locus-tag	class	description
LROSL3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LROSL3_RS00010	COG0592	DNA-directed DNA polymerase activity
LROSL3_RS00015	COG2501	S4 domain
LROSL3_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LROSL3_RS00025	COG0187	DNA topoisomerase II activity
LROSL3_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LROSL3_RS00040	COG0393	Putative heavy-metal-binding
LROSL3_RS00045	COG0360	Binds together with S18 to 16S ribosomal RNA
LROSL3_RS00050	COG0629	single-stranded DNA binding
LROSL3_RS00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LROSL3_RS00065	COG0359	binds to the 23S rRNA
LROSL3_RS00070	COG0305	Participates in initiation and elongation during chromosome replication
LROSL3_RS00080	COG2814	Major facilitator Superfamily
LROSL3_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS00105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LROSL3_RS00135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LROSL3_RS00150	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS00195	COG2814	Major facilitator Superfamily
LROSL3_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS00285	COG0477	Major facilitator Superfamily
LROSL3_RS00290	COG1114	Component of the transport system for branched-chain amino acids
LROSL3_RS00295	COG1309	transcriptional regulator
LROSL3_RS00310	COG0693	protein deglycase activity
LROSL3_RS00320	COG0477	Major facilitator Superfamily
LROSL3_RS00335	COG2017	converts alpha-aldose to the beta-anomer
LROSL3_RS00350	COG1609	Transcriptional regulator
LROSL3_RS00360	COG2814	Major facilitator Superfamily
LROSL3_RS00385	COG0698	ribose 5-phosphate isomerase
LROSL3_RS00390	COG4989	oxidoreductase activity
LROSL3_RS00395	COG0789	Transcriptional regulator
LROSL3_RS00415	COG0419	ATPase involved in DNA repair
LROSL3_RS00425	COG4335	DNA alkylation repair
LROSL3_RS00430	COG2378	regulation of single-species biofilm formation
LROSL3_RS00445	COG1695	Transcriptional regulator
LROSL3_RS00460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LROSL3_RS00470	COG1511	domain protein
LROSL3_RS00475	COG0477	Major facilitator Superfamily
LROSL3_RS00490	COG2249	NAD(P)H dehydrogenase (quinone) activity
LROSL3_RS00495	COG0540	Belongs to the ATCase OTCase family
LROSL3_RS00505	COG0505	Belongs to the CarA family
LROSL3_RS00510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LROSL3_RS00520	COG4115	mRNA cleavage
LROSL3_RS00525	COG0697	spore germination
LROSL3_RS00545	COG1472	Belongs to the glycosyl hydrolase 3 family
LROSL3_RS00560	COG4166	transmembrane transport
LROSL3_RS00575	COG4555	ABC transporter
LROSL3_RS00590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LROSL3_RS00590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LROSL3_RS00600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LROSL3_RS00600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LROSL3_RS00605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LROSL3_RS00610	COG0386	Belongs to the glutathione peroxidase family
LROSL3_RS00615	COG2261	transglycosylase associated protein
LROSL3_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS00655	COG1609	Transcriptional regulator
LROSL3_RS00675	COG0488	(ABC) transporter
LROSL3_RS00685	COG1053	succinate dehydrogenase
LROSL3_RS00705	COG0765	amino acid transport
LROSL3_RS00710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LROSL3_RS00715	COG1733	regulation of RNA biosynthetic process
LROSL3_RS00720	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS00755	COG0366	Alpha amylase catalytic
LROSL3_RS00775	COG2814	Major facilitator Superfamily
LROSL3_RS00780	COG0004	ammonium transporteR
LROSL3_RS00805	COG0477	Major facilitator Superfamily
LROSL3_RS00810	COG0583	DNA-binding transcription factor activity
LROSL3_RS00830	COG0024	Methionine aminopeptidase
LROSL3_RS00835	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS00850	COG0039	L-malate dehydrogenase activity
LROSL3_RS00855	COG0114	fumarate hydratase activity
LROSL3_RS00860	COG0471	metal ion transport
LROSL3_RS00875	COG0667	Aldo Keto reductase
LROSL3_RS00885	COG2390	Transcriptional regulator
LROSL3_RS00895	COG3052	prosthetic group binding
LROSL3_RS00910	COG0583	DNA-binding transcription factor activity
LROSL3_RS00915	COG1053	succinate dehydrogenase
LROSL3_RS00920	COG0583	DNA-binding transcription factor activity
LROSL3_RS00925	COG0583	DNA-binding transcription factor activity
LROSL3_RS00930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LROSL3_RS00935	COG0163	prenyltransferase activity
LROSL3_RS00945	COG1668	transmembrane transport
LROSL3_RS00950	COG4152	abc transporter atp-binding protein
LROSL3_RS00955	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS00965	COG2814	Major facilitator Superfamily
LROSL3_RS00980	COG1113	amino acid transport
LROSL3_RS00990	COG3479	Phenolic acid decarboxylase
LROSL3_RS00995	COG1695	Transcriptional regulator
LROSL3_RS01005	COG0277	FAD linked oxidase domain protein
LROSL3_RS01030	COG0730	response to heat
LROSL3_RS01035	COG0446	pyridine nucleotide-disulphide oxidoreductase
LROSL3_RS01040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LROSL3_RS01045	COG1216	Glycosyl transferase, family 2
LROSL3_RS01055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LROSL3_RS01060	COG0738	Major facilitator superfamily
LROSL3_RS01065	COG0710	3-dehydroquinate dehydratase activity
LROSL3_RS01075	COG0431	NADPH-dependent FMN reductase
LROSL3_RS01075	COG1053	succinate dehydrogenase
LROSL3_RS01075	COG3976	FMN-binding domain protein
LROSL3_RS01130	COG2814	Major facilitator Superfamily
LROSL3_RS01135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LROSL3_RS01145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LROSL3_RS01150	COG0537	adenosine 5'-monophosphoramidase activity
LROSL3_RS01170	COG0583	DNA-binding transcription factor activity
LROSL3_RS01210	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS01225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LROSL3_RS01230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LROSL3_RS01230	COG1522	sequence-specific DNA binding
LROSL3_RS01235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LROSL3_RS01240	COG0135	phosphoribosylanthranilate isomerase activity
LROSL3_RS01255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LROSL3_RS01280	COG3940	Belongs to the glycosyl hydrolase 43 family
LROSL3_RS01290	COG2017	converts alpha-aldose to the beta-anomer
LROSL3_RS01315	COG2160	L-arabinose isomerase activity
LROSL3_RS01320	COG0110	maltose O-acetyltransferase activity
LROSL3_RS01325	COG1136	(ABC) transporter
LROSL3_RS01330	COG0577	efflux transmembrane transporter activity
LROSL3_RS01340	COG0667	Aldo Keto reductase
LROSL3_RS01370	COG3152	Membrane
LROSL3_RS01400	COG0668	transmembrane transport
LROSL3_RS01430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LROSL3_RS01445	COG1957	nucleoside hydrolase
LROSL3_RS01485	COG2814	Major facilitator Superfamily
LROSL3_RS01505	COG1045	serine acetyltransferase
LROSL3_RS01510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LROSL3_RS01530	COG1194	a g-specific adenine glycosylase
LROSL3_RS01535	COG0328	RNA-DNA hybrid ribonuclease activity
LROSL3_RS01560	COG2226	methyltransferase
LROSL3_RS01565	COG3275	phosphorelay sensor kinase activity
LROSL3_RS01580	COG1346	cytolysis
LROSL3_RS01590	COG1346	cytolysis
LROSL3_RS01600	COG0546	phosphoglycolate phosphatase activity
LROSL3_RS01630	COG0308	aminopeptidase N
LROSL3_RS01650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LROSL3_RS01670	COG2826	transposase and inactivated derivatives, IS30 family
LROSL3_RS01685	COG2365	Tyrosine phosphatase family
LROSL3_RS01705	COG2910	NAD(P)H-binding
LROSL3_RS01715	COG2814	Major facilitator Superfamily
LROSL3_RS01725	COG0589	response to stress
LROSL3_RS01730	COG1914	H( )-stimulated, divalent metal cation uptake system
LROSL3_RS01735	COG1230	cation diffusion facilitator family transporter
LROSL3_RS01740	COG0776	regulation of translation
LROSL3_RS01765	COG0561	phosphatase activity
LROSL3_RS01770	COG2807	transmembrane transport
LROSL3_RS01775	COG2226	methyltransferase
LROSL3_RS01790	COG3759	membrane
LROSL3_RS01800	COG0586	Pfam SNARE associated Golgi protein
LROSL3_RS01810	COG2814	Major facilitator Superfamily
LROSL3_RS01820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LROSL3_RS01825	COG4619	ABC transporter
LROSL3_RS01830	COG0390	transport system, permease component
LROSL3_RS01865	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS01875	COG1136	(ABC) transporter
LROSL3_RS01875	COG0577	efflux transmembrane transporter activity
LROSL3_RS01890	COG0095	Lipoate-protein ligase
LROSL3_RS01900	COG0583	DNA-binding transcription factor activity
LROSL3_RS01905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LROSL3_RS01915	COG0357	Ribosomal RNA small subunit methyltransferase G
LROSL3_RS01925	COG1192	Involved in chromosome partitioning
LROSL3_RS01930	COG1475	DNA binding
LROSL3_RS01935	COG4481	Protein conserved in bacteria
LROSL3_RS01940	COG0012	GTP binding
LROSL3_RS01960	COG1511	domain protein
LROSL3_RS01960	COG1511	domain protein
LROSL3_RS01970	COG0582	viral genome integration into host DNA
LROSL3_RS01990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LROSL3_RS02000	COG0628	permease
LROSL3_RS02005	COG0588	phosphoglycerate mutase activity
LROSL3_RS02025	COG2378	regulation of single-species biofilm formation
LROSL3_RS02030	COG0534	Mate efflux family protein
LROSL3_RS02035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LROSL3_RS02060	COG3775	system Galactitol-specific IIC component
LROSL3_RS02065	COG3414	Phosphotransferase system galactitol-specific IIB component
LROSL3_RS02080	COG1131	(ABC) transporter
LROSL3_RS02110	COG0702	epimerase
LROSL3_RS02115	COG0300	oxidoreductase activity
LROSL3_RS02130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LROSL3_RS02135	COG4166	transmembrane transport
LROSL3_RS02140	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LROSL3_RS02145	COG0596	Alpha beta hydrolase
LROSL3_RS02150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LROSL3_RS02155	COG1942	4-Oxalocrotonate Tautomerase
LROSL3_RS02165	COG0583	DNA-binding transcription factor activity
LROSL3_RS02180	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS02185	COG0110	maltose O-acetyltransferase activity
LROSL3_RS02195	COG4221	oxidoreductase activity
LROSL3_RS02215	COG1979	alcohol dehydrogenase
LROSL3_RS02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LROSL3_RS02225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LROSL3_RS02245	COG0702	epimerase
LROSL3_RS02250	COG1959	2 iron, 2 sulfur cluster binding
LROSL3_RS02270	COG2217	Heavy metal translocating P-type atpase
LROSL3_RS02280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LROSL3_RS02285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LROSL3_RS02290	COG0110	maltose O-acetyltransferase activity
LROSL3_RS02295	COG0640	Transcriptional regulator
LROSL3_RS02300	COG0604	alcohol dehydrogenase
LROSL3_RS02300	COG3321	synthase
LROSL3_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS02320	COG1063	alcohol dehydrogenase
LROSL3_RS02345	COG1302	Protein conserved in bacteria
LROSL3_RS02360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LROSL3_RS02390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LROSL3_RS02405	COG1902	pentaerythritol trinitrate reductase activity
LROSL3_RS02415	COG1131	(ABC) transporter
LROSL3_RS02425	COG1309	transcriptional regulator
LROSL3_RS02430	COG1846	Transcriptional regulator
LROSL3_RS02435	COG1132	(ABC) transporter
LROSL3_RS02440	COG0534	Mate efflux family protein
LROSL3_RS02450	COG1131	(ABC) transporter
LROSL3_RS02470	COG1113	amino acid transport
LROSL3_RS02475	COG2217	Heavy metal translocating P-type atpase
LROSL3_RS02500	COG0242	peptide deformylase activity
LROSL3_RS02515	COG2252	PERMEase
LROSL3_RS02550	COG0105	UTP biosynthetic process
LROSL3_RS02565	COG0446	pyridine nucleotide-disulphide oxidoreductase
LROSL3_RS02570	COG4720	Psort location CytoplasmicMembrane, score
LROSL3_RS02575	COG1122	ATPase activity
LROSL3_RS02580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LROSL3_RS02590	COG0561	phosphatase activity
LROSL3_RS02595	COG1609	Transcriptional regulator
LROSL3_RS02615	COG3118	belongs to the thioredoxin family
LROSL3_RS02625	COG1937	Protein conserved in bacteria
LROSL3_RS02635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LROSL3_RS02640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LROSL3_RS02685	COG1335	isochorismatase
LROSL3_RS02700	COG1132	(ABC) transporter
LROSL3_RS02720	COG0110	maltose O-acetyltransferase activity
LROSL3_RS02795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LROSL3_RS02805	COG1125	glycine betaine transport
LROSL3_RS02805	COG0517	IMP dehydrogenase activity
LROSL3_RS02820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LROSL3_RS02835	COG3973	AAA domain
LROSL3_RS02860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LROSL3_RS02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LROSL3_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LROSL3_RS02880	COG0084	hydrolase, TatD family'
LROSL3_RS02885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LROSL3_RS02890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LROSL3_RS02895	COG4466	Protein conserved in bacteria
LROSL3_RS02900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LROSL3_RS02920	COG1121	(ABC) transporter
LROSL3_RS02930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LROSL3_RS02935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LROSL3_RS02940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LROSL3_RS02955	COG0561	phosphatase activity
LROSL3_RS02960	COG1078	dGTPase activity
LROSL3_RS02965	COG0095	Lipoate-protein ligase
LROSL3_RS02975	COG3343	RNA polymerase activity
LROSL3_RS02980	COG0504	CTP synthase activity
LROSL3_RS02985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LROSL3_RS02990	COG0254	rRNA binding
LROSL3_RS02995	COG2814	Major facilitator Superfamily
LROSL3_RS03000	COG2814	Major facilitator Superfamily
LROSL3_RS03005	COG3764	Sortase (surface protein transpeptidase)
LROSL3_RS03010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LROSL3_RS03015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LROSL3_RS03025	COG0736	holo-[acyl-carrier-protein] synthase activity
LROSL3_RS03030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LROSL3_RS03040	COG2337	Toxic component of a toxin-antitoxin (TA) module
LROSL3_RS03050	COG0039	L-malate dehydrogenase activity
LROSL3_RS03055	COG0193	aminoacyl-tRNA hydrolase activity
LROSL3_RS03060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LROSL3_RS03065	COG2244	polysaccharide biosynthetic process
LROSL3_RS03070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LROSL3_RS03080	COG1098	S1 RNA binding domain
LROSL3_RS03085	COG0037	tRNA processing
LROSL3_RS03100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LROSL3_RS03105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LROSL3_RS03110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LROSL3_RS03140	COG3104	oligopeptide transport
LROSL3_RS03160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LROSL3_RS03165	COG4946	Tricorn protease homolog
LROSL3_RS03165	COG1506	peptidase
LROSL3_RS03165	COG0823	Involved in the tonB-independent uptake of proteins
LROSL3_RS03170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LROSL3_RS03170	COG2169	Transcriptional regulator
LROSL3_RS03175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LROSL3_RS03185	COG2188	Transcriptional regulator
LROSL3_RS03190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LROSL3_RS03210	COG3091	SprT-like family
LROSL3_RS03215	COG0628	permease
LROSL3_RS03250	COG4221	oxidoreductase activity
LROSL3_RS03255	COG1316	TRANSCRIPTIONal
LROSL3_RS03260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LROSL3_RS03265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LROSL3_RS03285	COG3715	PTS system
LROSL3_RS03290	COG3716	PTS system mannose fructose sorbose family IID component
LROSL3_RS03310	COG0588	phosphoglycerate mutase activity
LROSL3_RS03315	COG5002	protein histidine kinase activity
LROSL3_RS03320	COG0745	RESPONSE REGULATOR receiver
LROSL3_RS03355	COG1959	2 iron, 2 sulfur cluster binding
LROSL3_RS03360	COG0833	amino acid
LROSL3_RS03365	COG1428	Deoxynucleoside kinase
LROSL3_RS03370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LROSL3_RS03400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LROSL3_RS03415	COG0697	spore germination
LROSL3_RS03425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LROSL3_RS03430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LROSL3_RS03435	COG4463	regulation of RNA biosynthetic process
LROSL3_RS03440	COG0542	response to heat
LROSL3_RS03445	COG2826	transposase and inactivated derivatives, IS30 family
LROSL3_RS03455	COG0085	RNA polymerase activity
LROSL3_RS03460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LROSL3_RS03465	COG4716	Myosin-crossreactive antigen
LROSL3_RS03470	COG0640	Transcriptional regulator
LROSL3_RS03480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LROSL3_RS03485	COG0049	tRNA binding
LROSL3_RS03490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LROSL3_RS03500	COG1335	isochorismatase
LROSL3_RS03505	COG0051	transcription antitermination factor activity, RNA binding
LROSL3_RS03510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LROSL3_RS03520	COG0089	rRNA binding
LROSL3_RS03525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LROSL3_RS03530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LROSL3_RS03535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LROSL3_RS03540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LROSL3_RS03545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LROSL3_RS03550	COG0255	Belongs to the universal ribosomal protein uL29 family
LROSL3_RS03555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LROSL3_RS03560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LROSL3_RS03565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LROSL3_RS03570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LROSL3_RS03575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LROSL3_RS03580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LROSL3_RS03585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LROSL3_RS03590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LROSL3_RS03595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LROSL3_RS03600	COG1841	ribosomal large subunit assembly
LROSL3_RS03605	COG0200	Binds to the 23S rRNA
LROSL3_RS03625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LROSL3_RS03630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LROSL3_RS03635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LROSL3_RS03640	COG0202	RNA polymerase activity
LROSL3_RS03645	COG0203	ribosomal protein L17
LROSL3_RS03655	COG1122	ATPase activity
LROSL3_RS03670	COG0101	tRNA pseudouridine synthase activity
LROSL3_RS03675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LROSL3_RS03715	COG0531	amino acid
LROSL3_RS03720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LROSL3_RS03725	COG1271	oxidase subunit
LROSL3_RS03730	COG1294	oxidase, subunit
LROSL3_RS03735	COG4988	ABC transporter
LROSL3_RS03740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LROSL3_RS03765	COG0142	geranyltranstransferase activity
LROSL3_RS03775	COG1705	Flagellar rod assembly protein muramidase FlgJ
LROSL3_RS03790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LROSL3_RS03795	COG4851	CamS sex pheromone cAM373 precursor
LROSL3_RS03810	COG0154	amidase activity
LROSL3_RS03815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LROSL3_RS03820	COG1597	lipid kinase activity
LROSL3_RS03825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LROSL3_RS03830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LROSL3_RS03835	COG0646	methionine synthase
LROSL3_RS03835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LROSL3_RS03845	COG1476	TRANSCRIPTIONal
LROSL3_RS03875	COG1737	Transcriptional regulator
LROSL3_RS03915	COG0673	inositol 2-dehydrogenase activity
LROSL3_RS03920	COG0513	Belongs to the DEAD box helicase family
LROSL3_RS03925	COG1942	4-Oxalocrotonate Tautomerase
LROSL3_RS03940	COG0351	phosphomethylpyrimidine kinase
LROSL3_RS03945	COG1846	Transcriptional regulator
LROSL3_RS03960	COG2246	polysaccharide biosynthetic process
LROSL3_RS03970	COG2246	polysaccharide biosynthetic process
LROSL3_RS03985	COG0716	FMN binding
LROSL3_RS03990	COG4750	Nucleotidyl transferase
LROSL3_RS03995	COG0697	spore germination
LROSL3_RS04005	COG2244	polysaccharide biosynthetic process
LROSL3_RS04020	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS04025	COG0562	UDP-galactopyranose mutase
LROSL3_RS04030	COG3557	Belongs to the UPF0374 family
LROSL3_RS04035	COG0628	permease
LROSL3_RS04040	COG1705	Flagellar rod assembly protein muramidase FlgJ
LROSL3_RS04050	COG1216	Glycosyl transferase, family 2
LROSL3_RS04055	COG3475	LICD family
LROSL3_RS04105	COG0463	Glycosyl transferase, family 2
LROSL3_RS04110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LROSL3_RS04115	COG0501	Belongs to the peptidase M48B family
LROSL3_RS04120	COG1704	LemA family
LROSL3_RS04125	COG0456	acetyltransferase
LROSL3_RS04145	COG2801	Transposase and inactivated derivatives
LROSL3_RS04155	COG3591	Belongs to the peptidase S1B family
LROSL3_RS04160	COG0542	response to heat
LROSL3_RS04190	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS04195	COG0438	transferase activity, transferring glycosyl groups
LROSL3_RS04210	COG1368	sulfuric ester hydrolase activity
LROSL3_RS04340	COG0217	transcriptional regulatory protein
LROSL3_RS04345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LROSL3_RS04350	COG4537	Required for transformation and DNA binding
LROSL3_RS04375	COG0827	DNA restriction-modification system
LROSL3_RS04380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LROSL3_RS04385	COG1113	amino acid transport
LROSL3_RS04395	COG4470	Protein conserved in bacteria
LROSL3_RS04400	COG0647	UMP catabolic process
LROSL3_RS04410	COG0586	Pfam SNARE associated Golgi protein
LROSL3_RS04415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LROSL3_RS04420	COG0539	negative regulation of cytoplasmic translation
LROSL3_RS04550	COG1234	tRNA 3'-trailer cleavage
LROSL3_RS04555	COG1393	Belongs to the ArsC family
LROSL3_RS04560	COG4862	establishment of competence for transformation
LROSL3_RS04580	COG1164	Oligoendopeptidase f
LROSL3_RS04590	COG2357	RelA SpoT domain protein
LROSL3_RS04595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LROSL3_RS04600	COG0564	pseudouridine synthase activity
LROSL3_RS04605	COG3142	Participates in the control of copper homeostasis
LROSL3_RS04610	COG2706	6-phosphogluconolactonase activity
LROSL3_RS04615	COG0628	permease
LROSL3_RS04625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LROSL3_RS04630	COG1674	ftsk spoiiie
LROSL3_RS04650	COG2001	Belongs to the MraZ family
LROSL3_RS04655	COG0275	rRNA processing
LROSL3_RS04670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LROSL3_RS04675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LROSL3_RS04680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LROSL3_RS04685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LROSL3_RS04700	COG1799	cell septum assembly
LROSL3_RS04705	COG0762	integral membrane protein
LROSL3_RS04715	COG3599	regulation of cell shape
LROSL3_RS04720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LROSL3_RS04735	COG1278	Cold shock
LROSL3_RS04740	COG0494	nUDIX hydrolase
LROSL3_RS04750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LROSL3_RS04755	COG1104	cysteine desulfurase activity
LROSL3_RS04765	COG0482	sulfurtransferase activity
LROSL3_RS04770	COG0406	alpha-ribazole phosphatase activity
LROSL3_RS04780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LROSL3_RS04790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LROSL3_RS04795	COG0667	Aldo Keto reductase
LROSL3_RS04805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LROSL3_RS04810	COG2011	ABC-type metal ion transport system permease component
LROSL3_RS04835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LROSL3_RS04840	COG0402	S-adenosylhomocysteine deaminase activity
LROSL3_RS04850	COG3527	Alpha-acetolactate decarboxylase
LROSL3_RS04855	COG0561	phosphatase activity
LROSL3_RS04865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LROSL3_RS04875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LROSL3_RS04880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LROSL3_RS04885	COG0813	purine-nucleoside phosphorylase activity
LROSL3_RS04890	COG2390	Transcriptional regulator
LROSL3_RS04920	COG2030	dehydratase
LROSL3_RS04925	COG1024	Enoyl-CoA hydratase
LROSL3_RS04930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LROSL3_RS04935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LROSL3_RS04945	COG0583	DNA-binding transcription factor activity
LROSL3_RS04950	COG1072	(Pantothenic acid kinase))
LROSL3_RS04955	COG2267	carboxylic ester hydrolase activity
LROSL3_RS04960	COG1393	Belongs to the ArsC family
LROSL3_RS04965	COG1609	Transcriptional regulator
LROSL3_RS04975	COG0583	DNA-binding transcription factor activity
LROSL3_RS04980	COG1053	succinate dehydrogenase
LROSL3_RS04995	COG1869	D-ribose catabolic process
LROSL3_RS05000	COG0738	Major facilitator superfamily
LROSL3_RS05020	COG1288	antiporter activity
LROSL3_RS05030	COG2235	arginine
LROSL3_RS05045	COG0436	Aminotransferase
LROSL3_RS05060	COG1438	arginine binding
LROSL3_RS05065	COG0833	amino acid
LROSL3_RS05070	COG0018	arginyl-trna synthetase
LROSL3_RS05080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LROSL3_RS05085	COG0583	DNA-binding transcription factor activity
LROSL3_RS05100	COG2706	6-phosphogluconolactonase activity
LROSL3_RS05110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LROSL3_RS05115	COG0531	amino acid
LROSL3_RS05120	COG2957	Belongs to the agmatine deiminase family
LROSL3_RS05205	COG1609	Transcriptional regulator
LROSL3_RS05215	COG0531	amino acid
LROSL3_RS05220	COG0351	phosphomethylpyrimidine kinase
LROSL3_RS05235	COG4475	Protein of unknown function (DUF436)
LROSL3_RS05240	COG4720	Psort location CytoplasmicMembrane, score
LROSL3_RS05245	COG0124	histidyl-tRNA synthetase
LROSL3_RS05265	COG4475	Protein of unknown function (DUF436)
LROSL3_RS05270	COG4720	Psort location CytoplasmicMembrane, score
LROSL3_RS05280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LROSL3_RS05285	COG4565	transcriptional regulatory protein
LROSL3_RS05290	COG3290	protein histidine kinase activity
LROSL3_RS05295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LROSL3_RS05300	COG2267	carboxylic ester hydrolase activity
LROSL3_RS05325	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LROSL3_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS05350	COG0791	NLP P60 protein
LROSL3_RS05365	COG1597	lipid kinase activity
LROSL3_RS05370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LROSL3_RS05390	COG0242	peptide deformylase activity
LROSL3_RS05420	COG4476	Belongs to the UPF0223 family
LROSL3_RS05425	COG0483	inositol monophosphate 1-phosphatase activity
LROSL3_RS05435	COG0772	Belongs to the SEDS family
LROSL3_RS05440	COG4471	UPF0298 protein
LROSL3_RS05445	COG0742	ribosomal rna small subunit methyltransferase
LROSL3_RS05450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LROSL3_RS05455	COG3480	Lon protease (S16) C-terminal proteolytic domain
LROSL3_RS05460	COG1596	polysaccharide export
LROSL3_RS05460	COG1555	photosystem II stabilization
LROSL3_RS05465	COG2131	deaminase
LROSL3_RS05475	COG1466	dna polymerase III delta subunit
LROSL3_RS05480	COG0268	Binds directly to 16S ribosomal RNA
LROSL3_RS05485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LROSL3_RS05500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LROSL3_RS05505	COG0544	peptidyl-prolyl cis-trans isomerase activity
LROSL3_RS05510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LROSL3_RS05515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LROSL3_RS05530	COG0765	amino acid transport
LROSL3_RS05535	COG1126	abc transporter atp-binding protein
LROSL3_RS05540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LROSL3_RS05545	COG0322	excinuclease ABC activity
LROSL3_RS05550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LROSL3_RS05555	COG2755	lipolytic protein G-D-S-L family
LROSL3_RS05555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LROSL3_RS05565	COG1234	tRNA 3'-trailer cleavage
LROSL3_RS05570	COG0300	oxidoreductase activity
LROSL3_RS05575	COG5416	Lipopolysaccharide assembly protein A domain
LROSL3_RS05580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LROSL3_RS05580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LROSL3_RS05595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LROSL3_RS05605	COG3425	synthase
LROSL3_RS05625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LROSL3_RS05630	COG4224	UPF0291 protein
LROSL3_RS05635	COG3763	UPF0154 protein
LROSL3_RS05640	COG1132	(ABC) transporter
LROSL3_RS05645	COG1132	(ABC) transporter
LROSL3_RS05650	COG0204	Acyl-transferase
LROSL3_RS05655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LROSL3_RS05660	COG2827	Endonuclease containing a URI domain
LROSL3_RS05665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LROSL3_RS05675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LROSL3_RS05680	COG0528	UMP kinase activity
LROSL3_RS05690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LROSL3_RS05695	COG4589	Belongs to the CDS family
LROSL3_RS05700	COG0750	zinc metalloprotease
LROSL3_RS05705	COG0442	prolyl-tRNA aminoacylation
LROSL3_RS05710	COG2176	DNA-directed DNA polymerase activity
LROSL3_RS05715	COG0346	lactoylglutathione lyase activity
LROSL3_RS05725	COG0195	Participates in both transcription termination and antitermination
LROSL3_RS05730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LROSL3_RS05740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LROSL3_RS05740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LROSL3_RS05745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LROSL3_RS05750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LROSL3_RS05755	COG0196	riboflavin kinase activity
LROSL3_RS05760	COG1420	regulation of RNA biosynthetic process
LROSL3_RS05765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LROSL3_RS05770	COG0443	Heat shock 70 kDa protein
LROSL3_RS05775	COG0484	heat shock protein binding
LROSL3_RS05780	COG0481	GTPase activity
LROSL3_RS05790	COG0604	alcohol dehydrogenase
LROSL3_RS05795	COG2264	protein methyltransferase activity
LROSL3_RS05800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LROSL3_RS05810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LROSL3_RS05815	COG1490	D-aminoacyl-tRNA deacylase activity
LROSL3_RS05820	COG3001	Fructosamine kinase
LROSL3_RS05825	COG0860	N-Acetylmuramoyl-L-alanine amidase
LROSL3_RS05830	COG0124	histidyl-tRNA synthetase
LROSL3_RS05835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LROSL3_RS05845	COG3976	FMN-binding domain protein
LROSL3_RS05845	COG1053	succinate dehydrogenase
LROSL3_RS05845	COG0431	NADPH-dependent FMN reductase
LROSL3_RS05855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LROSL3_RS05860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LROSL3_RS05865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LROSL3_RS05870	COG1610	YqeY-like protein
LROSL3_RS05875	COG1702	phosphate starvation-inducible protein PhoH
LROSL3_RS05880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LROSL3_RS05885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LROSL3_RS05890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LROSL3_RS05895	COG1381	Involved in DNA repair and RecF pathway recombination
LROSL3_RS05900	COG0752	glycyl-tRNA synthetase alpha subunit
LROSL3_RS05905	COG0751	glycine-tRNA ligase activity
LROSL3_RS05915	COG0358	DNA primase activity
LROSL3_RS05920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LROSL3_RS05925	COG2384	SAM-dependent methyltransferase
LROSL3_RS05930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LROSL3_RS05945	COG0587	DNA-directed DNA polymerase activity
LROSL3_RS05955	COG2996	Protein conserved in bacteria
LROSL3_RS05970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LROSL3_RS05975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LROSL3_RS05980	COG1187	pseudouridine synthase activity
LROSL3_RS05985	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LROSL3_RS05995	COG0514	ATP-dependent DNA helicase (RecQ)
LROSL3_RS06005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LROSL3_RS06010	COG0539	negative regulation of cytoplasmic translation
LROSL3_RS06015	COG1160	GTP binding
LROSL3_RS06025	COG0457	Tetratricopeptide repeat
LROSL3_RS06035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LROSL3_RS06040	COG0617	tRNA 3'-terminal CCA addition
LROSL3_RS06045	COG0488	(ABC) transporter
LROSL3_RS06050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LROSL3_RS06055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LROSL3_RS06060	COG1272	protein, Hemolysin III
LROSL3_RS06065	COG1307	EDD domain protein, DegV family
LROSL3_RS06070	COG2755	lipolytic protein G-D-S-L family
LROSL3_RS06075	COG4698	Protein conserved in bacteria
LROSL3_RS06080	COG4479	Belongs to the UPF0346 family
LROSL3_RS06085	COG1396	sequence-specific DNA binding
LROSL3_RS06135	COG0583	DNA-binding transcription factor activity
LROSL3_RS06165	COG0738	Major facilitator superfamily
LROSL3_RS06175	COG1070	Carbohydrate kinase
LROSL3_RS06190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LROSL3_RS06195	COG0758	DNA mediated transformation
LROSL3_RS06200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LROSL3_RS06205	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LROSL3_RS06210	COG4974	Belongs to the 'phage' integrase family
LROSL3_RS06220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LROSL3_RS06225	COG0187	DNA topoisomerase II activity
LROSL3_RS06235	COG0583	DNA-binding transcription factor activity
LROSL3_RS06240	COG1227	inorganic diphosphatase activity
LROSL3_RS06255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LROSL3_RS06265	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LROSL3_RS06270	COG0351	phosphomethylpyrimidine kinase
LROSL3_RS06275	COG0352	thiamine-phosphate diphosphorylase activity
LROSL3_RS06290	COG4166	transmembrane transport
LROSL3_RS06295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LROSL3_RS06305	COG1131	(ABC) transporter
LROSL3_RS06315	COG4585	Histidine kinase
LROSL3_RS06320	COG2197	response regulator
LROSL3_RS06325	COG1472	Belongs to the glycosyl hydrolase 3 family
LROSL3_RS06370	COG1132	(ABC) transporter
LROSL3_RS06375	COG0589	response to stress
LROSL3_RS06385	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS06395	COG0519	Catalyzes the synthesis of GMP from XMP
LROSL3_RS06400	COG0656	L-ascorbic acid biosynthetic process
LROSL3_RS06410	COG1307	EDD domain protein, DegV family
LROSL3_RS06420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LROSL3_RS06425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LROSL3_RS06430	COG0505	Belongs to the CarA family
LROSL3_RS06435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LROSL3_RS06440	COG0564	pseudouridine synthase activity
LROSL3_RS06445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LROSL3_RS06450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LROSL3_RS06470	COG0116	Belongs to the methyltransferase superfamily
LROSL3_RS06480	COG3599	regulation of cell shape
LROSL3_RS06485	COG4474	Belongs to the UPF0398 family
LROSL3_RS06490	COG3331	DNA recombination
LROSL3_RS06505	COG0017	Asparaginyl-tRNA synthetase
LROSL3_RS06515	COG1199	ATP-dependent helicase activity
LROSL3_RS06515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LROSL3_RS06535	COG1304	FMN binding
LROSL3_RS06540	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LROSL3_RS06540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LROSL3_RS06545	COG0561	phosphatase activity
LROSL3_RS06555	COG0697	spore germination
LROSL3_RS06560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LROSL3_RS06565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LROSL3_RS06575	COG0531	amino acid
LROSL3_RS06580	COG0335	large ribosomal subunit rRNA binding
LROSL3_RS06585	COG0336	Belongs to the RNA methyltransferase TrmD family
LROSL3_RS06595	COG1837	Belongs to the UPF0109 family
LROSL3_RS06600	COG0228	four-way junction DNA binding
LROSL3_RS06620	COG1278	Cold shock
LROSL3_RS06645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LROSL3_RS06650	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LROSL3_RS06665	COG0552	protein localization to endoplasmic reticulum
LROSL3_RS06670	COG1196	nuclear chromosome segregation
LROSL3_RS06675	COG0571	ribonuclease III activity
LROSL3_RS06680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LROSL3_RS06685	COG0416	fatty acid biosynthetic process
LROSL3_RS06690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LROSL3_RS06695	COG1461	Dihydroxyacetone kinase
LROSL3_RS06700	COG1302	Protein conserved in bacteria
LROSL3_RS06705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LROSL3_RS06710	COG1564	THIamine pyrophosphokinase
LROSL3_RS06715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LROSL3_RS06720	COG1162	GTPase activity
LROSL3_RS06725	COG2815	serine threonine protein kinase
LROSL3_RS06725	COG0515	serine threonine protein kinase
LROSL3_RS06730	COG0631	protein serine/threonine phosphatase activity
LROSL3_RS06735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LROSL3_RS06735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LROSL3_RS06740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LROSL3_RS06745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LROSL3_RS06750	COG1554	hydrolase, family 65, central catalytic
LROSL3_RS06755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LROSL3_RS06760	COG1881	PFAM PEBP family protein
LROSL3_RS06770	COG0561	phosphatase activity
LROSL3_RS06775	COG1758	RNA polymerase activity
LROSL3_RS06780	COG0194	GDP metabolic process
LROSL3_RS06790	COG0497	DNA recombination
LROSL3_RS06795	COG1438	arginine binding
LROSL3_RS06800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LROSL3_RS06810	COG1722	exodeoxyribonuclease VII activity
LROSL3_RS06815	COG1570	exodeoxyribonuclease VII activity
LROSL3_RS06820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LROSL3_RS06825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LROSL3_RS06830	COG1302	Protein conserved in bacteria
LROSL3_RS06835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LROSL3_RS06840	COG0006	proline dipeptidase activity
LROSL3_RS06845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LROSL3_RS06855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LROSL3_RS06895	COG0789	Transcriptional regulator
LROSL3_RS06900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LROSL3_RS06905	COG0584	glycerophosphoryl diester phosphodiesterase
LROSL3_RS06915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LROSL3_RS06925	COG0705	Rhomboid family
LROSL3_RS06925	COG0457	Tetratricopeptide repeat
LROSL3_RS06930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LROSL3_RS06935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LROSL3_RS06940	COG0768	penicillin binding
LROSL3_RS06950	COG4841	protein insertion into membrane
LROSL3_RS06960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LROSL3_RS06965	COG0572	uridine kinase
LROSL3_RS06970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LROSL3_RS06975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LROSL3_RS06975	COG0072	phenylalanine-tRNA ligase activity
LROSL3_RS06980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LROSL3_RS06985	COG1733	regulation of RNA biosynthetic process
LROSL3_RS06995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LROSL3_RS07000	COG1254	Belongs to the acylphosphatase family
LROSL3_RS07005	COG0706	membrane insertase activity
LROSL3_RS07010	COG5002	protein histidine kinase activity
LROSL3_RS07015	COG0745	RESPONSE REGULATOR receiver
LROSL3_RS07025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LROSL3_RS07030	COG1399	metal-binding, possibly nucleic acid-binding protein
LROSL3_RS07035	COG1323	Belongs to the UPF0348 family
LROSL3_RS07040	COG2226	methyltransferase
LROSL3_RS07045	COG0799	negative regulation of ribosome biogenesis
LROSL3_RS07050	COG1713	HD superfamily hydrolase involved in NAD metabolism
LROSL3_RS07055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LROSL3_RS07065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LROSL3_RS07075	COG0564	pseudouridine synthase activity
LROSL3_RS07095	COG0463	Glycosyl transferase, family 2
LROSL3_RS07130	COG0516	GMP reductase activity
LROSL3_RS07130	COG0517	IMP dehydrogenase activity
LROSL3_RS07140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LROSL3_RS07145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LROSL3_RS07160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LROSL3_RS07165	COG2252	PERMEase
LROSL3_RS07170	COG1484	DNA-dependent DNA replication
LROSL3_RS07180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LROSL3_RS07185	COG0237	dephospho-CoA kinase activity
LROSL3_RS07190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LROSL3_RS07195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LROSL3_RS07195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LROSL3_RS07200	COG0670	Belongs to the BI1 family
LROSL3_RS07205	COG2814	Major facilitator Superfamily
LROSL3_RS07210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LROSL3_RS07215	COG1674	ftsk spoiiie
LROSL3_RS07240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LROSL3_RS07250	COG1131	(ABC) transporter
LROSL3_RS07255	COG0537	adenosine 5'-monophosphoramidase activity
LROSL3_RS07265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LROSL3_RS07270	COG3481	metal-dependent phosphohydrolase, HD sub domain
LROSL3_RS07275	COG4717	serine-type aminopeptidase activity
LROSL3_RS07280	COG0420	3'-5' exonuclease activity
LROSL3_RS07290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LROSL3_RS07295	COG1438	arginine binding
LROSL3_RS07300	COG0018	arginyl-trna synthetase
LROSL3_RS07330	COG1012	belongs to the aldehyde dehydrogenase family
LROSL3_RS07335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LROSL3_RS07350	COG1113	amino acid transport
LROSL3_RS07365	COG1464	Belongs to the NlpA lipoprotein family
LROSL3_RS07370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LROSL3_RS07375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LROSL3_RS07390	COG0534	Mate efflux family protein
LROSL3_RS07405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LROSL3_RS07410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LROSL3_RS07420	COG0302	gtp cyclohydrolase
LROSL3_RS07425	COG0302	gtp cyclohydrolase
LROSL3_RS07425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LROSL3_RS07445	COG1983	PspC domain protein
LROSL3_RS07475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LROSL3_RS07495	COG0561	phosphatase activity
LROSL3_RS07500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LROSL3_RS07505	COG1970	mechanosensitive ion channel activity
LROSL3_RS07510	COG1428	Deoxynucleoside kinase
LROSL3_RS07515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LROSL3_RS07520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LROSL3_RS07525	COG1187	pseudouridine synthase activity
LROSL3_RS07530	COG2244	polysaccharide biosynthetic process
LROSL3_RS07535	COG0495	leucyl-tRNA aminoacylation
LROSL3_RS07540	COG0671	phosphoesterase, PA-phosphatase related
LROSL3_RS07550	COG0477	Major facilitator Superfamily
LROSL3_RS07555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LROSL3_RS07565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LROSL3_RS07570	COG0519	Catalyzes the synthesis of GMP from XMP
LROSL3_RS07625	COG1609	Transcriptional regulator
LROSL3_RS07630	COG0006	proline dipeptidase activity
LROSL3_RS07655	COG0667	Aldo Keto reductase
LROSL3_RS07665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LROSL3_RS07675	COG1719	4-vinyl reductase, 4VR
LROSL3_RS07680	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LROSL3_RS07685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LROSL3_RS07690	COG1696	Membrane protein involved in D-alanine export
LROSL3_RS07695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LROSL3_RS07705	COG3118	belongs to the thioredoxin family
LROSL3_RS07710	COG1193	negative regulation of DNA recombination
LROSL3_RS07720	COG3906	Belongs to the UPF0473 family
LROSL3_RS07725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LROSL3_RS07730	COG4472	Bacterial protein of unknown function (DUF965)
LROSL3_RS07735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LROSL3_RS07740	COG0513	Belongs to the DEAD box helicase family
LROSL3_RS07745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LROSL3_RS07750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LROSL3_RS07755	COG1862	Preprotein translocase
LROSL3_RS07760	COG2255	four-way junction helicase activity
LROSL3_RS07765	COG0632	four-way junction helicase activity
LROSL3_RS07770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LROSL3_RS07775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LROSL3_RS07780	COG1418	mRNA catabolic process
LROSL3_RS07790	COG1131	(ABC) transporter
LROSL3_RS07805	COG1136	(ABC) transporter
LROSL3_RS07810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LROSL3_RS07815	COG1058	Belongs to the CinA family
LROSL3_RS07815	COG1546	Belongs to the CinA family
LROSL3_RS07820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LROSL3_RS07825	COG1426	Protein conserved in bacteria
LROSL3_RS07830	COG0612	Peptidase, M16
LROSL3_RS07835	COG0612	Peptidase, M16
LROSL3_RS07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LROSL3_RS07845	COG1126	abc transporter atp-binding protein
LROSL3_RS07850	COG0765	amino acid transport
LROSL3_RS07865	COG1077	Cell shape determining protein MreB Mrl
LROSL3_RS07870	COG2003	Belongs to the UPF0758 family
LROSL3_RS07875	COG0285	dihydrofolate synthase activity
LROSL3_RS07880	COG0525	valine-tRNA ligase activity
LROSL3_RS07885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LROSL3_RS07905	COG0301	tRNA thio-modification
LROSL3_RS07910	COG1104	cysteine desulfurase activity
LROSL3_RS07915	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LROSL3_RS07920	COG1956	GAF domain-containing protein
LROSL3_RS07925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LROSL3_RS07935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LROSL3_RS07965	COG1181	Belongs to the D-alanine--D-alanine ligase family
LROSL3_RS07975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LROSL3_RS07980	COG0509	glycine decarboxylation via glycine cleavage system
LROSL3_RS07985	COG0772	Belongs to the SEDS family
LROSL3_RS07995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LROSL3_RS08000	COG1077	Cell shape determining protein MreB Mrl
LROSL3_RS08020	COG3942	CHAP domain
LROSL3_RS08020	COG1388	LysM domain
LROSL3_RS08205	COG0270	DNA (cytosine-5-)-methyltransferase activity
LROSL3_RS08325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LROSL3_RS08335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LROSL3_RS08340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LROSL3_RS08345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LROSL3_RS08350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LROSL3_RS08355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LROSL3_RS08360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LROSL3_RS08365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LROSL3_RS08370	COG0356	it plays a direct role in the translocation of protons across the membrane
LROSL3_RS08375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LROSL3_RS08380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LROSL3_RS08385	COG0009	L-threonylcarbamoyladenylate synthase
LROSL3_RS08390	COG2890	protein-(glutamine-N5) methyltransferase activity
LROSL3_RS08395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LROSL3_RS08400	COG1435	thymidine kinase activity
LROSL3_RS08405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LROSL3_RS08410	COG3442	glutamine amidotransferase
LROSL3_RS08420	COG1113	amino acid transport
LROSL3_RS08430	COG1482	cell wall glycoprotein biosynthetic process
LROSL3_RS08435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LROSL3_RS08440	COG1174	glycine betaine transport
LROSL3_RS08445	COG1732	Glycine betaine
LROSL3_RS08465	COG1609	Transcriptional regulator
LROSL3_RS08470	COG1063	alcohol dehydrogenase
LROSL3_RS08475	COG1940	carbohydrate kinase activity
LROSL3_RS08485	COG0346	lactoylglutathione lyase activity
LROSL3_RS08490	COG1968	undecaprenyl-diphosphatase activity
LROSL3_RS08530	COG0025	NhaP-type Na H and K H
LROSL3_RS08555	COG4975	Glucose uptake
LROSL3_RS08560	COG1940	carbohydrate kinase activity
LROSL3_RS08595	COG1250	3-hydroxyacyl-CoA dehydrogenase
LROSL3_RS08610	COG0363	glucosamine-6-phosphate deaminase activity
LROSL3_RS08615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LROSL3_RS08620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LROSL3_RS08635	COG0025	NhaP-type Na H and K H
LROSL3_RS08640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LROSL3_RS08645	COG0708	Exodeoxyribonuclease III
LROSL3_RS08650	COG2176	DNA-directed DNA polymerase activity
LROSL3_RS08660	COG0802	atpase or kinase
LROSL3_RS08665	COG0280	phosphate acetyltransferase
LROSL3_RS08670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LROSL3_RS08685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LROSL3_RS08690	COG0557	exoribonuclease II activity
LROSL3_RS08700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LROSL3_RS08710	COG1309	transcriptional regulator
LROSL3_RS08715	COG0148	phosphopyruvate hydratase activity
LROSL3_RS08720	COG0149	triose-phosphate isomerase activity
LROSL3_RS08735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LROSL3_RS08745	COG1609	Transcriptional regulator
LROSL3_RS08750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LROSL3_RS08755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LROSL3_RS08760	COG2190	(PTS) system
LROSL3_RS08760	COG2211	Major facilitator Superfamily
LROSL3_RS08770	COG2017	converts alpha-aldose to the beta-anomer
LROSL3_RS08775	COG0602	queuosine metabolic process
LROSL3_RS08875	COG0735	belongs to the Fur family
LROSL3_RS08880	COG2814	Major facilitator Superfamily
LROSL3_RS08905	COG2508	Transcriptional regulator
LROSL3_RS08910	COG0778	Nitroreductase
LROSL3_RS08940	COG0740	serine-type endopeptidase activity
LROSL3_RS08945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LROSL3_RS08950	COG1309	transcriptional regulator
LROSL3_RS08960	COG1481	regulation of sporulation
LROSL3_RS08965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LROSL3_RS08970	COG1660	Displays ATPase and GTPase activities
LROSL3_RS08985	COG0531	amino acid
LROSL3_RS08990	COG0531	amino acid
LROSL3_RS08995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LROSL3_RS09000	COG0556	nucleotide-excision repair
LROSL3_RS09005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LROSL3_RS09010	COG0492	ferredoxin-NADP+ reductase activity
LROSL3_RS09015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LROSL3_RS09020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LROSL3_RS09025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LROSL3_RS09030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LROSL3_RS09035	COG1950	PFAM Membrane protein of
LROSL3_RS09045	COG0704	Plays a role in the regulation of phosphate uptake
LROSL3_RS09050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LROSL3_RS09055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LROSL3_RS09060	COG0581	inorganic phosphate transmembrane transporter activity
LROSL3_RS09065	COG0573	inorganic phosphate transmembrane transporter activity
LROSL3_RS09075	COG5002	protein histidine kinase activity
LROSL3_RS09080	COG0745	RESPONSE REGULATOR receiver
LROSL3_RS09090	COG0653	protein targeting
LROSL3_RS09100	COG1040	competence protein
LROSL3_RS09105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LROSL3_RS09110	COG1739	Uncharacterized protein family UPF0029
LROSL3_RS09115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LROSL3_RS09120	COG0531	amino acid
LROSL3_RS09135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LROSL3_RS09140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LROSL3_RS09145	COG0488	(ABC) transporter
LROSL3_RS09150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LROSL3_RS09155	COG0456	acetyltransferase
LROSL3_RS09165	COG1214	PFAM Peptidase M22, glycoprotease
LROSL3_RS09170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LROSL3_RS09185	COG4467	Involved in initiation control of chromosome replication
LROSL3_RS09190	COG0470	DNA polymerase III
LROSL3_RS09195	COG3870	Protein conserved in bacteria
LROSL3_RS09200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LROSL3_RS09205	COG1705	Flagellar rod assembly protein muramidase FlgJ
LROSL3_RS09215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LROSL3_RS09220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LROSL3_RS09225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LROSL3_RS09240	COG2813	Specifically methylates the guanine in position
LROSL3_RS09245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LROSL3_RS09250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LROSL3_RS09255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LROSL3_RS09260	COG1611	Belongs to the LOG family
LROSL3_RS09265	COG0392	lysyltransferase activity
LROSL3_RS09265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LROSL3_RS09275	COG0222	ribosome binding
LROSL3_RS09285	COG0081	regulation of translation
LROSL3_RS09315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LROSL3_RS09320	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LROSL3_RS09325	COG0215	cysteine-tRNA ligase activity
LROSL3_RS09340	COG4956	integral membrane protein (PIN domain superfamily)
LROSL3_RS09360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LROSL3_RS09395	COG1278	Cold shock
LROSL3_RS09405	COG1230	cation diffusion facilitator family transporter
LROSL3_RS09415	COG3250	beta-galactosidase activity
LROSL3_RS09425	COG2814	Major facilitator Superfamily
LROSL3_RS09455	COG1072	(Pantothenic acid kinase))
LROSL3_RS09460	COG3973	AAA domain
LROSL3_RS09465	COG0586	Pfam SNARE associated Golgi protein
LROSL3_RS09475	COG1164	Oligoendopeptidase f
LROSL3_RS09480	COG1164	Oligoendopeptidase f
LROSL3_RS09505	COG4608	Belongs to the ABC transporter superfamily
LROSL3_RS09510	COG0444	Belongs to the ABC transporter superfamily
LROSL3_RS09515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LROSL3_RS09520	COG0601	transmembrane transport
LROSL3_RS09525	COG4166	transmembrane transport
LROSL3_RS09540	COG4166	transmembrane transport
LROSL3_RS09545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LROSL3_RS09555	COG1396	sequence-specific DNA binding
LROSL3_RS09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LROSL3_RS09625	COG0601	transmembrane transport
LROSL3_RS09630	COG4608	Belongs to the ABC transporter superfamily
LROSL3_RS09645	COG1131	(ABC) transporter
LROSL3_RS09650	COG0765	amino acid transport
LROSL3_RS09655	COG0765	amino acid transport
LROSL3_RS09660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LROSL3_RS09680	COG0735	belongs to the Fur family
LROSL3_RS09685	COG0194	GDP metabolic process
LROSL3_RS09690	COG0531	amino acid
LROSL3_RS09715	COG1177	transmembrane transport
LROSL3_RS09730	COG4166	transmembrane transport
LROSL3_RS09735	COG2936	dipeptidyl-peptidase activity
LROSL3_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
LROSL3_RS09790	COG2267	carboxylic ester hydrolase activity
LROSL3_RS09805	COG1114	Component of the transport system for branched-chain amino acids
LROSL3_RS09820	COG0604	alcohol dehydrogenase
LROSL3_RS09825	COG1733	regulation of RNA biosynthetic process
LROSL3_RS09845	COG0514	ATP-dependent DNA helicase (RecQ)
LROSL3_RS09865	COG3590	peptidase
LROSL3_RS09870	COG0702	epimerase
LROSL3_RS09885	COG2211	Major facilitator Superfamily
LROSL3_RS09895	COG1051	belongs to the nudix hydrolase family
LROSL3_RS09900	COG1309	transcriptional regulator
LROSL3_RS09905	COG0300	oxidoreductase activity
LROSL3_RS09935	COG1846	Transcriptional regulator
LROSL3_RS09945	COG0625	glutathione transferase activity
LROSL3_RS09950	COG0640	Transcriptional regulator
LROSL3_RS09970	COG0488	(ABC) transporter
LROSL3_RS10000	COG1307	EDD domain protein, DegV family
LROSL3_RS10005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LROSL3_RS10010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LROSL3_RS10030	COG4120	Belongs to the binding-protein-dependent transport system permease family
LROSL3_RS10040	COG4166	transmembrane transport
LROSL3_RS10045	COG1216	Glycosyl transferase, family 2
LROSL3_RS10070	COG2084	Dehydrogenase
LROSL3_RS10075	COG0537	adenosine 5'-monophosphoramidase activity
LROSL3_RS10090	COG0789	Transcriptional regulator
LROSL3_RS10095	COG1393	Belongs to the ArsC family
LROSL3_RS10105	COG4221	oxidoreductase activity
LROSL3_RS10110	COG1733	regulation of RNA biosynthetic process
LROSL3_RS10120	COG3118	belongs to the thioredoxin family
LROSL3_RS10125	COG1304	FMN binding
LROSL3_RS10130	COG0861	Integral membrane protein TerC family
LROSL3_RS10135	COG0564	pseudouridine synthase activity
LROSL3_RS10140	COG0028	Belongs to the TPP enzyme family
LROSL3_RS10150	COG1846	Transcriptional regulator
LROSL3_RS10175	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LROSL3_RS10180	COG3548	integral membrane protein
LROSL3_RS10185	COG0789	Transcriptional regulator
LROSL3_RS10195	COG0588	phosphoglycerate mutase activity
LROSL3_RS10200	COG1368	sulfuric ester hydrolase activity
LROSL3_RS10215	COG0681	Belongs to the peptidase S26 family
LROSL3_RS10220	COG0492	ferredoxin-NADP+ reductase activity
LROSL3_RS10270	COG2814	Major facilitator Superfamily
LROSL3_RS10280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LROSL3_RS10290	COG2217	Heavy metal translocating P-type atpase
LROSL3_RS10320	COG1957	nucleoside hydrolase
LROSL3_RS10330	COG4684	Psort location CytoplasmicMembrane, score
LROSL3_RS10340	COG1122	ATPase activity
LROSL3_RS10380	COG1846	Transcriptional regulator
LROSL3_RS10390	COG0346	lactoylglutathione lyase activity
LROSL3_RS10395	COG0586	Pfam SNARE associated Golgi protein
LROSL3_RS10415	COG0095	Lipoate-protein ligase
LROSL3_RS10420	COG0589	response to stress
LROSL3_RS10425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LROSL3_RS10430	COG0463	Glycosyl transferase, family 2
LROSL3_RS10435	COG1307	EDD domain protein, DegV family
LROSL3_RS10680	COG0629	single-stranded DNA binding
LROSL3_RS10725	COG1396	sequence-specific DNA binding
LROSL3_RS10740	COG4974	Belongs to the 'phage' integrase family
LROSL3_RS10745	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LROSL3_RS10750	COG2188	Transcriptional regulator
LROSL3_RS10755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LROSL3_RS10765	COG1418	mRNA catabolic process
LROSL3_RS10770	COG3279	Response regulator of the LytR AlgR family
LROSL3_RS10775	COG1131	(ABC) transporter
LROSL3_RS10795	COG2814	Major facilitator Superfamily
LROSL3_RS10810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LROSL3_RS10810	COG0248	Ppx GppA phosphatase
LROSL3_RS10815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LROSL3_RS10825	COG2326	polyphosphate kinase activity
LROSL3_RS10830	COG0561	phosphatase activity
LROSL3_RS10860	COG1454	alcohol dehydrogenase
LROSL3_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
LROSL3_RS10885	COG2137	regulation of response to DNA damage stimulus
LROSL3_RS10900	COG0071	Belongs to the small heat shock protein (HSP20) family
LROSL3_RS10910	COG1253	flavin adenine dinucleotide binding
LROSL3_RS10930	COG2814	Major facilitator Superfamily
LROSL3_RS10935	COG1064	alcohol dehydrogenase
LROSL3_RS10950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LROSL3_RS10955	COG2252	PERMEase
LROSL3_RS10960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LROSL3_RS11035	COG1131	(ABC) transporter
LROSL3_RS11060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LROSL3_RS11065	COG2183	response to ionizing radiation
LROSL3_RS11070	COG2814	Major facilitator Superfamily
LROSL3_RS11085	COG1131	(ABC) transporter
LROSL3_RS11105	COG1193	negative regulation of DNA recombination
LROSL3_RS11125	COG0446	pyridine nucleotide-disulphide oxidoreductase
LROSL3_RS11135	COG2409	Drug exporters of the RND superfamily
LROSL3_RS11135	COG1033	growth of symbiont in host cell
LROSL3_RS11140	COG1959	2 iron, 2 sulfur cluster binding
LROSL3_RS11210	COG0183	Belongs to the thiolase family
LROSL3_RS11215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LROSL3_RS11270	COG0471	metal ion transport
LROSL3_RS11275	COG0583	DNA-binding transcription factor activity
LROSL3_RS11285	COG1307	EDD domain protein, DegV family
LROSL3_RS11300	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LROSL3_RS11330	COG0640	Transcriptional regulator
LROSL3_RS11335	COG2814	Major facilitator Superfamily
LROSL3_RS11340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LROSL3_RS11345	COG0436	Aminotransferase
LROSL3_RS11350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LROSL3_RS11355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LROSL3_RS11360	COG1473	amidohydrolase
LROSL3_RS11365	COG2171	N-acyltransferase activity
LROSL3_RS11370	COG0019	diaminopimelate decarboxylase activity
LROSL3_RS11375	COG0527	aspartate kinase activity
LROSL3_RS11380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LROSL3_RS11385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LROSL3_RS11395	COG1132	(ABC) transporter
LROSL3_RS11400	COG1132	(ABC) transporter
LROSL3_RS11455	COG1174	glycine betaine transport
LROSL3_RS11460	COG1125	glycine betaine transport
LROSL3_RS11460	COG0517	IMP dehydrogenase activity
LROSL3_RS11480	COG3842	ATPase activity
LROSL3_RS11485	COG1175	transmembrane transport
LROSL3_RS11490	COG0395	ABC-type sugar transport system, permease component
LROSL3_RS11505	COG0737	Belongs to the 5'-nucleotidase family
LROSL3_RS11510	COG1252	NADH dehydrogenase
LROSL3_RS11540	COG0681	Belongs to the peptidase S26 family
LROSL3_RS11580	COG3706	GGDEF domain
LROSL3_RS11595	COG1215	transferase activity, transferring glycosyl groups
LROSL3_RS11630	COG1132	(ABC) transporter
LROSL3_RS11640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LROSL3_RS11655	COG0516	GMP reductase activity
LROSL3_RS11665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LROSL3_RS11755	COG0640	Transcriptional regulator
LROSL3_RS11760	COG1131	(ABC) transporter
LROSL3_RS11765	COG0842	Transport permease protein
LROSL3_RS11775	COG2226	methyltransferase
LROSL3_RS11780	COG0531	amino acid
LROSL3_RS11865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LROSL3_RS11870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LROSL3_RS11880	COG4221	oxidoreductase activity
LROSL3_RS11885	COG1733	regulation of RNA biosynthetic process
LROSL3_RS11890	COG4975	Glucose uptake
LROSL3_RS11900	COG1902	pentaerythritol trinitrate reductase activity
LROSL3_RS11910	COG1733	regulation of RNA biosynthetic process
LROSL3_RS11940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LROSL3_RS11955	COG5002	protein histidine kinase activity
LROSL3_RS11960	COG0745	RESPONSE REGULATOR receiver
LROSL3_RS12000	COG0110	maltose O-acetyltransferase activity
LROSL3_RS12005	COG1609	Transcriptional regulator
LROSL3_RS12050	COG2197	response regulator
LROSL3_RS12070	COG0719	Fe-S assembly protein
LROSL3_RS12080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LROSL3_RS12085	COG0719	Fe-S assembly protein
LROSL3_RS12090	COG0396	ATPase activity
LROSL3_RS12110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LROSL3_RS12110	COG0167	dihydroorotate dehydrogenase activity
LROSL3_RS12115	COG0493	'glutamate synthase
LROSL3_RS12120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LROSL3_RS12130	COG3842	ATPase activity
LROSL3_RS12140	COG1176	ABC-type spermidine putrescine transport system, permease component I
LROSL3_RS12145	COG0436	Aminotransferase
LROSL3_RS12150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LROSL3_RS12170	COG4886	Leucine-rich repeat (LRR) protein
LROSL3_RS12170	COG4932	domain protein
LROSL3_RS12175	COG2814	Major facilitator Superfamily
LROSL3_RS12180	COG0284	orotidine-5'-phosphate decarboxylase activity
LROSL3_RS12185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LROSL3_RS12190	COG0167	dihydroorotate dehydrogenase activity
LROSL3_RS12200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LROSL3_RS12210	COG1442	glycosyl transferase family 8
LROSL3_RS12215	COG1442	glycosyl transferase family 8
LROSL3_RS12225	COG0445	tRNA wobble uridine modification
LROSL3_RS12230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LROSL3_RS12240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LROSL3_RS12255	COG0706	membrane insertase activity
LROSL3_RS12260	COG0594	ribonuclease P activity
LROSL3_RS12265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LROSL3_RS12280	COG2261	transglycosylase associated protein
LROSL3_RS12295	COG1192	Involved in chromosome partitioning
LROSL3_RS12300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LROSL3_RS12355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LROSL3_RS12370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LROSL3_RS12395	COG2261	transglycosylase associated protein
LROSL3_RS12425	COG0783	Belongs to the Dps family