locus-tag	class	description
ELX58_RS00010	COG0592	DNA-directed DNA polymerase activity
ELX58_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ELX58_RS00025	COG0187	DNA topoisomerase II activity
ELX58_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ELX58_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
ELX58_RS00040	COG0629	single-stranded DNA binding
ELX58_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ELX58_RS00055	COG0359	binds to the 23S rRNA
ELX58_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
ELX58_RS00075	COG0745	RESPONSE REGULATOR receiver
ELX58_RS00080	COG5002	protein histidine kinase activity
ELX58_RS00095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ELX58_RS00100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ELX58_RS00105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ELX58_RS00110	COG3620	sequence-specific DNA binding
ELX58_RS00120	COG4221	oxidoreductase activity
ELX58_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ELX58_RS00130	COG1957	nucleoside hydrolase
ELX58_RS00150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ELX58_RS00155	COG2226	methyltransferase
ELX58_RS00160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ELX58_RS00165	COG0531	amino acid
ELX58_RS00175	COG0693	protein deglycase activity
ELX58_RS00190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ELX58_RS00200	COG0489	protein tyrosine kinase activity
ELX58_RS00205	COG2801	Transposase and inactivated derivatives
ELX58_RS00210	COG1914	H( )-stimulated, divalent metal cation uptake system
ELX58_RS00225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ELX58_RS00265	COG2814	Major facilitator Superfamily
ELX58_RS00270	COG0531	amino acid
ELX58_RS00275	COG0531	amino acid
ELX58_RS00280	COG1113	amino acid transport
ELX58_RS00300	COG1272	protein, Hemolysin III
ELX58_RS00310	COG1929	Belongs to the glycerate kinase type-1 family
ELX58_RS00320	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ELX58_RS00340	COG3103	Sh3 type 3 domain protein
ELX58_RS00340	COG1388	LysM domain
ELX58_RS00340	COG0791	NLP P60 protein
ELX58_RS00345	COG0531	amino acid
ELX58_RS00405	COG2801	Transposase and inactivated derivatives
ELX58_RS00475	COG2244	polysaccharide biosynthetic process
ELX58_RS00480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ELX58_RS00485	COG3442	glutamine amidotransferase
ELX58_RS00495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ELX58_RS00500	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ELX58_RS00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ELX58_RS00510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ELX58_RS00515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ELX58_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
ELX58_RS00535	COG0439	Biotin carboxylase
ELX58_RS00540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ELX58_RS00545	COG0825	malonyl-CoA metabolic process
ELX58_RS00550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ELX58_RS00560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ELX58_RS00560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ELX58_RS00565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ELX58_RS00570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ELX58_RS00595	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ELX58_RS00600	COG0357	Ribosomal RNA small subunit methyltransferase G
ELX58_RS00605	COG1192	Involved in chromosome partitioning
ELX58_RS00610	COG1475	DNA binding
ELX58_RS00615	COG4481	Protein conserved in bacteria
ELX58_RS00620	COG0012	GTP binding
ELX58_RS00640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ELX58_RS00645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ELX58_RS00655	COG0588	phosphoglycerate mutase activity
ELX58_RS00660	COG2814	Major facilitator Superfamily
ELX58_RS00730	COG3091	SprT-like family
ELX58_RS00735	COG0083	homoserine kinase activity
ELX58_RS00815	COG0656	L-ascorbic acid biosynthetic process
ELX58_RS00820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ELX58_RS00825	COG2094	Belongs to the DNA glycosylase MPG family
ELX58_RS00830	COG0697	spore germination
ELX58_RS00860	COG2249	NAD(P)H dehydrogenase (quinone) activity
ELX58_RS00865	COG0351	phosphomethylpyrimidine kinase
ELX58_RS00870	COG0328	RNA-DNA hybrid ribonuclease activity
ELX58_RS00875	COG0110	maltose O-acetyltransferase activity
ELX58_RS00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ELX58_RS00900	COG0024	Methionine aminopeptidase
ELX58_RS00910	COG2814	Major facilitator Superfamily
ELX58_RS00915	COG3590	peptidase
ELX58_RS00930	COG4946	Tricorn protease homolog
ELX58_RS00930	COG1506	peptidase
ELX58_RS00930	COG0823	Involved in the tonB-independent uptake of proteins
ELX58_RS00935	COG2706	6-phosphogluconolactonase activity
ELX58_RS00950	COG1307	EDD domain protein, DegV family
ELX58_RS00955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ELX58_RS00990	COG1122	ATPase activity
ELX58_RS01000	COG1686	Belongs to the peptidase S11 family
ELX58_RS01055	COG0477	Major facilitator Superfamily
ELX58_RS01085	COG0531	amino acid
ELX58_RS01095	COG0488	(ABC) transporter
ELX58_RS01105	COG2267	carboxylic ester hydrolase activity
ELX58_RS01110	COG2936	dipeptidyl-peptidase activity
ELX58_RS01140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ELX58_RS01150	COG3973	AAA domain
ELX58_RS01155	COG1072	(Pantothenic acid kinase))
ELX58_RS01160	COG0564	pseudouridine synthase activity
ELX58_RS01205	COG0657	acetylesterase activity
ELX58_RS01215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ELX58_RS01265	COG4463	regulation of RNA biosynthetic process
ELX58_RS01270	COG0542	response to heat
ELX58_RS01275	COG0085	RNA polymerase activity
ELX58_RS01280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ELX58_RS01285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ELX58_RS01290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ELX58_RS01295	COG0049	tRNA binding
ELX58_RS01300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ELX58_RS01305	COG0051	transcription antitermination factor activity, RNA binding
ELX58_RS01310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ELX58_RS01315	COG0088	Forms part of the polypeptide exit tunnel
ELX58_RS01320	COG0089	rRNA binding
ELX58_RS01325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ELX58_RS01330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ELX58_RS01335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ELX58_RS01345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ELX58_RS01355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ELX58_RS01360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ELX58_RS01365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ELX58_RS01370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ELX58_RS01375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ELX58_RS01380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ELX58_RS01385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ELX58_RS01390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ELX58_RS01395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ELX58_RS01400	COG1841	ribosomal large subunit assembly
ELX58_RS01405	COG0200	Binds to the 23S rRNA
ELX58_RS01420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ELX58_RS01425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ELX58_RS01430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ELX58_RS01435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ELX58_RS01440	COG0202	RNA polymerase activity
ELX58_RS01445	COG0203	ribosomal protein L17
ELX58_RS01450	COG1122	ATPase activity
ELX58_RS01455	COG1122	ATPase activity
ELX58_RS01465	COG0101	tRNA pseudouridine synthase activity
ELX58_RS01470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ELX58_RS01475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ELX58_RS01500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ELX58_RS01505	COG0154	amidase activity
ELX58_RS01510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ELX58_RS01515	COG1597	lipid kinase activity
ELX58_RS01520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ELX58_RS01525	COG1070	Carbohydrate kinase
ELX58_RS01545	COG4975	Glucose uptake
ELX58_RS01555	COG0463	Glycosyl transferase, family 2
ELX58_RS01560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ELX58_RS01565	COG1295	ribonuclease BN
ELX58_RS01570	COG0716	FMN binding
ELX58_RS01575	COG0628	permease
ELX58_RS01585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ELX58_RS01595	COG0542	response to heat
ELX58_RS01605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ELX58_RS01610	COG0438	transferase activity, transferring glycosyl groups
ELX58_RS01615	COG0438	transferase activity, transferring glycosyl groups
ELX58_RS01625	COG1368	sulfuric ester hydrolase activity
ELX58_RS01675	COG1234	tRNA 3'-trailer cleavage
ELX58_RS01680	COG4862	establishment of competence for transformation
ELX58_RS01685	COG4862	establishment of competence for transformation
ELX58_RS01700	COG2357	RelA SpoT domain protein
ELX58_RS01705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ELX58_RS01710	COG0564	pseudouridine synthase activity
ELX58_RS01730	COG0275	rRNA processing
ELX58_RS01740	COG0768	penicillin binding
ELX58_RS01745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ELX58_RS01750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ELX58_RS01755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ELX58_RS01770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ELX58_RS01780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ELX58_RS01785	COG3599	regulation of cell shape
ELX58_RS01790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ELX58_RS01800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ELX58_RS01805	COG1104	cysteine desulfurase activity
ELX58_RS01815	COG0482	sulfurtransferase activity
ELX58_RS01830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ELX58_RS01835	COG0667	Aldo Keto reductase
ELX58_RS01840	COG1597	lipid kinase activity
ELX58_RS01850	COG5503	Protein of unknown function (DUF1447)
ELX58_RS01860	COG0242	peptide deformylase activity
ELX58_RS01865	COG1217	gtp-binding protein TYPA
ELX58_RS01870	COG0772	Belongs to the SEDS family
ELX58_RS01875	COG4471	UPF0298 protein
ELX58_RS01880	COG0742	ribosomal rna small subunit methyltransferase
ELX58_RS01885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ELX58_RS01890	COG3480	Lon protease (S16) C-terminal proteolytic domain
ELX58_RS01900	COG2131	deaminase
ELX58_RS01905	COG0658	competence protein
ELX58_RS01905	COG2333	competence protein COMEC
ELX58_RS01910	COG1466	dna polymerase III delta subunit
ELX58_RS01915	COG0268	Binds directly to 16S ribosomal RNA
ELX58_RS01935	COG0544	peptidyl-prolyl cis-trans isomerase activity
ELX58_RS01940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ELX58_RS01945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ELX58_RS01950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ELX58_RS01955	COG1234	tRNA 3'-trailer cleavage
ELX58_RS01960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ELX58_RS01960	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ELX58_RS01965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ELX58_RS01975	COG4224	UPF0291 protein
ELX58_RS01980	COG3763	UPF0154 protein
ELX58_RS01985	COG0204	Acyl-transferase
ELX58_RS01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ELX58_RS02000	COG0052	Belongs to the universal ribosomal protein uS2 family
ELX58_RS02005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ELX58_RS02015	COG0233	cytoplasmic translational termination
ELX58_RS02025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ELX58_RS02030	COG4589	Belongs to the CDS family
ELX58_RS02035	COG0750	zinc metalloprotease
ELX58_RS02040	COG0442	prolyl-tRNA aminoacylation
ELX58_RS02050	COG0779	Required for maturation of 30S ribosomal subunits
ELX58_RS02055	COG0195	Participates in both transcription termination and antitermination
ELX58_RS02070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ELX58_RS02075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ELX58_RS02080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ELX58_RS02085	COG0196	riboflavin kinase activity
ELX58_RS02090	COG1420	regulation of RNA biosynthetic process
ELX58_RS02095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ELX58_RS02105	COG0484	heat shock protein binding
ELX58_RS02110	COG0481	GTPase activity
ELX58_RS02120	COG0463	Glycosyl transferase, family 2
ELX58_RS02120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ELX58_RS02125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ELX58_RS02125	COG0463	Glycosyl transferase, family 2
ELX58_RS02145	COG1490	D-aminoacyl-tRNA deacylase activity
ELX58_RS02150	COG3001	Fructosamine kinase
ELX58_RS02155	COG0124	histidyl-tRNA synthetase
ELX58_RS02160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ELX58_RS02165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ELX58_RS02175	COG1682	transport, permease protein
ELX58_RS02180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ELX58_RS02185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ELX58_RS02195	COG1702	phosphate starvation-inducible protein PhoH
ELX58_RS02200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ELX58_RS02210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ELX58_RS02215	COG1381	Involved in DNA repair and RecF pathway recombination
ELX58_RS02225	COG0751	glycine-tRNA ligase activity
ELX58_RS02230	COG0358	DNA primase activity
ELX58_RS02235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ELX58_RS02240	COG2384	SAM-dependent methyltransferase
ELX58_RS02245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ELX58_RS02250	COG0542	response to heat
ELX58_RS02255	COG2936	dipeptidyl-peptidase activity
ELX58_RS02270	COG1307	EDD domain protein, DegV family
ELX58_RS02290	COG0587	DNA-directed DNA polymerase activity
ELX58_RS02315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ELX58_RS02320	COG1187	pseudouridine synthase activity
ELX58_RS02330	COG0514	ATP-dependent DNA helicase (RecQ)
ELX58_RS02340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ELX58_RS02345	COG0539	negative regulation of cytoplasmic translation
ELX58_RS02350	COG1160	GTP binding
ELX58_RS02365	COG0488	(ABC) transporter
ELX58_RS02375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ELX58_RS02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ELX58_RS02405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ELX58_RS02415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ELX58_RS02420	COG0187	DNA topoisomerase II activity
ELX58_RS02430	COG1227	inorganic diphosphatase activity
ELX58_RS02445	COG0436	Aminotransferase
ELX58_RS02455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ELX58_RS02490	COG0561	phosphatase activity
ELX58_RS02505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ELX58_RS02525	COG4974	Belongs to the 'phage' integrase family
ELX58_RS02545	COG0531	amino acid
ELX58_RS02565	COG1285	pathogenesis
ELX58_RS02580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ELX58_RS02585	COG1956	GAF domain-containing protein
ELX58_RS02605	COG4975	Glucose uptake
ELX58_RS02625	COG1396	sequence-specific DNA binding
ELX58_RS02635	COG0824	Thioesterase
ELX58_RS02655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ELX58_RS02660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ELX58_RS02685	COG1335	isochorismatase
ELX58_RS02690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ELX58_RS02695	COG4221	oxidoreductase activity
ELX58_RS02700	COG4975	Glucose uptake
ELX58_RS02705	COG4975	Glucose uptake
ELX58_RS02710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ELX58_RS02715	COG2137	regulation of response to DNA damage stimulus
ELX58_RS02720	COG0017	Asparaginyl-tRNA synthetase
ELX58_RS02735	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
ELX58_RS02760	COG0737	Belongs to the 5'-nucleotidase family
ELX58_RS02775	COG2814	Major facilitator Superfamily
ELX58_RS02795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ELX58_RS02805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ELX58_RS02825	COG0351	phosphomethylpyrimidine kinase
ELX58_RS02840	COG0308	aminopeptidase N
ELX58_RS02850	COG0719	Fe-S assembly protein
ELX58_RS02860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ELX58_RS02865	COG0719	Fe-S assembly protein
ELX58_RS02870	COG0396	ATPase activity
ELX58_RS02905	COG1435	thymidine kinase activity
ELX58_RS02950	COG0028	Belongs to the TPP enzyme family
ELX58_RS02960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ELX58_RS02980	COG4975	Glucose uptake
ELX58_RS02995	COG1074	ATP-dependent DNA helicase activity
ELX58_RS03000	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ELX58_RS03065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ELX58_RS03070	COG0531	amino acid
ELX58_RS03075	COG2011	ABC-type metal ion transport system permease component
ELX58_RS03080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ELX58_RS03085	COG0402	S-adenosylhomocysteine deaminase activity
ELX58_RS03095	COG0737	Belongs to the 5'-nucleotidase family
ELX58_RS03110	COG1482	cell wall glycoprotein biosynthetic process
ELX58_RS03115	COG0028	Belongs to the TPP enzyme family
ELX58_RS03140	COG4975	Glucose uptake
ELX58_RS03170	COG0436	Aminotransferase
ELX58_RS03175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ELX58_RS03180	COG0527	aspartate kinase activity
ELX58_RS03185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ELX58_RS03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ELX58_RS03195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ELX58_RS03200	COG1473	amidohydrolase
ELX58_RS03205	COG2171	N-acyltransferase activity
ELX58_RS03255	COG2814	Major facilitator Superfamily
ELX58_RS03265	COG2936	dipeptidyl-peptidase activity
ELX58_RS03270	COG0823	Involved in the tonB-independent uptake of proteins
ELX58_RS03270	COG1506	peptidase
ELX58_RS03270	COG4946	Tricorn protease homolog
ELX58_RS03340	COG1959	2 iron, 2 sulfur cluster binding
ELX58_RS03345	COG0702	epimerase
ELX58_RS03365	COG4975	Glucose uptake
ELX58_RS03385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ELX58_RS03390	COG0833	amino acid
ELX58_RS03410	COG0697	spore germination
ELX58_RS03415	COG0300	oxidoreductase activity
ELX58_RS03435	COG0248	Ppx GppA phosphatase
ELX58_RS03440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ELX58_RS03445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ELX58_RS03455	COG2217	Heavy metal translocating P-type atpase
ELX58_RS03465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ELX58_RS03485	COG2814	Major facilitator Superfamily
ELX58_RS03520	COG0697	spore germination
ELX58_RS03525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ELX58_RS03575	COG4720	Psort location CytoplasmicMembrane, score
ELX58_RS03600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ELX58_RS03605	COG1113	amino acid transport
ELX58_RS03630	COG1192	Involved in chromosome partitioning
ELX58_RS03650	COG2801	Transposase and inactivated derivatives
ELX58_RS03675	COG0242	peptide deformylase activity
ELX58_RS03695	COG1012	belongs to the aldehyde dehydrogenase family
ELX58_RS03720	COG2801	Transposase and inactivated derivatives
ELX58_RS03725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ELX58_RS03735	COG0516	GMP reductase activity
ELX58_RS03735	COG0517	IMP dehydrogenase activity
ELX58_RS03785	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ELX58_RS03795	COG0584	glycerophosphoryl diester phosphodiesterase
ELX58_RS03815	COG0697	spore germination
ELX58_RS03840	COG0148	phosphopyruvate hydratase activity
ELX58_RS03855	COG0697	spore germination
ELX58_RS03875	COG1126	abc transporter atp-binding protein
ELX58_RS03880	COG0765	amino acid transport
ELX58_RS03890	COG0789	Transcriptional regulator
ELX58_RS03895	COG0174	glutamine synthetase
ELX58_RS03920	COG0572	uridine kinase
ELX58_RS03930	COG2610	gluconate transmembrane transporter activity
ELX58_RS03935	COG0561	phosphatase activity
ELX58_RS03950	COG0697	spore germination
ELX58_RS03970	COG1132	(ABC) transporter
ELX58_RS03990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ELX58_RS03995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ELX58_RS04000	COG0710	3-dehydroquinate dehydratase activity
ELX58_RS04005	COG0738	Major facilitator superfamily
ELX58_RS04010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ELX58_RS04015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ELX58_RS04020	COG0436	Aminotransferase
ELX58_RS04025	COG0287	Prephenate dehydrogenase
ELX58_RS04030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ELX58_RS04035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ELX58_RS04050	COG3118	belongs to the thioredoxin family
ELX58_RS04065	COG2094	Belongs to the DNA glycosylase MPG family
ELX58_RS04075	COG2814	Major facilitator Superfamily
ELX58_RS04115	COG1428	Deoxynucleoside kinase
ELX58_RS04165	COG1113	amino acid transport
ELX58_RS04205	COG0494	nUDIX hydrolase
ELX58_RS04215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ELX58_RS04225	COG1472	Belongs to the glycosyl hydrolase 3 family
ELX58_RS04230	COG1686	Belongs to the peptidase S11 family
ELX58_RS04240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ELX58_RS04260	COG0531	amino acid
ELX58_RS04275	COG4608	Belongs to the ABC transporter superfamily
ELX58_RS04280	COG0601	transmembrane transport
ELX58_RS04285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ELX58_RS04295	COG3001	Fructosamine kinase
ELX58_RS04300	COG2706	6-phosphogluconolactonase activity
ELX58_RS04325	COG1113	amino acid transport
ELX58_RS04330	COG0028	Belongs to the TPP enzyme family
ELX58_RS04350	COG4975	Glucose uptake
ELX58_RS04355	COG0110	maltose O-acetyltransferase activity
ELX58_RS04360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ELX58_RS04370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ELX58_RS04380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ELX58_RS04385	COG1268	BioY protein
ELX58_RS04415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ELX58_RS04425	COG0386	Belongs to the glutathione peroxidase family
ELX58_RS04465	COG0531	amino acid
ELX58_RS04470	COG0006	proline dipeptidase activity
ELX58_RS04500	COG0464	growth
ELX58_RS04505	COG0501	Belongs to the peptidase M48B family
ELX58_RS04525	COG0517	IMP dehydrogenase activity
ELX58_RS04525	COG1125	glycine betaine transport
ELX58_RS04530	COG1174	glycine betaine transport
ELX58_RS04540	COG0589	response to stress
ELX58_RS04555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ELX58_RS04575	COG0519	Catalyzes the synthesis of GMP from XMP
ELX58_RS04595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ELX58_RS04600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ELX58_RS04605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ELX58_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
ELX58_RS04615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ELX58_RS04620	COG2011	ABC-type metal ion transport system permease component
ELX58_RS04625	COG1464	Belongs to the NlpA lipoprotein family
ELX58_RS04635	COG1854	S-ribosylhomocysteine lyase activity
ELX58_RS04640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ELX58_RS04660	COG0561	phosphatase activity
ELX58_RS04665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ELX58_RS04695	COG1780	Probably involved in ribonucleotide reductase function
ELX58_RS04735	COG2252	PERMEase
ELX58_RS04740	COG4975	Glucose uptake
ELX58_RS04765	COG2814	Major facilitator Superfamily
ELX58_RS04775	COG1940	carbohydrate kinase activity
ELX58_RS04790	COG1063	alcohol dehydrogenase
ELX58_RS04800	COG0346	lactoylglutathione lyase activity
ELX58_RS04820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ELX58_RS04845	COG0561	phosphatase activity
ELX58_RS04850	COG0697	spore germination
ELX58_RS04930	COG0436	Aminotransferase
ELX58_RS04975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ELX58_RS04980	COG1704	LemA family
ELX58_RS04985	COG0501	Belongs to the peptidase M48B family
ELX58_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
ELX58_RS05025	COG0028	Belongs to the TPP enzyme family
ELX58_RS05050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ELX58_RS05055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ELX58_RS05060	COG0037	tRNA processing
ELX58_RS05060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ELX58_RS05065	COG0477	Major facilitator Superfamily
ELX58_RS05070	COG0009	L-threonylcarbamoyladenylate synthase
ELX58_RS05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
ELX58_RS05085	COG1988	membrane-bound metal-dependent
ELX58_RS05095	COG1113	amino acid transport
ELX58_RS05135	COG0776	regulation of translation
ELX58_RS05160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ELX58_RS05165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ELX58_RS05195	COG1307	EDD domain protein, DegV family
ELX58_RS05200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ELX58_RS05205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ELX58_RS05215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ELX58_RS05220	COG0564	pseudouridine synthase activity
ELX58_RS05235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ELX58_RS05240	COG0116	Belongs to the methyltransferase superfamily
ELX58_RS05250	COG3599	regulation of cell shape
ELX58_RS05255	COG4474	Belongs to the UPF0398 family
ELX58_RS05260	COG3331	DNA recombination
ELX58_RS05265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ELX58_RS05275	COG0017	Asparaginyl-tRNA synthetase
ELX58_RS05285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ELX58_RS05285	COG1199	ATP-dependent helicase activity
ELX58_RS05290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ELX58_RS05305	COG1304	FMN binding
ELX58_RS05310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ELX58_RS05310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ELX58_RS05320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ELX58_RS05335	COG4975	Glucose uptake
ELX58_RS05340	COG4975	Glucose uptake
ELX58_RS05345	COG2814	Major facilitator Superfamily
ELX58_RS05375	COG0531	amino acid
ELX58_RS05385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ELX58_RS05395	COG0531	amino acid
ELX58_RS05420	COG2249	NAD(P)H dehydrogenase (quinone) activity
ELX58_RS05430	COG0393	Putative heavy-metal-binding
ELX58_RS05440	COG1396	sequence-specific DNA binding
ELX58_RS05450	COG1131	(ABC) transporter
ELX58_RS05455	COG2252	PERMEase
ELX58_RS05495	COG0531	amino acid
ELX58_RS05510	COG0531	amino acid
ELX58_RS05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ELX58_RS05540	COG0588	phosphoglycerate mutase activity
ELX58_RS05545	COG0335	large ribosomal subunit rRNA binding
ELX58_RS05550	COG0336	Belongs to the RNA methyltransferase TrmD family
ELX58_RS05555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ELX58_RS05560	COG1837	Belongs to the UPF0109 family
ELX58_RS05565	COG0228	four-way junction DNA binding
ELX58_RS05585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ELX58_RS05590	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ELX58_RS05595	COG0552	protein localization to endoplasmic reticulum
ELX58_RS05600	COG1196	nuclear chromosome segregation
ELX58_RS05605	COG0571	ribonuclease III activity
ELX58_RS05610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ELX58_RS05615	COG0416	fatty acid biosynthetic process
ELX58_RS05620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ELX58_RS05625	COG1461	Dihydroxyacetone kinase
ELX58_RS05630	COG1302	Protein conserved in bacteria
ELX58_RS05635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ELX58_RS05640	COG1564	THIamine pyrophosphokinase
ELX58_RS05645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ELX58_RS05650	COG1162	GTPase activity
ELX58_RS05655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ELX58_RS05655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ELX58_RS05660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ELX58_RS05665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ELX58_RS05670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ELX58_RS05675	COG1758	RNA polymerase activity
ELX58_RS05685	COG0497	DNA recombination
ELX58_RS05690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ELX58_RS05700	COG1722	exodeoxyribonuclease VII activity
ELX58_RS05705	COG1570	exodeoxyribonuclease VII activity
ELX58_RS05710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ELX58_RS05715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ELX58_RS05720	COG1302	Protein conserved in bacteria
ELX58_RS05725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ELX58_RS05730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ELX58_RS05740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ELX58_RS05770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ELX58_RS05780	COG1940	carbohydrate kinase activity
ELX58_RS05790	COG0457	Tetratricopeptide repeat
ELX58_RS05790	COG0705	Rhomboid family
ELX58_RS05795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ELX58_RS05800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ELX58_RS05805	COG0768	penicillin binding
ELX58_RS05815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ELX58_RS05820	COG0572	uridine kinase
ELX58_RS05830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ELX58_RS05830	COG0072	phenylalanine-tRNA ligase activity
ELX58_RS05835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ELX58_RS05840	COG1733	regulation of RNA biosynthetic process
ELX58_RS05850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ELX58_RS05860	COG0706	membrane insertase activity
ELX58_RS05865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ELX58_RS05875	COG1323	Belongs to the UPF0348 family
ELX58_RS05880	COG0799	negative regulation of ribosome biogenesis
ELX58_RS05885	COG1713	HD superfamily hydrolase involved in NAD metabolism
ELX58_RS05890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ELX58_RS05900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ELX58_RS05905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ELX58_RS05910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ELX58_RS05915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ELX58_RS05920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ELX58_RS05925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ELX58_RS05930	COG1484	DNA-dependent DNA replication
ELX58_RS05940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ELX58_RS05945	COG0237	dephospho-CoA kinase activity
ELX58_RS05950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ELX58_RS05955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ELX58_RS05955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ELX58_RS05960	COG0670	Belongs to the BI1 family
ELX58_RS05965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ELX58_RS05970	COG1674	ftsk spoiiie
ELX58_RS05975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ELX58_RS05985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ELX58_RS05995	COG1131	(ABC) transporter
ELX58_RS06000	COG0537	adenosine 5'-monophosphoramidase activity
ELX58_RS06010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ELX58_RS06020	COG4717	serine-type aminopeptidase activity
ELX58_RS06025	COG0420	3'-5' exonuclease activity
ELX58_RS06030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ELX58_RS06035	COG0018	arginyl-trna synthetase
ELX58_RS06050	COG1780	Probably involved in ribonucleotide reductase function
ELX58_RS06075	COG0436	Aminotransferase
ELX58_RS06080	COG0436	Aminotransferase
ELX58_RS06085	COG1794	racemase activity, acting on amino acids and derivatives
ELX58_RS06100	COG0367	asparagine synthase
ELX58_RS06120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ELX58_RS06130	COG0495	leucyl-tRNA aminoacylation
ELX58_RS06135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ELX58_RS06140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ELX58_RS06145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ELX58_RS06290	COG0647	UMP catabolic process
ELX58_RS06295	COG4470	Protein conserved in bacteria
ELX58_RS06300	COG1113	amino acid transport
ELX58_RS06305	COG0827	DNA restriction-modification system
ELX58_RS06325	COG4537	Required for transformation and DNA binding
ELX58_RS06330	COG1459	type II secretion system
ELX58_RS06335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ELX58_RS06340	COG0217	transcriptional regulatory protein
ELX58_RS06345	COG1609	Transcriptional regulator
ELX58_RS06360	COG0668	transmembrane transport
ELX58_RS06365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ELX58_RS06370	COG3118	belongs to the thioredoxin family
ELX58_RS06375	COG1193	negative regulation of DNA recombination
ELX58_RS06390	COG3906	Belongs to the UPF0473 family
ELX58_RS06395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ELX58_RS06400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ELX58_RS06405	COG0513	Belongs to the DEAD box helicase family
ELX58_RS06410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ELX58_RS06415	COG1862	Preprotein translocase
ELX58_RS06420	COG2255	four-way junction helicase activity
ELX58_RS06430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ELX58_RS06435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ELX58_RS06445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ELX58_RS06450	COG1546	Belongs to the CinA family
ELX58_RS06450	COG1058	Belongs to the CinA family
ELX58_RS06455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ELX58_RS06460	COG1426	Protein conserved in bacteria
ELX58_RS06465	COG2894	cell division
ELX58_RS06480	COG1792	Involved in formation and maintenance of cell shape
ELX58_RS06485	COG1077	Cell shape determining protein MreB Mrl
ELX58_RS06490	COG0285	dihydrofolate synthase activity
ELX58_RS06495	COG0525	valine-tRNA ligase activity
ELX58_RS06500	COG0301	tRNA thio-modification
ELX58_RS06505	COG1104	cysteine desulfurase activity
ELX58_RS06510	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ELX58_RS06515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ELX58_RS06540	COG2818	Glycosylase
ELX58_RS06545	COG1181	Belongs to the D-alanine--D-alanine ligase family
ELX58_RS06555	COG1464	Belongs to the NlpA lipoprotein family
ELX58_RS06560	COG2011	ABC-type metal ion transport system permease component
ELX58_RS06565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ELX58_RS06570	COG0772	Belongs to the SEDS family
ELX58_RS06580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ELX58_RS06585	COG1077	Cell shape determining protein MreB Mrl
ELX58_RS06595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ELX58_RS06600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ELX58_RS06605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ELX58_RS06615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ELX58_RS06620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ELX58_RS06625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ELX58_RS06630	COG0356	it plays a direct role in the translocation of protons across the membrane
ELX58_RS06635	COG2890	protein-(glutamine-N5) methyltransferase activity
ELX58_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ELX58_RS06665	COG3158	transport of potassium into the cell
ELX58_RS06675	COG1134	teichoic acid transport
ELX58_RS06680	COG3942	CHAP domain
ELX58_RS06680	COG1705	Flagellar rod assembly protein muramidase FlgJ
ELX58_RS06685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ELX58_RS06690	COG4856	YbbR-like protein
ELX58_RS06705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ELX58_RS06720	COG0802	atpase or kinase
ELX58_RS06725	COG0280	phosphate acetyltransferase
ELX58_RS06730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ELX58_RS06735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ELX58_RS06740	COG0557	exoribonuclease II activity
ELX58_RS06755	COG0149	triose-phosphate isomerase activity
ELX58_RS06760	COG0126	phosphoglycerate kinase activity
ELX58_RS06775	COG0740	serine-type endopeptidase activity
ELX58_RS06780	COG1481	regulation of sporulation
ELX58_RS06785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ELX58_RS06790	COG1660	Displays ATPase and GTPase activities
ELX58_RS06795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ELX58_RS06800	COG0556	nucleotide-excision repair
ELX58_RS06805	COG0492	ferredoxin-NADP+ reductase activity
ELX58_RS06815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ELX58_RS06820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ELX58_RS06825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ELX58_RS06840	COG0653	protein targeting
ELX58_RS06850	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ELX58_RS06855	COG1739	Uncharacterized protein family UPF0029
ELX58_RS06860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ELX58_RS06865	COG0459	protein refolding
ELX58_RS06875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ELX58_RS06880	COG0488	(ABC) transporter
ELX58_RS06885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ELX58_RS06890	COG1126	abc transporter atp-binding protein
ELX58_RS06895	COG0765	amino acid transport
ELX58_RS06900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ELX58_RS06905	COG1214	PFAM Peptidase M22, glycoprotease
ELX58_RS06915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ELX58_RS06920	COG4467	Involved in initiation control of chromosome replication
ELX58_RS06925	COG0470	DNA polymerase III
ELX58_RS06930	COG3870	Protein conserved in bacteria
ELX58_RS06935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ELX58_RS06940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ELX58_RS06950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ELX58_RS06965	COG2813	Specifically methylates the guanine in position
ELX58_RS06970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ELX58_RS06975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ELX58_RS06980	COG0392	lysyltransferase activity
ELX58_RS06980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ELX58_RS06985	COG0222	ribosome binding
ELX58_RS06990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ELX58_RS06995	COG0081	regulation of translation
ELX58_RS07000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ELX58_RS07005	COG0250	Participates in transcription elongation, termination and antitermination
ELX58_RS07030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ELX58_RS07035	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ELX58_RS07040	COG0215	cysteine-tRNA ligase activity
ELX58_RS07045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ELX58_RS07050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ELX58_RS07055	COG0756	dUTP diphosphatase activity
ELX58_RS07065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ELX58_RS07080	COG0588	phosphoglycerate mutase activity
ELX58_RS07085	COG1316	TRANSCRIPTIONal
ELX58_RS07125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ELX58_RS07130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ELX58_RS07135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ELX58_RS07150	COG0037	tRNA processing
ELX58_RS07155	COG1098	S1 RNA binding domain
ELX58_RS07165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ELX58_RS07170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ELX58_RS07175	COG0193	aminoacyl-tRNA hydrolase activity
ELX58_RS07180	COG2337	Toxic component of a toxin-antitoxin (TA) module
ELX58_RS07185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ELX58_RS07190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ELX58_RS07200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ELX58_RS07205	COG0254	rRNA binding
ELX58_RS07210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ELX58_RS07215	COG0504	CTP synthase activity
ELX58_RS07235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ELX58_RS07240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ELX58_RS07245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ELX58_RS07255	COG0084	hydrolase, TatD family'
ELX58_RS07260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ELX58_RS07260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ELX58_RS07285	COG3973	AAA domain
ELX58_RS07295	COG4975	Glucose uptake
ELX58_RS07300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ELX58_RS07325	COG0656	L-ascorbic acid biosynthetic process
ELX58_RS07375	COG3118	belongs to the thioredoxin family
ELX58_RS07380	COG0861	Integral membrane protein TerC family
ELX58_RS07385	COG1705	Flagellar rod assembly protein muramidase FlgJ
ELX58_RS07395	COG3103	Sh3 type 3 domain protein
ELX58_RS07395	COG1388	LysM domain
ELX58_RS07395	COG0791	NLP P60 protein
ELX58_RS07400	COG0406	alpha-ribazole phosphatase activity
ELX58_RS07410	COG1368	sulfuric ester hydrolase activity
ELX58_RS07415	COG0492	ferredoxin-NADP+ reductase activity
ELX58_RS07425	COG1393	Belongs to the ArsC family
ELX58_RS07430	COG0737	Belongs to the 5'-nucleotidase family
ELX58_RS07440	COG1418	mRNA catabolic process
ELX58_RS07470	COG0564	pseudouridine synthase activity
ELX58_RS07475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ELX58_RS07480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ELX58_RS07485	COG1418	mRNA catabolic process
ELX58_RS07500	COG0656	L-ascorbic acid biosynthetic process
ELX58_RS07505	COG1301	dicarboxylic acid transport
ELX58_RS07515	COG0004	ammonium transporteR
ELX58_RS07525	COG0071	Belongs to the small heat shock protein (HSP20) family
ELX58_RS07535	COG1253	flavin adenine dinucleotide binding
ELX58_RS07555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ELX58_RS07565	COG1126	abc transporter atp-binding protein
ELX58_RS07570	COG0765	amino acid transport
ELX58_RS07585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ELX58_RS07600	COG2132	Multicopper oxidase
ELX58_RS07605	COG2132	Multicopper oxidase
ELX58_RS07665	COG1940	carbohydrate kinase activity
ELX58_RS07705	COG1121	(ABC) transporter
ELX58_RS07760	COG0445	tRNA wobble uridine modification
ELX58_RS07770	COG1847	R3H domain protein
ELX58_RS07775	COG0706	membrane insertase activity
ELX58_RS07780	COG0594	ribonuclease P activity
ELX58_RS07785	COG0230	Belongs to the bacterial ribosomal protein bL34 family