glycerate kinase type-1 family
C7M40_RS12025	COG1562	ergosterol biosynthetic process
C7M40_RS12030	COG1233	COG1233 Phytoene dehydrogenase and related
C7M40_RS12035	COG2738	Putative neutral zinc metallopeptidase
C7M40_RS12045	COG1307	EDD domain protein, DegV family
C7M40_RS12080	COG0735	belongs to the Fur family
C7M40_RS12110	COG2190	(PTS) system
C7M40_RS12110	COG1263	PTS System
C7M40_RS12110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS12125	COG0561	phosphatase activity
C7M40_RS12135	COG0583	DNA-binding transcription factor activity
C7M40_RS12150	COG2190	(PTS) system
C7M40_RS12150	COG1263	PTS System
C7M40_RS12150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS12165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M40_RS12170	COG4619	ABC transporter
C7M40_RS12175	COG0390	transport system, permease component
C7M40_RS12185	COG1609	Transcriptional regulator
C7M40_RS12195	COG2190	(PTS) system
C7M40_RS12195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS12195	COG1263	PTS System
C7M40_RS12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M40_RS12225	COG1126	abc transporter atp-binding protein
C7M40_RS12230	COG0765	amino acid transport
C7M40_RS12235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M40_RS12240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M40_RS12245	COG0583	DNA-binding transcription factor activity
C7M40_RS12260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7M40_RS12265	COG0357	Ribosomal RNA small subunit methyltransferase G
C7M40_RS12275	COG1192	Involved in chromosome partitioning
C7M40_RS12280	COG1475	DNA binding
C7M40_RS12285	COG4481	Protein conserved in bacteria
C7M40_RS12290	COG0012	GTP binding
C7M40_RS12305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7M40_RS12325	COG1686	Belongs to the peptidase S11 family
C7M40_RS12330	COG1247	-acetyltransferase
C7M40_RS12370	COG0515	serine threonine protein kinase
C7M40_RS12370	COG2815	serine threonine protein kinase
C7M40_RS12380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7M40_RS12390	COG1846	Transcriptional regulator
C7M40_RS12390	COG1940	carbohydrate kinase activity
C7M40_RS12395	COG0628	permease
C7M40_RS12400	COG0588	phosphoglycerate mutase activity
C7M40_RS12425	COG0477	Major facilitator Superfamily
C7M40_RS12440	COG0656	L-ascorbic acid biosynthetic process
C7M40_RS12445	COG1376	ErfK ybiS ycfS ynhG family protein
C7M40_RS12470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C7M40_RS12480	COG1136	(ABC) transporter
C7M40_RS12480	COG0577	efflux transmembrane transporter activity
C7M40_RS12495	COG0693	protein deglycase activity
C7M40_RS12515	COG0789	Transcriptional regulator
C7M40_RS12535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS12540	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS12550	COG0783	Belongs to the Dps family
C7M40_RS12560	COG1053	succinate dehydrogenase
C7M40_RS12570	COG2816	NAD+ diphosphatase activity
C7M40_RS12580	COG0481	GTPase activity
C7M40_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS12620	COG0110	maltose O-acetyltransferase activity
C7M40_RS12625	COG4221	oxidoreductase activity
C7M40_RS12635	COG1309	transcriptional regulator
C7M40_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M40_RS12645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M40_RS12650	COG1120	ATPase activity
C7M40_RS12655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7M40_RS12665	COG0477	Major facilitator Superfamily
C7M40_RS12670	COG4989	oxidoreductase activity
C7M40_RS12690	COG0300	oxidoreductase activity
C7M40_RS12695	COG1733	regulation of RNA biosynthetic process
C7M40_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
C7M40_RS12720	COG1309	transcriptional regulator
C7M40_RS12735	COG3279	Response regulator of the LytR AlgR family
C7M40_RS12740	COG0367	asparagine synthase
C7M40_RS12750	COG2814	Major facilitator Superfamily
C7M40_RS12755	COG1733	regulation of RNA biosynthetic process
C7M40_RS12760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M40_RS12800	COG1063	alcohol dehydrogenase
C7M40_RS12855	COG2217	Heavy metal translocating P-type atpase
C7M40_RS12885	COG0531	amino acid
C7M40_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS12905	COG1473	amidohydrolase
C7M40_RS12915	COG1132	(ABC) transporter
C7M40_RS12920	COG1132	(ABC) transporter
C7M40_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS12965	COG4221	oxidoreductase activity
C7M40_RS12980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M40_RS13005	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7M40_RS13025	COG0741	lytic transglycosylase activity
C7M40_RS13030	COG0789	Transcriptional regulator
C7M40_RS13040	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS13045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS13050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS13085	COG1136	(ABC) transporter
C7M40_RS13085	COG0577	efflux transmembrane transporter activity
C7M40_RS13095	COG0640	Transcriptional regulator
C7M40_RS13115	COG1914	H( )-stimulated, divalent metal cation uptake system
C7M40_RS13125	COG2246	polysaccharide biosynthetic process
C7M40_RS13130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M40_RS13130	COG5549	protein import
C7M40_RS13145	COG0559	Belongs to the binding-protein-dependent transport system permease family
C7M40_RS13160	COG0410	ABC transporter
C7M40_RS13195	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7M40_RS13210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS13210	COG1263	PTS System
C7M40_RS13210	COG2190	(PTS) system
C7M40_RS13215	COG0778	Nitroreductase
C7M40_RS13225	COG1132	(ABC) transporter
C7M40_RS13230	COG1940	carbohydrate kinase activity
C7M40_RS13255	COG0697	spore germination
C7M40_RS13300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7M40_RS13310	COG0583	DNA-binding transcription factor activity
C7M40_RS13325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7M40_RS13335	COG0242	peptide deformylase activity
C7M40_RS13345	COG1328	CTP reductase activity
C7M40_RS13355	COG2200	EAL domain
C7M40_RS13395	COG2270	Major facilitator Superfamily
C7M40_RS13410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M40_RS13420	COG0561	phosphatase activity
C7M40_RS13425	COG0488	(ABC) transporter
C7M40_RS13455	COG0640	Transcriptional regulator
C7M40_RS13465	COG1511	domain protein
C7M40_RS13465	COG1511	domain protein
C7M40_RS13480	COG2814	Major facilitator Superfamily
C7M40_RS13485	COG1132	(ABC) transporter
C7M40_RS13490	COG1132	(ABC) transporter
C7M40_RS13495	COG0667	Aldo Keto reductase
C7M40_RS13505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7M40_RS13520	COG1011	Hydrolase
C7M40_RS13525	COG0110	maltose O-acetyltransferase activity
C7M40_RS13530	COG0589	response to stress
C7M40_RS13540	COG1028	Short-chain dehydrogenase reductase Sdr
C7M40_RS13545	COG1063	alcohol dehydrogenase
C7M40_RS13555	COG0583	DNA-binding transcription factor activity
C7M40_RS13580	COG0456	acetyltransferase
C7M40_RS13605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7M40_RS13625	COG0789	Transcriptional regulator
C7M40_RS13640	COG4221	oxidoreductase activity
C7M40_RS13650	COG4152	abc transporter atp-binding protein
C7M40_RS13655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7M40_RS13670	COG0438	transferase activity, transferring glycosyl groups
C7M40_RS13680	COG0583	DNA-binding transcription factor activity
C7M40_RS13685	COG2855	membrane
C7M40_RS13690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M40_RS13700	COG2814	Major facilitator Superfamily
C7M40_RS13710	COG2814	Major facilitator Superfamily
C7M40_RS13750	COG1136	(ABC) transporter
C7M40_RS13755	COG0577	efflux transmembrane transporter activity
C7M40_RS13775	COG4978	Transcriptional regulator
C7M40_RS13775	COG0789	Transcriptional regulator
C7M40_RS13780	COG1811	Na channel or pump
C7M40_RS13795	COG4990	cell redox homeostasis
C7M40_RS13810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7M40_RS13815	COG4720	Psort location CytoplasmicMembrane, score
C7M40_RS13875	COG0531	amino acid
C7M40_RS13880	COG0710	3-dehydroquinate dehydratase activity
C7M40_RS13900	COG0716	FMN binding
C7M40_RS13925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M40_RS13930	COG0561	phosphatase activity
C7M40_RS13945	COG1216	Glycosyl transferase, family 2
C7M40_RS13950	COG2188	Transcriptional regulator
C7M40_RS13955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M40_RS13960	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7M40_RS13965	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS13970	COG2723	6-phospho-beta-galactosidase activity
C7M40_RS13975	COG3048	D-serine ammonia-lyase activity
C7M40_RS13980	COG1131	(ABC) transporter
C7M40_RS13990	COG1309	transcriptional regulator
C7M40_RS13995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7M40_RS14000	COG1827	regulation of RNA biosynthetic process
C7M40_RS14035	COG1051	belongs to the nudix hydrolase family
C7M40_RS14040	COG0110	maltose O-acetyltransferase activity
C7M40_RS14050	COG0561	phosphatase activity
C7M40_RS14080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7M40_RS14100	COG2246	polysaccharide biosynthetic process
C7M40_RS14110	COG0589	response to stress
C7M40_RS14125	COG1131	(ABC) transporter
C7M40_RS14130	COG1725	Transcriptional regulator
C7M40_RS14145	COG1136	(ABC) transporter
C7M40_RS14165	COG2365	Tyrosine phosphatase family
C7M40_RS14170	COG0095	Lipoate-protein ligase
C7M40_RS14175	COG3976	FMN-binding domain protein
C7M40_RS14175	COG0431	NADPH-dependent FMN reductase
C7M40_RS14175	COG1053	succinate dehydrogenase
C7M40_RS14180	COG1053	succinate dehydrogenase
C7M40_RS14180	COG0431	NADPH-dependent FMN reductase
C7M40_RS14180	COG3976	FMN-binding domain protein
C7M40_RS14190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7M40_RS14195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7M40_RS14200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M40_RS14205	COG0047	phosphoribosylformylglycinamidine synthase activity
C7M40_RS14210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M40_RS14220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7M40_RS14225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7M40_RS14230	COG0138	bifunctional purine biosynthesis protein purh
C7M40_RS14235	COG0151	Belongs to the GarS family
C7M40_RS14245	COG1215	transferase activity, transferring glycosyl groups
C7M40_RS14265	COG2252	PERMEase
C7M40_RS14270	COG2233	PERMEase
C7M40_RS14275	COG2508	Transcriptional regulator
C7M40_RS14280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7M40_RS14285	COG0540	Belongs to the ATCase OTCase family
C7M40_RS14290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7M40_RS14295	COG0505	Belongs to the CarA family
C7M40_RS14300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7M40_RS14305	COG0167	dihydroorotate dehydrogenase activity
C7M40_RS14310	COG0284	orotidine-5'-phosphate decarboxylase activity
C7M40_RS14315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7M40_RS14325	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7M40_RS14330	COG1074	ATP-dependent DNA helicase activity
C7M40_RS14340	COG0702	epimerase
C7M40_RS14345	COG0583	DNA-binding transcription factor activity
C7M40_RS14360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M40_RS14365	COG0436	Aminotransferase
C7M40_RS14370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M40_RS14375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7M40_RS14385	COG0604	alcohol dehydrogenase
C7M40_RS14390	COG0789	Transcriptional regulator
C7M40_RS14395	COG2814	Major facilitator Superfamily
C7M40_RS14400	COG0025	NhaP-type Na H and K H
C7M40_RS14405	COG1780	Probably involved in ribonucleotide reductase function
C7M40_RS14410	COG1253	flavin adenine dinucleotide binding
C7M40_RS14440	COG1418	mRNA catabolic process
C7M40_RS14450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7M40_RS14455	COG2188	Transcriptional regulator
C7M40_RS14465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7M40_RS14480	COG1396	sequence-specific DNA binding
C7M40_RS14485	COG0564	pseudouridine synthase activity
C7M40_RS14490	COG0589	response to stress
C7M40_RS14495	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7M40_RS14500	COG0095	Lipoate-protein ligase
C7M40_RS14530	COG0626	cystathionine gamma-synthase activity
C7M40_RS14535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7M40_RS14540	COG1073	alpha beta
C7M40_RS14550	COG0028	Belongs to the TPP enzyme family
C7M40_RS14590	COG1725	Transcriptional regulator
C7M40_RS14595	COG1131	(ABC) transporter
C7M40_RS14605	COG1335	isochorismatase
C7M40_RS14610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7M40_RS14615	COG0025	NhaP-type Na H and K H
C7M40_RS14620	COG0673	inositol 2-dehydrogenase activity
C7M40_RS14625	COG0673	inositol 2-dehydrogenase activity
C7M40_RS14635	COG1609	Transcriptional regulator
C7M40_RS14645	COG0328	RNA-DNA hybrid ribonuclease activity
C7M40_RS14655	COG0778	Nitroreductase
C7M40_RS14660	COG2326	polyphosphate kinase activity
C7M40_RS14675	COG0492	ferredoxin-NADP+ reductase activity
C7M40_RS14680	COG2826	transposase and inactivated derivatives, IS30 family
C7M40_RS14685	COG0584	glycerophosphoryl diester phosphodiesterase
C7M40_RS14690	COG1368	sulfuric ester hydrolase activity
C7M40_RS14710	COG3548	integral membrane protein
C7M40_RS14725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7M40_RS14750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7M40_RS14755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C7M40_RS14760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7M40_RS14765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7M40_RS14770	COG0131	Imidazoleglycerol-phosphate dehydratase
C7M40_RS14775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7M40_RS14780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7M40_RS14785	COG0107	imidazoleglycerol-phosphate synthase activity
C7M40_RS14790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7M40_RS14795	COG0140	phosphoribosyl-ATP diphosphatase activity
C7M40_RS14800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7M40_RS14805	COG0110	maltose O-acetyltransferase activity
C7M40_RS14810	COG0861	Integral membrane protein TerC family
C7M40_RS14815	COG2084	Dehydrogenase
C7M40_RS14820	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M40_RS14830	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7M40_RS14840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C7M40_RS14855	COG1307	EDD domain protein, DegV family
C7M40_RS14860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M40_RS14865	COG2190	(PTS) system
C7M40_RS14865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS14865	COG1263	PTS System
C7M40_RS14885	COG0488	(ABC) transporter
C7M40_RS14890	COG3706	GGDEF domain
C7M40_RS14905	COG1522	sequence-specific DNA binding
C7M40_RS14910	COG0791	NLP P60 protein
C7M40_RS14930	COG0477	Major facilitator Superfamily
C7M40_RS14955	COG3830	Belongs to the UPF0237 family
C7M40_RS14960	COG2848	UPF0210 protein
C7M40_RS14965	COG0745	RESPONSE REGULATOR receiver
C7M40_RS14970	COG5002	protein histidine kinase activity
C7M40_RS14970	COG3850	Histidine kinase
C7M40_RS14975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7M40_RS14980	COG4975	Glucose uptake
C7M40_RS14985	COG0166	Belongs to the GPI family
C7M40_RS14995	COG0577	efflux transmembrane transporter activity
C7M40_RS14995	COG1136	(ABC) transporter
C7M40_RS15005	COG1132	(ABC) transporter
C7M40_RS15050	COG4932	domain protein
C7M40_RS15050	COG4886	Leucine-rich repeat (LRR) protein
C7M40_RS15130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C7M40_RS15140	COG1970	mechanosensitive ion channel activity
C7M40_RS15180	COG1396	sequence-specific DNA binding
C7M40_RS15250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7M40_RS15355	COG3620	sequence-specific DNA binding
C7M40_RS15370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M40_RS15390	COG1486	melibiose metabolic process
C7M40_RS15525	COG2274	protein secretion by the type I secretion system
C7M40_RS15555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C7M40_RS15580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7M40_RS15585	COG1984	allophanate hydrolase subunit 2
C7M40_RS15590	COG0511	ligase activity, forming carbon-carbon bonds
C7M40_RS15595	COG0439	Biotin carboxylase
C7M40_RS15600	COG4336	lyase activity
C7M40_RS15605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C7M40_RS15610	COG1914	H( )-stimulated, divalent metal cation uptake system
C7M40_RS15630	COG1192	Involved in chromosome partitioning
C7M40_RS15635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7M40_RS15680	COG0602	queuosine metabolic process
C7M40_RS15685	COG1328	CTP reductase activity
C7M40_RS15690	COG3316	Transposase and inactivated derivatives
C7M40_RS15695	COG0662	Cupin 2, conserved barrel domain protein
C7M40_RS15710	COG2814	Major facilitator Superfamily
C7M40_RS15725	COG0584	glycerophosphoryl diester phosphodiesterase
C7M40_RS15735	COG0395	ABC-type sugar transport system, permease component
C7M40_RS15740	COG1175	transmembrane transport
C7M40_RS15755	COG2826	transposase and inactivated derivatives, IS30 family
C7M40_RS15760	COG2190	(PTS) system
C7M40_RS15760	COG1263	PTS System
C7M40_RS15760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M40_RS15765	COG4948	Mandelate Racemase Muconate Lactonizing
C7M40_RS15770	COG2271	Major facilitator Superfamily
C7M40_RS15790	COG2801	Transposase and inactivated derivatives
C7M40_RS15830	COG1192	Involved in chromosome partitioning
C7M40_RS15885	COG1621	beta-fructofuranosidase activity
C7M40_RS15890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7M40_RS15895	COG3118	belongs to the thioredoxin family
C7M40_RS15900	COG0492	ferredoxin-NADP+ reductase activity
C7M40_RS15910	COG3118	belongs to the thioredoxin family
C7M40_RS15930	COG1846	Transcriptional regulator
C7M40_RS15980	COG2826	transposase and inactivated derivatives, IS30 family
C7M40_RS15995	COG1940	carbohydrate kinase activity
C7M40_RS16000	COG1609	Transcriptional regulator
C7M40_RS16005	COG2223	nitrite transmembrane transporter activity
C7M40_RS16010	COG1621	beta-fructofuranosidase activity
C7M40_RS16015	COG4372	Transposase
C7M40_RS16040	COG0582	viral genome integration into host DNA
C7M40_RS16085	COG2801	Transposase and inactivated derivatives
C7M40_RS16120	COG3716	PTS system mannose fructose sorbose family IID component
C7M40_RS16150	COG0367	asparagine synthase
C7M40_RS16160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M40_RS16170	COG4166	transmembrane transport
C7M40_RS16175	COG1363	Peptidase, m42
C7M40_RS16180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M40_RS16195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M40_RS16215	COG1192	Involved in chromosome partitioning
C7M40_RS16400	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7M40_RS16405	COG1376	ErfK ybiS ycfS ynhG family protein