locus-tag	class	description
LP475_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LP475_RS00010	COG0592	DNA-directed DNA polymerase activity
LP475_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LP475_RS00025	COG0187	DNA topoisomerase II activity
LP475_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LP475_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LP475_RS00040	COG0629	single-stranded DNA binding
LP475_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LP475_RS00060	COG0359	binds to the 23S rRNA
LP475_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
LP475_RS00070	COG2814	Major facilitator Superfamily
LP475_RS00085	COG2326	polyphosphate kinase activity
LP475_RS00095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LP475_RS00100	COG0581	inorganic phosphate transmembrane transporter activity
LP475_RS00115	COG0745	RESPONSE REGULATOR receiver
LP475_RS00130	COG0745	RESPONSE REGULATOR receiver
LP475_RS00150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LP475_RS00155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LP475_RS00160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LP475_RS00165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LP475_RS00185	COG0004	ammonium transporteR
LP475_RS00190	COG1765	OsmC-like protein
LP475_RS00200	COG0436	Aminotransferase
LP475_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LP475_RS00225	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LP475_RS00230	COG1074	ATP-dependent DNA helicase activity
LP475_RS00235	COG1609	Transcriptional regulator
LP475_RS00240	COG0183	Belongs to the thiolase family
LP475_RS00255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LP475_RS00265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LP475_RS00270	COG0656	L-ascorbic acid biosynthetic process
LP475_RS00280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LP475_RS00290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LP475_RS00330	COG0366	Alpha amylase catalytic
LP475_RS00355	COG4948	Mandelate Racemase Muconate Lactonizing
LP475_RS00365	COG0583	DNA-binding transcription factor activity
LP475_RS00370	COG0431	NADPH-dependent FMN reductase
LP475_RS00370	COG1053	succinate dehydrogenase
LP475_RS00370	COG3976	FMN-binding domain protein
LP475_RS00375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LP475_RS00385	COG0431	NADPH-dependent FMN reductase
LP475_RS00385	COG3976	FMN-binding domain protein
LP475_RS00385	COG1053	succinate dehydrogenase
LP475_RS00390	COG0431	NADPH-dependent FMN reductase
LP475_RS00400	COG0778	Nitroreductase
LP475_RS00405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LP475_RS00410	COG0765	amino acid transport
LP475_RS00420	COG1113	amino acid transport
LP475_RS00425	COG0667	Aldo Keto reductase
LP475_RS00430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LP475_RS00440	COG1250	3-hydroxyacyl-CoA dehydrogenase
LP475_RS00445	COG1250	3-hydroxyacyl-CoA dehydrogenase
LP475_RS00450	COG0357	Ribosomal RNA small subunit methyltransferase G
LP475_RS00460	COG1192	Involved in chromosome partitioning
LP475_RS00465	COG1475	DNA binding
LP475_RS00475	COG0012	GTP binding
LP475_RS00490	COG2826	transposase and inactivated derivatives, IS30 family
LP475_RS00500	COG0516	GMP reductase activity
LP475_RS00500	COG0517	IMP dehydrogenase activity
LP475_RS00510	COG0745	RESPONSE REGULATOR receiver
LP475_RS00535	COG0540	Belongs to the ATCase OTCase family
LP475_RS00545	COG0167	dihydroorotate dehydrogenase activity
LP475_RS00550	COG0284	orotidine-5'-phosphate decarboxylase activity
LP475_RS00555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LP475_RS00565	COG1215	transferase activity, transferring glycosyl groups
LP475_RS00570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LP475_RS00575	COG0628	permease
LP475_RS00580	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LP475_RS00585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LP475_RS00590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LP475_RS00595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LP475_RS00605	COG3655	Transcriptional regulator
LP475_RS00615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LP475_RS00620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LP475_RS00625	COG0047	phosphoribosylformylglycinamidine synthase activity
LP475_RS00630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LP475_RS00640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LP475_RS00645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LP475_RS00650	COG0138	bifunctional purine biosynthesis protein purh
LP475_RS00665	COG0588	phosphoglycerate mutase activity
LP475_RS00675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LP475_RS00695	COG1733	regulation of RNA biosynthetic process
LP475_RS00705	COG0477	Major facilitator Superfamily
LP475_RS00715	COG1247	-acetyltransferase
LP475_RS00845	COG2217	Heavy metal translocating P-type atpase
LP475_RS00855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LP475_RS00880	COG1393	Belongs to the ArsC family
LP475_RS00885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LP475_RS00890	COG1609	Transcriptional regulator
LP475_RS00900	COG1874	Beta-galactosidase
LP475_RS00905	COG1012	belongs to the aldehyde dehydrogenase family
LP475_RS00910	COG1757	Na H antiporter
LP475_RS00940	COG2207	Transcriptional regulator
LP475_RS00960	COG0656	L-ascorbic acid biosynthetic process
LP475_RS00975	COG2186	Transcriptional regulator
LP475_RS00980	COG1131	(ABC) transporter
LP475_RS00990	COG1302	Protein conserved in bacteria
LP475_RS01015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LP475_RS01020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LP475_RS01050	COG2814	Major facilitator Superfamily
LP475_RS01055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LP475_RS01060	COG0531	amino acid
LP475_RS01075	COG3527	Alpha-acetolactate decarboxylase
LP475_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
LP475_RS01100	COG3973	AAA domain
LP475_RS01105	COG0105	UTP biosynthetic process
LP475_RS01125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LP475_RS01135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LP475_RS01135	COG0248	Ppx GppA phosphatase
LP475_RS01150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LP475_RS01175	COG1126	abc transporter atp-binding protein
LP475_RS01190	COG1801	Protein of unknown function DUF72
LP475_RS01195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP475_RS01195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP475_RS01200	COG0084	hydrolase, TatD family'
LP475_RS01205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LP475_RS01210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LP475_RS01220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LP475_RS01230	COG1121	(ABC) transporter
LP475_RS01235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LP475_RS01240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LP475_RS01245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LP475_RS01250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LP475_RS01270	COG1078	dGTPase activity
LP475_RS01275	COG0095	Lipoate-protein ligase
LP475_RS01285	COG3343	RNA polymerase activity
LP475_RS01290	COG0504	CTP synthase activity
LP475_RS01295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LP475_RS01300	COG0254	rRNA binding
LP475_RS01305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LP475_RS01315	COG3764	Sortase (surface protein transpeptidase)
LP475_RS01320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LP475_RS01325	COG1704	LemA family
LP475_RS01330	COG0501	Belongs to the peptidase M48B family
LP475_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LP475_RS01345	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LP475_RS01355	COG1696	Membrane protein involved in D-alanine export
LP475_RS01360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LP475_RS01370	COG0736	holo-[acyl-carrier-protein] synthase activity
LP475_RS01375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LP475_RS01380	COG2337	Toxic component of a toxin-antitoxin (TA) module
LP475_RS01390	COG0402	S-adenosylhomocysteine deaminase activity
LP475_RS01405	COG0193	aminoacyl-tRNA hydrolase activity
LP475_RS01410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LP475_RS01415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LP475_RS01425	COG1098	S1 RNA binding domain
LP475_RS01430	COG0037	tRNA processing
LP475_RS01435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LP475_RS01445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LP475_RS01450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LP475_RS01455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LP475_RS01530	COG3104	oligopeptide transport
LP475_RS01545	COG1033	growth of symbiont in host cell
LP475_RS01545	COG2409	Drug exporters of the RND superfamily
LP475_RS01555	COG2814	Major facilitator Superfamily
LP475_RS01565	COG1794	racemase activity, acting on amino acids and derivatives
LP475_RS01570	COG2188	Transcriptional regulator
LP475_RS01575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LP475_RS01580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LP475_RS01585	COG2183	response to ionizing radiation
LP475_RS01590	COG3091	SprT-like family
LP475_RS01600	COG3250	beta-galactosidase activity
LP475_RS01605	COG3250	beta-galactosidase activity
LP475_RS01635	COG0588	phosphoglycerate mutase activity
LP475_RS01655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LP475_RS01665	COG0756	dUTP diphosphatase activity
LP475_RS01670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LP475_RS01675	COG4956	integral membrane protein (PIN domain superfamily)
LP475_RS01680	COG0215	cysteine-tRNA ligase activity
LP475_RS01685	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LP475_RS01690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LP475_RS01710	COG0250	Participates in transcription elongation, termination and antitermination
LP475_RS01715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LP475_RS01735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LP475_RS01740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LP475_RS01745	COG0222	ribosome binding
LP475_RS01750	COG1064	alcohol dehydrogenase
LP475_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
LP475_RS01785	COG1454	alcohol dehydrogenase
LP475_RS01795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LP475_RS01800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LP475_RS01805	COG0590	tRNA wobble adenosine to inosine editing
LP475_RS01815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LP475_RS01820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LP475_RS01825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LP475_RS01835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LP475_RS01840	COG3870	Protein conserved in bacteria
LP475_RS01845	COG0470	DNA polymerase III
LP475_RS01850	COG4467	Involved in initiation control of chromosome replication
LP475_RS01880	COG1215	transferase activity, transferring glycosyl groups
LP475_RS01895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LP475_RS01905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LP475_RS01925	COG1214	PFAM Peptidase M22, glycoprotease
LP475_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LP475_RS01945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LP475_RS01950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LP475_RS01955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LP475_RS01960	COG0488	(ABC) transporter
LP475_RS01965	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LP475_RS01970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LP475_RS01975	COG0459	protein refolding
LP475_RS01980	COG0531	amino acid
LP475_RS01985	COG0531	amino acid
LP475_RS01995	COG1739	Uncharacterized protein family UPF0029
LP475_RS02015	COG0653	protein targeting
LP475_RS02030	COG1950	PFAM Membrane protein of
LP475_RS02035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LP475_RS02040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LP475_RS02045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LP475_RS02055	COG0492	ferredoxin-NADP+ reductase activity
LP475_RS02065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LP475_RS02090	COG0556	nucleotide-excision repair
LP475_RS02095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LP475_RS02100	COG1683	Conserved Protein
LP475_RS02105	COG1660	Displays ATPase and GTPase activities
LP475_RS02110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LP475_RS02115	COG1481	regulation of sporulation
LP475_RS02120	COG0740	serine-type endopeptidase activity
LP475_RS02140	COG0149	triose-phosphate isomerase activity
LP475_RS02145	COG0148	phosphopyruvate hydratase activity
LP475_RS02155	COG1113	amino acid transport
LP475_RS02160	COG0038	chloride channel
LP475_RS02175	COG0557	exoribonuclease II activity
LP475_RS02180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LP475_RS02190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LP475_RS02195	COG0280	phosphate acetyltransferase
LP475_RS02205	COG0802	atpase or kinase
LP475_RS02215	COG2176	DNA-directed DNA polymerase activity
LP475_RS02220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LP475_RS02245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LP475_RS02250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LP475_RS02260	COG2755	lipolytic protein G-D-S-L family
LP475_RS02260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LP475_RS02270	COG0561	phosphatase activity
LP475_RS02300	COG0431	NADPH-dependent FMN reductase
LP475_RS02320	COG0745	RESPONSE REGULATOR receiver
LP475_RS02325	COG5002	protein histidine kinase activity
LP475_RS02325	COG3850	Histidine kinase
LP475_RS02330	COG4975	Glucose uptake
LP475_RS02335	COG0166	Belongs to the GPI family
LP475_RS02345	COG0745	RESPONSE REGULATOR receiver
LP475_RS02350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LP475_RS02360	COG0697	spore germination
LP475_RS02395	COG1846	Transcriptional regulator
LP475_RS02410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LP475_RS02415	COG2235	arginine
LP475_RS02440	COG3442	glutamine amidotransferase
LP475_RS02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LP475_RS02450	COG1435	thymidine kinase activity
LP475_RS02460	COG2890	protein-(glutamine-N5) methyltransferase activity
LP475_RS02465	COG0009	L-threonylcarbamoyladenylate synthase
LP475_RS02470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LP475_RS02485	COG0356	it plays a direct role in the translocation of protons across the membrane
LP475_RS02490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LP475_RS02495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LP475_RS02500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LP475_RS02505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LP475_RS02510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LP475_RS02515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LP475_RS02520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LP475_RS02530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LP475_RS02535	COG1077	Cell shape determining protein MreB Mrl
LP475_RS02540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LP475_RS02550	COG0772	Belongs to the SEDS family
LP475_RS02555	COG0509	glycine decarboxylation via glycine cleavage system
LP475_RS02560	COG1181	Belongs to the D-alanine--D-alanine ligase family
LP475_RS02575	COG1609	Transcriptional regulator
LP475_RS02590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LP475_RS02605	COG3022	response to hydroperoxide
LP475_RS02610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LP475_RS02615	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LP475_RS02620	COG1104	cysteine desulfurase activity
LP475_RS02625	COG0301	tRNA thio-modification
LP475_RS02630	COG0525	valine-tRNA ligase activity
LP475_RS02635	COG0285	dihydrofolate synthase activity
LP475_RS02640	COG2003	Belongs to the UPF0758 family
LP475_RS02645	COG1077	Cell shape determining protein MreB Mrl
LP475_RS02660	COG0765	amino acid transport
LP475_RS02665	COG1126	abc transporter atp-binding protein
LP475_RS02670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP475_RS02675	COG0612	Peptidase, M16
LP475_RS02680	COG0612	Peptidase, M16
LP475_RS02685	COG1426	Protein conserved in bacteria
LP475_RS02690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LP475_RS02695	COG1058	Belongs to the CinA family
LP475_RS02695	COG1546	Belongs to the CinA family
LP475_RS02700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LP475_RS02705	COG1418	mRNA catabolic process
LP475_RS02715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LP475_RS02720	COG0632	four-way junction helicase activity
LP475_RS02725	COG2255	four-way junction helicase activity
LP475_RS02735	COG1862	Preprotein translocase
LP475_RS02740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LP475_RS02745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LP475_RS02750	COG0513	Belongs to the DEAD box helicase family
LP475_RS02755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LP475_RS02760	COG4472	Bacterial protein of unknown function (DUF965)
LP475_RS02765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LP475_RS02770	COG3906	Belongs to the UPF0473 family
LP475_RS02780	COG1193	negative regulation of DNA recombination
LP475_RS02785	COG3118	belongs to the thioredoxin family
LP475_RS02795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LP475_RS02800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LP475_RS02805	COG0622	Phosphoesterase
LP475_RS02810	COG0517	IMP dehydrogenase activity
LP475_RS02815	COG0561	phosphatase activity
LP475_RS02820	COG0668	transmembrane transport
LP475_RS02835	COG1609	Transcriptional regulator
LP475_RS02845	COG0217	transcriptional regulatory protein
LP475_RS02850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LP475_RS02855	COG1459	type II secretion system
LP475_RS02860	COG4537	Required for transformation and DNA binding
LP475_RS02880	COG0827	DNA restriction-modification system
LP475_RS02885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LP475_RS02895	COG4470	Protein conserved in bacteria
LP475_RS02910	COG0586	Pfam SNARE associated Golgi protein
LP475_RS03030	COG1393	Belongs to the ArsC family
LP475_RS03035	COG4862	establishment of competence for transformation
LP475_RS03045	COG4690	dipeptidase activity
LP475_RS03055	COG2357	RelA SpoT domain protein
LP475_RS03060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LP475_RS03065	COG0564	pseudouridine synthase activity
LP475_RS03070	COG2706	6-phosphogluconolactonase activity
LP475_RS03075	COG0500	methyltransferase
LP475_RS03080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LP475_RS03085	COG1674	ftsk spoiiie
LP475_RS03100	COG2001	Belongs to the MraZ family
LP475_RS03105	COG0275	rRNA processing
LP475_RS03115	COG0768	penicillin binding
LP475_RS03120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LP475_RS03125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LP475_RS03130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LP475_RS03140	COG0849	cell division
LP475_RS03150	COG1799	cell septum assembly
LP475_RS03160	COG2302	S4 RNA-binding domain
LP475_RS03165	COG3599	regulation of cell shape
LP475_RS03175	COG1278	Cold shock
LP475_RS03180	COG0494	nUDIX hydrolase
LP475_RS03190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LP475_RS03195	COG1104	cysteine desulfurase activity
LP475_RS03205	COG0482	sulfurtransferase activity
LP475_RS03210	COG0588	phosphoglycerate mutase activity
LP475_RS03220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LP475_RS03225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LP475_RS03235	COG0527	aspartate kinase activity
LP475_RS03240	COG0019	diaminopimelate decarboxylase activity
LP475_RS03245	COG2171	N-acyltransferase activity
LP475_RS03250	COG1473	amidohydrolase
LP475_RS03255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LP475_RS03260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LP475_RS03265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LP475_RS03280	COG1597	lipid kinase activity
LP475_RS03285	COG5503	Protein of unknown function (DUF1447)
LP475_RS03295	COG0242	peptide deformylase activity
LP475_RS03325	COG0483	inositol monophosphate 1-phosphatase activity
LP475_RS03330	COG1217	gtp-binding protein TYPA
LP475_RS03335	COG0772	Belongs to the SEDS family
LP475_RS03340	COG4471	UPF0298 protein
LP475_RS03345	COG0742	ribosomal rna small subunit methyltransferase
LP475_RS03350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LP475_RS03355	COG3480	Lon protease (S16) C-terminal proteolytic domain
LP475_RS03365	COG1555	photosystem II stabilization
LP475_RS03365	COG1596	polysaccharide export
LP475_RS03370	COG2131	deaminase
LP475_RS03375	COG2333	competence protein COMEC
LP475_RS03375	COG0658	competence protein
LP475_RS03380	COG1466	dna polymerase III delta subunit
LP475_RS03385	COG0268	Binds directly to 16S ribosomal RNA
LP475_RS03390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LP475_RS03405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LP475_RS03410	COG0544	peptidyl-prolyl cis-trans isomerase activity
LP475_RS03415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LP475_RS03420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LP475_RS03430	COG0322	excinuclease ABC activity
LP475_RS03435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LP475_RS03440	COG1234	tRNA 3'-trailer cleavage
LP475_RS03445	COG0300	oxidoreductase activity
LP475_RS03450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LP475_RS03450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LP475_RS03455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LP475_RS03470	COG0328	RNA-DNA hybrid ribonuclease activity
LP475_RS03475	COG3425	synthase
LP475_RS03480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LP475_RS03485	COG4224	UPF0291 protein
LP475_RS03490	COG3763	UPF0154 protein
LP475_RS03495	COG0204	Acyl-transferase
LP475_RS03500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LP475_RS03505	COG2827	Endonuclease containing a URI domain
LP475_RS03510	COG0052	Belongs to the universal ribosomal protein uS2 family
LP475_RS03515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LP475_RS03525	COG0233	cytoplasmic translational termination
LP475_RS03530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LP475_RS03535	COG4589	Belongs to the CDS family
LP475_RS03540	COG0750	zinc metalloprotease
LP475_RS03545	COG0442	prolyl-tRNA aminoacylation
LP475_RS03550	COG2176	DNA-directed DNA polymerase activity
LP475_RS03555	COG0779	Required for maturation of 30S ribosomal subunits
LP475_RS03560	COG0195	Participates in both transcription termination and antitermination
LP475_RS03565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LP475_RS03570	COG1358	cellular component organization or biogenesis
LP475_RS03575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LP475_RS03580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LP475_RS03585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LP475_RS03590	COG0196	riboflavin kinase activity
LP475_RS03595	COG1285	pathogenesis
LP475_RS03605	COG1420	regulation of RNA biosynthetic process
LP475_RS03610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LP475_RS03615	COG0443	Heat shock 70 kDa protein
LP475_RS03620	COG0484	heat shock protein binding
LP475_RS03625	COG0481	GTPase activity
LP475_RS03640	COG0039	L-malate dehydrogenase activity
LP475_RS03650	COG2264	protein methyltransferase activity
LP475_RS03655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LP475_RS03665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LP475_RS03670	COG1490	D-aminoacyl-tRNA deacylase activity
LP475_RS03675	COG3001	Fructosamine kinase
LP475_RS03680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LP475_RS03690	COG1126	abc transporter atp-binding protein
LP475_RS03695	COG0765	amino acid transport
LP475_RS03700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LP475_RS03705	COG1610	YqeY-like protein
LP475_RS03715	COG1702	phosphate starvation-inducible protein PhoH
LP475_RS03720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LP475_RS03730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LP475_RS03735	COG1381	Involved in DNA repair and RecF pathway recombination
LP475_RS03740	COG0752	glycyl-tRNA synthetase alpha subunit
LP475_RS03745	COG0751	glycine-tRNA ligase activity
LP475_RS03750	COG0358	DNA primase activity
LP475_RS03755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LP475_RS03760	COG0436	Aminotransferase
LP475_RS03765	COG2384	SAM-dependent methyltransferase
LP475_RS03770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LP475_RS03775	COG2195	Cleaves the N-terminal amino acid of tripeptides
LP475_RS03785	COG0587	DNA-directed DNA polymerase activity
LP475_RS03810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LP475_RS03815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LP475_RS03820	COG1187	pseudouridine synthase activity
LP475_RS03825	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LP475_RS03835	COG0514	ATP-dependent DNA helicase (RecQ)
LP475_RS03845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LP475_RS03850	COG0539	negative regulation of cytoplasmic translation
LP475_RS03855	COG1160	GTP binding
LP475_RS03875	COG0617	tRNA 3'-terminal CCA addition
LP475_RS03880	COG0488	(ABC) transporter
LP475_RS03885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LP475_RS03890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LP475_RS03895	COG1272	protein, Hemolysin III
LP475_RS03900	COG1307	EDD domain protein, DegV family
LP475_RS03915	COG4479	Belongs to the UPF0346 family
LP475_RS03925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LP475_RS03930	COG0758	DNA mediated transformation
LP475_RS03935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LP475_RS03945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LP475_RS03950	COG0187	DNA topoisomerase II activity
LP475_RS03955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LP475_RS03970	COG1227	inorganic diphosphatase activity
LP475_RS03975	COG4690	dipeptidase activity
LP475_RS03995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LP475_RS04010	COG0477	Major facilitator Superfamily
LP475_RS04015	COG1846	Transcriptional regulator
LP475_RS04025	COG0719	Fe-S assembly protein
LP475_RS04030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LP475_RS04040	COG0719	Fe-S assembly protein
LP475_RS04045	COG2151	metal-sulfur cluster biosynthetic enzyme
LP475_RS04055	COG0446	pyridine nucleotide-disulphide oxidoreductase
LP475_RS04095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LP475_RS04125	COG4475	Protein of unknown function (DUF436)
LP475_RS04155	COG0656	L-ascorbic acid biosynthetic process
LP475_RS04165	COG1733	regulation of RNA biosynthetic process
LP475_RS04195	COG0133	tryptophan synthase activity
LP475_RS04225	COG1063	alcohol dehydrogenase
LP475_RS04250	COG0561	phosphatase activity
LP475_RS04280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LP475_RS04320	COG1113	amino acid transport
LP475_RS04330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LP475_RS04345	COG0708	Exodeoxyribonuclease III
LP475_RS04355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LP475_RS04380	COG1253	flavin adenine dinucleotide binding
LP475_RS04385	COG1132	(ABC) transporter
LP475_RS04400	COG2814	Major facilitator Superfamily
LP475_RS04405	COG2814	Major facilitator Superfamily
LP475_RS04410	COG0514	ATP-dependent DNA helicase (RecQ)
LP475_RS04415	COG0656	L-ascorbic acid biosynthetic process
LP475_RS04420	COG1597	lipid kinase activity
LP475_RS04440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LP475_RS04455	COG0583	DNA-binding transcription factor activity
LP475_RS04460	COG1687	branched-chain amino acid
LP475_RS04465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LP475_RS04485	COG1335	isochorismatase
LP475_RS04490	COG1442	glycosyl transferase family 8
LP475_RS04505	COG1307	EDD domain protein, DegV family
LP475_RS04510	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LP475_RS04540	COG0477	Major facilitator Superfamily
LP475_RS04545	COG2814	Major facilitator Superfamily
LP475_RS04560	COG0626	cystathionine gamma-synthase activity
LP475_RS04570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LP475_RS04570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LP475_RS04580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LP475_RS04590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LP475_RS04595	COG0095	Lipoate-protein ligase
LP475_RS04605	COG1902	pentaerythritol trinitrate reductase activity
LP475_RS04610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LP475_RS04615	COG2252	PERMEase
LP475_RS04620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LP475_RS04630	COG1715	Restriction endonuclease
LP475_RS04650	COG1002	Type II restriction enzyme, methylase subunits
LP475_RS04665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LP475_RS04670	COG1335	isochorismatase
LP475_RS04675	COG3201	nicotinamide mononucleotide transporter
LP475_RS04710	COG1811	Na channel or pump
LP475_RS04715	COG4975	Glucose uptake
LP475_RS04730	COG0419	ATPase involved in DNA repair
LP475_RS04735	COG0420	3'-5' exonuclease activity
LP475_RS04770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LP475_RS04775	COG0505	Belongs to the CarA family
LP475_RS04780	COG0564	pseudouridine synthase activity
LP475_RS04785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LP475_RS04795	COG0328	RNA-DNA hybrid ribonuclease activity
LP475_RS04805	COG2610	gluconate transmembrane transporter activity
LP475_RS04810	COG1609	Transcriptional regulator
LP475_RS04815	COG2814	Major facilitator Superfamily
LP475_RS04825	COG0116	Belongs to the methyltransferase superfamily
LP475_RS04830	COG0656	L-ascorbic acid biosynthetic process
LP475_RS04840	COG3599	regulation of cell shape
LP475_RS04845	COG4474	Belongs to the UPF0398 family
LP475_RS04850	COG3331	DNA recombination
LP475_RS04855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LP475_RS04860	COG0697	spore germination
LP475_RS04865	COG3935	DnaD domain protein
LP475_RS04875	COG1199	ATP-dependent helicase activity
LP475_RS04875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LP475_RS04880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LP475_RS04915	COG1346	cytolysis
LP475_RS04930	COG3279	Response regulator of the LytR AlgR family
LP475_RS04935	COG3275	phosphorelay sensor kinase activity
LP475_RS04945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LP475_RS04945	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LP475_RS04950	COG0561	phosphatase activity
LP475_RS04960	COG0531	amino acid
LP475_RS04995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LP475_RS05030	COG1609	Transcriptional regulator
LP475_RS05040	COG1428	Deoxynucleoside kinase
LP475_RS05045	COG1388	LysM domain
LP475_RS05045	COG1705	Flagellar rod assembly protein muramidase FlgJ
LP475_RS05060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LP475_RS05065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LP475_RS05075	COG1088	dTDP-glucose 4,6-dehydratase activity
LP475_RS05130	COG1216	Glycosyl transferase, family 2
LP475_RS05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LP475_RS05165	COG4464	protein tyrosine phosphatase activity
LP475_RS05170	COG0489	protein tyrosine kinase activity
LP475_RS05180	COG1316	TRANSCRIPTIONal
LP475_RS05220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LP475_RS05225	COG1942	4-Oxalocrotonate Tautomerase
LP475_RS05240	COG0569	domain protein
LP475_RS05240	COG0475	glutathione-regulated potassium exporter activity
LP475_RS05255	COG0450	alkyl hydroperoxide reductase
LP475_RS05265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LP475_RS05275	COG2814	Major facilitator Superfamily
LP475_RS05295	COG0509	glycine decarboxylation via glycine cleavage system
LP475_RS05310	COG0363	glucosamine-6-phosphate deaminase activity
LP475_RS05315	COG2814	Major facilitator Superfamily
LP475_RS05330	COG0335	large ribosomal subunit rRNA binding
LP475_RS05335	COG0531	amino acid
LP475_RS05340	COG0336	Belongs to the RNA methyltransferase TrmD family
LP475_RS05345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LP475_RS05350	COG1837	Belongs to the UPF0109 family
LP475_RS05355	COG0228	four-way junction DNA binding
LP475_RS05375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LP475_RS05380	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LP475_RS05385	COG0552	protein localization to endoplasmic reticulum
LP475_RS05390	COG1196	nuclear chromosome segregation
LP475_RS05395	COG0571	ribonuclease III activity
LP475_RS05400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LP475_RS05405	COG0416	fatty acid biosynthetic process
LP475_RS05410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LP475_RS05415	COG1461	Dihydroxyacetone kinase
LP475_RS05425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LP475_RS05430	COG1564	THIamine pyrophosphokinase
LP475_RS05435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LP475_RS05440	COG1162	GTPase activity
LP475_RS05445	COG2815	serine threonine protein kinase
LP475_RS05445	COG0515	serine threonine protein kinase
LP475_RS05450	COG0631	protein serine/threonine phosphatase activity
LP475_RS05455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LP475_RS05455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LP475_RS05460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LP475_RS05465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LP475_RS05470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LP475_RS05475	COG1758	RNA polymerase activity
LP475_RS05480	COG0194	GDP metabolic process
LP475_RS05490	COG0497	DNA recombination
LP475_RS05495	COG1438	arginine binding
LP475_RS05500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LP475_RS05510	COG1722	exodeoxyribonuclease VII activity
LP475_RS05515	COG1570	exodeoxyribonuclease VII activity
LP475_RS05520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LP475_RS05525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LP475_RS05530	COG1302	Protein conserved in bacteria
LP475_RS05540	COG0006	proline dipeptidase activity
LP475_RS05545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LP475_RS05555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LP475_RS05605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LP475_RS05615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LP475_RS05625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LP475_RS05630	COG1940	carbohydrate kinase activity
LP475_RS05640	COG0705	Rhomboid family
LP475_RS05640	COG0457	Tetratricopeptide repeat
LP475_RS05645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LP475_RS05650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LP475_RS05655	COG0768	penicillin binding
LP475_RS05670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LP475_RS05675	COG0572	uridine kinase
LP475_RS05685	COG0072	phenylalanine-tRNA ligase activity
LP475_RS05685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP475_RS05690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LP475_RS05695	COG1733	regulation of RNA biosynthetic process
LP475_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LP475_RS05715	COG0706	membrane insertase activity
LP475_RS05720	COG0242	peptide deformylase activity
LP475_RS05735	COG5002	protein histidine kinase activity
LP475_RS05740	COG0745	RESPONSE REGULATOR receiver
LP475_RS05745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LP475_RS05755	COG1323	Belongs to the UPF0348 family
LP475_RS05760	COG2226	methyltransferase
LP475_RS05765	COG0799	negative regulation of ribosome biogenesis
LP475_RS05770	COG1713	HD superfamily hydrolase involved in NAD metabolism
LP475_RS05775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LP475_RS05785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LP475_RS05790	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LP475_RS05795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LP475_RS05800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LP475_RS05805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LP475_RS05810	COG1484	DNA-dependent DNA replication
LP475_RS05820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LP475_RS05825	COG0237	dephospho-CoA kinase activity
LP475_RS05830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LP475_RS05835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LP475_RS05835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LP475_RS05845	COG0670	Belongs to the BI1 family
LP475_RS05850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LP475_RS05855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP475_RS05860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LP475_RS05870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LP475_RS05875	COG4473	ABC transporter
LP475_RS05880	COG1131	(ABC) transporter
LP475_RS05885	COG0537	adenosine 5'-monophosphoramidase activity
LP475_RS05900	COG3679	Belongs to the UPF0342 family
LP475_RS05905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LP475_RS05915	COG0018	arginyl-trna synthetase
LP475_RS05920	COG0351	phosphomethylpyrimidine kinase
LP475_RS05930	COG2244	polysaccharide biosynthetic process
LP475_RS05935	COG1598	PFAM Uncharacterised protein family UPF0150
LP475_RS05940	COG0495	leucyl-tRNA aminoacylation
LP475_RS05945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LP475_RS05950	COG2818	Glycosylase
LP475_RS05955	COG2814	Major facilitator Superfamily
LP475_RS05965	COG1113	amino acid transport
LP475_RS05990	COG1607	acyl-coa hydrolase
LP475_RS06005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LP475_RS06025	COG0602	queuosine metabolic process
LP475_RS06115	COG0438	transferase activity, transferring glycosyl groups
LP475_RS06120	COG0438	transferase activity, transferring glycosyl groups
LP475_RS06125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LP475_RS06140	COG0542	response to heat
LP475_RS06145	COG4684	Psort location CytoplasmicMembrane, score
LP475_RS06155	COG0628	permease
LP475_RS06165	COG1316	TRANSCRIPTIONal
LP475_RS06170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LP475_RS06210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LP475_RS06255	COG1442	glycosyl transferase family 8
LP475_RS06255	COG1216	Glycosyl transferase, family 2
LP475_RS06280	COG1705	Flagellar rod assembly protein muramidase FlgJ
LP475_RS06290	COG0438	transferase activity, transferring glycosyl groups
LP475_RS06335	COG0562	UDP-galactopyranose mutase
LP475_RS06355	COG0463	Glycosyl transferase, family 2
LP475_RS06365	COG2137	regulation of response to DNA damage stimulus
LP475_RS06380	COG1295	ribonuclease BN
LP475_RS06390	COG0024	Methionine aminopeptidase
LP475_RS06395	COG0716	FMN binding
LP475_RS06400	COG2246	polysaccharide biosynthetic process
LP475_RS06405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LP475_RS06420	COG0673	inositol 2-dehydrogenase activity
LP475_RS06430	COG1611	Belongs to the LOG family
LP475_RS06475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LP475_RS06500	COG1597	lipid kinase activity
LP475_RS06505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LP475_RS06510	COG0154	amidase activity
LP475_RS06515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LP475_RS06520	COG4851	CamS sex pheromone cAM373 precursor
LP475_RS06525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LP475_RS06535	COG0534	Mate efflux family protein
LP475_RS06545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LP475_RS06550	COG1705	Flagellar rod assembly protein muramidase FlgJ
LP475_RS06560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LP475_RS06565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LP475_RS06570	COG0101	tRNA pseudouridine synthase activity
LP475_RS06590	COG0203	ribosomal protein L17
LP475_RS06595	COG0202	RNA polymerase activity
LP475_RS06600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LP475_RS06605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LP475_RS06610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LP475_RS06615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LP475_RS06630	COG0200	Binds to the 23S rRNA
LP475_RS06635	COG1841	ribosomal large subunit assembly
LP475_RS06640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LP475_RS06645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LP475_RS06650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LP475_RS06655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LP475_RS06660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LP475_RS06665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LP475_RS06670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LP475_RS06675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LP475_RS06685	COG0255	Belongs to the universal ribosomal protein uL29 family
LP475_RS06690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LP475_RS06695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LP475_RS06700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LP475_RS06705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LP475_RS06710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LP475_RS06715	COG0089	rRNA binding
LP475_RS06720	COG0088	Forms part of the polypeptide exit tunnel
LP475_RS06725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LP475_RS06730	COG0051	transcription antitermination factor activity, RNA binding
LP475_RS06735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LP475_RS06740	COG0049	tRNA binding
LP475_RS06745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LP475_RS06760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LP475_RS06765	COG0085	RNA polymerase activity
LP475_RS06775	COG0542	response to heat
LP475_RS06780	COG4463	regulation of RNA biosynthetic process
LP475_RS06785	COG1064	alcohol dehydrogenase
LP475_RS06845	COG1428	Deoxynucleoside kinase
LP475_RS06850	COG0833	amino acid
LP475_RS06875	COG1278	Cold shock
LP475_RS06885	COG1230	cation diffusion facilitator family transporter
LP475_RS06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP475_RS06915	COG0765	amino acid transport
LP475_RS06920	COG0765	amino acid transport
LP475_RS06945	COG2814	Major facilitator Superfamily
LP475_RS06955	COG0564	pseudouridine synthase activity
LP475_RS06965	COG0392	lysyltransferase activity
LP475_RS06965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LP475_RS06975	COG0693	protein deglycase activity
LP475_RS06985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LP475_RS06990	COG0477	Major facilitator Superfamily
LP475_RS07005	COG0583	DNA-binding transcription factor activity
LP475_RS07010	COG0471	metal ion transport
LP475_RS07025	COG0114	fumarate hydratase activity
LP475_RS07030	COG0281	malic enzyme
LP475_RS07060	COG2017	converts alpha-aldose to the beta-anomer
LP475_RS07070	COG1686	Belongs to the peptidase S11 family
LP475_RS07095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LP475_RS07100	COG1288	antiporter activity
LP475_RS07110	COG0488	(ABC) transporter
LP475_RS07120	COG0657	acetylesterase activity
LP475_RS07120	COG2755	lipolytic protein G-D-S-L family
LP475_RS07130	COG0656	L-ascorbic acid biosynthetic process
LP475_RS07140	COG0569	domain protein
LP475_RS07145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LP475_RS07170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LP475_RS07175	COG2826	transposase and inactivated derivatives, IS30 family
LP475_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
LP475_RS07200	COG0519	Catalyzes the synthesis of GMP from XMP
LP475_RS07205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LP475_RS07215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LP475_RS07225	COG1072	(Pantothenic acid kinase))
LP475_RS07230	COG2217	Heavy metal translocating P-type atpase
LP475_RS07245	COG1368	sulfuric ester hydrolase activity
LP475_RS07255	COG3973	AAA domain
LP475_RS07260	COG0586	Pfam SNARE associated Golgi protein
LP475_RS07265	COG0588	phosphoglycerate mutase activity
LP475_RS07270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LP475_RS07280	COG1511	domain protein
LP475_RS07280	COG1511	domain protein
LP475_RS07290	COG2017	converts alpha-aldose to the beta-anomer
LP475_RS07295	COG1983	PspC domain protein
LP475_RS07300	COG0738	Major facilitator superfamily
LP475_RS07305	COG1869	D-ribose catabolic process
LP475_RS07325	COG0194	GDP metabolic process
LP475_RS07335	COG0531	amino acid
LP475_RS07340	COG0531	amino acid
LP475_RS07350	COG1177	transmembrane transport
LP475_RS07360	COG3842	ATPase activity
LP475_RS07365	COG2936	dipeptidyl-peptidase activity
LP475_RS07370	COG2267	carboxylic ester hydrolase activity
LP475_RS07375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LP475_RS07395	COG2404	hydrolase activity, acting on ester bonds
LP475_RS07405	COG1114	Component of the transport system for branched-chain amino acids
LP475_RS07410	COG0784	Response regulator, receiver
LP475_RS07415	COG3290	protein histidine kinase activity
LP475_RS07420	COG1288	antiporter activity
LP475_RS07435	COG1368	sulfuric ester hydrolase activity
LP475_RS07445	COG1136	(ABC) transporter
LP475_RS07450	COG0577	efflux transmembrane transporter activity
LP475_RS07450	COG1136	(ABC) transporter
LP475_RS07465	COG1705	Flagellar rod assembly protein muramidase FlgJ
LP475_RS07485	COG2814	Major facilitator Superfamily
LP475_RS07490	COG0124	histidyl-tRNA synthetase
LP475_RS07495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LP475_RS07505	COG3189	MarR family transcriptional regulator
LP475_RS07510	COG2094	Belongs to the DNA glycosylase MPG family
LP475_RS07530	COG3590	peptidase
LP475_RS07535	COG1395	domain, Protein
LP475_RS07545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LP475_RS07560	COG1609	Transcriptional regulator
LP475_RS07565	COG0166	Belongs to the GPI family
LP475_RS07570	COG1940	carbohydrate kinase activity
LP475_RS07585	COG1136	(ABC) transporter
LP475_RS07590	COG0577	efflux transmembrane transporter activity
LP475_RS07600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LP475_RS07605	COG0789	Transcriptional regulator
LP475_RS07615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LP475_RS07630	COG1136	(ABC) transporter
LP475_RS07635	COG2205	protein histidine kinase activity
LP475_RS07640	COG0745	RESPONSE REGULATOR receiver
LP475_RS07650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LP475_RS07675	COG1881	PFAM PEBP family protein
LP475_RS07680	COG2365	Tyrosine phosphatase family
LP475_RS07690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LP475_RS07695	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LP475_RS07700	COG1609	Transcriptional regulator
LP475_RS07705	COG0586	Pfam SNARE associated Golgi protein
LP475_RS07720	COG1522	sequence-specific DNA binding
LP475_RS07730	COG2190	(PTS) system
LP475_RS07730	COG2211	Major facilitator Superfamily
LP475_RS07735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LP475_RS07750	COG0640	Transcriptional regulator
LP475_RS07755	COG2807	transmembrane transport
LP475_RS07785	COG1846	Transcriptional regulator
LP475_RS07825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LP475_RS07830	COG2188	Transcriptional regulator
LP475_RS07860	COG1114	Component of the transport system for branched-chain amino acids
LP475_RS07865	COG1940	carbohydrate kinase activity
LP475_RS07885	COG0095	Lipoate-protein ligase
LP475_RS07905	COG2814	Major facilitator Superfamily
LP475_RS07915	COG1396	sequence-specific DNA binding
LP475_RS07925	COG3759	membrane
LP475_RS07930	COG0025	NhaP-type Na H and K H
LP475_RS07950	COG1122	ATPase activity
LP475_RS07975	COG0492	ferredoxin-NADP+ reductase activity
LP475_RS07985	COG2151	metal-sulfur cluster biosynthetic enzyme
LP475_RS07990	COG0385	Bile acid
LP475_RS08000	COG1376	ErfK ybiS ycfS ynhG family protein
LP475_RS08015	COG1686	Belongs to the peptidase S11 family
LP475_RS08025	COG1368	sulfuric ester hydrolase activity
LP475_RS08035	COG0588	phosphoglycerate mutase activity
LP475_RS08040	COG0436	Aminotransferase
LP475_RS08045	COG1757	Na H antiporter
LP475_RS08060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LP475_RS08070	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LP475_RS08075	COG0564	pseudouridine synthase activity
LP475_RS08080	COG0861	Integral membrane protein TerC family
LP475_RS08090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LP475_RS08090	COG0574	Belongs to the PEP-utilizing enzyme family
LP475_RS08110	COG4120	Belongs to the binding-protein-dependent transport system permease family
LP475_RS08125	COG0488	(ABC) transporter
LP475_RS08140	COG1914	H( )-stimulated, divalent metal cation uptake system
LP475_RS08175	COG0531	amino acid
LP475_RS08185	COG0778	Nitroreductase
LP475_RS08190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LP475_RS08220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LP475_RS08225	COG1695	Transcriptional regulator
LP475_RS08230	COG3479	Phenolic acid decarboxylase
LP475_RS08235	COG0583	DNA-binding transcription factor activity
LP475_RS08240	COG0110	maltose O-acetyltransferase activity
LP475_RS08265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LP475_RS08280	COG2261	transglycosylase associated protein
LP475_RS08305	COG3579	cysteine-type endopeptidase activity
LP475_RS08320	COG0110	maltose O-acetyltransferase activity
LP475_RS08335	COG1609	Transcriptional regulator
LP475_RS08350	COG0308	aminopeptidase N
LP475_RS08360	COG0546	phosphoglycolate phosphatase activity
LP475_RS08380	COG4720	Psort location CytoplasmicMembrane, score
LP475_RS08385	COG2502	aspartate--ammonia ligase
LP475_RS08390	COG0017	Asparaginyl-tRNA synthetase
LP475_RS08410	COG0252	asparaginase activity
LP475_RS08420	COG2084	Dehydrogenase
LP475_RS08450	COG1732	Glycine betaine
LP475_RS08455	COG1959	2 iron, 2 sulfur cluster binding
LP475_RS08465	COG0583	DNA-binding transcription factor activity
LP475_RS08490	COG2610	gluconate transmembrane transporter activity
LP475_RS08510	COG0583	DNA-binding transcription factor activity
LP475_RS08515	COG2706	6-phosphogluconolactonase activity
LP475_RS08520	COG4948	Mandelate Racemase Muconate Lactonizing
LP475_RS08530	COG0471	metal ion transport
LP475_RS08545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LP475_RS08550	COG0367	asparagine synthase
LP475_RS08560	COG0445	tRNA wobble uridine modification
LP475_RS08565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LP475_RS08570	COG1418	mRNA catabolic process
LP475_RS08575	COG0706	membrane insertase activity
LP475_RS08580	COG0594	ribonuclease P activity
LP475_RS08585	COG0230	Belongs to the bacterial ribosomal protein bL34 family