locus-tag	class	description
LREU_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LREU_RS00010	COG0592	DNA-directed DNA polymerase activity
LREU_RS00015	COG2501	S4 domain
LREU_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LREU_RS00025	COG0187	DNA topoisomerase II activity
LREU_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LREU_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LREU_RS00040	COG0629	single-stranded DNA binding
LREU_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LREU_RS00055	COG0359	binds to the 23S rRNA
LREU_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LREU_RS00065	COG2814	Major facilitator Superfamily
LREU_RS00075	COG2326	polyphosphate kinase activity
LREU_RS00095	COG1132	(ABC) transporter
LREU_RS00105	COG0745	RESPONSE REGULATOR receiver
LREU_RS00120	COG4853	Protein conserved in bacteria
LREU_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LREU_RS00130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LREU_RS00135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LREU_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LREU_RS00165	COG4975	Glucose uptake
LREU_RS00175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LREU_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
LREU_RS00190	COG1136	(ABC) transporter
LREU_RS00195	COG0577	efflux transmembrane transporter activity
LREU_RS00225	COG0436	Aminotransferase
LREU_RS00250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LREU_RS00255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LREU_RS00260	COG1074	ATP-dependent DNA helicase activity
LREU_RS00265	COG1609	Transcriptional regulator
LREU_RS00270	COG0183	Belongs to the thiolase family
LREU_RS00280	COG1554	hydrolase, family 65, central catalytic
LREU_RS00285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LREU_RS00300	COG0745	RESPONSE REGULATOR receiver
LREU_RS00305	COG5002	protein histidine kinase activity
LREU_RS00325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LREU_RS00330	COG0656	L-ascorbic acid biosynthetic process
LREU_RS00345	COG0446	pyridine nucleotide-disulphide oxidoreductase
LREU_RS00355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LREU_RS00375	COG0675	Transposase, IS605 OrfB family
LREU_RS00385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LREU_RS00415	COG0438	transferase activity, transferring glycosyl groups
LREU_RS00425	COG0366	Alpha amylase catalytic
LREU_RS00435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LREU_RS00440	COG0505	Belongs to the CarA family
LREU_RS00450	COG1609	Transcriptional regulator
LREU_RS00455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LREU_RS00460	COG3976	FMN-binding domain protein
LREU_RS00460	COG1053	succinate dehydrogenase
LREU_RS00460	COG0431	NADPH-dependent FMN reductase
LREU_RS00465	COG0431	NADPH-dependent FMN reductase
LREU_RS00495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LREU_RS00500	COG0765	amino acid transport
LREU_RS00510	COG1113	amino acid transport
LREU_RS00515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LREU_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
LREU_RS00530	COG0357	Ribosomal RNA small subunit methyltransferase G
LREU_RS00535	COG1475	DNA binding
LREU_RS00540	COG1192	Involved in chromosome partitioning
LREU_RS00545	COG1475	DNA binding
LREU_RS00555	COG0012	GTP binding
LREU_RS00570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LREU_RS00575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LREU_RS00580	COG0813	purine-nucleoside phosphorylase activity
LREU_RS00585	COG2390	Transcriptional regulator
LREU_RS00590	COG0516	GMP reductase activity
LREU_RS00590	COG0517	IMP dehydrogenase activity
LREU_RS00595	COG0745	RESPONSE REGULATOR receiver
LREU_RS00600	COG5002	protein histidine kinase activity
LREU_RS00620	COG0540	Belongs to the ATCase OTCase family
LREU_RS00630	COG0167	dihydroorotate dehydrogenase activity
LREU_RS00635	COG0284	orotidine-5'-phosphate decarboxylase activity
LREU_RS00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LREU_RS00650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LREU_RS00655	COG0628	permease
LREU_RS00660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LREU_RS00665	COG0028	Belongs to the TPP enzyme family
LREU_RS00670	COG3527	Alpha-acetolactate decarboxylase
LREU_RS00675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LREU_RS00680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LREU_RS00685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LREU_RS00690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LREU_RS00695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LREU_RS00700	COG0047	phosphoribosylformylglycinamidine synthase activity
LREU_RS00705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LREU_RS00710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LREU_RS00715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LREU_RS00720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LREU_RS00725	COG0138	bifunctional purine biosynthesis protein purh
LREU_RS00730	COG0151	Belongs to the GarS family
LREU_RS00735	COG0588	phosphoglycerate mutase activity
LREU_RS00745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LREU_RS00800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LREU_RS00805	COG1335	isochorismatase
LREU_RS00810	COG1397	ADP-ribosylglycohydrolase
LREU_RS00820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LREU_RS00825	COG1733	regulation of RNA biosynthetic process
LREU_RS00830	COG0477	Major facilitator Superfamily
LREU_RS00855	COG1757	Na H antiporter
LREU_RS00865	COG3545	Serine hydrolase
LREU_RS00875	COG0149	triose-phosphate isomerase activity
LREU_RS00885	COG4989	oxidoreductase activity
LREU_RS00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LREU_RS00930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LREU_RS00940	COG1959	2 iron, 2 sulfur cluster binding
LREU_RS00950	COG1174	glycine betaine transport
LREU_RS00955	COG0517	IMP dehydrogenase activity
LREU_RS00955	COG1125	glycine betaine transport
LREU_RS01000	COG2814	Major facilitator Superfamily
LREU_RS01005	COG3976	FMN-binding domain protein
LREU_RS01005	COG1053	succinate dehydrogenase
LREU_RS01010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LREU_RS01015	COG0531	amino acid
LREU_RS01035	COG3973	AAA domain
LREU_RS01055	COG0248	Ppx GppA phosphatase
LREU_RS01070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LREU_RS01075	COG1801	Protein of unknown function DUF72
LREU_RS01080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LREU_RS01080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LREU_RS01085	COG0084	hydrolase, TatD family'
LREU_RS01090	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LREU_RS01095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LREU_RS01100	COG4466	Protein conserved in bacteria
LREU_RS01105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LREU_RS01115	COG1121	(ABC) transporter
LREU_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LREU_RS01125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LREU_RS01130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LREU_RS01135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LREU_RS01150	COG1078	dGTPase activity
LREU_RS01155	COG0095	Lipoate-protein ligase
LREU_RS01175	COG3343	RNA polymerase activity
LREU_RS01180	COG0504	CTP synthase activity
LREU_RS01190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LREU_RS01195	COG0254	rRNA binding
LREU_RS01200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LREU_RS01215	COG0149	triose-phosphate isomerase activity
LREU_RS01220	COG0191	fructose-bisphosphate aldolase activity
LREU_RS01225	COG0406	alpha-ribazole phosphatase activity
LREU_RS01230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LREU_RS01235	COG1704	LemA family
LREU_RS01240	COG0501	Belongs to the peptidase M48B family
LREU_RS01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LREU_RS01275	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LREU_RS01285	COG1696	Membrane protein involved in D-alanine export
LREU_RS01290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LREU_RS01300	COG0736	holo-[acyl-carrier-protein] synthase activity
LREU_RS01305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LREU_RS01310	COG2337	Toxic component of a toxin-antitoxin (TA) module
LREU_RS01320	COG0402	S-adenosylhomocysteine deaminase activity
LREU_RS01335	COG0193	aminoacyl-tRNA hydrolase activity
LREU_RS01340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LREU_RS01345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LREU_RS01355	COG1098	S1 RNA binding domain
LREU_RS01360	COG0037	tRNA processing
LREU_RS01375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LREU_RS01380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LREU_RS01385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LREU_RS01430	COG4372	Transposase
LREU_RS01445	COG3104	oligopeptide transport
LREU_RS01470	COG2814	Major facilitator Superfamily
LREU_RS01480	COG1794	racemase activity, acting on amino acids and derivatives
LREU_RS01485	COG2188	Transcriptional regulator
LREU_RS01490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LREU_RS01495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LREU_RS01500	COG2183	response to ionizing radiation
LREU_RS01505	COG3091	SprT-like family
LREU_RS01515	COG3250	beta-galactosidase activity
LREU_RS01520	COG3250	beta-galactosidase activity
LREU_RS01530	COG0588	phosphoglycerate mutase activity
LREU_RS01540	COG0626	cystathionine gamma-synthase activity
LREU_RS01545	COG0765	amino acid transport
LREU_RS01550	COG1126	abc transporter atp-binding protein
LREU_RS01555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LREU_RS01565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LREU_RS01575	COG0756	dUTP diphosphatase activity
LREU_RS01580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LREU_RS01585	COG4956	integral membrane protein (PIN domain superfamily)
LREU_RS01590	COG0215	cysteine-tRNA ligase activity
LREU_RS01595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LREU_RS01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LREU_RS01610	COG0250	Participates in transcription elongation, termination and antitermination
LREU_RS01615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LREU_RS01625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LREU_RS01630	COG1215	transferase activity, transferring glycosyl groups
LREU_RS01635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LREU_RS01640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LREU_RS01645	COG0222	ribosome binding
LREU_RS01660	COG1970	mechanosensitive ion channel activity
LREU_RS01665	COG1695	Transcriptional regulator
LREU_RS01680	COG1454	alcohol dehydrogenase
LREU_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
LREU_RS01690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LREU_RS01695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LREU_RS01700	COG0590	tRNA wobble adenosine to inosine editing
LREU_RS01705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LREU_RS01715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LREU_RS01725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LREU_RS01730	COG3870	Protein conserved in bacteria
LREU_RS01735	COG0470	DNA polymerase III
LREU_RS01740	COG4467	Involved in initiation control of chromosome replication
LREU_RS01760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LREU_RS01770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LREU_RS01785	COG1214	PFAM Peptidase M22, glycoprotease
LREU_RS01795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LREU_RS01800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LREU_RS01805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LREU_RS01815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LREU_RS01820	COG0436	Aminotransferase
LREU_RS01825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LREU_RS01835	COG0488	(ABC) transporter
LREU_RS01840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LREU_RS01850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LREU_RS01855	COG0459	protein refolding
LREU_RS01865	COG0531	amino acid
LREU_RS01870	COG0531	amino acid
LREU_RS01880	COG1846	Transcriptional regulator
LREU_RS01885	COG0477	Major facilitator Superfamily
LREU_RS01890	COG1739	Uncharacterized protein family UPF0029
LREU_RS01895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LREU_RS01910	COG0653	protein targeting
LREU_RS01915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LREU_RS01925	COG1950	PFAM Membrane protein of
LREU_RS01930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LREU_RS01935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LREU_RS01940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LREU_RS01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LREU_RS01950	COG1556	Lactate utilization protein
LREU_RS01955	COG1139	Iron-sulfur cluster binding protein
LREU_RS01960	COG0247	lactate metabolic process
LREU_RS01965	COG0492	ferredoxin-NADP+ reductase activity
LREU_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LREU_RS01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LREU_RS01980	COG1607	acyl-coa hydrolase
LREU_RS01985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LREU_RS02000	COG0556	nucleotide-excision repair
LREU_RS02005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LREU_RS02010	COG0531	amino acid
LREU_RS02015	COG1660	Displays ATPase and GTPase activities
LREU_RS02020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LREU_RS02025	COG1481	regulation of sporulation
LREU_RS02030	COG0740	serine-type endopeptidase activity
LREU_RS02035	COG1113	amino acid transport
LREU_RS02040	COG0038	chloride channel
LREU_RS02055	COG0557	exoribonuclease II activity
LREU_RS02060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LREU_RS02070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LREU_RS02075	COG0280	phosphate acetyltransferase
LREU_RS02080	COG0802	atpase or kinase
LREU_RS02095	COG2176	DNA-directed DNA polymerase activity
LREU_RS02100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LREU_RS02110	COG1869	D-ribose catabolic process
LREU_RS02115	COG0738	Major facilitator superfamily
LREU_RS02130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LREU_RS02135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LREU_RS02145	COG2755	lipolytic protein G-D-S-L family
LREU_RS02145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LREU_RS02155	COG0561	phosphatase activity
LREU_RS02165	COG0745	RESPONSE REGULATOR receiver
LREU_RS02170	COG5002	protein histidine kinase activity
LREU_RS02170	COG3850	Histidine kinase
LREU_RS02175	COG4975	Glucose uptake
LREU_RS02180	COG0110	maltose O-acetyltransferase activity
LREU_RS02185	COG0166	Belongs to the GPI family
LREU_RS02210	COG2201	protein-glutamate methylesterase activity
LREU_RS02215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LREU_RS02330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LREU_RS02335	COG2235	arginine
LREU_RS02360	COG3442	glutamine amidotransferase
LREU_RS02365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LREU_RS02370	COG1435	thymidine kinase activity
LREU_RS02380	COG2890	protein-(glutamine-N5) methyltransferase activity
LREU_RS02385	COG0009	L-threonylcarbamoyladenylate synthase
LREU_RS02390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LREU_RS02395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LREU_RS02415	COG2233	PERMEase
LREU_RS02420	COG0356	it plays a direct role in the translocation of protons across the membrane
LREU_RS02425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LREU_RS02430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LREU_RS02435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LREU_RS02440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LREU_RS02445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LREU_RS02450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LREU_RS02455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LREU_RS02465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LREU_RS02470	COG1077	Cell shape determining protein MreB Mrl
LREU_RS02480	COG0772	Belongs to the SEDS family
LREU_RS02495	COG1181	Belongs to the D-alanine--D-alanine ligase family
LREU_RS02515	COG0235	Class ii aldolase
LREU_RS02520	COG2160	L-arabinose isomerase activity
LREU_RS02525	COG0110	maltose O-acetyltransferase activity
LREU_RS02530	COG0656	L-ascorbic acid biosynthetic process
LREU_RS02535	COG1609	Transcriptional regulator
LREU_RS02540	COG0589	response to stress
LREU_RS02550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LREU_RS02575	COG3022	response to hydroperoxide
LREU_RS02580	COG0028	Belongs to the TPP enzyme family
LREU_RS02585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LREU_RS02605	COG2252	PERMEase
LREU_RS02610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LREU_RS02615	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LREU_RS02620	COG1104	cysteine desulfurase activity
LREU_RS02625	COG0301	tRNA thio-modification
LREU_RS02630	COG0525	valine-tRNA ligase activity
LREU_RS02635	COG1271	oxidase subunit
LREU_RS02640	COG1294	oxidase, subunit
LREU_RS02645	COG4988	ABC transporter
LREU_RS02650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LREU_RS02655	COG1252	NADH dehydrogenase
LREU_RS02660	COG0285	dihydrofolate synthase activity
LREU_RS02670	COG1077	Cell shape determining protein MreB Mrl
LREU_RS02675	COG1792	Involved in formation and maintenance of cell shape
LREU_RS02685	COG0765	amino acid transport
LREU_RS02695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LREU_RS02700	COG0612	Peptidase, M16
LREU_RS02705	COG0612	Peptidase, M16
LREU_RS02710	COG1426	Protein conserved in bacteria
LREU_RS02715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LREU_RS02720	COG1546	Belongs to the CinA family
LREU_RS02720	COG1058	Belongs to the CinA family
LREU_RS02725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LREU_RS02735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LREU_RS02740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LREU_RS02745	COG0632	four-way junction helicase activity
LREU_RS02750	COG2255	four-way junction helicase activity
LREU_RS02755	COG0343	queuine tRNA-ribosyltransferase activity
LREU_RS02760	COG1862	Preprotein translocase
LREU_RS02765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LREU_RS02770	COG0513	Belongs to the DEAD box helicase family
LREU_RS02775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LREU_RS02780	COG4472	Bacterial protein of unknown function (DUF965)
LREU_RS02785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LREU_RS02790	COG3906	Belongs to the UPF0473 family
LREU_RS02800	COG1193	negative regulation of DNA recombination
LREU_RS02805	COG3118	belongs to the thioredoxin family
LREU_RS02815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LREU_RS02820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LREU_RS02825	COG0622	Phosphoesterase
LREU_RS02835	COG0561	phosphatase activity
LREU_RS02840	COG0668	transmembrane transport
LREU_RS02860	COG1609	Transcriptional regulator
LREU_RS02870	COG0217	transcriptional regulatory protein
LREU_RS02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LREU_RS02880	COG1459	type II secretion system
LREU_RS02885	COG4537	Required for transformation and DNA binding
LREU_RS02905	COG0827	DNA restriction-modification system
LREU_RS02910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LREU_RS02920	COG4470	Protein conserved in bacteria
LREU_RS02925	COG0647	UMP catabolic process
LREU_RS02935	COG0586	Pfam SNARE associated Golgi protein
LREU_RS03065	COG1393	Belongs to the ArsC family
LREU_RS03070	COG4862	establishment of competence for transformation
LREU_RS03080	COG4690	dipeptidase activity
LREU_RS03090	COG2357	RelA SpoT domain protein
LREU_RS03095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LREU_RS03100	COG0564	pseudouridine synthase activity
LREU_RS03130	COG4372	Transposase
LREU_RS03150	COG2706	6-phosphogluconolactonase activity
LREU_RS03155	COG2226	methyltransferase
LREU_RS03160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LREU_RS03165	COG1674	ftsk spoiiie
LREU_RS03175	COG2001	Belongs to the MraZ family
LREU_RS03180	COG0275	rRNA processing
LREU_RS03190	COG0768	penicillin binding
LREU_RS03195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LREU_RS03200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LREU_RS03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LREU_RS03215	COG0849	cell division
LREU_RS03225	COG1799	cell septum assembly
LREU_RS03235	COG2302	S4 RNA-binding domain
LREU_RS03240	COG3599	regulation of cell shape
LREU_RS03250	COG1278	Cold shock
LREU_RS03255	COG0494	nUDIX hydrolase
LREU_RS03265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LREU_RS03270	COG1104	cysteine desulfurase activity
LREU_RS03280	COG0482	sulfurtransferase activity
LREU_RS03285	COG0406	alpha-ribazole phosphatase activity
LREU_RS03295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LREU_RS03300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LREU_RS03310	COG0527	aspartate kinase activity
LREU_RS03315	COG0019	diaminopimelate decarboxylase activity
LREU_RS03320	COG2171	N-acyltransferase activity
LREU_RS03325	COG1473	amidohydrolase
LREU_RS03330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LREU_RS03335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LREU_RS03340	COG0436	Aminotransferase
LREU_RS03345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LREU_RS03350	COG2508	Transcriptional regulator
LREU_RS03350	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LREU_RS03355	COG3835	regulator
LREU_RS03360	COG2610	gluconate transmembrane transporter activity
LREU_RS03365	COG1929	Belongs to the glycerate kinase type-1 family
LREU_RS03390	COG1597	lipid kinase activity
LREU_RS03395	COG5503	Protein of unknown function (DUF1447)
LREU_RS03405	COG0242	peptide deformylase activity
LREU_RS03410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LREU_RS03435	COG0483	inositol monophosphate 1-phosphatase activity
LREU_RS03440	COG1217	gtp-binding protein TYPA
LREU_RS03445	COG0772	Belongs to the SEDS family
LREU_RS03450	COG4471	UPF0298 protein
LREU_RS03455	COG0742	ribosomal rna small subunit methyltransferase
LREU_RS03460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LREU_RS03465	COG3480	Lon protease (S16) C-terminal proteolytic domain
LREU_RS03470	COG1555	photosystem II stabilization
LREU_RS03475	COG2131	deaminase
LREU_RS03480	COG0658	competence protein
LREU_RS03480	COG2333	competence protein COMEC
LREU_RS03485	COG1466	dna polymerase III delta subunit
LREU_RS03490	COG0268	Binds directly to 16S ribosomal RNA
LREU_RS03495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LREU_RS03510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LREU_RS03515	COG0544	peptidyl-prolyl cis-trans isomerase activity
LREU_RS03520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LREU_RS03525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LREU_RS03535	COG0322	excinuclease ABC activity
LREU_RS03540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LREU_RS03545	COG1234	tRNA 3'-trailer cleavage
LREU_RS03550	COG0300	oxidoreductase activity
LREU_RS03555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LREU_RS03555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LREU_RS03610	COG4695	Portal protein
LREU_RS03635	COG0328	RNA-DNA hybrid ribonuclease activity
LREU_RS03640	COG3425	synthase
LREU_RS03645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LREU_RS03650	COG4224	UPF0291 protein
LREU_RS03655	COG3763	UPF0154 protein
LREU_RS03660	COG0204	Acyl-transferase
LREU_RS03665	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LREU_RS03670	COG2827	Endonuclease containing a URI domain
LREU_RS03675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LREU_RS03680	COG0052	Belongs to the universal ribosomal protein uS2 family
LREU_RS03685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LREU_RS03690	COG0528	UMP kinase activity
LREU_RS03695	COG0233	cytoplasmic translational termination
LREU_RS03710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LREU_RS03715	COG4589	Belongs to the CDS family
LREU_RS03720	COG0750	zinc metalloprotease
LREU_RS03725	COG0442	prolyl-tRNA aminoacylation
LREU_RS03730	COG2176	DNA-directed DNA polymerase activity
LREU_RS03735	COG0779	Required for maturation of 30S ribosomal subunits
LREU_RS03740	COG0195	Participates in both transcription termination and antitermination
LREU_RS03745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LREU_RS03750	COG1358	cellular component organization or biogenesis
LREU_RS03755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LREU_RS03760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LREU_RS03765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LREU_RS03770	COG0196	riboflavin kinase activity
LREU_RS03780	COG1420	regulation of RNA biosynthetic process
LREU_RS03785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LREU_RS03790	COG0443	Heat shock 70 kDa protein
LREU_RS03795	COG0484	heat shock protein binding
LREU_RS03800	COG0481	GTPase activity
LREU_RS03805	COG4974	Belongs to the 'phage' integrase family
LREU_RS03830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LREU_RS03840	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LREU_RS03845	COG0039	L-malate dehydrogenase activity
LREU_RS03860	COG2264	protein methyltransferase activity
LREU_RS03865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LREU_RS03875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LREU_RS03880	COG1490	D-aminoacyl-tRNA deacylase activity
LREU_RS03885	COG3001	Fructosamine kinase
LREU_RS03890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LREU_RS03900	COG1126	abc transporter atp-binding protein
LREU_RS03905	COG0765	amino acid transport
LREU_RS03910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LREU_RS03915	COG1610	YqeY-like protein
LREU_RS03920	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LREU_RS03925	COG0137	argininosuccinate synthase activity
LREU_RS03930	COG0165	Argininosuccinate lyase
LREU_RS03935	COG1268	BioY protein
LREU_RS03940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LREU_RS03940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LREU_RS03945	COG1702	phosphate starvation-inducible protein PhoH
LREU_RS03950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LREU_RS03955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LREU_RS03960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LREU_RS03965	COG1381	Involved in DNA repair and RecF pathway recombination
LREU_RS03970	COG0752	glycyl-tRNA synthetase alpha subunit
LREU_RS03975	COG0751	glycine-tRNA ligase activity
LREU_RS03980	COG0358	DNA primase activity
LREU_RS03985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LREU_RS03990	COG0436	Aminotransferase
LREU_RS04000	COG2384	SAM-dependent methyltransferase
LREU_RS04005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LREU_RS04010	COG2195	Cleaves the N-terminal amino acid of tripeptides
LREU_RS04020	COG0587	DNA-directed DNA polymerase activity
LREU_RS04030	COG2996	Protein conserved in bacteria
LREU_RS04045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LREU_RS04050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LREU_RS04055	COG1187	pseudouridine synthase activity
LREU_RS04060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LREU_RS04070	COG0514	ATP-dependent DNA helicase (RecQ)
LREU_RS04080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LREU_RS04085	COG0539	negative regulation of cytoplasmic translation
LREU_RS04090	COG1160	GTP binding
LREU_RS04095	COG0776	regulation of translation
LREU_RS04105	COG0617	tRNA 3'-terminal CCA addition
LREU_RS04110	COG0488	(ABC) transporter
LREU_RS04115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LREU_RS04120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LREU_RS04125	COG1272	protein, Hemolysin III
LREU_RS04130	COG1307	EDD domain protein, DegV family
LREU_RS04140	COG4698	Protein conserved in bacteria
LREU_RS04145	COG4479	Belongs to the UPF0346 family
LREU_RS04150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LREU_RS04155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LREU_RS04160	COG0758	DNA mediated transformation
LREU_RS04165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LREU_RS04175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LREU_RS04180	COG0187	DNA topoisomerase II activity
LREU_RS04195	COG1227	inorganic diphosphatase activity
LREU_RS04220	COG1247	-acetyltransferase
LREU_RS04240	COG1070	Carbohydrate kinase
LREU_RS04245	COG1609	Transcriptional regulator
LREU_RS04250	COG2610	gluconate transmembrane transporter activity
LREU_RS04285	COG1396	sequence-specific DNA binding
LREU_RS04320	COG3723	Recombinational DNA repair protein, rece pathway
LREU_RS04485	COG5280	Phage tail tape measure protein TP901
LREU_RS04485	COG3953	SLT domain
LREU_RS04540	COG4824	toxin secretion phage lysis holin
LREU_RS04545	COG5263	repeat protein
LREU_RS04545	COG5632	N-Acetylmuramoyl-L-alanine amidase
LREU_RS04550	COG1070	Carbohydrate kinase
LREU_RS04570	COG0154	amidase activity
LREU_RS04585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LREU_RS04600	COG4974	Belongs to the 'phage' integrase family
LREU_RS04610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LREU_RS04625	COG1957	nucleoside hydrolase
LREU_RS04630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LREU_RS04630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LREU_RS04635	COG0307	riboflavin synthase, alpha
LREU_RS04640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LREU_RS04640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LREU_RS04645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LREU_RS04650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LREU_RS04660	COG2271	Major facilitator Superfamily
LREU_RS04675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LREU_RS04680	COG0318	PFAM AMP-dependent synthetase and ligase
LREU_RS04695	COG0396	ATPase activity
LREU_RS04700	COG0719	Fe-S assembly protein
LREU_RS04705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LREU_RS04715	COG0719	Fe-S assembly protein
LREU_RS04720	COG2151	metal-sulfur cluster biosynthetic enzyme
LREU_RS04730	COG2197	response regulator
LREU_RS04740	COG0561	phosphatase activity
LREU_RS04745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LREU_RS04745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LREU_RS04755	COG3275	phosphorelay sensor kinase activity
LREU_RS04770	COG1346	cytolysis
LREU_RS04785	COG1609	Transcriptional regulator
LREU_RS04800	COG1304	FMN binding
LREU_RS04820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LREU_RS04820	COG1199	ATP-dependent helicase activity
LREU_RS04830	COG3935	DnaD domain protein
LREU_RS04835	COG0697	spore germination
LREU_RS04840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LREU_RS04845	COG3331	DNA recombination
LREU_RS04850	COG4474	Belongs to the UPF0398 family
LREU_RS04855	COG3599	regulation of cell shape
LREU_RS04860	COG1780	Probably involved in ribonucleotide reductase function
LREU_RS04865	COG0116	Belongs to the methyltransferase superfamily
LREU_RS04870	COG0328	RNA-DNA hybrid ribonuclease activity
LREU_RS04885	COG0564	pseudouridine synthase activity
LREU_RS04890	COG0505	Belongs to the CarA family
LREU_RS04895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LREU_RS04900	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LREU_RS04905	COG1307	EDD domain protein, DegV family
LREU_RS04915	COG1418	mRNA catabolic process
LREU_RS04940	COG2848	UPF0210 protein
LREU_RS04945	COG3830	Belongs to the UPF0237 family
LREU_RS04950	COG0656	L-ascorbic acid biosynthetic process
LREU_RS04955	COG0583	DNA-binding transcription factor activity
LREU_RS04970	COG2707	UPF0756 membrane protein
LREU_RS04975	COG2814	Major facilitator Superfamily
LREU_RS04985	COG1253	flavin adenine dinucleotide binding
LREU_RS05015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LREU_RS05030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LREU_RS05040	COG1113	amino acid transport
LREU_RS05090	COG0561	phosphatase activity
LREU_RS05180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LREU_RS05195	COG0439	Biotin carboxylase
LREU_RS05210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LREU_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
LREU_RS05220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LREU_RS05225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LREU_RS05230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LREU_RS05235	COG1846	Transcriptional regulator
LREU_RS05240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LREU_RS05250	COG4974	Belongs to the 'phage' integrase family
LREU_RS05260	COG1752	Esterase of the alpha-beta hydrolase superfamily
LREU_RS05300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LREU_RS05315	COG4372	Transposase
LREU_RS05330	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LREU_RS05335	COG0351	phosphomethylpyrimidine kinase
LREU_RS05340	COG0352	thiamine-phosphate diphosphorylase activity
LREU_RS05410	COG0363	glucosamine-6-phosphate deaminase activity
LREU_RS05415	COG2184	nucleotidyltransferase activity
LREU_RS05425	COG0737	Belongs to the 5'-nucleotidase family
LREU_RS05435	COG0419	ATPase involved in DNA repair
LREU_RS05445	COG4464	protein tyrosine phosphatase activity
LREU_RS05450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LREU_RS05480	COG0833	amino acid
LREU_RS05485	COG2040	homocysteine
LREU_RS05520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LREU_RS05540	COG1091	dTDP-4-dehydrorhamnose reductase activity
LREU_RS05545	COG1088	dTDP-glucose 4,6-dehydratase activity
LREU_RS05555	COG1316	TRANSCRIPTIONal
LREU_RS05600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LREU_RS05605	COG1942	4-Oxalocrotonate Tautomerase
LREU_RS05610	COG0569	domain protein
LREU_RS05610	COG0475	glutathione-regulated potassium exporter activity
LREU_RS05635	COG0450	alkyl hydroperoxide reductase
LREU_RS05640	COG1760	l-serine dehydratase
LREU_RS05645	COG1760	l-serine dehydratase
LREU_RS05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LREU_RS05675	COG2226	methyltransferase
LREU_RS05680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LREU_RS05700	COG1874	Beta-galactosidase
LREU_RS05705	COG2190	(PTS) system
LREU_RS05705	COG2211	Major facilitator Superfamily
LREU_RS05710	COG1609	Transcriptional regulator
LREU_RS05725	COG0708	Exodeoxyribonuclease III
LREU_RS05745	COG5263	repeat protein
LREU_RS05745	COG5632	N-Acetylmuramoyl-L-alanine amidase
LREU_RS05800	COG0791	NLP P60 protein
LREU_RS05800	COG1388	LysM domain
LREU_RS06030	COG0582	viral genome integration into host DNA
LREU_RS06035	COG0335	large ribosomal subunit rRNA binding
LREU_RS06040	COG0531	amino acid
LREU_RS06045	COG0336	Belongs to the RNA methyltransferase TrmD family
LREU_RS06050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LREU_RS06055	COG1837	Belongs to the UPF0109 family
LREU_RS06060	COG0228	four-way junction DNA binding
LREU_RS06065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LREU_RS06070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LREU_RS06075	COG0552	protein localization to endoplasmic reticulum
LREU_RS06080	COG1196	nuclear chromosome segregation
LREU_RS06085	COG0571	ribonuclease III activity
LREU_RS06090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LREU_RS06095	COG0416	fatty acid biosynthetic process
LREU_RS06100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LREU_RS06110	COG1302	Protein conserved in bacteria
LREU_RS06115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LREU_RS06120	COG1564	THIamine pyrophosphokinase
LREU_RS06125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LREU_RS06130	COG1162	GTPase activity
LREU_RS06135	COG2815	serine threonine protein kinase
LREU_RS06135	COG0515	serine threonine protein kinase
LREU_RS06140	COG0631	protein serine/threonine phosphatase activity
LREU_RS06145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LREU_RS06145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LREU_RS06150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LREU_RS06155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LREU_RS06160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LREU_RS06165	COG1758	RNA polymerase activity
LREU_RS06170	COG0194	GDP metabolic process
LREU_RS06180	COG0497	DNA recombination
LREU_RS06185	COG1438	arginine binding
LREU_RS06190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LREU_RS06200	COG1722	exodeoxyribonuclease VII activity
LREU_RS06205	COG1570	exodeoxyribonuclease VII activity
LREU_RS06210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LREU_RS06215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LREU_RS06220	COG1302	Protein conserved in bacteria
LREU_RS06230	COG0006	proline dipeptidase activity
LREU_RS06235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LREU_RS06240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LREU_RS06250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LREU_RS06255	COG1309	transcriptional regulator
LREU_RS06280	COG2151	metal-sulfur cluster biosynthetic enzyme
LREU_RS06285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LREU_RS06290	COG1464	Belongs to the NlpA lipoprotein family
LREU_RS06295	COG0436	Aminotransferase
LREU_RS06300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LREU_RS06310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LREU_RS06320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LREU_RS06325	COG1940	carbohydrate kinase activity
LREU_RS06335	COG0457	Tetratricopeptide repeat
LREU_RS06335	COG0705	Rhomboid family
LREU_RS06340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LREU_RS06345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LREU_RS06350	COG0768	penicillin binding
LREU_RS06365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LREU_RS06370	COG0572	uridine kinase
LREU_RS06380	COG0072	phenylalanine-tRNA ligase activity
LREU_RS06380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LREU_RS06385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LREU_RS06390	COG1733	regulation of RNA biosynthetic process
LREU_RS06400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LREU_RS06405	COG1254	Belongs to the acylphosphatase family
LREU_RS06410	COG0706	membrane insertase activity
LREU_RS06415	COG0242	peptide deformylase activity
LREU_RS06430	COG5002	protein histidine kinase activity
LREU_RS06435	COG0745	RESPONSE REGULATOR receiver
LREU_RS06440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LREU_RS06450	COG1323	Belongs to the UPF0348 family
LREU_RS06460	COG0799	negative regulation of ribosome biogenesis
LREU_RS06465	COG1713	HD superfamily hydrolase involved in NAD metabolism
LREU_RS06470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LREU_RS06475	COG1534	Rna-binding protein
LREU_RS06480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LREU_RS06485	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LREU_RS06490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LREU_RS06495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LREU_RS06500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LREU_RS06505	COG1484	DNA-dependent DNA replication
LREU_RS06515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LREU_RS06520	COG0237	dephospho-CoA kinase activity
LREU_RS06525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LREU_RS06530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LREU_RS06530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LREU_RS06545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LREU_RS06555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LREU_RS06570	COG0667	Aldo Keto reductase
LREU_RS06575	COG0438	transferase activity, transferring glycosyl groups
LREU_RS06595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LREU_RS06600	COG4473	ABC transporter
LREU_RS06605	COG1131	(ABC) transporter
LREU_RS06610	COG0537	adenosine 5'-monophosphoramidase activity
LREU_RS06625	COG4717	serine-type aminopeptidase activity
LREU_RS06630	COG0420	3'-5' exonuclease activity
LREU_RS06635	COG3679	Belongs to the UPF0342 family
LREU_RS06640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LREU_RS06645	COG0018	arginyl-trna synthetase
LREU_RS06650	COG0351	phosphomethylpyrimidine kinase
LREU_RS06655	COG0039	L-malate dehydrogenase activity
LREU_RS06675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LREU_RS06680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LREU_RS06685	COG0285	dihydrofolate synthase activity
LREU_RS06690	COG0302	gtp cyclohydrolase
LREU_RS06695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LREU_RS06695	COG0302	gtp cyclohydrolase
LREU_RS06700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LREU_RS06745	COG1428	Deoxynucleoside kinase
LREU_RS06750	COG1388	LysM domain
LREU_RS06750	COG1705	Flagellar rod assembly protein muramidase FlgJ
LREU_RS06755	COG0589	response to stress
LREU_RS06760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LREU_RS06765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LREU_RS06770	COG2244	polysaccharide biosynthetic process
LREU_RS06780	COG0495	leucyl-tRNA aminoacylation
LREU_RS06785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LREU_RS06790	COG2818	Glycosylase
LREU_RS06800	COG2814	Major facilitator Superfamily
LREU_RS06810	COG1113	amino acid transport
LREU_RS06830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LREU_RS06835	COG0071	Belongs to the small heat shock protein (HSP20) family
LREU_RS06840	COG0656	L-ascorbic acid biosynthetic process
LREU_RS06845	COG0167	dihydroorotate dehydrogenase activity
LREU_RS06845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LREU_RS06850	COG0493	'glutamate synthase
LREU_RS06855	COG0708	Exodeoxyribonuclease III
LREU_RS06880	COG0602	queuosine metabolic process
LREU_RS06890	COG0477	Major facilitator Superfamily
LREU_RS06980	COG0438	transferase activity, transferring glycosyl groups
LREU_RS06985	COG0438	transferase activity, transferring glycosyl groups
LREU_RS06990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LREU_RS06995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LREU_RS07005	COG0542	response to heat
LREU_RS07025	COG1131	(ABC) transporter
LREU_RS07030	COG1725	Transcriptional regulator
LREU_RS07035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LREU_RS07040	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LREU_RS07055	COG2801	Transposase and inactivated derivatives
LREU_RS07100	COG3883	PFAM NLP P60 protein
LREU_RS07100	COG0791	NLP P60 protein
LREU_RS07115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LREU_RS07120	COG1316	TRANSCRIPTIONal
LREU_RS07130	COG0628	permease
LREU_RS07170	COG1442	glycosyl transferase family 8
LREU_RS07170	COG1216	Glycosyl transferase, family 2
LREU_RS07185	COG3266	domain, Protein
LREU_RS07185	COG5632	N-Acetylmuramoyl-L-alanine amidase
LREU_RS07185	COG4193	domain, Protein
LREU_RS07195	COG1705	Flagellar rod assembly protein muramidase FlgJ
LREU_RS07205	COG0438	transferase activity, transferring glycosyl groups
LREU_RS07210	COG0438	transferase activity, transferring glycosyl groups
LREU_RS07230	COG0562	UDP-galactopyranose mutase
LREU_RS07240	COG0463	Glycosyl transferase, family 2
LREU_RS07250	COG2137	regulation of response to DNA damage stimulus
LREU_RS07265	COG1295	ribonuclease BN
LREU_RS07280	COG0436	Aminotransferase
LREU_RS07285	COG0024	Methionine aminopeptidase
LREU_RS07290	COG0716	FMN binding
LREU_RS07295	COG2246	polysaccharide biosynthetic process
LREU_RS07305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LREU_RS07320	COG0673	inositol 2-dehydrogenase activity
LREU_RS07340	COG2918	glutathione biosynthetic process
LREU_RS07340	COG1181	Belongs to the D-alanine--D-alanine ligase family
LREU_RS07365	COG0454	-acetyltransferase
LREU_RS07390	COG0675	Transposase, IS605 OrfB family
LREU_RS07395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LREU_RS07410	COG0456	acetyltransferase
LREU_RS07420	COG0004	ammonium transporteR
LREU_RS07450	COG1131	(ABC) transporter
LREU_RS07470	COG3012	SEC-C Motif Domain Protein
LREU_RS07485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LREU_RS07495	COG2217	Heavy metal translocating P-type atpase
LREU_RS07520	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LREU_RS07530	COG4974	Belongs to the 'phage' integrase family
LREU_RS07540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LREU_RS07550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LREU_RS07555	COG1597	lipid kinase activity
LREU_RS07560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LREU_RS07565	COG0154	amidase activity
LREU_RS07570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LREU_RS07575	COG4851	CamS sex pheromone cAM373 precursor
LREU_RS07580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LREU_RS07595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LREU_RS07600	COG1705	Flagellar rod assembly protein muramidase FlgJ
LREU_RS07610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LREU_RS07615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LREU_RS07620	COG0101	tRNA pseudouridine synthase activity
LREU_RS07640	COG0203	ribosomal protein L17
LREU_RS07645	COG0202	RNA polymerase activity
LREU_RS07650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LREU_RS07655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LREU_RS07660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LREU_RS07665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LREU_RS07680	COG0200	Binds to the 23S rRNA
LREU_RS07685	COG1841	ribosomal large subunit assembly
LREU_RS07690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LREU_RS07695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LREU_RS07700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LREU_RS07705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LREU_RS07710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LREU_RS07715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LREU_RS07720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LREU_RS07725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LREU_RS07735	COG0255	Belongs to the universal ribosomal protein uL29 family
LREU_RS07740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LREU_RS07745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LREU_RS07750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LREU_RS07755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LREU_RS07760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LREU_RS07765	COG0089	rRNA binding
LREU_RS07770	COG0088	Forms part of the polypeptide exit tunnel
LREU_RS07775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LREU_RS07780	COG0051	transcription antitermination factor activity, RNA binding
LREU_RS07790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LREU_RS07795	COG0049	tRNA binding
LREU_RS07800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LREU_RS07815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LREU_RS07820	COG0085	RNA polymerase activity
LREU_RS07830	COG0542	response to heat
LREU_RS07835	COG4463	regulation of RNA biosynthetic process
LREU_RS07840	COG1064	alcohol dehydrogenase
LREU_RS07875	COG1428	Deoxynucleoside kinase
LREU_RS07885	COG0833	amino acid
LREU_RS07910	COG1278	Cold shock
LREU_RS07945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LREU_RS07950	COG0765	amino acid transport
LREU_RS07955	COG0765	amino acid transport
LREU_RS07980	COG2814	Major facilitator Superfamily
LREU_RS07990	COG0564	pseudouridine synthase activity
LREU_RS08000	COG0392	lysyltransferase activity
LREU_RS08000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LREU_RS08005	COG0693	protein deglycase activity
LREU_RS08015	COG2814	Major facilitator Superfamily
LREU_RS08030	COG0583	DNA-binding transcription factor activity
LREU_RS08035	COG0471	metal ion transport
LREU_RS08045	COG0114	fumarate hydratase activity
LREU_RS08050	COG0281	malic enzyme
LREU_RS08055	COG0583	DNA-binding transcription factor activity
LREU_RS08080	COG2017	converts alpha-aldose to the beta-anomer
LREU_RS08090	COG1686	Belongs to the peptidase S11 family
LREU_RS08110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LREU_RS08115	COG1288	antiporter activity
LREU_RS08145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LREU_RS08150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LREU_RS08155	COG1914	H( )-stimulated, divalent metal cation uptake system
LREU_RS08160	COG2226	methyltransferase
LREU_RS08165	COG0569	domain protein
LREU_RS08170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LREU_RS08180	COG0778	Nitroreductase
LREU_RS08190	COG1215	transferase activity, transferring glycosyl groups
LREU_RS08200	COG0704	Plays a role in the regulation of phosphate uptake
LREU_RS08205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LREU_RS08210	COG0581	inorganic phosphate transmembrane transporter activity
LREU_RS08215	COG0573	inorganic phosphate transmembrane transporter activity
LREU_RS08220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LREU_RS08225	COG0745	RESPONSE REGULATOR receiver
LREU_RS08255	COG1482	cell wall glycoprotein biosynthetic process
LREU_RS08260	COG1482	cell wall glycoprotein biosynthetic process
LREU_RS08265	COG0583	DNA-binding transcription factor activity
LREU_RS08275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LREU_RS08285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LREU_RS08300	COG1464	Belongs to the NlpA lipoprotein family
LREU_RS08305	COG1854	S-ribosylhomocysteine lyase activity
LREU_RS08320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LREU_RS08330	COG2801	Transposase and inactivated derivatives
LREU_RS08380	COG2814	Major facilitator Superfamily
LREU_RS08385	COG4475	Protein of unknown function (DUF436)
LREU_RS08400	COG2223	nitrite transmembrane transporter activity
LREU_RS08405	COG4974	Belongs to the 'phage' integrase family
LREU_RS08445	COG1002	Type II restriction enzyme, methylase subunits
LREU_RS08455	COG0519	Catalyzes the synthesis of GMP from XMP
LREU_RS08465	COG1072	(Pantothenic acid kinase))
LREU_RS08470	COG1368	sulfuric ester hydrolase activity
LREU_RS08480	COG0446	pyridine nucleotide-disulphide oxidoreductase
LREU_RS08495	COG3973	AAA domain
LREU_RS08500	COG0586	Pfam SNARE associated Golgi protein
LREU_RS08510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LREU_RS08515	COG2261	transglycosylase associated protein
LREU_RS08525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LREU_RS08530	COG1511	domain protein
LREU_RS08555	COG0735	belongs to the Fur family
LREU_RS08560	COG0194	GDP metabolic process
LREU_RS08565	COG2816	NAD+ diphosphatase activity
LREU_RS08570	COG0531	amino acid
LREU_RS08575	COG0477	Major facilitator Superfamily
LREU_RS08590	COG1177	transmembrane transport
LREU_RS08600	COG3842	ATPase activity
LREU_RS08605	COG2936	dipeptidyl-peptidase activity
LREU_RS08610	COG2267	carboxylic ester hydrolase activity
LREU_RS08620	COG0783	Belongs to the Dps family
LREU_RS08655	COG0492	ferredoxin-NADP+ reductase activity
LREU_RS08680	COG1122	ATPase activity
LREU_RS08700	COG3759	membrane
LREU_RS08710	COG1396	sequence-specific DNA binding
LREU_RS08720	COG0604	alcohol dehydrogenase
LREU_RS08720	COG3321	synthase
LREU_RS08725	COG3775	system Galactitol-specific IIC component
LREU_RS08730	COG2814	Major facilitator Superfamily
LREU_RS08735	COG1131	(ABC) transporter
LREU_RS08755	COG0095	Lipoate-protein ligase
LREU_RS08760	COG0589	response to stress
LREU_RS08770	COG1940	carbohydrate kinase activity
LREU_RS08775	COG1114	Component of the transport system for branched-chain amino acids
LREU_RS08785	COG0675	Transposase, IS605 OrfB family
LREU_RS08805	COG2188	Transcriptional regulator
LREU_RS08810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LREU_RS08830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LREU_RS08845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LREU_RS08860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LREU_RS08865	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
LREU_RS08870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LREU_RS08875	COG0113	porphobilinogen synthase activity
LREU_RS08880	COG0181	hydroxymethylbilane synthase activity
LREU_RS08885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LREU_RS08895	COG1492	cobalamin metabolic process
LREU_RS08900	COG1122	ATPase activity
LREU_RS08910	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
LREU_RS08915	COG0310	cobalt ion transport
LREU_RS08930	COG1587	Uroporphyrinogen-III synthase
LREU_RS08930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LREU_RS08965	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LREU_RS08980	COG1797	cobyrinic acid a,c-diamide synthase activity
LREU_RS08985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LREU_RS08995	COG2096	Adenosyltransferase
LREU_RS09000	COG0431	NADPH-dependent FMN reductase
LREU_RS09005	COG0716	FMN binding
LREU_RS09020	COG0588	phosphoglycerate mutase activity
LREU_RS09025	COG2365	Tyrosine phosphatase family
LREU_RS09035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LREU_RS09060	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LREU_RS09070	COG4869	propanediol catabolic process
LREU_RS09125	COG0849	cell division
LREU_RS09130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LREU_RS09145	COG0628	permease
LREU_RS09155	COG1846	Transcriptional regulator
LREU_RS09175	COG1253	flavin adenine dinucleotide binding
LREU_RS09190	COG2807	transmembrane transport
LREU_RS09200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LREU_RS09210	COG2211	Major facilitator Superfamily
LREU_RS09210	COG2190	(PTS) system
LREU_RS09230	COG0586	Pfam SNARE associated Golgi protein
LREU_RS09240	COG1609	Transcriptional regulator
LREU_RS09245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LREU_RS09250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LREU_RS09260	COG2365	Tyrosine phosphatase family
LREU_RS09265	COG1881	PFAM PEBP family protein
LREU_RS09285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LREU_RS09295	COG0656	L-ascorbic acid biosynthetic process
LREU_RS09300	COG0745	RESPONSE REGULATOR receiver
LREU_RS09305	COG2205	protein histidine kinase activity
LREU_RS09310	COG1136	(ABC) transporter
LREU_RS09325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LREU_RS09330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LREU_RS09335	COG2814	Major facilitator Superfamily
LREU_RS09340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LREU_RS09345	COG3620	sequence-specific DNA binding
LREU_RS09350	COG3590	peptidase
LREU_RS09370	COG2094	Belongs to the DNA glycosylase MPG family
LREU_RS09375	COG3189	MarR family transcriptional regulator
LREU_RS09380	COG2249	NAD(P)H dehydrogenase (quinone) activity
LREU_RS09405	COG2404	hydrolase activity, acting on ester bonds
LREU_RS09415	COG1114	Component of the transport system for branched-chain amino acids
LREU_RS09430	COG0488	(ABC) transporter
LREU_RS09470	COG4120	Belongs to the binding-protein-dependent transport system permease family
LREU_RS09485	COG0640	Transcriptional regulator
LREU_RS09490	COG0534	Mate efflux family protein
LREU_RS09495	COG3118	belongs to the thioredoxin family
LREU_RS09500	COG0861	Integral membrane protein TerC family
LREU_RS09505	COG0564	pseudouridine synthase activity
LREU_RS09525	COG1757	Na H antiporter
LREU_RS09530	COG0124	histidyl-tRNA synthetase
LREU_RS09555	COG1288	antiporter activity
LREU_RS09560	COG0588	phosphoglycerate mutase activity
LREU_RS09570	COG1368	sulfuric ester hydrolase activity
LREU_RS09585	COG1686	Belongs to the peptidase S11 family
LREU_RS09600	COG1376	ErfK ybiS ycfS ynhG family protein
LREU_RS09610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LREU_RS09620	COG0124	histidyl-tRNA synthetase
LREU_RS09625	COG2814	Major facilitator Superfamily
LREU_RS09640	COG1609	Transcriptional regulator
LREU_RS09645	COG1388	LysM domain
LREU_RS09645	COG1705	Flagellar rod assembly protein muramidase FlgJ
LREU_RS09650	COG0640	Transcriptional regulator
LREU_RS09660	COG1136	(ABC) transporter
LREU_RS09660	COG0577	efflux transmembrane transporter activity
LREU_RS09665	COG1136	(ABC) transporter
LREU_RS09685	COG1914	H( )-stimulated, divalent metal cation uptake system
LREU_RS09695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LREU_RS09710	COG0531	amino acid
LREU_RS09715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LREU_RS09730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LREU_RS09750	COG2153	protein acetylation
LREU_RS09760	COG1733	regulation of RNA biosynthetic process
LREU_RS09770	COG1733	regulation of RNA biosynthetic process
LREU_RS09785	COG3579	cysteine-type endopeptidase activity
LREU_RS09795	COG0308	aminopeptidase N
LREU_RS09800	COG4720	Psort location CytoplasmicMembrane, score
LREU_RS09805	COG2502	aspartate--ammonia ligase
LREU_RS09810	COG0017	Asparaginyl-tRNA synthetase
LREU_RS09820	COG3706	GGDEF domain
LREU_RS09830	COG1215	transferase activity, transferring glycosyl groups
LREU_RS09855	COG2910	NAD(P)H-binding
LREU_RS09870	COG0656	L-ascorbic acid biosynthetic process
LREU_RS09875	COG0583	DNA-binding transcription factor activity
LREU_RS09880	COG0252	asparaginase activity
LREU_RS09890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LREU_RS09915	COG0583	DNA-binding transcription factor activity
LREU_RS09925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LREU_RS09935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LREU_RS09990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LREU_RS09995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LREU_RS10000	COG1285	pathogenesis
LREU_RS10015	COG1687	branched-chain amino acid
LREU_RS10020	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LREU_RS10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LREU_RS10055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LREU_RS10060	COG0367	asparagine synthase
LREU_RS10065	COG0445	tRNA wobble uridine modification
LREU_RS10070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LREU_RS10080	COG0706	membrane insertase activity
LREU_RS10085	COG0594	ribonuclease P activity
LREU_RS10090	COG0230	Belongs to the bacterial ribosomal protein bL34 family