locus-tag	class	description
C5Z25_RS00105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5Z25_RS00115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5Z25_RS00120	COG0006	proline dipeptidase activity
C5Z25_RS00125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5Z25_RS00130	COG1302	Protein conserved in bacteria
C5Z25_RS00135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5Z25_RS00140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5Z25_RS00145	COG1570	exodeoxyribonuclease VII activity
C5Z25_RS00150	COG1722	exodeoxyribonuclease VII activity
C5Z25_RS00155	COG0142	geranyltranstransferase activity
C5Z25_RS00160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C5Z25_RS00165	COG1438	arginine binding
C5Z25_RS00170	COG0497	DNA recombination
C5Z25_RS00190	COG1174	glycine betaine transport
C5Z25_RS00200	COG0194	GDP metabolic process
C5Z25_RS00205	COG1758	RNA polymerase activity
C5Z25_RS00210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5Z25_RS00215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5Z25_RS00220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5Z25_RS00225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5Z25_RS00225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5Z25_RS00230	COG0631	protein serine/threonine phosphatase activity
C5Z25_RS00235	COG2815	serine threonine protein kinase
C5Z25_RS00235	COG0515	serine threonine protein kinase
C5Z25_RS00240	COG1162	GTPase activity
C5Z25_RS00245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5Z25_RS00260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5Z25_RS00265	COG1302	Protein conserved in bacteria
C5Z25_RS00270	COG1461	Dihydroxyacetone kinase
C5Z25_RS00275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5Z25_RS00280	COG0416	fatty acid biosynthetic process
C5Z25_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5Z25_RS00290	COG0571	ribonuclease III activity
C5Z25_RS00295	COG1196	nuclear chromosome segregation
C5Z25_RS00300	COG0552	protein localization to endoplasmic reticulum
C5Z25_RS00305	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C5Z25_RS00310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5Z25_RS00315	COG0228	four-way junction DNA binding
C5Z25_RS00320	COG1837	Belongs to the UPF0109 family
C5Z25_RS00325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5Z25_RS00330	COG0336	Belongs to the RNA methyltransferase TrmD family
C5Z25_RS00335	COG0335	large ribosomal subunit rRNA binding
C5Z25_RS00345	COG0477	Major facilitator Superfamily
C5Z25_RS00370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5Z25_RS00375	COG1942	4-Oxalocrotonate Tautomerase
C5Z25_RS00380	COG0019	diaminopimelate decarboxylase activity
C5Z25_RS00385	COG1942	4-Oxalocrotonate Tautomerase
C5Z25_RS00400	COG0561	phosphatase activity
C5Z25_RS00405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C5Z25_RS00405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5Z25_RS00410	COG1304	FMN binding
C5Z25_RS00430	COG1199	ATP-dependent helicase activity
C5Z25_RS00430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5Z25_RS00445	COG0017	Asparaginyl-tRNA synthetase
C5Z25_RS00460	COG3331	DNA recombination
C5Z25_RS00465	COG4474	Belongs to the UPF0398 family
C5Z25_RS00470	COG3599	regulation of cell shape
C5Z25_RS00480	COG0116	Belongs to the methyltransferase superfamily
C5Z25_RS00505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5Z25_RS00510	COG1073	alpha beta
C5Z25_RS00550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5Z25_RS00565	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C5Z25_RS00570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5Z25_RS00575	COG0564	pseudouridine synthase activity
C5Z25_RS00580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5Z25_RS00585	COG0505	Belongs to the CarA family
C5Z25_RS00590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5Z25_RS00610	COG0463	Glycosyl transferase, family 2
C5Z25_RS00630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5Z25_RS00635	COG1263	PTS System
C5Z25_RS00635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS00640	COG1737	Transcriptional regulator
C5Z25_RS00645	COG2190	(PTS) system
C5Z25_RS00645	COG1263	PTS System
C5Z25_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS00655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C5Z25_RS00665	COG1307	EDD domain protein, DegV family
C5Z25_RS00715	COG1113	amino acid transport
C5Z25_RS00725	COG1620	l-lactate permease
C5Z25_RS00740	COG1846	Transcriptional regulator
C5Z25_RS00745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5Z25_RS00805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5Z25_RS00815	COG1227	inorganic diphosphatase activity
C5Z25_RS00820	COG0583	DNA-binding transcription factor activity
C5Z25_RS00830	COG0187	DNA topoisomerase II activity
C5Z25_RS00835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5Z25_RS00845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5Z25_RS00850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5Z25_RS00855	COG4974	Belongs to the 'phage' integrase family
C5Z25_RS00860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C5Z25_RS00865	COG1070	Carbohydrate kinase
C5Z25_RS00870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5Z25_RS00875	COG0758	DNA mediated transformation
C5Z25_RS00880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5Z25_RS00885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5Z25_RS00890	COG3409	Peptidoglycan-binding domain 1 protein
C5Z25_RS00890	COG0793	Belongs to the peptidase S41A family
C5Z25_RS00895	COG4479	Belongs to the UPF0346 family
C5Z25_RS00900	COG4698	Protein conserved in bacteria
C5Z25_RS00905	COG2755	lipolytic protein G-D-S-L family
C5Z25_RS00910	COG1307	EDD domain protein, DegV family
C5Z25_RS00915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5Z25_RS00920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5Z25_RS00925	COG0488	(ABC) transporter
C5Z25_RS00935	COG0617	tRNA 3'-terminal CCA addition
C5Z25_RS00940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5Z25_RS00945	COG0561	phosphatase activity
C5Z25_RS00950	COG0457	Tetratricopeptide repeat
C5Z25_RS00965	COG1160	GTP binding
C5Z25_RS00970	COG0539	negative regulation of cytoplasmic translation
C5Z25_RS00975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5Z25_RS00985	COG0514	ATP-dependent DNA helicase (RecQ)
C5Z25_RS00995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C5Z25_RS01000	COG1187	pseudouridine synthase activity
C5Z25_RS01005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5Z25_RS01010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5Z25_RS01020	COG4974	Belongs to the 'phage' integrase family
C5Z25_RS01025	COG2996	Protein conserved in bacteria
C5Z25_RS01040	COG0205	6-phosphofructokinase activity
C5Z25_RS01055	COG0542	response to heat
C5Z25_RS01060	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5Z25_RS01065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5Z25_RS01070	COG2384	SAM-dependent methyltransferase
C5Z25_RS01080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5Z25_RS01085	COG0358	DNA primase activity
C5Z25_RS01090	COG0751	glycine-tRNA ligase activity
C5Z25_RS01095	COG0752	glycyl-tRNA synthetase alpha subunit
C5Z25_RS01100	COG1381	Involved in DNA repair and RecF pathway recombination
C5Z25_RS01105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5Z25_RS01110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C5Z25_RS01115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5Z25_RS01120	COG1702	phosphate starvation-inducible protein PhoH
C5Z25_RS01125	COG1610	YqeY-like protein
C5Z25_RS01130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5Z25_RS01135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C5Z25_RS01140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5Z25_RS01145	COG1682	transport, permease protein
C5Z25_RS01155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5Z25_RS01165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5Z25_RS01170	COG0124	histidyl-tRNA synthetase
C5Z25_RS01175	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5Z25_RS01180	COG0546	phosphoglycolate phosphatase activity
C5Z25_RS01185	COG1490	D-aminoacyl-tRNA deacylase activity
C5Z25_RS01190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5Z25_RS01200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5Z25_RS01205	COG2264	protein methyltransferase activity
C5Z25_RS01210	COG2094	Belongs to the DNA glycosylase MPG family
C5Z25_RS01240	COG0481	GTPase activity
C5Z25_RS01250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C5Z25_RS01255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5Z25_RS01260	COG1696	Membrane protein involved in D-alanine export
C5Z25_RS01265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5Z25_RS01275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5Z25_RS01280	COG0484	heat shock protein binding
C5Z25_RS01285	COG0443	Heat shock 70 kDa protein
C5Z25_RS01290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5Z25_RS01295	COG1420	regulation of RNA biosynthetic process
C5Z25_RS01300	COG3527	Alpha-acetolactate decarboxylase
C5Z25_RS01305	COG0196	riboflavin kinase activity
C5Z25_RS01310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5Z25_RS01315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5Z25_RS01320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5Z25_RS01330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C5Z25_RS01340	COG0779	Required for maturation of 30S ribosomal subunits
C5Z25_RS01345	COG2176	DNA-directed DNA polymerase activity
C5Z25_RS01350	COG0442	prolyl-tRNA aminoacylation
C5Z25_RS01355	COG0750	zinc metalloprotease
C5Z25_RS01360	COG4589	Belongs to the CDS family
C5Z25_RS01365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5Z25_RS01370	COG0233	cytoplasmic translational termination
C5Z25_RS01375	COG0528	UMP kinase activity
C5Z25_RS01380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5Z25_RS01385	COG0052	Belongs to the universal ribosomal protein uS2 family
C5Z25_RS01395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5Z25_RS01400	COG2827	Endonuclease containing a URI domain
C5Z25_RS01405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C5Z25_RS01410	COG0204	Acyl-transferase
C5Z25_RS01420	COG4224	UPF0291 protein
C5Z25_RS01425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5Z25_RS01455	COG0110	maltose O-acetyltransferase activity
C5Z25_RS01475	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5Z25_RS01605	COG5484	DNA packaging
C5Z25_RS01640	COG1484	DNA-dependent DNA replication
C5Z25_RS01655	COG0629	single-stranded DNA binding
C5Z25_RS01760	COG0028	Belongs to the TPP enzyme family
C5Z25_RS01765	COG1959	2 iron, 2 sulfur cluster binding
C5Z25_RS01780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5Z25_RS01785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5Z25_RS01785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5Z25_RS01790	COG5416	Lipopolysaccharide assembly protein A domain
C5Z25_RS01795	COG0300	oxidoreductase activity
C5Z25_RS01800	COG1234	tRNA 3'-trailer cleavage
C5Z25_RS01810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5Z25_RS01815	COG1349	DNA-binding transcription factor activity
C5Z25_RS01820	COG1105	Belongs to the carbohydrate kinase PfkB family
C5Z25_RS01825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5Z25_RS01825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5Z25_RS01825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5Z25_RS01830	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5Z25_RS01835	COG0322	excinuclease ABC activity
C5Z25_RS01840	COG1126	abc transporter atp-binding protein
C5Z25_RS01845	COG0765	amino acid transport
C5Z25_RS01850	COG0789	Transcriptional regulator
C5Z25_RS01870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5Z25_RS01875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5Z25_RS01880	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5Z25_RS01885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5Z25_RS01905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5Z25_RS01910	COG0268	Binds directly to 16S ribosomal RNA
C5Z25_RS01915	COG1466	dna polymerase III delta subunit
C5Z25_RS01920	COG0658	competence protein
C5Z25_RS01920	COG2333	competence protein COMEC
C5Z25_RS01925	COG2131	deaminase
C5Z25_RS01930	COG1596	polysaccharide export
C5Z25_RS01930	COG1555	photosystem II stabilization
C5Z25_RS01935	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5Z25_RS01940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5Z25_RS01945	COG0742	ribosomal rna small subunit methyltransferase
C5Z25_RS01950	COG4471	UPF0298 protein
C5Z25_RS01955	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5Z25_RS01960	COG0772	Belongs to the SEDS family
C5Z25_RS01965	COG1217	gtp-binding protein TYPA
C5Z25_RS01970	COG0483	inositol monophosphate 1-phosphatase activity
C5Z25_RS01975	COG4476	Belongs to the UPF0223 family
C5Z25_RS01980	COG0039	L-malate dehydrogenase activity
C5Z25_RS02005	COG0242	peptide deformylase activity
C5Z25_RS02015	COG5503	Protein of unknown function (DUF1447)
C5Z25_RS02020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5Z25_RS02025	COG1597	lipid kinase activity
C5Z25_RS02035	COG1388	LysM domain
C5Z25_RS02035	COG1388	LysM domain
C5Z25_RS02035	COG0791	NLP P60 protein
C5Z25_RS02035	COG0791	NLP P60 protein
C5Z25_RS02045	COG4975	Glucose uptake
C5Z25_RS02050	COG1869	D-ribose catabolic process
C5Z25_RS02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5Z25_RS02070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5Z25_RS02085	COG0569	domain protein
C5Z25_RS02090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5Z25_RS02095	COG0482	sulfurtransferase activity
C5Z25_RS02105	COG1104	cysteine desulfurase activity
C5Z25_RS02110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5Z25_RS02120	COG0494	nUDIX hydrolase
C5Z25_RS02125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5Z25_RS02130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5Z25_RS02135	COG3599	regulation of cell shape
C5Z25_RS02145	COG0762	integral membrane protein
C5Z25_RS02150	COG1799	cell septum assembly
C5Z25_RS02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5Z25_RS02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5Z25_RS02170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5Z25_RS02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5Z25_RS02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Z25_RS02185	COG0768	penicillin binding
C5Z25_RS02195	COG0275	rRNA processing
C5Z25_RS02200	COG2001	Belongs to the MraZ family
C5Z25_RS02225	COG3732	PTS system glucitol sorbitol-specific
C5Z25_RS02230	COG3730	PTS system glucitol sorbitol-specific
C5Z25_RS02250	COG1674	ftsk spoiiie
C5Z25_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5Z25_RS02265	COG2910	NAD(P)H-binding
C5Z25_RS02270	COG1114	Component of the transport system for branched-chain amino acids
C5Z25_RS02280	COG0500	methyltransferase
C5Z25_RS02285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5Z25_RS02295	COG0628	permease
C5Z25_RS02305	COG2706	6-phosphogluconolactonase activity
C5Z25_RS02310	COG3142	Participates in the control of copper homeostasis
C5Z25_RS02315	COG0564	pseudouridine synthase activity
C5Z25_RS02320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5Z25_RS02325	COG2357	RelA SpoT domain protein
C5Z25_RS02345	COG4862	establishment of competence for transformation
C5Z25_RS02350	COG1393	Belongs to the ArsC family
C5Z25_RS02355	COG1234	tRNA 3'-trailer cleavage
C5Z25_RS02495	COG1098	S1 RNA binding domain
C5Z25_RS02505	COG0586	Pfam SNARE associated Golgi protein
C5Z25_RS02515	COG0647	UMP catabolic process
C5Z25_RS02520	COG4470	Protein conserved in bacteria
C5Z25_RS02525	COG0737	Belongs to the 5'-nucleotidase family
C5Z25_RS02535	COG1113	amino acid transport
C5Z25_RS02540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5Z25_RS02545	COG0827	DNA restriction-modification system
C5Z25_RS02570	COG4537	Required for transformation and DNA binding
C5Z25_RS02580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5Z25_RS02590	COG0217	transcriptional regulatory protein
C5Z25_RS02605	COG1609	Transcriptional regulator
C5Z25_RS02610	COG0006	proline dipeptidase activity
C5Z25_RS02615	COG0656	L-ascorbic acid biosynthetic process
C5Z25_RS02630	COG0668	transmembrane transport
C5Z25_RS02635	COG1473	amidohydrolase
C5Z25_RS02640	COG2171	N-acyltransferase activity
C5Z25_RS02655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5Z25_RS02660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5Z25_RS02670	COG3118	belongs to the thioredoxin family
C5Z25_RS02675	COG1193	negative regulation of DNA recombination
C5Z25_RS02710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5Z25_RS02710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5Z25_RS02715	COG3475	LICD family
C5Z25_RS02720	COG1442	glycosyl transferase family 8
C5Z25_RS02720	COG1216	Glycosyl transferase, family 2
C5Z25_RS02735	COG1216	Glycosyl transferase, family 2
C5Z25_RS02735	COG1442	glycosyl transferase family 8
C5Z25_RS02745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5Z25_RS02750	COG4464	protein tyrosine phosphatase activity
C5Z25_RS02755	COG0489	protein tyrosine kinase activity
C5Z25_RS02765	COG0582	viral genome integration into host DNA
C5Z25_RS02770	COG3906	Belongs to the UPF0473 family
C5Z25_RS02775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5Z25_RS02780	COG4472	Bacterial protein of unknown function (DUF965)
C5Z25_RS02785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5Z25_RS02795	COG0513	Belongs to the DEAD box helicase family
C5Z25_RS02800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5Z25_RS02805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5Z25_RS02815	COG1862	Preprotein translocase
C5Z25_RS02820	COG0343	queuine tRNA-ribosyltransferase activity
C5Z25_RS02825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5Z25_RS02830	COG2255	four-way junction helicase activity
C5Z25_RS02835	COG0632	four-way junction helicase activity
C5Z25_RS02850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5Z25_RS02855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5Z25_RS02860	COG1692	metallophosphoesterase
C5Z25_RS02865	COG1418	mRNA catabolic process
C5Z25_RS02870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5Z25_RS02875	COG1546	Belongs to the CinA family
C5Z25_RS02875	COG1058	Belongs to the CinA family
C5Z25_RS02880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5Z25_RS02885	COG1426	Protein conserved in bacteria
C5Z25_RS02890	COG0612	Peptidase, M16
C5Z25_RS02895	COG0612	Peptidase, M16
C5Z25_RS02900	COG0527	aspartate kinase activity
C5Z25_RS02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Z25_RS02910	COG1126	abc transporter atp-binding protein
C5Z25_RS02915	COG0765	amino acid transport
C5Z25_RS02920	COG2894	cell division
C5Z25_RS02925	COG0850	regulation of cytokinetic process
C5Z25_RS02935	COG1792	Involved in formation and maintenance of cell shape
C5Z25_RS02940	COG1077	Cell shape determining protein MreB Mrl
C5Z25_RS02945	COG2003	Belongs to the UPF0758 family
C5Z25_RS02950	COG0285	dihydrofolate synthase activity
C5Z25_RS02955	COG0525	valine-tRNA ligase activity
C5Z25_RS02965	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5Z25_RS02965	COG2918	glutathione biosynthetic process
C5Z25_RS02975	COG0301	tRNA thio-modification
C5Z25_RS02980	COG1104	cysteine desulfurase activity
C5Z25_RS02985	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C5Z25_RS02990	COG1956	GAF domain-containing protein
C5Z25_RS02995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5Z25_RS03000	COG4493	Belongs to the UPF0637 family
C5Z25_RS03010	COG0189	ligase activity
C5Z25_RS03010	COG2918	glutathione biosynthetic process
C5Z25_RS03015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5Z25_RS03025	COG0589	response to stress
C5Z25_RS03055	COG1396	sequence-specific DNA binding
C5Z25_RS03070	COG0025	NhaP-type Na H and K H
C5Z25_RS03075	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5Z25_RS03095	COG1464	Belongs to the NlpA lipoprotein family
C5Z25_RS03100	COG2011	ABC-type metal ion transport system permease component
C5Z25_RS03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5Z25_RS03110	COG0509	glycine decarboxylation via glycine cleavage system
C5Z25_RS03115	COG0772	Belongs to the SEDS family
C5Z25_RS03125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5Z25_RS03130	COG1077	Cell shape determining protein MreB Mrl
C5Z25_RS03140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5Z25_RS03145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5Z25_RS03150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5Z25_RS03155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5Z25_RS03160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5Z25_RS03165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5Z25_RS03170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5Z25_RS03175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5Z25_RS03180	COG0356	it plays a direct role in the translocation of protons across the membrane
C5Z25_RS03185	COG2233	PERMEase
C5Z25_RS03190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5Z25_RS03195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5Z25_RS03200	COG0009	L-threonylcarbamoyladenylate synthase
C5Z25_RS03205	COG2890	protein-(glutamine-N5) methyltransferase activity
C5Z25_RS03210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5Z25_RS03215	COG1435	thymidine kinase activity
C5Z25_RS03220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5Z25_RS03225	COG3442	glutamine amidotransferase
C5Z25_RS03230	COG1482	cell wall glycoprotein biosynthetic process
C5Z25_RS03235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5Z25_RS03240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5Z25_RS03255	COG1132	(ABC) transporter
C5Z25_RS03300	COG0166	Belongs to the GPI family
C5Z25_RS03305	COG4975	Glucose uptake
C5Z25_RS03315	COG5002	protein histidine kinase activity
C5Z25_RS03315	COG3850	Histidine kinase
C5Z25_RS03320	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS03360	COG0477	Major facilitator Superfamily
C5Z25_RS03385	COG1522	sequence-specific DNA binding
C5Z25_RS03395	COG0488	(ABC) transporter
C5Z25_RS03415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS03415	COG2190	(PTS) system
C5Z25_RS03415	COG1263	PTS System
C5Z25_RS03420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5Z25_RS03425	COG1307	EDD domain protein, DegV family
C5Z25_RS03430	COG0460	homoserine dehydrogenase
C5Z25_RS03435	COG2873	o-acetylhomoserine
C5Z25_RS03440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C5Z25_RS03455	COG4120	Belongs to the binding-protein-dependent transport system permease family
C5Z25_RS03465	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Z25_RS03470	COG2084	Dehydrogenase
C5Z25_RS03475	COG0861	Integral membrane protein TerC family
C5Z25_RS03480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5Z25_RS03485	COG0140	phosphoribosyl-ATP diphosphatase activity
C5Z25_RS03490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5Z25_RS03495	COG0107	imidazoleglycerol-phosphate synthase activity
C5Z25_RS03500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5Z25_RS03505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5Z25_RS03510	COG0131	Imidazoleglycerol-phosphate dehydratase
C5Z25_RS03515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5Z25_RS03520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5Z25_RS03525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C5Z25_RS03530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5Z25_RS03550	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C5Z25_RS03555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5Z25_RS03560	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C5Z25_RS03585	COG1368	sulfuric ester hydrolase activity
C5Z25_RS03595	COG0431	NADPH-dependent FMN reductase
C5Z25_RS03595	COG1053	succinate dehydrogenase
C5Z25_RS03595	COG3976	FMN-binding domain protein
C5Z25_RS03600	COG3976	FMN-binding domain protein
C5Z25_RS03600	COG1053	succinate dehydrogenase
C5Z25_RS03600	COG0431	NADPH-dependent FMN reductase
C5Z25_RS03605	COG0583	DNA-binding transcription factor activity
C5Z25_RS03615	COG0492	ferredoxin-NADP+ reductase activity
C5Z25_RS03625	COG1120	ATPase activity
C5Z25_RS03640	COG2326	polyphosphate kinase activity
C5Z25_RS03670	COG1131	(ABC) transporter
C5Z25_RS03680	COG0561	phosphatase activity
C5Z25_RS03685	COG1609	Transcriptional regulator
C5Z25_RS03690	COG1737	Transcriptional regulator
C5Z25_RS03700	COG0673	inositol 2-dehydrogenase activity
C5Z25_RS03705	COG0673	inositol 2-dehydrogenase activity
C5Z25_RS03715	COG1335	isochorismatase
C5Z25_RS03725	COG1131	(ABC) transporter
C5Z25_RS03730	COG2188	Transcriptional regulator
C5Z25_RS03740	COG4975	Glucose uptake
C5Z25_RS03765	COG1073	alpha beta
C5Z25_RS03770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5Z25_RS03775	COG0626	cystathionine gamma-synthase activity
C5Z25_RS03835	COG0095	Lipoate-protein ligase
C5Z25_RS03840	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5Z25_RS03845	COG0589	response to stress
C5Z25_RS03850	COG0564	pseudouridine synthase activity
C5Z25_RS03855	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5Z25_RS03860	COG2188	Transcriptional regulator
C5Z25_RS03865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5Z25_RS03875	COG1418	mRNA catabolic process
C5Z25_RS03905	COG0071	Belongs to the small heat shock protein (HSP20) family
C5Z25_RS03915	COG1253	flavin adenine dinucleotide binding
C5Z25_RS03920	COG3279	Response regulator of the LytR AlgR family
C5Z25_RS03940	COG1780	Probably involved in ribonucleotide reductase function
C5Z25_RS03945	COG2814	Major facilitator Superfamily
C5Z25_RS03950	COG0114	fumarate hydratase activity
C5Z25_RS03960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C5Z25_RS03970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5Z25_RS03975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5Z25_RS03985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5Z25_RS03990	COG0702	epimerase
C5Z25_RS04000	COG1074	ATP-dependent DNA helicase activity
C5Z25_RS04005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C5Z25_RS04010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5Z25_RS04015	COG0284	orotidine-5'-phosphate decarboxylase activity
C5Z25_RS04020	COG0167	dihydroorotate dehydrogenase activity
C5Z25_RS04025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5Z25_RS04030	COG0505	Belongs to the CarA family
C5Z25_RS04035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5Z25_RS04040	COG0540	Belongs to the ATCase OTCase family
C5Z25_RS04045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5Z25_RS04065	COG2252	PERMEase
C5Z25_RS04070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5Z25_RS04075	COG0151	Belongs to the GarS family
C5Z25_RS04080	COG0138	bifunctional purine biosynthesis protein purh
C5Z25_RS04085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5Z25_RS04090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5Z25_RS04100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5Z25_RS04105	COG0047	phosphoribosylformylglycinamidine synthase activity
C5Z25_RS04110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5Z25_RS04115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5Z25_RS04120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5Z25_RS04125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5Z25_RS04140	COG2365	Tyrosine phosphatase family
C5Z25_RS04160	COG1136	(ABC) transporter
C5Z25_RS04175	COG1725	Transcriptional regulator
C5Z25_RS04180	COG1131	(ABC) transporter
C5Z25_RS04200	COG0589	response to stress
C5Z25_RS04210	COG2246	polysaccharide biosynthetic process
C5Z25_RS04225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5Z25_RS04245	COG0366	Alpha amylase catalytic
C5Z25_RS04255	COG0561	phosphatase activity
C5Z25_RS04285	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS04290	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS04295	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5Z25_RS04300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS04305	COG2188	Transcriptional regulator
C5Z25_RS04310	COG1216	Glycosyl transferase, family 2
C5Z25_RS04325	COG0406	alpha-ribazole phosphatase activity
C5Z25_RS04335	COG0561	phosphatase activity
C5Z25_RS04365	COG0710	3-dehydroquinate dehydratase activity
C5Z25_RS04370	COG0531	amino acid
C5Z25_RS04405	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5Z25_RS04420	COG4720	Psort location CytoplasmicMembrane, score
C5Z25_RS04425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5Z25_RS04430	COG0477	Major facilitator Superfamily
C5Z25_RS04450	COG4990	cell redox homeostasis
C5Z25_RS04475	COG3409	Peptidoglycan-binding domain 1 protein
C5Z25_RS04480	COG1811	Na channel or pump
C5Z25_RS04490	COG0577	efflux transmembrane transporter activity
C5Z25_RS04495	COG1136	(ABC) transporter
C5Z25_RS04530	COG2814	Major facilitator Superfamily
C5Z25_RS04540	COG2855	membrane
C5Z25_RS04545	COG0583	DNA-binding transcription factor activity
C5Z25_RS04565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5Z25_RS04570	COG4152	abc transporter atp-binding protein
C5Z25_RS04575	COG1668	transmembrane transport
C5Z25_RS04580	COG4221	oxidoreductase activity
C5Z25_RS04595	COG0789	Transcriptional regulator
C5Z25_RS04605	COG1302	Protein conserved in bacteria
C5Z25_RS04620	COG2261	transglycosylase associated protein
C5Z25_RS04635	COG0110	maltose O-acetyltransferase activity
C5Z25_RS04665	COG0589	response to stress
C5Z25_RS04670	COG0110	maltose O-acetyltransferase activity
C5Z25_RS04675	COG0604	alcohol dehydrogenase
C5Z25_RS04675	COG3321	synthase
C5Z25_RS04695	COG1132	(ABC) transporter
C5Z25_RS04700	COG1132	(ABC) transporter
C5Z25_RS04705	COG1511	domain protein
C5Z25_RS04705	COG1511	domain protein
C5Z25_RS04715	COG0640	Transcriptional regulator
C5Z25_RS04745	COG2814	Major facilitator Superfamily
C5Z25_RS04750	COG2151	metal-sulfur cluster biosynthetic enzyme
C5Z25_RS04755	COG0719	Fe-S assembly protein
C5Z25_RS04760	COG0822	iron-sulfur transferase activity
C5Z25_RS04765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5Z25_RS04770	COG0719	Fe-S assembly protein
C5Z25_RS04785	COG0488	(ABC) transporter
C5Z25_RS04790	COG0561	phosphatase activity
C5Z25_RS04805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5Z25_RS04810	COG0596	Alpha beta hydrolase
C5Z25_RS04815	COG0531	amino acid
C5Z25_RS04820	COG2270	Major facilitator Superfamily
C5Z25_RS04850	COG1162	GTPase activity
C5Z25_RS04890	COG0657	acetylesterase activity
C5Z25_RS04920	COG5001	Diguanylate cyclase
C5Z25_RS04920	COG3300	MHYT domain
C5Z25_RS04930	COG0602	queuosine metabolic process
C5Z25_RS04965	COG1940	carbohydrate kinase activity
C5Z25_RS04970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5Z25_RS04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS04975	COG2190	(PTS) system
C5Z25_RS04975	COG1263	PTS System
C5Z25_RS05005	COG0242	peptide deformylase activity
C5Z25_RS05025	COG0481	GTPase activity
C5Z25_RS05030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5Z25_RS05035	COG0583	DNA-binding transcription factor activity
C5Z25_RS05045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5Z25_RS05070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5Z25_RS05085	COG1136	(ABC) transporter
C5Z25_RS05085	COG0577	efflux transmembrane transporter activity
C5Z25_RS05100	COG2217	Heavy metal translocating P-type atpase
C5Z25_RS05120	COG3706	GGDEF domain
C5Z25_RS05125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5Z25_RS05130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5Z25_RS05135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5Z25_RS05160	COG4977	sequence-specific DNA binding
C5Z25_RS05160	COG1917	Cupin 2, conserved barrel domain protein
C5Z25_RS05165	COG0561	phosphatase activity
C5Z25_RS05170	COG1132	(ABC) transporter
C5Z25_RS05180	COG0604	alcohol dehydrogenase
C5Z25_RS05180	COG3321	synthase
C5Z25_RS05205	COG0697	spore germination
C5Z25_RS05210	COG0583	DNA-binding transcription factor activity
C5Z25_RS05225	COG2190	(PTS) system
C5Z25_RS05240	COG1464	Belongs to the NlpA lipoprotein family
C5Z25_RS05245	COG2011	ABC-type metal ion transport system permease component
C5Z25_RS05250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5Z25_RS05255	COG0667	Aldo Keto reductase
C5Z25_RS05300	COG0667	Aldo Keto reductase
C5Z25_RS05310	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS05315	COG2190	(PTS) system
C5Z25_RS05315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS05315	COG1263	PTS System
C5Z25_RS05325	COG0110	maltose O-acetyltransferase activity
C5Z25_RS05335	COG0667	Aldo Keto reductase
C5Z25_RS05345	COG0583	DNA-binding transcription factor activity
C5Z25_RS05350	COG1733	regulation of RNA biosynthetic process
C5Z25_RS05355	COG2814	Major facilitator Superfamily
C5Z25_RS05375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS05380	COG2188	Transcriptional regulator
C5Z25_RS05395	COG1914	H( )-stimulated, divalent metal cation uptake system
C5Z25_RS05405	COG2226	methyltransferase
C5Z25_RS05430	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C5Z25_RS05445	COG2160	L-arabinose isomerase activity
C5Z25_RS05470	COG0588	phosphoglycerate mutase activity
C5Z25_RS05475	COG0628	permease
C5Z25_RS05490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5Z25_RS05520	COG1247	-acetyltransferase
C5Z25_RS05525	COG1686	Belongs to the peptidase S11 family
C5Z25_RS05540	COG0516	GMP reductase activity
C5Z25_RS05540	COG0517	IMP dehydrogenase activity
C5Z25_RS05550	COG0012	GTP binding
C5Z25_RS05555	COG4481	Protein conserved in bacteria
C5Z25_RS05560	COG1475	DNA binding
C5Z25_RS05565	COG1192	Involved in chromosome partitioning
C5Z25_RS05575	COG0357	Ribosomal RNA small subunit methyltransferase G
C5Z25_RS05580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5Z25_RS05585	COG0583	DNA-binding transcription factor activity
C5Z25_RS05590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5Z25_RS05595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Z25_RS05600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Z25_RS05605	COG0765	amino acid transport
C5Z25_RS05610	COG1126	abc transporter atp-binding protein
C5Z25_RS05630	COG3706	GGDEF domain
C5Z25_RS05635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5Z25_RS05665	COG3976	FMN-binding domain protein
C5Z25_RS05665	COG1053	succinate dehydrogenase
C5Z25_RS05665	COG0431	NADPH-dependent FMN reductase
C5Z25_RS05675	COG0735	belongs to the Fur family
C5Z25_RS05700	COG1346	cytolysis
C5Z25_RS05705	COG1307	EDD domain protein, DegV family
C5Z25_RS05710	COG1053	succinate dehydrogenase
C5Z25_RS05710	COG0431	NADPH-dependent FMN reductase
C5Z25_RS05710	COG3976	FMN-binding domain protein
C5Z25_RS05715	COG0471	metal ion transport
C5Z25_RS05720	COG0583	DNA-binding transcription factor activity
C5Z25_RS05725	COG2738	Putative neutral zinc metallopeptidase
C5Z25_RS05735	COG1929	Belongs to the glycerate kinase type-1 family
C5Z25_RS05745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5Z25_RS05750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5Z25_RS05755	COG0516	GMP reductase activity
C5Z25_RS05760	COG2365	Tyrosine phosphatase family
C5Z25_RS05765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5Z25_RS05770	COG3158	transport of potassium into the cell
C5Z25_RS05775	COG0628	permease
C5Z25_RS05780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5Z25_RS05785	COG2076	Multidrug Resistance protein
C5Z25_RS05795	COG1272	protein, Hemolysin III
C5Z25_RS05800	COG0640	Transcriptional regulator
C5Z25_RS05805	COG1230	cation diffusion facilitator family transporter
C5Z25_RS05810	COG0519	Catalyzes the synthesis of GMP from XMP
C5Z25_RS05815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5Z25_RS05830	COG0302	gtp cyclohydrolase
C5Z25_RS05835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5Z25_RS05835	COG0302	gtp cyclohydrolase
C5Z25_RS05855	COG2814	Major facilitator Superfamily
C5Z25_RS05885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5Z25_RS05890	COG0667	Aldo Keto reductase
C5Z25_RS05905	COG2217	Heavy metal translocating P-type atpase
C5Z25_RS05910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5Z25_RS05915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5Z25_RS05920	COG1757	Na H antiporter
C5Z25_RS05925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5Z25_RS05935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5Z25_RS05940	COG1393	Belongs to the ArsC family
C5Z25_RS05945	COG3189	MarR family transcriptional regulator
C5Z25_RS05955	COG1194	a g-specific adenine glycosylase
C5Z25_RS05970	COG0071	Belongs to the small heat shock protein (HSP20) family
C5Z25_RS05995	COG1874	Beta-galactosidase
C5Z25_RS06000	COG1609	Transcriptional regulator
C5Z25_RS06010	COG0697	spore germination
C5Z25_RS06025	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C5Z25_RS06040	COG3706	GGDEF domain
C5Z25_RS06040	COG4251	negative regulation of phosphorylation
C5Z25_RS06040	COG5001	Diguanylate cyclase
C5Z25_RS06040	COG2203	Gaf domain
C5Z25_RS06060	COG0477	Major facilitator Superfamily
C5Z25_RS06100	COG3279	Response regulator of the LytR AlgR family
C5Z25_RS06135	COG0737	Belongs to the 5'-nucleotidase family
C5Z25_RS06140	COG0656	L-ascorbic acid biosynthetic process
C5Z25_RS06155	COG1968	undecaprenyl-diphosphatase activity
C5Z25_RS06160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5Z25_RS06260	COG0582	viral genome integration into host DNA
C5Z25_RS06265	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS06275	COG3711	transcriptional antiterminator
C5Z25_RS06280	COG0765	amino acid transport
C5Z25_RS06285	COG0765	amino acid transport
C5Z25_RS06290	COG1126	abc transporter atp-binding protein
C5Z25_RS06295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Z25_RS06300	COG2226	methyltransferase
C5Z25_RS06320	COG2217	Heavy metal translocating P-type atpase
C5Z25_RS06325	COG3118	belongs to the thioredoxin family
C5Z25_RS06330	COG1937	Protein conserved in bacteria
C5Z25_RS06350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5Z25_RS06365	COG1263	PTS System
C5Z25_RS06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS06365	COG2190	(PTS) system
C5Z25_RS06375	COG3590	peptidase
C5Z25_RS06385	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Z25_RS06420	COG0419	ATPase involved in DNA repair
C5Z25_RS06430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5Z25_RS06440	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Z25_RS06445	COG2190	(PTS) system
C5Z25_RS06445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS06445	COG1263	PTS System
C5Z25_RS06450	COG0698	ribose 5-phosphate isomerase
C5Z25_RS06455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5Z25_RS06460	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS06465	COG1609	Transcriptional regulator
C5Z25_RS06470	COG1609	Transcriptional regulator
C5Z25_RS06475	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C5Z25_RS06480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5Z25_RS06485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5Z25_RS06500	COG2211	Major facilitator Superfamily
C5Z25_RS06500	COG2190	(PTS) system
C5Z25_RS06505	COG2017	converts alpha-aldose to the beta-anomer
C5Z25_RS06520	COG0710	3-dehydroquinate dehydratase activity
C5Z25_RS06525	COG0738	Major facilitator superfamily
C5Z25_RS06530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5Z25_RS06535	COG0583	DNA-binding transcription factor activity
C5Z25_RS06540	COG0738	Major facilitator superfamily
C5Z25_RS06545	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS06550	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS06555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS06555	COG1263	PTS System
C5Z25_RS06555	COG2190	(PTS) system
C5Z25_RS06565	COG0546	phosphoglycolate phosphatase activity
C5Z25_RS06575	COG3732	PTS system glucitol sorbitol-specific
C5Z25_RS06580	COG3730	PTS system glucitol sorbitol-specific
C5Z25_RS06600	COG0235	Class ii aldolase
C5Z25_RS06605	COG4806	L-rhamnose isomerase
C5Z25_RS06610	COG3254	rhamnose metabolic process
C5Z25_RS06615	COG1070	Carbohydrate kinase
C5Z25_RS06640	COG4975	Glucose uptake
C5Z25_RS06645	COG2211	Major facilitator Superfamily
C5Z25_RS06650	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C5Z25_RS06655	COG2731	YhcH YjgK YiaL family protein
C5Z25_RS06660	COG3507	Belongs to the glycosyl hydrolase 43 family
C5Z25_RS06665	COG0561	phosphatase activity
C5Z25_RS06695	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C5Z25_RS06695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5Z25_RS06710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5Z25_RS06735	COG1609	Transcriptional regulator
C5Z25_RS06755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5Z25_RS06755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS06760	COG3716	PTS system mannose fructose sorbose family IID component
C5Z25_RS06765	COG3715	PTS system
C5Z25_RS06775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5Z25_RS06780	COG1609	Transcriptional regulator
C5Z25_RS06785	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C5Z25_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
C5Z25_RS06805	COG0800	Aldolase
C5Z25_RS06825	COG1454	alcohol dehydrogenase
C5Z25_RS06825	COG1012	belongs to the aldehyde dehydrogenase family
C5Z25_RS06845	COG1695	Transcriptional regulator
C5Z25_RS06850	COG3479	Phenolic acid decarboxylase
C5Z25_RS06860	COG1307	EDD domain protein, DegV family
C5Z25_RS06875	COG0445	tRNA wobble uridine modification
C5Z25_RS06880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5Z25_RS06885	COG1847	R3H domain protein
C5Z25_RS06890	COG0706	membrane insertase activity
C5Z25_RS06895	COG0594	ribonuclease P activity
C5Z25_RS06900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5Z25_RS06905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5Z25_RS06910	COG0592	DNA-directed DNA polymerase activity
C5Z25_RS06915	COG2501	S4 domain
C5Z25_RS06920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5Z25_RS06925	COG0187	DNA topoisomerase II activity
C5Z25_RS06935	COG0360	Binds together with S18 to 16S ribosomal RNA
C5Z25_RS06940	COG0629	single-stranded DNA binding
C5Z25_RS06945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5Z25_RS06975	COG0359	binds to the 23S rRNA
C5Z25_RS06980	COG0305	Participates in initiation and elongation during chromosome replication
C5Z25_RS06990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5Z25_RS06995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5Z25_RS07000	COG0561	phosphatase activity
C5Z25_RS07005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5Z25_RS07015	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS07020	COG5002	protein histidine kinase activity
C5Z25_RS07040	COG0463	Glycosyl transferase, family 2
C5Z25_RS07060	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS07065	COG5002	protein histidine kinase activity
C5Z25_RS07075	COG4853	Protein conserved in bacteria
C5Z25_RS07080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5Z25_RS07085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5Z25_RS07090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5Z25_RS07115	COG1857	crispr-associated protein
C5Z25_RS07130	COG1518	maintenance of DNA repeat elements
C5Z25_RS07135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5Z25_RS07165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5Z25_RS07175	COG3022	response to hydroperoxide
C5Z25_RS07180	COG0300	oxidoreductase activity
C5Z25_RS07190	COG0778	Nitroreductase
C5Z25_RS07195	COG2508	Transcriptional regulator
C5Z25_RS07230	COG1122	ATPase activity
C5Z25_RS07235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5Z25_RS07240	COG0310	cobalt ion transport
C5Z25_RS07245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5Z25_RS07250	COG3875	lactate racemase activity
C5Z25_RS07255	COG1691	(AIR) carboxylase
C5Z25_RS07260	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C5Z25_RS07265	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C5Z25_RS07270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5Z25_RS07275	COG1606	tRNA processing
C5Z25_RS07280	COG0531	amino acid
C5Z25_RS07290	COG1902	pentaerythritol trinitrate reductase activity
C5Z25_RS07295	COG0789	Transcriptional regulator
C5Z25_RS07305	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C5Z25_RS07310	COG0351	phosphomethylpyrimidine kinase
C5Z25_RS07315	COG0352	thiamine-phosphate diphosphorylase activity
C5Z25_RS07320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5Z25_RS07325	COG4166	transmembrane transport
C5Z25_RS07330	COG1053	succinate dehydrogenase
C5Z25_RS07340	COG1113	amino acid transport
C5Z25_RS07360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5Z25_RS07370	COG1983	PspC domain protein
C5Z25_RS07375	COG0431	NADPH-dependent FMN reductase
C5Z25_RS07395	COG2807	transmembrane transport
C5Z25_RS07400	COG0656	L-ascorbic acid biosynthetic process
C5Z25_RS07405	COG0667	Aldo Keto reductase
C5Z25_RS07415	COG1737	Transcriptional regulator
C5Z25_RS07420	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C5Z25_RS07425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS07425	COG2190	(PTS) system
C5Z25_RS07425	COG1263	PTS System
C5Z25_RS07430	COG1263	PTS System
C5Z25_RS07430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS07430	COG2190	(PTS) system
C5Z25_RS07440	COG4716	Myosin-crossreactive antigen
C5Z25_RS07450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS07455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS07460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS07465	COG2723	6-phospho-beta-galactosidase activity
C5Z25_RS07470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5Z25_RS07475	COG1122	ATPase activity
C5Z25_RS07480	COG4720	Psort location CytoplasmicMembrane, score
C5Z25_RS07490	COG2188	Transcriptional regulator
C5Z25_RS07515	COG1960	acyl-CoA dehydrogenase activity
C5Z25_RS07525	COG1609	Transcriptional regulator
C5Z25_RS07530	COG1609	Transcriptional regulator
C5Z25_RS07535	COG0366	Alpha amylase catalytic
C5Z25_RS07540	COG0366	Alpha amylase catalytic
C5Z25_RS07565	COG3842	ATPase activity
C5Z25_RS07600	COG1064	alcohol dehydrogenase
C5Z25_RS07605	COG1757	Na H antiporter
C5Z25_RS07620	COG4166	transmembrane transport
C5Z25_RS07625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5Z25_RS07630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5Z25_RS07635	COG0406	alpha-ribazole phosphatase activity
C5Z25_RS07660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5Z25_RS07665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5Z25_RS07670	COG0488	(ABC) transporter
C5Z25_RS07680	COG1122	ATPase activity
C5Z25_RS07690	COG0386	Belongs to the glutathione peroxidase family
C5Z25_RS07710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5Z25_RS07715	COG0363	glucosamine-6-phosphate deaminase activity
C5Z25_RS07725	COG2213	PTS system mannitol-specific
C5Z25_RS07735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5Z25_RS07740	COG0246	Mannitol dehydrogenase
C5Z25_RS07760	COG1373	ATPase (AAA superfamily
C5Z25_RS07795	COG2188	Transcriptional regulator
C5Z25_RS07800	COG0366	Alpha amylase catalytic
C5Z25_RS07805	COG1263	PTS System
C5Z25_RS07805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5Z25_RS07805	COG2190	(PTS) system
C5Z25_RS07820	COG0583	DNA-binding transcription factor activity
C5Z25_RS07825	COG0656	L-ascorbic acid biosynthetic process
C5Z25_RS07830	COG4975	Glucose uptake
C5Z25_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
C5Z25_RS07850	COG0656	L-ascorbic acid biosynthetic process
C5Z25_RS07855	COG0163	prenyltransferase activity
C5Z25_RS07870	COG1959	2 iron, 2 sulfur cluster binding
C5Z25_RS07875	COG1309	transcriptional regulator
C5Z25_RS07880	COG1914	H( )-stimulated, divalent metal cation uptake system
C5Z25_RS07900	COG5002	protein histidine kinase activity
C5Z25_RS07905	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS07920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS07945	COG2357	RelA SpoT domain protein
C5Z25_RS07960	COG2409	Drug exporters of the RND superfamily
C5Z25_RS07960	COG1033	growth of symbiont in host cell
C5Z25_RS07960	COG2409	Drug exporters of the RND superfamily
C5Z25_RS07960	COG1033	growth of symbiont in host cell
C5Z25_RS07965	COG2818	Glycosylase
C5Z25_RS07970	COG0028	Belongs to the TPP enzyme family
C5Z25_RS07975	COG2814	Major facilitator Superfamily
C5Z25_RS07985	COG0577	efflux transmembrane transporter activity
C5Z25_RS07990	COG1136	(ABC) transporter
C5Z25_RS07995	COG3103	Sh3 type 3 domain protein
C5Z25_RS07995	COG1388	LysM domain
C5Z25_RS07995	COG0791	NLP P60 protein
C5Z25_RS08055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5Z25_RS08060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5Z25_RS08075	COG1252	NADH dehydrogenase
C5Z25_RS08095	COG3842	ATPase activity
C5Z25_RS08120	COG1725	Transcriptional regulator
C5Z25_RS08125	COG1131	(ABC) transporter
C5Z25_RS08135	COG1454	alcohol dehydrogenase
C5Z25_RS08135	COG1012	belongs to the aldehyde dehydrogenase family
C5Z25_RS08170	COG2272	Belongs to the type-B carboxylesterase lipase family
C5Z25_RS08195	COG0004	ammonium transporteR
C5Z25_RS08215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5Z25_RS08235	COG3759	membrane
C5Z25_RS08240	COG1881	PFAM PEBP family protein
C5Z25_RS08265	COG4221	oxidoreductase activity
C5Z25_RS08270	COG0789	Transcriptional regulator
C5Z25_RS08275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5Z25_RS08285	COG0673	inositol 2-dehydrogenase activity
C5Z25_RS08290	COG0300	oxidoreductase activity
C5Z25_RS08310	COG0561	phosphatase activity
C5Z25_RS08315	COG3973	AAA domain
C5Z25_RS08320	COG0180	Tryptophanyl-tRNA synthetase
C5Z25_RS08325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5Z25_RS08345	COG1801	Protein of unknown function DUF72
C5Z25_RS08355	COG2851	Citrate transporter
C5Z25_RS08365	COG0511	ligase activity, forming carbon-carbon bonds
C5Z25_RS08370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C5Z25_RS08375	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C5Z25_RS08380	COG3052	prosthetic group binding
C5Z25_RS08415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Z25_RS08415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Z25_RS08420	COG0084	hydrolase, TatD family'
C5Z25_RS08425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C5Z25_RS08430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5Z25_RS08435	COG4466	Protein conserved in bacteria
C5Z25_RS08440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5Z25_RS08445	COG1073	alpha beta
C5Z25_RS08450	COG1121	(ABC) transporter
C5Z25_RS08455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5Z25_RS08455	COG1321	iron dependent repressor
C5Z25_RS08460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5Z25_RS08465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5Z25_RS08485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5Z25_RS08505	COG1078	dGTPase activity
C5Z25_RS08510	COG0095	Lipoate-protein ligase
C5Z25_RS08520	COG3343	RNA polymerase activity
C5Z25_RS08525	COG0504	CTP synthase activity
C5Z25_RS08530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5Z25_RS08535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5Z25_RS08540	COG0254	rRNA binding
C5Z25_RS08550	COG3764	Sortase (surface protein transpeptidase)
C5Z25_RS08555	COG1704	LemA family
C5Z25_RS08560	COG0501	Belongs to the peptidase M48B family
C5Z25_RS08570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5Z25_RS08580	COG0736	holo-[acyl-carrier-protein] synthase activity
C5Z25_RS08585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5Z25_RS08590	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5Z25_RS08595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5Z25_RS08600	COG0505	Belongs to the CarA family
C5Z25_RS08605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5Z25_RS08610	COG4708	membrane
C5Z25_RS08630	COG3279	Response regulator of the LytR AlgR family
C5Z25_RS08655	COG0193	aminoacyl-tRNA hydrolase activity
C5Z25_RS08660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5Z25_RS08665	COG2244	polysaccharide biosynthetic process
C5Z25_RS08670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5Z25_RS08680	COG1098	S1 RNA binding domain
C5Z25_RS08685	COG0037	tRNA processing
C5Z25_RS08700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5Z25_RS08705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5Z25_RS08710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5Z25_RS08750	COG3104	oligopeptide transport
C5Z25_RS08770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5Z25_RS08780	COG2188	Transcriptional regulator
C5Z25_RS08790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5Z25_RS08795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5Z25_RS08810	COG2183	response to ionizing radiation
C5Z25_RS08815	COG3091	SprT-like family
C5Z25_RS08820	COG0460	homoserine dehydrogenase
C5Z25_RS08825	COG0083	homoserine kinase activity
C5Z25_RS08850	COG3715	PTS system
C5Z25_RS08855	COG3716	PTS system mannose fructose sorbose family IID component
C5Z25_RS08865	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C5Z25_RS08865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5Z25_RS08880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5Z25_RS08885	COG0511	ligase activity, forming carbon-carbon bonds
C5Z25_RS08890	COG0439	Biotin carboxylase
C5Z25_RS08900	COG0825	malonyl-CoA metabolic process
C5Z25_RS08905	COG1316	TRANSCRIPTIONal
C5Z25_RS08915	COG0697	spore germination
C5Z25_RS08920	COG0588	phosphoglycerate mutase activity
C5Z25_RS08935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5Z25_RS08945	COG0756	dUTP diphosphatase activity
C5Z25_RS08950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5Z25_RS08955	COG4956	integral membrane protein (PIN domain superfamily)
C5Z25_RS08960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5Z25_RS08965	COG0215	cysteine-tRNA ligase activity
C5Z25_RS08970	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C5Z25_RS08975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5Z25_RS08990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5Z25_RS09000	COG0250	Participates in transcription elongation, termination and antitermination
C5Z25_RS09010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5Z25_RS09015	COG0081	regulation of translation
C5Z25_RS09020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5Z25_RS09025	COG0222	ribosome binding
C5Z25_RS09040	COG0392	lysyltransferase activity
C5Z25_RS09040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5Z25_RS09045	COG1611	Belongs to the LOG family
C5Z25_RS09055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5Z25_RS09060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5Z25_RS09065	COG2813	Specifically methylates the guanine in position
C5Z25_RS09070	COG0590	tRNA wobble adenosine to inosine editing
C5Z25_RS09080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5Z25_RS09085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5Z25_RS09090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5Z25_RS09100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5Z25_RS09105	COG3870	Protein conserved in bacteria
C5Z25_RS09110	COG0470	DNA polymerase III
C5Z25_RS09115	COG4467	Involved in initiation control of chromosome replication
C5Z25_RS09130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5Z25_RS09135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5Z25_RS09140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5Z25_RS09155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C5Z25_RS09165	COG1214	PFAM Peptidase M22, glycoprotease
C5Z25_RS09170	COG0456	acetyltransferase
C5Z25_RS09170	COG1214	PFAM Peptidase M22, glycoprotease
C5Z25_RS09175	COG0456	acetyltransferase
C5Z25_RS09180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5Z25_RS09185	COG0488	(ABC) transporter
C5Z25_RS09190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5Z25_RS09200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5Z25_RS09205	COG0459	protein refolding
C5Z25_RS09210	COG0531	amino acid
C5Z25_RS09215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5Z25_RS09220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5Z25_RS09225	COG1739	Uncharacterized protein family UPF0029
C5Z25_RS09230	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C5Z25_RS09235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5Z25_RS09245	COG0653	protein targeting
C5Z25_RS09255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5Z25_RS09260	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS09265	COG5002	protein histidine kinase activity
C5Z25_RS09275	COG0573	inorganic phosphate transmembrane transporter activity
C5Z25_RS09280	COG0581	inorganic phosphate transmembrane transporter activity
C5Z25_RS09285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5Z25_RS09290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5Z25_RS09295	COG0704	Plays a role in the regulation of phosphate uptake
C5Z25_RS09300	COG1983	PspC domain protein
C5Z25_RS09305	COG1950	PFAM Membrane protein of
C5Z25_RS09310	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5Z25_RS09315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5Z25_RS09320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5Z25_RS09325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5Z25_RS09340	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Z25_RS09350	COG0492	ferredoxin-NADP+ reductase activity
C5Z25_RS09360	COG2323	membrane
C5Z25_RS09370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5Z25_RS09380	COG2814	Major facilitator Superfamily
C5Z25_RS09390	COG0556	nucleotide-excision repair
C5Z25_RS09395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5Z25_RS09400	COG1854	S-ribosylhomocysteine lyase activity
C5Z25_RS09405	COG0137	argininosuccinate synthase activity
C5Z25_RS09410	COG0165	Argininosuccinate lyase
C5Z25_RS09415	COG0393	Putative heavy-metal-binding
C5Z25_RS09425	COG1660	Displays ATPase and GTPase activities
C5Z25_RS09430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5Z25_RS09435	COG1481	regulation of sporulation
C5Z25_RS09440	COG2315	Protein conserved in bacteria
C5Z25_RS09450	COG0740	serine-type endopeptidase activity
C5Z25_RS09460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5Z25_RS09465	COG2390	Transcriptional regulator
C5Z25_RS09475	COG0126	phosphoglycerate kinase activity
C5Z25_RS09480	COG0149	triose-phosphate isomerase activity
C5Z25_RS09485	COG0148	phosphopyruvate hydratase activity
C5Z25_RS09490	COG0028	Belongs to the TPP enzyme family
C5Z25_RS09500	COG0038	chloride channel
C5Z25_RS09505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5Z25_RS09515	COG0557	exoribonuclease II activity
C5Z25_RS09520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5Z25_RS09525	COG0765	amino acid transport
C5Z25_RS09530	COG1126	abc transporter atp-binding protein
C5Z25_RS09555	COG0561	phosphatase activity
C5Z25_RS09560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5Z25_RS09565	COG0280	phosphate acetyltransferase
C5Z25_RS09570	COG0802	atpase or kinase
C5Z25_RS09585	COG0708	Exodeoxyribonuclease III
C5Z25_RS09595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5Z25_RS09625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5Z25_RS09630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5Z25_RS09635	COG0561	phosphatase activity
C5Z25_RS09640	COG2017	converts alpha-aldose to the beta-anomer
C5Z25_RS09645	COG1134	teichoic acid transport
C5Z25_RS09660	COG0778	Nitroreductase
C5Z25_RS09695	COG1881	PFAM PEBP family protein
C5Z25_RS09700	COG0248	Ppx GppA phosphatase
C5Z25_RS09705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5Z25_RS09715	COG3475	LICD family
C5Z25_RS09730	COG2252	PERMEase
C5Z25_RS09735	COG2267	carboxylic ester hydrolase activity
C5Z25_RS09740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C5Z25_RS09740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C5Z25_RS09745	COG1268	BioY protein
C5Z25_RS09750	COG2755	lipolytic protein G-D-S-L family
C5Z25_RS09750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5Z25_RS09775	COG2936	dipeptidyl-peptidase activity
C5Z25_RS09790	COG0531	amino acid
C5Z25_RS09810	COG0194	GDP metabolic process
C5Z25_RS09815	COG0735	belongs to the Fur family
C5Z25_RS09840	COG0546	phosphoglycolate phosphatase activity
C5Z25_RS09845	COG0436	Aminotransferase
C5Z25_RS09850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5Z25_RS09860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5Z25_RS09865	COG0765	amino acid transport
C5Z25_RS09870	COG0765	amino acid transport
C5Z25_RS09875	COG0531	amino acid
C5Z25_RS09885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5Z25_RS09895	COG2076	Multidrug Resistance protein
C5Z25_RS09900	COG0406	alpha-ribazole phosphatase activity
C5Z25_RS09905	COG0588	phosphoglycerate mutase activity
C5Z25_RS09910	COG0475	glutathione-regulated potassium exporter activity
C5Z25_RS09910	COG0569	domain protein
C5Z25_RS09920	COG0586	Pfam SNARE associated Golgi protein
C5Z25_RS09925	COG3973	AAA domain
C5Z25_RS09930	COG1072	(Pantothenic acid kinase))
C5Z25_RS09935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5Z25_RS09935	COG0519	Catalyzes the synthesis of GMP from XMP
C5Z25_RS09945	COG0308	aminopeptidase N
C5Z25_RS09955	COG2502	aspartate--ammonia ligase
C5Z25_RS09960	COG4690	dipeptidase activity
C5Z25_RS09970	COG0514	ATP-dependent DNA helicase (RecQ)
C5Z25_RS09975	COG0564	pseudouridine synthase activity
C5Z25_RS09980	COG0640	Transcriptional regulator
C5Z25_RS10020	COG0588	phosphoglycerate mutase activity
C5Z25_RS10025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5Z25_RS10035	COG0583	DNA-binding transcription factor activity
C5Z25_RS10055	COG3052	prosthetic group binding
C5Z25_RS10070	COG2267	carboxylic ester hydrolase activity
C5Z25_RS10080	COG0527	aspartate kinase activity
C5Z25_RS10085	COG0367	asparagine synthase
C5Z25_RS10115	COG2814	Major facilitator Superfamily
C5Z25_RS10135	COG1278	Cold shock
C5Z25_RS10150	COG1316	TRANSCRIPTIONal
C5Z25_RS10175	COG0028	Belongs to the TPP enzyme family
C5Z25_RS10180	COG0833	amino acid
C5Z25_RS10190	COG1428	Deoxynucleoside kinase
C5Z25_RS10195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5Z25_RS10235	COG4463	regulation of RNA biosynthetic process
C5Z25_RS10240	COG0542	response to heat
C5Z25_RS10250	COG0085	RNA polymerase activity
C5Z25_RS10255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5Z25_RS10260	COG2030	dehydratase
C5Z25_RS10265	COG1024	Enoyl-CoA hydratase
C5Z25_RS10270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5Z25_RS10275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5Z25_RS10285	COG0583	DNA-binding transcription factor activity
C5Z25_RS10300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5Z25_RS10305	COG0049	tRNA binding
C5Z25_RS10310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5Z25_RS10315	COG0051	transcription antitermination factor activity, RNA binding
C5Z25_RS10320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5Z25_RS10325	COG0088	Forms part of the polypeptide exit tunnel
C5Z25_RS10330	COG0089	rRNA binding
C5Z25_RS10335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5Z25_RS10340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5Z25_RS10345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5Z25_RS10350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5Z25_RS10355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5Z25_RS10360	COG0255	Belongs to the universal ribosomal protein uL29 family
C5Z25_RS10365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5Z25_RS10370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5Z25_RS10375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5Z25_RS10380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5Z25_RS10385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5Z25_RS10390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5Z25_RS10395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5Z25_RS10400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5Z25_RS10405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5Z25_RS10410	COG1841	ribosomal large subunit assembly
C5Z25_RS10415	COG0200	Binds to the 23S rRNA
C5Z25_RS10425	COG0563	adenylate kinase activity
C5Z25_RS10430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5Z25_RS10435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5Z25_RS10440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5Z25_RS10445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5Z25_RS10450	COG0202	RNA polymerase activity
C5Z25_RS10455	COG0203	ribosomal protein L17
C5Z25_RS10475	COG1252	NADH dehydrogenase
C5Z25_RS10480	COG4939	FMN-binding domain protein
C5Z25_RS10490	COG1122	ATPase activity
C5Z25_RS10495	COG1122	ATPase activity
C5Z25_RS10505	COG0101	tRNA pseudouridine synthase activity
C5Z25_RS10510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5Z25_RS10515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5Z25_RS10520	COG1121	(ABC) transporter
C5Z25_RS10525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5Z25_RS10530	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5Z25_RS10540	COG0583	DNA-binding transcription factor activity
C5Z25_RS10545	COG0281	malic enzyme
C5Z25_RS10555	COG0531	amino acid
C5Z25_RS10560	COG4684	Psort location CytoplasmicMembrane, score
C5Z25_RS10565	COG1271	oxidase subunit
C5Z25_RS10570	COG1294	oxidase, subunit
C5Z25_RS10575	COG4988	ABC transporter
C5Z25_RS10580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5Z25_RS10585	COG0142	geranyltranstransferase activity
C5Z25_RS10600	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5Z25_RS10605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5Z25_RS10610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5Z25_RS10620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5Z25_RS10625	COG4851	CamS sex pheromone cAM373 precursor
C5Z25_RS10630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5Z25_RS10635	COG0154	amidase activity
C5Z25_RS10640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5Z25_RS10650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5Z25_RS10685	COG2814	Major facilitator Superfamily
C5Z25_RS10705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5Z25_RS10715	COG1737	Transcriptional regulator
C5Z25_RS10720	COG3757	hydrolase, family 25
C5Z25_RS10720	COG3409	Peptidoglycan-binding domain 1 protein
C5Z25_RS10730	COG0673	inositol 2-dehydrogenase activity
C5Z25_RS10755	COG1131	(ABC) transporter
C5Z25_RS10790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5Z25_RS10805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5Z25_RS10810	COG0463	Glycosyl transferase, family 2
C5Z25_RS10815	COG1295	ribonuclease BN
C5Z25_RS10820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5Z25_RS10845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5Z25_RS10860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5Z25_RS10865	COG0438	transferase activity, transferring glycosyl groups
C5Z25_RS10880	COG1216	Glycosyl transferase, family 2
C5Z25_RS10895	COG0562	UDP-galactopyranose mutase
C5Z25_RS10930	COG1215	transferase activity, transferring glycosyl groups
C5Z25_RS10935	COG0438	transferase activity, transferring glycosyl groups
C5Z25_RS10940	COG0438	transferase activity, transferring glycosyl groups
C5Z25_RS10955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5Z25_RS10990	COG2137	regulation of response to DNA damage stimulus
C5Z25_RS10995	COG3557	Belongs to the UPF0374 family
C5Z25_RS11015	COG0628	permease
C5Z25_RS11020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5Z25_RS11025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5Z25_RS11030	COG4975	Glucose uptake
C5Z25_RS11055	COG4166	transmembrane transport
C5Z25_RS11060	COG0601	transmembrane transport
C5Z25_RS11065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5Z25_RS11070	COG0444	Belongs to the ABC transporter superfamily
C5Z25_RS11075	COG4608	Belongs to the ABC transporter superfamily
C5Z25_RS11080	COG1309	transcriptional regulator
C5Z25_RS11085	COG2084	Dehydrogenase
C5Z25_RS11095	COG0328	RNA-DNA hybrid ribonuclease activity
C5Z25_RS11105	COG0542	response to heat
C5Z25_RS11115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5Z25_RS11125	COG0438	transferase activity, transferring glycosyl groups
C5Z25_RS11130	COG0438	transferase activity, transferring glycosyl groups
C5Z25_RS11140	COG1686	Belongs to the peptidase S11 family
C5Z25_RS11145	COG0436	Aminotransferase
C5Z25_RS11150	COG4703	Protein of unknown function (DUF1797)
C5Z25_RS11155	COG1368	sulfuric ester hydrolase activity
C5Z25_RS11275	COG0833	amino acid
C5Z25_RS11280	COG2040	homocysteine
C5Z25_RS11290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5Z25_RS11295	COG2814	Major facilitator Superfamily
C5Z25_RS11300	COG0671	phosphoesterase, PA-phosphatase related
C5Z25_RS11305	COG0495	leucyl-tRNA aminoacylation
C5Z25_RS11310	COG2244	polysaccharide biosynthetic process
C5Z25_RS11315	COG1187	pseudouridine synthase activity
C5Z25_RS11325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5Z25_RS11330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5Z25_RS11335	COG0589	response to stress
C5Z25_RS11340	COG0584	glycerophosphoryl diester phosphodiesterase
C5Z25_RS11345	COG1428	Deoxynucleoside kinase
C5Z25_RS11350	COG1970	mechanosensitive ion channel activity
C5Z25_RS11355	COG0561	phosphatase activity
C5Z25_RS11370	COG3279	Response regulator of the LytR AlgR family
C5Z25_RS11390	COG1846	Transcriptional regulator
C5Z25_RS11430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5Z25_RS11430	COG0646	methionine synthase
C5Z25_RS11435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5Z25_RS11445	COG2046	Belongs to the sulfate adenylyltransferase family
C5Z25_RS11450	COG0529	Catalyzes the synthesis of activated sulfate
C5Z25_RS11455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5Z25_RS11465	COG0471	metal ion transport
C5Z25_RS11465	COG3273	potassium ion transport
C5Z25_RS11470	COG0534	Mate efflux family protein
C5Z25_RS11485	COG2153	protein acetylation
C5Z25_RS11490	COG0018	arginyl-trna synthetase
C5Z25_RS11495	COG1136	(ABC) transporter
C5Z25_RS11495	COG0577	efflux transmembrane transporter activity
C5Z25_RS11510	COG1131	(ABC) transporter
C5Z25_RS11520	COG1309	transcriptional regulator
C5Z25_RS11535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5Z25_RS11550	COG1438	arginine binding
C5Z25_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5Z25_RS11565	COG3679	Belongs to the UPF0342 family
C5Z25_RS11570	COG0420	3'-5' exonuclease activity
C5Z25_RS11575	COG4717	serine-type aminopeptidase activity
C5Z25_RS11580	COG3481	metal-dependent phosphohydrolase, HD sub domain
C5Z25_RS11585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5Z25_RS11595	COG0537	adenosine 5'-monophosphoramidase activity
C5Z25_RS11600	COG1131	(ABC) transporter
C5Z25_RS11610	COG0510	thiamine kinase activity
C5Z25_RS11615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5Z25_RS11630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Z25_RS11635	COG1674	ftsk spoiiie
C5Z25_RS11640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5Z25_RS11690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Z25_RS11690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5Z25_RS11695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5Z25_RS11700	COG0237	dephospho-CoA kinase activity
C5Z25_RS11705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5Z25_RS11710	COG3611	Membrane attachment protein
C5Z25_RS11715	COG1484	DNA-dependent DNA replication
C5Z25_RS11720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5Z25_RS11725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5Z25_RS11730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5Z25_RS11735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5Z25_RS11740	COG1846	Transcriptional regulator
C5Z25_RS11755	COG1215	transferase activity, transferring glycosyl groups
C5Z25_RS11765	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C5Z25_RS11770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5Z25_RS11775	COG1534	Rna-binding protein
C5Z25_RS11780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5Z25_RS11785	COG1713	HD superfamily hydrolase involved in NAD metabolism
C5Z25_RS11790	COG0799	negative regulation of ribosome biogenesis
C5Z25_RS11795	COG2226	methyltransferase
C5Z25_RS11800	COG1323	Belongs to the UPF0348 family
C5Z25_RS11810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5Z25_RS11815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5Z25_RS11825	COG0745	RESPONSE REGULATOR receiver
C5Z25_RS11830	COG5002	protein histidine kinase activity
C5Z25_RS11840	COG0706	membrane insertase activity
C5Z25_RS11845	COG1254	Belongs to the acylphosphatase family
C5Z25_RS11850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5Z25_RS11860	COG1733	regulation of RNA biosynthetic process
C5Z25_RS11865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5Z25_RS11870	COG0072	phenylalanine-tRNA ligase activity
C5Z25_RS11870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5Z25_RS11875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5Z25_RS11880	COG0572	uridine kinase
C5Z25_RS11885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5Z25_RS11900	COG4221	oxidoreductase activity
C5Z25_RS11905	COG0789	Transcriptional regulator
C5Z25_RS11910	COG4841	protein insertion into membrane
C5Z25_RS11920	COG0768	penicillin binding
C5Z25_RS11925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5Z25_RS11930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5Z25_RS11945	COG1940	carbohydrate kinase activity
C5Z25_RS11950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5Z25_RS11960	COG0584	glycerophosphoryl diester phosphodiesterase
C5Z25_RS11965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5Z25_RS11970	COG0789	Transcriptional regulator
C5Z25_RS12175	COG2826	transposase and inactivated derivatives, IS30 family
C5Z25_RS12185	COG3158	transport of potassium into the cell
C5Z25_RS12195	COG1846	Transcriptional regulator
C5Z25_RS12260	COG0582	viral genome integration into host DNA
C5Z25_RS12295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5Z25_RS12315	COG1192	Involved in chromosome partitioning
C5Z25_RS12375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5Z25_RS12390	COG0783	Belongs to the Dps family
C5Z25_RS12450	COG0582	viral genome integration into host DNA
C5Z25_RS12475	COG3409	Peptidoglycan-binding domain 1 protein
C5Z25_RS12485	COG0783	Belongs to the Dps family