locus-tag	class	description
BIZ33_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIZ33_RS00010	COG0592	DNA-directed DNA polymerase activity
BIZ33_RS00015	COG2501	S4 domain
BIZ33_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIZ33_RS00025	COG0187	DNA topoisomerase II activity
BIZ33_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
BIZ33_RS00040	COG0629	single-stranded DNA binding
BIZ33_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIZ33_RS00055	COG0359	binds to the 23S rRNA
BIZ33_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
BIZ33_RS00065	COG2814	Major facilitator Superfamily
BIZ33_RS00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIZ33_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIZ33_RS00080	COG4166	transmembrane transport
BIZ33_RS00090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIZ33_RS00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ33_RS00100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ33_RS00115	COG0366	Alpha amylase catalytic
BIZ33_RS00115	COG3103	Sh3 type 3 domain protein
BIZ33_RS00125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ33_RS00130	COG1554	hydrolase, family 65, central catalytic
BIZ33_RS00140	COG1278	Cold shock
BIZ33_RS00155	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS00160	COG5002	protein histidine kinase activity
BIZ33_RS00170	COG4853	Protein conserved in bacteria
BIZ33_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BIZ33_RS00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ33_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIZ33_RS00195	COG1012	belongs to the aldehyde dehydrogenase family
BIZ33_RS00200	COG3586	endonuclease activity
BIZ33_RS00205	COG1573	uracil-dna glycosylase
BIZ33_RS00225	COG1053	succinate dehydrogenase
BIZ33_RS00225	COG0431	NADPH-dependent FMN reductase
BIZ33_RS00225	COG3976	FMN-binding domain protein
BIZ33_RS00230	COG0471	metal ion transport
BIZ33_RS00245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIZ33_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS00260	COG0778	Nitroreductase
BIZ33_RS00265	COG2508	Transcriptional regulator
BIZ33_RS00275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ33_RS00280	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BIZ33_RS00290	COG2365	Tyrosine phosphatase family
BIZ33_RS00295	COG2368	4-hydroxyphenylacetate
BIZ33_RS00315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIZ33_RS00340	COG0604	alcohol dehydrogenase
BIZ33_RS00370	COG2267	carboxylic ester hydrolase activity
BIZ33_RS00375	COG3022	response to hydroperoxide
BIZ33_RS00385	COG4166	transmembrane transport
BIZ33_RS00410	COG1122	ATPase activity
BIZ33_RS00415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIZ33_RS00420	COG0310	cobalt ion transport
BIZ33_RS00425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ33_RS00430	COG3875	lactate racemase activity
BIZ33_RS00435	COG1691	(AIR) carboxylase
BIZ33_RS00440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIZ33_RS00445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS00450	COG1606	tRNA processing
BIZ33_RS00460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIZ33_RS00465	COG0351	phosphomethylpyrimidine kinase
BIZ33_RS00470	COG0352	thiamine-phosphate diphosphorylase activity
BIZ33_RS00480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BIZ33_RS00495	COG1113	amino acid transport
BIZ33_RS00510	COG2267	carboxylic ester hydrolase activity
BIZ33_RS00515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIZ33_RS00520	COG1983	PspC domain protein
BIZ33_RS00560	COG2807	transmembrane transport
BIZ33_RS00565	COG0656	L-ascorbic acid biosynthetic process
BIZ33_RS00570	COG0667	Aldo Keto reductase
BIZ33_RS00600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIZ33_RS00605	COG1122	ATPase activity
BIZ33_RS00610	COG4720	Psort location CytoplasmicMembrane, score
BIZ33_RS00620	COG2188	Transcriptional regulator
BIZ33_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS00650	COG1131	(ABC) transporter
BIZ33_RS00665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BIZ33_RS00670	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIZ33_RS00675	COG1309	transcriptional regulator
BIZ33_RS00680	COG2376	Dihydroxyacetone kinase
BIZ33_RS00685	COG2376	Dihydroxyacetone kinase
BIZ33_RS00690	COG1461	Dihydroxyacetone kinase
BIZ33_RS00695	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BIZ33_RS00700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS00705	COG1609	Transcriptional regulator
BIZ33_RS00710	COG1609	Transcriptional regulator
BIZ33_RS00715	COG0366	Alpha amylase catalytic
BIZ33_RS00720	COG2182	Extracellular solute-binding protein
BIZ33_RS00725	COG1175	transmembrane transport
BIZ33_RS00730	COG3833	ABC-type maltose transport systems, permease component
BIZ33_RS00740	COG0366	Alpha amylase catalytic
BIZ33_RS00745	COG3842	ATPase activity
BIZ33_RS00800	COG1757	Na H antiporter
BIZ33_RS00825	COG4166	transmembrane transport
BIZ33_RS00830	COG4166	transmembrane transport
BIZ33_RS00840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIZ33_RS00845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIZ33_RS00850	COG0406	alpha-ribazole phosphatase activity
BIZ33_RS00855	COG0667	Aldo Keto reductase
BIZ33_RS00885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIZ33_RS00890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIZ33_RS00895	COG0488	(ABC) transporter
BIZ33_RS00905	COG4172	Belongs to the ABC transporter superfamily
BIZ33_RS00915	COG0386	Belongs to the glutathione peroxidase family
BIZ33_RS00925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ33_RS00940	COG0363	glucosamine-6-phosphate deaminase activity
BIZ33_RS00950	COG2213	PTS system mannitol-specific
BIZ33_RS00960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ33_RS00965	COG0246	Mannitol dehydrogenase
BIZ33_RS00975	COG3118	belongs to the thioredoxin family
BIZ33_RS01010	COG0431	NADPH-dependent FMN reductase
BIZ33_RS01015	COG1045	serine acetyltransferase
BIZ33_RS01020	COG0626	cystathionine gamma-synthase activity
BIZ33_RS01055	COG2188	Transcriptional regulator
BIZ33_RS01060	COG0366	Alpha amylase catalytic
BIZ33_RS01065	COG2190	(PTS) system
BIZ33_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS01065	COG1263	PTS System
BIZ33_RS01070	COG2190	(PTS) system
BIZ33_RS01070	COG1263	PTS System
BIZ33_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS01080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIZ33_RS01085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ33_RS01090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ33_RS01105	COG0163	prenyltransferase activity
BIZ33_RS01115	COG1959	2 iron, 2 sulfur cluster binding
BIZ33_RS01120	COG1309	transcriptional regulator
BIZ33_RS01125	COG1914	H( )-stimulated, divalent metal cation uptake system
BIZ33_RS01145	COG2814	Major facilitator Superfamily
BIZ33_RS01155	COG5002	protein histidine kinase activity
BIZ33_RS01160	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS01170	COG1737	Transcriptional regulator
BIZ33_RS01175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS01190	COG1316	TRANSCRIPTIONal
BIZ33_RS01195	COG0277	FAD linked oxidase domain protein
BIZ33_RS01205	COG2357	RelA SpoT domain protein
BIZ33_RS01215	COG2409	Drug exporters of the RND superfamily
BIZ33_RS01215	COG1033	growth of symbiont in host cell
BIZ33_RS01215	COG2409	Drug exporters of the RND superfamily
BIZ33_RS01215	COG1033	growth of symbiont in host cell
BIZ33_RS01220	COG2818	Glycosylase
BIZ33_RS01230	COG0577	efflux transmembrane transporter activity
BIZ33_RS01235	COG1136	(ABC) transporter
BIZ33_RS01250	COG0741	lytic transglycosylase activity
BIZ33_RS01255	COG3942	CHAP domain
BIZ33_RS01255	COG1388	LysM domain
BIZ33_RS01285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ33_RS01295	COG1846	Transcriptional regulator
BIZ33_RS01300	COG1252	NADH dehydrogenase
BIZ33_RS01325	COG3842	ATPase activity
BIZ33_RS01355	COG1725	Transcriptional regulator
BIZ33_RS01360	COG1131	(ABC) transporter
BIZ33_RS01370	COG1454	alcohol dehydrogenase
BIZ33_RS01370	COG1012	belongs to the aldehyde dehydrogenase family
BIZ33_RS01405	COG1268	BioY protein
BIZ33_RS01430	COG1682	transport, permease protein
BIZ33_RS01435	COG1134	teichoic acid transport
BIZ33_RS01450	COG2814	Major facilitator Superfamily
BIZ33_RS01455	COG0004	ammonium transporteR
BIZ33_RS01475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BIZ33_RS01485	COG3759	membrane
BIZ33_RS01490	COG1881	PFAM PEBP family protein
BIZ33_RS01520	COG0300	oxidoreductase activity
BIZ33_RS01540	COG1125	glycine betaine transport
BIZ33_RS01550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIZ33_RS01560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS01610	COG0110	maltose O-acetyltransferase activity
BIZ33_RS01620	COG0561	phosphatase activity
BIZ33_RS01630	COG0561	phosphatase activity
BIZ33_RS01635	COG1114	Component of the transport system for branched-chain amino acids
BIZ33_RS01670	COG2274	protein secretion by the type I secretion system
BIZ33_RS01705	COG3973	AAA domain
BIZ33_RS01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIZ33_RS01715	COG0180	Tryptophanyl-tRNA synthetase
BIZ33_RS01720	COG2188	Transcriptional regulator
BIZ33_RS01725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS01740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS01745	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS01750	COG1940	carbohydrate kinase activity
BIZ33_RS01760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ33_RS01775	COG0248	Ppx GppA phosphatase
BIZ33_RS01790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIZ33_RS01795	COG1801	Protein of unknown function DUF72
BIZ33_RS01805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ33_RS01805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ33_RS01810	COG2814	Major facilitator Superfamily
BIZ33_RS01825	COG0084	hydrolase, TatD family'
BIZ33_RS01830	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIZ33_RS01835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIZ33_RS01840	COG4466	Protein conserved in bacteria
BIZ33_RS01845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIZ33_RS01850	COG1073	alpha beta
BIZ33_RS01855	COG1121	(ABC) transporter
BIZ33_RS01860	COG1321	iron dependent repressor
BIZ33_RS01860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIZ33_RS01880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ33_RS01885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIZ33_RS01895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIZ33_RS01915	COG1078	dGTPase activity
BIZ33_RS01920	COG0095	Lipoate-protein ligase
BIZ33_RS01930	COG3343	RNA polymerase activity
BIZ33_RS01935	COG0504	CTP synthase activity
BIZ33_RS01940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIZ33_RS01945	COG0814	amino acid
BIZ33_RS01955	COG1760	l-serine dehydratase
BIZ33_RS01960	COG1760	l-serine dehydratase
BIZ33_RS01975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ33_RS01980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIZ33_RS01985	COG0254	rRNA binding
BIZ33_RS01995	COG3764	Sortase (surface protein transpeptidase)
BIZ33_RS02000	COG1704	LemA family
BIZ33_RS02005	COG0501	Belongs to the peptidase M48B family
BIZ33_RS02015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIZ33_RS02030	COG0736	holo-[acyl-carrier-protein] synthase activity
BIZ33_RS02035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIZ33_RS02040	COG2337	Toxic component of a toxin-antitoxin (TA) module
BIZ33_RS02045	COG3158	transport of potassium into the cell
BIZ33_RS02050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ33_RS02055	COG0505	Belongs to the CarA family
BIZ33_RS02060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIZ33_RS02065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIZ33_RS02070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIZ33_RS02075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ33_RS02080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ33_RS02095	COG2267	carboxylic ester hydrolase activity
BIZ33_RS02110	COG0039	L-malate dehydrogenase activity
BIZ33_RS02115	COG0193	aminoacyl-tRNA hydrolase activity
BIZ33_RS02120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIZ33_RS02125	COG2244	polysaccharide biosynthetic process
BIZ33_RS02130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIZ33_RS02140	COG1098	S1 RNA binding domain
BIZ33_RS02145	COG0037	tRNA processing
BIZ33_RS02160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIZ33_RS02165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ33_RS02170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIZ33_RS02210	COG3104	oligopeptide transport
BIZ33_RS02260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIZ33_RS02270	COG2188	Transcriptional regulator
BIZ33_RS02280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIZ33_RS02285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIZ33_RS02300	COG2183	response to ionizing radiation
BIZ33_RS02305	COG3091	SprT-like family
BIZ33_RS02310	COG0460	homoserine dehydrogenase
BIZ33_RS02315	COG0083	homoserine kinase activity
BIZ33_RS02365	COG1396	sequence-specific DNA binding
BIZ33_RS02500	COG0740	serine-type endopeptidase activity
BIZ33_RS02620	COG3715	PTS system
BIZ33_RS02625	COG3716	PTS system mannose fructose sorbose family IID component
BIZ33_RS02635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIZ33_RS02640	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIZ33_RS02665	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIZ33_RS02665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIZ33_RS02670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ33_RS02670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS02675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS02675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ33_RS02680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ33_RS02690	COG0439	Biotin carboxylase
BIZ33_RS02700	COG0825	malonyl-CoA metabolic process
BIZ33_RS02705	COG1316	TRANSCRIPTIONal
BIZ33_RS02715	COG0697	spore germination
BIZ33_RS02720	COG0588	phosphoglycerate mutase activity
BIZ33_RS02735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BIZ33_RS02745	COG0756	dUTP diphosphatase activity
BIZ33_RS02770	COG4956	integral membrane protein (PIN domain superfamily)
BIZ33_RS02775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIZ33_RS02780	COG0215	cysteine-tRNA ligase activity
BIZ33_RS02785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BIZ33_RS02790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ33_RS02805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ33_RS02815	COG0250	Participates in transcription elongation, termination and antitermination
BIZ33_RS02825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIZ33_RS02830	COG0081	regulation of translation
BIZ33_RS02835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIZ33_RS02840	COG0222	ribosome binding
BIZ33_RS02870	COG1611	Belongs to the LOG family
BIZ33_RS02880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ33_RS02885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BIZ33_RS02890	COG2813	Specifically methylates the guanine in position
BIZ33_RS02905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIZ33_RS02910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIZ33_RS02915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIZ33_RS02925	COG3711	transcriptional antiterminator
BIZ33_RS02950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIZ33_RS02955	COG3870	Protein conserved in bacteria
BIZ33_RS02960	COG0470	DNA polymerase III
BIZ33_RS02965	COG4467	Involved in initiation control of chromosome replication
BIZ33_RS02980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIZ33_RS02985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BIZ33_RS02990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ33_RS02995	COG3639	organic phosphonate transmembrane transporter activity
BIZ33_RS03005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BIZ33_RS03015	COG1214	PFAM Peptidase M22, glycoprotease
BIZ33_RS03020	COG0456	acetyltransferase
BIZ33_RS03025	COG0456	acetyltransferase
BIZ33_RS03030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIZ33_RS03040	COG0488	(ABC) transporter
BIZ33_RS03045	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIZ33_RS03055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIZ33_RS03060	COG0459	protein refolding
BIZ33_RS03065	COG0531	amino acid
BIZ33_RS03070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ33_RS03075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIZ33_RS03080	COG1739	Uncharacterized protein family UPF0029
BIZ33_RS03100	COG0653	protein targeting
BIZ33_RS03105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIZ33_RS03115	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS03120	COG5002	protein histidine kinase activity
BIZ33_RS03125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIZ33_RS03130	COG0573	inorganic phosphate transmembrane transporter activity
BIZ33_RS03135	COG0581	inorganic phosphate transmembrane transporter activity
BIZ33_RS03140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIZ33_RS03145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIZ33_RS03150	COG0704	Plays a role in the regulation of phosphate uptake
BIZ33_RS03155	COG1983	PspC domain protein
BIZ33_RS03160	COG1950	PFAM Membrane protein of
BIZ33_RS03165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIZ33_RS03170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIZ33_RS03175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BIZ33_RS03180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ33_RS03190	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS03195	COG0492	ferredoxin-NADP+ reductase activity
BIZ33_RS03220	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS03230	COG2814	Major facilitator Superfamily
BIZ33_RS03240	COG0556	nucleotide-excision repair
BIZ33_RS03245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ33_RS03250	COG1854	S-ribosylhomocysteine lyase activity
BIZ33_RS03255	COG0137	argininosuccinate synthase activity
BIZ33_RS03260	COG0165	Argininosuccinate lyase
BIZ33_RS03270	COG1660	Displays ATPase and GTPase activities
BIZ33_RS03280	COG1481	regulation of sporulation
BIZ33_RS03290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ33_RS03295	COG0740	serine-type endopeptidase activity
BIZ33_RS03305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIZ33_RS03310	COG2390	Transcriptional regulator
BIZ33_RS03320	COG0126	phosphoglycerate kinase activity
BIZ33_RS03325	COG0149	triose-phosphate isomerase activity
BIZ33_RS03330	COG0148	phosphopyruvate hydratase activity
BIZ33_RS03345	COG0038	chloride channel
BIZ33_RS03350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ33_RS03360	COG0557	exoribonuclease II activity
BIZ33_RS03365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BIZ33_RS03375	COG0765	amino acid transport
BIZ33_RS03380	COG1126	abc transporter atp-binding protein
BIZ33_RS03390	COG0561	phosphatase activity
BIZ33_RS03395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIZ33_RS03400	COG0280	phosphate acetyltransferase
BIZ33_RS03405	COG0802	atpase or kinase
BIZ33_RS03420	COG0708	Exodeoxyribonuclease III
BIZ33_RS03430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIZ33_RS03435	COG0025	NhaP-type Na H and K H
BIZ33_RS03460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ33_RS03465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ33_RS03475	COG0561	phosphatase activity
BIZ33_RS03485	COG2017	converts alpha-aldose to the beta-anomer
BIZ33_RS03500	COG0778	Nitroreductase
BIZ33_RS03525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIZ33_RS03540	COG1393	Belongs to the ArsC family
BIZ33_RS03555	COG0477	Major facilitator Superfamily
BIZ33_RS03565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BIZ33_RS03575	COG3475	LICD family
BIZ33_RS03590	COG2252	PERMEase
BIZ33_RS03595	COG0028	Belongs to the TPP enzyme family
BIZ33_RS03600	COG0196	riboflavin kinase activity
BIZ33_RS03605	COG0028	Belongs to the TPP enzyme family
BIZ33_RS03615	COG2267	carboxylic ester hydrolase activity
BIZ33_RS03625	COG2755	lipolytic protein G-D-S-L family
BIZ33_RS03625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIZ33_RS03630	COG2936	dipeptidyl-peptidase activity
BIZ33_RS03645	COG0531	amino acid
BIZ33_RS03670	COG0194	GDP metabolic process
BIZ33_RS03675	COG0735	belongs to the Fur family
BIZ33_RS03690	COG0546	phosphoglycolate phosphatase activity
BIZ33_RS03695	COG0436	Aminotransferase
BIZ33_RS03700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ33_RS03720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ33_RS03725	COG0765	amino acid transport
BIZ33_RS03730	COG0765	amino acid transport
BIZ33_RS03735	COG2190	(PTS) system
BIZ33_RS03735	COG1263	PTS System
BIZ33_RS03735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS03745	COG1263	PTS System
BIZ33_RS03750	COG3394	polysaccharide catabolic process
BIZ33_RS03755	COG0531	amino acid
BIZ33_RS03765	COG1846	Transcriptional regulator
BIZ33_RS03795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIZ33_RS03805	COG2076	Multidrug Resistance protein
BIZ33_RS03820	COG0588	phosphoglycerate mutase activity
BIZ33_RS03825	COG0475	glutathione-regulated potassium exporter activity
BIZ33_RS03825	COG0569	domain protein
BIZ33_RS03830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BIZ33_RS03830	COG0456	acetyltransferase
BIZ33_RS03835	COG3711	transcriptional antiterminator
BIZ33_RS03840	COG1263	PTS System
BIZ33_RS03840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS03840	COG2190	(PTS) system
BIZ33_RS03845	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS03850	COG0586	Pfam SNARE associated Golgi protein
BIZ33_RS03855	COG3973	AAA domain
BIZ33_RS03860	COG2070	2-Nitropropane dioxygenase
BIZ33_RS03865	COG1072	(Pantothenic acid kinase))
BIZ33_RS03870	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ33_RS03870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BIZ33_RS03880	COG1396	sequence-specific DNA binding
BIZ33_RS03890	COG1266	CAAX protease self-immunity
BIZ33_RS03895	COG1733	regulation of RNA biosynthetic process
BIZ33_RS03900	COG2814	Major facilitator Superfamily
BIZ33_RS03940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIZ33_RS03940	COG2755	lipolytic protein G-D-S-L family
BIZ33_RS03945	COG2261	transglycosylase associated protein
BIZ33_RS03960	COG1302	Protein conserved in bacteria
BIZ33_RS03990	COG0308	aminopeptidase N
BIZ33_RS04010	COG2801	Transposase and inactivated derivatives
BIZ33_RS04040	COG0572	uridine kinase
BIZ33_RS04055	COG0583	DNA-binding transcription factor activity
BIZ33_RS04060	COG1053	succinate dehydrogenase
BIZ33_RS04070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIZ33_RS04075	COG0017	Asparaginyl-tRNA synthetase
BIZ33_RS04080	COG2502	aspartate--ammonia ligase
BIZ33_RS04085	COG4690	dipeptidase activity
BIZ33_RS04105	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ33_RS04110	COG0564	pseudouridine synthase activity
BIZ33_RS04115	COG0640	Transcriptional regulator
BIZ33_RS04150	COG2706	6-phosphogluconolactonase activity
BIZ33_RS04155	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ33_RS04160	COG2610	gluconate transmembrane transporter activity
BIZ33_RS04170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIZ33_RS04175	COG0583	DNA-binding transcription factor activity
BIZ33_RS04200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIZ33_RS04205	COG0527	aspartate kinase activity
BIZ33_RS04210	COG0367	asparagine synthase
BIZ33_RS04260	COG2814	Major facilitator Superfamily
BIZ33_RS04280	COG1278	Cold shock
BIZ33_RS04285	COG2966	Psort location CytoplasmicMembrane, score
BIZ33_RS04295	COG1316	TRANSCRIPTIONal
BIZ33_RS04315	COG1959	2 iron, 2 sulfur cluster binding
BIZ33_RS04325	COG0028	Belongs to the TPP enzyme family
BIZ33_RS04330	COG0833	amino acid
BIZ33_RS04340	COG1428	Deoxynucleoside kinase
BIZ33_RS04345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIZ33_RS04385	COG4463	regulation of RNA biosynthetic process
BIZ33_RS04400	COG0085	RNA polymerase activity
BIZ33_RS04405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIZ33_RS04410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIZ33_RS04415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIZ33_RS04420	COG0049	tRNA binding
BIZ33_RS04425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIZ33_RS04430	COG0051	transcription antitermination factor activity, RNA binding
BIZ33_RS04435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIZ33_RS04440	COG0088	Forms part of the polypeptide exit tunnel
BIZ33_RS04445	COG0089	rRNA binding
BIZ33_RS04450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIZ33_RS04455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIZ33_RS04460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BIZ33_RS04465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIZ33_RS04470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIZ33_RS04475	COG0255	Belongs to the universal ribosomal protein uL29 family
BIZ33_RS04480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIZ33_RS04485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIZ33_RS04490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIZ33_RS04495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIZ33_RS04500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ33_RS04505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIZ33_RS04510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIZ33_RS04515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIZ33_RS04520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BIZ33_RS04525	COG1841	ribosomal large subunit assembly
BIZ33_RS04530	COG0200	Binds to the 23S rRNA
BIZ33_RS04540	COG0563	adenylate kinase activity
BIZ33_RS04545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIZ33_RS04550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIZ33_RS04555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BIZ33_RS04560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIZ33_RS04565	COG0202	RNA polymerase activity
BIZ33_RS04570	COG0203	ribosomal protein L17
BIZ33_RS04610	COG4939	FMN-binding domain protein
BIZ33_RS04620	COG1122	ATPase activity
BIZ33_RS04625	COG1122	ATPase activity
BIZ33_RS04635	COG0101	tRNA pseudouridine synthase activity
BIZ33_RS04640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIZ33_RS04645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BIZ33_RS04670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIZ33_RS04675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BIZ33_RS04680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIZ33_RS04685	COG0471	metal ion transport
BIZ33_RS04690	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ33_RS04695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BIZ33_RS04705	COG1917	Cupin 2, conserved barrel domain protein
BIZ33_RS04705	COG4977	sequence-specific DNA binding
BIZ33_RS04710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BIZ33_RS04715	COG1121	(ABC) transporter
BIZ33_RS04720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIZ33_RS04725	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIZ33_RS04735	COG0039	L-malate dehydrogenase activity
BIZ33_RS04740	COG0471	metal ion transport
BIZ33_RS04760	COG3052	prosthetic group binding
BIZ33_RS04775	COG2826	transposase and inactivated derivatives, IS30 family
BIZ33_RS04810	COG0114	fumarate hydratase activity
BIZ33_RS04815	COG1053	succinate dehydrogenase
BIZ33_RS04825	COG0583	DNA-binding transcription factor activity
BIZ33_RS04830	COG0583	DNA-binding transcription factor activity
BIZ33_RS04835	COG0281	malic enzyme
BIZ33_RS04845	COG0531	amino acid
BIZ33_RS04850	COG4684	Psort location CytoplasmicMembrane, score
BIZ33_RS04865	COG1271	oxidase subunit
BIZ33_RS04870	COG1294	oxidase, subunit
BIZ33_RS04875	COG4988	ABC transporter
BIZ33_RS04880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIZ33_RS04895	COG0142	geranyltranstransferase activity
BIZ33_RS04910	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIZ33_RS04915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ33_RS04920	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BIZ33_RS04925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIZ33_RS04935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIZ33_RS04940	COG4851	CamS sex pheromone cAM373 precursor
BIZ33_RS04945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ33_RS04950	COG0154	amidase activity
BIZ33_RS04955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ33_RS04960	COG1597	lipid kinase activity
BIZ33_RS04965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIZ33_RS04980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS04990	COG1737	Transcriptional regulator
BIZ33_RS05005	COG1278	Cold shock
BIZ33_RS05010	COG0673	inositol 2-dehydrogenase activity
BIZ33_RS05015	COG0513	Belongs to the DEAD box helicase family
BIZ33_RS05030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS05055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIZ33_RS05065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BIZ33_RS05075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS05095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIZ33_RS05130	COG2137	regulation of response to DNA damage stimulus
BIZ33_RS05135	COG3557	Belongs to the UPF0374 family
BIZ33_RS05155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ33_RS05165	COG0628	permease
BIZ33_RS05170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIZ33_RS05175	COG2610	gluconate transmembrane transporter activity
BIZ33_RS05180	COG1070	Carbohydrate kinase
BIZ33_RS05185	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ33_RS05190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ33_RS05195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIZ33_RS05225	COG4166	transmembrane transport
BIZ33_RS05230	COG0601	transmembrane transport
BIZ33_RS05235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIZ33_RS05240	COG0444	Belongs to the ABC transporter superfamily
BIZ33_RS05245	COG4608	Belongs to the ABC transporter superfamily
BIZ33_RS05255	COG0582	viral genome integration into host DNA
BIZ33_RS05260	COG0542	response to heat
BIZ33_RS05280	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS05285	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS05295	COG1686	Belongs to the peptidase S11 family
BIZ33_RS05300	COG0436	Aminotransferase
BIZ33_RS05305	COG4703	Protein of unknown function (DUF1797)
BIZ33_RS05310	COG1368	sulfuric ester hydrolase activity
BIZ33_RS05400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ33_RS05420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIZ33_RS05435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BIZ33_RS05445	COG2040	homocysteine
BIZ33_RS05450	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS05460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIZ33_RS05465	COG0477	Major facilitator Superfamily
BIZ33_RS05480	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS05495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BIZ33_RS05505	COG0495	leucyl-tRNA aminoacylation
BIZ33_RS05510	COG2244	polysaccharide biosynthetic process
BIZ33_RS05515	COG1187	pseudouridine synthase activity
BIZ33_RS05520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIZ33_RS05525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ33_RS05535	COG3842	ATPase activity
BIZ33_RS05540	COG1175	transmembrane transport
BIZ33_RS05545	COG0395	ABC-type sugar transport system, permease component
BIZ33_RS05555	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ33_RS05560	COG1428	Deoxynucleoside kinase
BIZ33_RS05565	COG1970	mechanosensitive ion channel activity
BIZ33_RS05600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ33_RS05605	COG0789	Transcriptional regulator
BIZ33_RS05615	COG0697	spore germination
BIZ33_RS05620	COG0561	phosphatase activity
BIZ33_RS05640	COG3279	Response regulator of the LytR AlgR family
BIZ33_RS05660	COG1846	Transcriptional regulator
BIZ33_RS05675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ33_RS05715	COG0646	methionine synthase
BIZ33_RS05715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIZ33_RS05720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ33_RS05730	COG2046	Belongs to the sulfate adenylyltransferase family
BIZ33_RS05735	COG0529	Catalyzes the synthesis of activated sulfate
BIZ33_RS05740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIZ33_RS05750	COG0471	metal ion transport
BIZ33_RS05750	COG3273	potassium ion transport
BIZ33_RS05755	COG0534	Mate efflux family protein
BIZ33_RS05775	COG2153	protein acetylation
BIZ33_RS05780	COG0018	arginyl-trna synthetase
BIZ33_RS05790	COG1136	(ABC) transporter
BIZ33_RS05790	COG0577	efflux transmembrane transporter activity
BIZ33_RS05810	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ33_RS05815	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS05820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS05825	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS05835	COG1376	ErfK ybiS ycfS ynhG family protein
BIZ33_RS05840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ33_RS05845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ33_RS05855	COG0436	Aminotransferase
BIZ33_RS05860	COG1438	arginine binding
BIZ33_RS05870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ33_RS05875	COG3679	Belongs to the UPF0342 family
BIZ33_RS05880	COG0420	3'-5' exonuclease activity
BIZ33_RS05885	COG4717	serine-type aminopeptidase activity
BIZ33_RS05890	COG3481	metal-dependent phosphohydrolase, HD sub domain
BIZ33_RS05910	COG0583	DNA-binding transcription factor activity
BIZ33_RS05925	COG0431	NADPH-dependent FMN reductase
BIZ33_RS05925	COG1053	succinate dehydrogenase
BIZ33_RS05925	COG3976	FMN-binding domain protein
BIZ33_RS05945	COG0463	Glycosyl transferase, family 2
BIZ33_RS05965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ33_RS05965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ33_RS05970	COG0307	riboflavin synthase, alpha
BIZ33_RS05975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ33_RS05975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ33_RS05980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIZ33_RS05995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ33_RS06005	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS06040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIZ33_RS06050	COG0537	adenosine 5'-monophosphoramidase activity
BIZ33_RS06055	COG1131	(ABC) transporter
BIZ33_RS06060	COG4473	ABC transporter
BIZ33_RS06065	COG0510	thiamine kinase activity
BIZ33_RS06070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIZ33_RS06080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ33_RS06085	COG1674	ftsk spoiiie
BIZ33_RS06090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIZ33_RS06115	COG0719	Fe-S assembly protein
BIZ33_RS06120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIZ33_RS06130	COG0719	Fe-S assembly protein
BIZ33_RS06135	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ33_RS06150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ33_RS06150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ33_RS06155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ33_RS06160	COG0237	dephospho-CoA kinase activity
BIZ33_RS06165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIZ33_RS06170	COG3611	Membrane attachment protein
BIZ33_RS06175	COG1484	DNA-dependent DNA replication
BIZ33_RS06180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIZ33_RS06185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIZ33_RS06190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BIZ33_RS06195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIZ33_RS06205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ33_RS06210	COG0604	alcohol dehydrogenase
BIZ33_RS06215	COG1733	regulation of RNA biosynthetic process
BIZ33_RS06225	COG1215	transferase activity, transferring glycosyl groups
BIZ33_RS06240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ33_RS06245	COG1534	Rna-binding protein
BIZ33_RS06250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIZ33_RS06255	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIZ33_RS06260	COG0799	negative regulation of ribosome biogenesis
BIZ33_RS06265	COG2226	methyltransferase
BIZ33_RS06270	COG1323	Belongs to the UPF0348 family
BIZ33_RS06280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BIZ33_RS06295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIZ33_RS06305	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS06310	COG5002	protein histidine kinase activity
BIZ33_RS06325	COG0419	ATPase involved in DNA repair
BIZ33_RS06340	COG0706	membrane insertase activity
BIZ33_RS06345	COG1254	Belongs to the acylphosphatase family
BIZ33_RS06350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ33_RS06360	COG1733	regulation of RNA biosynthetic process
BIZ33_RS06365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIZ33_RS06370	COG0072	phenylalanine-tRNA ligase activity
BIZ33_RS06370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ33_RS06375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIZ33_RS06380	COG0572	uridine kinase
BIZ33_RS06385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ33_RS06400	COG4841	protein insertion into membrane
BIZ33_RS06410	COG0768	penicillin binding
BIZ33_RS06415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ33_RS06420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIZ33_RS06425	COG0457	Tetratricopeptide repeat
BIZ33_RS06425	COG0705	Rhomboid family
BIZ33_RS06435	COG1940	carbohydrate kinase activity
BIZ33_RS06455	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ33_RS06460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIZ33_RS06465	COG0789	Transcriptional regulator
BIZ33_RS06515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BIZ33_RS06525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIZ33_RS06530	COG0006	proline dipeptidase activity
BIZ33_RS06535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIZ33_RS06540	COG1302	Protein conserved in bacteria
BIZ33_RS06545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ33_RS06550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BIZ33_RS06555	COG1570	exodeoxyribonuclease VII activity
BIZ33_RS06560	COG1722	exodeoxyribonuclease VII activity
BIZ33_RS06565	COG0142	geranyltranstransferase activity
BIZ33_RS06570	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BIZ33_RS06575	COG1438	arginine binding
BIZ33_RS06580	COG0497	DNA recombination
BIZ33_RS06595	COG1732	Glycine betaine
BIZ33_RS06610	COG0194	GDP metabolic process
BIZ33_RS06615	COG1758	RNA polymerase activity
BIZ33_RS06620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIZ33_RS06625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIZ33_RS06630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIZ33_RS06635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ33_RS06635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ33_RS06640	COG0631	protein serine/threonine phosphatase activity
BIZ33_RS06645	COG0515	serine threonine protein kinase
BIZ33_RS06645	COG2815	serine threonine protein kinase
BIZ33_RS06650	COG1162	GTPase activity
BIZ33_RS06655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ33_RS06660	COG1564	THIamine pyrophosphokinase
BIZ33_RS06665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIZ33_RS06670	COG1302	Protein conserved in bacteria
BIZ33_RS06675	COG1461	Dihydroxyacetone kinase
BIZ33_RS06680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIZ33_RS06685	COG0416	fatty acid biosynthetic process
BIZ33_RS06690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ33_RS06695	COG0571	ribonuclease III activity
BIZ33_RS06700	COG1196	nuclear chromosome segregation
BIZ33_RS06705	COG0552	protein localization to endoplasmic reticulum
BIZ33_RS06710	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIZ33_RS06715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIZ33_RS06720	COG0228	four-way junction DNA binding
BIZ33_RS06725	COG1837	Belongs to the UPF0109 family
BIZ33_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIZ33_RS06735	COG0336	Belongs to the RNA methyltransferase TrmD family
BIZ33_RS06740	COG0335	large ribosomal subunit rRNA binding
BIZ33_RS06760	COG1131	(ABC) transporter
BIZ33_RS06775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ33_RS06775	COG0512	Glutamine amidotransferase of anthranilate synthase
BIZ33_RS06780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ33_RS06785	COG0134	indole-3-glycerol-phosphate synthase activity
BIZ33_RS06790	COG0135	phosphoribosylanthranilate isomerase activity
BIZ33_RS06795	COG0133	tryptophan synthase activity
BIZ33_RS06800	COG0159	tryptophan synthase activity
BIZ33_RS06820	COG1063	alcohol dehydrogenase
BIZ33_RS06830	COG0300	oxidoreductase activity
BIZ33_RS06840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIZ33_RS06845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ33_RS06850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ33_RS06855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIZ33_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS06865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ33_RS06880	COG0439	Biotin carboxylase
BIZ33_RS06895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIZ33_RS06905	COG1811	Na channel or pump
BIZ33_RS06910	COG0583	DNA-binding transcription factor activity
BIZ33_RS06915	COG1607	acyl-coa hydrolase
BIZ33_RS06920	COG1162	GTPase activity
BIZ33_RS06930	COG0477	Major facilitator Superfamily
BIZ33_RS06970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BIZ33_RS06975	COG3397	chitin binding
BIZ33_RS06980	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BIZ33_RS06990	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BIZ33_RS07000	COG3152	Membrane
BIZ33_RS07020	COG2261	transglycosylase associated protein
BIZ33_RS07025	COG3237	CsbD-like
BIZ33_RS07040	COG1942	4-Oxalocrotonate Tautomerase
BIZ33_RS07080	COG0531	amino acid
BIZ33_RS07085	COG0561	phosphatase activity
BIZ33_RS07090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ33_RS07090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BIZ33_RS07110	COG2017	converts alpha-aldose to the beta-anomer
BIZ33_RS07115	COG1304	FMN binding
BIZ33_RS07140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIZ33_RS07140	COG1199	ATP-dependent helicase activity
BIZ33_RS07155	COG0017	Asparaginyl-tRNA synthetase
BIZ33_RS07170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIZ33_RS07175	COG2011	ABC-type metal ion transport system permease component
BIZ33_RS07180	COG1464	Belongs to the NlpA lipoprotein family
BIZ33_RS07190	COG1177	transmembrane transport
BIZ33_RS07195	COG1840	ABC-type Fe3 transport system, periplasmic component
BIZ33_RS07210	COG3331	DNA recombination
BIZ33_RS07215	COG4474	Belongs to the UPF0398 family
BIZ33_RS07220	COG3599	regulation of cell shape
BIZ33_RS07230	COG0116	Belongs to the methyltransferase superfamily
BIZ33_RS07235	COG1073	alpha beta
BIZ33_RS07245	COG1216	Glycosyl transferase, family 2
BIZ33_RS07265	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIZ33_RS07290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ33_RS07305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BIZ33_RS07310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIZ33_RS07315	COG0564	pseudouridine synthase activity
BIZ33_RS07320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIZ33_RS07325	COG0505	Belongs to the CarA family
BIZ33_RS07330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ33_RS07340	COG5646	InterPro IPR014922
BIZ33_RS07365	COG1131	(ABC) transporter
BIZ33_RS07370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIZ33_RS07375	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BIZ33_RS07385	COG1307	EDD domain protein, DegV family
BIZ33_RS07445	COG1113	amino acid transport
BIZ33_RS07460	COG1620	l-lactate permease
BIZ33_RS07470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BIZ33_RS07480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ33_RS07495	COG1846	Transcriptional regulator
BIZ33_RS07535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ33_RS07540	COG1227	inorganic diphosphatase activity
BIZ33_RS07545	COG0583	DNA-binding transcription factor activity
BIZ33_RS07555	COG0187	DNA topoisomerase II activity
BIZ33_RS07560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIZ33_RS07570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BIZ33_RS07575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIZ33_RS07580	COG4974	Belongs to the 'phage' integrase family
BIZ33_RS07585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BIZ33_RS07590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ33_RS07595	COG0758	DNA mediated transformation
BIZ33_RS07600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIZ33_RS07605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ33_RS07615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ33_RS07620	COG0583	DNA-binding transcription factor activity
BIZ33_RS07650	COG2814	Major facilitator Superfamily
BIZ33_RS07655	COG3409	Peptidoglycan-binding domain 1 protein
BIZ33_RS07655	COG0793	Belongs to the peptidase S41A family
BIZ33_RS07660	COG4479	Belongs to the UPF0346 family
BIZ33_RS07665	COG4698	Protein conserved in bacteria
BIZ33_RS07670	COG2755	lipolytic protein G-D-S-L family
BIZ33_RS07675	COG1307	EDD domain protein, DegV family
BIZ33_RS07680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIZ33_RS07685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIZ33_RS07690	COG0488	(ABC) transporter
BIZ33_RS07700	COG0617	tRNA 3'-terminal CCA addition
BIZ33_RS07705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIZ33_RS07710	COG0561	phosphatase activity
BIZ33_RS07715	COG0457	Tetratricopeptide repeat
BIZ33_RS07730	COG1160	GTP binding
BIZ33_RS07735	COG0539	negative regulation of cytoplasmic translation
BIZ33_RS07740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIZ33_RS07750	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ33_RS07760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIZ33_RS07765	COG1187	pseudouridine synthase activity
BIZ33_RS07770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIZ33_RS07775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIZ33_RS07785	COG4974	Belongs to the 'phage' integrase family
BIZ33_RS07790	COG2996	Protein conserved in bacteria
BIZ33_RS07810	COG0205	6-phosphofructokinase activity
BIZ33_RS07815	COG0587	DNA-directed DNA polymerase activity
BIZ33_RS07825	COG0542	response to heat
BIZ33_RS07835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIZ33_RS07840	COG2384	SAM-dependent methyltransferase
BIZ33_RS07865	COG0574	Belongs to the PEP-utilizing enzyme family
BIZ33_RS07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIZ33_RS07875	COG1846	Transcriptional regulator
BIZ33_RS07900	COG0148	phosphopyruvate hydratase activity
BIZ33_RS07905	COG0477	Major facilitator Superfamily
BIZ33_RS07915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ33_RS07920	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS07925	COG1349	DNA-binding transcription factor activity
BIZ33_RS07930	COG1051	belongs to the nudix hydrolase family
BIZ33_RS07935	COG1393	Belongs to the ArsC family
BIZ33_RS07955	COG0546	phosphoglycolate phosphatase activity
BIZ33_RS07985	COG0583	DNA-binding transcription factor activity
BIZ33_RS07990	COG0604	alcohol dehydrogenase
BIZ33_RS08000	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS08005	COG2197	response regulator
BIZ33_RS08010	COG4585	Histidine kinase
BIZ33_RS08020	COG1131	(ABC) transporter
BIZ33_RS08030	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ33_RS08045	COG1131	(ABC) transporter
BIZ33_RS08065	COG1131	(ABC) transporter
BIZ33_RS08070	COG1725	Transcriptional regulator
BIZ33_RS08080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIZ33_RS08085	COG0358	DNA primase activity
BIZ33_RS08090	COG0751	glycine-tRNA ligase activity
BIZ33_RS08095	COG0752	glycyl-tRNA synthetase alpha subunit
BIZ33_RS08100	COG1381	Involved in DNA repair and RecF pathway recombination
BIZ33_RS08105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIZ33_RS08110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIZ33_RS08115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIZ33_RS08120	COG1702	phosphate starvation-inducible protein PhoH
BIZ33_RS08125	COG1610	YqeY-like protein
BIZ33_RS08130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BIZ33_RS08135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIZ33_RS08145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIZ33_RS08155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ33_RS08165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIZ33_RS08170	COG0124	histidyl-tRNA synthetase
BIZ33_RS08175	COG4991	sh3 domain protein
BIZ33_RS08175	COG3103	Sh3 type 3 domain protein
BIZ33_RS08175	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ33_RS08180	COG3001	Fructosamine kinase
BIZ33_RS08185	COG0546	phosphoglycolate phosphatase activity
BIZ33_RS08190	COG1490	D-aminoacyl-tRNA deacylase activity
BIZ33_RS08195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ33_RS08205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIZ33_RS08210	COG2264	protein methyltransferase activity
BIZ33_RS08215	COG2094	Belongs to the DNA glycosylase MPG family
BIZ33_RS08230	COG0481	GTPase activity
BIZ33_RS08235	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BIZ33_RS08240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ33_RS08245	COG1696	Membrane protein involved in D-alanine export
BIZ33_RS08250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIZ33_RS08260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ33_RS08265	COG0484	heat shock protein binding
BIZ33_RS08270	COG0443	Heat shock 70 kDa protein
BIZ33_RS08275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIZ33_RS08280	COG1420	regulation of RNA biosynthetic process
BIZ33_RS08285	COG3527	Alpha-acetolactate decarboxylase
BIZ33_RS08290	COG0196	riboflavin kinase activity
BIZ33_RS08295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIZ33_RS08300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIZ33_RS08305	COG0287	Prephenate dehydrogenase
BIZ33_RS08310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIZ33_RS08320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIZ33_RS08325	COG0738	Major facilitator superfamily
BIZ33_RS08330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIZ33_RS08335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIZ33_RS08345	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BIZ33_RS08350	COG0195	Participates in both transcription termination and antitermination
BIZ33_RS08355	COG0779	Required for maturation of 30S ribosomal subunits
BIZ33_RS08360	COG2176	DNA-directed DNA polymerase activity
BIZ33_RS08365	COG0442	prolyl-tRNA aminoacylation
BIZ33_RS08370	COG0750	zinc metalloprotease
BIZ33_RS08375	COG4589	Belongs to the CDS family
BIZ33_RS08380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIZ33_RS08385	COG0233	cytoplasmic translational termination
BIZ33_RS08390	COG0528	UMP kinase activity
BIZ33_RS08395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIZ33_RS08400	COG0052	Belongs to the universal ribosomal protein uS2 family
BIZ33_RS08410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ33_RS08415	COG2827	Endonuclease containing a URI domain
BIZ33_RS08420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BIZ33_RS08425	COG0204	Acyl-transferase
BIZ33_RS08430	COG3763	UPF0154 protein
BIZ33_RS08435	COG4224	UPF0291 protein
BIZ33_RS08440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIZ33_RS08450	COG3425	synthase
BIZ33_RS08465	COG0463	Glycosyl transferase, family 2
BIZ33_RS08480	COG1316	TRANSCRIPTIONal
BIZ33_RS08485	COG1116	anion transmembrane transporter activity
BIZ33_RS08495	COG0772	Belongs to the SEDS family
BIZ33_RS08545	COG3953	SLT domain
BIZ33_RS08545	COG5280	Phage tail tape measure protein TP901
BIZ33_RS08785	COG0393	Putative heavy-metal-binding
BIZ33_RS08800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ33_RS08805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BIZ33_RS08805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIZ33_RS08810	COG5416	Lipopolysaccharide assembly protein A domain
BIZ33_RS08815	COG0300	oxidoreductase activity
BIZ33_RS08820	COG1234	tRNA 3'-trailer cleavage
BIZ33_RS08830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIZ33_RS08835	COG1349	DNA-binding transcription factor activity
BIZ33_RS08840	COG1105	Belongs to the carbohydrate kinase PfkB family
BIZ33_RS08845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ33_RS08845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ33_RS08845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ33_RS08875	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS08880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIZ33_RS08885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIZ33_RS08895	COG0489	protein tyrosine kinase activity
BIZ33_RS08905	COG0322	excinuclease ABC activity
BIZ33_RS08910	COG1126	abc transporter atp-binding protein
BIZ33_RS08915	COG0765	amino acid transport
BIZ33_RS08935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIZ33_RS08940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BIZ33_RS08945	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIZ33_RS08950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIZ33_RS08975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIZ33_RS08980	COG0268	Binds directly to 16S ribosomal RNA
BIZ33_RS08985	COG1466	dna polymerase III delta subunit
BIZ33_RS08990	COG0658	competence protein
BIZ33_RS08990	COG2333	competence protein COMEC
BIZ33_RS08995	COG2131	deaminase
BIZ33_RS09000	COG1555	photosystem II stabilization
BIZ33_RS09000	COG1596	polysaccharide export
BIZ33_RS09005	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIZ33_RS09010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIZ33_RS09015	COG0742	ribosomal rna small subunit methyltransferase
BIZ33_RS09020	COG4471	UPF0298 protein
BIZ33_RS09025	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BIZ33_RS09030	COG0772	Belongs to the SEDS family
BIZ33_RS09065	COG1217	gtp-binding protein TYPA
BIZ33_RS09070	COG0483	inositol monophosphate 1-phosphatase activity
BIZ33_RS09075	COG4476	Belongs to the UPF0223 family
BIZ33_RS09080	COG0039	L-malate dehydrogenase activity
BIZ33_RS09105	COG0242	peptide deformylase activity
BIZ33_RS09115	COG5503	Protein of unknown function (DUF1447)
BIZ33_RS09120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIZ33_RS09125	COG1597	lipid kinase activity
BIZ33_RS09135	COG3584	3D domain protein
BIZ33_RS09135	COG1388	LysM domain
BIZ33_RS09140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIZ33_RS09145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIZ33_RS09180	COG0569	domain protein
BIZ33_RS09185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIZ33_RS09190	COG0482	sulfurtransferase activity
BIZ33_RS09200	COG1104	cysteine desulfurase activity
BIZ33_RS09205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIZ33_RS09215	COG0494	nUDIX hydrolase
BIZ33_RS09220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIZ33_RS09225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIZ33_RS09230	COG3599	regulation of cell shape
BIZ33_RS09240	COG0762	integral membrane protein
BIZ33_RS09245	COG1799	cell septum assembly
BIZ33_RS09260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIZ33_RS09265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ33_RS09270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIZ33_RS09275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ33_RS09280	COG0768	penicillin binding
BIZ33_RS09290	COG0275	rRNA processing
BIZ33_RS09295	COG2001	Belongs to the MraZ family
BIZ33_RS09315	COG1674	ftsk spoiiie
BIZ33_RS09320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIZ33_RS09330	COG1114	Component of the transport system for branched-chain amino acids
BIZ33_RS09345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ33_RS09350	COG0628	permease
BIZ33_RS09360	COG2706	6-phosphogluconolactonase activity
BIZ33_RS09365	COG3142	Participates in the control of copper homeostasis
BIZ33_RS09370	COG0564	pseudouridine synthase activity
BIZ33_RS09375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIZ33_RS09380	COG2357	RelA SpoT domain protein
BIZ33_RS09390	COG1164	Oligoendopeptidase f
BIZ33_RS09400	COG4862	establishment of competence for transformation
BIZ33_RS09405	COG1393	Belongs to the ArsC family
BIZ33_RS09410	COG1234	tRNA 3'-trailer cleavage
BIZ33_RS09550	COG1098	S1 RNA binding domain
BIZ33_RS09560	COG0586	Pfam SNARE associated Golgi protein
BIZ33_RS09570	COG0647	UMP catabolic process
BIZ33_RS09575	COG4470	Protein conserved in bacteria
BIZ33_RS09580	COG0737	Belongs to the 5'-nucleotidase family
BIZ33_RS09595	COG1113	amino acid transport
BIZ33_RS09600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ33_RS09605	COG0827	DNA restriction-modification system
BIZ33_RS09650	COG0217	transcriptional regulatory protein
BIZ33_RS09665	COG1609	Transcriptional regulator
BIZ33_RS09670	COG0006	proline dipeptidase activity
BIZ33_RS09675	COG0789	Transcriptional regulator
BIZ33_RS09690	COG0668	transmembrane transport
BIZ33_RS09695	COG1473	amidohydrolase
BIZ33_RS09700	COG2171	N-acyltransferase activity
BIZ33_RS09705	COG0517	IMP dehydrogenase activity
BIZ33_RS09715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIZ33_RS09720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BIZ33_RS09725	COG1719	4-vinyl reductase, 4VR
BIZ33_RS09730	COG3118	belongs to the thioredoxin family
BIZ33_RS09735	COG1193	negative regulation of DNA recombination
BIZ33_RS09745	COG3906	Belongs to the UPF0473 family
BIZ33_RS09750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIZ33_RS09755	COG4472	Bacterial protein of unknown function (DUF965)
BIZ33_RS09760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIZ33_RS09765	COG0513	Belongs to the DEAD box helicase family
BIZ33_RS09770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIZ33_RS09775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ33_RS09780	COG1862	Preprotein translocase
BIZ33_RS09785	COG0343	queuine tRNA-ribosyltransferase activity
BIZ33_RS09790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIZ33_RS09795	COG2255	four-way junction helicase activity
BIZ33_RS09800	COG0632	four-way junction helicase activity
BIZ33_RS09830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIZ33_RS09835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIZ33_RS09840	COG1692	metallophosphoesterase
BIZ33_RS09845	COG1418	mRNA catabolic process
BIZ33_RS09850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BIZ33_RS09855	COG1546	Belongs to the CinA family
BIZ33_RS09855	COG1058	Belongs to the CinA family
BIZ33_RS09860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIZ33_RS09865	COG1426	Protein conserved in bacteria
BIZ33_RS09870	COG0612	Peptidase, M16
BIZ33_RS09875	COG0612	Peptidase, M16
BIZ33_RS09880	COG0527	aspartate kinase activity
BIZ33_RS09890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ33_RS09895	COG1126	abc transporter atp-binding protein
BIZ33_RS09900	COG0765	amino acid transport
BIZ33_RS09905	COG2894	cell division
BIZ33_RS09910	COG0850	regulation of cytokinetic process
BIZ33_RS09920	COG1792	Involved in formation and maintenance of cell shape
BIZ33_RS09925	COG1077	Cell shape determining protein MreB Mrl
BIZ33_RS09930	COG2003	Belongs to the UPF0758 family
BIZ33_RS09935	COG0285	dihydrofolate synthase activity
BIZ33_RS09940	COG0525	valine-tRNA ligase activity
BIZ33_RS09950	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ33_RS09950	COG2918	glutathione biosynthetic process
BIZ33_RS09955	COG0301	tRNA thio-modification
BIZ33_RS09960	COG1104	cysteine desulfurase activity
BIZ33_RS09970	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIZ33_RS09975	COG1956	GAF domain-containing protein
BIZ33_RS09980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIZ33_RS09985	COG4493	Belongs to the UPF0637 family
BIZ33_RS10000	COG0640	Transcriptional regulator
BIZ33_RS10005	COG2918	glutathione biosynthetic process
BIZ33_RS10005	COG0189	ligase activity
BIZ33_RS10010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ33_RS10025	COG0589	response to stress
BIZ33_RS10045	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ33_RS10065	COG1464	Belongs to the NlpA lipoprotein family
BIZ33_RS10070	COG2011	ABC-type metal ion transport system permease component
BIZ33_RS10075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIZ33_RS10080	COG0509	glycine decarboxylation via glycine cleavage system
BIZ33_RS10085	COG0772	Belongs to the SEDS family
BIZ33_RS10095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BIZ33_RS10100	COG1077	Cell shape determining protein MreB Mrl
BIZ33_RS10110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ33_RS10115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIZ33_RS10120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIZ33_RS10125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIZ33_RS10130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIZ33_RS10135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ33_RS10140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIZ33_RS10145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ33_RS10150	COG0356	it plays a direct role in the translocation of protons across the membrane
BIZ33_RS10155	COG2233	PERMEase
BIZ33_RS10165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIZ33_RS10170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIZ33_RS10175	COG0009	L-threonylcarbamoyladenylate synthase
BIZ33_RS10180	COG2890	protein-(glutamine-N5) methyltransferase activity
BIZ33_RS10185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIZ33_RS10190	COG1435	thymidine kinase activity
BIZ33_RS10195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIZ33_RS10200	COG3442	glutamine amidotransferase
BIZ33_RS10205	COG1482	cell wall glycoprotein biosynthetic process
BIZ33_RS10210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ33_RS10220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIZ33_RS10235	COG1132	(ABC) transporter
BIZ33_RS10255	COG0726	polysaccharide deacetylase
BIZ33_RS10300	COG4695	Portal protein
BIZ33_RS10370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BIZ33_RS10395	COG4886	Leucine-rich repeat (LRR) protein
BIZ33_RS10395	COG4932	domain protein
BIZ33_RS10440	COG1132	(ABC) transporter
BIZ33_RS10450	COG1136	(ABC) transporter
BIZ33_RS10450	COG0577	efflux transmembrane transporter activity
BIZ33_RS10460	COG0166	Belongs to the GPI family
BIZ33_RS10465	COG4975	Glucose uptake
BIZ33_RS10470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BIZ33_RS10475	COG5002	protein histidine kinase activity
BIZ33_RS10475	COG3850	Histidine kinase
BIZ33_RS10480	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS10485	COG2848	UPF0210 protein
BIZ33_RS10490	COG3830	Belongs to the UPF0237 family
BIZ33_RS10565	COG0477	Major facilitator Superfamily
BIZ33_RS10585	COG0791	NLP P60 protein
BIZ33_RS10590	COG1522	sequence-specific DNA binding
BIZ33_RS10610	COG0488	(ABC) transporter
BIZ33_RS10640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS10640	COG1263	PTS System
BIZ33_RS10640	COG2190	(PTS) system
BIZ33_RS10645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIZ33_RS10650	COG1307	EDD domain protein, DegV family
BIZ33_RS10660	COG2873	o-acetylhomoserine
BIZ33_RS10665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BIZ33_RS10680	COG4120	Belongs to the binding-protein-dependent transport system permease family
BIZ33_RS10690	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS10700	COG2084	Dehydrogenase
BIZ33_RS10705	COG0861	Integral membrane protein TerC family
BIZ33_RS10710	COG0110	maltose O-acetyltransferase activity
BIZ33_RS10715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIZ33_RS10720	COG0140	phosphoribosyl-ATP diphosphatase activity
BIZ33_RS10725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIZ33_RS10730	COG0107	imidazoleglycerol-phosphate synthase activity
BIZ33_RS10735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIZ33_RS10740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIZ33_RS10745	COG0131	Imidazoleglycerol-phosphate dehydratase
BIZ33_RS10750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIZ33_RS10755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BIZ33_RS10760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIZ33_RS10765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BIZ33_RS10785	COG0789	Transcriptional regulator
BIZ33_RS10800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIZ33_RS10815	COG3548	integral membrane protein
BIZ33_RS10835	COG1368	sulfuric ester hydrolase activity
BIZ33_RS10840	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ33_RS10850	COG0492	ferredoxin-NADP+ reductase activity
BIZ33_RS10865	COG2326	polyphosphate kinase activity
BIZ33_RS10870	COG0778	Nitroreductase
BIZ33_RS10880	COG0328	RNA-DNA hybrid ribonuclease activity
BIZ33_RS10885	COG4975	Glucose uptake
BIZ33_RS10900	COG1349	DNA-binding transcription factor activity
BIZ33_RS10905	COG1882	Formate acetyltransferase
BIZ33_RS10920	COG0561	phosphatase activity
BIZ33_RS10925	COG1609	Transcriptional regulator
BIZ33_RS10930	COG1737	Transcriptional regulator
BIZ33_RS10935	COG0673	inositol 2-dehydrogenase activity
BIZ33_RS10940	COG0673	inositol 2-dehydrogenase activity
BIZ33_RS10945	COG0025	NhaP-type Na H and K H
BIZ33_RS10950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIZ33_RS10955	COG1335	isochorismatase
BIZ33_RS10965	COG1131	(ABC) transporter
BIZ33_RS10970	COG1725	Transcriptional regulator
BIZ33_RS11020	COG0028	Belongs to the TPP enzyme family
BIZ33_RS11030	COG1073	alpha beta
BIZ33_RS11035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ33_RS11040	COG0626	cystathionine gamma-synthase activity
BIZ33_RS11070	COG0095	Lipoate-protein ligase
BIZ33_RS11075	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIZ33_RS11080	COG0589	response to stress
BIZ33_RS11085	COG0564	pseudouridine synthase activity
BIZ33_RS11100	COG4640	response to antibiotic
BIZ33_RS11105	COG1396	sequence-specific DNA binding
BIZ33_RS11120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BIZ33_RS11130	COG2188	Transcriptional regulator
BIZ33_RS11135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ33_RS11145	COG1418	mRNA catabolic process
BIZ33_RS11175	COG1253	flavin adenine dinucleotide binding
BIZ33_RS11180	COG1780	Probably involved in ribonucleotide reductase function
BIZ33_RS11185	COG0025	NhaP-type Na H and K H
BIZ33_RS11190	COG2814	Major facilitator Superfamily
BIZ33_RS11195	COG0789	Transcriptional regulator
BIZ33_RS11200	COG0604	alcohol dehydrogenase
BIZ33_RS11210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIZ33_RS11220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ33_RS11225	COG0436	Aminotransferase
BIZ33_RS11230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIZ33_RS11245	COG0583	DNA-binding transcription factor activity
BIZ33_RS11250	COG0702	epimerase
BIZ33_RS11260	COG1074	ATP-dependent DNA helicase activity
BIZ33_RS11265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BIZ33_RS11275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIZ33_RS11280	COG0284	orotidine-5'-phosphate decarboxylase activity
BIZ33_RS11285	COG0167	dihydroorotate dehydrogenase activity
BIZ33_RS11290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ33_RS11295	COG0505	Belongs to the CarA family
BIZ33_RS11300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIZ33_RS11305	COG0540	Belongs to the ATCase OTCase family
BIZ33_RS11310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIZ33_RS11315	COG2508	Transcriptional regulator
BIZ33_RS11320	COG2233	PERMEase
BIZ33_RS11325	COG2252	PERMEase
BIZ33_RS11345	COG1215	transferase activity, transferring glycosyl groups
BIZ33_RS11355	COG0151	Belongs to the GarS family
BIZ33_RS11360	COG0138	bifunctional purine biosynthesis protein purh
BIZ33_RS11365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIZ33_RS11370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIZ33_RS11380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ33_RS11385	COG0047	phosphoribosylformylglycinamidine synthase activity
BIZ33_RS11390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ33_RS11395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BIZ33_RS11400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIZ33_RS11410	COG3976	FMN-binding domain protein
BIZ33_RS11410	COG1053	succinate dehydrogenase
BIZ33_RS11410	COG0431	NADPH-dependent FMN reductase
BIZ33_RS11415	COG0431	NADPH-dependent FMN reductase
BIZ33_RS11415	COG1053	succinate dehydrogenase
BIZ33_RS11415	COG3976	FMN-binding domain protein
BIZ33_RS11420	COG0095	Lipoate-protein ligase
BIZ33_RS11425	COG2365	Tyrosine phosphatase family
BIZ33_RS11445	COG1136	(ABC) transporter
BIZ33_RS11460	COG1725	Transcriptional regulator
BIZ33_RS11465	COG1131	(ABC) transporter
BIZ33_RS11475	COG0589	response to stress
BIZ33_RS11485	COG2246	polysaccharide biosynthetic process
BIZ33_RS11505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIZ33_RS11525	COG0366	Alpha amylase catalytic
BIZ33_RS11535	COG0561	phosphatase activity
BIZ33_RS11545	COG0110	maltose O-acetyltransferase activity
BIZ33_RS11550	COG0494	nUDIX hydrolase
BIZ33_RS11585	COG1827	regulation of RNA biosynthetic process
BIZ33_RS11590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIZ33_RS11595	COG1309	transcriptional regulator
BIZ33_RS11605	COG1131	(ABC) transporter
BIZ33_RS11610	COG3048	D-serine ammonia-lyase activity
BIZ33_RS11615	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS11620	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS11625	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ33_RS11630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS11635	COG2188	Transcriptional regulator
BIZ33_RS11640	COG1216	Glycosyl transferase, family 2
BIZ33_RS11655	COG0561	phosphatase activity
BIZ33_RS11660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIZ33_RS11685	COG0716	FMN binding
BIZ33_RS11705	COG0710	3-dehydroquinate dehydratase activity
BIZ33_RS11710	COG0531	amino acid
BIZ33_RS11755	COG4720	Psort location CytoplasmicMembrane, score
BIZ33_RS11760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIZ33_RS11775	COG4990	cell redox homeostasis
BIZ33_RS11805	COG0789	Transcriptional regulator
BIZ33_RS11805	COG4978	Transcriptional regulator
BIZ33_RS11820	COG0577	efflux transmembrane transporter activity
BIZ33_RS11825	COG1136	(ABC) transporter
BIZ33_RS11870	COG2814	Major facilitator Superfamily
BIZ33_RS11880	COG2814	Major facilitator Superfamily
BIZ33_RS11890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIZ33_RS11895	COG2855	membrane
BIZ33_RS11900	COG0583	DNA-binding transcription factor activity
BIZ33_RS11910	COG0438	transferase activity, transferring glycosyl groups
BIZ33_RS11925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIZ33_RS11940	COG4152	abc transporter atp-binding protein
BIZ33_RS11950	COG4221	oxidoreductase activity
BIZ33_RS11965	COG0789	Transcriptional regulator
BIZ33_RS11985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIZ33_RS12010	COG0456	acetyltransferase
BIZ33_RS12035	COG0583	DNA-binding transcription factor activity
BIZ33_RS12045	COG1063	alcohol dehydrogenase
BIZ33_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS12065	COG0589	response to stress
BIZ33_RS12070	COG0110	maltose O-acetyltransferase activity
BIZ33_RS12075	COG1011	Hydrolase
BIZ33_RS12090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIZ33_RS12100	COG0667	Aldo Keto reductase
BIZ33_RS12105	COG1132	(ABC) transporter
BIZ33_RS12110	COG1132	(ABC) transporter
BIZ33_RS12115	COG2814	Major facilitator Superfamily
BIZ33_RS12130	COG1511	domain protein
BIZ33_RS12130	COG1511	domain protein
BIZ33_RS12140	COG0640	Transcriptional regulator
BIZ33_RS12170	COG0488	(ABC) transporter
BIZ33_RS12175	COG0561	phosphatase activity
BIZ33_RS12185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ33_RS12200	COG2270	Major facilitator Superfamily
BIZ33_RS12240	COG2200	EAL domain
BIZ33_RS12250	COG1328	CTP reductase activity
BIZ33_RS12260	COG0242	peptide deformylase activity
BIZ33_RS12270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ33_RS12300	COG0583	DNA-binding transcription factor activity
BIZ33_RS12310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BIZ33_RS12370	COG0697	spore germination
BIZ33_RS12395	COG1940	carbohydrate kinase activity
BIZ33_RS12400	COG1132	(ABC) transporter
BIZ33_RS12410	COG0778	Nitroreductase
BIZ33_RS12415	COG2190	(PTS) system
BIZ33_RS12415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS12415	COG1263	PTS System
BIZ33_RS12420	COG1116	anion transmembrane transporter activity
BIZ33_RS12425	COG4120	Belongs to the binding-protein-dependent transport system permease family
BIZ33_RS12455	COG0617	tRNA 3'-terminal CCA addition
BIZ33_RS12455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIZ33_RS12455	COG3620	sequence-specific DNA binding
BIZ33_RS12460	COG0410	ABC transporter
BIZ33_RS12490	COG5549	protein import
BIZ33_RS12490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ33_RS12495	COG2246	polysaccharide biosynthetic process
BIZ33_RS12505	COG1914	H( )-stimulated, divalent metal cation uptake system
BIZ33_RS12525	COG0640	Transcriptional regulator
BIZ33_RS12535	COG1136	(ABC) transporter
BIZ33_RS12535	COG0577	efflux transmembrane transporter activity
BIZ33_RS12570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS12575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS12580	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS12590	COG0789	Transcriptional regulator
BIZ33_RS12595	COG0741	lytic transglycosylase activity
BIZ33_RS12615	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIZ33_RS12640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ33_RS12655	COG4221	oxidoreductase activity
BIZ33_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS12700	COG1132	(ABC) transporter
BIZ33_RS12705	COG1132	(ABC) transporter
BIZ33_RS12710	COG1473	amidohydrolase
BIZ33_RS12715	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS12730	COG0531	amino acid
BIZ33_RS12755	COG2217	Heavy metal translocating P-type atpase
BIZ33_RS12815	COG1063	alcohol dehydrogenase
BIZ33_RS12855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ33_RS12860	COG1733	regulation of RNA biosynthetic process
BIZ33_RS12865	COG2814	Major facilitator Superfamily
BIZ33_RS12875	COG0367	asparagine synthase
BIZ33_RS12880	COG3279	Response regulator of the LytR AlgR family
BIZ33_RS12895	COG1309	transcriptional regulator
BIZ33_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
BIZ33_RS12920	COG1733	regulation of RNA biosynthetic process
BIZ33_RS12925	COG0300	oxidoreductase activity
BIZ33_RS12945	COG4989	oxidoreductase activity
BIZ33_RS12960	COG0477	Major facilitator Superfamily
BIZ33_RS12970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIZ33_RS12975	COG1120	ATPase activity
BIZ33_RS12980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ33_RS12985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ33_RS12990	COG1309	transcriptional regulator
BIZ33_RS13000	COG0640	Transcriptional regulator
BIZ33_RS13005	COG2814	Major facilitator Superfamily
BIZ33_RS13010	COG4221	oxidoreductase activity
BIZ33_RS13015	COG0110	maltose O-acetyltransferase activity
BIZ33_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ33_RS13060	COG0481	GTPase activity
BIZ33_RS13070	COG2816	NAD+ diphosphatase activity
BIZ33_RS13080	COG0431	NADPH-dependent FMN reductase
BIZ33_RS13080	COG3976	FMN-binding domain protein
BIZ33_RS13080	COG1053	succinate dehydrogenase
BIZ33_RS13090	COG0783	Belongs to the Dps family
BIZ33_RS13105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS13125	COG0789	Transcriptional regulator
BIZ33_RS13140	COG0693	protein deglycase activity
BIZ33_RS13175	COG1136	(ABC) transporter
BIZ33_RS13175	COG0577	efflux transmembrane transporter activity
BIZ33_RS13185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BIZ33_RS13200	COG1376	ErfK ybiS ycfS ynhG family protein
BIZ33_RS13205	COG0656	L-ascorbic acid biosynthetic process
BIZ33_RS13220	COG0477	Major facilitator Superfamily
BIZ33_RS13250	COG0588	phosphoglycerate mutase activity
BIZ33_RS13255	COG0628	permease
BIZ33_RS13270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BIZ33_RS13280	COG2815	serine threonine protein kinase
BIZ33_RS13280	COG0515	serine threonine protein kinase
BIZ33_RS13320	COG1247	-acetyltransferase
BIZ33_RS13325	COG1686	Belongs to the peptidase S11 family
BIZ33_RS13345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIZ33_RS13350	COG0517	IMP dehydrogenase activity
BIZ33_RS13350	COG0516	GMP reductase activity
BIZ33_RS13360	COG0012	GTP binding
BIZ33_RS13365	COG4481	Protein conserved in bacteria
BIZ33_RS13370	COG1475	DNA binding
BIZ33_RS13375	COG1192	Involved in chromosome partitioning
BIZ33_RS13385	COG0357	Ribosomal RNA small subunit methyltransferase G
BIZ33_RS13390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIZ33_RS13400	COG0583	DNA-binding transcription factor activity
BIZ33_RS13405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ33_RS13410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ33_RS13415	COG0765	amino acid transport
BIZ33_RS13420	COG1126	abc transporter atp-binding protein
BIZ33_RS13425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ33_RS13450	COG2190	(PTS) system
BIZ33_RS13450	COG1263	PTS System
BIZ33_RS13450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS13455	COG0366	Alpha amylase catalytic
BIZ33_RS13460	COG1609	Transcriptional regulator
BIZ33_RS13470	COG0390	transport system, permease component
BIZ33_RS13475	COG4619	ABC transporter
BIZ33_RS13480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIZ33_RS13495	COG0561	phosphatase activity
BIZ33_RS13510	COG1263	PTS System
BIZ33_RS13510	COG2190	(PTS) system
BIZ33_RS13510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS13540	COG0735	belongs to the Fur family
BIZ33_RS13565	COG1380	Effector of murein hydrolase LrgA
BIZ33_RS13575	COG1307	EDD domain protein, DegV family
BIZ33_RS13585	COG2738	Putative neutral zinc metallopeptidase
BIZ33_RS13590	COG1233	COG1233 Phytoene dehydrogenase and related
BIZ33_RS13595	COG1562	ergosterol biosynthetic process
BIZ33_RS13605	COG1929	Belongs to the glycerate kinase type-1 family
BIZ33_RS13620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIZ33_RS13625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIZ33_RS13630	COG0516	GMP reductase activity
BIZ33_RS13635	COG2365	Tyrosine phosphatase family
BIZ33_RS13640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ33_RS13650	COG0531	amino acid
BIZ33_RS13655	COG3158	transport of potassium into the cell
BIZ33_RS13660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIZ33_RS13665	COG0628	permease
BIZ33_RS13670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ33_RS13685	COG1272	protein, Hemolysin III
BIZ33_RS13690	COG0640	Transcriptional regulator
BIZ33_RS13725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIZ33_RS13735	COG0302	gtp cyclohydrolase
BIZ33_RS13740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIZ33_RS13760	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIZ33_RS13765	COG2814	Major facilitator Superfamily
BIZ33_RS13795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ33_RS13800	COG1882	Formate acetyltransferase
BIZ33_RS13805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIZ33_RS13815	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ33_RS13820	COG4989	oxidoreductase activity
BIZ33_RS13850	COG2217	Heavy metal translocating P-type atpase
BIZ33_RS13860	COG2315	Protein conserved in bacteria
BIZ33_RS13870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIZ33_RS13875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ33_RS13885	COG1757	Na H antiporter
BIZ33_RS13890	COG1113	amino acid transport
BIZ33_RS13900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIZ33_RS13915	COG1393	Belongs to the ArsC family
BIZ33_RS13920	COG3189	MarR family transcriptional regulator
BIZ33_RS13930	COG1194	a g-specific adenine glycosylase
BIZ33_RS13945	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ33_RS13965	COG0697	spore germination
BIZ33_RS14005	COG0477	Major facilitator Superfamily
BIZ33_RS14065	COG0737	Belongs to the 5'-nucleotidase family
BIZ33_RS14075	COG0656	L-ascorbic acid biosynthetic process
BIZ33_RS14095	COG1968	undecaprenyl-diphosphatase activity
BIZ33_RS14100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BIZ33_RS14135	COG2207	Transcriptional regulator
BIZ33_RS14160	COG0076	glutamate decarboxylase activity
BIZ33_RS14200	COG1309	transcriptional regulator
BIZ33_RS14210	COG2226	methyltransferase
BIZ33_RS14230	COG2217	Heavy metal translocating P-type atpase
BIZ33_RS14235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS14240	COG3118	belongs to the thioredoxin family
BIZ33_RS14245	COG1937	Protein conserved in bacteria
BIZ33_RS14265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ33_RS14270	COG3590	peptidase
BIZ33_RS14295	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS14355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ33_RS14365	COG1114	Component of the transport system for branched-chain amino acids
BIZ33_RS14375	COG1874	Beta-galactosidase
BIZ33_RS14380	COG1609	Transcriptional regulator
BIZ33_RS14390	COG0477	Major facilitator Superfamily
BIZ33_RS14410	COG2184	nucleotidyltransferase activity
BIZ33_RS14415	COG2944	sequence-specific DNA binding
BIZ33_RS14420	COG1609	Transcriptional regulator
BIZ33_RS14425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BIZ33_RS14430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIZ33_RS14435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIZ33_RS14455	COG2190	(PTS) system
BIZ33_RS14455	COG2211	Major facilitator Superfamily
BIZ33_RS14460	COG2017	converts alpha-aldose to the beta-anomer
BIZ33_RS14465	COG1609	Transcriptional regulator
BIZ33_RS14470	COG0667	Aldo Keto reductase
BIZ33_RS14490	COG0710	3-dehydroquinate dehydratase activity
BIZ33_RS14495	COG0738	Major facilitator superfamily
BIZ33_RS14500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIZ33_RS14505	COG0583	DNA-binding transcription factor activity
BIZ33_RS14510	COG0738	Major facilitator superfamily
BIZ33_RS14520	COG2267	carboxylic ester hydrolase activity
BIZ33_RS14525	COG2188	Transcriptional regulator
BIZ33_RS14530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ33_RS14535	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIZ33_RS14540	COG2971	BadF BadG BcrA BcrD
BIZ33_RS14550	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS14560	COG3711	transcriptional antiterminator
BIZ33_RS14565	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS14570	COG2723	6-phospho-beta-galactosidase activity
BIZ33_RS14575	COG1263	PTS System
BIZ33_RS14575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ33_RS14575	COG2190	(PTS) system
BIZ33_RS14595	COG2211	Major facilitator Superfamily
BIZ33_RS14610	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BIZ33_RS14625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIZ33_RS14630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ33_RS14635	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BIZ33_RS14635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ33_RS14635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ33_RS14640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ33_RS14655	COG3711	transcriptional antiterminator
BIZ33_RS14670	COG3775	system Galactitol-specific IIC component
BIZ33_RS14675	COG3414	Phosphotransferase system galactitol-specific IIB component
BIZ33_RS14685	COG1349	DNA-binding transcription factor activity
BIZ33_RS14690	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BIZ33_RS14700	COG0110	maltose O-acetyltransferase activity
BIZ33_RS14705	COG2160	L-arabinose isomerase activity
BIZ33_RS14725	COG1609	Transcriptional regulator
BIZ33_RS14730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIZ33_RS14760	COG2261	transglycosylase associated protein
BIZ33_RS14770	COG1393	Belongs to the ArsC family
BIZ33_RS14790	COG4512	PFAM Accessory gene regulator B
BIZ33_RS14805	COG0383	alpha-mannosidase activity
BIZ33_RS14815	COG2188	Transcriptional regulator
BIZ33_RS14825	COG3842	ATPase activity
BIZ33_RS14835	COG2207	Transcriptional regulator
BIZ33_RS14835	COG4753	response regulator
BIZ33_RS14840	COG2972	Histidine kinase
BIZ33_RS14850	COG0366	Alpha amylase catalytic
BIZ33_RS14855	COG1653	transport
BIZ33_RS14860	COG0395	ABC-type sugar transport system, permease component
BIZ33_RS14875	COG2207	Transcriptional regulator
BIZ33_RS14875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIZ33_RS14885	COG1132	(ABC) transporter
BIZ33_RS14890	COG2188	Transcriptional regulator
BIZ33_RS14905	COG3732	PTS system glucitol sorbitol-specific
BIZ33_RS14910	COG3730	PTS system glucitol sorbitol-specific
BIZ33_RS14930	COG4975	Glucose uptake
BIZ33_RS14935	COG1869	D-ribose catabolic process
BIZ33_RS14945	COG1609	Transcriptional regulator
BIZ33_RS14950	COG1012	belongs to the aldehyde dehydrogenase family
BIZ33_RS14950	COG1454	alcohol dehydrogenase
BIZ33_RS14960	COG1695	Transcriptional regulator
BIZ33_RS14965	COG3479	Phenolic acid decarboxylase
BIZ33_RS14980	COG1307	EDD domain protein, DegV family
BIZ33_RS15025	COG0445	tRNA wobble uridine modification
BIZ33_RS15030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIZ33_RS15035	COG1847	R3H domain protein
BIZ33_RS15045	COG4166	transmembrane transport
BIZ33_RS15050	COG0706	membrane insertase activity
BIZ33_RS15055	COG0594	ribonuclease P activity
BIZ33_RS15060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BIZ33_RS15105	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ33_RS15120	COG0463	Glycosyl transferase, family 2
BIZ33_RS15190	COG2814	Major facilitator Superfamily
BIZ33_RS15205	COG2217	Heavy metal translocating P-type atpase
BIZ33_RS15215	COG0745	RESPONSE REGULATOR receiver
BIZ33_RS15220	COG5002	protein histidine kinase activity
BIZ33_RS15225	COG0586	Pfam SNARE associated Golgi protein
BIZ33_RS15235	COG0463	Glycosyl transferase, family 2
BIZ33_RS15300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ33_RS15330	COG3189	MarR family transcriptional regulator
BIZ33_RS15335	COG2826	transposase and inactivated derivatives, IS30 family
BIZ33_RS15345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ33_RS15360	COG0477	Major facilitator Superfamily
BIZ33_RS15365	COG1418	mRNA catabolic process
BIZ33_RS15385	COG0551	DNA topoisomerase type I activity
BIZ33_RS15385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ33_RS15525	COG2261	transglycosylase associated protein
BIZ33_RS15560	COG0693	protein deglycase activity
BIZ33_RS15565	COG1733	regulation of RNA biosynthetic process
BIZ33_RS15570	COG3328	transposase activity
BIZ33_RS15585	COG0577	efflux transmembrane transporter activity
BIZ33_RS15585	COG1136	(ABC) transporter
BIZ33_RS15590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIZ33_RS15640	COG2261	transglycosylase associated protein
BIZ33_RS15660	COG0028	Belongs to the TPP enzyme family
BIZ33_RS15690	COG2124	cytochrome p450