locus-tag class description LROSL3_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LROSL3_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LROSL3_RS00015 ENOG410848D S4 domain protein YaaA LROSL3_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LROSL3_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LROSL3_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LROSL3_RS00040 ENOG4105K8R UPF0145 protein LROSL3_RS00045 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LROSL3_RS00050 ENOG4108UUM single-stranded DNA-binding protein LROSL3_RS00065 ENOG4105K9Q Binds to the 23S rRNA (By similarity) LROSL3_RS00070 ENOG4105CDU Replicative dna helicase LROSL3_RS00090 ENOG4105EWI Short-chain dehydrogenase reductase Sdr LROSL3_RS00095 ENOG4105DC1 bifunctional purine biosynthesis protein purh LROSL3_RS00105 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LROSL3_RS00135 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LROSL3_RS00150 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) LROSL3_RS00185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LROSL3_RS00195 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS00200 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr LROSL3_RS00290 ENOG4105CWM branched-chain amino acid transport system II carrier protein LROSL3_RS00295 ENOG4108IG5 Transcriptional regulator LROSL3_RS00310 ENOG4108V4B ThiJ pfpI LROSL3_RS00320 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS00325 ENOG4105D01 (LipO)protein LROSL3_RS00330 ENOG4105CMG Carbohydrate kinase LROSL3_RS00335 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LROSL3_RS00340 ENOG4107QNK )-transporter LROSL3_RS00350 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS00385 ENOG4108YZG isomerase LROSL3_RS00390 ENOG4107QM2 Aldo Keto reductase LROSL3_RS00395 ENOG4105VUF Transcriptional regulator LROSL3_RS00415 ENOG4105EYH Exonuclease LROSL3_RS00425 ENOG4105F1N DNA alkylation repair LROSL3_RS00430 ENOG4105D29 Helix-turn-helix type 11 domain protein LROSL3_RS00440 ENOG4107QVI Methyltransferase, type 11 LROSL3_RS00445 ENOG4105U3E Transcriptional regulator LROSL3_RS00470 ENOG4105ECB domain protein LROSL3_RS00475 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS00490 ENOG4108X0B nad(p)h dehydrogenase (quinone) LROSL3_RS00495 ENOG4105CXT aspartate transcarbamylase LROSL3_RS00500 ENOG4105CD3 dihydroorotase LROSL3_RS00505 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LROSL3_RS00510 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LROSL3_RS00520 ENOG4105KRQ Addiction module toxin, Txe YoeB family LROSL3_RS00525 ENOG410631K Membrane LROSL3_RS00565 ENOG4105K56 Transcriptional regulator LROSL3_RS00575 ENOG4108IUW ABC transporter LROSL3_RS00595 ENOG4108R6K riboflavin synthase, subunit alpha LROSL3_RS00600 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LROSL3_RS00605 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LROSL3_RS00610 ENOG4108V06 Glutathione peroxidase LROSL3_RS00615 ENOG4107BMA Transglycosylase associated protein LROSL3_RS00645 ENOG4105CHR reductase LROSL3_RS00655 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS00675 ENOG4105C5H ABC transporter LROSL3_RS00685 ENOG4107EFR Flavocytochrome c LROSL3_RS00705 ENOG4105E5Q amino acid AbC transporter LROSL3_RS00710 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein LROSL3_RS00715 ENOG4105KVH Transcriptional regulator LROSL3_RS00745 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS00775 ENOG4105C6X Major Facilitator LROSL3_RS00780 ENOG4105BZU Histidine kinase LROSL3_RS00805 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS00810 ENOG4107V2S Transcriptional regulator LROSL3_RS00820 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LROSL3_RS00830 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LROSL3_RS00835 ENOG4105CV8 reductase LROSL3_RS00850 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LROSL3_RS00855 ENOG4105C9Q fumarate hydratase class II LROSL3_RS00860 ENOG4107QPK )-transporter LROSL3_RS00875 ENOG4105CPC Aldo Keto reductase LROSL3_RS00885 ENOG4105DKT Transcriptional regulator LROSL3_RS00895 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) LROSL3_RS00910 ENOG4105C5Q Transcriptional regulator LROSL3_RS00915 ENOG4107EFR Flavocytochrome c LROSL3_RS00930 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LROSL3_RS00935 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase LROSL3_RS00940 ENOG41062SP LROSL3_RS00945 ENOG4105RHA ABC transporter, permease LROSL3_RS00950 ENOG4108IUX (ABC) transporter LROSL3_RS00965 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS00975 ENOG4106432 Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) LROSL3_RS00980 ENOG4105C85 amino acid LROSL3_RS00990 ENOG4105PY6 Phenolic acid decarboxylase LROSL3_RS00995 ENOG4105U3E Transcriptional regulator LROSL3_RS01005 ENOG4105CQB FAD linked oxidase domain protein LROSL3_RS01035 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LROSL3_RS01040 ENOG4105KP9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LROSL3_RS01045 ENOG4105K64 Glycosyl transferase, family 2 LROSL3_RS01055 ENOG4105E2X shikimate dehydrogenase LROSL3_RS01060 ENOG4105EMV Major Facilitator LROSL3_RS01065 ENOG4105FF2 Type I DHQase LROSL3_RS01075 ENOG4107EFR Flavocytochrome c LROSL3_RS01130 ENOG4107Y80 Major Facilitator superfamily LROSL3_RS01145 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LROSL3_RS01150 ENOG4107YU2 histidine triad (hIT) protein LROSL3_RS01165 ENOG4105C6K Malic enzyme LROSL3_RS01170 ENOG4107ZGM malolactic fermentation system LROSL3_RS01225 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LROSL3_RS01230 ENOG4105DD7 kinase (PfkB family LROSL3_RS01235 ENOG4105DD7 kinase (PfkB family LROSL3_RS01240 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase LROSL3_RS01255 ENOG4105D9N nucleoside LROSL3_RS01280 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) LROSL3_RS01290 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LROSL3_RS01300 ENOG4107QNK )-transporter LROSL3_RS01315 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) LROSL3_RS01320 ENOG4108UW5 maltose o-acetyltransferase LROSL3_RS01325 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) LROSL3_RS01330 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) LROSL3_RS01340 ENOG4105CPC Aldo Keto reductase LROSL3_RS01370 ENOG4105KAF membrAne LROSL3_RS01400 ENOG4105D8X mechanosensitive ion channel LROSL3_RS01415 ENOG4107QJZ Glycosyl transferase, family 2 LROSL3_RS01420 ENOG4105E2D ec 3.2.1.52 LROSL3_RS01430 ENOG4105D5T phosphonate abc transporter LROSL3_RS01445 ENOG4105DU0 nucleoside hydrolase LROSL3_RS01485 ENOG410605W Major Facilitator LROSL3_RS01500 ENOG4105EEQ Na H antiporter LROSL3_RS01505 ENOG4105D7W serine acetyltransferase LROSL3_RS01510 ENOG4105C6T cysteine synthase LROSL3_RS01530 ENOG4105CEN a g-specific adenine glycosylase LROSL3_RS01535 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LROSL3_RS01560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LROSL3_RS01565 ENOG4108HRK Histidine kinase LROSL3_RS01575 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) LROSL3_RS01580 ENOG41067MG lrgb family LROSL3_RS01585 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) LROSL3_RS01590 ENOG41067MG lrgb family LROSL3_RS01600 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LROSL3_RS01605 ENOG4105DZW Dipeptidase LROSL3_RS01620 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LROSL3_RS01630 ENOG4105CD8 aminopeptidase N LROSL3_RS01650 ENOG4107U9W Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) LROSL3_RS01670 ENOG4105F9F transposase LROSL3_RS01675 ENOG4106432 Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) LROSL3_RS01685 ENOG4105M2Z protein tyrosine serine phosphatase LROSL3_RS01705 ENOG4108RYK Nad-dependent epimerase dehydratase LROSL3_RS01715 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS01725 ENOG4107YZX Universal stress protein LROSL3_RS01730 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LROSL3_RS01735 ENOG4105PGM cation diffusion facilitator family transporter LROSL3_RS01740 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) LROSL3_RS01765 ENOG4108HCJ Hydrolase LROSL3_RS01770 ENOG4105DJ2 Major Facilitator Superfamily LROSL3_RS01775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LROSL3_RS01785 ENOG4105CPQ Dehydrogenase LROSL3_RS01790 ENOG4105KA3 membrAne LROSL3_RS01800 ENOG4107T5V SNARE associated Golgi LROSL3_RS01820 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LROSL3_RS01825 ENOG41083J0 (ABC) transporter LROSL3_RS01830 ENOG4105C4B ABC transporter, permease LROSL3_RS01865 ENOG4105CG5 Glycosyl transferase (Group 1 LROSL3_RS01875 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LROSL3_RS01890 ENOG4105DF9 Lipoate-protein, ligase LROSL3_RS01915 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) LROSL3_RS01925 ENOG4107QJE Chromosome Partitioning Protein LROSL3_RS01930 ENOG4105FA0 parb-like partition protein LROSL3_RS01935 ENOG4105VDK protein, conserved in bacteria LROSL3_RS01940 ENOG4105C3G gtp-binding protein LROSL3_RS01960 ENOG4105ECB domain protein LROSL3_RS01960 ENOG4105ECB domain protein LROSL3_RS01990 ENOG4108NUI synthase LROSL3_RS02000 ENOG4106F5Q Membrane LROSL3_RS02005 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LROSL3_RS02025 ENOG4105D29 Helix-turn-helix type 11 domain protein LROSL3_RS02030 ENOG4105C3S Mate efflux family protein LROSL3_RS02035 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LROSL3_RS02060 ENOG4105DT3 PTS system, galactitol-specific IIc component LROSL3_RS02065 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) LROSL3_RS02080 ENOG4105CJ1 ABC, transporter LROSL3_RS02110 ENOG4105ECR NmrA family LROSL3_RS02115 ENOG4105E1F short-chain dehydrogenase reductase LROSL3_RS02130 ENOG4105CSM endonuclease III LROSL3_RS02135 ENOG4108J59 Extracellular solute-binding protein, family 5 LROSL3_RS02140 ENOG4107QHE Choloylglycine hydrolase LROSL3_RS02145 ENOG4105CPT Alpha beta hydrolase LROSL3_RS02150 ENOG4105DS0 Transcriptional regulator, Crp Fnr family LROSL3_RS02155 ENOG41090U3 tautomerase LROSL3_RS02165 ENOG4108W5M transcriptional regulator LROSL3_RS02185 ENOG4108UW5 maltose o-acetyltransferase LROSL3_RS02195 ENOG4105EMU Dehydrogenase LROSL3_RS02210 ENOG4107XVH Transcriptional regulator LROSL3_RS02215 ENOG4107QW4 alcohol dehydrogenase LROSL3_RS02220 ENOG4108UXE Protein tyrosine phosphatase LROSL3_RS02245 ENOG4105ECR NmrA family LROSL3_RS02250 ENOG4108Z40 Transcriptional regulator LROSL3_RS02270 ENOG4105C59 p-type ATPase LROSL3_RS02280 ENOG4107DB1 DUF218 domain LROSL3_RS02285 ENOG4107QHE Choloylglycine hydrolase LROSL3_RS02290 ENOG4108UW5 maltose o-acetyltransferase LROSL3_RS02295 ENOG41082BM Transcriptional regulator, arsr family LROSL3_RS02300 ENOG4108JA1 polyketide synthase LROSL3_RS02310 ENOG4105CHR reductase LROSL3_RS02320 ENOG4105E2A Dehydrogenase LROSL3_RS02345 ENOG4105VBF alkaline shock protein LROSL3_RS02360 ENOG4108Y4K DNA-binding transcriptional activator LROSL3_RS02390 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LROSL3_RS02405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LROSL3_RS02425 ENOG4105MKU Transcriptional regulator LROSL3_RS02430 ENOG41067TZ transcriptional regulator, MarR family LROSL3_RS02435 ENOG4105BZ1 (ABC) transporter LROSL3_RS02440 ENOG4105C3S Mate efflux family protein LROSL3_RS02460 ENOG4105CHR reductase LROSL3_RS02500 ENOG4107YDN peptide deformylase LROSL3_RS02515 ENOG4105C7N Xanthine uracil vitamin C permease LROSL3_RS02550 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) LROSL3_RS02565 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LROSL3_RS02570 ENOG4108V7D UPF0397 protein LROSL3_RS02575 ENOG4108JJB ABC transporter LROSL3_RS02580 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) LROSL3_RS02590 ENOG4105J7I hydrolase LROSL3_RS02615 ENOG4105K63 Thioredoxin LROSL3_RS02625 ENOG4105XTG Pfam:DUF156 LROSL3_RS02635 ENOG4105D9U N-acetyltransferase LROSL3_RS02640 ENOG41068WN LROSL3_RS02685 ENOG4105CHJ isochorismatase hydrolase LROSL3_RS02700 ENOG4105BZ1 (ABC) transporter LROSL3_RS02720 ENOG4108UW5 maltose o-acetyltransferase LROSL3_RS02725 ENOG4105C94 Transporter LROSL3_RS02795 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) LROSL3_RS02805 ENOG4108IJ8 ABC transporter LROSL3_RS02820 ENOG4105DC8 reductase LROSL3_RS02835 ENOG4105EEM helicase LROSL3_RS02860 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LROSL3_RS02875 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) LROSL3_RS02880 ENOG4105F8V Hydrolase, tatD family LROSL3_RS02885 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) LROSL3_RS02890 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) LROSL3_RS02895 ENOG4105W42 Veg protein LROSL3_RS02900 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) LROSL3_RS02920 ENOG4105FDK ABC transporter LROSL3_RS02930 ENOG4105DFT pur operon repressor LROSL3_RS02935 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LROSL3_RS02940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LROSL3_RS02955 ENOG410667J hydrolase LROSL3_RS02960 ENOG4105DCI Phosphohydrolase LROSL3_RS02965 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) LROSL3_RS02980 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LROSL3_RS02985 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LROSL3_RS03000 ENOG4105C6X Major Facilitator LROSL3_RS03005 ENOG4108Z6X (sortase) family LROSL3_RS03010 ENOG4105KJF protein tyrosine phosphatase LROSL3_RS03015 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) LROSL3_RS03020 ENOG4105C1J atp-dependent rna helicase LROSL3_RS03025 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LROSL3_RS03030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LROSL3_RS03040 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) LROSL3_RS03050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LROSL3_RS03055 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) LROSL3_RS03060 ENOG4108JA2 transcriptioN-repair coupling factor LROSL3_RS03070 ENOG41082I2 s4 domain protein LROSL3_RS03080 ENOG41060GV RNA binding s1 domain protein LROSL3_RS03085 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LROSL3_RS03090 ENOG4108UGV hypoxanthine phosphoribosyltransferase LROSL3_RS03100 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) LROSL3_RS03105 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LROSL3_RS03110 ENOG4105CRK lysyL-tRNA synthetase LROSL3_RS03140 ENOG4105DUX Transporter LROSL3_RS03160 ENOG4105D1H recombination factor protein RarA LROSL3_RS03165 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein LROSL3_RS03170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LROSL3_RS03175 ENOG4105II7 pyrroline-5-carboxylate reductase LROSL3_RS03180 ENOG4105CE4 GlcNAc 6-P deacetylase LROSL3_RS03190 ENOG4105DAP Nicotinate phosphoribosyltransferase LROSL3_RS03195 ENOG4107RA1 nh(3)-dependent nad( ) synthetase LROSL3_RS03210 ENOG410906U SprT-like LROSL3_RS03215 ENOG4106F5Q Membrane LROSL3_RS03250 ENOG4107GJV short-chain dehydrogenase reductase LROSL3_RS03255 ENOG4108KGH TRANSCRIPTIONal LROSL3_RS03260 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LROSL3_RS03265 ENOG4105IJJ transcriptional regulator, crp fnr family LROSL3_RS03285 ENOG4105ETZ PTS System LROSL3_RS03290 ENOG4105F3R pts system mannose fructose sorbose family iid LROSL3_RS03310 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LROSL3_RS03315 ENOG4105US7 Histidine kinase LROSL3_RS03320 ENOG4108STX response regulator LROSL3_RS03355 ENOG41062ES Transcriptional regulator LROSL3_RS03360 ENOG4108IQI permease LROSL3_RS03365 ENOG4105ZMH deoxynucleoside kinase LROSL3_RS03400 ENOG4105SFS phosphoesterase RecJ domain protein LROSL3_RS03415 ENOG4108UZ3 Transporter LROSL3_RS03425 ENOG4105C5I Dehydrogenase LROSL3_RS03430 ENOG4105ETU transcriptional activator (TenA LROSL3_RS03435 ENOG4105KEX transcriptional regulator, ctsr LROSL3_RS03445 ENOG4105F9F transposase LROSL3_RS03455 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LROSL3_RS03460 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LROSL3_RS03465 ENOG4105CCI Myosin-Cross-Reactive Antigen LROSL3_RS03470 ENOG41082YX Transcriptional regulator, arsr family LROSL3_RS03480 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) LROSL3_RS03485 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LROSL3_RS03490 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LROSL3_RS03495 ENOG4105DZW Dipeptidase LROSL3_RS03510 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LROSL3_RS03515 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LROSL3_RS03520 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LROSL3_RS03525 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LROSL3_RS03530 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LROSL3_RS03540 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LROSL3_RS03545 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) LROSL3_RS03550 ENOG41082SA 50s ribosomal protein l29 LROSL3_RS03555 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal LROSL3_RS03560 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) LROSL3_RS03565 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) LROSL3_RS03575 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LROSL3_RS03580 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) LROSL3_RS03585 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) LROSL3_RS03590 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) LROSL3_RS03595 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) LROSL3_RS03600 ENOG41084KY 50S ribosomal protein L30 LROSL3_RS03605 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) LROSL3_RS03610 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LROSL3_RS03620 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) LROSL3_RS03625 ENOG41067V7 50S ribosomal protein L36 LROSL3_RS03630 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits LROSL3_RS03635 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) LROSL3_RS03640 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LROSL3_RS03645 ENOG4108ZT0 50S ribosomal protein l17 LROSL3_RS03655 ENOG4108JJB ABC transporter LROSL3_RS03675 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) LROSL3_RS03680 ENOG4108UJD 30S ribosomal protein S9 LROSL3_RS03715 ENOG4105CUB amino acid LROSL3_RS03720 ENOG4105F9U Dehydrogenase LROSL3_RS03725 ENOG4105C4M (Ubiquinol oxidase) subunit I LROSL3_RS03730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LROSL3_RS03735 ENOG4108JJ9 ABC, transporter LROSL3_RS03740 ENOG4108JJ8 (ABC) transporter LROSL3_RS03765 ENOG4105EAH synthase LROSL3_RS03775 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LROSL3_RS03785 ENOG4105C4R Atp-dependent dna helicase LROSL3_RS03800 ENOG4105DFH Transport of potassium into the cell (By similarity) LROSL3_RS03805 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LROSL3_RS03810 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) LROSL3_RS03815 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LROSL3_RS03820 ENOG4105CBD Diacylglycerol kinase LROSL3_RS03825 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LROSL3_RS03830 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) LROSL3_RS03845 ENOG4105VZ8 Transcriptional regulator LROSL3_RS03870 ENOG4105CMG Carbohydrate kinase LROSL3_RS03875 ENOG4106KNT transcriptional regulator LROSL3_RS03915 ENOG4105EE0 oxidoreductase LROSL3_RS03920 ENOG4105FDU atp-dependent rna helicase LROSL3_RS03925 ENOG41090U3 tautomerase LROSL3_RS03940 ENOG4105DWF phosphomethylpyrimidine kinase LROSL3_RS03945 ENOG4105K56 Transcriptional regulator LROSL3_RS03960 ENOG4105WH5 Teichoic acid glycosylation protein LROSL3_RS03970 ENOG4105WH5 Teichoic acid glycosylation protein LROSL3_RS03985 ENOG4105NQC Flavodoxin LROSL3_RS03995 ENOG4106MCE EamA-like transporter family LROSL3_RS04000 ENOG4108KN0 Choline kinase LROSL3_RS04010 ENOG4105D3Q Sugar transferase LROSL3_RS04020 ENOG4107XU6 Glycosyl transferase (Group 1 LROSL3_RS04025 ENOG4105D5D udp-galactopyranose mutase LROSL3_RS04030 ENOG4105EVI UPF0374 protein LROSL3_RS04035 ENOG4105C02 permease LROSL3_RS04040 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LROSL3_RS04050 ENOG4108MKI Glycosyl transferase, family 2 LROSL3_RS04055 ENOG4105KPE licD family LROSL3_RS04075 ENOG410838F Glycosyl transferase family 2 LROSL3_RS04110 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) LROSL3_RS04115 ENOG4105D0M Protease HtpX homolog LROSL3_RS04120 ENOG4108V0P LemA family LROSL3_RS04145 ENOG4105DQ6 Transposase LROSL3_RS04155 ENOG4108TCS Glutamyl endopeptidase LROSL3_RS04160 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LROSL3_RS04180 ENOG4105KRI phosphocarrier protein (HPr LROSL3_RS04185 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) LROSL3_RS04190 ENOG4105BZF Glycosyl transferase (Group 1 LROSL3_RS04195 ENOG4105W2C Glycosyl transferase LROSL3_RS04210 ENOG4105E0M Sulfatase LROSL3_RS04340 ENOG4105CDY transcriptional regulatory protein LROSL3_RS04350 ENOG4106855 Competence protein LROSL3_RS04385 ENOG4105C85 amino acid LROSL3_RS04395 ENOG4105MMD transcriptional regulator LROSL3_RS04400 ENOG4105D4U had-superfamily hydrolase, subfamily iia LROSL3_RS04410 ENOG4105DQR SNARE associated Golgi LROSL3_RS04415 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LROSL3_RS04420 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LROSL3_RS04550 ENOG4108RQ5 Beta-lactamase domain-containing protein LROSL3_RS04555 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LROSL3_RS04560 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis LROSL3_RS04580 ENOG4105DPN Oligoendopeptidase f LROSL3_RS04595 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LROSL3_RS04600 ENOG4105EMS pseudouridine synthase LROSL3_RS04605 ENOG4106N3A copper homeostasis protein cutc LROSL3_RS04610 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LROSL3_RS04625 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) LROSL3_RS04630 ENOG4105CNU cell division protein FtsK LROSL3_RS04650 ENOG4108V6E Cell division protein mraZ LROSL3_RS04665 ENOG4105CJN penicillin-binding protein LROSL3_RS04670 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LROSL3_RS04675 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) LROSL3_RS04680 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LROSL3_RS04685 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) LROSL3_RS04700 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) LROSL3_RS04705 ENOG41067XK integral membrane protein LROSL3_RS04715 ENOG4105MMF Cell division protein DIVIVA LROSL3_RS04720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LROSL3_RS04735 ENOG4105VEQ Cold shock protein LROSL3_RS04740 ENOG4108YZ4 nudix hydrolase LROSL3_RS04750 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) LROSL3_RS04755 ENOG4105C3J Cysteine desulfurase LROSL3_RS04765 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LROSL3_RS04770 ENOG4108TGR phosphatase LROSL3_RS04780 ENOG4105C7H Helicase, RecD TraA family LROSL3_RS04790 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LROSL3_RS04795 ENOG4105CPC Aldo Keto reductase LROSL3_RS04800 ENOG4105D01 (LipO)protein LROSL3_RS04805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LROSL3_RS04810 ENOG4108UMI ABC transporter, permease LROSL3_RS04840 ENOG4105DZC cytosine deaminase LROSL3_RS04850 ENOG4107FQX Alpha-acetolactate decarboxylase LROSL3_RS04855 ENOG4108HCJ Hydrolase LROSL3_RS04865 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LROSL3_RS04875 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LROSL3_RS04890 ENOG4107RHR regulatoR LROSL3_RS04920 ENOG4108F01 MaoC domain protein LROSL3_RS04925 ENOG4105E39 Enoyl-CoA hydratase LROSL3_RS04930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LROSL3_RS04935 ENOG4105RKW reductase (By LROSL3_RS04940 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) LROSL3_RS04945 ENOG4105CMU LysR family (Transcriptional regulator LROSL3_RS04950 ENOG4105CS9 pantothenic acid kinase LROSL3_RS04960 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LROSL3_RS04965 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS04980 ENOG4107EFR Flavocytochrome c LROSL3_RS04995 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LROSL3_RS05000 ENOG4105EDR glucose galactose transporter LROSL3_RS05020 ENOG4105CSX c4-dicarboxylate anaerobic carrier LROSL3_RS05030 ENOG4105CEU Arginine dihydrolase LROSL3_RS05040 ENOG4105D5Q Arginine ornithine antiporter LROSL3_RS05045 ENOG4105CHM Aminotransferase LROSL3_RS05060 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LROSL3_RS05065 ENOG4108IQI permease LROSL3_RS05070 ENOG4105C75 arginyL-tRNA synthetase LROSL3_RS05085 ENOG4108KB2 LysR family Transcriptional regulator LROSL3_RS05100 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LROSL3_RS05110 ENOG4105DBV ornithine carbamoyltransferase LROSL3_RS05115 ENOG410839U amino acid LROSL3_RS05120 ENOG4105DWY Agmatine deiminase LROSL3_RS05205 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS05215 ENOG4105D5Q Arginine ornithine antiporter LROSL3_RS05220 ENOG4105DWF phosphomethylpyrimidine kinase LROSL3_RS05235 ENOG4108UIC UPF0340 protein LROSL3_RS05240 ENOG4105PUK Membrane LROSL3_RS05265 ENOG4108UIC UPF0340 protein LROSL3_RS05270 ENOG4105PUK Membrane LROSL3_RS05280 ENOG4105C5I Dehydrogenase LROSL3_RS05285 ENOG4108MRH transcriptional regulatory protein LROSL3_RS05300 ENOG4108MXF Alpha Beta Hydrolase LROSL3_RS05325 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase LROSL3_RS05345 ENOG4105H9W Short-chain dehydrogenase reductase Sdr LROSL3_RS05350 ENOG4107SN7 NLP P60 protein LROSL3_RS05370 ENOG4105CN5 Metallo-Beta-Lactamase LROSL3_RS05375 ENOG4106EHS UPF0356 protein LROSL3_RS05395 ENOG4107RUY (E1 component), alpha subunit LROSL3_RS05400 ENOG4105CPP Dehydrogenase, E1 component LROSL3_RS05420 ENOG4105WBI UPF0223 protein LROSL3_RS05425 ENOG4105ECY inositol monophosphatase LROSL3_RS05430 ENOG4105CI3 gtp-binding protein typa LROSL3_RS05435 ENOG4105CNI cell division protein FtsW LROSL3_RS05440 ENOG4105WUC UPF0298 protein LROSL3_RS05445 ENOG4106H78 methyltransferase LROSL3_RS05450 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LROSL3_RS05455 ENOG41063PX domain protein LROSL3_RS05460 ENOG4105KQC Competence protein LROSL3_RS05465 ENOG4108UK2 deaminase LROSL3_RS05470 ENOG4108EC8 DNA internalization-related competence protein ComEC LROSL3_RS05475 ENOG4105TQK DNA polymerase iii, delta' subunit LROSL3_RS05480 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LROSL3_RS05485 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) LROSL3_RS05500 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LROSL3_RS05505 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LROSL3_RS05510 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LROSL3_RS05515 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LROSL3_RS05530 ENOG4105E5Q amino acid AbC transporter LROSL3_RS05535 ENOG4105CDA abc transporter atp-binding protein LROSL3_RS05540 ENOG4107PP3 Acetylornithine deacetylase LROSL3_RS05545 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LROSL3_RS05555 ENOG4105EXC Acyl-transferase LROSL3_RS05565 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LROSL3_RS05570 ENOG4108IXY short-chain dehydrogenase reductase LROSL3_RS05575 ENOG41067VP Protein of unknown function (DUF1049) LROSL3_RS05580 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LROSL3_RS05585 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LROSL3_RS05595 ENOG41086FC 50S ribosomal protein l32 LROSL3_RS05605 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase LROSL3_RS05625 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LROSL3_RS05630 ENOG4105VPS UPF0291 protein LROSL3_RS05635 ENOG4105VXM UPF0154 protein LROSL3_RS05640 ENOG4105BZ1 (ABC) transporter LROSL3_RS05645 ENOG4105BZ1 (ABC) transporter LROSL3_RS05650 ENOG4105F6E Acyl-transferase LROSL3_RS05655 ENOG41060K3 Methyltransferase LROSL3_RS05660 ENOG4105VC4 domain protein LROSL3_RS05665 ENOG4105C5I Dehydrogenase LROSL3_RS05670 ENOG4105CE9 30S ribosomal protein S2 LROSL3_RS05675 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) LROSL3_RS05680 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LROSL3_RS05685 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LROSL3_RS05690 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LROSL3_RS05695 ENOG4105KNE Phosphatidate cytidylyltransferase LROSL3_RS05700 ENOG4105DZP Membrane-associated zinc metalloprotease LROSL3_RS05705 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LROSL3_RS05710 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) LROSL3_RS05715 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase LROSL3_RS05720 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) LROSL3_RS05725 ENOG4105CHV Transcription elongation factor NusA LROSL3_RS05730 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination LROSL3_RS05740 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LROSL3_RS05740 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LROSL3_RS05745 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LROSL3_RS05750 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LROSL3_RS05755 ENOG4105DTN riboflavin biosynthesis protein ribF LROSL3_RS05760 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) LROSL3_RS05765 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ LROSL3_RS05775 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LROSL3_RS05780 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) LROSL3_RS05790 ENOG4105CIS alcohol dehydrogenase LROSL3_RS05795 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LROSL3_RS05800 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LROSL3_RS05810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LROSL3_RS05825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LROSL3_RS05830 ENOG4105CUT histidyl-tRNA synthetase LROSL3_RS05835 ENOG4105C9M aspartyl-trna synthetase LROSL3_RS05845 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) LROSL3_RS05855 ENOG4107AYK membrAne LROSL3_RS05860 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LROSL3_RS05870 ENOG4105KTH gatB Yqey LROSL3_RS05875 ENOG4105C9A Phoh family LROSL3_RS05885 ENOG4107YR5 Diacylglycerol kinase LROSL3_RS05890 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) LROSL3_RS05895 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) LROSL3_RS05900 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit LROSL3_RS05905 ENOG4105C38 Glycyl-tRNA synthetase beta subunit LROSL3_RS05915 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LROSL3_RS05920 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LROSL3_RS05930 ENOG4105EGD dinuclear metal center protein, YbgI family LROSL3_RS05935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LROSL3_RS05945 ENOG4105C0B DNA polymerase III (alpha subunit) LROSL3_RS05950 ENOG4105CA9 Pyruvate kinase LROSL3_RS05955 ENOG4105QNR S1 RNA binding domain protein LROSL3_RS05970 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) LROSL3_RS05975 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) LROSL3_RS05980 ENOG4105FE9 pseudouridine synthase LROSL3_RS05985 ENOG4108SAX Membrane LROSL3_RS05995 ENOG4105C9U ATP-dependent DNA helicase RecQ LROSL3_RS06005 ENOG4105CAT Cytidine monophosphate kinase LROSL3_RS06010 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LROSL3_RS06015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) LROSL3_RS06025 ENOG41068YB TPR repeat-containing protein LROSL3_RS06035 ENOG4108JYZ YitT family LROSL3_RS06045 ENOG4105C5H ABC transporter LROSL3_RS06050 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LROSL3_RS06055 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LROSL3_RS06060 ENOG4108UT2 hemolysin iii LROSL3_RS06065 ENOG4108RCR degv family LROSL3_RS06070 ENOG41090WU lipolytic protein G-D-S-L family LROSL3_RS06075 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) LROSL3_RS06080 ENOG4105VSD UPF0346 protein LROSL3_RS06085 ENOG4108IMY Transcriptional regulator LROSL3_RS06135 ENOG4105EMY transcriptional regulator LROSL3_RS06165 ENOG4105EDR glucose galactose transporter LROSL3_RS06175 ENOG4105CMG Carbohydrate kinase LROSL3_RS06190 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LROSL3_RS06195 ENOG4105C79 DNA protecting protein DprA LROSL3_RS06200 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LROSL3_RS06205 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) LROSL3_RS06210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LROSL3_RS06220 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LROSL3_RS06225 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LROSL3_RS06235 ENOG4105DND Transcriptional regulator LROSL3_RS06240 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase LROSL3_RS06255 ENOG4105E0X reductase LROSL3_RS06260 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LROSL3_RS06265 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LROSL3_RS06270 ENOG4105DWF phosphomethylpyrimidine kinase LROSL3_RS06275 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LROSL3_RS06290 ENOG4108J59 Extracellular solute-binding protein, family 5 LROSL3_RS06305 ENOG4108M15 ABC transporter LROSL3_RS06315 ENOG4105BZU Histidine kinase LROSL3_RS06370 ENOG4105BZ1 (ABC) transporter LROSL3_RS06375 ENOG41080TK Universal stress protein LROSL3_RS06385 ENOG4105CV8 reductase LROSL3_RS06395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LROSL3_RS06400 ENOG4105CV8 reductase LROSL3_RS06410 ENOG4105EPR degv family LROSL3_RS06425 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LROSL3_RS06430 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LROSL3_RS06435 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) LROSL3_RS06440 ENOG4105C34 Pseudouridine synthase LROSL3_RS06445 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) LROSL3_RS06450 ENOG4105CKU formyltetrahydrofolate synthetase LROSL3_RS06470 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LROSL3_RS06480 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) LROSL3_RS06485 ENOG4108UKS UPF0398 protein LROSL3_RS06490 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) LROSL3_RS06505 ENOG4105C5S asparaginyl-tRNA synthetase LROSL3_RS06515 ENOG4105DVT helicase LROSL3_RS06535 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) LROSL3_RS06540 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LROSL3_RS06545 ENOG4108KP7 hydrolase LROSL3_RS06555 ENOG4108UZ3 Transporter LROSL3_RS06565 ENOG4107AYK membrAne LROSL3_RS06570 ENOG4105DZW Dipeptidase LROSL3_RS06575 ENOG4107SC7 Inner membrane transporter yjeM LROSL3_RS06585 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LROSL3_RS06590 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) LROSL3_RS06595 ENOG4105VB6 UPF0109 protein LROSL3_RS06600 ENOG4105K5M 30s ribosomal protein S16 LROSL3_RS06620 ENOG4105VEQ Cold shock protein LROSL3_RS06630 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LROSL3_RS06640 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LROSL3_RS06645 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY LROSL3_RS06650 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) LROSL3_RS06665 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LROSL3_RS06670 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) LROSL3_RS06675 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) LROSL3_RS06680 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LROSL3_RS06685 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LROSL3_RS06690 ENOG4105CB5 ATP-dependent DNA helicase recG LROSL3_RS06695 ENOG4105DP4 dak2 domain fusion protein ylov LROSL3_RS06700 ENOG4108ZAA Alkaline-shock protein LROSL3_RS06705 ENOG4105VB9 50S ribosomal protein l28 LROSL3_RS06710 ENOG4105FJ0 thiamine LROSL3_RS06715 ENOG4105DJV ribulose-phosphate 3-epimerase LROSL3_RS06725 ENOG4105D9P serine threonine protein kinase LROSL3_RS06730 ENOG4108ZF3 Phosphatase LROSL3_RS06735 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LROSL3_RS06740 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LROSL3_RS06745 ENOG4105C25 Primosomal protein n' LROSL3_RS06750 ENOG4105C71 hydrolase family 65, central catalytic LROSL3_RS06755 ENOG4107URF beta-phospho-glucomutase LROSL3_RS06760 ENOG4105KIS phospholipid-binding protein LROSL3_RS06770 ENOG4108X4Q Hydrolase LROSL3_RS06780 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LROSL3_RS06790 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LROSL3_RS06795 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LROSL3_RS06800 ENOG4105DX0 Hemolysin A LROSL3_RS06810 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LROSL3_RS06815 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LROSL3_RS06820 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LROSL3_RS06830 ENOG4108ZSR alkaline shock protein LROSL3_RS06835 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LROSL3_RS06840 ENOG4105DC7 peptidase M24 LROSL3_RS06845 ENOG4105K46 50S ribosomal protein l27 LROSL3_RS06895 ENOG4105KV4 Transcriptional regulator LROSL3_RS06905 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LROSL3_RS06915 ENOG4105WZW rhodanese family LROSL3_RS06925 ENOG4107ZXI Rhomboid family LROSL3_RS06930 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LROSL3_RS06935 ENOG4105WDJ 50S ribosomal protein L33 LROSL3_RS06940 ENOG4107RF6 penicillin-binding protein LROSL3_RS06950 ENOG4105W8X HesB YadR YfhF-family protein LROSL3_RS06960 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LROSL3_RS06965 ENOG4105DBI uridine monophosphokinase LROSL3_RS06970 ENOG4105HHA aminodeoxychorismate lyase LROSL3_RS06975 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LROSL3_RS06980 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LROSL3_RS06995 ENOG4108RWN rrna methyltransferase LROSL3_RS07000 ENOG410855V Acylphosphatase LROSL3_RS07005 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) LROSL3_RS07010 ENOG4105GR3 Histidine kinase LROSL3_RS07015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LROSL3_RS07025 ENOG41067VY 50S ribosomal protein L32 LROSL3_RS07030 ENOG4105KNH Nucleic acid-binding protein LROSL3_RS07040 ENOG4108D32 Methyltransferase LROSL3_RS07050 ENOG4108WF2 Metal Dependent Phosphohydrolase LROSL3_RS07055 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) LROSL3_RS07065 ENOG4105CQW ribosome biogenesis GTPase YqeH LROSL3_RS07075 ENOG4105EMS pseudouridine synthase LROSL3_RS07080 ENOG4108UGV hypoxanthine phosphoribosyltransferase LROSL3_RS07095 ENOG4105CKK Glycosyl transferase, family 2 LROSL3_RS07125 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LROSL3_RS07130 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LROSL3_RS07135 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LROSL3_RS07140 ENOG4105VJV 50s ribosomal protein L35 LROSL3_RS07145 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LROSL3_RS07160 ENOG4105C22 threonyL-tRNA synthetase LROSL3_RS07165 ENOG4105C7N Xanthine uracil vitamin C permease LROSL3_RS07180 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) LROSL3_RS07185 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LROSL3_RS07190 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LROSL3_RS07195 ENOG4105C2M dna polymerase I LROSL3_RS07200 ENOG4105HFZ Membrane LROSL3_RS07205 ENOG4105C2C drug resistance transporter, Bcr CflA LROSL3_RS07210 ENOG4105DFU Cell wall formation (By similarity) LROSL3_RS07220 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LROSL3_RS07240 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LROSL3_RS07255 ENOG4105K59 histidine triad (HIT) protein LROSL3_RS07265 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) LROSL3_RS07270 ENOG4105EQI Metal Dependent Phosphohydrolase LROSL3_RS07275 ENOG4106D4I domain protein LROSL3_RS07280 ENOG4107VRP DNA repair exonuclease LROSL3_RS07290 ENOG4105BZ4 penicillin-binding protein LROSL3_RS07295 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LROSL3_RS07300 ENOG4105C75 arginyL-tRNA synthetase LROSL3_RS07330 ENOG4105C26 Dehydrogenase LROSL3_RS07335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LROSL3_RS07375 ENOG4105C87 Aminotransferase class I and II LROSL3_RS07400 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LROSL3_RS07405 ENOG4105EEI dihydropteroate synthase LROSL3_RS07410 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LROSL3_RS07420 ENOG4105EUJ GTP cyclohydrolase i LROSL3_RS07425 ENOG4105EUJ GTP cyclohydrolase i LROSL3_RS07445 ENOG41067S9 phage shock protein C, PspC LROSL3_RS07500 ENOG4105C5I Dehydrogenase LROSL3_RS07505 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LROSL3_RS07510 ENOG4105ZMH deoxynucleoside kinase LROSL3_RS07515 ENOG4107QSE Dipeptidase LROSL3_RS07520 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LROSL3_RS07535 ENOG4105C8T Leucyl-tRNA synthetase LROSL3_RS07540 ENOG410841Q phosphoesterase PA-phosphatase related protein LROSL3_RS07550 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS07555 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LROSL3_RS07565 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LROSL3_RS07570 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LROSL3_RS07625 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS07630 ENOG4105DC7 peptidase M24 LROSL3_RS07655 ENOG4105CPC Aldo Keto reductase LROSL3_RS07665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LROSL3_RS07680 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD LROSL3_RS07685 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) LROSL3_RS07690 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein LROSL3_RS07695 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) LROSL3_RS07705 ENOG4105K63 Thioredoxin LROSL3_RS07710 ENOG4105C98 muts2 protein LROSL3_RS07720 ENOG4105VPH UPF0473 protein LROSL3_RS07725 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LROSL3_RS07730 ENOG4105VBH UPF0297 protein LROSL3_RS07735 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LROSL3_RS07740 ENOG4105C1J atp-dependent rna helicase LROSL3_RS07745 ENOG4105SFS phosphoesterase RecJ domain protein LROSL3_RS07750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LROSL3_RS07755 ENOG4105VIE preprotein translocase, subunit YajC LROSL3_RS07760 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LROSL3_RS07765 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LROSL3_RS07770 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LROSL3_RS07775 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) LROSL3_RS07780 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) LROSL3_RS07790 ENOG4105CZV ABC transporter LROSL3_RS07805 ENOG4105C19 ABC transporter LROSL3_RS07810 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LROSL3_RS07815 ENOG4105CEV competence damage-inducible protein LROSL3_RS07820 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LROSL3_RS07840 ENOG4106TNF Periplasmic binding protein LROSL3_RS07845 ENOG4105CDA abc transporter atp-binding protein LROSL3_RS07850 ENOG4105E5Q amino acid AbC transporter LROSL3_RS07860 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) LROSL3_RS07865 ENOG4105DFF Rod shape-determining protein mreb LROSL3_RS07870 ENOG4105W5Q DNA repair protein (RadC LROSL3_RS07875 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LROSL3_RS07880 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) LROSL3_RS07885 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) LROSL3_RS07900 ENOG41060NJ transcriptional regulator LROSL3_RS07905 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LROSL3_RS07910 ENOG4105C3J Cysteine desulfurase LROSL3_RS07915 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) LROSL3_RS07920 ENOG4108ZGC gaf domain protein LROSL3_RS07935 ENOG4105D1H recombination factor protein RarA LROSL3_RS07980 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) LROSL3_RS07985 ENOG4105CNI cell division protein FtsW LROSL3_RS07995 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) LROSL3_RS08000 ENOG4105DFF Rod shape-determining protein mreb LROSL3_RS08020 ENOG41068JE domain protein LROSL3_RS08205 ENOG4105DVF Cytosine-specific methyltransferase LROSL3_RS08325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LROSL3_RS08335 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) LROSL3_RS08340 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) LROSL3_RS08345 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LROSL3_RS08350 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LROSL3_RS08355 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LROSL3_RS08360 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) LROSL3_RS08375 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LROSL3_RS08380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) LROSL3_RS08385 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LROSL3_RS08390 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LROSL3_RS08395 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LROSL3_RS08400 ENOG4107104 thymidine kinase LROSL3_RS08405 ENOG4105DMS mur ligase LROSL3_RS08410 ENOG4105F1K Glutamine amidotransferase LROSL3_RS08420 ENOG4105C85 amino acid LROSL3_RS08430 ENOG4105DG6 mannose-6-phosphate isomerase LROSL3_RS08435 ENOG4107S1E Beta-lactamase LROSL3_RS08440 ENOG4105R40 Glycine betaine carnitine choline LROSL3_RS08445 ENOG4108HQR Glycine betaine LROSL3_RS08465 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS08470 ENOG4105CPQ Dehydrogenase LROSL3_RS08475 ENOG4105EVU fructokinase LROSL3_RS08530 ENOG4107SUZ Sodium/hydrogen exchanger family LROSL3_RS08550 ENOG4107QYV phosphohexose isomerase LROSL3_RS08555 ENOG4105CSC Glucose uptake protein LROSL3_RS08560 ENOG4105DKQ ROK family LROSL3_RS08570 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LROSL3_RS08595 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LROSL3_RS08610 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LROSL3_RS08615 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LROSL3_RS08620 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LROSL3_RS08635 ENOG4107SUZ Sodium/hydrogen exchanger family LROSL3_RS08645 ENOG4105CGK Exodeoxyribonuclease III LROSL3_RS08650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) LROSL3_RS08660 ENOG4105K8N protein family UPF0079, ATPase LROSL3_RS08665 ENOG4108IJ2 phosphate acetyltransferase LROSL3_RS08670 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) LROSL3_RS08685 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LROSL3_RS08690 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LROSL3_RS08700 ENOG4105XZU Preprotein translocase, subunit SecG LROSL3_RS08705 ENOG4105CMQ Chloride channel LROSL3_RS08710 ENOG4105KBX Transcriptional regulator, TetR family LROSL3_RS08715 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) LROSL3_RS08720 ENOG4105CP7 Triose-phosphate isomerase LROSL3_RS08725 ENOG4105BZA Phosphoglycerate kinase LROSL3_RS08730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LROSL3_RS08740 ENOG4105CHR reductase LROSL3_RS08745 ENOG4105CQ4 Transcriptional regulator LROSL3_RS08750 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase LROSL3_RS08755 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LROSL3_RS08760 ENOG4107RBJ symporter LROSL3_RS08770 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LROSL3_RS08775 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) LROSL3_RS08780 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase LROSL3_RS08875 ENOG4105G5W regulator Fur family LROSL3_RS08880 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS08905 ENOG4105G9B Transcriptional regulator LROSL3_RS08910 ENOG4108TVJ Nitroreductase LROSL3_RS08920 ENOG4105CHR reductase LROSL3_RS08930 ENOG4105DFD Na H antiporter LROSL3_RS08940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LROSL3_RS08945 ENOG4108JJ8 (ABC) transporter LROSL3_RS08950 ENOG4107Z3H Transcriptional regulator, TetR family LROSL3_RS08960 ENOG4105CIE May be required for sporulation (By similarity) LROSL3_RS08965 ENOG4105CHW UPF0052 protein LROSL3_RS08970 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LROSL3_RS08985 ENOG4107R7I amino acid LROSL3_RS08990 ENOG4107R7I amino acid LROSL3_RS08995 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LROSL3_RS09000 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) LROSL3_RS09010 ENOG4105C3M thioredoxin reductase LROSL3_RS09015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LROSL3_RS09020 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase LROSL3_RS09025 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) LROSL3_RS09030 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) LROSL3_RS09035 ENOG41086DT Membrane protein of unknown function LROSL3_RS09045 ENOG4108UTW Plays a role in the regulation of phosphate uptake LROSL3_RS09050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LROSL3_RS09055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LROSL3_RS09060 ENOG4105E2Z phosphate ABC transporter (Permease LROSL3_RS09065 ENOG4105C8U phosphate abc transporter LROSL3_RS09075 ENOG4105BZU Histidine kinase LROSL3_RS09080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LROSL3_RS09090 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LROSL3_RS09100 ENOG41081UC Inherit from COG: Competence protein LROSL3_RS09110 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LROSL3_RS09115 ENOG4105CVA phosphate LROSL3_RS09120 ENOG4105C0X amino acid LROSL3_RS09130 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) LROSL3_RS09135 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) LROSL3_RS09140 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) LROSL3_RS09145 ENOG4105C5H ABC transporter LROSL3_RS09150 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LROSL3_RS09155 ENOG410801F ribosomal-protein-alanine acetyltransferase LROSL3_RS09165 ENOG41072GX Peptidase M22 Glycoprotease LROSL3_RS09170 ENOG4105CMR udp-glucose 4-epimerase LROSL3_RS09180 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LROSL3_RS09185 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) LROSL3_RS09190 ENOG4105FA2 dna polymerase iii LROSL3_RS09195 ENOG4105X0R protein from nitrogen regulatory protein P-II LROSL3_RS09200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LROSL3_RS09205 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LROSL3_RS09215 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LROSL3_RS09220 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LROSL3_RS09225 ENOG4105C6E dna polymerase iii LROSL3_RS09240 ENOG4107Y49 methyltransferase LROSL3_RS09245 ENOG41067VN Glutaredoxin LROSL3_RS09250 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LROSL3_RS09255 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LROSL3_RS09260 ENOG4108URH decarboxylase LROSL3_RS09275 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) LROSL3_RS09280 ENOG4108VZM 50s ribosomal protein L10 LROSL3_RS09285 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) LROSL3_RS09290 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LROSL3_RS09295 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LROSL3_RS09315 ENOG4105C2N RNA methyltransferase TrmH family group 3 LROSL3_RS09320 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) LROSL3_RS09325 ENOG4105C8N cysteinyl-tRNA synthetase LROSL3_RS09330 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LROSL3_RS09340 ENOG4105CTP PilT protein domain protein LROSL3_RS09360 ENOG4105E66 phosphoriboisomerase A LROSL3_RS09380 ENOG4108KGH TRANSCRIPTIONal LROSL3_RS09395 ENOG4105VEQ Cold shock protein LROSL3_RS09405 ENOG4105PGM cation diffusion facilitator family transporter LROSL3_RS09415 ENOG4105CNT hydrolase family 2 LROSL3_RS09455 ENOG4105CS9 pantothenic acid kinase LROSL3_RS09460 ENOG4105EEM helicase LROSL3_RS09465 ENOG4105DQR SNARE associated Golgi LROSL3_RS09475 ENOG4105DPN Oligoendopeptidase f LROSL3_RS09480 ENOG4105DPN Oligoendopeptidase f LROSL3_RS09505 ENOG4108JQ7 (ABC) transporter LROSL3_RS09515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LROSL3_RS09520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LROSL3_RS09540 ENOG4108J59 Extracellular solute-binding protein, family 5 LROSL3_RS09545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LROSL3_RS09555 ENOG4105WT3 Transcriptional regulator LROSL3_RS09620 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LROSL3_RS09625 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LROSL3_RS09630 ENOG4108JQ7 (ABC) transporter LROSL3_RS09645 ENOG4105DA5 (ABC) transporter LROSL3_RS09650 ENOG4105DRP amino acid AbC transporter LROSL3_RS09655 ENOG4105EAD ABC transporter LROSL3_RS09660 ENOG4105CT1 (ABC) transporter LROSL3_RS09680 ENOG4105N80 Ferric uptake regulator, Fur family LROSL3_RS09685 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LROSL3_RS09690 ENOG4105CUB amino acid LROSL3_RS09710 ENOG4108HM4 ABC transporter LROSL3_RS09715 ENOG4105D38 putrescine abc transporter LROSL3_RS09730 ENOG4108J59 Extracellular solute-binding protein, family 5 LROSL3_RS09735 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) LROSL3_RS09770 ENOG41061TZ Short-chain dehydrogenase reductase Sdr LROSL3_RS09795 ENOG4105C5H ABC transporter LROSL3_RS09805 ENOG4105CWM branched-chain amino acid transport system II carrier protein LROSL3_RS09820 ENOG4105CIS alcohol dehydrogenase LROSL3_RS09825 ENOG4105KVH Transcriptional regulator LROSL3_RS09835 ENOG4108IG5 Transcriptional regulator LROSL3_RS09845 ENOG4105C9U ATP-dependent DNA helicase RecQ LROSL3_RS09855 ENOG4105DZW Dipeptidase LROSL3_RS09865 ENOG4105C9K Endothelin-converting enzyme 1 LROSL3_RS09895 ENOG4108Z4K mutator MutT protein LROSL3_RS09900 ENOG4105Y7M Transcriptional regulator, TetR family LROSL3_RS09905 ENOG4105E1F short-chain dehydrogenase reductase LROSL3_RS09935 ENOG4108U05 Transcriptional regulator LROSL3_RS09945 ENOG4108K3A Glutathione S-transferase LROSL3_RS09950 ENOG4108A65 Transcriptional regulator LROSL3_RS09970 ENOG4105C5H ABC transporter LROSL3_RS10000 ENOG4105EPR degv family LROSL3_RS10005 ENOG4106A8V Protein CrcB homolog LROSL3_RS10010 ENOG4106A8V Protein CrcB homolog LROSL3_RS10030 ENOG4105C7J ABC transporter, permease LROSL3_RS10045 ENOG4105K64 Glycosyl transferase, family 2 LROSL3_RS10070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase LROSL3_RS10075 ENOG4105K59 histidine triad (HIT) protein LROSL3_RS10090 ENOG4105VUF Transcriptional regulator LROSL3_RS10095 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LROSL3_RS10110 ENOG4105KVH Transcriptional regulator LROSL3_RS10120 ENOG4105K63 Thioredoxin LROSL3_RS10130 ENOG4107TS3 membrane protein, TerC LROSL3_RS10135 ENOG4108YBP pseudouridine synthase LROSL3_RS10140 ENOG4105C7K acetolactate synthase LROSL3_RS10150 ENOG41067TZ transcriptional regulator, MarR family LROSL3_RS10175 ENOG4107QHE Choloylglycine hydrolase LROSL3_RS10185 ENOG4105KV4 Transcriptional regulator LROSL3_RS10195 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LROSL3_RS10215 ENOG4105C3F Signal peptidase i LROSL3_RS10220 ENOG4105CAY ferredoxin--nadp reductase LROSL3_RS10260 ENOG4105NA0 Transcriptional regulator LROSL3_RS10280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LROSL3_RS10290 ENOG4105C59 p-type ATPase LROSL3_RS10320 ENOG4105DU0 nucleoside hydrolase LROSL3_RS10340 ENOG4108JJB ABC transporter LROSL3_RS10380 ENOG4108U05 Transcriptional regulator LROSL3_RS10390 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase LROSL3_RS10395 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN LROSL3_RS10415 ENOG4105DF9 Lipoate-protein, ligase LROSL3_RS10420 ENOG4107YZX Universal stress protein LROSL3_RS10425 ENOG4105EDW glycosyl transferase, family 39 LROSL3_RS10430 ENOG4105CKK Glycosyl transferase, family 2 LROSL3_RS10435 ENOG4105EPR degv family LROSL3_RS10680 ENOG4108UUM single-stranded DNA-binding protein LROSL3_RS10725 ENOG4108IMY Transcriptional regulator LROSL3_RS10740 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LROSL3_RS10745 ENOG4107QRI Phosphoketolase LROSL3_RS10750 ENOG4108TZY GntR Family Transcriptional Regulator LROSL3_RS10755 ENOG4108Z66 YbaK ebsC protein LROSL3_RS10770 ENOG4108WCX response regulator LROSL3_RS10775 ENOG4105CIG ABC transporter LROSL3_RS10805 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase LROSL3_RS10810 ENOG4105D49 3-dehydroquinate synthase LROSL3_RS10815 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) LROSL3_RS10825 ENOG4105CSR polyphosphate kinase 2 LROSL3_RS10830 ENOG410667J hydrolase LROSL3_RS10860 ENOG4105C0A alcohol dehydrogenase LROSL3_RS10865 ENOG4105ZT7 DNA-entry nuclease LROSL3_RS10885 ENOG410902V Modulates RecA activity (By similarity) LROSL3_RS10895 ENOG41075D4 Aminoglycoside 6-adenylyltransferase LROSL3_RS10900 ENOG4107Y70 Heat shock protein LROSL3_RS10910 ENOG4105C37 (CBS) domain LROSL3_RS10930 ENOG410605W Major Facilitator LROSL3_RS10950 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) LROSL3_RS10955 ENOG4105C7N Xanthine uracil vitamin C permease LROSL3_RS10960 ENOG4105CPN adenine deaminase LROSL3_RS11060 ENOG4108JJ8 (ABC) transporter LROSL3_RS11070 ENOG4105C0R drug resistance transporter emrb qaca subfamily LROSL3_RS11085 ENOG4105CJ1 ABC, transporter LROSL3_RS11105 ENOG4105C98 muts2 protein LROSL3_RS11125 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LROSL3_RS11135 ENOG4105EYF MMPL domain protein LROSL3_RS11145 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LROSL3_RS11215 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LROSL3_RS11270 ENOG4107QPK )-transporter LROSL3_RS11275 ENOG4107ZGM malolactic fermentation system LROSL3_RS11285 ENOG4105EPR degv family LROSL3_RS11295 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation LROSL3_RS11300 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination LROSL3_RS11330 ENOG4108A65 Transcriptional regulator LROSL3_RS11335 ENOG4107XZQ multidrug resistance protein LROSL3_RS11340 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LROSL3_RS11345 ENOG4105CHM Aminotransferase LROSL3_RS11355 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LROSL3_RS11365 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) LROSL3_RS11370 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LROSL3_RS11375 ENOG4105CFH Aspartokinase LROSL3_RS11380 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) LROSL3_RS11385 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LROSL3_RS11395 ENOG4105BZ1 (ABC) transporter LROSL3_RS11400 ENOG4105BZ1 (ABC) transporter LROSL3_RS11455 ENOG4105E90 ABC transporter LROSL3_RS11460 ENOG4108IJ8 ABC transporter LROSL3_RS11480 ENOG4108IJ9 (ABC) transporter LROSL3_RS11490 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component LROSL3_RS11505 ENOG4105CGH 5'-nucleotidase LROSL3_RS11510 ENOG4105CEP NADH dehydrogenase LROSL3_RS11540 ENOG4105C3F Signal peptidase i LROSL3_RS11545 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) LROSL3_RS11565 ENOG4106432 Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) LROSL3_RS11580 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria LROSL3_RS11595 ENOG4107R8N Glycosyl transferase, family 2 LROSL3_RS11630 ENOG4105BZ1 (ABC) transporter LROSL3_RS11640 ENOG4107PP3 Acetylornithine deacetylase LROSL3_RS11650 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LROSL3_RS11655 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) LROSL3_RS11665 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) LROSL3_RS11670 ENOG4108UZ3 Transporter LROSL3_RS11755 ENOG4108ZHR arsR family transcriptional regulator LROSL3_RS11760 ENOG4105CJ1 ABC, transporter LROSL3_RS11765 ENOG4105HAC ABC-2 type transporter LROSL3_RS11775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LROSL3_RS11780 ENOG4105E5D amino acid LROSL3_RS11830 ENOG4108MTT Glutamate-rich protein grpB LROSL3_RS11865 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) LROSL3_RS11870 ENOG4105C0H protease LROSL3_RS11880 ENOG4105EMU Dehydrogenase LROSL3_RS11885 ENOG4105KVH Transcriptional regulator LROSL3_RS11890 ENOG4105CSC Glucose uptake protein LROSL3_RS11895 ENOG4107EXU Short-chain dehydrogenase reductase Sdr LROSL3_RS11900 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LROSL3_RS11910 ENOG4105KVH Transcriptional regulator LROSL3_RS11940 ENOG4105Q2H domain protein LROSL3_RS11955 ENOG4105BZU Histidine kinase LROSL3_RS11960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LROSL3_RS12000 ENOG4108UW5 maltose o-acetyltransferase LROSL3_RS12005 ENOG4105ETE Transcriptional regulator (LacI family LROSL3_RS12050 ENOG4105WH1 Two component transcriptional regulator luxr family LROSL3_RS12070 ENOG4105DIW FeS assembly protein SUFB LROSL3_RS12075 ENOG4108UNV SUF system FeS assembly protein, NifU family LROSL3_RS12080 ENOG4105C9B Cysteine desulfurase LROSL3_RS12085 ENOG4105JRK feS assembly protein SufD LROSL3_RS12090 ENOG4105C3K feS assembly ATPase SufC LROSL3_RS12110 ENOG4107SJI Dehydrogenase LROSL3_RS12115 ENOG4105BZ8 glutamate synthase LROSL3_RS12120 ENOG4105CPN adenine deaminase LROSL3_RS12130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LROSL3_RS12135 ENOG4108I5D sulfate abc transporter LROSL3_RS12140 ENOG4105F38 ABC transporter, permease LROSL3_RS12145 ENOG4105CHM Aminotransferase LROSL3_RS12150 ENOG4105C5I Dehydrogenase LROSL3_RS12170 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps LROSL3_RS12175 ENOG4107RGD Major Facilitator superfamily LROSL3_RS12180 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) LROSL3_RS12185 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LROSL3_RS12190 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) LROSL3_RS12200 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LROSL3_RS12210 ENOG4105X1N Glycosyl transferase family 8 LROSL3_RS12225 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LROSL3_RS12230 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LROSL3_RS12240 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LROSL3_RS12255 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins LROSL3_RS12260 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) LROSL3_RS12265 ENOG4105VG0 50S ribosomal protein l34 LROSL3_RS12280 ENOG4107BMA Transglycosylase associated protein LROSL3_RS12295 ENOG4107QJE Chromosome Partitioning Protein LROSL3_RS12300 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LROSL3_RS12355 ENOG4105DZR Type I site-specific deoxyribonuclease LROSL3_RS12370 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LROSL3_RS12395 ENOG4107BMA Transglycosylase associated protein LROSL3_RS12425 ENOG4105HUF DNA protection during starvation protein