locus-tag	class	description
GTO86_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTO86_RS00010	COG0592	DNA-directed DNA polymerase activity
GTO86_RS00015	COG2501	S4 domain
GTO86_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTO86_RS00025	COG0187	DNA topoisomerase II activity
GTO86_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
GTO86_RS00040	COG0629	single-stranded DNA binding
GTO86_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTO86_RS00060	COG2390	Transcriptional regulator
GTO86_RS00070	COG0359	binds to the 23S rRNA
GTO86_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
GTO86_RS00080	COG2814	Major facilitator Superfamily
GTO86_RS00090	COG2326	polyphosphate kinase activity
GTO86_RS00110	COG1132	(ABC) transporter
GTO86_RS00120	COG0745	RESPONSE REGULATOR receiver
GTO86_RS00135	COG4853	Protein conserved in bacteria
GTO86_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GTO86_RS00145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTO86_RS00150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTO86_RS00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTO86_RS00180	COG4975	Glucose uptake
GTO86_RS00195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTO86_RS00200	COG1012	belongs to the aldehyde dehydrogenase family
GTO86_RS00210	COG1136	(ABC) transporter
GTO86_RS00215	COG0577	efflux transmembrane transporter activity
GTO86_RS00265	COG0436	Aminotransferase
GTO86_RS00290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTO86_RS00295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GTO86_RS00300	COG1074	ATP-dependent DNA helicase activity
GTO86_RS00305	COG1609	Transcriptional regulator
GTO86_RS00310	COG0183	Belongs to the thiolase family
GTO86_RS00320	COG1554	hydrolase, family 65, central catalytic
GTO86_RS00325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTO86_RS00335	COG2357	RelA SpoT domain protein
GTO86_RS00340	COG0745	RESPONSE REGULATOR receiver
GTO86_RS00345	COG5002	protein histidine kinase activity
GTO86_RS00360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GTO86_RS00365	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS00380	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTO86_RS00390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GTO86_RS00445	COG0366	Alpha amylase catalytic
GTO86_RS00460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTO86_RS00465	COG0505	Belongs to the CarA family
GTO86_RS00475	COG1609	Transcriptional regulator
GTO86_RS00480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTO86_RS00485	COG1053	succinate dehydrogenase
GTO86_RS00485	COG0431	NADPH-dependent FMN reductase
GTO86_RS00485	COG3976	FMN-binding domain protein
GTO86_RS00490	COG0431	NADPH-dependent FMN reductase
GTO86_RS00510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTO86_RS00515	COG0765	amino acid transport
GTO86_RS00525	COG1113	amino acid transport
GTO86_RS00535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTO86_RS00545	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTO86_RS00550	COG0357	Ribosomal RNA small subunit methyltransferase G
GTO86_RS00555	COG1475	DNA binding
GTO86_RS00560	COG1192	Involved in chromosome partitioning
GTO86_RS00565	COG1475	DNA binding
GTO86_RS00575	COG0012	GTP binding
GTO86_RS00585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTO86_RS00590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTO86_RS00595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GTO86_RS00600	COG0813	purine-nucleoside phosphorylase activity
GTO86_RS00605	COG2390	Transcriptional regulator
GTO86_RS00610	COG0517	IMP dehydrogenase activity
GTO86_RS00610	COG0516	GMP reductase activity
GTO86_RS00615	COG0745	RESPONSE REGULATOR receiver
GTO86_RS00640	COG0540	Belongs to the ATCase OTCase family
GTO86_RS00650	COG0167	dihydroorotate dehydrogenase activity
GTO86_RS00655	COG0284	orotidine-5'-phosphate decarboxylase activity
GTO86_RS00660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTO86_RS00670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTO86_RS00670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTO86_RS00675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTO86_RS00685	COG0628	permease
GTO86_RS00690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GTO86_RS00695	COG0028	Belongs to the TPP enzyme family
GTO86_RS00700	COG3527	Alpha-acetolactate decarboxylase
GTO86_RS00725	COG0083	homoserine kinase activity
GTO86_RS00730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTO86_RS00735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTO86_RS00740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTO86_RS00745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTO86_RS00750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTO86_RS00755	COG0047	phosphoribosylformylglycinamidine synthase activity
GTO86_RS00760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTO86_RS00770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTO86_RS00775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTO86_RS00780	COG0138	bifunctional purine biosynthesis protein purh
GTO86_RS00785	COG0151	Belongs to the GarS family
GTO86_RS00790	COG0588	phosphoglycerate mutase activity
GTO86_RS00800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTO86_RS00845	COG1476	TRANSCRIPTIONal
GTO86_RS00900	COG0789	Transcriptional regulator
GTO86_RS00915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTO86_RS00920	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO86_RS00925	COG0315	cyclic pyranopterin monophosphate synthase activity
GTO86_RS00965	COG0477	Major facilitator Superfamily
GTO86_RS00990	COG1757	Na H antiporter
GTO86_RS01010	COG0149	triose-phosphate isomerase activity
GTO86_RS01020	COG4989	oxidoreductase activity
GTO86_RS01035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTO86_RS01060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTO86_RS01070	COG1959	2 iron, 2 sulfur cluster binding
GTO86_RS01080	COG1174	glycine betaine transport
GTO86_RS01085	COG1125	glycine betaine transport
GTO86_RS01085	COG0517	IMP dehydrogenase activity
GTO86_RS01130	COG2814	Major facilitator Superfamily
GTO86_RS01135	COG1053	succinate dehydrogenase
GTO86_RS01135	COG3976	FMN-binding domain protein
GTO86_RS01140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTO86_RS01145	COG0531	amino acid
GTO86_RS01165	COG3973	AAA domain
GTO86_RS01185	COG0248	Ppx GppA phosphatase
GTO86_RS01200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTO86_RS01205	COG1801	Protein of unknown function DUF72
GTO86_RS01210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO86_RS01210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO86_RS01215	COG0084	hydrolase, TatD family'
GTO86_RS01220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GTO86_RS01225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTO86_RS01230	COG4466	Protein conserved in bacteria
GTO86_RS01235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTO86_RS01245	COG1121	(ABC) transporter
GTO86_RS01250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTO86_RS01255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO86_RS01260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTO86_RS01265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTO86_RS01285	COG1078	dGTPase activity
GTO86_RS01310	COG3343	RNA polymerase activity
GTO86_RS01315	COG0504	CTP synthase activity
GTO86_RS01320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTO86_RS01325	COG0254	rRNA binding
GTO86_RS01330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO86_RS01345	COG0574	Belongs to the PEP-utilizing enzyme family
GTO86_RS01345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GTO86_RS01355	COG0149	triose-phosphate isomerase activity
GTO86_RS01360	COG0191	fructose-bisphosphate aldolase activity
GTO86_RS01365	COG0406	alpha-ribazole phosphatase activity
GTO86_RS01370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTO86_RS01375	COG1704	LemA family
GTO86_RS01380	COG0501	Belongs to the peptidase M48B family
GTO86_RS01385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTO86_RS01405	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GTO86_RS01415	COG1696	Membrane protein involved in D-alanine export
GTO86_RS01420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTO86_RS01435	COG0736	holo-[acyl-carrier-protein] synthase activity
GTO86_RS01440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTO86_RS01445	COG2337	Toxic component of a toxin-antitoxin (TA) module
GTO86_RS01455	COG0402	S-adenosylhomocysteine deaminase activity
GTO86_RS01470	COG0193	aminoacyl-tRNA hydrolase activity
GTO86_RS01475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTO86_RS01480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTO86_RS01490	COG1098	S1 RNA binding domain
GTO86_RS01495	COG0037	tRNA processing
GTO86_RS01510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTO86_RS01515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTO86_RS01520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTO86_RS01525	COG2801	Transposase and inactivated derivatives
GTO86_RS01540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GTO86_RS01545	COG0765	amino acid transport
GTO86_RS01555	COG2188	Transcriptional regulator
GTO86_RS01565	COG2222	sugar isomerase
GTO86_RS01575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTO86_RS01650	COG0582	viral genome integration into host DNA
GTO86_RS01725	COG3104	oligopeptide transport
GTO86_RS01750	COG2814	Major facilitator Superfamily
GTO86_RS01760	COG1794	racemase activity, acting on amino acids and derivatives
GTO86_RS01765	COG2188	Transcriptional regulator
GTO86_RS01770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTO86_RS01775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTO86_RS01780	COG2183	response to ionizing radiation
GTO86_RS01785	COG3091	SprT-like family
GTO86_RS01795	COG3250	beta-galactosidase activity
GTO86_RS01800	COG3250	beta-galactosidase activity
GTO86_RS01810	COG0588	phosphoglycerate mutase activity
GTO86_RS01820	COG0626	cystathionine gamma-synthase activity
GTO86_RS01825	COG0765	amino acid transport
GTO86_RS01830	COG1126	abc transporter atp-binding protein
GTO86_RS01835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO86_RS01845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTO86_RS01855	COG0756	dUTP diphosphatase activity
GTO86_RS01860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTO86_RS01865	COG4956	integral membrane protein (PIN domain superfamily)
GTO86_RS01870	COG0215	cysteine-tRNA ligase activity
GTO86_RS01875	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GTO86_RS01880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTO86_RS01895	COG0250	Participates in transcription elongation, termination and antitermination
GTO86_RS01900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTO86_RS01910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTO86_RS01920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTO86_RS01925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTO86_RS01930	COG0222	ribosome binding
GTO86_RS01950	COG1970	mechanosensitive ion channel activity
GTO86_RS01955	COG1695	Transcriptional regulator
GTO86_RS01970	COG1012	belongs to the aldehyde dehydrogenase family
GTO86_RS01970	COG1454	alcohol dehydrogenase
GTO86_RS01980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTO86_RS01985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTO86_RS01990	COG0590	tRNA wobble adenosine to inosine editing
GTO86_RS02000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GTO86_RS02010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTO86_RS02020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTO86_RS02025	COG3870	Protein conserved in bacteria
GTO86_RS02030	COG0470	DNA polymerase III
GTO86_RS02035	COG4467	Involved in initiation control of chromosome replication
GTO86_RS02060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GTO86_RS02070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTO86_RS02075	COG1214	PFAM Peptidase M22, glycoprotease
GTO86_RS02085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTO86_RS02090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTO86_RS02095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTO86_RS02105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTO86_RS02110	COG0436	Aminotransferase
GTO86_RS02115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTO86_RS02120	COG0488	(ABC) transporter
GTO86_RS02125	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GTO86_RS02130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTO86_RS02135	COG0459	protein refolding
GTO86_RS02145	COG0531	amino acid
GTO86_RS02150	COG0531	amino acid
GTO86_RS02170	COG1739	Uncharacterized protein family UPF0029
GTO86_RS02175	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GTO86_RS02190	COG0653	protein targeting
GTO86_RS02195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GTO86_RS02200	COG1983	PspC domain protein
GTO86_RS02205	COG1950	PFAM Membrane protein of
GTO86_RS02210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GTO86_RS02215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTO86_RS02220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTO86_RS02225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTO86_RS02230	COG1556	Lactate utilization protein
GTO86_RS02235	COG1139	Iron-sulfur cluster binding protein
GTO86_RS02240	COG0247	lactate metabolic process
GTO86_RS02245	COG0492	ferredoxin-NADP+ reductase activity
GTO86_RS02255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO86_RS02260	COG1607	acyl-coa hydrolase
GTO86_RS02265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTO86_RS02280	COG0556	nucleotide-excision repair
GTO86_RS02285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTO86_RS02290	COG0531	amino acid
GTO86_RS02295	COG1660	Displays ATPase and GTPase activities
GTO86_RS02300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTO86_RS02305	COG1481	regulation of sporulation
GTO86_RS02315	COG0740	serine-type endopeptidase activity
GTO86_RS02335	COG0149	triose-phosphate isomerase activity
GTO86_RS02340	COG0148	phosphopyruvate hydratase activity
GTO86_RS02345	COG1113	amino acid transport
GTO86_RS02350	COG0038	chloride channel
GTO86_RS02365	COG0557	exoribonuclease II activity
GTO86_RS02370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTO86_RS02380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTO86_RS02385	COG0280	phosphate acetyltransferase
GTO86_RS02390	COG0802	atpase or kinase
GTO86_RS02405	COG2176	DNA-directed DNA polymerase activity
GTO86_RS02410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTO86_RS02420	COG1869	D-ribose catabolic process
GTO86_RS02425	COG0738	Major facilitator superfamily
GTO86_RS02440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTO86_RS02445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTO86_RS02455	COG2755	lipolytic protein G-D-S-L family
GTO86_RS02455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GTO86_RS02465	COG0561	phosphatase activity
GTO86_RS02480	COG0745	RESPONSE REGULATOR receiver
GTO86_RS02485	COG3850	Histidine kinase
GTO86_RS02485	COG5002	protein histidine kinase activity
GTO86_RS02490	COG4975	Glucose uptake
GTO86_RS02495	COG0110	maltose O-acetyltransferase activity
GTO86_RS02500	COG0166	Belongs to the GPI family
GTO86_RS02520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GTO86_RS02590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTO86_RS02595	COG2235	arginine
GTO86_RS02620	COG3442	glutamine amidotransferase
GTO86_RS02625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTO86_RS02630	COG1435	thymidine kinase activity
GTO86_RS02640	COG2890	protein-(glutamine-N5) methyltransferase activity
GTO86_RS02645	COG0009	L-threonylcarbamoyladenylate synthase
GTO86_RS02650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTO86_RS02655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTO86_RS02675	COG2233	PERMEase
GTO86_RS02680	COG0356	it plays a direct role in the translocation of protons across the membrane
GTO86_RS02685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTO86_RS02690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTO86_RS02695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTO86_RS02700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTO86_RS02705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTO86_RS02710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTO86_RS02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTO86_RS02725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTO86_RS02730	COG1077	Cell shape determining protein MreB Mrl
GTO86_RS02735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GTO86_RS02745	COG0772	Belongs to the SEDS family
GTO86_RS02755	COG1181	Belongs to the D-alanine--D-alanine ligase family
GTO86_RS02785	COG0589	response to stress
GTO86_RS02795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTO86_RS02820	COG3022	response to hydroperoxide
GTO86_RS02850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTO86_RS02855	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GTO86_RS02860	COG1104	cysteine desulfurase activity
GTO86_RS02865	COG0301	tRNA thio-modification
GTO86_RS02870	COG0525	valine-tRNA ligase activity
GTO86_RS02875	COG1271	oxidase subunit
GTO86_RS02880	COG1294	oxidase, subunit
GTO86_RS02885	COG4988	ABC transporter
GTO86_RS02890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTO86_RS02895	COG1252	NADH dehydrogenase
GTO86_RS02900	COG0285	dihydrofolate synthase activity
GTO86_RS02910	COG1077	Cell shape determining protein MreB Mrl
GTO86_RS02915	COG1792	Involved in formation and maintenance of cell shape
GTO86_RS02925	COG0765	amino acid transport
GTO86_RS02935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO86_RS02940	COG0612	Peptidase, M16
GTO86_RS02945	COG0612	Peptidase, M16
GTO86_RS02950	COG1426	Protein conserved in bacteria
GTO86_RS02955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTO86_RS02960	COG1058	Belongs to the CinA family
GTO86_RS02960	COG1546	Belongs to the CinA family
GTO86_RS02965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTO86_RS02975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTO86_RS02980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTO86_RS02985	COG0632	four-way junction helicase activity
GTO86_RS02990	COG2255	four-way junction helicase activity
GTO86_RS02995	COG0343	queuine tRNA-ribosyltransferase activity
GTO86_RS03000	COG1862	Preprotein translocase
GTO86_RS03005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTO86_RS03010	COG0513	Belongs to the DEAD box helicase family
GTO86_RS03015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTO86_RS03020	COG4472	Bacterial protein of unknown function (DUF965)
GTO86_RS03025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTO86_RS03030	COG3906	Belongs to the UPF0473 family
GTO86_RS03040	COG1193	negative regulation of DNA recombination
GTO86_RS03045	COG3118	belongs to the thioredoxin family
GTO86_RS03055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTO86_RS03060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTO86_RS03065	COG0622	Phosphoesterase
GTO86_RS03075	COG0561	phosphatase activity
GTO86_RS03080	COG0668	transmembrane transport
GTO86_RS03105	COG1609	Transcriptional regulator
GTO86_RS03115	COG0217	transcriptional regulatory protein
GTO86_RS03120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTO86_RS03125	COG1459	type II secretion system
GTO86_RS03130	COG4537	Required for transformation and DNA binding
GTO86_RS03150	COG0827	DNA restriction-modification system
GTO86_RS03155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTO86_RS03165	COG4470	Protein conserved in bacteria
GTO86_RS03170	COG0647	UMP catabolic process
GTO86_RS03180	COG0586	Pfam SNARE associated Golgi protein
GTO86_RS03330	COG4372	Transposase
GTO86_RS03360	COG1393	Belongs to the ArsC family
GTO86_RS03365	COG4862	establishment of competence for transformation
GTO86_RS03375	COG4690	dipeptidase activity
GTO86_RS03385	COG2357	RelA SpoT domain protein
GTO86_RS03390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTO86_RS03395	COG0564	pseudouridine synthase activity
GTO86_RS03435	COG4372	Transposase
GTO86_RS03445	COG2801	Transposase and inactivated derivatives
GTO86_RS03455	COG2706	6-phosphogluconolactonase activity
GTO86_RS03460	COG2226	methyltransferase
GTO86_RS03465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTO86_RS03470	COG1674	ftsk spoiiie
GTO86_RS03485	COG2001	Belongs to the MraZ family
GTO86_RS03490	COG0275	rRNA processing
GTO86_RS03500	COG0768	penicillin binding
GTO86_RS03505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTO86_RS03510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTO86_RS03515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTO86_RS03525	COG0849	cell division
GTO86_RS03530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTO86_RS03535	COG1799	cell septum assembly
GTO86_RS03545	COG2302	S4 RNA-binding domain
GTO86_RS03550	COG3599	regulation of cell shape
GTO86_RS03560	COG1278	Cold shock
GTO86_RS03565	COG0494	nUDIX hydrolase
GTO86_RS03575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTO86_RS03580	COG1104	cysteine desulfurase activity
GTO86_RS03590	COG0482	sulfurtransferase activity
GTO86_RS03595	COG0406	alpha-ribazole phosphatase activity
GTO86_RS03605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTO86_RS03610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTO86_RS03620	COG0527	aspartate kinase activity
GTO86_RS03625	COG0019	diaminopimelate decarboxylase activity
GTO86_RS03630	COG2171	N-acyltransferase activity
GTO86_RS03635	COG1473	amidohydrolase
GTO86_RS03640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTO86_RS03645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTO86_RS03650	COG0436	Aminotransferase
GTO86_RS03655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTO86_RS03660	COG3835	regulator
GTO86_RS03665	COG2610	gluconate transmembrane transporter activity
GTO86_RS03670	COG1929	Belongs to the glycerate kinase type-1 family
GTO86_RS03700	COG1597	lipid kinase activity
GTO86_RS03705	COG5503	Protein of unknown function (DUF1447)
GTO86_RS03715	COG0242	peptide deformylase activity
GTO86_RS03720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTO86_RS03745	COG0483	inositol monophosphate 1-phosphatase activity
GTO86_RS03750	COG1217	gtp-binding protein TYPA
GTO86_RS03755	COG0772	Belongs to the SEDS family
GTO86_RS03760	COG4471	UPF0298 protein
GTO86_RS03765	COG0742	ribosomal rna small subunit methyltransferase
GTO86_RS03770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTO86_RS03775	COG3480	Lon protease (S16) C-terminal proteolytic domain
GTO86_RS03780	COG1555	photosystem II stabilization
GTO86_RS03785	COG2131	deaminase
GTO86_RS03795	COG1466	dna polymerase III delta subunit
GTO86_RS03800	COG0268	Binds directly to 16S ribosomal RNA
GTO86_RS03805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTO86_RS03820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTO86_RS03825	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTO86_RS03830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTO86_RS03835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GTO86_RS03850	COG0322	excinuclease ABC activity
GTO86_RS03855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTO86_RS03860	COG1234	tRNA 3'-trailer cleavage
GTO86_RS03865	COG0300	oxidoreductase activity
GTO86_RS03870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GTO86_RS03870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTO86_RS03875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO86_RS03975	COG0328	RNA-DNA hybrid ribonuclease activity
GTO86_RS03980	COG3425	synthase
GTO86_RS03985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTO86_RS03990	COG4224	UPF0291 protein
GTO86_RS03995	COG3763	UPF0154 protein
GTO86_RS04000	COG0204	Acyl-transferase
GTO86_RS04005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GTO86_RS04010	COG2827	Endonuclease containing a URI domain
GTO86_RS04015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTO86_RS04020	COG0052	Belongs to the universal ribosomal protein uS2 family
GTO86_RS04025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTO86_RS04030	COG0528	UMP kinase activity
GTO86_RS04035	COG0233	cytoplasmic translational termination
GTO86_RS04040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTO86_RS04045	COG4589	Belongs to the CDS family
GTO86_RS04050	COG0750	zinc metalloprotease
GTO86_RS04055	COG0442	prolyl-tRNA aminoacylation
GTO86_RS04060	COG2176	DNA-directed DNA polymerase activity
GTO86_RS04065	COG0582	viral genome integration into host DNA
GTO86_RS04295	COG4632	Exopolysaccharide biosynthesis protein
GTO86_RS04295	COG5434	Belongs to the glycosyl hydrolase 28 family
GTO86_RS04325	COG0779	Required for maturation of 30S ribosomal subunits
GTO86_RS04330	COG0195	Participates in both transcription termination and antitermination
GTO86_RS04335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GTO86_RS04340	COG1358	cellular component organization or biogenesis
GTO86_RS04345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTO86_RS04350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTO86_RS04355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GTO86_RS04360	COG0196	riboflavin kinase activity
GTO86_RS04370	COG1420	regulation of RNA biosynthetic process
GTO86_RS04375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTO86_RS04380	COG0443	Heat shock 70 kDa protein
GTO86_RS04385	COG0484	heat shock protein binding
GTO86_RS04390	COG0481	GTPase activity
GTO86_RS04395	COG4974	Belongs to the 'phage' integrase family
GTO86_RS04435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTO86_RS04680	COG1388	LysM domain
GTO86_RS04680	COG3942	CHAP domain
GTO86_RS04700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GTO86_RS04710	COG0039	L-malate dehydrogenase activity
GTO86_RS04725	COG2264	protein methyltransferase activity
GTO86_RS04730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTO86_RS04740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTO86_RS04745	COG1490	D-aminoacyl-tRNA deacylase activity
GTO86_RS04750	COG3001	Fructosamine kinase
GTO86_RS04755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTO86_RS04760	COG1126	abc transporter atp-binding protein
GTO86_RS04765	COG0765	amino acid transport
GTO86_RS04770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTO86_RS04775	COG1610	YqeY-like protein
GTO86_RS04785	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GTO86_RS04790	COG0137	argininosuccinate synthase activity
GTO86_RS04795	COG0165	Argininosuccinate lyase
GTO86_RS04800	COG1268	BioY protein
GTO86_RS04805	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GTO86_RS04805	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GTO86_RS04810	COG1702	phosphate starvation-inducible protein PhoH
GTO86_RS04815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GTO86_RS04820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTO86_RS04825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTO86_RS04830	COG1381	Involved in DNA repair and RecF pathway recombination
GTO86_RS04835	COG0752	glycyl-tRNA synthetase alpha subunit
GTO86_RS04840	COG0751	glycine-tRNA ligase activity
GTO86_RS04845	COG0358	DNA primase activity
GTO86_RS04850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTO86_RS04855	COG0436	Aminotransferase
GTO86_RS04860	COG2384	SAM-dependent methyltransferase
GTO86_RS04865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTO86_RS04870	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTO86_RS04880	COG0587	DNA-directed DNA polymerase activity
GTO86_RS04890	COG2996	Protein conserved in bacteria
GTO86_RS04905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GTO86_RS04910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GTO86_RS04915	COG1187	pseudouridine synthase activity
GTO86_RS04920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GTO86_RS04930	COG0514	ATP-dependent DNA helicase (RecQ)
GTO86_RS04940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTO86_RS04945	COG0539	negative regulation of cytoplasmic translation
GTO86_RS04950	COG1160	GTP binding
GTO86_RS04955	COG0776	regulation of translation
GTO86_RS04965	COG0617	tRNA 3'-terminal CCA addition
GTO86_RS04970	COG0488	(ABC) transporter
GTO86_RS04975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GTO86_RS04980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTO86_RS04985	COG1272	protein, Hemolysin III
GTO86_RS04990	COG1307	EDD domain protein, DegV family
GTO86_RS05000	COG4698	Protein conserved in bacteria
GTO86_RS05005	COG4479	Belongs to the UPF0346 family
GTO86_RS05010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTO86_RS05015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTO86_RS05020	COG0758	DNA mediated transformation
GTO86_RS05025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTO86_RS05035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTO86_RS05040	COG0187	DNA topoisomerase II activity
GTO86_RS05055	COG1227	inorganic diphosphatase activity
GTO86_RS05070	COG1247	-acetyltransferase
GTO86_RS05090	COG1070	Carbohydrate kinase
GTO86_RS05095	COG1609	Transcriptional regulator
GTO86_RS05100	COG2610	gluconate transmembrane transporter activity
GTO86_RS05105	COG1070	Carbohydrate kinase
GTO86_RS05160	COG1957	nucleoside hydrolase
GTO86_RS05165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTO86_RS05175	COG2271	Major facilitator Superfamily
GTO86_RS05190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GTO86_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
GTO86_RS05215	COG0396	ATPase activity
GTO86_RS05220	COG0719	Fe-S assembly protein
GTO86_RS05225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTO86_RS05235	COG0719	Fe-S assembly protein
GTO86_RS05240	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO86_RS05250	COG2197	response regulator
GTO86_RS05260	COG0561	phosphatase activity
GTO86_RS05265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTO86_RS05265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GTO86_RS05285	COG1940	carbohydrate kinase activity
GTO86_RS05290	COG1609	Transcriptional regulator
GTO86_RS05330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTO86_RS05330	COG1199	ATP-dependent helicase activity
GTO86_RS05340	COG3935	DnaD domain protein
GTO86_RS05345	COG0697	spore germination
GTO86_RS05350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTO86_RS05355	COG3331	DNA recombination
GTO86_RS05360	COG4474	Belongs to the UPF0398 family
GTO86_RS05365	COG3599	regulation of cell shape
GTO86_RS05375	COG1780	Probably involved in ribonucleotide reductase function
GTO86_RS05385	COG0116	Belongs to the methyltransferase superfamily
GTO86_RS05390	COG0328	RNA-DNA hybrid ribonuclease activity
GTO86_RS05405	COG0564	pseudouridine synthase activity
GTO86_RS05410	COG0505	Belongs to the CarA family
GTO86_RS05415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTO86_RS05420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GTO86_RS05430	COG1307	EDD domain protein, DegV family
GTO86_RS05440	COG1418	mRNA catabolic process
GTO86_RS05460	COG2848	UPF0210 protein
GTO86_RS05465	COG3830	Belongs to the UPF0237 family
GTO86_RS05470	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS05475	COG0583	DNA-binding transcription factor activity
GTO86_RS05490	COG2707	UPF0756 membrane protein
GTO86_RS05495	COG2814	Major facilitator Superfamily
GTO86_RS05505	COG1253	flavin adenine dinucleotide binding
GTO86_RS05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTO86_RS05550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTO86_RS05560	COG1113	amino acid transport
GTO86_RS05605	COG0561	phosphatase activity
GTO86_RS05625	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
GTO86_RS05695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTO86_RS05700	COG0825	malonyl-CoA metabolic process
GTO86_RS05710	COG0439	Biotin carboxylase
GTO86_RS05725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTO86_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
GTO86_RS05740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTO86_RS05745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTO86_RS05750	COG1846	Transcriptional regulator
GTO86_RS05755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTO86_RS05780	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTO86_RS05830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GTO86_RS05835	COG0351	phosphomethylpyrimidine kinase
GTO86_RS05840	COG0352	thiamine-phosphate diphosphorylase activity
GTO86_RS05865	COG4372	Transposase
GTO86_RS05920	COG0363	glucosamine-6-phosphate deaminase activity
GTO86_RS05935	COG0737	Belongs to the 5'-nucleotidase family
GTO86_RS05950	COG0419	ATPase involved in DNA repair
GTO86_RS05960	COG4464	protein tyrosine phosphatase activity
GTO86_RS05990	COG0833	amino acid
GTO86_RS05995	COG2040	homocysteine
GTO86_RS06000	COG2801	Transposase and inactivated derivatives
GTO86_RS06005	COG5263	repeat protein
GTO86_RS06005	COG0366	Alpha amylase catalytic
GTO86_RS06035	COG0366	Alpha amylase catalytic
GTO86_RS06035	COG5263	repeat protein
GTO86_RS06050	COG1442	glycosyl transferase family 8
GTO86_RS06050	COG1216	Glycosyl transferase, family 2
GTO86_RS06055	COG1216	Glycosyl transferase, family 2
GTO86_RS06055	COG1442	glycosyl transferase family 8
GTO86_RS06060	COG1216	Glycosyl transferase, family 2
GTO86_RS06095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTO86_RS06100	COG0489	protein tyrosine kinase activity
GTO86_RS06130	COG1213	nucleotidyl transferase
GTO86_RS06140	COG3475	LICD family
GTO86_RS06150	COG1216	Glycosyl transferase, family 2
GTO86_RS06150	COG0463	Glycosyl transferase, family 2
GTO86_RS06165	COG1088	dTDP-glucose 4,6-dehydratase activity
GTO86_RS06175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GTO86_RS06180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTO86_RS06185	COG0489	protein tyrosine kinase activity
GTO86_RS06195	COG1316	TRANSCRIPTIONal
GTO86_RS06235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTO86_RS06240	COG1942	4-Oxalocrotonate Tautomerase
GTO86_RS06245	COG0569	domain protein
GTO86_RS06245	COG0475	glutathione-regulated potassium exporter activity
GTO86_RS06260	COG0450	alkyl hydroperoxide reductase
GTO86_RS06265	COG1760	l-serine dehydratase
GTO86_RS06270	COG1760	l-serine dehydratase
GTO86_RS06295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTO86_RS06310	COG2226	methyltransferase
GTO86_RS06345	COG1874	Beta-galactosidase
GTO86_RS06350	COG2211	Major facilitator Superfamily
GTO86_RS06350	COG2190	(PTS) system
GTO86_RS06355	COG1609	Transcriptional regulator
GTO86_RS06365	COG0708	Exodeoxyribonuclease III
GTO86_RS06385	COG4372	Transposase
GTO86_RS06505	COG3728	DNA packaging
GTO86_RS06505	COG5484	DNA packaging
GTO86_RS06710	COG0582	viral genome integration into host DNA
GTO86_RS06715	COG0335	large ribosomal subunit rRNA binding
GTO86_RS06720	COG0531	amino acid
GTO86_RS06725	COG0336	Belongs to the RNA methyltransferase TrmD family
GTO86_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTO86_RS06735	COG1837	Belongs to the UPF0109 family
GTO86_RS06740	COG0228	four-way junction DNA binding
GTO86_RS06745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTO86_RS06750	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GTO86_RS06755	COG0552	protein localization to endoplasmic reticulum
GTO86_RS06760	COG1196	nuclear chromosome segregation
GTO86_RS06765	COG0571	ribonuclease III activity
GTO86_RS06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTO86_RS06775	COG0416	fatty acid biosynthetic process
GTO86_RS06780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTO86_RS06790	COG1302	Protein conserved in bacteria
GTO86_RS06795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTO86_RS06800	COG1564	THIamine pyrophosphokinase
GTO86_RS06805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTO86_RS06810	COG1162	GTPase activity
GTO86_RS06815	COG0515	serine threonine protein kinase
GTO86_RS06815	COG2815	serine threonine protein kinase
GTO86_RS06820	COG0631	protein serine/threonine phosphatase activity
GTO86_RS06825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTO86_RS06825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTO86_RS06830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTO86_RS06835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTO86_RS06840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTO86_RS06845	COG1758	RNA polymerase activity
GTO86_RS06850	COG0194	GDP metabolic process
GTO86_RS06860	COG0497	DNA recombination
GTO86_RS06865	COG1438	arginine binding
GTO86_RS06870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GTO86_RS06880	COG1722	exodeoxyribonuclease VII activity
GTO86_RS06885	COG1570	exodeoxyribonuclease VII activity
GTO86_RS06890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTO86_RS06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTO86_RS06900	COG1302	Protein conserved in bacteria
GTO86_RS06910	COG0006	proline dipeptidase activity
GTO86_RS06915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTO86_RS06925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTO86_RS06935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTO86_RS06940	COG1309	transcriptional regulator
GTO86_RS06965	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO86_RS06970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTO86_RS06980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTO86_RS06990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTO86_RS07000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTO86_RS07005	COG1940	carbohydrate kinase activity
GTO86_RS07020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTO86_RS07025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTO86_RS07030	COG0768	penicillin binding
GTO86_RS07045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTO86_RS07050	COG0572	uridine kinase
GTO86_RS07060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO86_RS07060	COG0072	phenylalanine-tRNA ligase activity
GTO86_RS07065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTO86_RS07070	COG1733	regulation of RNA biosynthetic process
GTO86_RS07080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTO86_RS07085	COG1254	Belongs to the acylphosphatase family
GTO86_RS07090	COG0706	membrane insertase activity
GTO86_RS07095	COG0242	peptide deformylase activity
GTO86_RS07110	COG5002	protein histidine kinase activity
GTO86_RS07115	COG0745	RESPONSE REGULATOR receiver
GTO86_RS07120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTO86_RS07130	COG1323	Belongs to the UPF0348 family
GTO86_RS07135	COG2226	methyltransferase
GTO86_RS07140	COG0799	negative regulation of ribosome biogenesis
GTO86_RS07145	COG1713	HD superfamily hydrolase involved in NAD metabolism
GTO86_RS07150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTO86_RS07155	COG1534	Rna-binding protein
GTO86_RS07160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTO86_RS07165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GTO86_RS07180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTO86_RS07185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTO86_RS07190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GTO86_RS07195	COG1484	DNA-dependent DNA replication
GTO86_RS07205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTO86_RS07210	COG0237	dephospho-CoA kinase activity
GTO86_RS07215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTO86_RS07220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO86_RS07220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO86_RS07235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTO86_RS07245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTO86_RS07270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GTO86_RS07275	COG4473	ABC transporter
GTO86_RS07280	COG1131	(ABC) transporter
GTO86_RS07285	COG0537	adenosine 5'-monophosphoramidase activity
GTO86_RS07300	COG4717	serine-type aminopeptidase activity
GTO86_RS07305	COG0420	3'-5' exonuclease activity
GTO86_RS07310	COG3679	Belongs to the UPF0342 family
GTO86_RS07315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTO86_RS07320	COG0018	arginyl-trna synthetase
GTO86_RS07325	COG0351	phosphomethylpyrimidine kinase
GTO86_RS07330	COG0039	L-malate dehydrogenase activity
GTO86_RS07350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTO86_RS07355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTO86_RS07360	COG0285	dihydrofolate synthase activity
GTO86_RS07365	COG0302	gtp cyclohydrolase
GTO86_RS07370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTO86_RS07370	COG0302	gtp cyclohydrolase
GTO86_RS07375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTO86_RS07505	COG1428	Deoxynucleoside kinase
GTO86_RS07510	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO86_RS07510	COG1388	LysM domain
GTO86_RS07515	COG0589	response to stress
GTO86_RS07520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTO86_RS07525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTO86_RS07530	COG2244	polysaccharide biosynthetic process
GTO86_RS07540	COG0495	leucyl-tRNA aminoacylation
GTO86_RS07545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTO86_RS07550	COG2818	Glycosylase
GTO86_RS07555	COG2814	Major facilitator Superfamily
GTO86_RS07565	COG1113	amino acid transport
GTO86_RS07590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTO86_RS07595	COG0071	Belongs to the small heat shock protein (HSP20) family
GTO86_RS07600	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS07605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GTO86_RS07605	COG0167	dihydroorotate dehydrogenase activity
GTO86_RS07610	COG0493	'glutamate synthase
GTO86_RS07615	COG0708	Exodeoxyribonuclease III
GTO86_RS07640	COG0602	queuosine metabolic process
GTO86_RS07650	COG0477	Major facilitator Superfamily
GTO86_RS07755	COG0438	transferase activity, transferring glycosyl groups
GTO86_RS07760	COG0438	transferase activity, transferring glycosyl groups
GTO86_RS07765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GTO86_RS07770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTO86_RS07780	COG0542	response to heat
GTO86_RS07800	COG1131	(ABC) transporter
GTO86_RS07805	COG1725	Transcriptional regulator
GTO86_RS07815	COG0791	NLP P60 protein
GTO86_RS07815	COG3883	PFAM NLP P60 protein
GTO86_RS07820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GTO86_RS07825	COG1316	TRANSCRIPTIONal
GTO86_RS07830	COG0628	permease
GTO86_RS07840	COG1091	dTDP-4-dehydrorhamnose reductase activity
GTO86_RS07845	COG1088	dTDP-glucose 4,6-dehydratase activity
GTO86_RS07855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GTO86_RS07860	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO86_RS07885	COG1216	Glycosyl transferase, family 2
GTO86_RS07910	COG0438	transferase activity, transferring glycosyl groups
GTO86_RS07920	COG0562	UDP-galactopyranose mutase
GTO86_RS07945	COG0463	Glycosyl transferase, family 2
GTO86_RS07955	COG2137	regulation of response to DNA damage stimulus
GTO86_RS07970	COG1295	ribonuclease BN
GTO86_RS07985	COG0436	Aminotransferase
GTO86_RS07990	COG0024	Methionine aminopeptidase
GTO86_RS07995	COG0716	FMN binding
GTO86_RS08000	COG2246	polysaccharide biosynthetic process
GTO86_RS08010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTO86_RS08025	COG0673	inositol 2-dehydrogenase activity
GTO86_RS08075	COG0454	-acetyltransferase
GTO86_RS08100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTO86_RS08115	COG0456	acetyltransferase
GTO86_RS08120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTO86_RS08125	COG0004	ammonium transporteR
GTO86_RS08140	COG1335	isochorismatase
GTO86_RS08145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTO86_RS08155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTO86_RS08215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTO86_RS08225	COG2217	Heavy metal translocating P-type atpase
GTO86_RS08260	COG0494	nUDIX hydrolase
GTO86_RS08285	COG4974	Belongs to the 'phage' integrase family
GTO86_RS08350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO86_RS08350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO86_RS08405	COG4626	Terminase
GTO86_RS08405	COG1802	Transcriptional regulator
GTO86_RS08420	COG4695	Portal protein
GTO86_RS08480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTO86_RS08485	COG1597	lipid kinase activity
GTO86_RS08490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTO86_RS08495	COG0154	amidase activity
GTO86_RS08500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTO86_RS08505	COG4851	CamS sex pheromone cAM373 precursor
GTO86_RS08510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTO86_RS08525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO86_RS08530	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO86_RS08540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTO86_RS08545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTO86_RS08550	COG0101	tRNA pseudouridine synthase activity
GTO86_RS08570	COG0203	ribosomal protein L17
GTO86_RS08575	COG0202	RNA polymerase activity
GTO86_RS08580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTO86_RS08585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTO86_RS08590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTO86_RS08595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTO86_RS08610	COG0200	Binds to the 23S rRNA
GTO86_RS08615	COG1841	ribosomal large subunit assembly
GTO86_RS08620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTO86_RS08625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTO86_RS08630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GTO86_RS08635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTO86_RS08640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTO86_RS08645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTO86_RS08650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GTO86_RS08655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTO86_RS08665	COG0255	Belongs to the universal ribosomal protein uL29 family
GTO86_RS08670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTO86_RS08675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTO86_RS08680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTO86_RS08685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTO86_RS08690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTO86_RS08695	COG0089	rRNA binding
GTO86_RS08700	COG0088	Forms part of the polypeptide exit tunnel
GTO86_RS08705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTO86_RS08710	COG0051	transcription antitermination factor activity, RNA binding
GTO86_RS08725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTO86_RS08730	COG0049	tRNA binding
GTO86_RS08735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GTO86_RS08750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTO86_RS08755	COG0085	RNA polymerase activity
GTO86_RS08765	COG0542	response to heat
GTO86_RS08770	COG4463	regulation of RNA biosynthetic process
GTO86_RS08775	COG1064	alcohol dehydrogenase
GTO86_RS08815	COG1428	Deoxynucleoside kinase
GTO86_RS08820	COG0833	amino acid
GTO86_RS08845	COG1278	Cold shock
GTO86_RS08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO86_RS08885	COG0765	amino acid transport
GTO86_RS08890	COG0765	amino acid transport
GTO86_RS08915	COG2814	Major facilitator Superfamily
GTO86_RS08925	COG0564	pseudouridine synthase activity
GTO86_RS08935	COG0392	lysyltransferase activity
GTO86_RS08935	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GTO86_RS08940	COG0693	protein deglycase activity
GTO86_RS08950	COG0477	Major facilitator Superfamily
GTO86_RS08965	COG0583	DNA-binding transcription factor activity
GTO86_RS08970	COG0471	metal ion transport
GTO86_RS08975	COG1053	succinate dehydrogenase
GTO86_RS08980	COG0114	fumarate hydratase activity
GTO86_RS08985	COG0281	malic enzyme
GTO86_RS08990	COG0583	DNA-binding transcription factor activity
GTO86_RS09030	COG2017	converts alpha-aldose to the beta-anomer
GTO86_RS09045	COG1686	Belongs to the peptidase S11 family
GTO86_RS09065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTO86_RS09070	COG1288	antiporter activity
GTO86_RS09090	COG0488	(ABC) transporter
GTO86_RS09100	COG2855	membrane
GTO86_RS09110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTO86_RS09115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GTO86_RS09120	COG1914	H( )-stimulated, divalent metal cation uptake system
GTO86_RS09130	COG0569	domain protein
GTO86_RS09135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTO86_RS09145	COG0778	Nitroreductase
GTO86_RS09155	COG1215	transferase activity, transferring glycosyl groups
GTO86_RS09165	COG0704	Plays a role in the regulation of phosphate uptake
GTO86_RS09170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTO86_RS09175	COG0581	inorganic phosphate transmembrane transporter activity
GTO86_RS09180	COG0573	inorganic phosphate transmembrane transporter activity
GTO86_RS09190	COG0745	RESPONSE REGULATOR receiver
GTO86_RS09235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTO86_RS09260	COG1464	Belongs to the NlpA lipoprotein family
GTO86_RS09305	COG2801	Transposase and inactivated derivatives
GTO86_RS09360	COG2223	nitrite transmembrane transporter activity
GTO86_RS09380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GTO86_RS09385	COG2252	PERMEase
GTO86_RS09390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTO86_RS09405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTO86_RS09410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTO86_RS09415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTO86_RS09430	COG2153	protein acetylation
GTO86_RS09440	COG1733	regulation of RNA biosynthetic process
GTO86_RS09450	COG1733	regulation of RNA biosynthetic process
GTO86_RS09480	COG2826	transposase and inactivated derivatives, IS30 family
GTO86_RS09495	COG4974	Belongs to the 'phage' integrase family
GTO86_RS09560	COG0519	Catalyzes the synthesis of GMP from XMP
GTO86_RS09570	COG1072	(Pantothenic acid kinase))
GTO86_RS09575	COG1368	sulfuric ester hydrolase activity
GTO86_RS09585	COG2801	Transposase and inactivated derivatives
GTO86_RS09590	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTO86_RS09595	COG3973	AAA domain
GTO86_RS09600	COG0586	Pfam SNARE associated Golgi protein
GTO86_RS09610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTO86_RS09615	COG2261	transglycosylase associated protein
GTO86_RS09625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTO86_RS09630	COG1511	domain protein
GTO86_RS09655	COG0735	belongs to the Fur family
GTO86_RS09660	COG0194	GDP metabolic process
GTO86_RS09670	COG0531	amino acid
GTO86_RS09675	COG0477	Major facilitator Superfamily
GTO86_RS09720	COG1177	transmembrane transport
GTO86_RS09730	COG3842	ATPase activity
GTO86_RS09745	COG2936	dipeptidyl-peptidase activity
GTO86_RS09750	COG2267	carboxylic ester hydrolase activity
GTO86_RS09760	COG0783	Belongs to the Dps family
GTO86_RS09795	COG0492	ferredoxin-NADP+ reductase activity
GTO86_RS09820	COG1028	Short-chain dehydrogenase reductase Sdr
GTO86_RS09840	COG1122	ATPase activity
GTO86_RS09860	COG3759	membrane
GTO86_RS09870	COG1396	sequence-specific DNA binding
GTO86_RS09885	COG3775	system Galactitol-specific IIC component
GTO86_RS09890	COG2814	Major facilitator Superfamily
GTO86_RS09895	COG1131	(ABC) transporter
GTO86_RS09915	COG0095	Lipoate-protein ligase
GTO86_RS09920	COG0589	response to stress
GTO86_RS09930	COG1940	carbohydrate kinase activity
GTO86_RS09935	COG1114	Component of the transport system for branched-chain amino acids
GTO86_RS09955	COG2188	Transcriptional regulator
GTO86_RS09960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTO86_RS09975	COG1132	(ABC) transporter
GTO86_RS09990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTO86_RS10030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GTO86_RS10040	COG0406	alpha-ribazole phosphatase activity
GTO86_RS10045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GTO86_RS10050	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GTO86_RS10055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTO86_RS10060	COG0113	porphobilinogen synthase activity
GTO86_RS10065	COG0181	hydroxymethylbilane synthase activity
GTO86_RS10070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTO86_RS10075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTO86_RS10075	COG1648	precorrin-2 dehydrogenase activity
GTO86_RS10080	COG1492	cobalamin metabolic process
GTO86_RS10085	COG1122	ATPase activity
GTO86_RS10095	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GTO86_RS10100	COG0310	cobalt ion transport
GTO86_RS10115	COG1587	Uroporphyrinogen-III synthase
GTO86_RS10115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTO86_RS10150	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GTO86_RS10160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GTO86_RS10165	COG1797	cobyrinic acid a,c-diamide synthase activity
GTO86_RS10170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTO86_RS10175	COG2096	Adenosyltransferase
GTO86_RS10180	COG0431	NADPH-dependent FMN reductase
GTO86_RS10185	COG0716	FMN binding
GTO86_RS10190	COG0481	GTPase activity
GTO86_RS10205	COG2365	Tyrosine phosphatase family
GTO86_RS10215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTO86_RS10240	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GTO86_RS10250	COG4869	propanediol catabolic process
GTO86_RS10305	COG0849	cell division
GTO86_RS10310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTO86_RS10325	COG0628	permease
GTO86_RS10335	COG1846	Transcriptional regulator
GTO86_RS10355	COG1253	flavin adenine dinucleotide binding
GTO86_RS10370	COG2807	transmembrane transport
GTO86_RS10380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTO86_RS10390	COG2190	(PTS) system
GTO86_RS10390	COG2211	Major facilitator Superfamily
GTO86_RS10435	COG0586	Pfam SNARE associated Golgi protein
GTO86_RS10440	COG1609	Transcriptional regulator
GTO86_RS10445	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GTO86_RS10450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTO86_RS10460	COG2365	Tyrosine phosphatase family
GTO86_RS10465	COG1881	PFAM PEBP family protein
GTO86_RS10485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTO86_RS10495	COG2801	Transposase and inactivated derivatives
GTO86_RS10500	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS10505	COG0745	RESPONSE REGULATOR receiver
GTO86_RS10510	COG2205	protein histidine kinase activity
GTO86_RS10515	COG1136	(ABC) transporter
GTO86_RS10520	COG0577	efflux transmembrane transporter activity
GTO86_RS10530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTO86_RS10540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTO86_RS10545	COG2814	Major facilitator Superfamily
GTO86_RS10550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GTO86_RS10555	COG3620	sequence-specific DNA binding
GTO86_RS10560	COG3590	peptidase
GTO86_RS10580	COG2094	Belongs to the DNA glycosylase MPG family
GTO86_RS10585	COG3189	MarR family transcriptional regulator
GTO86_RS10595	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTO86_RS10620	COG2404	hydrolase activity, acting on ester bonds
GTO86_RS10630	COG1114	Component of the transport system for branched-chain amino acids
GTO86_RS10645	COG0488	(ABC) transporter
GTO86_RS10665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTO86_RS10675	COG0798	PFAM Bile acid sodium symporter
GTO86_RS10680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTO86_RS10695	COG3620	sequence-specific DNA binding
GTO86_RS10730	COG4120	Belongs to the binding-protein-dependent transport system permease family
GTO86_RS10745	COG0640	Transcriptional regulator
GTO86_RS10750	COG0534	Mate efflux family protein
GTO86_RS10755	COG3118	belongs to the thioredoxin family
GTO86_RS10760	COG0861	Integral membrane protein TerC family
GTO86_RS10765	COG0564	pseudouridine synthase activity
GTO86_RS10785	COG1757	Na H antiporter
GTO86_RS10790	COG1288	antiporter activity
GTO86_RS10805	COG0588	phosphoglycerate mutase activity
GTO86_RS10815	COG1368	sulfuric ester hydrolase activity
GTO86_RS10835	COG1686	Belongs to the peptidase S11 family
GTO86_RS10845	COG1376	ErfK ybiS ycfS ynhG family protein
GTO86_RS10870	COG2814	Major facilitator Superfamily
GTO86_RS10885	COG1609	Transcriptional regulator
GTO86_RS10890	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO86_RS10890	COG1388	LysM domain
GTO86_RS10900	COG0640	Transcriptional regulator
GTO86_RS10910	COG0577	efflux transmembrane transporter activity
GTO86_RS10910	COG1136	(ABC) transporter
GTO86_RS10915	COG1136	(ABC) transporter
GTO86_RS10935	COG1914	H( )-stimulated, divalent metal cation uptake system
GTO86_RS10940	COG2801	Transposase and inactivated derivatives
GTO86_RS10950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTO86_RS10965	COG0531	amino acid
GTO86_RS10975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTO86_RS10990	COG2153	protein acetylation
GTO86_RS11000	COG1733	regulation of RNA biosynthetic process
GTO86_RS11010	COG1733	regulation of RNA biosynthetic process
GTO86_RS11025	COG3579	cysteine-type endopeptidase activity
GTO86_RS11035	COG0308	aminopeptidase N
GTO86_RS11040	COG1959	2 iron, 2 sulfur cluster binding
GTO86_RS11050	COG2502	aspartate--ammonia ligase
GTO86_RS11055	COG0017	Asparaginyl-tRNA synthetase
GTO86_RS11070	COG3706	GGDEF domain
GTO86_RS11080	COG1215	transferase activity, transferring glycosyl groups
GTO86_RS11105	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS11110	COG0583	DNA-binding transcription factor activity
GTO86_RS11115	COG0252	asparaginase activity
GTO86_RS11125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTO86_RS11155	COG0583	DNA-binding transcription factor activity
GTO86_RS11170	COG0656	L-ascorbic acid biosynthetic process
GTO86_RS11175	COG3321	synthase
GTO86_RS11175	COG0604	alcohol dehydrogenase
GTO86_RS11180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTO86_RS11190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GTO86_RS11200	COG5002	protein histidine kinase activity
GTO86_RS11205	COG0745	RESPONSE REGULATOR receiver
GTO86_RS11210	COG1846	Transcriptional regulator
GTO86_RS11230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTO86_RS11235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GTO86_RS11250	COG1131	(ABC) transporter
GTO86_RS11260	COG1309	transcriptional regulator
GTO86_RS11270	COG1687	branched-chain amino acid
GTO86_RS11275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GTO86_RS11280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTO86_RS11335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTO86_RS11340	COG0367	asparagine synthase
GTO86_RS11345	COG0445	tRNA wobble uridine modification
GTO86_RS11350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTO86_RS11360	COG0706	membrane insertase activity
GTO86_RS11365	COG0594	ribonuclease P activity
GTO86_RS11370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GTO86_RS11375	COG1192	Involved in chromosome partitioning