locus-tag	class	description
GTO85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTO85_RS00010	COG0592	DNA-directed DNA polymerase activity
GTO85_RS00015	COG2501	S4 domain
GTO85_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTO85_RS00025	COG0187	DNA topoisomerase II activity
GTO85_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTO85_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
GTO85_RS00040	COG0629	single-stranded DNA binding
GTO85_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTO85_RS00080	COG0359	binds to the 23S rRNA
GTO85_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
GTO85_RS00095	COG1307	EDD domain protein, DegV family
GTO85_RS00100	COG1132	(ABC) transporter
GTO85_RS00105	COG1940	carbohydrate kinase activity
GTO85_RS00115	COG2261	transglycosylase associated protein
GTO85_RS00125	COG1285	pathogenesis
GTO85_RS00225	COG1396	sequence-specific DNA binding
GTO85_RS00225	COG3800	Transcriptional regulator
GTO85_RS00240	COG0531	amino acid
GTO85_RS00270	COG0628	permease
GTO85_RS00290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTO85_RS00305	COG1011	Hydrolase
GTO85_RS00340	COG0561	phosphatase activity
GTO85_RS00365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTO85_RS00380	COG0708	Exodeoxyribonuclease III
GTO85_RS00470	COG1442	glycosyl transferase family 8
GTO85_RS00480	COG1442	glycosyl transferase family 8
GTO85_RS00505	COG0745	RESPONSE REGULATOR receiver
GTO85_RS00510	COG5002	protein histidine kinase activity
GTO85_RS00525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GTO85_RS00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTO85_RS00535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTO85_RS00560	COG2267	carboxylic ester hydrolase activity
GTO85_RS00570	COG1122	ATPase activity
GTO85_RS00580	COG0501	Belongs to the peptidase M48B family
GTO85_RS00585	COG1704	LemA family
GTO85_RS00590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTO85_RS00615	COG1215	transferase activity, transferring glycosyl groups
GTO85_RS00645	COG1126	abc transporter atp-binding protein
GTO85_RS00650	COG0765	amino acid transport
GTO85_RS00655	COG2094	Belongs to the DNA glycosylase MPG family
GTO85_RS00660	COG3189	MarR family transcriptional regulator
GTO85_RS00665	COG0861	Integral membrane protein TerC family
GTO85_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTO85_RS00705	COG0328	RNA-DNA hybrid ribonuclease activity
GTO85_RS00715	COG1216	Glycosyl transferase, family 2
GTO85_RS00745	COG0765	amino acid transport
GTO85_RS00750	COG1126	abc transporter atp-binding protein
GTO85_RS00760	COG1181	Belongs to the D-alanine--D-alanine ligase family
GTO85_RS00825	COG2365	Tyrosine phosphatase family
GTO85_RS00830	COG0589	response to stress
GTO85_RS00845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GTO85_RS00855	COG3639	organic phosphonate transmembrane transporter activity
GTO85_RS00860	COG0519	Catalyzes the synthesis of GMP from XMP
GTO85_RS00875	COG0367	asparagine synthase
GTO85_RS00890	COG0602	queuosine metabolic process
GTO85_RS00895	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO85_RS00905	COG2814	Major facilitator Superfamily
GTO85_RS00910	COG3590	peptidase
GTO85_RS00920	COG3158	transport of potassium into the cell
GTO85_RS00980	COG1388	LysM domain
GTO85_RS00980	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO85_RS00990	COG0569	domain protein
GTO85_RS00990	COG0475	glutathione-regulated potassium exporter activity
GTO85_RS01015	COG0588	phosphoglycerate mutase activity
GTO85_RS01030	COG1316	TRANSCRIPTIONal
GTO85_RS01035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTO85_RS01040	COG1368	sulfuric ester hydrolase activity
GTO85_RS01050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTO85_RS01065	COG3579	cysteine-type endopeptidase activity
GTO85_RS01070	COG1418	mRNA catabolic process
GTO85_RS01075	COG4166	transmembrane transport
GTO85_RS01085	COG0517	IMP dehydrogenase activity
GTO85_RS01085	COG0516	GMP reductase activity
GTO85_RS01090	COG0601	transmembrane transport
GTO85_RS01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTO85_RS01100	COG0444	Belongs to the ABC transporter superfamily
GTO85_RS01105	COG4608	Belongs to the ABC transporter superfamily
GTO85_RS01110	COG3579	cysteine-type endopeptidase activity
GTO85_RS01120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTO85_RS01145	COG2131	deaminase
GTO85_RS01155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTO85_RS01160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO85_RS01160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO85_RS01165	COG0084	hydrolase, TatD family'
GTO85_RS01175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTO85_RS01180	COG4466	Protein conserved in bacteria
GTO85_RS01185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO85_RS01190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTO85_RS01205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTO85_RS01220	COG1078	dGTPase activity
GTO85_RS01230	COG3343	RNA polymerase activity
GTO85_RS01235	COG0504	CTP synthase activity
GTO85_RS01240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTO85_RS01250	COG4690	dipeptidase activity
GTO85_RS01260	COG2233	PERMEase
GTO85_RS01265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO85_RS01275	COG1395	domain, Protein
GTO85_RS01280	COG0519	Catalyzes the synthesis of GMP from XMP
GTO85_RS01285	COG1733	regulation of RNA biosynthetic process
GTO85_RS01310	COG1575	Belongs to the MenA family. Type 1 subfamily
GTO85_RS01325	COG1304	FMN binding
GTO85_RS01340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTO85_RS01355	COG0531	amino acid
GTO85_RS01360	COG0561	phosphatase activity
GTO85_RS01365	COG0366	Alpha amylase catalytic
GTO85_RS01370	COG0254	rRNA binding
GTO85_RS01375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTO85_RS01385	COG0736	holo-[acyl-carrier-protein] synthase activity
GTO85_RS01390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTO85_RS01400	COG0039	L-malate dehydrogenase activity
GTO85_RS01405	COG0193	aminoacyl-tRNA hydrolase activity
GTO85_RS01410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTO85_RS01415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTO85_RS01425	COG1185	polyribonucleotide nucleotidyltransferase activity
GTO85_RS01430	COG0037	tRNA processing
GTO85_RS01440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTO85_RS01450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTO85_RS01465	COG0737	Belongs to the 5'-nucleotidase family
GTO85_RS01490	COG1956	GAF domain-containing protein
GTO85_RS01495	COG0542	response to heat
GTO85_RS01500	COG0085	RNA polymerase activity
GTO85_RS01505	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTO85_RS01510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTO85_RS01515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GTO85_RS01520	COG0049	tRNA binding
GTO85_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTO85_RS01530	COG0051	transcription antitermination factor activity, RNA binding
GTO85_RS01535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTO85_RS01540	COG0088	Forms part of the polypeptide exit tunnel
GTO85_RS01545	COG0089	rRNA binding
GTO85_RS01550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTO85_RS01560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTO85_RS01565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTO85_RS01570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTO85_RS01575	COG0255	Belongs to the universal ribosomal protein uL29 family
GTO85_RS01580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTO85_RS01585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTO85_RS01590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GTO85_RS01595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTO85_RS01605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTO85_RS01610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GTO85_RS01615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTO85_RS01620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTO85_RS01625	COG1841	ribosomal large subunit assembly
GTO85_RS01630	COG0200	Binds to the 23S rRNA
GTO85_RS01640	COG0563	adenylate kinase activity
GTO85_RS01645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTO85_RS01655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTO85_RS01660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTO85_RS01665	COG0202	RNA polymerase activity
GTO85_RS01670	COG0203	ribosomal protein L17
GTO85_RS01675	COG1122	ATPase activity
GTO85_RS01680	COG1122	ATPase activity
GTO85_RS01685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTO85_RS01690	COG0101	tRNA pseudouridine synthase activity
GTO85_RS01695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTO85_RS01700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTO85_RS01735	COG1230	cation diffusion facilitator family transporter
GTO85_RS01745	COG0588	phosphoglycerate mutase activity
GTO85_RS01770	COG0756	dUTP diphosphatase activity
GTO85_RS01780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTO85_RS01785	COG0215	cysteine-tRNA ligase activity
GTO85_RS01790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GTO85_RS01795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTO85_RS01815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTO85_RS01820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTO85_RS01830	COG0250	Participates in transcription elongation, termination and antitermination
GTO85_RS01835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTO85_RS01840	COG0081	regulation of translation
GTO85_RS01850	COG0573	inorganic phosphate transmembrane transporter activity
GTO85_RS01855	COG0581	inorganic phosphate transmembrane transporter activity
GTO85_RS01860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTO85_RS01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTO85_RS01870	COG0704	Plays a role in the regulation of phosphate uptake
GTO85_RS01875	COG0679	Auxin Efflux Carrier
GTO85_RS01880	COG0201	protein transport
GTO85_RS01890	COG1073	alpha beta
GTO85_RS01900	COG0653	protein targeting
GTO85_RS01940	COG4372	Transposase
GTO85_RS01950	COG1442	glycosyl transferase family 8
GTO85_RS01960	COG1442	glycosyl transferase family 8
GTO85_RS01970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTO85_RS01975	COG0222	ribosome binding
GTO85_RS01985	COG2813	Specifically methylates the guanine in position
GTO85_RS01995	COG0590	tRNA wobble adenosine to inosine editing
GTO85_RS02005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GTO85_RS02015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTO85_RS02020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTO85_RS02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTO85_RS02035	COG3870	Protein conserved in bacteria
GTO85_RS02060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GTO85_RS02065	COG1214	PFAM Peptidase M22, glycoprotease
GTO85_RS02075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTO85_RS02090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GTO85_RS02100	COG0488	(ABC) transporter
GTO85_RS02105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GTO85_RS02120	COG1263	PTS System
GTO85_RS02120	COG2190	(PTS) system
GTO85_RS02120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTO85_RS02135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTO85_RS02140	COG0459	protein refolding
GTO85_RS02145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTO85_RS02150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTO85_RS02155	COG0632	four-way junction helicase activity
GTO85_RS02160	COG2255	four-way junction helicase activity
GTO85_RS02170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTO85_RS02175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTO85_RS02180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTO85_RS02185	COG0513	Belongs to the DEAD box helicase family
GTO85_RS02190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTO85_RS02195	COG4472	Bacterial protein of unknown function (DUF965)
GTO85_RS02200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTO85_RS02205	COG3906	Belongs to the UPF0473 family
GTO85_RS02210	COG1193	negative regulation of DNA recombination
GTO85_RS02215	COG3118	belongs to the thioredoxin family
GTO85_RS02225	COG1719	4-vinyl reductase, 4VR
GTO85_RS02230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTO85_RS02235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTO85_RS02250	COG0668	transmembrane transport
GTO85_RS02265	COG0006	proline dipeptidase activity
GTO85_RS02275	COG0584	glycerophosphoryl diester phosphodiesterase
GTO85_RS02285	COG0737	Belongs to the 5'-nucleotidase family
GTO85_RS02295	COG0647	UMP catabolic process
GTO85_RS02305	COG0586	Pfam SNARE associated Golgi protein
GTO85_RS02310	COG0492	ferredoxin-NADP+ reductase activity
GTO85_RS02475	COG0438	transferase activity, transferring glycosyl groups
GTO85_RS02480	COG0438	transferase activity, transferring glycosyl groups
GTO85_RS02490	COG1368	sulfuric ester hydrolase activity
GTO85_RS02495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTO85_RS02500	COG0557	exoribonuclease II activity
GTO85_RS02505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTO85_RS02535	COG4974	Belongs to the 'phage' integrase family
GTO85_RS02545	COG1396	sequence-specific DNA binding
GTO85_RS02620	COG3764	Sortase (surface protein transpeptidase)
GTO85_RS02815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTO85_RS02820	COG0477	Major facilitator Superfamily
GTO85_RS02825	COG1737	Transcriptional regulator
GTO85_RS02835	COG2382	esterase
GTO85_RS02840	COG1263	PTS System
GTO85_RS02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTO85_RS02850	COG1271	oxidase subunit
GTO85_RS02855	COG1294	oxidase, subunit
GTO85_RS02860	COG4988	ABC transporter
GTO85_RS02865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTO85_RS02870	COG2226	methyltransferase
GTO85_RS02875	COG0142	geranyltranstransferase activity
GTO85_RS02895	COG0583	DNA-binding transcription factor activity
GTO85_RS02900	COG0671	phosphoesterase, PA-phosphatase related
GTO85_RS02905	COG0495	leucyl-tRNA aminoacylation
GTO85_RS02910	COG2244	polysaccharide biosynthetic process
GTO85_RS02915	COG1983	PspC domain protein
GTO85_RS02925	COG1686	Belongs to the peptidase S11 family
GTO85_RS02930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTO85_RS02935	COG1376	ErfK ybiS ycfS ynhG family protein
GTO85_RS02940	COG0018	arginyl-trna synthetase
GTO85_RS02950	COG1051	belongs to the nudix hydrolase family
GTO85_RS02970	COG3279	Response regulator of the LytR AlgR family
GTO85_RS02980	COG0477	Major facilitator Superfamily
GTO85_RS02990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS03000	COG0583	DNA-binding transcription factor activity
GTO85_RS03015	COG3052	prosthetic group binding
GTO85_RS03030	COG2267	carboxylic ester hydrolase activity
GTO85_RS03035	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GTO85_RS03045	COG2723	6-phospho-beta-galactosidase activity
GTO85_RS03050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS03055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTO85_RS03060	COG0588	phosphoglycerate mutase activity
GTO85_RS03065	COG0574	Belongs to the PEP-utilizing enzyme family
GTO85_RS03065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GTO85_RS03070	COG0564	pseudouridine synthase activity
GTO85_RS03075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTO85_RS03080	COG3679	Belongs to the UPF0342 family
GTO85_RS03095	COG3481	metal-dependent phosphohydrolase, HD sub domain
GTO85_RS03115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTO85_RS03125	COG0537	adenosine 5'-monophosphoramidase activity
GTO85_RS03130	COG1131	(ABC) transporter
GTO85_RS03140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GTO85_RS03150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTO85_RS03155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTO85_RS03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTO85_RS03230	COG0151	Belongs to the GarS family
GTO85_RS03275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO85_RS03275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO85_RS03280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTO85_RS03285	COG0237	dephospho-CoA kinase activity
GTO85_RS03290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTO85_RS03300	COG1484	DNA-dependent DNA replication
GTO85_RS03305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTO85_RS03325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTO85_RS03345	COG0778	Nitroreductase
GTO85_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
GTO85_RS03355	COG0300	oxidoreductase activity
GTO85_RS03390	COG1131	(ABC) transporter
GTO85_RS03410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTO85_RS03420	COG3842	ATPase activity
GTO85_RS03425	COG0395	ABC-type sugar transport system, permease component
GTO85_RS03430	COG1176	ABC-type spermidine putrescine transport system, permease component I
GTO85_RS03440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GTO85_RS03445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTO85_RS03450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTO85_RS03455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GTO85_RS03465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GTO85_RS03470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTO85_RS03475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTO85_RS03480	COG1713	HD superfamily hydrolase involved in NAD metabolism
GTO85_RS03485	COG0799	negative regulation of ribosome biogenesis
GTO85_RS03490	COG1323	Belongs to the UPF0348 family
GTO85_RS03500	COG0745	RESPONSE REGULATOR receiver
GTO85_RS03505	COG5002	protein histidine kinase activity
GTO85_RS03530	COG0706	membrane insertase activity
GTO85_RS03535	COG1254	Belongs to the acylphosphatase family
GTO85_RS03540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTO85_RS03545	COG1733	regulation of RNA biosynthetic process
GTO85_RS03550	COG0765	amino acid transport
GTO85_RS03555	COG0765	amino acid transport
GTO85_RS03560	COG1126	abc transporter atp-binding protein
GTO85_RS03565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO85_RS03570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTO85_RS03575	COG0072	phenylalanine-tRNA ligase activity
GTO85_RS03580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTO85_RS03605	COG0561	phosphatase activity
GTO85_RS03610	COG4166	transmembrane transport
GTO85_RS03655	COG2204	response regulator
GTO85_RS03670	COG1454	alcohol dehydrogenase
GTO85_RS03680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTO85_RS03705	COG1053	succinate dehydrogenase
GTO85_RS03780	COG2971	BadF BadG BcrA BcrD
GTO85_RS03790	COG0768	penicillin binding
GTO85_RS03795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTO85_RS03800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTO85_RS03815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTO85_RS03820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTO85_RS03845	COG0477	Major facilitator Superfamily
GTO85_RS03870	COG4166	transmembrane transport
GTO85_RS03890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GTO85_RS03900	COG2376	Dihydroxyacetone kinase
GTO85_RS03905	COG1461	Dihydroxyacetone kinase
GTO85_RS03910	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GTO85_RS03915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTO85_RS03930	COG1053	succinate dehydrogenase
GTO85_RS03940	COG0471	metal ion transport
GTO85_RS03945	COG1053	succinate dehydrogenase
GTO85_RS03945	COG3976	FMN-binding domain protein
GTO85_RS03950	COG2801	Transposase and inactivated derivatives
GTO85_RS03975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO85_RS03975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTO85_RS04020	COG1609	Transcriptional regulator
GTO85_RS04035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTO85_RS04040	COG3250	beta-galactosidase activity
GTO85_RS04045	COG3250	beta-galactosidase activity
GTO85_RS04050	COG1609	Transcriptional regulator
GTO85_RS04055	COG2190	(PTS) system
GTO85_RS04055	COG2211	Major facilitator Superfamily
GTO85_RS04060	COG1874	Beta-galactosidase
GTO85_RS04065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTO85_RS04070	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GTO85_RS04075	COG2017	converts alpha-aldose to the beta-anomer
GTO85_RS04090	COG1653	transport
GTO85_RS04095	COG1175	transmembrane transport
GTO85_RS04100	COG0395	ABC-type sugar transport system, permease component
GTO85_RS04105	COG3842	ATPase activity
GTO85_RS04110	COG3345	alpha-galactosidase
GTO85_RS04115	COG0366	Alpha amylase catalytic
GTO85_RS04120	COG2357	RelA SpoT domain protein
GTO85_RS04125	COG0745	RESPONSE REGULATOR receiver
GTO85_RS04130	COG5002	protein histidine kinase activity
GTO85_RS04175	COG1304	FMN binding
GTO85_RS04180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTO85_RS04185	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO85_RS04190	COG1760	l-serine dehydratase
GTO85_RS04195	COG1760	l-serine dehydratase
GTO85_RS04225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTO85_RS04230	COG0284	orotidine-5'-phosphate decarboxylase activity
GTO85_RS04235	COG0167	dihydroorotate dehydrogenase activity
GTO85_RS04245	COG0540	Belongs to the ATCase OTCase family
GTO85_RS04250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GTO85_RS04255	COG0505	Belongs to the CarA family
GTO85_RS04260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTO85_RS04265	COG1620	l-lactate permease
GTO85_RS04270	COG4975	Glucose uptake
GTO85_RS04285	COG2936	dipeptidyl-peptidase activity
GTO85_RS04310	COG0561	phosphatase activity
GTO85_RS04315	COG1132	(ABC) transporter
GTO85_RS04320	COG1393	Belongs to the ArsC family
GTO85_RS04350	COG1942	4-Oxalocrotonate Tautomerase
GTO85_RS04375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTO85_RS04380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTO85_RS04385	COG0006	proline dipeptidase activity
GTO85_RS04390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTO85_RS04395	COG1302	Protein conserved in bacteria
GTO85_RS04405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTO85_RS04410	COG1570	exodeoxyribonuclease VII activity
GTO85_RS04415	COG1722	exodeoxyribonuclease VII activity
GTO85_RS04425	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GTO85_RS04430	COG0497	DNA recombination
GTO85_RS04440	COG0194	GDP metabolic process
GTO85_RS04445	COG1758	RNA polymerase activity
GTO85_RS04450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTO85_RS04455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTO85_RS04460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTO85_RS04460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTO85_RS04470	COG0515	serine threonine protein kinase
GTO85_RS04470	COG2815	serine threonine protein kinase
GTO85_RS04475	COG1162	GTPase activity
GTO85_RS04480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTO85_RS04495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTO85_RS04505	COG1461	Dihydroxyacetone kinase
GTO85_RS04510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTO85_RS04515	COG0416	fatty acid biosynthetic process
GTO85_RS04520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTO85_RS04530	COG4608	Belongs to the ABC transporter superfamily
GTO85_RS04535	COG0601	transmembrane transport
GTO85_RS04555	COG0571	ribonuclease III activity
GTO85_RS04560	COG1196	nuclear chromosome segregation
GTO85_RS04565	COG0552	protein localization to endoplasmic reticulum
GTO85_RS04580	COG1136	(ABC) transporter
GTO85_RS04590	COG0531	amino acid
GTO85_RS04595	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GTO85_RS04600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTO85_RS04605	COG0228	four-way junction DNA binding
GTO85_RS04610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTO85_RS04615	COG0336	Belongs to the RNA methyltransferase TrmD family
GTO85_RS04620	COG0335	large ribosomal subunit rRNA binding
GTO85_RS04640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTO85_RS04645	COG4224	UPF0291 protein
GTO85_RS04650	COG3763	UPF0154 protein
GTO85_RS04655	COG1132	(ABC) transporter
GTO85_RS04660	COG1132	(ABC) transporter
GTO85_RS04665	COG3590	peptidase
GTO85_RS04670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTO85_RS04675	COG0204	Acyl-transferase
GTO85_RS04680	COG2827	Endonuclease containing a URI domain
GTO85_RS04685	COG0052	Belongs to the universal ribosomal protein uS2 family
GTO85_RS04690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTO85_RS04695	COG0528	UMP kinase activity
GTO85_RS04700	COG0233	cytoplasmic translational termination
GTO85_RS04705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTO85_RS04710	COG4589	Belongs to the CDS family
GTO85_RS04715	COG0750	zinc metalloprotease
GTO85_RS04720	COG0442	prolyl-tRNA aminoacylation
GTO85_RS04730	COG0779	Required for maturation of 30S ribosomal subunits
GTO85_RS04735	COG0195	Participates in both transcription termination and antitermination
GTO85_RS04740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GTO85_RS04750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTO85_RS04755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTO85_RS04760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GTO85_RS04765	COG0196	riboflavin kinase activity
GTO85_RS04770	COG1420	regulation of RNA biosynthetic process
GTO85_RS04775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTO85_RS04780	COG0443	Heat shock 70 kDa protein
GTO85_RS04785	COG0484	heat shock protein binding
GTO85_RS04790	COG0481	GTPase activity
GTO85_RS04795	COG3764	Sortase (surface protein transpeptidase)
GTO85_RS04800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTO85_RS04800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GTO85_RS04835	COG1396	sequence-specific DNA binding
GTO85_RS04865	COG3620	sequence-specific DNA binding
GTO85_RS05115	COG1388	LysM domain
GTO85_RS05115	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO85_RS05220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTO85_RS05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTO85_RS05260	COG0583	DNA-binding transcription factor activity
GTO85_RS05265	COG2235	arginine
GTO85_RS05270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GTO85_RS05320	COG1132	(ABC) transporter
GTO85_RS05360	COG0527	aspartate kinase activity
GTO85_RS05375	COG0083	homoserine kinase activity
GTO85_RS05385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTO85_RS05430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTO85_RS05565	COG0740	serine-type endopeptidase activity
GTO85_RS05610	COG5280	Phage tail tape measure protein TP901
GTO85_RS05610	COG3953	SLT domain
GTO85_RS05675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTO85_RS05700	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GTO85_RS05705	COG1518	maintenance of DNA repeat elements
GTO85_RS05720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTO85_RS05725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTO85_RS05735	COG0719	Fe-S assembly protein
GTO85_RS05740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTO85_RS05745	COG0822	iron-sulfur transferase activity
GTO85_RS05750	COG0719	Fe-S assembly protein
GTO85_RS05755	COG2151	metal-sulfur cluster biosynthetic enzyme
GTO85_RS05760	COG1914	H( )-stimulated, divalent metal cation uptake system
GTO85_RS05770	COG1702	phosphate starvation-inducible protein PhoH
GTO85_RS05775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GTO85_RS05780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTO85_RS05785	COG1381	Involved in DNA repair and RecF pathway recombination
GTO85_RS05790	COG0752	glycyl-tRNA synthetase alpha subunit
GTO85_RS05795	COG0751	glycine-tRNA ligase activity
GTO85_RS05800	COG0358	DNA primase activity
GTO85_RS05805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTO85_RS05820	COG2384	SAM-dependent methyltransferase
GTO85_RS05825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTO85_RS05830	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTO85_RS05835	COG1725	Transcriptional regulator
GTO85_RS05840	COG1131	(ABC) transporter
GTO85_RS05860	COG0393	Putative heavy-metal-binding
GTO85_RS05885	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GTO85_RS05885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTO85_RS05890	COG0561	phosphatase activity
GTO85_RS05895	COG1304	FMN binding
GTO85_RS05915	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GTO85_RS05920	COG1074	ATP-dependent DNA helicase activity
GTO85_RS05935	COG0017	Asparaginyl-tRNA synthetase
GTO85_RS05945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTO85_RS05950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTO85_RS05955	COG3331	DNA recombination
GTO85_RS05960	COG4474	Belongs to the UPF0398 family
GTO85_RS05965	COG3599	regulation of cell shape
GTO85_RS05975	COG0116	Belongs to the methyltransferase superfamily
GTO85_RS05990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTO85_RS06020	COG1335	isochorismatase
GTO85_RS06030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTO85_RS06035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTO85_RS06040	COG0187	DNA topoisomerase II activity
GTO85_RS06050	COG0583	DNA-binding transcription factor activity
GTO85_RS06055	COG1227	inorganic diphosphatase activity
GTO85_RS06100	COG1193	negative regulation of DNA recombination
GTO85_RS06105	COG1307	EDD domain protein, DegV family
GTO85_RS06120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTO85_RS06125	COG0505	Belongs to the CarA family
GTO85_RS06130	COG0564	pseudouridine synthase activity
GTO85_RS06140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GTO85_RS06255	COG1653	transport
GTO85_RS06265	COG0366	Alpha amylase catalytic
GTO85_RS06270	COG2188	Transcriptional regulator
GTO85_RS06285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTO85_RS06290	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTO85_RS06320	COG0110	maltose O-acetyltransferase activity
GTO85_RS06330	COG0671	phosphoesterase, PA-phosphatase related
GTO85_RS06335	COG2040	homocysteine
GTO85_RS06340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTO85_RS06350	COG0514	ATP-dependent DNA helicase (RecQ)
GTO85_RS06355	COG0110	maltose O-acetyltransferase activity
GTO85_RS06360	COG2159	amidohydrolase
GTO85_RS06370	COG0667	Aldo Keto reductase
GTO85_RS06375	COG0789	Transcriptional regulator
GTO85_RS06385	COG0569	domain protein
GTO85_RS06390	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GTO85_RS06400	COG0531	amino acid
GTO85_RS06415	COG0833	amino acid
GTO85_RS06425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTO85_RS06430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTO85_RS06470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GTO85_RS06485	COG0732	type I restriction modification DNA specificity domain
GTO85_RS06510	COG0656	L-ascorbic acid biosynthetic process
GTO85_RS06520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTO85_RS06535	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GTO85_RS06540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTO85_RS06545	COG0758	DNA mediated transformation
GTO85_RS06550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTO85_RS06555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTO85_RS06565	COG0025	NhaP-type Na H and K H
GTO85_RS06575	COG4479	Belongs to the UPF0346 family
GTO85_RS06580	COG1307	EDD domain protein, DegV family
GTO85_RS06585	COG1272	protein, Hemolysin III
GTO85_RS06590	COG0617	tRNA 3'-terminal CCA addition
GTO85_RS06595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTO85_RS06735	COG1160	GTP binding
GTO85_RS06740	COG0539	negative regulation of cytoplasmic translation
GTO85_RS06745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTO85_RS06755	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GTO85_RS06760	COG1187	pseudouridine synthase activity
GTO85_RS06765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GTO85_RS06770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GTO85_RS06785	COG2996	Protein conserved in bacteria
GTO85_RS06795	COG0205	6-phosphofructokinase activity
GTO85_RS06800	COG0587	DNA-directed DNA polymerase activity
GTO85_RS06810	COG0737	Belongs to the 5'-nucleotidase family
GTO85_RS06815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTO85_RS06825	COG0300	oxidoreductase activity
GTO85_RS06830	COG1234	tRNA 3'-trailer cleavage
GTO85_RS06835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GTO85_RS06835	COG2755	lipolytic protein G-D-S-L family
GTO85_RS06840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTO85_RS06845	COG0322	excinuclease ABC activity
GTO85_RS06855	COG0586	Pfam SNARE associated Golgi protein
GTO85_RS06860	COG0531	amino acid
GTO85_RS06865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTO85_RS06870	COG0561	phosphatase activity
GTO85_RS06875	COG0656	L-ascorbic acid biosynthetic process
GTO85_RS06890	COG0436	Aminotransferase
GTO85_RS06895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTO85_RS06900	COG0124	histidyl-tRNA synthetase
GTO85_RS06905	COG1490	D-aminoacyl-tRNA deacylase activity
GTO85_RS06910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTO85_RS06920	COG2264	protein methyltransferase activity
GTO85_RS06925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTO85_RS06950	COG4720	Psort location CytoplasmicMembrane, score
GTO85_RS06955	COG1122	ATPase activity
GTO85_RS06970	COG2707	UPF0756 membrane protein
GTO85_RS06985	COG3052	prosthetic group binding
GTO85_RS06995	COG2267	carboxylic ester hydrolase activity
GTO85_RS07005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTO85_RS07010	COG3579	cysteine-type endopeptidase activity
GTO85_RS07015	COG0039	L-malate dehydrogenase activity
GTO85_RS07020	COG1053	succinate dehydrogenase
GTO85_RS07025	COG0114	fumarate hydratase activity
GTO85_RS07030	COG2011	ABC-type metal ion transport system permease component
GTO85_RS07035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTO85_RS07050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTO85_RS07055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTO85_RS07060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GTO85_RS07065	COG1113	amino acid transport
GTO85_RS07070	COG1132	(ABC) transporter
GTO85_RS07115	COG0583	DNA-binding transcription factor activity
GTO85_RS07130	COG1063	alcohol dehydrogenase
GTO85_RS07140	COG0583	DNA-binding transcription factor activity
GTO85_RS07155	COG0656	L-ascorbic acid biosynthetic process
GTO85_RS07160	COG0667	Aldo Keto reductase
GTO85_RS07210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTO85_RS07220	COG1114	Component of the transport system for branched-chain amino acids
GTO85_RS07225	COG1051	belongs to the nudix hydrolase family
GTO85_RS07245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTO85_RS07245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTO85_RS07250	COG0307	riboflavin synthase, alpha
GTO85_RS07255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTO85_RS07255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTO85_RS07260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTO85_RS07280	COG1215	transferase activity, transferring glycosyl groups
GTO85_RS07300	COG1011	Hydrolase
GTO85_RS07305	COG0783	Belongs to the Dps family
GTO85_RS07320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTO85_RS07340	COG2855	membrane
GTO85_RS07350	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GTO85_RS07365	COG0148	phosphopyruvate hydratase activity
GTO85_RS07385	COG2723	6-phospho-beta-galactosidase activity
GTO85_RS07390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS07395	COG2188	Transcriptional regulator
GTO85_RS07400	COG2723	6-phospho-beta-galactosidase activity
GTO85_RS07410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS07420	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTO85_RS07425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS07430	COG2188	Transcriptional regulator
GTO85_RS07435	COG2723	6-phospho-beta-galactosidase activity
GTO85_RS07445	COG1957	nucleoside hydrolase
GTO85_RS07455	COG0431	NADPH-dependent FMN reductase
GTO85_RS07455	COG1053	succinate dehydrogenase
GTO85_RS07455	COG3976	FMN-binding domain protein
GTO85_RS07465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTO85_RS07470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTO85_RS07475	COG0436	Aminotransferase
GTO85_RS07480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTO85_RS07485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTO85_RS07490	COG1473	amidohydrolase
GTO85_RS07495	COG2171	N-acyltransferase activity
GTO85_RS07500	COG0019	diaminopimelate decarboxylase activity
GTO85_RS07505	COG0527	aspartate kinase activity
GTO85_RS07510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTO85_RS07520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GTO85_RS07525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTO85_RS07530	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTO85_RS07535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTO85_RS07550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTO85_RS07555	COG0268	Binds directly to 16S ribosomal RNA
GTO85_RS07560	COG1466	dna polymerase III delta subunit
GTO85_RS07565	COG0658	competence protein
GTO85_RS07565	COG2333	competence protein COMEC
GTO85_RS07570	COG1555	photosystem II stabilization
GTO85_RS07575	COG3480	Lon protease (S16) C-terminal proteolytic domain
GTO85_RS07580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTO85_RS07585	COG0742	ribosomal rna small subunit methyltransferase
GTO85_RS07590	COG4471	UPF0298 protein
GTO85_RS07595	COG0772	Belongs to the SEDS family
GTO85_RS07605	COG0242	peptide deformylase activity
GTO85_RS07620	COG1597	lipid kinase activity
GTO85_RS07630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTO85_RS07640	COG0406	alpha-ribazole phosphatase activity
GTO85_RS07645	COG0482	sulfurtransferase activity
GTO85_RS07655	COG1104	cysteine desulfurase activity
GTO85_RS07670	COG0494	nUDIX hydrolase
GTO85_RS07675	COG1278	Cold shock
GTO85_RS07680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GTO85_RS07700	COG1799	cell septum assembly
GTO85_RS07705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTO85_RS07715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTO85_RS07720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTO85_RS07725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTO85_RS07730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTO85_RS07745	COG0275	rRNA processing
GTO85_RS07750	COG2001	Belongs to the MraZ family
GTO85_RS07770	COG1792	Involved in formation and maintenance of cell shape
GTO85_RS07775	COG1077	Cell shape determining protein MreB Mrl
GTO85_RS07780	COG2003	Belongs to the UPF0758 family
GTO85_RS07785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTO85_RS07795	COG0525	valine-tRNA ligase activity
GTO85_RS07810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTO85_RS07830	COG0463	Glycosyl transferase, family 2
GTO85_RS07845	COG1187	pseudouridine synthase activity
GTO85_RS07910	COG0301	tRNA thio-modification
GTO85_RS07915	COG1104	cysteine desulfurase activity
GTO85_RS07920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GTO85_RS07925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTO85_RS07935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTO85_RS07945	COG0589	response to stress
GTO85_RS07950	COG1523	belongs to the glycosyl hydrolase 13 family
GTO85_RS07960	COG0772	Belongs to the SEDS family
GTO85_RS07970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GTO85_RS07985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTO85_RS07990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTO85_RS07995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTO85_RS08000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTO85_RS08005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTO85_RS08010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTO85_RS08015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTO85_RS08020	COG0356	it plays a direct role in the translocation of protons across the membrane
GTO85_RS08025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTO85_RS08030	COG0009	L-threonylcarbamoyladenylate synthase
GTO85_RS08035	COG2890	protein-(glutamine-N5) methyltransferase activity
GTO85_RS08040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTO85_RS08045	COG1435	thymidine kinase activity
GTO85_RS08050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTO85_RS08055	COG0582	viral genome integration into host DNA
GTO85_RS08115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTO85_RS08120	COG0477	Major facilitator Superfamily
GTO85_RS08125	COG0166	Belongs to the GPI family
GTO85_RS08135	COG1368	sulfuric ester hydrolase activity
GTO85_RS08140	COG3850	Histidine kinase
GTO85_RS08140	COG5002	protein histidine kinase activity
GTO85_RS08145	COG0745	RESPONSE REGULATOR receiver
GTO85_RS08155	COG1482	cell wall glycoprotein biosynthetic process
GTO85_RS08160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GTO85_RS08175	COG2337	Toxic component of a toxin-antitoxin (TA) module
GTO85_RS08240	COG3953	SLT domain
GTO85_RS08240	COG5280	Phage tail tape measure protein TP901
GTO85_RS08425	COG3617	BRO family, N-terminal domain
GTO85_RS08455	COG4974	Belongs to the 'phage' integrase family
GTO85_RS08470	COG0827	DNA restriction-modification system
GTO85_RS08505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTO85_RS08510	COG0217	transcriptional regulatory protein
GTO85_RS08530	COG0531	amino acid
GTO85_RS08545	COG1263	PTS System
GTO85_RS08545	COG2190	(PTS) system
GTO85_RS08545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTO85_RS08555	COG1929	Belongs to the glycerate kinase type-1 family
GTO85_RS08560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTO85_RS08575	COG0561	phosphatase activity
GTO85_RS08580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTO85_RS08585	COG4856	YbbR-like protein
GTO85_RS08605	COG1176	ABC-type spermidine putrescine transport system, permease component I
GTO85_RS08610	COG3842	ATPase activity
GTO85_RS08615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTO85_RS08625	COG0802	atpase or kinase
GTO85_RS08630	COG0280	phosphate acetyltransferase
GTO85_RS08635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTO85_RS08640	COG0561	phosphatase activity
GTO85_RS08650	COG0149	triose-phosphate isomerase activity
GTO85_RS08655	COG0126	phosphoglycerate kinase activity
GTO85_RS08665	COG2390	Transcriptional regulator
GTO85_RS08680	COG0531	amino acid
GTO85_RS08695	COG2814	Major facilitator Superfamily
GTO85_RS08705	COG0390	transport system, permease component
GTO85_RS08710	COG4619	ABC transporter
GTO85_RS08720	COG0740	serine-type endopeptidase activity
GTO85_RS08730	COG1481	regulation of sporulation
GTO85_RS08735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTO85_RS08740	COG1660	Displays ATPase and GTPase activities
GTO85_RS08750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTO85_RS08755	COG0556	nucleotide-excision repair
GTO85_RS08760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTO85_RS08765	COG0492	ferredoxin-NADP+ reductase activity
GTO85_RS08770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTO85_RS08775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTO85_RS08780	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GTO85_RS08795	COG0653	protein targeting
GTO85_RS08810	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GTO85_RS08815	COG1739	Uncharacterized protein family UPF0029
GTO85_RS08820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTO85_RS08825	COG1418	mRNA catabolic process
GTO85_RS08830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTO85_RS08835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTO85_RS08840	COG1426	Protein conserved in bacteria
GTO85_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
GTO85_RS08850	COG0612	Peptidase, M16
GTO85_RS08860	COG1674	ftsk spoiiie
GTO85_RS08860	COG1280	lysine exporter protein (LysE YggA)
GTO85_RS08875	COG0628	permease
GTO85_RS08885	COG2706	6-phosphogluconolactonase activity
GTO85_RS08900	COG0564	pseudouridine synthase activity
GTO85_RS08905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTO85_RS08910	COG2357	RelA SpoT domain protein
GTO85_RS08930	COG4862	establishment of competence for transformation
GTO85_RS08935	COG1393	Belongs to the ArsC family
GTO85_RS08945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTO85_RS08955	COG0542	response to heat
GTO85_RS08980	COG1132	(ABC) transporter
GTO85_RS08990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GTO85_RS09015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTO85_RS09030	COG3425	synthase
GTO85_RS09040	COG0183	Belongs to the thiolase family
GTO85_RS09045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTO85_RS09050	COG1295	ribonuclease BN
GTO85_RS09055	COG0024	Methionine aminopeptidase
GTO85_RS09060	COG0716	FMN binding
GTO85_RS09075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTO85_RS09090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS09105	COG0531	amino acid
GTO85_RS09110	COG1053	succinate dehydrogenase
GTO85_RS09110	COG3976	FMN-binding domain protein
GTO85_RS09120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTO85_RS09125	COG0583	DNA-binding transcription factor activity
GTO85_RS09140	COG1053	succinate dehydrogenase
GTO85_RS09150	COG1253	flavin adenine dinucleotide binding
GTO85_RS09165	COG1263	PTS System
GTO85_RS09165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTO85_RS09165	COG2190	(PTS) system
GTO85_RS09175	COG1737	Transcriptional regulator
GTO85_RS09180	COG1263	PTS System
GTO85_RS09180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTO85_RS09185	COG0561	phosphatase activity
GTO85_RS09195	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GTO85_RS09210	COG0561	phosphatase activity
GTO85_RS09215	COG2188	Transcriptional regulator
GTO85_RS09225	COG3158	transport of potassium into the cell
GTO85_RS09230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTO85_RS09265	COG0765	amino acid transport
GTO85_RS09270	COG0765	amino acid transport
GTO85_RS09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO85_RS09285	COG0572	uridine kinase
GTO85_RS09305	COG1132	(ABC) transporter
GTO85_RS09310	COG1132	(ABC) transporter
GTO85_RS09320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO85_RS09325	COG0519	Catalyzes the synthesis of GMP from XMP
GTO85_RS09330	COG0531	amino acid
GTO85_RS09355	COG4989	oxidoreductase activity
GTO85_RS09360	COG0488	(ABC) transporter
GTO85_RS09385	COG2814	Major facilitator Superfamily
GTO85_RS09405	COG0656	L-ascorbic acid biosynthetic process
GTO85_RS09420	COG4716	Myosin-crossreactive antigen
GTO85_RS09430	COG2814	Major facilitator Superfamily
GTO85_RS09460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTO85_RS09510	COG1132	(ABC) transporter
GTO85_RS09515	COG1597	lipid kinase activity
GTO85_RS09520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTO85_RS09525	COG0154	amidase activity
GTO85_RS09530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTO85_RS09535	COG4851	CamS sex pheromone cAM373 precursor
GTO85_RS09540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTO85_RS09550	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTO85_RS09560	COG3091	SprT-like family
GTO85_RS09575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTO85_RS09600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTO85_RS09605	COG1609	Transcriptional regulator
GTO85_RS09615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTO85_RS09625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GTO85_RS09635	COG2188	Transcriptional regulator
GTO85_RS09645	COG4166	transmembrane transport
GTO85_RS09650	COG0582	viral genome integration into host DNA
GTO85_RS09735	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTO85_RS09755	COG1737	Transcriptional regulator
GTO85_RS09760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTO85_RS09765	COG0673	inositol 2-dehydrogenase activity
GTO85_RS09770	COG0436	Aminotransferase
GTO85_RS09780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTO85_RS09805	COG0584	glycerophosphoryl diester phosphodiesterase
GTO85_RS09815	COG0588	phosphoglycerate mutase activity
GTO85_RS09875	COG0778	Nitroreductase
GTO85_RS09895	COG1111	helicase
GTO85_RS09895	COG1205	dead DEAH box helicase
GTO85_RS09910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTO85_RS09920	COG0494	nUDIX hydrolase
GTO85_RS09935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTO85_RS09955	COG3436	PFAM IS66 Orf2 family protein
GTO85_RS09995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTO85_RS10000	COG1454	alcohol dehydrogenase
GTO85_RS10000	COG1012	belongs to the aldehyde dehydrogenase family
GTO85_RS10005	COG1113	amino acid transport
GTO85_RS10010	COG0110	maltose O-acetyltransferase activity
GTO85_RS10015	COG0583	DNA-binding transcription factor activity
GTO85_RS10025	COG3716	PTS system mannose fructose sorbose family IID component
GTO85_RS10030	COG3715	PTS system
GTO85_RS10080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTO85_RS10085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTO85_RS10090	COG0398	Pfam SNARE associated Golgi protein
GTO85_RS10110	COG1012	belongs to the aldehyde dehydrogenase family
GTO85_RS10120	COG2409	Drug exporters of the RND superfamily
GTO85_RS10120	COG1033	growth of symbiont in host cell
GTO85_RS10155	COG1175	transmembrane transport
GTO85_RS10175	COG2176	DNA-directed DNA polymerase activity
GTO85_RS10215	COG1132	(ABC) transporter
GTO85_RS10220	COG2267	carboxylic ester hydrolase activity
GTO85_RS10235	COG1846	Transcriptional regulator
GTO85_RS10240	COG4166	transmembrane transport
GTO85_RS10255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTO85_RS10260	COG1072	(Pantothenic acid kinase))
GTO85_RS10270	COG2153	protein acetylation
GTO85_RS10275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTO85_RS10280	COG1126	abc transporter atp-binding protein
GTO85_RS10285	COG0765	amino acid transport
GTO85_RS10290	COG3973	AAA domain
GTO85_RS10300	COG0588	phosphoglycerate mutase activity
GTO85_RS10335	COG0252	asparaginase activity
GTO85_RS10380	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GTO85_RS10450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTO85_RS10470	COG1216	Glycosyl transferase, family 2
GTO85_RS10490	COG1216	Glycosyl transferase, family 2
GTO85_RS10495	COG3955	Domain of unknown function (DUF1919)
GTO85_RS10500	COG0438	transferase activity, transferring glycosyl groups
GTO85_RS10510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTO85_RS10520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTO85_RS10525	COG4464	protein tyrosine phosphatase activity
GTO85_RS10530	COG0489	protein tyrosine kinase activity
GTO85_RS10540	COG1316	TRANSCRIPTIONal
GTO85_RS10545	COG4115	mRNA cleavage
GTO85_RS10550	COG3077	Addiction module antitoxin, RelB DinJ family
GTO85_RS10555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTO85_RS10570	COG0791	NLP P60 protein
GTO85_RS10575	COG0791	NLP P60 protein
GTO85_RS10580	COG0791	NLP P60 protein
GTO85_RS10585	COG0194	GDP metabolic process
GTO85_RS10605	COG1780	Probably involved in ribonucleotide reductase function
GTO85_RS10620	COG4990	cell redox homeostasis
GTO85_RS10635	COG0488	(ABC) transporter
GTO85_RS10645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTO85_RS10655	COG1811	Na channel or pump
GTO85_RS10660	COG1316	TRANSCRIPTIONal
GTO85_RS10665	COG1164	Oligoendopeptidase f
GTO85_RS10695	COG1476	TRANSCRIPTIONal
GTO85_RS10705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTO85_RS10710	COG1854	S-ribosylhomocysteine lyase activity
GTO85_RS10715	COG1620	l-lactate permease
GTO85_RS10725	COG1121	(ABC) transporter
GTO85_RS10730	COG0803	Belongs to the bacterial solute-binding protein 9 family
GTO85_RS10735	COG0640	Transcriptional regulator
GTO85_RS10740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTO85_RS10740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTO85_RS10740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTO85_RS10745	COG1105	Belongs to the carbohydrate kinase PfkB family
GTO85_RS10755	COG1668	transmembrane transport
GTO85_RS10760	COG4152	abc transporter atp-binding protein
GTO85_RS10785	COG3655	Transcriptional regulator
GTO85_RS10825	COG2274	protein secretion by the type I secretion system
GTO85_RS10855	COG0463	Glycosyl transferase, family 2
GTO85_RS10855	COG0457	Tetratricopeptide repeat
GTO85_RS10870	COG3279	Response regulator of the LytR AlgR family
GTO85_RS10920	COG0277	FAD linked oxidase domain protein
GTO85_RS10940	COG1794	racemase activity, acting on amino acids and derivatives
GTO85_RS10945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTO85_RS10965	COG1132	(ABC) transporter
GTO85_RS10970	COG1132	(ABC) transporter
GTO85_RS10980	COG0012	GTP binding
GTO85_RS10985	COG4481	Protein conserved in bacteria
GTO85_RS10990	COG1475	DNA binding
GTO85_RS10995	COG1192	Involved in chromosome partitioning
GTO85_RS11000	COG1475	DNA binding
GTO85_RS11005	COG0357	Ribosomal RNA small subunit methyltransferase G
GTO85_RS11025	COG0431	NADPH-dependent FMN reductase
GTO85_RS11030	COG0431	NADPH-dependent FMN reductase
GTO85_RS11050	COG0626	cystathionine gamma-synthase activity
GTO85_RS11055	COG0626	cystathionine gamma-synthase activity
GTO85_RS11060	COG1464	Belongs to the NlpA lipoprotein family
GTO85_RS11065	COG1136	(ABC) transporter
GTO85_RS11080	COG0406	alpha-ribazole phosphatase activity
GTO85_RS11090	COG3022	response to hydroperoxide
GTO85_RS11100	COG3104	oligopeptide transport
GTO85_RS11130	COG3104	oligopeptide transport
GTO85_RS11135	COG0308	aminopeptidase N
GTO85_RS11170	COG4555	ABC transporter
GTO85_RS11185	COG3833	ABC-type maltose transport systems, permease component
GTO85_RS11190	COG1175	transmembrane transport
GTO85_RS11200	COG3842	ATPase activity
GTO85_RS11205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTO85_RS11220	COG0366	Alpha amylase catalytic
GTO85_RS11230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTO85_RS11235	COG1609	Transcriptional regulator
GTO85_RS11245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTO85_RS11250	COG0351	phosphomethylpyrimidine kinase
GTO85_RS11275	COG3442	glutamine amidotransferase
GTO85_RS11310	COG0697	spore germination
GTO85_RS11330	COG0488	(ABC) transporter
GTO85_RS11350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTO85_RS11355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GTO85_RS11360	COG0516	GMP reductase activity
GTO85_RS11380	COG2502	aspartate--ammonia ligase
GTO85_RS11430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GTO85_RS11450	COG1113	amino acid transport
GTO85_RS11455	COG1113	amino acid transport
GTO85_RS11460	COG0681	Belongs to the peptidase S26 family
GTO85_RS11465	COG0542	response to heat
GTO85_RS11495	COG2244	polysaccharide biosynthetic process
GTO85_RS11515	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GTO85_RS11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTO85_RS11525	COG1696	Membrane protein involved in D-alanine export
GTO85_RS11530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTO85_RS11550	COG0517	IMP dehydrogenase activity
GTO85_RS11550	COG0516	GMP reductase activity
GTO85_RS11555	COG2217	Heavy metal translocating P-type atpase
GTO85_RS11575	COG2161	toxin-antitoxin pair type II binding
GTO85_RS11580	COG4115	mRNA cleavage
GTO85_RS11605	COG1396	sequence-specific DNA binding
GTO85_RS11620	COG1136	(ABC) transporter
GTO85_RS11620	COG0577	efflux transmembrane transporter activity
GTO85_RS11625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GTO85_RS11635	COG1744	ABC transporter substrate-binding protein PnrA-like
GTO85_RS11640	COG1744	ABC transporter substrate-binding protein PnrA-like
GTO85_RS11660	COG0656	L-ascorbic acid biosynthetic process
GTO85_RS11665	COG0363	glucosamine-6-phosphate deaminase activity
GTO85_RS11670	COG1428	Deoxynucleoside kinase
GTO85_RS11675	COG1428	Deoxynucleoside kinase
GTO85_RS11690	COG2252	PERMEase
GTO85_RS11695	COG1373	ATPase (AAA superfamily
GTO85_RS11700	COG0789	Transcriptional regulator
GTO85_RS11705	COG2252	PERMEase
GTO85_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
GTO85_RS11740	COG1373	ATPase (AAA superfamily
GTO85_RS11750	COG2252	PERMEase
GTO85_RS11770	COG2217	Heavy metal translocating P-type atpase
GTO85_RS11775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTO85_RS11785	COG0477	Major facilitator Superfamily
GTO85_RS11815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTO85_RS11825	COG0588	phosphoglycerate mutase activity
GTO85_RS11835	COG2222	sugar isomerase
GTO85_RS11840	COG3716	PTS system mannose fructose sorbose family IID component
GTO85_RS11845	COG3715	PTS system
GTO85_RS11875	COG0028	Belongs to the TPP enzyme family
GTO85_RS11880	COG0445	tRNA wobble uridine modification
GTO85_RS11885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTO85_RS11890	COG0706	membrane insertase activity
GTO85_RS11895	COG0594	ribonuclease P activity
GTO85_RS11900	COG0230	Belongs to the bacterial ribosomal protein bL34 family