locus-tag	class	description
D7I45_RS00010	COG1518	maintenance of DNA repeat elements
D7I45_RS00015	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D7I45_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
D7I45_RS00090	COG1253	flavin adenine dinucleotide binding
D7I45_RS00100	COG2814	Major facilitator Superfamily
D7I45_RS00110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D7I45_RS00115	COG2132	Multicopper oxidase
D7I45_RS00140	COG0183	Belongs to the thiolase family
D7I45_RS00155	COG1376	ErfK ybiS ycfS ynhG family protein
D7I45_RS00170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7I45_RS00175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7I45_RS00185	COG2814	Major facilitator Superfamily
D7I45_RS00195	COG0589	response to stress
D7I45_RS00205	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D7I45_RS00220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7I45_RS00225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D7I45_RS00240	COG5002	protein histidine kinase activity
D7I45_RS00245	COG0745	RESPONSE REGULATOR receiver
D7I45_RS00285	COG1328	CTP reductase activity
D7I45_RS00295	COG0396	ATPase activity
D7I45_RS00300	COG0719	Fe-S assembly protein
D7I45_RS00305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7I45_RS00315	COG0719	Fe-S assembly protein
D7I45_RS00320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D7I45_RS00325	COG4166	transmembrane transport
D7I45_RS00330	COG2814	Major facilitator Superfamily
D7I45_RS00335	COG0305	Participates in initiation and elongation during chromosome replication
D7I45_RS00340	COG0359	binds to the 23S rRNA
D7I45_RS00355	COG0629	single-stranded DNA binding
D7I45_RS00360	COG0360	Binds together with S18 to 16S ribosomal RNA
D7I45_RS00370	COG0187	DNA topoisomerase II activity
D7I45_RS00375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D7I45_RS00380	COG2501	S4 domain
D7I45_RS00390	COG0592	DNA-directed DNA polymerase activity
D7I45_RS00395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7I45_RS00405	COG0594	ribonuclease P activity
D7I45_RS00410	COG0706	membrane insertase activity
D7I45_RS00415	COG1847	R3H domain protein
D7I45_RS00420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D7I45_RS00425	COG0445	tRNA wobble uridine modification
D7I45_RS00450	COG0765	amino acid transport
D7I45_RS00455	COG1126	abc transporter atp-binding protein
D7I45_RS00485	COG4166	transmembrane transport
D7I45_RS00500	COG2814	Major facilitator Superfamily
D7I45_RS00505	COG2814	Major facilitator Superfamily
D7I45_RS00520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7I45_RS00535	COG0346	lactoylglutathione lyase activity
D7I45_RS00540	COG1063	alcohol dehydrogenase
D7I45_RS00545	COG1940	carbohydrate kinase activity
D7I45_RS00550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7I45_RS00555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7I45_RS00575	COG2252	PERMEase
D7I45_RS00580	COG0667	Aldo Keto reductase
D7I45_RS00600	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D7I45_RS00605	COG1074	ATP-dependent DNA helicase activity
D7I45_RS00610	COG1012	belongs to the aldehyde dehydrogenase family
D7I45_RS00610	COG1454	alcohol dehydrogenase
D7I45_RS00635	COG2855	membrane
D7I45_RS00645	COG0477	Major facilitator Superfamily
D7I45_RS00655	COG1126	abc transporter atp-binding protein
D7I45_RS00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7I45_RS00675	COG0583	DNA-binding transcription factor activity
D7I45_RS00680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7I45_RS00685	COG1126	abc transporter atp-binding protein
D7I45_RS00690	COG0765	amino acid transport
D7I45_RS00695	COG0668	transmembrane transport
D7I45_RS00700	COG0668	transmembrane transport
D7I45_RS00710	COG0577	efflux transmembrane transporter activity
D7I45_RS00710	COG1136	(ABC) transporter
D7I45_RS00725	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7I45_RS00740	COG1136	(ABC) transporter
D7I45_RS00780	COG0584	glycerophosphoryl diester phosphodiesterase
D7I45_RS00805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D7I45_RS00810	COG1476	TRANSCRIPTIONal
D7I45_RS00820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7I45_RS00820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7I45_RS00825	COG0307	riboflavin synthase, alpha
D7I45_RS00835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7I45_RS00840	COG0308	aminopeptidase N
D7I45_RS00870	COG2814	Major facilitator Superfamily
D7I45_RS00905	COG0693	protein deglycase activity
D7I45_RS00915	COG3527	Alpha-acetolactate decarboxylase
D7I45_RS00935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7I45_RS00940	COG4166	transmembrane transport
D7I45_RS00945	COG4166	transmembrane transport
D7I45_RS00975	COG0114	fumarate hydratase activity
D7I45_RS01000	COG1704	LemA family
D7I45_RS01015	COG1114	Component of the transport system for branched-chain amino acids
D7I45_RS01030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7I45_RS01050	COG1316	TRANSCRIPTIONal
D7I45_RS01055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7I45_RS01070	COG0562	UDP-galactopyranose mutase
D7I45_RS01075	COG0438	transferase activity, transferring glycosyl groups
D7I45_RS01080	COG1215	transferase activity, transferring glycosyl groups
D7I45_RS01085	COG0562	UDP-galactopyranose mutase
D7I45_RS01090	COG2244	polysaccharide biosynthetic process
D7I45_RS01095	COG2814	Major facilitator Superfamily
D7I45_RS01100	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7I45_RS01110	COG0531	amino acid
D7I45_RS01115	COG1113	amino acid transport
D7I45_RS01120	COG1113	amino acid transport
D7I45_RS01125	COG1846	Transcriptional regulator
D7I45_RS01140	COG1131	(ABC) transporter
D7I45_RS01150	COG1272	protein, Hemolysin III
D7I45_RS01165	COG2323	membrane
D7I45_RS01195	COG0702	epimerase
D7I45_RS01200	COG0488	(ABC) transporter
D7I45_RS01220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7I45_RS01225	COG0778	Nitroreductase
D7I45_RS01230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7I45_RS01235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7I45_RS01240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7I45_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
D7I45_RS01255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7I45_RS01260	COG0439	Biotin carboxylase
D7I45_RS01265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D7I45_RS01270	COG0825	malonyl-CoA metabolic process
D7I45_RS01275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7I45_RS01285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7I45_RS01290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7I45_RS01295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7I45_RS01300	COG0656	L-ascorbic acid biosynthetic process
D7I45_RS01305	COG0697	spore germination
D7I45_RS01315	COG1033	growth of symbiont in host cell
D7I45_RS01315	COG2409	Drug exporters of the RND superfamily
D7I45_RS01320	COG2364	Membrane
D7I45_RS01325	COG0531	amino acid
D7I45_RS01330	COG0697	spore germination
D7I45_RS01335	COG0697	spore germination
D7I45_RS01365	COG1278	Cold shock
D7I45_RS01375	COG4608	Belongs to the ABC transporter superfamily
D7I45_RS01380	COG0601	transmembrane transport
D7I45_RS01395	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7I45_RS01415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7I45_RS01420	COG0351	phosphomethylpyrimidine kinase
D7I45_RS01425	COG0328	RNA-DNA hybrid ribonuclease activity
D7I45_RS01425	COG3341	Caulimovirus viroplasmin
D7I45_RS01430	COG0110	maltose O-acetyltransferase activity
D7I45_RS01440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7I45_RS01445	COG0024	Methionine aminopeptidase
D7I45_RS01455	COG2814	Major facilitator Superfamily
D7I45_RS01465	COG3590	peptidase
D7I45_RS01495	COG4946	Tricorn protease homolog
D7I45_RS01495	COG1506	peptidase
D7I45_RS01495	COG0823	Involved in the tonB-independent uptake of proteins
D7I45_RS01505	COG1464	Belongs to the NlpA lipoprotein family
D7I45_RS01510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7I45_RS01535	COG2814	Major facilitator Superfamily
D7I45_RS01540	COG0735	belongs to the Fur family
D7I45_RS01550	COG2706	6-phosphogluconolactonase activity
D7I45_RS01565	COG1309	transcriptional regulator
D7I45_RS01575	COG1307	EDD domain protein, DegV family
D7I45_RS01595	COG2233	PERMEase
D7I45_RS01620	COG1122	ATPase activity
D7I45_RS01625	COG4721	ABC-type cobalt transport system, permease component
D7I45_RS01630	COG1686	Belongs to the peptidase S11 family
D7I45_RS01650	COG1881	PFAM PEBP family protein
D7I45_RS01660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7I45_RS01665	COG4120	Belongs to the binding-protein-dependent transport system permease family
D7I45_RS01675	COG0531	amino acid
D7I45_RS01685	COG0488	(ABC) transporter
D7I45_RS01695	COG2267	carboxylic ester hydrolase activity
D7I45_RS01700	COG2936	dipeptidyl-peptidase activity
D7I45_RS01710	COG0194	GDP metabolic process
D7I45_RS01725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7I45_RS01730	COG4166	transmembrane transport
D7I45_RS01735	COG4166	transmembrane transport
D7I45_RS01740	COG0601	transmembrane transport
D7I45_RS01745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7I45_RS01750	COG0444	Belongs to the ABC transporter superfamily
D7I45_RS01755	COG4608	Belongs to the ABC transporter superfamily
D7I45_RS01760	COG0588	phosphoglycerate mutase activity
D7I45_RS01765	COG3973	AAA domain
D7I45_RS01770	COG1072	(Pantothenic acid kinase))
D7I45_RS01775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D7I45_RS01775	COG0519	Catalyzes the synthesis of GMP from XMP
D7I45_RS01780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D7I45_RS01785	COG1064	alcohol dehydrogenase
D7I45_RS01800	COG3338	carbonate dehydratase activity
D7I45_RS01805	COG0564	pseudouridine synthase activity
D7I45_RS01825	COG1230	cation diffusion facilitator family transporter
D7I45_RS01875	COG0833	amino acid
D7I45_RS01880	COG1428	Deoxynucleoside kinase
D7I45_RS01885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D7I45_RS01930	COG4463	regulation of RNA biosynthetic process
D7I45_RS01935	COG0542	response to heat
D7I45_RS01940	COG0085	RNA polymerase activity
D7I45_RS01945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D7I45_RS01955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7I45_RS01960	COG0049	tRNA binding
D7I45_RS01965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D7I45_RS01970	COG0051	transcription antitermination factor activity, RNA binding
D7I45_RS01975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D7I45_RS01980	COG0088	Forms part of the polypeptide exit tunnel
D7I45_RS01985	COG0089	rRNA binding
D7I45_RS01990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7I45_RS01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7I45_RS02000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7I45_RS02005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7I45_RS02010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D7I45_RS02025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7I45_RS02030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D7I45_RS02035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7I45_RS02040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7I45_RS02045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7I45_RS02050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D7I45_RS02060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7I45_RS02065	COG1841	ribosomal large subunit assembly
D7I45_RS02070	COG0200	Binds to the 23S rRNA
D7I45_RS02080	COG0563	adenylate kinase activity
D7I45_RS02085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7I45_RS02095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D7I45_RS02100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7I45_RS02105	COG0202	RNA polymerase activity
D7I45_RS02110	COG0203	ribosomal protein L17
D7I45_RS02120	COG1122	ATPase activity
D7I45_RS02125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7I45_RS02130	COG0101	tRNA pseudouridine synthase activity
D7I45_RS02135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7I45_RS02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D7I45_RS02155	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7I45_RS02160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7I45_RS02170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7I45_RS02175	COG4851	CamS sex pheromone cAM373 precursor
D7I45_RS02180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7I45_RS02190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7I45_RS02195	COG1597	lipid kinase activity
D7I45_RS02200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7I45_RS02220	COG0531	amino acid
D7I45_RS02225	COG1070	Carbohydrate kinase
D7I45_RS02230	COG3757	hydrolase, family 25
D7I45_RS02230	COG3409	Peptidoglycan-binding domain 1 protein
D7I45_RS02245	COG4975	Glucose uptake
D7I45_RS02250	COG2610	gluconate transmembrane transporter activity
D7I45_RS02255	COG4166	transmembrane transport
D7I45_RS02265	COG2246	polysaccharide biosynthetic process
D7I45_RS02270	COG0463	Glycosyl transferase, family 2
D7I45_RS02275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D7I45_RS02280	COG1295	ribonuclease BN
D7I45_RS02285	COG0716	FMN binding
D7I45_RS02290	COG2137	regulation of response to DNA damage stimulus
D7I45_RS02295	COG0628	permease
D7I45_RS02300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D7I45_RS02305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D7I45_RS02315	COG0542	response to heat
D7I45_RS02330	COG0438	transferase activity, transferring glycosyl groups
D7I45_RS02335	COG0438	transferase activity, transferring glycosyl groups
D7I45_RS02345	COG1368	sulfuric ester hydrolase activity
D7I45_RS02495	COG1234	tRNA 3'-trailer cleavage
D7I45_RS02500	COG4862	establishment of competence for transformation
D7I45_RS02510	COG1164	Oligoendopeptidase f
D7I45_RS02520	COG2357	RelA SpoT domain protein
D7I45_RS02525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D7I45_RS02530	COG0564	pseudouridine synthase activity
D7I45_RS02535	COG0500	methyltransferase
D7I45_RS02545	COG1674	ftsk spoiiie
D7I45_RS02560	COG2001	Belongs to the MraZ family
D7I45_RS02565	COG0275	rRNA processing
D7I45_RS02575	COG0768	penicillin binding
D7I45_RS02580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7I45_RS02590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7I45_RS02595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7I45_RS02605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7I45_RS02610	COG1799	cell septum assembly
D7I45_RS02620	COG3599	regulation of cell shape
D7I45_RS02625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D7I45_RS02630	COG1278	Cold shock
D7I45_RS02635	COG0494	nUDIX hydrolase
D7I45_RS02645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7I45_RS02650	COG1104	cysteine desulfurase activity
D7I45_RS02660	COG0482	sulfurtransferase activity
D7I45_RS02675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7I45_RS02680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7I45_RS02685	COG0667	Aldo Keto reductase
D7I45_RS02695	COG1597	lipid kinase activity
D7I45_RS02705	COG5503	Protein of unknown function (DUF1447)
D7I45_RS02715	COG0242	peptide deformylase activity
D7I45_RS02725	COG1217	gtp-binding protein TYPA
D7I45_RS02730	COG0772	Belongs to the SEDS family
D7I45_RS02735	COG4471	UPF0298 protein
D7I45_RS02740	COG0742	ribosomal rna small subunit methyltransferase
D7I45_RS02745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7I45_RS02750	COG3480	Lon protease (S16) C-terminal proteolytic domain
D7I45_RS02755	COG1555	photosystem II stabilization
D7I45_RS02755	COG1596	polysaccharide export
D7I45_RS02760	COG2131	deaminase
D7I45_RS02765	COG2333	competence protein COMEC
D7I45_RS02765	COG0658	competence protein
D7I45_RS02770	COG1466	dna polymerase III delta subunit
D7I45_RS02780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D7I45_RS02795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7I45_RS02800	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7I45_RS02805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D7I45_RS02810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D7I45_RS02820	COG0322	excinuclease ABC activity
D7I45_RS02825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7I45_RS02830	COG1234	tRNA 3'-trailer cleavage
D7I45_RS02835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D7I45_RS02835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D7I45_RS02840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7I45_RS02850	COG3425	synthase
D7I45_RS02860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D7I45_RS02865	COG4224	UPF0291 protein
D7I45_RS02870	COG3763	UPF0154 protein
D7I45_RS02875	COG0204	Acyl-transferase
D7I45_RS02880	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D7I45_RS02890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7I45_RS02895	COG0052	Belongs to the universal ribosomal protein uS2 family
D7I45_RS02900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7I45_RS02905	COG0528	UMP kinase activity
D7I45_RS02920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7I45_RS02925	COG4589	Belongs to the CDS family
D7I45_RS02930	COG0750	zinc metalloprotease
D7I45_RS02935	COG0442	prolyl-tRNA aminoacylation
D7I45_RS02940	COG2176	DNA-directed DNA polymerase activity
D7I45_RS02945	COG0779	Required for maturation of 30S ribosomal subunits
D7I45_RS02950	COG0195	Participates in both transcription termination and antitermination
D7I45_RS02955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D7I45_RS02965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D7I45_RS02970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7I45_RS02975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7I45_RS02980	COG0196	riboflavin kinase activity
D7I45_RS02985	COG1420	regulation of RNA biosynthetic process
D7I45_RS02990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7I45_RS03000	COG0484	heat shock protein binding
D7I45_RS03005	COG0481	GTPase activity
D7I45_RS03010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7I45_RS03025	COG2264	protein methyltransferase activity
D7I45_RS03030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D7I45_RS03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7I45_RS03040	COG1490	D-aminoacyl-tRNA deacylase activity
D7I45_RS03050	COG3001	Fructosamine kinase
D7I45_RS03055	COG0124	histidyl-tRNA synthetase
D7I45_RS03060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7I45_RS03065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D7I45_RS03070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7I45_RS03075	COG1682	transport, permease protein
D7I45_RS03080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7I45_RS03085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D7I45_RS03090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D7I45_RS03095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7I45_RS03100	COG1610	YqeY-like protein
D7I45_RS03105	COG1702	phosphate starvation-inducible protein PhoH
D7I45_RS03110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7I45_RS03120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D7I45_RS03125	COG1381	Involved in DNA repair and RecF pathway recombination
D7I45_RS03130	COG0752	glycyl-tRNA synthetase alpha subunit
D7I45_RS03135	COG0751	glycine-tRNA ligase activity
D7I45_RS03140	COG0358	DNA primase activity
D7I45_RS03145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7I45_RS03150	COG2384	SAM-dependent methyltransferase
D7I45_RS03160	COG2195	Cleaves the N-terminal amino acid of tripeptides
D7I45_RS03165	COG0542	response to heat
D7I45_RS03175	COG0587	DNA-directed DNA polymerase activity
D7I45_RS03185	COG2996	Protein conserved in bacteria
D7I45_RS03195	COG0456	acetyltransferase
D7I45_RS03200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D7I45_RS03205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D7I45_RS03210	COG1187	pseudouridine synthase activity
D7I45_RS03215	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D7I45_RS03225	COG0514	ATP-dependent DNA helicase (RecQ)
D7I45_RS03235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D7I45_RS03240	COG0539	negative regulation of cytoplasmic translation
D7I45_RS03245	COG1160	GTP binding
D7I45_RS03270	COG0488	(ABC) transporter
D7I45_RS03275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D7I45_RS03285	COG2755	lipolytic protein G-D-S-L family
D7I45_RS03310	COG0758	DNA mediated transformation
D7I45_RS03315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7I45_RS03330	COG0706	membrane insertase activity
D7I45_RS03335	COG1254	Belongs to the acylphosphatase family
D7I45_RS03340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7I45_RS03350	COG1733	regulation of RNA biosynthetic process
D7I45_RS03355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7I45_RS03360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7I45_RS03360	COG0072	phenylalanine-tRNA ligase activity
D7I45_RS03365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7I45_RS03370	COG0572	uridine kinase
D7I45_RS03375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7I45_RS03385	COG0768	penicillin binding
D7I45_RS03390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7I45_RS03395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7I45_RS03410	COG1940	carbohydrate kinase activity
D7I45_RS03425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D7I45_RS03430	COG0789	Transcriptional regulator
D7I45_RS03450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D7I45_RS03460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D7I45_RS03465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D7I45_RS03470	COG1302	Protein conserved in bacteria
D7I45_RS03475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7I45_RS03480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7I45_RS03485	COG1570	exodeoxyribonuclease VII activity
D7I45_RS03490	COG1722	exodeoxyribonuclease VII activity
D7I45_RS03500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D7I45_RS03505	COG0497	DNA recombination
D7I45_RS03510	COG0194	GDP metabolic process
D7I45_RS03520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D7I45_RS03525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D7I45_RS03530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D7I45_RS03535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7I45_RS03535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7I45_RS03540	COG0631	protein serine/threonine phosphatase activity
D7I45_RS03545	COG0515	serine threonine protein kinase
D7I45_RS03545	COG2815	serine threonine protein kinase
D7I45_RS03550	COG1162	GTPase activity
D7I45_RS03555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D7I45_RS03560	COG1564	THIamine pyrophosphokinase
D7I45_RS03565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7I45_RS03570	COG1302	Protein conserved in bacteria
D7I45_RS03575	COG1461	Dihydroxyacetone kinase
D7I45_RS03580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7I45_RS03585	COG0416	fatty acid biosynthetic process
D7I45_RS03590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7I45_RS03595	COG0571	ribonuclease III activity
D7I45_RS03600	COG1196	nuclear chromosome segregation
D7I45_RS03605	COG0552	protein localization to endoplasmic reticulum
D7I45_RS03610	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D7I45_RS03615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D7I45_RS03635	COG0228	four-way junction DNA binding
D7I45_RS03645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D7I45_RS03650	COG0336	Belongs to the RNA methyltransferase TrmD family
D7I45_RS03655	COG0335	large ribosomal subunit rRNA binding
D7I45_RS03665	COG1942	4-Oxalocrotonate Tautomerase
D7I45_RS03670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7I45_RS03675	COG0561	phosphatase activity
D7I45_RS03680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D7I45_RS03680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7I45_RS03685	COG1304	FMN binding
D7I45_RS03700	COG0083	homoserine kinase activity
D7I45_RS03720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7I45_RS03725	COG3331	DNA recombination
D7I45_RS03730	COG4474	Belongs to the UPF0398 family
D7I45_RS03735	COG3599	regulation of cell shape
D7I45_RS03745	COG0116	Belongs to the methyltransferase superfamily
D7I45_RS03750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7I45_RS03755	COG0328	RNA-DNA hybrid ribonuclease activity
D7I45_RS03765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D7I45_RS03775	COG0564	pseudouridine synthase activity
D7I45_RS03780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D7I45_RS03785	COG0505	Belongs to the CarA family
D7I45_RS03795	COG0386	Belongs to the glutathione peroxidase family
D7I45_RS03800	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D7I45_RS03810	COG1307	EDD domain protein, DegV family
D7I45_RS03815	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D7I45_RS03845	COG1227	inorganic diphosphatase activity
D7I45_RS03850	COG0583	DNA-binding transcription factor activity
D7I45_RS03855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7I45_RS03860	COG0187	DNA topoisomerase II activity
D7I45_RS03865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D7I45_RS03870	COG5002	protein histidine kinase activity
D7I45_RS03875	COG0745	RESPONSE REGULATOR receiver
D7I45_RS03880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D7I45_RS03890	COG1323	Belongs to the UPF0348 family
D7I45_RS03895	COG2226	methyltransferase
D7I45_RS03900	COG0799	negative regulation of ribosome biogenesis
D7I45_RS03905	COG1713	HD superfamily hydrolase involved in NAD metabolism
D7I45_RS03910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7I45_RS03915	COG1534	Rna-binding protein
D7I45_RS03920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D7I45_RS03925	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D7I45_RS03930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7I45_RS03935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D7I45_RS03940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D7I45_RS03945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D7I45_RS03950	COG1484	DNA-dependent DNA replication
D7I45_RS03960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7I45_RS03965	COG0237	dephospho-CoA kinase activity
D7I45_RS03970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7I45_RS03985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7I45_RS03990	COG1674	ftsk spoiiie
D7I45_RS03995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7I45_RS04000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7I45_RS04010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D7I45_RS04020	COG1131	(ABC) transporter
D7I45_RS04025	COG0537	adenosine 5'-monophosphoramidase activity
D7I45_RS04035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7I45_RS04040	COG4717	serine-type aminopeptidase activity
D7I45_RS04045	COG0420	3'-5' exonuclease activity
D7I45_RS04050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7I45_RS04055	COG0018	arginyl-trna synthetase
D7I45_RS04075	COG1794	racemase activity, acting on amino acids and derivatives
D7I45_RS04090	COG0367	asparagine synthase
D7I45_RS04095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7I45_RS04105	COG1970	mechanosensitive ion channel activity
D7I45_RS04110	COG1428	Deoxynucleoside kinase
D7I45_RS04115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7I45_RS04120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D7I45_RS04125	COG2244	polysaccharide biosynthetic process
D7I45_RS04130	COG0495	leucyl-tRNA aminoacylation
D7I45_RS04135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D7I45_RS04140	COG0477	Major facilitator Superfamily
D7I45_RS04145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D7I45_RS04230	COG0586	Pfam SNARE associated Golgi protein
D7I45_RS04240	COG0647	UMP catabolic process
D7I45_RS04245	COG4470	Protein conserved in bacteria
D7I45_RS04250	COG0737	Belongs to the 5'-nucleotidase family
D7I45_RS04260	COG1113	amino acid transport
D7I45_RS04270	COG0827	DNA restriction-modification system
D7I45_RS04285	COG4537	Required for transformation and DNA binding
D7I45_RS04295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7I45_RS04300	COG0217	transcriptional regulatory protein
D7I45_RS04305	COG1609	Transcriptional regulator
D7I45_RS04320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7I45_RS04325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D7I45_RS04330	COG1719	4-vinyl reductase, 4VR
D7I45_RS04335	COG3118	belongs to the thioredoxin family
D7I45_RS04340	COG3118	belongs to the thioredoxin family
D7I45_RS04345	COG1193	negative regulation of DNA recombination
D7I45_RS04360	COG3906	Belongs to the UPF0473 family
D7I45_RS04365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D7I45_RS04370	COG4472	Bacterial protein of unknown function (DUF965)
D7I45_RS04375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7I45_RS04380	COG0513	Belongs to the DEAD box helicase family
D7I45_RS04385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7I45_RS04390	COG1862	Preprotein translocase
D7I45_RS04395	COG2255	four-way junction helicase activity
D7I45_RS04405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D7I45_RS04410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D7I45_RS04415	COG1692	metallophosphoesterase
D7I45_RS04425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7I45_RS04430	COG1058	Belongs to the CinA family
D7I45_RS04430	COG1546	Belongs to the CinA family
D7I45_RS04435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7I45_RS04440	COG1426	Protein conserved in bacteria
D7I45_RS04445	COG0612	Peptidase, M16
D7I45_RS04450	COG0612	Peptidase, M16
D7I45_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7I45_RS04460	COG1126	abc transporter atp-binding protein
D7I45_RS04465	COG0765	amino acid transport
D7I45_RS04470	COG2894	cell division
D7I45_RS04475	COG0850	regulation of cytokinetic process
D7I45_RS04490	COG1077	Cell shape determining protein MreB Mrl
D7I45_RS04495	COG0285	dihydrofolate synthase activity
D7I45_RS04500	COG0525	valine-tRNA ligase activity
D7I45_RS04510	COG0301	tRNA thio-modification
D7I45_RS04515	COG1104	cysteine desulfurase activity
D7I45_RS04520	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D7I45_RS04525	COG1956	GAF domain-containing protein
D7I45_RS04530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7I45_RS04540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7I45_RS04550	COG0589	response to stress
D7I45_RS04560	COG2818	Glycosylase
D7I45_RS04565	COG1181	Belongs to the D-alanine--D-alanine ligase family
D7I45_RS04575	COG1131	(ABC) transporter
D7I45_RS04585	COG1464	Belongs to the NlpA lipoprotein family
D7I45_RS04590	COG2011	ABC-type metal ion transport system permease component
D7I45_RS04595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7I45_RS04600	COG0772	Belongs to the SEDS family
D7I45_RS04610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D7I45_RS04615	COG1077	Cell shape determining protein MreB Mrl
D7I45_RS04620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7I45_RS04630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D7I45_RS04635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D7I45_RS04640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7I45_RS04650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7I45_RS04655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D7I45_RS04660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7I45_RS04665	COG0356	it plays a direct role in the translocation of protons across the membrane
D7I45_RS04670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7I45_RS04675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7I45_RS04680	COG0009	L-threonylcarbamoyladenylate synthase
D7I45_RS04685	COG2890	protein-(glutamine-N5) methyltransferase activity
D7I45_RS04695	COG1435	thymidine kinase activity
D7I45_RS04700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7I45_RS04705	COG3442	glutamine amidotransferase
D7I45_RS04715	COG1132	(ABC) transporter
D7I45_RS04730	COG1335	isochorismatase
D7I45_RS04765	COG1063	alcohol dehydrogenase
D7I45_RS04770	COG0017	Asparaginyl-tRNA synthetase
D7I45_RS04785	COG4975	Glucose uptake
D7I45_RS04795	COG0477	Major facilitator Superfamily
D7I45_RS04805	COG3158	transport of potassium into the cell
D7I45_RS04810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7I45_RS04825	COG1134	teichoic acid transport
D7I45_RS04830	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7I45_RS04830	COG1388	LysM domain
D7I45_RS04835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7I45_RS04840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7I45_RS04860	COG0025	NhaP-type Na H and K H
D7I45_RS04865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7I45_RS04870	COG2176	DNA-directed DNA polymerase activity
D7I45_RS04880	COG0802	atpase or kinase
D7I45_RS04885	COG0280	phosphate acetyltransferase
D7I45_RS04890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D7I45_RS04895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D7I45_RS04900	COG0557	exoribonuclease II activity
D7I45_RS04905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7I45_RS04910	COG0038	chloride channel
D7I45_RS04915	COG0148	phosphopyruvate hydratase activity
D7I45_RS04920	COG0149	triose-phosphate isomerase activity
D7I45_RS04940	COG0740	serine-type endopeptidase activity
D7I45_RS04945	COG1481	regulation of sporulation
D7I45_RS04950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D7I45_RS04955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7I45_RS04960	COG0556	nucleotide-excision repair
D7I45_RS04965	COG0492	ferredoxin-NADP+ reductase activity
D7I45_RS04970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7I45_RS04975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7I45_RS04980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D7I45_RS04985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D7I45_RS04990	COG1950	PFAM Membrane protein of
D7I45_RS05000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7I45_RS05010	COG0653	protein targeting
D7I45_RS05015	COG1040	competence protein
D7I45_RS05020	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D7I45_RS05025	COG1739	Uncharacterized protein family UPF0029
D7I45_RS05030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7I45_RS05035	COG0459	protein refolding
D7I45_RS05040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7I45_RS05045	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D7I45_RS05050	COG0488	(ABC) transporter
D7I45_RS05055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7I45_RS05065	COG1214	PFAM Peptidase M22, glycoprotease
D7I45_RS05075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D7I45_RS05080	COG4467	Involved in initiation control of chromosome replication
D7I45_RS05085	COG0470	DNA polymerase III
D7I45_RS05090	COG3870	Protein conserved in bacteria
D7I45_RS05095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7I45_RS05115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7I45_RS05130	COG2813	Specifically methylates the guanine in position
D7I45_RS05135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7I45_RS05140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7I45_RS05145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7I45_RS05150	COG0392	lysyltransferase activity
D7I45_RS05150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D7I45_RS05155	COG0222	ribosome binding
D7I45_RS05160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7I45_RS05165	COG0081	regulation of translation
D7I45_RS05170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D7I45_RS05175	COG0250	Participates in transcription elongation, termination and antitermination
D7I45_RS05185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7I45_RS05195	COG3688	RNA-binding protein containing a PIN domain
D7I45_RS05200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7I45_RS05210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7I45_RS05215	COG4956	integral membrane protein (PIN domain superfamily)
D7I45_RS05220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D7I45_RS05225	COG0756	dUTP diphosphatase activity
D7I45_RS05230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D7I45_RS05240	COG0588	phosphoglycerate mutase activity
D7I45_RS05245	COG0697	spore germination
D7I45_RS05250	COG1316	TRANSCRIPTIONal
D7I45_RS05270	COG0083	homoserine kinase activity
D7I45_RS05275	COG3091	SprT-like family
D7I45_RS05280	COG2183	response to ionizing radiation
D7I45_RS05300	COG2188	Transcriptional regulator
D7I45_RS05305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7I45_RS05320	COG3104	oligopeptide transport
D7I45_RS05360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7I45_RS05365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7I45_RS05370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D7I45_RS05385	COG0037	tRNA processing
D7I45_RS05390	COG1098	S1 RNA binding domain
D7I45_RS05400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D7I45_RS05405	COG2244	polysaccharide biosynthetic process
D7I45_RS05410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7I45_RS05415	COG0193	aminoacyl-tRNA hydrolase activity
D7I45_RS05420	COG0039	L-malate dehydrogenase activity
D7I45_RS05430	COG2337	Toxic component of a toxin-antitoxin (TA) module
D7I45_RS05440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D7I45_RS05450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7I45_RS05465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7I45_RS05470	COG0504	CTP synthase activity
D7I45_RS05475	COG3343	RNA polymerase activity
D7I45_RS05485	COG1078	dGTPase activity
D7I45_RS05500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7I45_RS05505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7I45_RS05510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7I45_RS05515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7I45_RS05520	COG4466	Protein conserved in bacteria
D7I45_RS05530	COG0084	hydrolase, TatD family'
D7I45_RS05535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7I45_RS05535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7I45_RS05540	COG1801	Protein of unknown function DUF72
D7I45_RS05545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7I45_RS05560	COG0248	Ppx GppA phosphatase
D7I45_RS05570	COG3973	AAA domain
D7I45_RS05595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7I45_RS05605	COG2814	Major facilitator Superfamily
D7I45_RS05615	COG1215	transferase activity, transferring glycosyl groups
D7I45_RS05630	COG0588	phosphoglycerate mutase activity
D7I45_RS05635	COG0628	permease
D7I45_RS05640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7I45_RS05655	COG3583	domain protein
D7I45_RS05655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7I45_RS05655	COG3064	Membrane
D7I45_RS05660	COG1686	Belongs to the peptidase S11 family
D7I45_RS05670	COG0745	RESPONSE REGULATOR receiver
D7I45_RS05675	COG0516	GMP reductase activity
D7I45_RS05675	COG0517	IMP dehydrogenase activity
D7I45_RS05685	COG0012	GTP binding
D7I45_RS05690	COG4481	Protein conserved in bacteria
D7I45_RS05695	COG1475	DNA binding
D7I45_RS05700	COG1192	Involved in chromosome partitioning
D7I45_RS05705	COG0357	Ribosomal RNA small subunit methyltransferase G
D7I45_RS05715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D7I45_RS05720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D7I45_RS05740	COG0583	DNA-binding transcription factor activity
D7I45_RS05760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7I45_RS05825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7I45_RS05830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D7I45_RS05835	COG3764	Sortase (surface protein transpeptidase)
D7I45_RS05840	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7I45_RS05840	COG1388	LysM domain
D7I45_RS05850	COG1757	Na H antiporter
D7I45_RS05855	COG3118	belongs to the thioredoxin family
D7I45_RS05860	COG0861	Integral membrane protein TerC family
D7I45_RS05865	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7I45_RS05880	COG0406	alpha-ribazole phosphatase activity
D7I45_RS05890	COG1368	sulfuric ester hydrolase activity
D7I45_RS05895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7I45_RS05900	COG0492	ferredoxin-NADP+ reductase activity
D7I45_RS05910	COG0516	GMP reductase activity
D7I45_RS05920	COG0561	phosphatase activity
D7I45_RS05925	COG1393	Belongs to the ArsC family
D7I45_RS05930	COG0737	Belongs to the 5'-nucleotidase family
D7I45_RS05935	COG1418	mRNA catabolic process
D7I45_RS05950	COG0004	ammonium transporteR
D7I45_RS05970	COG0564	pseudouridine synthase activity
D7I45_RS05975	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D7I45_RS05980	COG2188	Transcriptional regulator
D7I45_RS05985	COG0640	Transcriptional regulator
D7I45_RS05995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7I45_RS06000	COG1418	mRNA catabolic process
D7I45_RS06015	COG0656	L-ascorbic acid biosynthetic process
D7I45_RS06025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7I45_RS06035	COG1268	BioY protein
D7I45_RS06045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7I45_RS06055	COG0789	Transcriptional regulator
D7I45_RS06085	COG0656	L-ascorbic acid biosynthetic process
D7I45_RS06090	COG0531	amino acid
D7I45_RS06105	COG1063	alcohol dehydrogenase
D7I45_RS06120	COG1940	carbohydrate kinase activity
D7I45_RS06125	COG0166	Belongs to the GPI family
D7I45_RS06130	COG1940	carbohydrate kinase activity