locus-tag	class	description
ALX04_RS00015	COG0572	uridine kinase
ALX04_RS00030	COG0583	DNA-binding transcription factor activity
ALX04_RS00035	COG1053	succinate dehydrogenase
ALX04_RS00045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ALX04_RS00050	COG0017	Asparaginyl-tRNA synthetase
ALX04_RS00055	COG2502	aspartate--ammonia ligase
ALX04_RS00060	COG4690	dipeptidase activity
ALX04_RS00080	COG0514	ATP-dependent DNA helicase (RecQ)
ALX04_RS00085	COG0564	pseudouridine synthase activity
ALX04_RS00090	COG0640	Transcriptional regulator
ALX04_RS00140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALX04_RS00145	COG0527	aspartate kinase activity
ALX04_RS00150	COG0367	asparagine synthase
ALX04_RS00210	COG2814	Major facilitator Superfamily
ALX04_RS00230	COG1278	Cold shock
ALX04_RS00235	COG2966	Psort location CytoplasmicMembrane, score
ALX04_RS00245	COG1316	TRANSCRIPTIONal
ALX04_RS00265	COG1959	2 iron, 2 sulfur cluster binding
ALX04_RS00270	COG0028	Belongs to the TPP enzyme family
ALX04_RS00275	COG0833	amino acid
ALX04_RS00285	COG1428	Deoxynucleoside kinase
ALX04_RS00290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALX04_RS00330	COG4463	regulation of RNA biosynthetic process
ALX04_RS00345	COG0085	RNA polymerase activity
ALX04_RS00350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALX04_RS00355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ALX04_RS00360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALX04_RS00365	COG0049	tRNA binding
ALX04_RS00370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ALX04_RS00375	COG0051	transcription antitermination factor activity, RNA binding
ALX04_RS00380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALX04_RS00385	COG0088	Forms part of the polypeptide exit tunnel
ALX04_RS00390	COG0089	rRNA binding
ALX04_RS00395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALX04_RS00400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALX04_RS00405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALX04_RS00410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALX04_RS00415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALX04_RS00420	COG0255	Belongs to the universal ribosomal protein uL29 family
ALX04_RS00425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ALX04_RS00430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ALX04_RS00435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALX04_RS00440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALX04_RS00445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALX04_RS00450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALX04_RS00455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ALX04_RS00460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALX04_RS00465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALX04_RS00470	COG1841	ribosomal large subunit assembly
ALX04_RS00475	COG0200	Binds to the 23S rRNA
ALX04_RS00485	COG0563	adenylate kinase activity
ALX04_RS00490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALX04_RS00495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ALX04_RS00500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALX04_RS00505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALX04_RS00510	COG0202	RNA polymerase activity
ALX04_RS00515	COG0203	ribosomal protein L17
ALX04_RS00540	COG4939	FMN-binding domain protein
ALX04_RS00550	COG1122	ATPase activity
ALX04_RS00555	COG1122	ATPase activity
ALX04_RS00565	COG0101	tRNA pseudouridine synthase activity
ALX04_RS00570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ALX04_RS00575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALX04_RS00595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ALX04_RS00600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALX04_RS00605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ALX04_RS00610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ALX04_RS00620	COG2151	metal-sulfur cluster biosynthetic enzyme
ALX04_RS00625	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ALX04_RS00635	COG4977	sequence-specific DNA binding
ALX04_RS00635	COG1917	Cupin 2, conserved barrel domain protein
ALX04_RS00640	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ALX04_RS00645	COG1121	(ABC) transporter
ALX04_RS00650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALX04_RS00655	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALX04_RS00665	COG0039	L-malate dehydrogenase activity
ALX04_RS00670	COG0471	metal ion transport
ALX04_RS00690	COG3052	prosthetic group binding
ALX04_RS00705	COG2826	transposase and inactivated derivatives, IS30 family
ALX04_RS00740	COG0114	fumarate hydratase activity
ALX04_RS00745	COG1053	succinate dehydrogenase
ALX04_RS00755	COG0583	DNA-binding transcription factor activity
ALX04_RS00760	COG0583	DNA-binding transcription factor activity
ALX04_RS00765	COG0281	malic enzyme
ALX04_RS00775	COG0531	amino acid
ALX04_RS00780	COG4684	Psort location CytoplasmicMembrane, score
ALX04_RS00795	COG1271	oxidase subunit
ALX04_RS00800	COG1294	oxidase, subunit
ALX04_RS00805	COG4988	ABC transporter
ALX04_RS00810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ALX04_RS00825	COG0142	geranyltranstransferase activity
ALX04_RS00840	COG1705	Flagellar rod assembly protein muramidase FlgJ
ALX04_RS00845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALX04_RS00850	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ALX04_RS00855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ALX04_RS00865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALX04_RS00870	COG4851	CamS sex pheromone cAM373 precursor
ALX04_RS00875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALX04_RS00880	COG0154	amidase activity
ALX04_RS00885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALX04_RS00890	COG1597	lipid kinase activity
ALX04_RS00895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALX04_RS00910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS00920	COG1737	Transcriptional regulator
ALX04_RS00935	COG1278	Cold shock
ALX04_RS00940	COG0673	inositol 2-dehydrogenase activity
ALX04_RS00945	COG0513	Belongs to the DEAD box helicase family
ALX04_RS00960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS00985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ALX04_RS00995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALX04_RS01005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS01035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALX04_RS01035	COG1215	transferase activity, transferring glycosyl groups
ALX04_RS01040	COG0110	maltose O-acetyltransferase activity
ALX04_RS01070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALX04_RS01080	COG1088	dTDP-glucose 4,6-dehydratase activity
ALX04_RS01085	COG1091	dTDP-4-dehydrorhamnose reductase activity
ALX04_RS01095	COG0582	viral genome integration into host DNA
ALX04_RS01105	COG0489	protein tyrosine kinase activity
ALX04_RS01110	COG4464	protein tyrosine phosphatase activity
ALX04_RS01115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALX04_RS01135	COG1216	Glycosyl transferase, family 2
ALX04_RS01145	COG2244	polysaccharide biosynthetic process
ALX04_RS01150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALX04_RS01180	COG0562	UDP-galactopyranose mutase
ALX04_RS01220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALX04_RS01265	COG2137	regulation of response to DNA damage stimulus
ALX04_RS01270	COG3557	Belongs to the UPF0374 family
ALX04_RS01300	COG0628	permease
ALX04_RS01305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALX04_RS01310	COG2610	gluconate transmembrane transporter activity
ALX04_RS01315	COG1070	Carbohydrate kinase
ALX04_RS01320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ALX04_RS01325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALX04_RS01330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ALX04_RS01365	COG4166	transmembrane transport
ALX04_RS01370	COG0601	transmembrane transport
ALX04_RS01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALX04_RS01380	COG0444	Belongs to the ABC transporter superfamily
ALX04_RS01385	COG4608	Belongs to the ABC transporter superfamily
ALX04_RS01395	COG0582	viral genome integration into host DNA
ALX04_RS01400	COG0542	response to heat
ALX04_RS01420	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS01425	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS01435	COG1686	Belongs to the peptidase S11 family
ALX04_RS01440	COG0436	Aminotransferase
ALX04_RS01445	COG4703	Protein of unknown function (DUF1797)
ALX04_RS01450	COG1368	sulfuric ester hydrolase activity
ALX04_RS01540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALX04_RS01560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALX04_RS01575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALX04_RS01580	COG0833	amino acid
ALX04_RS01585	COG2040	homocysteine
ALX04_RS01590	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS01600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALX04_RS01605	COG0477	Major facilitator Superfamily
ALX04_RS01620	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS01640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ALX04_RS01650	COG0495	leucyl-tRNA aminoacylation
ALX04_RS01655	COG2244	polysaccharide biosynthetic process
ALX04_RS01660	COG1187	pseudouridine synthase activity
ALX04_RS01665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALX04_RS01670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALX04_RS01680	COG3842	ATPase activity
ALX04_RS01685	COG1175	transmembrane transport
ALX04_RS01690	COG0395	ABC-type sugar transport system, permease component
ALX04_RS01700	COG0584	glycerophosphoryl diester phosphodiesterase
ALX04_RS01705	COG1428	Deoxynucleoside kinase
ALX04_RS01710	COG1970	mechanosensitive ion channel activity
ALX04_RS01745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALX04_RS01750	COG0789	Transcriptional regulator
ALX04_RS01760	COG0697	spore germination
ALX04_RS01765	COG0561	phosphatase activity
ALX04_RS01785	COG3279	Response regulator of the LytR AlgR family
ALX04_RS01805	COG1846	Transcriptional regulator
ALX04_RS01820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALX04_RS01860	COG0646	methionine synthase
ALX04_RS01860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ALX04_RS01865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ALX04_RS01875	COG2046	Belongs to the sulfate adenylyltransferase family
ALX04_RS01880	COG0529	Catalyzes the synthesis of activated sulfate
ALX04_RS01885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALX04_RS01895	COG3273	potassium ion transport
ALX04_RS01895	COG0471	metal ion transport
ALX04_RS01900	COG0534	Mate efflux family protein
ALX04_RS01920	COG2153	protein acetylation
ALX04_RS01925	COG0018	arginyl-trna synthetase
ALX04_RS01935	COG1136	(ABC) transporter
ALX04_RS01935	COG0577	efflux transmembrane transporter activity
ALX04_RS01965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS01970	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS01980	COG1376	ErfK ybiS ycfS ynhG family protein
ALX04_RS01985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALX04_RS01990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALX04_RS02000	COG0436	Aminotransferase
ALX04_RS02005	COG1438	arginine binding
ALX04_RS02015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALX04_RS02020	COG3679	Belongs to the UPF0342 family
ALX04_RS02025	COG0420	3'-5' exonuclease activity
ALX04_RS02030	COG4717	serine-type aminopeptidase activity
ALX04_RS02035	COG3481	metal-dependent phosphohydrolase, HD sub domain
ALX04_RS02050	COG0583	DNA-binding transcription factor activity
ALX04_RS02060	COG3976	FMN-binding domain protein
ALX04_RS02060	COG1053	succinate dehydrogenase
ALX04_RS02060	COG0431	NADPH-dependent FMN reductase
ALX04_RS02080	COG0463	Glycosyl transferase, family 2
ALX04_RS02100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALX04_RS02100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALX04_RS02105	COG0307	riboflavin synthase, alpha
ALX04_RS02110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALX04_RS02110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALX04_RS02115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALX04_RS02140	COG1309	transcriptional regulator
ALX04_RS02155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALX04_RS02165	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS02195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALX04_RS02205	COG0537	adenosine 5'-monophosphoramidase activity
ALX04_RS02210	COG1131	(ABC) transporter
ALX04_RS02215	COG4473	ABC transporter
ALX04_RS02220	COG0510	thiamine kinase activity
ALX04_RS02225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALX04_RS02235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALX04_RS02240	COG1674	ftsk spoiiie
ALX04_RS02245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALX04_RS02270	COG0719	Fe-S assembly protein
ALX04_RS02275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALX04_RS02285	COG0719	Fe-S assembly protein
ALX04_RS02290	COG2151	metal-sulfur cluster biosynthetic enzyme
ALX04_RS02305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALX04_RS02305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALX04_RS02310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ALX04_RS02315	COG0237	dephospho-CoA kinase activity
ALX04_RS02320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ALX04_RS02325	COG3611	Membrane attachment protein
ALX04_RS02330	COG1484	DNA-dependent DNA replication
ALX04_RS02335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ALX04_RS02340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALX04_RS02345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ALX04_RS02350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALX04_RS02360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALX04_RS02370	COG1733	regulation of RNA biosynthetic process
ALX04_RS02385	COG1215	transferase activity, transferring glycosyl groups
ALX04_RS02400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ALX04_RS02405	COG1534	Rna-binding protein
ALX04_RS02410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALX04_RS02415	COG1713	HD superfamily hydrolase involved in NAD metabolism
ALX04_RS02420	COG0799	negative regulation of ribosome biogenesis
ALX04_RS02425	COG2226	methyltransferase
ALX04_RS02430	COG1323	Belongs to the UPF0348 family
ALX04_RS02440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALX04_RS02455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ALX04_RS02465	COG0745	RESPONSE REGULATOR receiver
ALX04_RS02470	COG5002	protein histidine kinase activity
ALX04_RS02480	COG0419	ATPase involved in DNA repair
ALX04_RS02495	COG0706	membrane insertase activity
ALX04_RS02500	COG1254	Belongs to the acylphosphatase family
ALX04_RS02505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALX04_RS02515	COG1733	regulation of RNA biosynthetic process
ALX04_RS02520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALX04_RS02525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALX04_RS02525	COG0072	phenylalanine-tRNA ligase activity
ALX04_RS02530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ALX04_RS02535	COG0572	uridine kinase
ALX04_RS02540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALX04_RS02565	COG4841	protein insertion into membrane
ALX04_RS02575	COG0768	penicillin binding
ALX04_RS02580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALX04_RS02585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALX04_RS02590	COG0705	Rhomboid family
ALX04_RS02590	COG0457	Tetratricopeptide repeat
ALX04_RS02600	COG1940	carbohydrate kinase activity
ALX04_RS02620	COG0584	glycerophosphoryl diester phosphodiesterase
ALX04_RS02625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ALX04_RS02630	COG0789	Transcriptional regulator
ALX04_RS02685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALX04_RS02695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALX04_RS02700	COG0006	proline dipeptidase activity
ALX04_RS02705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALX04_RS02710	COG1302	Protein conserved in bacteria
ALX04_RS02715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALX04_RS02720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALX04_RS02725	COG1570	exodeoxyribonuclease VII activity
ALX04_RS02730	COG1722	exodeoxyribonuclease VII activity
ALX04_RS02735	COG0142	geranyltranstransferase activity
ALX04_RS02740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ALX04_RS02745	COG1438	arginine binding
ALX04_RS02750	COG0497	DNA recombination
ALX04_RS02765	COG1732	Glycine betaine
ALX04_RS02780	COG0194	GDP metabolic process
ALX04_RS02785	COG1758	RNA polymerase activity
ALX04_RS02790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ALX04_RS02795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALX04_RS02800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALX04_RS02805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALX04_RS02805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALX04_RS02810	COG0631	protein serine/threonine phosphatase activity
ALX04_RS02815	COG2815	serine threonine protein kinase
ALX04_RS02815	COG0515	serine threonine protein kinase
ALX04_RS02820	COG1162	GTPase activity
ALX04_RS02825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALX04_RS02830	COG1564	THIamine pyrophosphokinase
ALX04_RS02835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALX04_RS02840	COG1302	Protein conserved in bacteria
ALX04_RS02845	COG1461	Dihydroxyacetone kinase
ALX04_RS02850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ALX04_RS02855	COG0416	fatty acid biosynthetic process
ALX04_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALX04_RS02865	COG0571	ribonuclease III activity
ALX04_RS02870	COG1196	nuclear chromosome segregation
ALX04_RS02875	COG0552	protein localization to endoplasmic reticulum
ALX04_RS02880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ALX04_RS02885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALX04_RS02890	COG0228	four-way junction DNA binding
ALX04_RS02895	COG1837	Belongs to the UPF0109 family
ALX04_RS02900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALX04_RS02905	COG0336	Belongs to the RNA methyltransferase TrmD family
ALX04_RS02910	COG0335	large ribosomal subunit rRNA binding
ALX04_RS02930	COG1131	(ABC) transporter
ALX04_RS02945	COG0512	Glutamine amidotransferase of anthranilate synthase
ALX04_RS02945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALX04_RS02950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALX04_RS02955	COG0134	indole-3-glycerol-phosphate synthase activity
ALX04_RS02960	COG0135	phosphoribosylanthranilate isomerase activity
ALX04_RS02965	COG0133	tryptophan synthase activity
ALX04_RS02970	COG0159	tryptophan synthase activity
ALX04_RS02985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ALX04_RS02995	COG1473	amidohydrolase
ALX04_RS03000	COG1063	alcohol dehydrogenase
ALX04_RS03010	COG0300	oxidoreductase activity
ALX04_RS03020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALX04_RS03025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALX04_RS03030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALX04_RS03035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ALX04_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS03045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALX04_RS03060	COG0439	Biotin carboxylase
ALX04_RS03075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ALX04_RS03085	COG1811	Na channel or pump
ALX04_RS03090	COG0583	DNA-binding transcription factor activity
ALX04_RS03095	COG1607	acyl-coa hydrolase
ALX04_RS03100	COG1162	GTPase activity
ALX04_RS03110	COG0477	Major facilitator Superfamily
ALX04_RS03155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALX04_RS03160	COG3397	chitin binding
ALX04_RS03175	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ALX04_RS03185	COG3152	Membrane
ALX04_RS03190	COG1597	lipid kinase activity
ALX04_RS03205	COG2261	transglycosylase associated protein
ALX04_RS03210	COG3237	CsbD-like
ALX04_RS03225	COG1942	4-Oxalocrotonate Tautomerase
ALX04_RS03265	COG0531	amino acid
ALX04_RS03270	COG0561	phosphatase activity
ALX04_RS03275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ALX04_RS03275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALX04_RS03295	COG2017	converts alpha-aldose to the beta-anomer
ALX04_RS03300	COG1304	FMN binding
ALX04_RS03325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALX04_RS03325	COG1199	ATP-dependent helicase activity
ALX04_RS03340	COG0017	Asparaginyl-tRNA synthetase
ALX04_RS03355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ALX04_RS03360	COG2011	ABC-type metal ion transport system permease component
ALX04_RS03365	COG1464	Belongs to the NlpA lipoprotein family
ALX04_RS03375	COG1177	transmembrane transport
ALX04_RS03380	COG1840	ABC-type Fe3 transport system, periplasmic component
ALX04_RS03395	COG3331	DNA recombination
ALX04_RS03400	COG4474	Belongs to the UPF0398 family
ALX04_RS03405	COG3599	regulation of cell shape
ALX04_RS03415	COG0116	Belongs to the methyltransferase superfamily
ALX04_RS03425	COG0477	Major facilitator Superfamily
ALX04_RS03430	COG1073	alpha beta
ALX04_RS03440	COG1216	Glycosyl transferase, family 2
ALX04_RS03460	COG1619	proteins homologs of microcin C7 resistance protein MccF
ALX04_RS03490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALX04_RS03505	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ALX04_RS03510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALX04_RS03515	COG0564	pseudouridine synthase activity
ALX04_RS03520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALX04_RS03525	COG0505	Belongs to the CarA family
ALX04_RS03530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALX04_RS03540	COG5646	InterPro IPR014922
ALX04_RS03565	COG1131	(ABC) transporter
ALX04_RS03570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ALX04_RS03575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ALX04_RS03585	COG1307	EDD domain protein, DegV family
ALX04_RS03645	COG1113	amino acid transport
ALX04_RS03660	COG1620	l-lactate permease
ALX04_RS03670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALX04_RS03680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALX04_RS03695	COG1846	Transcriptional regulator
ALX04_RS03735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALX04_RS03740	COG1227	inorganic diphosphatase activity
ALX04_RS03745	COG0583	DNA-binding transcription factor activity
ALX04_RS03755	COG0187	DNA topoisomerase II activity
ALX04_RS03760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ALX04_RS03770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ALX04_RS03775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ALX04_RS03780	COG4974	Belongs to the 'phage' integrase family
ALX04_RS03785	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ALX04_RS03790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ALX04_RS03795	COG0758	DNA mediated transformation
ALX04_RS03800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ALX04_RS03805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ALX04_RS03815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ALX04_RS03820	COG0583	DNA-binding transcription factor activity
ALX04_RS03835	COG2814	Major facilitator Superfamily
ALX04_RS03840	COG3409	Peptidoglycan-binding domain 1 protein
ALX04_RS03840	COG0793	Belongs to the peptidase S41A family
ALX04_RS03845	COG4479	Belongs to the UPF0346 family
ALX04_RS03850	COG4698	Protein conserved in bacteria
ALX04_RS03855	COG2755	lipolytic protein G-D-S-L family
ALX04_RS03860	COG1307	EDD domain protein, DegV family
ALX04_RS03865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ALX04_RS03870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ALX04_RS03875	COG0488	(ABC) transporter
ALX04_RS03885	COG0617	tRNA 3'-terminal CCA addition
ALX04_RS03890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALX04_RS03895	COG0561	phosphatase activity
ALX04_RS03900	COG0457	Tetratricopeptide repeat
ALX04_RS03915	COG1160	GTP binding
ALX04_RS03920	COG0539	negative regulation of cytoplasmic translation
ALX04_RS03925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ALX04_RS03935	COG0514	ATP-dependent DNA helicase (RecQ)
ALX04_RS03950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ALX04_RS03955	COG1187	pseudouridine synthase activity
ALX04_RS03960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ALX04_RS03965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ALX04_RS03975	COG4974	Belongs to the 'phage' integrase family
ALX04_RS03980	COG2996	Protein conserved in bacteria
ALX04_RS03995	COG0205	6-phosphofructokinase activity
ALX04_RS04000	COG0587	DNA-directed DNA polymerase activity
ALX04_RS04010	COG0542	response to heat
ALX04_RS04020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ALX04_RS04025	COG2384	SAM-dependent methyltransferase
ALX04_RS04050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ALX04_RS04050	COG0574	Belongs to the PEP-utilizing enzyme family
ALX04_RS04060	COG1846	Transcriptional regulator
ALX04_RS04080	COG2217	Heavy metal translocating P-type atpase
ALX04_RS04085	COG0148	phosphopyruvate hydratase activity
ALX04_RS04090	COG0477	Major facilitator Superfamily
ALX04_RS04100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALX04_RS04110	COG1349	DNA-binding transcription factor activity
ALX04_RS04120	COG1393	Belongs to the ArsC family
ALX04_RS04165	COG2801	Transposase and inactivated derivatives
ALX04_RS04190	COG0546	phosphoglycolate phosphatase activity
ALX04_RS04220	COG0583	DNA-binding transcription factor activity
ALX04_RS04225	COG0604	alcohol dehydrogenase
ALX04_RS04235	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS04240	COG2197	response regulator
ALX04_RS04245	COG4585	Histidine kinase
ALX04_RS04255	COG1131	(ABC) transporter
ALX04_RS04265	COG0519	Catalyzes the synthesis of GMP from XMP
ALX04_RS04295	COG1131	(ABC) transporter
ALX04_RS04315	COG1131	(ABC) transporter
ALX04_RS04320	COG1725	Transcriptional regulator
ALX04_RS04330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALX04_RS04335	COG0358	DNA primase activity
ALX04_RS04340	COG0751	glycine-tRNA ligase activity
ALX04_RS04345	COG0752	glycyl-tRNA synthetase alpha subunit
ALX04_RS04350	COG1381	Involved in DNA repair and RecF pathway recombination
ALX04_RS04355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ALX04_RS04360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ALX04_RS04365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALX04_RS04370	COG1702	phosphate starvation-inducible protein PhoH
ALX04_RS04375	COG1610	YqeY-like protein
ALX04_RS04380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ALX04_RS04385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ALX04_RS04395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ALX04_RS04405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALX04_RS04415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALX04_RS04420	COG0124	histidyl-tRNA synthetase
ALX04_RS04425	COG3103	Sh3 type 3 domain protein
ALX04_RS04425	COG4991	sh3 domain protein
ALX04_RS04425	COG0860	N-Acetylmuramoyl-L-alanine amidase
ALX04_RS04430	COG3001	Fructosamine kinase
ALX04_RS04435	COG0546	phosphoglycolate phosphatase activity
ALX04_RS04440	COG1490	D-aminoacyl-tRNA deacylase activity
ALX04_RS04445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALX04_RS04455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ALX04_RS04460	COG2264	protein methyltransferase activity
ALX04_RS04465	COG2094	Belongs to the DNA glycosylase MPG family
ALX04_RS04480	COG0481	GTPase activity
ALX04_RS04485	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ALX04_RS04490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALX04_RS04495	COG1696	Membrane protein involved in D-alanine export
ALX04_RS04500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ALX04_RS04510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ALX04_RS04515	COG0484	heat shock protein binding
ALX04_RS04520	COG0443	Heat shock 70 kDa protein
ALX04_RS04525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALX04_RS04530	COG1420	regulation of RNA biosynthetic process
ALX04_RS04535	COG3527	Alpha-acetolactate decarboxylase
ALX04_RS04540	COG0196	riboflavin kinase activity
ALX04_RS04545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ALX04_RS04550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALX04_RS04555	COG0287	Prephenate dehydrogenase
ALX04_RS04560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ALX04_RS04570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALX04_RS04575	COG0738	Major facilitator superfamily
ALX04_RS04580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ALX04_RS04585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ALX04_RS04595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ALX04_RS04600	COG0195	Participates in both transcription termination and antitermination
ALX04_RS04605	COG0779	Required for maturation of 30S ribosomal subunits
ALX04_RS04610	COG2176	DNA-directed DNA polymerase activity
ALX04_RS04615	COG0442	prolyl-tRNA aminoacylation
ALX04_RS04620	COG0750	zinc metalloprotease
ALX04_RS04625	COG4589	Belongs to the CDS family
ALX04_RS04630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALX04_RS04635	COG0233	cytoplasmic translational termination
ALX04_RS04640	COG0528	UMP kinase activity
ALX04_RS04645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ALX04_RS04650	COG0052	Belongs to the universal ribosomal protein uS2 family
ALX04_RS04665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALX04_RS04670	COG2827	Endonuclease containing a URI domain
ALX04_RS04675	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ALX04_RS04680	COG0204	Acyl-transferase
ALX04_RS04685	COG3763	UPF0154 protein
ALX04_RS04690	COG4224	UPF0291 protein
ALX04_RS04695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ALX04_RS04710	COG3425	synthase
ALX04_RS04725	COG0463	Glycosyl transferase, family 2
ALX04_RS04735	COG1316	TRANSCRIPTIONal
ALX04_RS04740	COG1116	anion transmembrane transporter activity
ALX04_RS04750	COG0772	Belongs to the SEDS family
ALX04_RS04980	COG1396	sequence-specific DNA binding
ALX04_RS05045	COG0393	Putative heavy-metal-binding
ALX04_RS05060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALX04_RS05065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALX04_RS05065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ALX04_RS05070	COG5416	Lipopolysaccharide assembly protein A domain
ALX04_RS05075	COG0300	oxidoreductase activity
ALX04_RS05080	COG1234	tRNA 3'-trailer cleavage
ALX04_RS05090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALX04_RS05095	COG1349	DNA-binding transcription factor activity
ALX04_RS05100	COG1105	Belongs to the carbohydrate kinase PfkB family
ALX04_RS05105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS05105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS05105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS05110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ALX04_RS05135	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS05140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALX04_RS05145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ALX04_RS05155	COG0489	protein tyrosine kinase activity
ALX04_RS05165	COG0322	excinuclease ABC activity
ALX04_RS05170	COG1126	abc transporter atp-binding protein
ALX04_RS05175	COG0765	amino acid transport
ALX04_RS05195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALX04_RS05200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALX04_RS05205	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALX04_RS05210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALX04_RS05235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALX04_RS05240	COG0268	Binds directly to 16S ribosomal RNA
ALX04_RS05245	COG1466	dna polymerase III delta subunit
ALX04_RS05250	COG2333	competence protein COMEC
ALX04_RS05250	COG0658	competence protein
ALX04_RS05255	COG2131	deaminase
ALX04_RS05260	COG1596	polysaccharide export
ALX04_RS05260	COG1555	photosystem II stabilization
ALX04_RS05265	COG3480	Lon protease (S16) C-terminal proteolytic domain
ALX04_RS05270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALX04_RS05275	COG0742	ribosomal rna small subunit methyltransferase
ALX04_RS05280	COG4471	UPF0298 protein
ALX04_RS05285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ALX04_RS05290	COG0772	Belongs to the SEDS family
ALX04_RS05310	COG1217	gtp-binding protein TYPA
ALX04_RS05315	COG0483	inositol monophosphate 1-phosphatase activity
ALX04_RS05320	COG4476	Belongs to the UPF0223 family
ALX04_RS05325	COG0039	L-malate dehydrogenase activity
ALX04_RS05350	COG0242	peptide deformylase activity
ALX04_RS05360	COG5503	Protein of unknown function (DUF1447)
ALX04_RS05365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ALX04_RS05370	COG1597	lipid kinase activity
ALX04_RS05380	COG1388	LysM domain
ALX04_RS05380	COG3584	3D domain protein
ALX04_RS05385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALX04_RS05390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALX04_RS05420	COG0569	domain protein
ALX04_RS05425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ALX04_RS05430	COG0482	sulfurtransferase activity
ALX04_RS05440	COG1104	cysteine desulfurase activity
ALX04_RS05445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ALX04_RS05455	COG0494	nUDIX hydrolase
ALX04_RS05460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALX04_RS05470	COG3279	Response regulator of the LytR AlgR family
ALX04_RS05485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALX04_RS05490	COG3599	regulation of cell shape
ALX04_RS05500	COG0762	integral membrane protein
ALX04_RS05505	COG1799	cell septum assembly
ALX04_RS05520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ALX04_RS05525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALX04_RS05530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALX04_RS05535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALX04_RS05540	COG0768	penicillin binding
ALX04_RS05550	COG0275	rRNA processing
ALX04_RS05555	COG2001	Belongs to the MraZ family
ALX04_RS05575	COG1674	ftsk spoiiie
ALX04_RS05580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ALX04_RS05590	COG1114	Component of the transport system for branched-chain amino acids
ALX04_RS05605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALX04_RS05610	COG0628	permease
ALX04_RS05620	COG2706	6-phosphogluconolactonase activity
ALX04_RS05625	COG3142	Participates in the control of copper homeostasis
ALX04_RS05630	COG0564	pseudouridine synthase activity
ALX04_RS05635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ALX04_RS05640	COG2357	RelA SpoT domain protein
ALX04_RS05650	COG1164	Oligoendopeptidase f
ALX04_RS05660	COG4862	establishment of competence for transformation
ALX04_RS05665	COG1393	Belongs to the ArsC family
ALX04_RS05670	COG1234	tRNA 3'-trailer cleavage
ALX04_RS05810	COG1098	S1 RNA binding domain
ALX04_RS05820	COG0586	Pfam SNARE associated Golgi protein
ALX04_RS05830	COG0647	UMP catabolic process
ALX04_RS05835	COG4470	Protein conserved in bacteria
ALX04_RS05840	COG0737	Belongs to the 5'-nucleotidase family
ALX04_RS05855	COG1113	amino acid transport
ALX04_RS05860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALX04_RS05865	COG0827	DNA restriction-modification system
ALX04_RS05895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALX04_RS05905	COG0217	transcriptional regulatory protein
ALX04_RS05920	COG1609	Transcriptional regulator
ALX04_RS05925	COG0006	proline dipeptidase activity
ALX04_RS05930	COG0789	Transcriptional regulator
ALX04_RS05945	COG0668	transmembrane transport
ALX04_RS05950	COG1473	amidohydrolase
ALX04_RS05955	COG2171	N-acyltransferase activity
ALX04_RS05960	COG0517	IMP dehydrogenase activity
ALX04_RS05970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALX04_RS05975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ALX04_RS05980	COG1719	4-vinyl reductase, 4VR
ALX04_RS05985	COG3118	belongs to the thioredoxin family
ALX04_RS05990	COG1193	negative regulation of DNA recombination
ALX04_RS06000	COG3906	Belongs to the UPF0473 family
ALX04_RS06005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALX04_RS06010	COG4472	Bacterial protein of unknown function (DUF965)
ALX04_RS06015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ALX04_RS06020	COG0513	Belongs to the DEAD box helicase family
ALX04_RS06025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALX04_RS06030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALX04_RS06035	COG1862	Preprotein translocase
ALX04_RS06040	COG0343	queuine tRNA-ribosyltransferase activity
ALX04_RS06045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALX04_RS06050	COG2255	four-way junction helicase activity
ALX04_RS06055	COG0632	four-way junction helicase activity
ALX04_RS06085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ALX04_RS06090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALX04_RS06095	COG1692	metallophosphoesterase
ALX04_RS06100	COG1418	mRNA catabolic process
ALX04_RS06105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALX04_RS06110	COG1546	Belongs to the CinA family
ALX04_RS06110	COG1058	Belongs to the CinA family
ALX04_RS06115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ALX04_RS06120	COG1426	Protein conserved in bacteria
ALX04_RS06125	COG0612	Peptidase, M16
ALX04_RS06130	COG0612	Peptidase, M16
ALX04_RS06135	COG0527	aspartate kinase activity
ALX04_RS06150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALX04_RS06155	COG1126	abc transporter atp-binding protein
ALX04_RS06160	COG0765	amino acid transport
ALX04_RS06165	COG2894	cell division
ALX04_RS06170	COG0850	regulation of cytokinetic process
ALX04_RS06180	COG1792	Involved in formation and maintenance of cell shape
ALX04_RS06185	COG1077	Cell shape determining protein MreB Mrl
ALX04_RS06190	COG2003	Belongs to the UPF0758 family
ALX04_RS06195	COG0285	dihydrofolate synthase activity
ALX04_RS06200	COG0525	valine-tRNA ligase activity
ALX04_RS06210	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALX04_RS06210	COG2918	glutathione biosynthetic process
ALX04_RS06215	COG0301	tRNA thio-modification
ALX04_RS06220	COG1104	cysteine desulfurase activity
ALX04_RS06230	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ALX04_RS06235	COG1956	GAF domain-containing protein
ALX04_RS06240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALX04_RS06245	COG4493	Belongs to the UPF0637 family
ALX04_RS06260	COG0640	Transcriptional regulator
ALX04_RS06265	COG0366	Alpha amylase catalytic
ALX04_RS06275	COG3716	PTS system mannose fructose sorbose family IID component
ALX04_RS06280	COG3715	PTS system
ALX04_RS06285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS06290	COG1609	Transcriptional regulator
ALX04_RS06295	COG0189	ligase activity
ALX04_RS06295	COG2918	glutathione biosynthetic process
ALX04_RS06300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALX04_RS06315	COG0589	response to stress
ALX04_RS06335	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALX04_RS06355	COG1464	Belongs to the NlpA lipoprotein family
ALX04_RS06360	COG2011	ABC-type metal ion transport system permease component
ALX04_RS06365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ALX04_RS06370	COG0509	glycine decarboxylation via glycine cleavage system
ALX04_RS06375	COG0772	Belongs to the SEDS family
ALX04_RS06385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ALX04_RS06390	COG1077	Cell shape determining protein MreB Mrl
ALX04_RS06400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALX04_RS06405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ALX04_RS06410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALX04_RS06415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ALX04_RS06420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALX04_RS06425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALX04_RS06430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALX04_RS06435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALX04_RS06440	COG0356	it plays a direct role in the translocation of protons across the membrane
ALX04_RS06445	COG2233	PERMEase
ALX04_RS06455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ALX04_RS06460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALX04_RS06465	COG0009	L-threonylcarbamoyladenylate synthase
ALX04_RS06470	COG2890	protein-(glutamine-N5) methyltransferase activity
ALX04_RS06475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALX04_RS06480	COG1435	thymidine kinase activity
ALX04_RS06485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALX04_RS06490	COG3442	glutamine amidotransferase
ALX04_RS06495	COG1482	cell wall glycoprotein biosynthetic process
ALX04_RS06500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ALX04_RS06510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALX04_RS06525	COG1132	(ABC) transporter
ALX04_RS06625	COG3953	SLT domain
ALX04_RS06625	COG5280	Phage tail tape measure protein TP901
ALX04_RS06800	COG1396	sequence-specific DNA binding
ALX04_RS06905	COG4695	Portal protein
ALX04_RS06975	COG4974	Belongs to the 'phage' integrase family
ALX04_RS07000	COG4932	domain protein
ALX04_RS07000	COG4886	Leucine-rich repeat (LRR) protein
ALX04_RS07055	COG1132	(ABC) transporter
ALX04_RS07065	COG1136	(ABC) transporter
ALX04_RS07065	COG0577	efflux transmembrane transporter activity
ALX04_RS07075	COG0166	Belongs to the GPI family
ALX04_RS07080	COG4975	Glucose uptake
ALX04_RS07085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALX04_RS07090	COG3850	Histidine kinase
ALX04_RS07090	COG5002	protein histidine kinase activity
ALX04_RS07095	COG0745	RESPONSE REGULATOR receiver
ALX04_RS07100	COG2848	UPF0210 protein
ALX04_RS07105	COG3830	Belongs to the UPF0237 family
ALX04_RS07130	COG0477	Major facilitator Superfamily
ALX04_RS07150	COG0791	NLP P60 protein
ALX04_RS07155	COG1522	sequence-specific DNA binding
ALX04_RS07175	COG0488	(ABC) transporter
ALX04_RS07200	COG1263	PTS System
ALX04_RS07200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS07200	COG2190	(PTS) system
ALX04_RS07205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ALX04_RS07210	COG1307	EDD domain protein, DegV family
ALX04_RS07220	COG2873	o-acetylhomoserine
ALX04_RS07225	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ALX04_RS07240	COG4120	Belongs to the binding-protein-dependent transport system permease family
ALX04_RS07250	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS07255	COG2084	Dehydrogenase
ALX04_RS07260	COG0861	Integral membrane protein TerC family
ALX04_RS07265	COG0110	maltose O-acetyltransferase activity
ALX04_RS07270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALX04_RS07275	COG0140	phosphoribosyl-ATP diphosphatase activity
ALX04_RS07280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALX04_RS07285	COG0107	imidazoleglycerol-phosphate synthase activity
ALX04_RS07290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALX04_RS07295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ALX04_RS07300	COG0131	Imidazoleglycerol-phosphate dehydratase
ALX04_RS07305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALX04_RS07310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALX04_RS07315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ALX04_RS07320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ALX04_RS07340	COG0789	Transcriptional regulator
ALX04_RS07345	COG0300	oxidoreductase activity
ALX04_RS07355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALX04_RS07370	COG3548	integral membrane protein
ALX04_RS07390	COG1368	sulfuric ester hydrolase activity
ALX04_RS07395	COG0584	glycerophosphoryl diester phosphodiesterase
ALX04_RS07405	COG0492	ferredoxin-NADP+ reductase activity
ALX04_RS07420	COG2326	polyphosphate kinase activity
ALX04_RS07425	COG0778	Nitroreductase
ALX04_RS07435	COG0328	RNA-DNA hybrid ribonuclease activity
ALX04_RS07445	COG1609	Transcriptional regulator
ALX04_RS07455	COG0673	inositol 2-dehydrogenase activity
ALX04_RS07460	COG0673	inositol 2-dehydrogenase activity
ALX04_RS07465	COG0025	NhaP-type Na H and K H
ALX04_RS07470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALX04_RS07480	COG1335	isochorismatase
ALX04_RS07490	COG1131	(ABC) transporter
ALX04_RS07495	COG1725	Transcriptional regulator
ALX04_RS07550	COG0028	Belongs to the TPP enzyme family
ALX04_RS07560	COG1073	alpha beta
ALX04_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALX04_RS07570	COG0626	cystathionine gamma-synthase activity
ALX04_RS07600	COG0095	Lipoate-protein ligase
ALX04_RS07605	COG1705	Flagellar rod assembly protein muramidase FlgJ
ALX04_RS07610	COG0589	response to stress
ALX04_RS07615	COG0564	pseudouridine synthase activity
ALX04_RS07630	COG4640	response to antibiotic
ALX04_RS07635	COG1396	sequence-specific DNA binding
ALX04_RS07650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ALX04_RS07660	COG2188	Transcriptional regulator
ALX04_RS07665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ALX04_RS07675	COG1418	mRNA catabolic process
ALX04_RS07705	COG1253	flavin adenine dinucleotide binding
ALX04_RS07710	COG1780	Probably involved in ribonucleotide reductase function
ALX04_RS07715	COG0025	NhaP-type Na H and K H
ALX04_RS07720	COG2814	Major facilitator Superfamily
ALX04_RS07725	COG0789	Transcriptional regulator
ALX04_RS07730	COG0604	alcohol dehydrogenase
ALX04_RS07740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ALX04_RS07750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALX04_RS07755	COG0436	Aminotransferase
ALX04_RS07760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALX04_RS07775	COG0583	DNA-binding transcription factor activity
ALX04_RS07780	COG0702	epimerase
ALX04_RS07790	COG1074	ATP-dependent DNA helicase activity
ALX04_RS07795	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ALX04_RS07805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ALX04_RS07810	COG0284	orotidine-5'-phosphate decarboxylase activity
ALX04_RS07815	COG0167	dihydroorotate dehydrogenase activity
ALX04_RS07820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALX04_RS07825	COG0505	Belongs to the CarA family
ALX04_RS07830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALX04_RS07835	COG0540	Belongs to the ATCase OTCase family
ALX04_RS07840	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ALX04_RS07845	COG2508	Transcriptional regulator
ALX04_RS07850	COG2233	PERMEase
ALX04_RS07855	COG2252	PERMEase
ALX04_RS07875	COG1215	transferase activity, transferring glycosyl groups
ALX04_RS07885	COG0151	Belongs to the GarS family
ALX04_RS07890	COG0138	bifunctional purine biosynthesis protein purh
ALX04_RS07895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALX04_RS07900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ALX04_RS07910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALX04_RS07915	COG0047	phosphoribosylformylglycinamidine synthase activity
ALX04_RS07920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALX04_RS07925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALX04_RS07930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ALX04_RS07940	COG3976	FMN-binding domain protein
ALX04_RS07940	COG1053	succinate dehydrogenase
ALX04_RS07940	COG0431	NADPH-dependent FMN reductase
ALX04_RS07945	COG3976	FMN-binding domain protein
ALX04_RS07945	COG0431	NADPH-dependent FMN reductase
ALX04_RS07945	COG1053	succinate dehydrogenase
ALX04_RS07950	COG0095	Lipoate-protein ligase
ALX04_RS07955	COG2365	Tyrosine phosphatase family
ALX04_RS07975	COG1136	(ABC) transporter
ALX04_RS07990	COG1725	Transcriptional regulator
ALX04_RS07995	COG1131	(ABC) transporter
ALX04_RS08005	COG0589	response to stress
ALX04_RS08015	COG2246	polysaccharide biosynthetic process
ALX04_RS08035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ALX04_RS08060	COG0366	Alpha amylase catalytic
ALX04_RS08070	COG0561	phosphatase activity
ALX04_RS08080	COG0110	maltose O-acetyltransferase activity
ALX04_RS08085	COG0494	nUDIX hydrolase
ALX04_RS08120	COG1827	regulation of RNA biosynthetic process
ALX04_RS08125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ALX04_RS08130	COG1309	transcriptional regulator
ALX04_RS08140	COG1131	(ABC) transporter
ALX04_RS08145	COG3048	D-serine ammonia-lyase activity
ALX04_RS08150	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS08155	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS08160	COG1447	Phosphotransferase system cellobiose-specific component IIA
ALX04_RS08165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS08170	COG2188	Transcriptional regulator
ALX04_RS08175	COG1216	Glycosyl transferase, family 2
ALX04_RS08190	COG0561	phosphatase activity
ALX04_RS08195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ALX04_RS08220	COG0716	FMN binding
ALX04_RS08240	COG0710	3-dehydroquinate dehydratase activity
ALX04_RS08245	COG0531	amino acid
ALX04_RS08290	COG4720	Psort location CytoplasmicMembrane, score
ALX04_RS08295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALX04_RS08310	COG4990	cell redox homeostasis
ALX04_RS08335	COG1811	Na channel or pump
ALX04_RS08355	COG0577	efflux transmembrane transporter activity
ALX04_RS08360	COG1136	(ABC) transporter
ALX04_RS08400	COG2814	Major facilitator Superfamily
ALX04_RS08410	COG2814	Major facilitator Superfamily
ALX04_RS08420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ALX04_RS08425	COG2855	membrane
ALX04_RS08430	COG0583	DNA-binding transcription factor activity
ALX04_RS08440	COG0438	transferase activity, transferring glycosyl groups
ALX04_RS08455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALX04_RS08475	COG4152	abc transporter atp-binding protein
ALX04_RS08485	COG4221	oxidoreductase activity
ALX04_RS08500	COG0789	Transcriptional regulator
ALX04_RS08520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALX04_RS08545	COG0456	acetyltransferase
ALX04_RS08580	COG0583	DNA-binding transcription factor activity
ALX04_RS08590	COG1063	alcohol dehydrogenase
ALX04_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS08600	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS08620	COG4975	Glucose uptake
ALX04_RS08630	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS08635	COG0583	DNA-binding transcription factor activity
ALX04_RS08655	COG4221	oxidoreductase activity
ALX04_RS08660	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS08665	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS08685	COG1396	sequence-specific DNA binding
ALX04_RS08695	COG0589	response to stress
ALX04_RS08700	COG0110	maltose O-acetyltransferase activity
ALX04_RS08705	COG1011	Hydrolase
ALX04_RS08720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ALX04_RS08730	COG0667	Aldo Keto reductase
ALX04_RS08735	COG1132	(ABC) transporter
ALX04_RS08740	COG1132	(ABC) transporter
ALX04_RS08745	COG2814	Major facilitator Superfamily
ALX04_RS08760	COG1511	domain protein
ALX04_RS08760	COG1511	domain protein
ALX04_RS08770	COG0640	Transcriptional regulator
ALX04_RS08805	COG0488	(ABC) transporter
ALX04_RS08820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALX04_RS08835	COG2267	carboxylic ester hydrolase activity
ALX04_RS08840	COG0531	amino acid
ALX04_RS08845	COG2270	Major facilitator Superfamily
ALX04_RS08885	COG2200	EAL domain
ALX04_RS08895	COG1328	CTP reductase activity
ALX04_RS08905	COG0242	peptide deformylase activity
ALX04_RS08915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALX04_RS08935	COG0583	DNA-binding transcription factor activity
ALX04_RS08945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ALX04_RS09030	COG1940	carbohydrate kinase activity
ALX04_RS09035	COG1132	(ABC) transporter
ALX04_RS09045	COG0778	Nitroreductase
ALX04_RS09050	COG1263	PTS System
ALX04_RS09050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS09050	COG2190	(PTS) system
ALX04_RS09055	COG1116	anion transmembrane transporter activity
ALX04_RS09060	COG4120	Belongs to the binding-protein-dependent transport system permease family
ALX04_RS09090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ALX04_RS09090	COG0617	tRNA 3'-terminal CCA addition
ALX04_RS09090	COG3620	sequence-specific DNA binding
ALX04_RS09095	COG0410	ABC transporter
ALX04_RS09110	COG0559	Belongs to the binding-protein-dependent transport system permease family
ALX04_RS09125	COG5549	protein import
ALX04_RS09125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALX04_RS09130	COG2246	polysaccharide biosynthetic process
ALX04_RS09140	COG1914	H( )-stimulated, divalent metal cation uptake system
ALX04_RS09160	COG0640	Transcriptional regulator
ALX04_RS09180	COG1136	(ABC) transporter
ALX04_RS09180	COG0577	efflux transmembrane transporter activity
ALX04_RS09220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS09225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS09230	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS09240	COG0789	Transcriptional regulator
ALX04_RS09245	COG0741	lytic transglycosylase activity
ALX04_RS09265	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALX04_RS09290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALX04_RS09305	COG4221	oxidoreductase activity
ALX04_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS09350	COG1132	(ABC) transporter
ALX04_RS09355	COG1132	(ABC) transporter
ALX04_RS09365	COG1473	amidohydrolase
ALX04_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS09385	COG0531	amino acid
ALX04_RS09415	COG2217	Heavy metal translocating P-type atpase
ALX04_RS09475	COG1063	alcohol dehydrogenase
ALX04_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALX04_RS09520	COG1733	regulation of RNA biosynthetic process
ALX04_RS09525	COG2814	Major facilitator Superfamily
ALX04_RS09535	COG0367	asparagine synthase
ALX04_RS09540	COG3279	Response regulator of the LytR AlgR family
ALX04_RS09555	COG1309	transcriptional regulator
ALX04_RS09565	COG1012	belongs to the aldehyde dehydrogenase family
ALX04_RS09585	COG1733	regulation of RNA biosynthetic process
ALX04_RS09590	COG0300	oxidoreductase activity
ALX04_RS09725	COG2801	Transposase and inactivated derivatives
ALX04_RS09750	COG1511	domain protein
ALX04_RS09760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALX04_RS09770	COG2226	methyltransferase
ALX04_RS09775	COG0588	phosphoglycerate mutase activity
ALX04_RS09780	COG0628	permease
ALX04_RS09785	COG1940	carbohydrate kinase activity
ALX04_RS09785	COG1846	Transcriptional regulator
ALX04_RS09795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALX04_RS09805	COG2815	serine threonine protein kinase
ALX04_RS09805	COG0515	serine threonine protein kinase
ALX04_RS09845	COG1247	-acetyltransferase
ALX04_RS09850	COG1686	Belongs to the peptidase S11 family
ALX04_RS09870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALX04_RS09875	COG0517	IMP dehydrogenase activity
ALX04_RS09875	COG0516	GMP reductase activity
ALX04_RS09885	COG0012	GTP binding
ALX04_RS09890	COG4481	Protein conserved in bacteria
ALX04_RS09895	COG1475	DNA binding
ALX04_RS09900	COG1192	Involved in chromosome partitioning
ALX04_RS09910	COG0357	Ribosomal RNA small subunit methyltransferase G
ALX04_RS09915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ALX04_RS09930	COG0583	DNA-binding transcription factor activity
ALX04_RS09935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALX04_RS09940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALX04_RS09945	COG0765	amino acid transport
ALX04_RS09950	COG1126	abc transporter atp-binding protein
ALX04_RS09955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALX04_RS09980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS09980	COG1263	PTS System
ALX04_RS09980	COG2190	(PTS) system
ALX04_RS09985	COG0366	Alpha amylase catalytic
ALX04_RS09990	COG1609	Transcriptional regulator
ALX04_RS10005	COG0390	transport system, permease component
ALX04_RS10010	COG4619	ABC transporter
ALX04_RS10015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALX04_RS10030	COG0561	phosphatase activity
ALX04_RS10040	COG0383	alpha-mannosidase activity
ALX04_RS10045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS10045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS10045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS10050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS10055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS10055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALX04_RS10055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS10060	COG3711	transcriptional antiterminator
ALX04_RS10060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS10105	COG0735	belongs to the Fur family
ALX04_RS10130	COG1380	Effector of murein hydrolase LrgA
ALX04_RS10140	COG1307	EDD domain protein, DegV family
ALX04_RS10150	COG2738	Putative neutral zinc metallopeptidase
ALX04_RS10155	COG1233	COG1233 Phytoene dehydrogenase and related
ALX04_RS10160	COG1562	ergosterol biosynthetic process
ALX04_RS10170	COG1929	Belongs to the glycerate kinase type-1 family
ALX04_RS10185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ALX04_RS10190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ALX04_RS10195	COG0516	GMP reductase activity
ALX04_RS10200	COG2365	Tyrosine phosphatase family
ALX04_RS10205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALX04_RS10215	COG1511	domain protein
ALX04_RS10235	COG0531	amino acid
ALX04_RS10240	COG3158	transport of potassium into the cell
ALX04_RS10245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ALX04_RS10250	COG0628	permease
ALX04_RS10255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ALX04_RS10270	COG1272	protein, Hemolysin III
ALX04_RS10275	COG0640	Transcriptional regulator
ALX04_RS10310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALX04_RS10320	COG0302	gtp cyclohydrolase
ALX04_RS10325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ALX04_RS10345	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALX04_RS10350	COG2814	Major facilitator Superfamily
ALX04_RS10380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ALX04_RS10385	COG1882	Formate acetyltransferase
ALX04_RS10390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ALX04_RS10400	COG2151	metal-sulfur cluster biosynthetic enzyme
ALX04_RS10405	COG4989	oxidoreductase activity
ALX04_RS10440	COG2217	Heavy metal translocating P-type atpase
ALX04_RS10450	COG2315	Protein conserved in bacteria
ALX04_RS10460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ALX04_RS10465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALX04_RS10475	COG1757	Na H antiporter
ALX04_RS10480	COG1113	amino acid transport
ALX04_RS10490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ALX04_RS10505	COG1393	Belongs to the ArsC family
ALX04_RS10510	COG3189	MarR family transcriptional regulator
ALX04_RS10520	COG1194	a g-specific adenine glycosylase
ALX04_RS10535	COG0071	Belongs to the small heat shock protein (HSP20) family
ALX04_RS10560	COG0697	spore germination
ALX04_RS10575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ALX04_RS10600	COG0477	Major facilitator Superfamily
ALX04_RS10660	COG0737	Belongs to the 5'-nucleotidase family
ALX04_RS10670	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS10690	COG1968	undecaprenyl-diphosphatase activity
ALX04_RS10695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ALX04_RS10730	COG2207	Transcriptional regulator
ALX04_RS10755	COG0076	glutamate decarboxylase activity
ALX04_RS10800	COG1309	transcriptional regulator
ALX04_RS10810	COG2226	methyltransferase
ALX04_RS10825	COG2217	Heavy metal translocating P-type atpase
ALX04_RS10830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS10835	COG3118	belongs to the thioredoxin family
ALX04_RS10840	COG1937	Protein conserved in bacteria
ALX04_RS10860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALX04_RS10865	COG3590	peptidase
ALX04_RS10885	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS10935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS10945	COG1114	Component of the transport system for branched-chain amino acids
ALX04_RS10955	COG1874	Beta-galactosidase
ALX04_RS10960	COG1609	Transcriptional regulator
ALX04_RS10970	COG0477	Major facilitator Superfamily
ALX04_RS10990	COG2184	nucleotidyltransferase activity
ALX04_RS10995	COG2944	sequence-specific DNA binding
ALX04_RS11000	COG1609	Transcriptional regulator
ALX04_RS11005	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ALX04_RS11010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALX04_RS11015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ALX04_RS11035	COG2190	(PTS) system
ALX04_RS11035	COG2211	Major facilitator Superfamily
ALX04_RS11040	COG2017	converts alpha-aldose to the beta-anomer
ALX04_RS11045	COG1609	Transcriptional regulator
ALX04_RS11050	COG0667	Aldo Keto reductase
ALX04_RS11070	COG0710	3-dehydroquinate dehydratase activity
ALX04_RS11075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALX04_RS11080	COG0583	DNA-binding transcription factor activity
ALX04_RS11085	COG2271	Major facilitator Superfamily
ALX04_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS11115	COG2271	Major facilitator Superfamily
ALX04_RS11125	COG2267	carboxylic ester hydrolase activity
ALX04_RS11130	COG2188	Transcriptional regulator
ALX04_RS11135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS11140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ALX04_RS11145	COG2971	BadF BadG BcrA BcrD
ALX04_RS11155	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS11165	COG3711	transcriptional antiterminator
ALX04_RS11170	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS11175	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS11180	COG1263	PTS System
ALX04_RS11180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS11180	COG2190	(PTS) system
ALX04_RS11200	COG2211	Major facilitator Superfamily
ALX04_RS11215	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ALX04_RS11230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALX04_RS11250	COG3711	transcriptional antiterminator
ALX04_RS11265	COG3775	system Galactitol-specific IIC component
ALX04_RS11270	COG3414	Phosphotransferase system galactitol-specific IIB component
ALX04_RS11280	COG1349	DNA-binding transcription factor activity
ALX04_RS11285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ALX04_RS11295	COG0110	maltose O-acetyltransferase activity
ALX04_RS11300	COG2160	L-arabinose isomerase activity
ALX04_RS11320	COG1609	Transcriptional regulator
ALX04_RS11325	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ALX04_RS11355	COG2261	transglycosylase associated protein
ALX04_RS11365	COG1393	Belongs to the ArsC family
ALX04_RS11385	COG4512	PFAM Accessory gene regulator B
ALX04_RS11400	COG1304	FMN binding
ALX04_RS11405	COG0028	Belongs to the TPP enzyme family
ALX04_RS11410	COG1959	2 iron, 2 sulfur cluster binding
ALX04_RS11415	COG0028	Belongs to the TPP enzyme family
ALX04_RS11425	COG3732	PTS system glucitol sorbitol-specific
ALX04_RS11430	COG3730	PTS system glucitol sorbitol-specific
ALX04_RS11450	COG4975	Glucose uptake
ALX04_RS11455	COG1869	D-ribose catabolic process
ALX04_RS11465	COG1609	Transcriptional regulator
ALX04_RS11470	COG1454	alcohol dehydrogenase
ALX04_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
ALX04_RS11480	COG1695	Transcriptional regulator
ALX04_RS11485	COG3479	Phenolic acid decarboxylase
ALX04_RS11500	COG1307	EDD domain protein, DegV family
ALX04_RS11540	COG0445	tRNA wobble uridine modification
ALX04_RS11545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALX04_RS11550	COG1847	R3H domain protein
ALX04_RS11555	COG0706	membrane insertase activity
ALX04_RS11560	COG0594	ribonuclease P activity
ALX04_RS11565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ALX04_RS11570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALX04_RS11575	COG0592	DNA-directed DNA polymerase activity
ALX04_RS11580	COG2501	S4 domain
ALX04_RS11585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALX04_RS11590	COG0187	DNA topoisomerase II activity
ALX04_RS11600	COG0360	Binds together with S18 to 16S ribosomal RNA
ALX04_RS11605	COG0629	single-stranded DNA binding
ALX04_RS11610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALX04_RS11620	COG0359	binds to the 23S rRNA
ALX04_RS11625	COG0305	Participates in initiation and elongation during chromosome replication
ALX04_RS11630	COG2814	Major facilitator Superfamily
ALX04_RS11635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ALX04_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALX04_RS11645	COG4166	transmembrane transport
ALX04_RS11655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ALX04_RS11660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ALX04_RS11665	COG0297	glycogen (starch) synthase activity
ALX04_RS11670	COG0058	SHG alpha-glucan phosphorylase activity
ALX04_RS11685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALX04_RS11690	COG1554	hydrolase, family 65, central catalytic
ALX04_RS11700	COG1278	Cold shock
ALX04_RS11715	COG0745	RESPONSE REGULATOR receiver
ALX04_RS11720	COG5002	protein histidine kinase activity
ALX04_RS11730	COG4853	Protein conserved in bacteria
ALX04_RS11735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALX04_RS11740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALX04_RS11745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALX04_RS11755	COG1012	belongs to the aldehyde dehydrogenase family
ALX04_RS11765	COG1573	uracil-dna glycosylase
ALX04_RS11785	COG3976	FMN-binding domain protein
ALX04_RS11785	COG1053	succinate dehydrogenase
ALX04_RS11785	COG0431	NADPH-dependent FMN reductase
ALX04_RS11790	COG0471	metal ion transport
ALX04_RS11805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALX04_RS11810	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS11820	COG0778	Nitroreductase
ALX04_RS11825	COG2508	Transcriptional regulator
ALX04_RS11835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALX04_RS11840	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ALX04_RS11850	COG2365	Tyrosine phosphatase family
ALX04_RS11855	COG2368	4-hydroxyphenylacetate
ALX04_RS11875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ALX04_RS11910	COG0604	alcohol dehydrogenase
ALX04_RS11940	COG2267	carboxylic ester hydrolase activity
ALX04_RS11945	COG3022	response to hydroperoxide
ALX04_RS11955	COG4166	transmembrane transport
ALX04_RS11980	COG1122	ATPase activity
ALX04_RS11985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ALX04_RS11990	COG0310	cobalt ion transport
ALX04_RS11995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALX04_RS12000	COG3875	lactate racemase activity
ALX04_RS12005	COG1691	(AIR) carboxylase
ALX04_RS12010	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ALX04_RS12015	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ALX04_RS12020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS12025	COG1606	tRNA processing
ALX04_RS12030	COG0604	alcohol dehydrogenase
ALX04_RS12035	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ALX04_RS12040	COG0351	phosphomethylpyrimidine kinase
ALX04_RS12045	COG0352	thiamine-phosphate diphosphorylase activity
ALX04_RS12055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ALX04_RS12070	COG1113	amino acid transport
ALX04_RS12085	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
ALX04_RS12090	COG1518	maintenance of DNA repeat elements
ALX04_RS12105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALX04_RS12115	COG1983	PspC domain protein
ALX04_RS12155	COG2807	transmembrane transport
ALX04_RS12160	COG0656	L-ascorbic acid biosynthetic process
ALX04_RS12165	COG0667	Aldo Keto reductase
ALX04_RS12195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ALX04_RS12200	COG1122	ATPase activity
ALX04_RS12205	COG4720	Psort location CytoplasmicMembrane, score
ALX04_RS12215	COG2188	Transcriptional regulator
ALX04_RS12240	COG1028	Short-chain dehydrogenase reductase Sdr
ALX04_RS12245	COG1131	(ABC) transporter
ALX04_RS12260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ALX04_RS12265	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ALX04_RS12270	COG1309	transcriptional regulator
ALX04_RS12275	COG2376	Dihydroxyacetone kinase
ALX04_RS12280	COG2376	Dihydroxyacetone kinase
ALX04_RS12285	COG1461	Dihydroxyacetone kinase
ALX04_RS12290	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ALX04_RS12295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS12300	COG1609	Transcriptional regulator
ALX04_RS12305	COG1609	Transcriptional regulator
ALX04_RS12310	COG0366	Alpha amylase catalytic
ALX04_RS12315	COG2182	Extracellular solute-binding protein
ALX04_RS12320	COG1175	transmembrane transport
ALX04_RS12325	COG3833	ABC-type maltose transport systems, permease component
ALX04_RS12335	COG0366	Alpha amylase catalytic
ALX04_RS12340	COG3842	ATPase activity
ALX04_RS12395	COG1757	Na H antiporter
ALX04_RS12425	COG4166	transmembrane transport
ALX04_RS12435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALX04_RS12440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALX04_RS12445	COG0406	alpha-ribazole phosphatase activity
ALX04_RS12450	COG0667	Aldo Keto reductase
ALX04_RS12480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALX04_RS12485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALX04_RS12490	COG0488	(ABC) transporter
ALX04_RS12500	COG4172	Belongs to the ABC transporter superfamily
ALX04_RS12510	COG0386	Belongs to the glutathione peroxidase family
ALX04_RS12520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALX04_RS12535	COG0363	glucosamine-6-phosphate deaminase activity
ALX04_RS12545	COG3976	FMN-binding domain protein
ALX04_RS12545	COG1053	succinate dehydrogenase
ALX04_RS12560	COG2213	PTS system mannitol-specific
ALX04_RS12570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS12575	COG0246	Mannitol dehydrogenase
ALX04_RS12585	COG3118	belongs to the thioredoxin family
ALX04_RS12615	COG0431	NADPH-dependent FMN reductase
ALX04_RS12620	COG2188	Transcriptional regulator
ALX04_RS12625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS12640	COG3964	amidohydrolase
ALX04_RS12660	COG1045	serine acetyltransferase
ALX04_RS12665	COG0626	cystathionine gamma-synthase activity
ALX04_RS12670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ALX04_RS12700	COG2188	Transcriptional regulator
ALX04_RS12705	COG0366	Alpha amylase catalytic
ALX04_RS12710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS12710	COG1263	PTS System
ALX04_RS12710	COG2190	(PTS) system
ALX04_RS12715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS12715	COG2190	(PTS) system
ALX04_RS12715	COG1263	PTS System
ALX04_RS12725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALX04_RS12730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALX04_RS12735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALX04_RS12750	COG0163	prenyltransferase activity
ALX04_RS12760	COG1959	2 iron, 2 sulfur cluster binding
ALX04_RS12765	COG1309	transcriptional regulator
ALX04_RS12770	COG1914	H( )-stimulated, divalent metal cation uptake system
ALX04_RS12790	COG2814	Major facilitator Superfamily
ALX04_RS12800	COG5002	protein histidine kinase activity
ALX04_RS12805	COG0745	RESPONSE REGULATOR receiver
ALX04_RS12815	COG1737	Transcriptional regulator
ALX04_RS12820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS12835	COG1316	TRANSCRIPTIONal
ALX04_RS12840	COG0277	FAD linked oxidase domain protein
ALX04_RS12850	COG2357	RelA SpoT domain protein
ALX04_RS12860	COG2409	Drug exporters of the RND superfamily
ALX04_RS12860	COG1033	growth of symbiont in host cell
ALX04_RS12865	COG2818	Glycosylase
ALX04_RS12875	COG0577	efflux transmembrane transporter activity
ALX04_RS12880	COG1136	(ABC) transporter
ALX04_RS12895	COG0741	lytic transglycosylase activity
ALX04_RS12900	COG1388	LysM domain
ALX04_RS12900	COG3942	CHAP domain
ALX04_RS12930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALX04_RS12940	COG1846	Transcriptional regulator
ALX04_RS12945	COG1252	NADH dehydrogenase
ALX04_RS12970	COG3842	ATPase activity
ALX04_RS13000	COG1725	Transcriptional regulator
ALX04_RS13005	COG1131	(ABC) transporter
ALX04_RS13015	COG1012	belongs to the aldehyde dehydrogenase family
ALX04_RS13015	COG1454	alcohol dehydrogenase
ALX04_RS13050	COG1268	BioY protein
ALX04_RS13065	COG0436	Aminotransferase
ALX04_RS13075	COG1682	transport, permease protein
ALX04_RS13080	COG1134	teichoic acid transport
ALX04_RS13095	COG2814	Major facilitator Superfamily
ALX04_RS13100	COG0004	ammonium transporteR
ALX04_RS13120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ALX04_RS13130	COG3759	membrane
ALX04_RS13135	COG1881	PFAM PEBP family protein
ALX04_RS13165	COG0300	oxidoreductase activity
ALX04_RS13185	COG1125	glycine betaine transport
ALX04_RS13195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALX04_RS13205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ALX04_RS13305	COG0110	maltose O-acetyltransferase activity
ALX04_RS13315	COG0561	phosphatase activity
ALX04_RS13325	COG0561	phosphatase activity
ALX04_RS13330	COG1114	Component of the transport system for branched-chain amino acids
ALX04_RS13370	COG3290	protein histidine kinase activity
ALX04_RS13395	COG2274	protein secretion by the type I secretion system
ALX04_RS13430	COG3973	AAA domain
ALX04_RS13435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALX04_RS13440	COG0180	Tryptophanyl-tRNA synthetase
ALX04_RS13445	COG2188	Transcriptional regulator
ALX04_RS13450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS13465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ALX04_RS13470	COG2723	6-phospho-beta-galactosidase activity
ALX04_RS13475	COG1940	carbohydrate kinase activity
ALX04_RS13485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALX04_RS13490	COG0248	Ppx GppA phosphatase
ALX04_RS13505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ALX04_RS13510	COG1801	Protein of unknown function DUF72
ALX04_RS13520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALX04_RS13520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALX04_RS13525	COG2814	Major facilitator Superfamily
ALX04_RS13530	COG0084	hydrolase, TatD family'
ALX04_RS13535	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ALX04_RS13540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALX04_RS13545	COG4466	Protein conserved in bacteria
ALX04_RS13550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALX04_RS13555	COG1073	alpha beta
ALX04_RS13560	COG1121	(ABC) transporter
ALX04_RS13565	COG1321	iron dependent repressor
ALX04_RS13565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALX04_RS13570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALX04_RS13575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ALX04_RS13585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALX04_RS13605	COG1078	dGTPase activity
ALX04_RS13610	COG0095	Lipoate-protein ligase
ALX04_RS13620	COG3343	RNA polymerase activity
ALX04_RS13625	COG0504	CTP synthase activity
ALX04_RS13630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALX04_RS13635	COG0814	amino acid
ALX04_RS13645	COG1760	l-serine dehydratase
ALX04_RS13650	COG1760	l-serine dehydratase
ALX04_RS13665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALX04_RS13670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ALX04_RS13675	COG0254	rRNA binding
ALX04_RS13685	COG3764	Sortase (surface protein transpeptidase)
ALX04_RS13690	COG1704	LemA family
ALX04_RS13695	COG0501	Belongs to the peptidase M48B family
ALX04_RS13705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALX04_RS13720	COG0736	holo-[acyl-carrier-protein] synthase activity
ALX04_RS13725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALX04_RS13730	COG2337	Toxic component of a toxin-antitoxin (TA) module
ALX04_RS13735	COG3158	transport of potassium into the cell
ALX04_RS13755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALX04_RS13760	COG0505	Belongs to the CarA family
ALX04_RS13765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ALX04_RS13770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ALX04_RS13775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ALX04_RS13780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALX04_RS13785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALX04_RS13805	COG0039	L-malate dehydrogenase activity
ALX04_RS13810	COG0193	aminoacyl-tRNA hydrolase activity
ALX04_RS13815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALX04_RS13820	COG2244	polysaccharide biosynthetic process
ALX04_RS13825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ALX04_RS13835	COG1098	S1 RNA binding domain
ALX04_RS13840	COG0037	tRNA processing
ALX04_RS13855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ALX04_RS13860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALX04_RS13865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALX04_RS13905	COG3104	oligopeptide transport
ALX04_RS13925	COG0582	viral genome integration into host DNA
ALX04_RS14000	COG0531	amino acid
ALX04_RS14050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ALX04_RS14060	COG2188	Transcriptional regulator
ALX04_RS14070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ALX04_RS14075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALX04_RS14090	COG2183	response to ionizing radiation
ALX04_RS14095	COG3091	SprT-like family
ALX04_RS14100	COG0460	homoserine dehydrogenase
ALX04_RS14105	COG0083	homoserine kinase activity
ALX04_RS14125	COG3715	PTS system
ALX04_RS14130	COG3716	PTS system mannose fructose sorbose family IID component
ALX04_RS14140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ALX04_RS14140	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ALX04_RS14145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS14145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS14150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALX04_RS14150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS14155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALX04_RS14165	COG0439	Biotin carboxylase
ALX04_RS14175	COG0825	malonyl-CoA metabolic process
ALX04_RS14180	COG1316	TRANSCRIPTIONal
ALX04_RS14190	COG0697	spore germination
ALX04_RS14195	COG0588	phosphoglycerate mutase activity
ALX04_RS14210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ALX04_RS14220	COG0756	dUTP diphosphatase activity
ALX04_RS14240	COG4956	integral membrane protein (PIN domain superfamily)
ALX04_RS14245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALX04_RS14250	COG0215	cysteine-tRNA ligase activity
ALX04_RS14255	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ALX04_RS14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALX04_RS14275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALX04_RS14285	COG0250	Participates in transcription elongation, termination and antitermination
ALX04_RS14295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALX04_RS14300	COG0081	regulation of translation
ALX04_RS14305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALX04_RS14310	COG0222	ribosome binding
ALX04_RS14330	COG1611	Belongs to the LOG family
ALX04_RS14340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALX04_RS14345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ALX04_RS14350	COG2813	Specifically methylates the guanine in position
ALX04_RS14365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALX04_RS14370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALX04_RS14375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALX04_RS14385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALX04_RS14390	COG3870	Protein conserved in bacteria
ALX04_RS14395	COG0470	DNA polymerase III
ALX04_RS14400	COG4467	Involved in initiation control of chromosome replication
ALX04_RS14415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALX04_RS14420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ALX04_RS14425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALX04_RS14430	COG3639	organic phosphonate transmembrane transporter activity
ALX04_RS14440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ALX04_RS14450	COG1214	PFAM Peptidase M22, glycoprotease
ALX04_RS14455	COG0456	acetyltransferase
ALX04_RS14460	COG0456	acetyltransferase
ALX04_RS14465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALX04_RS14475	COG0488	(ABC) transporter
ALX04_RS14480	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ALX04_RS14490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ALX04_RS14495	COG0459	protein refolding
ALX04_RS14500	COG0531	amino acid
ALX04_RS14505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALX04_RS14510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ALX04_RS14515	COG1739	Uncharacterized protein family UPF0029
ALX04_RS14520	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ALX04_RS14535	COG0653	protein targeting
ALX04_RS14540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALX04_RS14550	COG0745	RESPONSE REGULATOR receiver
ALX04_RS14555	COG5002	protein histidine kinase activity
ALX04_RS14560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ALX04_RS14565	COG0573	inorganic phosphate transmembrane transporter activity
ALX04_RS14570	COG0581	inorganic phosphate transmembrane transporter activity
ALX04_RS14575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ALX04_RS14580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ALX04_RS14585	COG0704	Plays a role in the regulation of phosphate uptake
ALX04_RS14590	COG1983	PspC domain protein
ALX04_RS14595	COG1950	PFAM Membrane protein of
ALX04_RS14600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ALX04_RS14605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ALX04_RS14610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALX04_RS14615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ALX04_RS14625	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS14630	COG0492	ferredoxin-NADP+ reductase activity
ALX04_RS14635	COG2323	membrane
ALX04_RS14645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALX04_RS14655	COG0446	pyridine nucleotide-disulphide oxidoreductase
ALX04_RS14665	COG2814	Major facilitator Superfamily
ALX04_RS14675	COG0556	nucleotide-excision repair
ALX04_RS14680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALX04_RS14685	COG1854	S-ribosylhomocysteine lyase activity
ALX04_RS14690	COG0137	argininosuccinate synthase activity
ALX04_RS14695	COG0165	Argininosuccinate lyase
ALX04_RS14705	COG1660	Displays ATPase and GTPase activities
ALX04_RS14715	COG1481	regulation of sporulation
ALX04_RS14725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALX04_RS14730	COG0740	serine-type endopeptidase activity
ALX04_RS14740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ALX04_RS14745	COG2390	Transcriptional regulator
ALX04_RS14755	COG0126	phosphoglycerate kinase activity
ALX04_RS14760	COG0149	triose-phosphate isomerase activity
ALX04_RS14765	COG0148	phosphopyruvate hydratase activity
ALX04_RS14780	COG0038	chloride channel
ALX04_RS14785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALX04_RS14795	COG0557	exoribonuclease II activity
ALX04_RS14800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ALX04_RS14810	COG0765	amino acid transport
ALX04_RS14815	COG1126	abc transporter atp-binding protein
ALX04_RS14825	COG0561	phosphatase activity
ALX04_RS14830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALX04_RS14835	COG0280	phosphate acetyltransferase
ALX04_RS14840	COG0802	atpase or kinase
ALX04_RS14855	COG0708	Exodeoxyribonuclease III
ALX04_RS14865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALX04_RS14870	COG0025	NhaP-type Na H and K H
ALX04_RS14895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALX04_RS14900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALX04_RS14910	COG0561	phosphatase activity
ALX04_RS14920	COG2017	converts alpha-aldose to the beta-anomer
ALX04_RS14935	COG0778	Nitroreductase
ALX04_RS14955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALX04_RS14970	COG1393	Belongs to the ArsC family
ALX04_RS14985	COG0477	Major facilitator Superfamily
ALX04_RS14995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALX04_RS15005	COG3475	LICD family
ALX04_RS15020	COG2252	PERMEase
ALX04_RS15025	COG0028	Belongs to the TPP enzyme family
ALX04_RS15030	COG0196	riboflavin kinase activity
ALX04_RS15035	COG0028	Belongs to the TPP enzyme family
ALX04_RS15040	COG2267	carboxylic ester hydrolase activity
ALX04_RS15050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ALX04_RS15050	COG2755	lipolytic protein G-D-S-L family
ALX04_RS15055	COG2936	dipeptidyl-peptidase activity
ALX04_RS15070	COG0531	amino acid
ALX04_RS15095	COG0194	GDP metabolic process
ALX04_RS15100	COG0735	belongs to the Fur family
ALX04_RS15115	COG0546	phosphoglycolate phosphatase activity
ALX04_RS15120	COG0436	Aminotransferase
ALX04_RS15125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALX04_RS15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALX04_RS15150	COG0765	amino acid transport
ALX04_RS15155	COG0765	amino acid transport
ALX04_RS15165	COG2190	(PTS) system
ALX04_RS15165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS15165	COG1263	PTS System
ALX04_RS15175	COG1263	PTS System
ALX04_RS15175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALX04_RS15180	COG3394	polysaccharide catabolic process
ALX04_RS15185	COG0531	amino acid
ALX04_RS15195	COG1846	Transcriptional regulator
ALX04_RS15225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ALX04_RS15235	COG2076	Multidrug Resistance protein
ALX04_RS15250	COG0588	phosphoglycerate mutase activity
ALX04_RS15255	COG0569	domain protein
ALX04_RS15255	COG0475	glutathione-regulated potassium exporter activity
ALX04_RS15260	COG0456	acetyltransferase
ALX04_RS15260	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ALX04_RS15265	COG0586	Pfam SNARE associated Golgi protein
ALX04_RS15270	COG3973	AAA domain
ALX04_RS15275	COG2070	2-Nitropropane dioxygenase
ALX04_RS15280	COG1072	(Pantothenic acid kinase))
ALX04_RS15285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALX04_RS15285	COG0519	Catalyzes the synthesis of GMP from XMP
ALX04_RS15295	COG1396	sequence-specific DNA binding
ALX04_RS15305	COG1266	CAAX protease self-immunity
ALX04_RS15320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ALX04_RS15320	COG2755	lipolytic protein G-D-S-L family
ALX04_RS15325	COG2261	transglycosylase associated protein
ALX04_RS15340	COG1302	Protein conserved in bacteria
ALX04_RS15370	COG0308	aminopeptidase N
ALX04_RS15375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALX04_RS15465	COG3716	PTS system mannose fructose sorbose family IID component
ALX04_RS15485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALX04_RS15490	COG3118	belongs to the thioredoxin family
ALX04_RS15495	COG0492	ferredoxin-NADP+ reductase activity
ALX04_RS15505	COG3118	belongs to the thioredoxin family
ALX04_RS15525	COG1846	Transcriptional regulator
ALX04_RS15570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ALX04_RS15585	COG1192	Involved in chromosome partitioning
ALX04_RS15650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALX04_RS15705	COG3328	transposase activity
ALX04_RS15720	COG0514	ATP-dependent DNA helicase (RecQ)
ALX04_RS15725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALX04_RS15750	COG3409	Peptidoglycan-binding domain 1 protein
ALX04_RS15760	COG0783	Belongs to the Dps family
ALX04_RS15765	COG1131	(ABC) transporter
ALX04_RS15775	COG1309	transcriptional regulator
ALX04_RS15780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ALX04_RS15800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALX04_RS15810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALX04_RS15815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALX04_RS15855	COG2826	transposase and inactivated derivatives, IS30 family
ALX04_RS15935	COG2801	Transposase and inactivated derivatives
ALX04_RS15950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALX04_RS15990	COG1418	mRNA catabolic process
ALX04_RS15995	COG0477	Major facilitator Superfamily
ALX04_RS16010	COG3328	transposase activity
ALX04_RS16015	COG0745	RESPONSE REGULATOR receiver
ALX04_RS16020	COG3158	transport of potassium into the cell
ALX04_RS16050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALX04_RS16060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides