locus-tag	class	description
S102022_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S102022_RS00010	COG0592	DNA-directed DNA polymerase activity
S102022_RS00015	COG2501	S4 domain
S102022_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S102022_RS00025	COG0187	DNA topoisomerase II activity
S102022_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
S102022_RS00040	COG0629	single-stranded DNA binding
S102022_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S102022_RS00055	COG0359	binds to the 23S rRNA
S102022_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
S102022_RS00065	COG2814	Major facilitator Superfamily
S102022_RS00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S102022_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S102022_RS00085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S102022_RS00090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S102022_RS00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S102022_RS00100	COG0297	glycogen (starch) synthase activity
S102022_RS00105	COG0058	SHG alpha-glucan phosphorylase activity
S102022_RS00110	COG0366	Alpha amylase catalytic
S102022_RS00110	COG3103	Sh3 type 3 domain protein
S102022_RS00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S102022_RS00125	COG1554	hydrolase, family 65, central catalytic
S102022_RS00135	COG1278	Cold shock
S102022_RS00150	COG0745	RESPONSE REGULATOR receiver
S102022_RS00155	COG5002	protein histidine kinase activity
S102022_RS00165	COG4853	Protein conserved in bacteria
S102022_RS00170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S102022_RS00175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S102022_RS00180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S102022_RS00250	COG1012	belongs to the aldehyde dehydrogenase family
S102022_RS00255	COG3586	endonuclease activity
S102022_RS00260	COG1573	uracil-dna glycosylase
S102022_RS00280	COG0431	NADPH-dependent FMN reductase
S102022_RS00280	COG1053	succinate dehydrogenase
S102022_RS00280	COG3976	FMN-binding domain protein
S102022_RS00285	COG0471	metal ion transport
S102022_RS00300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S102022_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS00315	COG0778	Nitroreductase
S102022_RS00325	COG2508	Transcriptional regulator
S102022_RS00335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S102022_RS00350	COG2365	Tyrosine phosphatase family
S102022_RS00355	COG2368	4-hydroxyphenylacetate
S102022_RS00375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S102022_RS00405	COG0604	alcohol dehydrogenase
S102022_RS00435	COG2267	carboxylic ester hydrolase activity
S102022_RS00440	COG3022	response to hydroperoxide
S102022_RS00450	COG4166	transmembrane transport
S102022_RS00475	COG1122	ATPase activity
S102022_RS00480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S102022_RS00485	COG0310	cobalt ion transport
S102022_RS00490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S102022_RS00495	COG3875	lactate racemase activity
S102022_RS00500	COG1691	(AIR) carboxylase
S102022_RS00505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
S102022_RS00510	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
S102022_RS00515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS00520	COG1606	tRNA processing
S102022_RS00530	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S102022_RS00535	COG0351	phosphomethylpyrimidine kinase
S102022_RS00540	COG0352	thiamine-phosphate diphosphorylase activity
S102022_RS00550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S102022_RS00565	COG1113	amino acid transport
S102022_RS00575	COG2267	carboxylic ester hydrolase activity
S102022_RS00580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S102022_RS00590	COG1983	PspC domain protein
S102022_RS00630	COG2807	transmembrane transport
S102022_RS00635	COG0656	L-ascorbic acid biosynthetic process
S102022_RS00640	COG0667	Aldo Keto reductase
S102022_RS00670	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S102022_RS00675	COG1122	ATPase activity
S102022_RS00680	COG4720	Psort location CytoplasmicMembrane, score
S102022_RS00690	COG2188	Transcriptional regulator
S102022_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS00720	COG1131	(ABC) transporter
S102022_RS00735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S102022_RS00740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S102022_RS00745	COG1309	transcriptional regulator
S102022_RS00750	COG2376	Dihydroxyacetone kinase
S102022_RS00755	COG2376	Dihydroxyacetone kinase
S102022_RS00760	COG1461	Dihydroxyacetone kinase
S102022_RS00765	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
S102022_RS00770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS00775	COG1609	Transcriptional regulator
S102022_RS00780	COG1609	Transcriptional regulator
S102022_RS00785	COG0366	Alpha amylase catalytic
S102022_RS00790	COG2182	Extracellular solute-binding protein
S102022_RS00795	COG1175	transmembrane transport
S102022_RS00800	COG3833	ABC-type maltose transport systems, permease component
S102022_RS00815	COG3842	ATPase activity
S102022_RS00870	COG1757	Na H antiporter
S102022_RS00895	COG4166	transmembrane transport
S102022_RS00900	COG4166	transmembrane transport
S102022_RS00910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S102022_RS00915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S102022_RS00920	COG0406	alpha-ribazole phosphatase activity
S102022_RS00925	COG0667	Aldo Keto reductase
S102022_RS00955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S102022_RS00960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S102022_RS00965	COG0488	(ABC) transporter
S102022_RS00975	COG4172	Belongs to the ABC transporter superfamily
S102022_RS00985	COG0386	Belongs to the glutathione peroxidase family
S102022_RS00995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S102022_RS01010	COG0363	glucosamine-6-phosphate deaminase activity
S102022_RS01020	COG3976	FMN-binding domain protein
S102022_RS01020	COG1053	succinate dehydrogenase
S102022_RS01035	COG2213	PTS system mannitol-specific
S102022_RS01045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS01050	COG0246	Mannitol dehydrogenase
S102022_RS01060	COG3118	belongs to the thioredoxin family
S102022_RS01090	COG0431	NADPH-dependent FMN reductase
S102022_RS01095	COG1045	serine acetyltransferase
S102022_RS01100	COG0626	cystathionine gamma-synthase activity
S102022_RS01105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S102022_RS01135	COG2188	Transcriptional regulator
S102022_RS01140	COG0366	Alpha amylase catalytic
S102022_RS01145	COG1263	PTS System
S102022_RS01145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS01145	COG2190	(PTS) system
S102022_RS01150	COG1263	PTS System
S102022_RS01150	COG2190	(PTS) system
S102022_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS01160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S102022_RS01165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S102022_RS01170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S102022_RS01175	COG0163	prenyltransferase activity
S102022_RS01185	COG1959	2 iron, 2 sulfur cluster binding
S102022_RS01190	COG1309	transcriptional regulator
S102022_RS01195	COG1914	H( )-stimulated, divalent metal cation uptake system
S102022_RS01215	COG2814	Major facilitator Superfamily
S102022_RS01225	COG5002	protein histidine kinase activity
S102022_RS01230	COG0745	RESPONSE REGULATOR receiver
S102022_RS01240	COG1737	Transcriptional regulator
S102022_RS01245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS01260	COG1316	TRANSCRIPTIONal
S102022_RS01265	COG0277	FAD linked oxidase domain protein
S102022_RS01275	COG2357	RelA SpoT domain protein
S102022_RS01285	COG1033	growth of symbiont in host cell
S102022_RS01285	COG2409	Drug exporters of the RND superfamily
S102022_RS01290	COG2818	Glycosylase
S102022_RS01300	COG0577	efflux transmembrane transporter activity
S102022_RS01305	COG1136	(ABC) transporter
S102022_RS01320	COG0741	lytic transglycosylase activity
S102022_RS01325	COG1388	LysM domain
S102022_RS01325	COG3942	CHAP domain
S102022_RS01355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S102022_RS01365	COG1846	Transcriptional regulator
S102022_RS01370	COG1252	NADH dehydrogenase
S102022_RS01395	COG3842	ATPase activity
S102022_RS01425	COG1725	Transcriptional regulator
S102022_RS01430	COG1131	(ABC) transporter
S102022_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
S102022_RS01440	COG1454	alcohol dehydrogenase
S102022_RS01475	COG1268	BioY protein
S102022_RS01490	COG0436	Aminotransferase
S102022_RS01500	COG1682	transport, permease protein
S102022_RS01505	COG1134	teichoic acid transport
S102022_RS01520	COG2814	Major facilitator Superfamily
S102022_RS01525	COG0004	ammonium transporteR
S102022_RS01545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S102022_RS01555	COG3759	membrane
S102022_RS01560	COG1881	PFAM PEBP family protein
S102022_RS01590	COG0300	oxidoreductase activity
S102022_RS01610	COG1125	glycine betaine transport
S102022_RS01620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S102022_RS01630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS01715	COG0110	maltose O-acetyltransferase activity
S102022_RS01725	COG0561	phosphatase activity
S102022_RS01735	COG0561	phosphatase activity
S102022_RS01740	COG1114	Component of the transport system for branched-chain amino acids
S102022_RS01765	COG3290	protein histidine kinase activity
S102022_RS01790	COG2274	protein secretion by the type I secretion system
S102022_RS01825	COG3973	AAA domain
S102022_RS01830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S102022_RS01835	COG0180	Tryptophanyl-tRNA synthetase
S102022_RS01840	COG2188	Transcriptional regulator
S102022_RS01845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS01860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS01865	COG2723	6-phospho-beta-galactosidase activity
S102022_RS01870	COG1940	carbohydrate kinase activity
S102022_RS01880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S102022_RS01895	COG0248	Ppx GppA phosphatase
S102022_RS01910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S102022_RS01915	COG1801	Protein of unknown function DUF72
S102022_RS01925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S102022_RS01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S102022_RS01935	COG2814	Major facilitator Superfamily
S102022_RS01950	COG0084	hydrolase, TatD family'
S102022_RS01955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S102022_RS01960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S102022_RS01965	COG4466	Protein conserved in bacteria
S102022_RS01970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S102022_RS01975	COG1073	alpha beta
S102022_RS01980	COG1121	(ABC) transporter
S102022_RS01985	COG1321	iron dependent repressor
S102022_RS01985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S102022_RS02010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S102022_RS02015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S102022_RS02025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S102022_RS02045	COG1078	dGTPase activity
S102022_RS02050	COG0095	Lipoate-protein ligase
S102022_RS02060	COG3343	RNA polymerase activity
S102022_RS02065	COG0504	CTP synthase activity
S102022_RS02075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S102022_RS02080	COG0814	amino acid
S102022_RS02090	COG1760	l-serine dehydratase
S102022_RS02095	COG1760	l-serine dehydratase
S102022_RS02110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S102022_RS02115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S102022_RS02120	COG0254	rRNA binding
S102022_RS02130	COG3764	Sortase (surface protein transpeptidase)
S102022_RS02135	COG1704	LemA family
S102022_RS02140	COG0501	Belongs to the peptidase M48B family
S102022_RS02150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S102022_RS02165	COG0736	holo-[acyl-carrier-protein] synthase activity
S102022_RS02170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S102022_RS02175	COG2337	Toxic component of a toxin-antitoxin (TA) module
S102022_RS02180	COG3158	transport of potassium into the cell
S102022_RS02185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S102022_RS02190	COG0505	Belongs to the CarA family
S102022_RS02195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S102022_RS02200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S102022_RS02205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S102022_RS02210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S102022_RS02215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S102022_RS02235	COG0039	L-malate dehydrogenase activity
S102022_RS02240	COG0193	aminoacyl-tRNA hydrolase activity
S102022_RS02245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S102022_RS02250	COG2244	polysaccharide biosynthetic process
S102022_RS02255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S102022_RS02265	COG1098	S1 RNA binding domain
S102022_RS02270	COG0037	tRNA processing
S102022_RS02285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S102022_RS02290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S102022_RS02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S102022_RS02335	COG3104	oligopeptide transport
S102022_RS02385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S102022_RS02395	COG2188	Transcriptional regulator
S102022_RS02405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S102022_RS02410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S102022_RS02425	COG2183	response to ionizing radiation
S102022_RS02430	COG3091	SprT-like family
S102022_RS02435	COG0460	homoserine dehydrogenase
S102022_RS02440	COG0083	homoserine kinase activity
S102022_RS02460	COG3715	PTS system
S102022_RS02465	COG3716	PTS system mannose fructose sorbose family IID component
S102022_RS02475	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S102022_RS02475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S102022_RS02480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS02480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS02485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS02485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS02490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S102022_RS02500	COG0439	Biotin carboxylase
S102022_RS02510	COG0825	malonyl-CoA metabolic process
S102022_RS02515	COG1316	TRANSCRIPTIONal
S102022_RS02525	COG0697	spore germination
S102022_RS02530	COG0588	phosphoglycerate mutase activity
S102022_RS02545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S102022_RS02555	COG0756	dUTP diphosphatase activity
S102022_RS02580	COG4956	integral membrane protein (PIN domain superfamily)
S102022_RS02585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S102022_RS02590	COG0215	cysteine-tRNA ligase activity
S102022_RS02595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S102022_RS02600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S102022_RS02615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S102022_RS02625	COG0250	Participates in transcription elongation, termination and antitermination
S102022_RS02635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S102022_RS02640	COG0081	regulation of translation
S102022_RS02645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S102022_RS02650	COG0222	ribosome binding
S102022_RS02670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S102022_RS02680	COG1970	mechanosensitive ion channel activity
S102022_RS02715	COG1396	sequence-specific DNA binding
S102022_RS02840	COG1783	phage Terminase large subunit
S102022_RS02985	COG1611	Belongs to the LOG family
S102022_RS02995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S102022_RS03000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S102022_RS03005	COG2813	Specifically methylates the guanine in position
S102022_RS03020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S102022_RS03025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S102022_RS03030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S102022_RS03040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S102022_RS03045	COG3870	Protein conserved in bacteria
S102022_RS03050	COG0470	DNA polymerase III
S102022_RS03055	COG4467	Involved in initiation control of chromosome replication
S102022_RS03070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S102022_RS03075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S102022_RS03080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S102022_RS03085	COG3639	organic phosphonate transmembrane transporter activity
S102022_RS03095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S102022_RS03105	COG1214	PFAM Peptidase M22, glycoprotease
S102022_RS03110	COG0456	acetyltransferase
S102022_RS03115	COG0456	acetyltransferase
S102022_RS03120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S102022_RS03130	COG0488	(ABC) transporter
S102022_RS03135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S102022_RS03145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S102022_RS03150	COG0459	protein refolding
S102022_RS03155	COG0531	amino acid
S102022_RS03160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S102022_RS03165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S102022_RS03170	COG1739	Uncharacterized protein family UPF0029
S102022_RS03175	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S102022_RS03180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S102022_RS03190	COG0653	protein targeting
S102022_RS03195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S102022_RS03205	COG0745	RESPONSE REGULATOR receiver
S102022_RS03210	COG5002	protein histidine kinase activity
S102022_RS03215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S102022_RS03220	COG0573	inorganic phosphate transmembrane transporter activity
S102022_RS03225	COG0581	inorganic phosphate transmembrane transporter activity
S102022_RS03230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S102022_RS03235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S102022_RS03240	COG0704	Plays a role in the regulation of phosphate uptake
S102022_RS03245	COG1983	PspC domain protein
S102022_RS03250	COG1950	PFAM Membrane protein of
S102022_RS03255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S102022_RS03260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S102022_RS03265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S102022_RS03270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S102022_RS03285	COG0492	ferredoxin-NADP+ reductase activity
S102022_RS03290	COG2323	membrane
S102022_RS03300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S102022_RS03310	COG0446	pyridine nucleotide-disulphide oxidoreductase
S102022_RS03320	COG2814	Major facilitator Superfamily
S102022_RS03330	COG0556	nucleotide-excision repair
S102022_RS03335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S102022_RS03340	COG1854	S-ribosylhomocysteine lyase activity
S102022_RS03345	COG0137	argininosuccinate synthase activity
S102022_RS03350	COG0165	Argininosuccinate lyase
S102022_RS03360	COG1660	Displays ATPase and GTPase activities
S102022_RS03370	COG1481	regulation of sporulation
S102022_RS03380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S102022_RS03385	COG0740	serine-type endopeptidase activity
S102022_RS03395	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S102022_RS03400	COG2390	Transcriptional regulator
S102022_RS03410	COG0126	phosphoglycerate kinase activity
S102022_RS03415	COG0149	triose-phosphate isomerase activity
S102022_RS03420	COG0148	phosphopyruvate hydratase activity
S102022_RS03435	COG0038	chloride channel
S102022_RS03440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S102022_RS03450	COG0557	exoribonuclease II activity
S102022_RS03455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S102022_RS03465	COG0765	amino acid transport
S102022_RS03470	COG1126	abc transporter atp-binding protein
S102022_RS03480	COG0561	phosphatase activity
S102022_RS03485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S102022_RS03490	COG0280	phosphate acetyltransferase
S102022_RS03495	COG0802	atpase or kinase
S102022_RS03510	COG0708	Exodeoxyribonuclease III
S102022_RS03520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S102022_RS03525	COG0025	NhaP-type Na H and K H
S102022_RS03550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S102022_RS03555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S102022_RS03565	COG0561	phosphatase activity
S102022_RS03575	COG2017	converts alpha-aldose to the beta-anomer
S102022_RS03590	COG0778	Nitroreductase
S102022_RS03610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S102022_RS03625	COG1393	Belongs to the ArsC family
S102022_RS03640	COG0477	Major facilitator Superfamily
S102022_RS03645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S102022_RS03645	COG0248	Ppx GppA phosphatase
S102022_RS03650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S102022_RS03660	COG3475	LICD family
S102022_RS03675	COG2252	PERMEase
S102022_RS03680	COG0028	Belongs to the TPP enzyme family
S102022_RS03685	COG0196	riboflavin kinase activity
S102022_RS03690	COG0028	Belongs to the TPP enzyme family
S102022_RS03695	COG2267	carboxylic ester hydrolase activity
S102022_RS03705	COG2755	lipolytic protein G-D-S-L family
S102022_RS03705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S102022_RS03710	COG2936	dipeptidyl-peptidase activity
S102022_RS03725	COG0531	amino acid
S102022_RS03750	COG0194	GDP metabolic process
S102022_RS03755	COG0735	belongs to the Fur family
S102022_RS03770	COG0546	phosphoglycolate phosphatase activity
S102022_RS03775	COG0436	Aminotransferase
S102022_RS03780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S102022_RS03800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S102022_RS03805	COG0765	amino acid transport
S102022_RS03810	COG0765	amino acid transport
S102022_RS03815	COG2190	(PTS) system
S102022_RS03815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS03815	COG1263	PTS System
S102022_RS03825	COG1263	PTS System
S102022_RS03825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS03830	COG3394	polysaccharide catabolic process
S102022_RS03835	COG0531	amino acid
S102022_RS03845	COG1846	Transcriptional regulator
S102022_RS03875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S102022_RS03885	COG2076	Multidrug Resistance protein
S102022_RS03900	COG0588	phosphoglycerate mutase activity
S102022_RS03905	COG0569	domain protein
S102022_RS03905	COG0475	glutathione-regulated potassium exporter activity
S102022_RS03910	COG0456	acetyltransferase
S102022_RS03910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S102022_RS03915	COG0586	Pfam SNARE associated Golgi protein
S102022_RS03920	COG3973	AAA domain
S102022_RS03925	COG2070	2-Nitropropane dioxygenase
S102022_RS03930	COG1072	(Pantothenic acid kinase))
S102022_RS03935	COG0519	Catalyzes the synthesis of GMP from XMP
S102022_RS03935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S102022_RS03945	COG1396	sequence-specific DNA binding
S102022_RS03955	COG1266	CAAX protease self-immunity
S102022_RS03960	COG1733	regulation of RNA biosynthetic process
S102022_RS03965	COG2814	Major facilitator Superfamily
S102022_RS03980	COG2755	lipolytic protein G-D-S-L family
S102022_RS03980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S102022_RS03985	COG2261	transglycosylase associated protein
S102022_RS04000	COG1302	Protein conserved in bacteria
S102022_RS04030	COG0308	aminopeptidase N
S102022_RS04055	COG0572	uridine kinase
S102022_RS04070	COG0583	DNA-binding transcription factor activity
S102022_RS04075	COG1053	succinate dehydrogenase
S102022_RS04085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S102022_RS04090	COG0017	Asparaginyl-tRNA synthetase
S102022_RS04095	COG2502	aspartate--ammonia ligase
S102022_RS04100	COG4690	dipeptidase activity
S102022_RS04120	COG0514	ATP-dependent DNA helicase (RecQ)
S102022_RS04125	COG0564	pseudouridine synthase activity
S102022_RS04130	COG0640	Transcriptional regulator
S102022_RS04180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S102022_RS04185	COG0527	aspartate kinase activity
S102022_RS04190	COG0367	asparagine synthase
S102022_RS04240	COG2814	Major facilitator Superfamily
S102022_RS04260	COG1278	Cold shock
S102022_RS04265	COG2966	Psort location CytoplasmicMembrane, score
S102022_RS04275	COG1316	TRANSCRIPTIONal
S102022_RS04295	COG1959	2 iron, 2 sulfur cluster binding
S102022_RS04300	COG0028	Belongs to the TPP enzyme family
S102022_RS04305	COG0833	amino acid
S102022_RS04315	COG1428	Deoxynucleoside kinase
S102022_RS04320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S102022_RS04360	COG4463	regulation of RNA biosynthetic process
S102022_RS04375	COG0085	RNA polymerase activity
S102022_RS04380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S102022_RS04385	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S102022_RS04390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S102022_RS04395	COG0049	tRNA binding
S102022_RS04400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S102022_RS04405	COG0051	transcription antitermination factor activity, RNA binding
S102022_RS04410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S102022_RS04415	COG0088	Forms part of the polypeptide exit tunnel
S102022_RS04420	COG0089	rRNA binding
S102022_RS04425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S102022_RS04430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S102022_RS04435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S102022_RS04440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S102022_RS04445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S102022_RS04450	COG0255	Belongs to the universal ribosomal protein uL29 family
S102022_RS04455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S102022_RS04460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S102022_RS04465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S102022_RS04470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S102022_RS04475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S102022_RS04480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S102022_RS04485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S102022_RS04490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S102022_RS04495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S102022_RS04500	COG1841	ribosomal large subunit assembly
S102022_RS04505	COG0200	Binds to the 23S rRNA
S102022_RS04515	COG0563	adenylate kinase activity
S102022_RS04520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S102022_RS04525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S102022_RS04530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S102022_RS04535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S102022_RS04540	COG0202	RNA polymerase activity
S102022_RS04545	COG0203	ribosomal protein L17
S102022_RS04580	COG4939	FMN-binding domain protein
S102022_RS04590	COG1122	ATPase activity
S102022_RS04595	COG1122	ATPase activity
S102022_RS04605	COG0101	tRNA pseudouridine synthase activity
S102022_RS04610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S102022_RS04615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S102022_RS04635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S102022_RS04640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S102022_RS04645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S102022_RS04650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S102022_RS04655	COG0471	metal ion transport
S102022_RS04660	COG2151	metal-sulfur cluster biosynthetic enzyme
S102022_RS04665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S102022_RS04675	COG1917	Cupin 2, conserved barrel domain protein
S102022_RS04675	COG4977	sequence-specific DNA binding
S102022_RS04680	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
S102022_RS04685	COG1121	(ABC) transporter
S102022_RS04690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S102022_RS04695	COG0803	Belongs to the bacterial solute-binding protein 9 family
S102022_RS04705	COG0039	L-malate dehydrogenase activity
S102022_RS04710	COG0471	metal ion transport
S102022_RS04730	COG3052	prosthetic group binding
S102022_RS04745	COG2826	transposase and inactivated derivatives, IS30 family
S102022_RS04770	COG0114	fumarate hydratase activity
S102022_RS04775	COG1053	succinate dehydrogenase
S102022_RS04785	COG0583	DNA-binding transcription factor activity
S102022_RS04790	COG0583	DNA-binding transcription factor activity
S102022_RS04795	COG0281	malic enzyme
S102022_RS04805	COG0531	amino acid
S102022_RS04810	COG4684	Psort location CytoplasmicMembrane, score
S102022_RS04825	COG1271	oxidase subunit
S102022_RS04830	COG1294	oxidase, subunit
S102022_RS04835	COG4988	ABC transporter
S102022_RS04840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S102022_RS04855	COG0142	geranyltranstransferase activity
S102022_RS04870	COG1705	Flagellar rod assembly protein muramidase FlgJ
S102022_RS04875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S102022_RS04880	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S102022_RS04885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S102022_RS04895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S102022_RS04900	COG4851	CamS sex pheromone cAM373 precursor
S102022_RS04905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S102022_RS04910	COG0154	amidase activity
S102022_RS04915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S102022_RS04920	COG1597	lipid kinase activity
S102022_RS04925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S102022_RS04940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS04950	COG1737	Transcriptional regulator
S102022_RS04965	COG1278	Cold shock
S102022_RS04970	COG0673	inositol 2-dehydrogenase activity
S102022_RS04975	COG0513	Belongs to the DEAD box helicase family
S102022_RS04990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS05015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S102022_RS05025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S102022_RS05035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS05055	COG2801	Transposase and inactivated derivatives
S102022_RS05070	COG0438	transferase activity, transferring glycosyl groups
S102022_RS05115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S102022_RS05125	COG1088	dTDP-glucose 4,6-dehydratase activity
S102022_RS05130	COG1091	dTDP-4-dehydrorhamnose reductase activity
S102022_RS05140	COG0582	viral genome integration into host DNA
S102022_RS05150	COG0489	protein tyrosine kinase activity
S102022_RS05155	COG4464	protein tyrosine phosphatase activity
S102022_RS05165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S102022_RS05185	COG1215	transferase activity, transferring glycosyl groups
S102022_RS05190	COG5039	Polysaccharide pyruvyl transferase
S102022_RS05225	COG0562	UDP-galactopyranose mutase
S102022_RS05260	COG1609	Transcriptional regulator
S102022_RS05260	COG2207	Transcriptional regulator
S102022_RS05280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S102022_RS05315	COG2137	regulation of response to DNA damage stimulus
S102022_RS05320	COG3557	Belongs to the UPF0374 family
S102022_RS05340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S102022_RS05350	COG0628	permease
S102022_RS05355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S102022_RS05360	COG2610	gluconate transmembrane transporter activity
S102022_RS05365	COG1070	Carbohydrate kinase
S102022_RS05370	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S102022_RS05375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S102022_RS05380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S102022_RS05415	COG4166	transmembrane transport
S102022_RS05420	COG0601	transmembrane transport
S102022_RS05425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S102022_RS05430	COG0444	Belongs to the ABC transporter superfamily
S102022_RS05435	COG4608	Belongs to the ABC transporter superfamily
S102022_RS05445	COG0582	viral genome integration into host DNA
S102022_RS05450	COG0542	response to heat
S102022_RS05470	COG0438	transferase activity, transferring glycosyl groups
S102022_RS05475	COG0438	transferase activity, transferring glycosyl groups
S102022_RS05485	COG1686	Belongs to the peptidase S11 family
S102022_RS05490	COG0436	Aminotransferase
S102022_RS05495	COG4703	Protein of unknown function (DUF1797)
S102022_RS05500	COG1368	sulfuric ester hydrolase activity
S102022_RS05590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S102022_RS05610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S102022_RS05630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S102022_RS05635	COG0833	amino acid
S102022_RS05640	COG2040	homocysteine
S102022_RS05645	COG0438	transferase activity, transferring glycosyl groups
S102022_RS05655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S102022_RS05660	COG0477	Major facilitator Superfamily
S102022_RS05675	COG0438	transferase activity, transferring glycosyl groups
S102022_RS05690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S102022_RS05700	COG0495	leucyl-tRNA aminoacylation
S102022_RS05705	COG2244	polysaccharide biosynthetic process
S102022_RS05710	COG1187	pseudouridine synthase activity
S102022_RS05715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S102022_RS05720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S102022_RS05730	COG3842	ATPase activity
S102022_RS05735	COG1175	transmembrane transport
S102022_RS05740	COG0395	ABC-type sugar transport system, permease component
S102022_RS05750	COG0584	glycerophosphoryl diester phosphodiesterase
S102022_RS05755	COG1428	Deoxynucleoside kinase
S102022_RS05760	COG1970	mechanosensitive ion channel activity
S102022_RS05765	COG1511	domain protein
S102022_RS05765	COG1511	domain protein
S102022_RS05790	COG2378	regulation of single-species biofilm formation
S102022_RS05795	COG0596	Alpha beta hydrolase
S102022_RS05805	COG0789	Transcriptional regulator
S102022_RS05825	COG0789	Transcriptional regulator
S102022_RS05835	COG0697	spore germination
S102022_RS05840	COG0561	phosphatase activity
S102022_RS05860	COG3279	Response regulator of the LytR AlgR family
S102022_RS05880	COG1846	Transcriptional regulator
S102022_RS05895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S102022_RS05935	COG0646	methionine synthase
S102022_RS05935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S102022_RS05940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S102022_RS05950	COG2046	Belongs to the sulfate adenylyltransferase family
S102022_RS05955	COG0529	Catalyzes the synthesis of activated sulfate
S102022_RS05960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S102022_RS05975	COG0534	Mate efflux family protein
S102022_RS05995	COG2153	protein acetylation
S102022_RS06000	COG0018	arginyl-trna synthetase
S102022_RS06010	COG1136	(ABC) transporter
S102022_RS06010	COG0577	efflux transmembrane transporter activity
S102022_RS06030	COG1447	Phosphotransferase system cellobiose-specific component IIA
S102022_RS06035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS06040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS06045	COG2723	6-phospho-beta-galactosidase activity
S102022_RS06055	COG1376	ErfK ybiS ycfS ynhG family protein
S102022_RS06060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S102022_RS06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S102022_RS06075	COG0436	Aminotransferase
S102022_RS06080	COG1438	arginine binding
S102022_RS06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S102022_RS06095	COG3679	Belongs to the UPF0342 family
S102022_RS06100	COG0420	3'-5' exonuclease activity
S102022_RS06105	COG4717	serine-type aminopeptidase activity
S102022_RS06110	COG3481	metal-dependent phosphohydrolase, HD sub domain
S102022_RS06125	COG0583	DNA-binding transcription factor activity
S102022_RS06140	COG3976	FMN-binding domain protein
S102022_RS06140	COG0431	NADPH-dependent FMN reductase
S102022_RS06140	COG1053	succinate dehydrogenase
S102022_RS06160	COG0463	Glycosyl transferase, family 2
S102022_RS06180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S102022_RS06180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S102022_RS06185	COG0307	riboflavin synthase, alpha
S102022_RS06190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S102022_RS06190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S102022_RS06195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S102022_RS06210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S102022_RS06220	COG0446	pyridine nucleotide-disulphide oxidoreductase
S102022_RS06250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S102022_RS06260	COG0537	adenosine 5'-monophosphoramidase activity
S102022_RS06265	COG1131	(ABC) transporter
S102022_RS06270	COG4473	ABC transporter
S102022_RS06275	COG0510	thiamine kinase activity
S102022_RS06280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S102022_RS06290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S102022_RS06295	COG1674	ftsk spoiiie
S102022_RS06300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S102022_RS06325	COG0719	Fe-S assembly protein
S102022_RS06330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S102022_RS06340	COG0719	Fe-S assembly protein
S102022_RS06345	COG2151	metal-sulfur cluster biosynthetic enzyme
S102022_RS06360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S102022_RS06360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S102022_RS06365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S102022_RS06370	COG0237	dephospho-CoA kinase activity
S102022_RS06375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S102022_RS06380	COG3611	Membrane attachment protein
S102022_RS06385	COG1484	DNA-dependent DNA replication
S102022_RS06390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S102022_RS06395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S102022_RS06400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S102022_RS06405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S102022_RS06415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S102022_RS06420	COG0604	alcohol dehydrogenase
S102022_RS06425	COG1733	regulation of RNA biosynthetic process
S102022_RS06435	COG1215	transferase activity, transferring glycosyl groups
S102022_RS06450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S102022_RS06455	COG1534	Rna-binding protein
S102022_RS06460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S102022_RS06465	COG1713	HD superfamily hydrolase involved in NAD metabolism
S102022_RS06470	COG0799	negative regulation of ribosome biogenesis
S102022_RS06475	COG2226	methyltransferase
S102022_RS06480	COG1323	Belongs to the UPF0348 family
S102022_RS06490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S102022_RS06505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S102022_RS06515	COG0745	RESPONSE REGULATOR receiver
S102022_RS06520	COG5002	protein histidine kinase activity
S102022_RS06535	COG0419	ATPase involved in DNA repair
S102022_RS06550	COG0706	membrane insertase activity
S102022_RS06555	COG1254	Belongs to the acylphosphatase family
S102022_RS06560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S102022_RS06570	COG1733	regulation of RNA biosynthetic process
S102022_RS06575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S102022_RS06580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S102022_RS06580	COG0072	phenylalanine-tRNA ligase activity
S102022_RS06585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S102022_RS06590	COG0572	uridine kinase
S102022_RS06595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S102022_RS06610	COG4841	protein insertion into membrane
S102022_RS06620	COG0768	penicillin binding
S102022_RS06625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S102022_RS06630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S102022_RS06635	COG0705	Rhomboid family
S102022_RS06635	COG0457	Tetratricopeptide repeat
S102022_RS06645	COG1940	carbohydrate kinase activity
S102022_RS06665	COG0584	glycerophosphoryl diester phosphodiesterase
S102022_RS06670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S102022_RS06675	COG0789	Transcriptional regulator
S102022_RS06725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S102022_RS06735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S102022_RS06740	COG0006	proline dipeptidase activity
S102022_RS06745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S102022_RS06750	COG1302	Protein conserved in bacteria
S102022_RS06755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S102022_RS06760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S102022_RS06765	COG1570	exodeoxyribonuclease VII activity
S102022_RS06770	COG1722	exodeoxyribonuclease VII activity
S102022_RS06775	COG0142	geranyltranstransferase activity
S102022_RS06780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S102022_RS06785	COG1438	arginine binding
S102022_RS06790	COG0497	DNA recombination
S102022_RS06805	COG1732	Glycine betaine
S102022_RS06830	COG0194	GDP metabolic process
S102022_RS06835	COG1758	RNA polymerase activity
S102022_RS06840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S102022_RS06845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S102022_RS06850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S102022_RS06855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S102022_RS06855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S102022_RS06860	COG0631	protein serine/threonine phosphatase activity
S102022_RS06865	COG2815	serine threonine protein kinase
S102022_RS06865	COG0515	serine threonine protein kinase
S102022_RS06870	COG1162	GTPase activity
S102022_RS06875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S102022_RS06880	COG1564	THIamine pyrophosphokinase
S102022_RS06885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S102022_RS06890	COG1302	Protein conserved in bacteria
S102022_RS06895	COG1461	Dihydroxyacetone kinase
S102022_RS06900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S102022_RS06905	COG0416	fatty acid biosynthetic process
S102022_RS06910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S102022_RS06915	COG0571	ribonuclease III activity
S102022_RS06920	COG1196	nuclear chromosome segregation
S102022_RS06925	COG0552	protein localization to endoplasmic reticulum
S102022_RS06930	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S102022_RS06935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S102022_RS06940	COG0228	four-way junction DNA binding
S102022_RS06945	COG1837	Belongs to the UPF0109 family
S102022_RS06950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S102022_RS06955	COG0336	Belongs to the RNA methyltransferase TrmD family
S102022_RS06960	COG0335	large ribosomal subunit rRNA binding
S102022_RS06980	COG1131	(ABC) transporter
S102022_RS07005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S102022_RS07010	COG0134	indole-3-glycerol-phosphate synthase activity
S102022_RS07015	COG0135	phosphoribosylanthranilate isomerase activity
S102022_RS07020	COG0133	tryptophan synthase activity
S102022_RS07025	COG0159	tryptophan synthase activity
S102022_RS07050	COG1473	amidohydrolase
S102022_RS07055	COG1063	alcohol dehydrogenase
S102022_RS07065	COG0300	oxidoreductase activity
S102022_RS07075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S102022_RS07080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S102022_RS07085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S102022_RS07090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S102022_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS07100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S102022_RS07115	COG0439	Biotin carboxylase
S102022_RS07130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S102022_RS07140	COG1811	Na channel or pump
S102022_RS07145	COG0583	DNA-binding transcription factor activity
S102022_RS07150	COG1607	acyl-coa hydrolase
S102022_RS07155	COG1162	GTPase activity
S102022_RS07165	COG0477	Major facilitator Superfamily
S102022_RS07215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S102022_RS07220	COG3397	chitin binding
S102022_RS07225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S102022_RS07235	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S102022_RS07245	COG3152	Membrane
S102022_RS07250	COG1597	lipid kinase activity
S102022_RS07265	COG2261	transglycosylase associated protein
S102022_RS07270	COG3237	CsbD-like
S102022_RS07285	COG1942	4-Oxalocrotonate Tautomerase
S102022_RS07325	COG0531	amino acid
S102022_RS07330	COG0561	phosphatase activity
S102022_RS07335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S102022_RS07335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
S102022_RS07365	COG2017	converts alpha-aldose to the beta-anomer
S102022_RS07370	COG1304	FMN binding
S102022_RS07395	COG1199	ATP-dependent helicase activity
S102022_RS07395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S102022_RS07410	COG0017	Asparaginyl-tRNA synthetase
S102022_RS07425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S102022_RS07430	COG2011	ABC-type metal ion transport system permease component
S102022_RS07435	COG1464	Belongs to the NlpA lipoprotein family
S102022_RS07450	COG1840	ABC-type Fe3 transport system, periplasmic component
S102022_RS07465	COG3331	DNA recombination
S102022_RS07470	COG4474	Belongs to the UPF0398 family
S102022_RS07475	COG3599	regulation of cell shape
S102022_RS07485	COG0116	Belongs to the methyltransferase superfamily
S102022_RS07495	COG0477	Major facilitator Superfamily
S102022_RS07500	COG1073	alpha beta
S102022_RS07510	COG1216	Glycosyl transferase, family 2
S102022_RS07530	COG1619	proteins homologs of microcin C7 resistance protein MccF
S102022_RS07560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S102022_RS07575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S102022_RS07580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S102022_RS07585	COG0564	pseudouridine synthase activity
S102022_RS07590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S102022_RS07595	COG0505	Belongs to the CarA family
S102022_RS07600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S102022_RS07610	COG5646	InterPro IPR014922
S102022_RS07635	COG1131	(ABC) transporter
S102022_RS07640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S102022_RS07645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S102022_RS07655	COG1307	EDD domain protein, DegV family
S102022_RS07715	COG1113	amino acid transport
S102022_RS07730	COG1620	l-lactate permease
S102022_RS07740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S102022_RS07750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S102022_RS07765	COG1846	Transcriptional regulator
S102022_RS07805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S102022_RS07810	COG1227	inorganic diphosphatase activity
S102022_RS07815	COG0583	DNA-binding transcription factor activity
S102022_RS07825	COG0187	DNA topoisomerase II activity
S102022_RS07830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S102022_RS07840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S102022_RS07845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S102022_RS07850	COG4974	Belongs to the 'phage' integrase family
S102022_RS07855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S102022_RS07860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S102022_RS07865	COG0758	DNA mediated transformation
S102022_RS07870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S102022_RS07875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S102022_RS07885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S102022_RS07890	COG0583	DNA-binding transcription factor activity
S102022_RS07925	COG2814	Major facilitator Superfamily
S102022_RS07930	COG0793	Belongs to the peptidase S41A family
S102022_RS07930	COG3409	Peptidoglycan-binding domain 1 protein
S102022_RS07935	COG4479	Belongs to the UPF0346 family
S102022_RS07940	COG4698	Protein conserved in bacteria
S102022_RS07945	COG2755	lipolytic protein G-D-S-L family
S102022_RS07950	COG1307	EDD domain protein, DegV family
S102022_RS07955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S102022_RS07960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S102022_RS07965	COG0488	(ABC) transporter
S102022_RS07975	COG0617	tRNA 3'-terminal CCA addition
S102022_RS07980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S102022_RS07985	COG0561	phosphatase activity
S102022_RS07990	COG0457	Tetratricopeptide repeat
S102022_RS08005	COG1160	GTP binding
S102022_RS08010	COG0539	negative regulation of cytoplasmic translation
S102022_RS08015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S102022_RS08025	COG0514	ATP-dependent DNA helicase (RecQ)
S102022_RS08040	COG1187	pseudouridine synthase activity
S102022_RS08045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S102022_RS08050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S102022_RS08060	COG4974	Belongs to the 'phage' integrase family
S102022_RS08065	COG2996	Protein conserved in bacteria
S102022_RS08085	COG0205	6-phosphofructokinase activity
S102022_RS08090	COG0587	DNA-directed DNA polymerase activity
S102022_RS08100	COG0542	response to heat
S102022_RS08110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S102022_RS08115	COG2384	SAM-dependent methyltransferase
S102022_RS08140	COG0574	Belongs to the PEP-utilizing enzyme family
S102022_RS08140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S102022_RS08150	COG1846	Transcriptional regulator
S102022_RS08170	COG2217	Heavy metal translocating P-type atpase
S102022_RS08180	COG0477	Major facilitator Superfamily
S102022_RS08190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S102022_RS08200	COG1349	DNA-binding transcription factor activity
S102022_RS08215	COG1393	Belongs to the ArsC family
S102022_RS08235	COG0546	phosphoglycolate phosphatase activity
S102022_RS08265	COG0583	DNA-binding transcription factor activity
S102022_RS08270	COG0604	alcohol dehydrogenase
S102022_RS08280	COG0446	pyridine nucleotide-disulphide oxidoreductase
S102022_RS08285	COG2197	response regulator
S102022_RS08290	COG4585	Histidine kinase
S102022_RS08300	COG1131	(ABC) transporter
S102022_RS08310	COG0519	Catalyzes the synthesis of GMP from XMP
S102022_RS08340	COG1131	(ABC) transporter
S102022_RS08360	COG1131	(ABC) transporter
S102022_RS08365	COG1725	Transcriptional regulator
S102022_RS08375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S102022_RS08380	COG0358	DNA primase activity
S102022_RS08385	COG0751	glycine-tRNA ligase activity
S102022_RS08390	COG0752	glycyl-tRNA synthetase alpha subunit
S102022_RS08395	COG1381	Involved in DNA repair and RecF pathway recombination
S102022_RS08400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S102022_RS08405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S102022_RS08410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S102022_RS08415	COG1702	phosphate starvation-inducible protein PhoH
S102022_RS08420	COG1610	YqeY-like protein
S102022_RS08425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S102022_RS08430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S102022_RS08440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S102022_RS08450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S102022_RS08460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S102022_RS08465	COG0124	histidyl-tRNA synthetase
S102022_RS08470	COG4991	sh3 domain protein
S102022_RS08470	COG0860	N-Acetylmuramoyl-L-alanine amidase
S102022_RS08470	COG3103	Sh3 type 3 domain protein
S102022_RS08475	COG3001	Fructosamine kinase
S102022_RS08480	COG0546	phosphoglycolate phosphatase activity
S102022_RS08485	COG1490	D-aminoacyl-tRNA deacylase activity
S102022_RS08490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S102022_RS08500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S102022_RS08505	COG2264	protein methyltransferase activity
S102022_RS08510	COG2094	Belongs to the DNA glycosylase MPG family
S102022_RS08525	COG0481	GTPase activity
S102022_RS08530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S102022_RS08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S102022_RS08540	COG1696	Membrane protein involved in D-alanine export
S102022_RS08545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S102022_RS08555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S102022_RS08560	COG0484	heat shock protein binding
S102022_RS08565	COG0443	Heat shock 70 kDa protein
S102022_RS08570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S102022_RS08575	COG1420	regulation of RNA biosynthetic process
S102022_RS08580	COG3527	Alpha-acetolactate decarboxylase
S102022_RS08585	COG0196	riboflavin kinase activity
S102022_RS08590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S102022_RS08595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S102022_RS08600	COG0287	Prephenate dehydrogenase
S102022_RS08605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S102022_RS08615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S102022_RS08620	COG0738	Major facilitator superfamily
S102022_RS08625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S102022_RS08630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S102022_RS08640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S102022_RS08645	COG0195	Participates in both transcription termination and antitermination
S102022_RS08650	COG0779	Required for maturation of 30S ribosomal subunits
S102022_RS08655	COG2176	DNA-directed DNA polymerase activity
S102022_RS08660	COG0442	prolyl-tRNA aminoacylation
S102022_RS08665	COG0750	zinc metalloprotease
S102022_RS08670	COG4589	Belongs to the CDS family
S102022_RS08675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S102022_RS08680	COG0233	cytoplasmic translational termination
S102022_RS08685	COG0528	UMP kinase activity
S102022_RS08690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S102022_RS08695	COG0052	Belongs to the universal ribosomal protein uS2 family
S102022_RS08705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S102022_RS08710	COG2827	Endonuclease containing a URI domain
S102022_RS08715	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S102022_RS08720	COG0204	Acyl-transferase
S102022_RS08725	COG3763	UPF0154 protein
S102022_RS08730	COG4224	UPF0291 protein
S102022_RS08735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S102022_RS08750	COG3425	synthase
S102022_RS08765	COG0463	Glycosyl transferase, family 2
S102022_RS08775	COG1316	TRANSCRIPTIONal
S102022_RS08780	COG1116	anion transmembrane transporter activity
S102022_RS08790	COG0772	Belongs to the SEDS family
S102022_RS09080	COG0393	Putative heavy-metal-binding
S102022_RS09095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S102022_RS09100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S102022_RS09100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S102022_RS09105	COG5416	Lipopolysaccharide assembly protein A domain
S102022_RS09110	COG0300	oxidoreductase activity
S102022_RS09115	COG1234	tRNA 3'-trailer cleavage
S102022_RS09125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S102022_RS09130	COG1349	DNA-binding transcription factor activity
S102022_RS09135	COG1105	Belongs to the carbohydrate kinase PfkB family
S102022_RS09140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS09140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS09140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS09145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S102022_RS09170	COG0297	glycogen (starch) synthase activity
S102022_RS09175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S102022_RS09180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S102022_RS09190	COG0489	protein tyrosine kinase activity
S102022_RS09200	COG0322	excinuclease ABC activity
S102022_RS09205	COG1126	abc transporter atp-binding protein
S102022_RS09210	COG0765	amino acid transport
S102022_RS09230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S102022_RS09235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S102022_RS09240	COG0544	peptidyl-prolyl cis-trans isomerase activity
S102022_RS09245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S102022_RS09270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S102022_RS09275	COG0268	Binds directly to 16S ribosomal RNA
S102022_RS09280	COG1466	dna polymerase III delta subunit
S102022_RS09285	COG2333	competence protein COMEC
S102022_RS09285	COG0658	competence protein
S102022_RS09290	COG2131	deaminase
S102022_RS09295	COG1555	photosystem II stabilization
S102022_RS09295	COG1596	polysaccharide export
S102022_RS09300	COG3480	Lon protease (S16) C-terminal proteolytic domain
S102022_RS09305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S102022_RS09310	COG0742	ribosomal rna small subunit methyltransferase
S102022_RS09315	COG4471	UPF0298 protein
S102022_RS09320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S102022_RS09325	COG0772	Belongs to the SEDS family
S102022_RS09360	COG1217	gtp-binding protein TYPA
S102022_RS09365	COG0483	inositol monophosphate 1-phosphatase activity
S102022_RS09370	COG4476	Belongs to the UPF0223 family
S102022_RS09375	COG0039	L-malate dehydrogenase activity
S102022_RS09400	COG0242	peptide deformylase activity
S102022_RS09410	COG5503	Protein of unknown function (DUF1447)
S102022_RS09415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S102022_RS09420	COG1597	lipid kinase activity
S102022_RS09430	COG1388	LysM domain
S102022_RS09430	COG3584	3D domain protein
S102022_RS09435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S102022_RS09440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S102022_RS09475	COG0569	domain protein
S102022_RS09480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S102022_RS09485	COG0482	sulfurtransferase activity
S102022_RS09495	COG1104	cysteine desulfurase activity
S102022_RS09500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S102022_RS09510	COG0494	nUDIX hydrolase
S102022_RS09515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S102022_RS09520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S102022_RS09525	COG3599	regulation of cell shape
S102022_RS09535	COG0762	integral membrane protein
S102022_RS09540	COG1799	cell septum assembly
S102022_RS09555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S102022_RS09560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S102022_RS09565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S102022_RS09570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S102022_RS09575	COG0768	penicillin binding
S102022_RS09585	COG0275	rRNA processing
S102022_RS09590	COG2001	Belongs to the MraZ family
S102022_RS09610	COG1674	ftsk spoiiie
S102022_RS09615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S102022_RS09625	COG1114	Component of the transport system for branched-chain amino acids
S102022_RS09640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S102022_RS09645	COG0628	permease
S102022_RS09655	COG2706	6-phosphogluconolactonase activity
S102022_RS09660	COG3142	Participates in the control of copper homeostasis
S102022_RS09665	COG0564	pseudouridine synthase activity
S102022_RS09670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S102022_RS09675	COG2357	RelA SpoT domain protein
S102022_RS09685	COG1164	Oligoendopeptidase f
S102022_RS09695	COG4862	establishment of competence for transformation
S102022_RS09700	COG1393	Belongs to the ArsC family
S102022_RS09705	COG1234	tRNA 3'-trailer cleavage
S102022_RS09845	COG1098	S1 RNA binding domain
S102022_RS09855	COG0586	Pfam SNARE associated Golgi protein
S102022_RS09865	COG0647	UMP catabolic process
S102022_RS09870	COG4470	Protein conserved in bacteria
S102022_RS09875	COG0737	Belongs to the 5'-nucleotidase family
S102022_RS09890	COG1113	amino acid transport
S102022_RS09895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S102022_RS09900	COG0827	DNA restriction-modification system
S102022_RS09930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S102022_RS09940	COG0217	transcriptional regulatory protein
S102022_RS09955	COG1609	Transcriptional regulator
S102022_RS09960	COG0006	proline dipeptidase activity
S102022_RS09965	COG0789	Transcriptional regulator
S102022_RS09980	COG0668	transmembrane transport
S102022_RS09985	COG1473	amidohydrolase
S102022_RS09990	COG2171	N-acyltransferase activity
S102022_RS09995	COG0517	IMP dehydrogenase activity
S102022_RS10005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S102022_RS10010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S102022_RS10015	COG1719	4-vinyl reductase, 4VR
S102022_RS10020	COG3118	belongs to the thioredoxin family
S102022_RS10025	COG1193	negative regulation of DNA recombination
S102022_RS10035	COG3906	Belongs to the UPF0473 family
S102022_RS10040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S102022_RS10045	COG4472	Bacterial protein of unknown function (DUF965)
S102022_RS10050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S102022_RS10055	COG0513	Belongs to the DEAD box helicase family
S102022_RS10060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S102022_RS10065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S102022_RS10070	COG1862	Preprotein translocase
S102022_RS10075	COG0343	queuine tRNA-ribosyltransferase activity
S102022_RS10080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S102022_RS10085	COG2255	four-way junction helicase activity
S102022_RS10090	COG0632	four-way junction helicase activity
S102022_RS10120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S102022_RS10125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S102022_RS10130	COG1692	metallophosphoesterase
S102022_RS10135	COG1418	mRNA catabolic process
S102022_RS10140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S102022_RS10145	COG1058	Belongs to the CinA family
S102022_RS10145	COG1546	Belongs to the CinA family
S102022_RS10150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S102022_RS10155	COG1426	Protein conserved in bacteria
S102022_RS10160	COG0612	Peptidase, M16
S102022_RS10165	COG0612	Peptidase, M16
S102022_RS10170	COG0527	aspartate kinase activity
S102022_RS10185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S102022_RS10190	COG1126	abc transporter atp-binding protein
S102022_RS10195	COG0765	amino acid transport
S102022_RS10200	COG2894	cell division
S102022_RS10205	COG0850	regulation of cytokinetic process
S102022_RS10215	COG1792	Involved in formation and maintenance of cell shape
S102022_RS10220	COG1077	Cell shape determining protein MreB Mrl
S102022_RS10225	COG2003	Belongs to the UPF0758 family
S102022_RS10230	COG0285	dihydrofolate synthase activity
S102022_RS10235	COG0525	valine-tRNA ligase activity
S102022_RS10245	COG1181	Belongs to the D-alanine--D-alanine ligase family
S102022_RS10245	COG2918	glutathione biosynthetic process
S102022_RS10250	COG0301	tRNA thio-modification
S102022_RS10255	COG1104	cysteine desulfurase activity
S102022_RS10265	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S102022_RS10270	COG1956	GAF domain-containing protein
S102022_RS10275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S102022_RS10280	COG4493	Belongs to the UPF0637 family
S102022_RS10295	COG0640	Transcriptional regulator
S102022_RS10300	COG0366	Alpha amylase catalytic
S102022_RS10310	COG3716	PTS system mannose fructose sorbose family IID component
S102022_RS10315	COG3715	PTS system
S102022_RS10320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS10325	COG1609	Transcriptional regulator
S102022_RS10335	COG0189	ligase activity
S102022_RS10335	COG2918	glutathione biosynthetic process
S102022_RS10340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S102022_RS10355	COG0589	response to stress
S102022_RS10375	COG1181	Belongs to the D-alanine--D-alanine ligase family
S102022_RS10395	COG1464	Belongs to the NlpA lipoprotein family
S102022_RS10400	COG2011	ABC-type metal ion transport system permease component
S102022_RS10405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S102022_RS10410	COG0509	glycine decarboxylation via glycine cleavage system
S102022_RS10415	COG0772	Belongs to the SEDS family
S102022_RS10425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S102022_RS10430	COG1077	Cell shape determining protein MreB Mrl
S102022_RS10440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S102022_RS10445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S102022_RS10450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S102022_RS10455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S102022_RS10460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S102022_RS10465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S102022_RS10470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S102022_RS10475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S102022_RS10480	COG0356	it plays a direct role in the translocation of protons across the membrane
S102022_RS10485	COG2233	PERMEase
S102022_RS10495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S102022_RS10500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S102022_RS10505	COG0009	L-threonylcarbamoyladenylate synthase
S102022_RS10510	COG2890	protein-(glutamine-N5) methyltransferase activity
S102022_RS10515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S102022_RS10520	COG1435	thymidine kinase activity
S102022_RS10525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S102022_RS10530	COG3442	glutamine amidotransferase
S102022_RS10535	COG1482	cell wall glycoprotein biosynthetic process
S102022_RS10540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S102022_RS10550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S102022_RS10570	COG1132	(ABC) transporter
S102022_RS10585	COG0726	polysaccharide deacetylase
S102022_RS10930	COG4932	domain protein
S102022_RS10930	COG4886	Leucine-rich repeat (LRR) protein
S102022_RS10975	COG1132	(ABC) transporter
S102022_RS10985	COG0577	efflux transmembrane transporter activity
S102022_RS10985	COG1136	(ABC) transporter
S102022_RS10995	COG0166	Belongs to the GPI family
S102022_RS11000	COG4975	Glucose uptake
S102022_RS11005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S102022_RS11010	COG5002	protein histidine kinase activity
S102022_RS11010	COG3850	Histidine kinase
S102022_RS11015	COG0745	RESPONSE REGULATOR receiver
S102022_RS11020	COG2848	UPF0210 protein
S102022_RS11025	COG3830	Belongs to the UPF0237 family
S102022_RS11030	COG0697	spore germination
S102022_RS11050	COG0477	Major facilitator Superfamily
S102022_RS11070	COG0791	NLP P60 protein
S102022_RS11075	COG1522	sequence-specific DNA binding
S102022_RS11100	COG0488	(ABC) transporter
S102022_RS11130	COG2190	(PTS) system
S102022_RS11130	COG1263	PTS System
S102022_RS11130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS11135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S102022_RS11140	COG1307	EDD domain protein, DegV family
S102022_RS11150	COG2873	o-acetylhomoserine
S102022_RS11155	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S102022_RS11170	COG4120	Belongs to the binding-protein-dependent transport system permease family
S102022_RS11180	COG0446	pyridine nucleotide-disulphide oxidoreductase
S102022_RS11185	COG2084	Dehydrogenase
S102022_RS11190	COG0861	Integral membrane protein TerC family
S102022_RS11195	COG0110	maltose O-acetyltransferase activity
S102022_RS11200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S102022_RS11205	COG0140	phosphoribosyl-ATP diphosphatase activity
S102022_RS11210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S102022_RS11215	COG0107	imidazoleglycerol-phosphate synthase activity
S102022_RS11220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S102022_RS11225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S102022_RS11230	COG0131	Imidazoleglycerol-phosphate dehydratase
S102022_RS11235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S102022_RS11240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S102022_RS11245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S102022_RS11250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S102022_RS11270	COG0789	Transcriptional regulator
S102022_RS11275	COG0300	oxidoreductase activity
S102022_RS11285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S102022_RS11300	COG3548	integral membrane protein
S102022_RS11320	COG1368	sulfuric ester hydrolase activity
S102022_RS11325	COG0584	glycerophosphoryl diester phosphodiesterase
S102022_RS11335	COG0492	ferredoxin-NADP+ reductase activity
S102022_RS11345	COG4932	domain protein
S102022_RS11350	COG2326	polyphosphate kinase activity
S102022_RS11355	COG0778	Nitroreductase
S102022_RS11365	COG0328	RNA-DNA hybrid ribonuclease activity
S102022_RS11375	COG1609	Transcriptional regulator
S102022_RS11385	COG0673	inositol 2-dehydrogenase activity
S102022_RS11390	COG0673	inositol 2-dehydrogenase activity
S102022_RS11395	COG0025	NhaP-type Na H and K H
S102022_RS11400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S102022_RS11405	COG1335	isochorismatase
S102022_RS11415	COG1131	(ABC) transporter
S102022_RS11420	COG1725	Transcriptional regulator
S102022_RS11465	COG0028	Belongs to the TPP enzyme family
S102022_RS11475	COG1073	alpha beta
S102022_RS11480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S102022_RS11485	COG0626	cystathionine gamma-synthase activity
S102022_RS11515	COG0095	Lipoate-protein ligase
S102022_RS11520	COG1705	Flagellar rod assembly protein muramidase FlgJ
S102022_RS11525	COG0589	response to stress
S102022_RS11530	COG0564	pseudouridine synthase activity
S102022_RS11545	COG4640	response to antibiotic
S102022_RS11550	COG1396	sequence-specific DNA binding
S102022_RS11565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S102022_RS11575	COG2188	Transcriptional regulator
S102022_RS11580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S102022_RS11590	COG1418	mRNA catabolic process
S102022_RS11620	COG1253	flavin adenine dinucleotide binding
S102022_RS11625	COG1780	Probably involved in ribonucleotide reductase function
S102022_RS11630	COG0025	NhaP-type Na H and K H
S102022_RS11635	COG2814	Major facilitator Superfamily
S102022_RS11640	COG0789	Transcriptional regulator
S102022_RS11645	COG0604	alcohol dehydrogenase
S102022_RS11655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S102022_RS11665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S102022_RS11670	COG0436	Aminotransferase
S102022_RS11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S102022_RS11690	COG0583	DNA-binding transcription factor activity
S102022_RS11695	COG0702	epimerase
S102022_RS11705	COG1074	ATP-dependent DNA helicase activity
S102022_RS11710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S102022_RS11720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S102022_RS11725	COG0284	orotidine-5'-phosphate decarboxylase activity
S102022_RS11730	COG0167	dihydroorotate dehydrogenase activity
S102022_RS11735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S102022_RS11740	COG0505	Belongs to the CarA family
S102022_RS11745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S102022_RS11750	COG0540	Belongs to the ATCase OTCase family
S102022_RS11755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S102022_RS11760	COG2508	Transcriptional regulator
S102022_RS11765	COG2233	PERMEase
S102022_RS11770	COG2252	PERMEase
S102022_RS11790	COG1215	transferase activity, transferring glycosyl groups
S102022_RS11800	COG0151	Belongs to the GarS family
S102022_RS11805	COG0138	bifunctional purine biosynthesis protein purh
S102022_RS11810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S102022_RS11815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S102022_RS11825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S102022_RS11830	COG0047	phosphoribosylformylglycinamidine synthase activity
S102022_RS11835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S102022_RS11840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S102022_RS11845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S102022_RS11855	COG0431	NADPH-dependent FMN reductase
S102022_RS11855	COG3976	FMN-binding domain protein
S102022_RS11855	COG1053	succinate dehydrogenase
S102022_RS11860	COG0431	NADPH-dependent FMN reductase
S102022_RS11860	COG3976	FMN-binding domain protein
S102022_RS11860	COG1053	succinate dehydrogenase
S102022_RS11865	COG0095	Lipoate-protein ligase
S102022_RS11870	COG2365	Tyrosine phosphatase family
S102022_RS11890	COG1136	(ABC) transporter
S102022_RS11905	COG1725	Transcriptional regulator
S102022_RS11910	COG1131	(ABC) transporter
S102022_RS11920	COG0589	response to stress
S102022_RS11930	COG2246	polysaccharide biosynthetic process
S102022_RS11950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S102022_RS11970	COG0366	Alpha amylase catalytic
S102022_RS11980	COG0561	phosphatase activity
S102022_RS11990	COG0110	maltose O-acetyltransferase activity
S102022_RS11995	COG0494	nUDIX hydrolase
S102022_RS12060	COG1827	regulation of RNA biosynthetic process
S102022_RS12065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S102022_RS12070	COG1309	transcriptional regulator
S102022_RS12080	COG1131	(ABC) transporter
S102022_RS12085	COG3048	D-serine ammonia-lyase activity
S102022_RS12090	COG2723	6-phospho-beta-galactosidase activity
S102022_RS12095	COG2723	6-phospho-beta-galactosidase activity
S102022_RS12100	COG1447	Phosphotransferase system cellobiose-specific component IIA
S102022_RS12105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS12110	COG2188	Transcriptional regulator
S102022_RS12115	COG1216	Glycosyl transferase, family 2
S102022_RS12130	COG0561	phosphatase activity
S102022_RS12135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S102022_RS12160	COG0716	FMN binding
S102022_RS12180	COG0710	3-dehydroquinate dehydratase activity
S102022_RS12185	COG0531	amino acid
S102022_RS12230	COG4720	Psort location CytoplasmicMembrane, score
S102022_RS12235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S102022_RS12250	COG4990	cell redox homeostasis
S102022_RS12270	COG1811	Na channel or pump
S102022_RS12275	COG4978	Transcriptional regulator
S102022_RS12275	COG0789	Transcriptional regulator
S102022_RS12290	COG0577	efflux transmembrane transporter activity
S102022_RS12295	COG1136	(ABC) transporter
S102022_RS12335	COG2814	Major facilitator Superfamily
S102022_RS12355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S102022_RS12360	COG2855	membrane
S102022_RS12365	COG0583	DNA-binding transcription factor activity
S102022_RS12375	COG0438	transferase activity, transferring glycosyl groups
S102022_RS12390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S102022_RS12405	COG4152	abc transporter atp-binding protein
S102022_RS12415	COG4221	oxidoreductase activity
S102022_RS12430	COG0789	Transcriptional regulator
S102022_RS12450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S102022_RS12475	COG0456	acetyltransferase
S102022_RS12500	COG0583	DNA-binding transcription factor activity
S102022_RS12510	COG1063	alcohol dehydrogenase
S102022_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS12525	COG0589	response to stress
S102022_RS12530	COG0110	maltose O-acetyltransferase activity
S102022_RS12535	COG1011	Hydrolase
S102022_RS12560	COG0667	Aldo Keto reductase
S102022_RS12565	COG1132	(ABC) transporter
S102022_RS12570	COG1132	(ABC) transporter
S102022_RS12575	COG2814	Major facilitator Superfamily
S102022_RS12590	COG1511	domain protein
S102022_RS12590	COG1511	domain protein
S102022_RS12600	COG0640	Transcriptional regulator
S102022_RS12630	COG0488	(ABC) transporter
S102022_RS12635	COG0561	phosphatase activity
S102022_RS12645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S102022_RS12660	COG2270	Major facilitator Superfamily
S102022_RS12700	COG2200	EAL domain
S102022_RS12710	COG1328	CTP reductase activity
S102022_RS12720	COG0242	peptide deformylase activity
S102022_RS12730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S102022_RS12750	COG0583	DNA-binding transcription factor activity
S102022_RS12760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S102022_RS12820	COG0697	spore germination
S102022_RS12845	COG1940	carbohydrate kinase activity
S102022_RS12850	COG1132	(ABC) transporter
S102022_RS12860	COG0778	Nitroreductase
S102022_RS12865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS12865	COG2190	(PTS) system
S102022_RS12865	COG1263	PTS System
S102022_RS12870	COG1116	anion transmembrane transporter activity
S102022_RS12875	COG4120	Belongs to the binding-protein-dependent transport system permease family
S102022_RS12905	COG0617	tRNA 3'-terminal CCA addition
S102022_RS12905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S102022_RS12905	COG3620	sequence-specific DNA binding
S102022_RS12910	COG0410	ABC transporter
S102022_RS12925	COG0559	Belongs to the binding-protein-dependent transport system permease family
S102022_RS12940	COG5549	protein import
S102022_RS12940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S102022_RS12945	COG2246	polysaccharide biosynthetic process
S102022_RS12955	COG1914	H( )-stimulated, divalent metal cation uptake system
S102022_RS12975	COG0640	Transcriptional regulator
S102022_RS12985	COG0577	efflux transmembrane transporter activity
S102022_RS12985	COG1136	(ABC) transporter
S102022_RS13020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS13025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS13030	COG2723	6-phospho-beta-galactosidase activity
S102022_RS13040	COG0789	Transcriptional regulator
S102022_RS13045	COG0741	lytic transglycosylase activity
S102022_RS13065	COG0803	Belongs to the bacterial solute-binding protein 9 family
S102022_RS13090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S102022_RS13105	COG0789	Transcriptional regulator
S102022_RS13120	COG0667	Aldo Keto reductase
S102022_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS13145	COG1073	alpha beta
S102022_RS13165	COG4221	oxidoreductase activity
S102022_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS13210	COG1132	(ABC) transporter
S102022_RS13215	COG1132	(ABC) transporter
S102022_RS13220	COG1473	amidohydrolase
S102022_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS13240	COG0531	amino acid
S102022_RS13270	COG2217	Heavy metal translocating P-type atpase
S102022_RS13330	COG1063	alcohol dehydrogenase
S102022_RS13370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S102022_RS13385	COG1733	regulation of RNA biosynthetic process
S102022_RS13390	COG2814	Major facilitator Superfamily
S102022_RS13400	COG0367	asparagine synthase
S102022_RS13405	COG3279	Response regulator of the LytR AlgR family
S102022_RS13420	COG1309	transcriptional regulator
S102022_RS13430	COG1012	belongs to the aldehyde dehydrogenase family
S102022_RS13445	COG1733	regulation of RNA biosynthetic process
S102022_RS13450	COG0300	oxidoreductase activity
S102022_RS13470	COG4989	oxidoreductase activity
S102022_RS13475	COG0477	Major facilitator Superfamily
S102022_RS13485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S102022_RS13490	COG1120	ATPase activity
S102022_RS13495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S102022_RS13500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S102022_RS13505	COG1309	transcriptional regulator
S102022_RS13515	COG4221	oxidoreductase activity
S102022_RS13520	COG0110	maltose O-acetyltransferase activity
S102022_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
S102022_RS13560	COG0481	GTPase activity
S102022_RS13570	COG2816	NAD+ diphosphatase activity
S102022_RS13580	COG1053	succinate dehydrogenase
S102022_RS13590	COG0783	Belongs to the Dps family
S102022_RS13600	COG2723	6-phospho-beta-galactosidase activity
S102022_RS13605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS13625	COG0789	Transcriptional regulator
S102022_RS13645	COG0693	protein deglycase activity
S102022_RS13670	COG0577	efflux transmembrane transporter activity
S102022_RS13670	COG1136	(ABC) transporter
S102022_RS13680	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S102022_RS13715	COG0588	phosphoglycerate mutase activity
S102022_RS13720	COG0628	permease
S102022_RS13725	COG1846	Transcriptional regulator
S102022_RS13725	COG1940	carbohydrate kinase activity
S102022_RS13735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S102022_RS13745	COG0515	serine threonine protein kinase
S102022_RS13745	COG2815	serine threonine protein kinase
S102022_RS13785	COG1247	-acetyltransferase
S102022_RS13790	COG1686	Belongs to the peptidase S11 family
S102022_RS13810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S102022_RS13815	COG0517	IMP dehydrogenase activity
S102022_RS13815	COG0516	GMP reductase activity
S102022_RS13825	COG0012	GTP binding
S102022_RS13830	COG4481	Protein conserved in bacteria
S102022_RS13835	COG1475	DNA binding
S102022_RS13840	COG1192	Involved in chromosome partitioning
S102022_RS13850	COG0357	Ribosomal RNA small subunit methyltransferase G
S102022_RS13855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S102022_RS13870	COG0583	DNA-binding transcription factor activity
S102022_RS13875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S102022_RS13880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S102022_RS13885	COG0765	amino acid transport
S102022_RS13890	COG1126	abc transporter atp-binding protein
S102022_RS13895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S102022_RS13920	COG2190	(PTS) system
S102022_RS13920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS13920	COG1263	PTS System
S102022_RS13925	COG0366	Alpha amylase catalytic
S102022_RS13930	COG1609	Transcriptional regulator
S102022_RS13945	COG0390	transport system, permease component
S102022_RS13950	COG4619	ABC transporter
S102022_RS13955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S102022_RS13970	COG0561	phosphatase activity
S102022_RS13985	COG2190	(PTS) system
S102022_RS13985	COG1263	PTS System
S102022_RS13985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS14015	COG0735	belongs to the Fur family
S102022_RS14040	COG1380	Effector of murein hydrolase LrgA
S102022_RS14050	COG1307	EDD domain protein, DegV family
S102022_RS14060	COG2738	Putative neutral zinc metallopeptidase
S102022_RS14065	COG1233	COG1233 Phytoene dehydrogenase and related
S102022_RS14070	COG1562	ergosterol biosynthetic process
S102022_RS14080	COG1929	Belongs to the glycerate kinase type-1 family
S102022_RS14095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S102022_RS14100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S102022_RS14105	COG0516	GMP reductase activity
S102022_RS14110	COG2365	Tyrosine phosphatase family
S102022_RS14115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S102022_RS14125	COG1511	domain protein
S102022_RS14140	COG0531	amino acid
S102022_RS14145	COG3158	transport of potassium into the cell
S102022_RS14150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S102022_RS14155	COG0628	permease
S102022_RS14160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S102022_RS14175	COG1272	protein, Hemolysin III
S102022_RS14180	COG0640	Transcriptional regulator
S102022_RS14220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S102022_RS14230	COG0302	gtp cyclohydrolase
S102022_RS14235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S102022_RS14255	COG0803	Belongs to the bacterial solute-binding protein 9 family
S102022_RS14260	COG2814	Major facilitator Superfamily
S102022_RS14290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S102022_RS14295	COG1882	Formate acetyltransferase
S102022_RS14300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S102022_RS14310	COG2151	metal-sulfur cluster biosynthetic enzyme
S102022_RS14315	COG4989	oxidoreductase activity
S102022_RS14350	COG2217	Heavy metal translocating P-type atpase
S102022_RS14360	COG2315	Protein conserved in bacteria
S102022_RS14370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S102022_RS14375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S102022_RS14385	COG1757	Na H antiporter
S102022_RS14390	COG1113	amino acid transport
S102022_RS14400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S102022_RS14415	COG1393	Belongs to the ArsC family
S102022_RS14420	COG3189	MarR family transcriptional regulator
S102022_RS14430	COG1194	a g-specific adenine glycosylase
S102022_RS14445	COG0071	Belongs to the small heat shock protein (HSP20) family
S102022_RS14470	COG0697	spore germination
S102022_RS14485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S102022_RS14510	COG0477	Major facilitator Superfamily
S102022_RS14575	COG0737	Belongs to the 5'-nucleotidase family
S102022_RS14585	COG0656	L-ascorbic acid biosynthetic process
S102022_RS14605	COG1968	undecaprenyl-diphosphatase activity
S102022_RS14610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S102022_RS14645	COG2207	Transcriptional regulator
S102022_RS14670	COG0076	glutamate decarboxylase activity
S102022_RS14715	COG1309	transcriptional regulator
S102022_RS14725	COG2226	methyltransferase
S102022_RS14745	COG2217	Heavy metal translocating P-type atpase
S102022_RS14750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS14755	COG3118	belongs to the thioredoxin family
S102022_RS14760	COG1937	Protein conserved in bacteria
S102022_RS14780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S102022_RS14785	COG3590	peptidase
S102022_RS14805	COG0446	pyridine nucleotide-disulphide oxidoreductase
S102022_RS14855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S102022_RS14865	COG1114	Component of the transport system for branched-chain amino acids
S102022_RS14875	COG1874	Beta-galactosidase
S102022_RS14880	COG1609	Transcriptional regulator
S102022_RS14890	COG0477	Major facilitator Superfamily
S102022_RS14910	COG2184	nucleotidyltransferase activity
S102022_RS14915	COG2944	sequence-specific DNA binding
S102022_RS14920	COG1609	Transcriptional regulator
S102022_RS14925	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S102022_RS14930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S102022_RS14935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S102022_RS14955	COG2190	(PTS) system
S102022_RS14955	COG2211	Major facilitator Superfamily
S102022_RS14960	COG2017	converts alpha-aldose to the beta-anomer
S102022_RS14965	COG1609	Transcriptional regulator
S102022_RS14990	COG0710	3-dehydroquinate dehydratase activity
S102022_RS14995	COG0738	Major facilitator superfamily
S102022_RS15000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S102022_RS15005	COG0583	DNA-binding transcription factor activity
S102022_RS15010	COG0738	Major facilitator superfamily
S102022_RS15020	COG2267	carboxylic ester hydrolase activity
S102022_RS15025	COG2188	Transcriptional regulator
S102022_RS15030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S102022_RS15035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S102022_RS15040	COG2971	BadF BadG BcrA BcrD
S102022_RS15050	COG2723	6-phospho-beta-galactosidase activity
S102022_RS15070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S102022_RS15075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS15075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS15080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS15080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS15080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S102022_RS15085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS15085	COG1263	PTS System
S102022_RS15085	COG2190	(PTS) system
S102022_RS15090	COG1737	Transcriptional regulator
S102022_RS15095	COG1263	PTS System
S102022_RS15095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS15100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S102022_RS15110	COG2723	6-phospho-beta-galactosidase activity
S102022_RS15115	COG2723	6-phospho-beta-galactosidase activity
S102022_RS15120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S102022_RS15120	COG1263	PTS System
S102022_RS15120	COG2190	(PTS) system
S102022_RS15140	COG2211	Major facilitator Superfamily
S102022_RS15155	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S102022_RS15170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S102022_RS15190	COG3711	transcriptional antiterminator
S102022_RS15205	COG3775	system Galactitol-specific IIC component
S102022_RS15210	COG3414	Phosphotransferase system galactitol-specific IIB component
S102022_RS15220	COG1349	DNA-binding transcription factor activity
S102022_RS15225	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S102022_RS15235	COG0110	maltose O-acetyltransferase activity
S102022_RS15240	COG2160	L-arabinose isomerase activity
S102022_RS15260	COG1609	Transcriptional regulator
S102022_RS15265	COG1737	Transcriptional regulator
S102022_RS15285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S102022_RS15305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S102022_RS15310	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
S102022_RS15340	COG2261	transglycosylase associated protein
S102022_RS15350	COG1393	Belongs to the ArsC family
S102022_RS15370	COG4512	PFAM Accessory gene regulator B
S102022_RS15385	COG1304	FMN binding
S102022_RS15390	COG0028	Belongs to the TPP enzyme family
S102022_RS15395	COG1959	2 iron, 2 sulfur cluster binding
S102022_RS15400	COG0028	Belongs to the TPP enzyme family
S102022_RS15415	COG0235	Class ii aldolase
S102022_RS15420	COG4806	L-rhamnose isomerase
S102022_RS15425	COG3254	rhamnose metabolic process
S102022_RS15430	COG1070	Carbohydrate kinase
S102022_RS15435	COG2814	Major facilitator Superfamily
S102022_RS15440	COG2207	Transcriptional regulator
S102022_RS15445	COG1349	DNA-binding transcription factor activity
S102022_RS15460	COG3775	system Galactitol-specific IIC component
S102022_RS15475	COG2814	Major facilitator Superfamily
S102022_RS15480	COG0673	inositol 2-dehydrogenase activity
S102022_RS15485	COG0673	inositol 2-dehydrogenase activity
S102022_RS15490	COG1082	Xylose isomerase domain protein TIM barrel
S102022_RS15495	COG0673	inositol 2-dehydrogenase activity
S102022_RS15500	COG2814	Major facilitator Superfamily
S102022_RS15505	COG0673	inositol 2-dehydrogenase activity
S102022_RS15510	COG4702	Belongs to the UPF0303 family
S102022_RS15515	COG0604	alcohol dehydrogenase
S102022_RS15520	COG1957	nucleoside hydrolase
S102022_RS15535	COG3732	PTS system glucitol sorbitol-specific
S102022_RS15540	COG3730	PTS system glucitol sorbitol-specific
S102022_RS15550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S102022_RS15550	COG3711	transcriptional antiterminator
S102022_RS15560	COG1609	Transcriptional regulator
S102022_RS15570	COG0366	Alpha amylase catalytic
S102022_RS15580	COG2723	6-phospho-beta-galactosidase activity
S102022_RS15585	COG1940	carbohydrate kinase activity
S102022_RS15590	COG0383	alpha-mannosidase activity
S102022_RS15600	COG2188	Transcriptional regulator
S102022_RS15610	COG3842	ATPase activity
S102022_RS15620	COG2207	Transcriptional regulator
S102022_RS15620	COG4753	response regulator
S102022_RS15625	COG2972	Histidine kinase
S102022_RS15635	COG0366	Alpha amylase catalytic
S102022_RS15640	COG1653	transport
S102022_RS15645	COG0395	ABC-type sugar transport system, permease component
S102022_RS15660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S102022_RS15660	COG2207	Transcriptional regulator
S102022_RS15665	COG1132	(ABC) transporter
S102022_RS15670	COG1132	(ABC) transporter
S102022_RS15675	COG2188	Transcriptional regulator
S102022_RS15690	COG3732	PTS system glucitol sorbitol-specific
S102022_RS15695	COG3730	PTS system glucitol sorbitol-specific
S102022_RS15715	COG4975	Glucose uptake
S102022_RS15720	COG1869	D-ribose catabolic process
S102022_RS15730	COG1609	Transcriptional regulator
S102022_RS15735	COG1012	belongs to the aldehyde dehydrogenase family
S102022_RS15735	COG1454	alcohol dehydrogenase
S102022_RS15745	COG1695	Transcriptional regulator
S102022_RS15750	COG3479	Phenolic acid decarboxylase
S102022_RS15770	COG1307	EDD domain protein, DegV family
S102022_RS15810	COG0445	tRNA wobble uridine modification
S102022_RS15815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S102022_RS15820	COG1847	R3H domain protein
S102022_RS15825	COG0706	membrane insertase activity
S102022_RS15830	COG0594	ribonuclease P activity
S102022_RS15835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S102022_RS15845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S102022_RS15850	COG3118	belongs to the thioredoxin family
S102022_RS15855	COG0492	ferredoxin-NADP+ reductase activity
S102022_RS15865	COG3118	belongs to the thioredoxin family
S102022_RS15880	COG1846	Transcriptional regulator
S102022_RS15920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S102022_RS15935	COG1192	Involved in chromosome partitioning
S102022_RS16000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S102022_RS16065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S102022_RS16120	COG3328	transposase activity
S102022_RS16135	COG3409	Peptidoglycan-binding domain 1 protein
S102022_RS16145	COG0783	Belongs to the Dps family
S102022_RS16150	COG1131	(ABC) transporter
S102022_RS16160	COG1309	transcriptional regulator
S102022_RS16165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S102022_RS16210	COG3716	PTS system mannose fructose sorbose family IID component