locus-tag	class	description
C9423_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9423_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C9423_RS00015	COG0594	ribonuclease P activity
C9423_RS00020	COG0706	membrane insertase activity
C9423_RS00025	COG1847	R3H domain protein
C9423_RS00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C9423_RS00045	COG0445	tRNA wobble uridine modification
C9423_RS00050	COG0357	Ribosomal RNA small subunit methyltransferase G
C9423_RS00055	COG1192	Involved in chromosome partitioning
C9423_RS00060	COG1475	DNA binding
C9423_RS00065	COG4481	Protein conserved in bacteria
C9423_RS00070	COG0012	GTP binding
C9423_RS00080	COG0516	GMP reductase activity
C9423_RS00080	COG0517	IMP dehydrogenase activity
C9423_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C9423_RS00165	COG4463	regulation of RNA biosynthetic process
C9423_RS00170	COG0542	response to heat
C9423_RS00175	COG0826	peptidase U32
C9423_RS00180	COG0826	peptidase U32
C9423_RS00280	COG4939	FMN-binding domain protein
C9423_RS00300	COG0142	geranyltranstransferase activity
C9423_RS00320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C9423_RS00320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C9423_RS00330	COG4120	Belongs to the binding-protein-dependent transport system permease family
C9423_RS00350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C9423_RS00355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C9423_RS00365	COG1070	Carbohydrate kinase
C9423_RS00370	COG0783	Belongs to the Dps family
C9423_RS00375	COG0165	Argininosuccinate lyase
C9423_RS00380	COG0137	argininosuccinate synthase activity
C9423_RS00385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C9423_RS00390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C9423_RS00405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C9423_RS00410	COG1131	(ABC) transporter
C9423_RS00415	COG0842	Transport permease protein
C9423_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9423_RS00430	COG1233	COG1233 Phytoene dehydrogenase and related
C9423_RS00435	COG1562	ergosterol biosynthetic process
C9423_RS00455	COG0702	epimerase
C9423_RS00465	COG1388	LysM domain
C9423_RS00465	COG1705	Flagellar rod assembly protein muramidase FlgJ
C9423_RS00480	COG2814	Major facilitator Superfamily
C9423_RS00495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C9423_RS00500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C9423_RS00505	COG0756	dUTP diphosphatase activity
C9423_RS00515	COG4956	integral membrane protein (PIN domain superfamily)
C9423_RS00520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9423_RS00525	COG1045	serine acetyltransferase
C9423_RS00530	COG0215	cysteine-tRNA ligase activity
C9423_RS00535	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C9423_RS00545	COG3688	RNA-binding protein containing a PIN domain
C9423_RS00560	COG4466	Protein conserved in bacteria
C9423_RS00565	COG2153	protein acetylation
C9423_RS00570	COG1970	mechanosensitive ion channel activity
C9423_RS00575	COG0612	Peptidase, M16
C9423_RS00580	COG0612	Peptidase, M16
C9423_RS00585	COG1426	Protein conserved in bacteria
C9423_RS00590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C9423_RS00595	COG1058	Belongs to the CinA family
C9423_RS00595	COG1546	Belongs to the CinA family
C9423_RS00600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C9423_RS00605	COG1418	mRNA catabolic process
C9423_RS00610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C9423_RS00615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C9423_RS00615	COG0392	lysyltransferase activity
C9423_RS00625	COG3443	Belongs to the bacterial solute-binding protein 9 family
C9423_RS00625	COG0803	Belongs to the bacterial solute-binding protein 9 family
C9423_RS00630	COG1121	(ABC) transporter
C9423_RS00635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9423_RS00640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9423_RS00650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9423_RS00655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9423_RS00680	COG1561	YicC-like family, N-terminal region
C9423_RS00690	COG0194	GDP metabolic process
C9423_RS00695	COG1758	RNA polymerase activity
C9423_RS00700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C9423_RS00705	COG0242	peptide deformylase activity
C9423_RS00710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C9423_RS00715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C9423_RS00715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9423_RS00725	COG0515	serine threonine protein kinase
C9423_RS00725	COG2815	serine threonine protein kinase
C9423_RS00730	COG1162	GTPase activity
C9423_RS00735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C9423_RS00745	COG1792	Involved in formation and maintenance of cell shape
C9423_RS00775	COG0217	transcriptional regulatory protein
C9423_RS00785	COG1376	ErfK ybiS ycfS ynhG family protein
C9423_RS00790	COG0039	L-malate dehydrogenase activity
C9423_RS00795	COG0193	aminoacyl-tRNA hydrolase activity
C9423_RS00800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C9423_RS00805	COG2244	polysaccharide biosynthetic process
C9423_RS00810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C9423_RS00820	COG1098	S1 RNA binding domain
C9423_RS00825	COG0037	tRNA processing
C9423_RS00830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C9423_RS00835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9423_RS00840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C9423_RS00845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9423_RS00850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C9423_RS01000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C9423_RS01005	COG0477	Major facilitator Superfamily
C9423_RS01015	COG1607	acyl-coa hydrolase
C9423_RS01030	COG1132	(ABC) transporter
C9423_RS01035	COG1132	(ABC) transporter
C9423_RS01045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C9423_RS01050	COG1242	4 iron, 4 sulfur cluster binding
C9423_RS01055	COG0671	phosphoesterase, PA-phosphatase related
C9423_RS01060	COG1388	LysM domain
C9423_RS01060	COG1705	Flagellar rod assembly protein muramidase FlgJ
C9423_RS01065	COG0495	leucyl-tRNA aminoacylation
C9423_RS01085	COG3711	transcriptional antiterminator
C9423_RS01085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS01090	COG1447	Phosphotransferase system cellobiose-specific component IIA
C9423_RS01100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS01105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C9423_RS01110	COG2244	polysaccharide biosynthetic process
C9423_RS01115	COG1187	pseudouridine synthase activity
C9423_RS01120	COG1175	transmembrane transport
C9423_RS01125	COG0395	ABC-type sugar transport system, permease component
C9423_RS01130	COG1653	transport
C9423_RS01140	COG2972	Histidine kinase
C9423_RS01145	COG4753	response regulator
C9423_RS01145	COG2207	Transcriptional regulator
C9423_RS01155	COG0101	tRNA pseudouridine synthase activity
C9423_RS01170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C9423_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
C9423_RS01180	COG0800	Aldolase
C9423_RS01190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C9423_RS01195	COG0667	Aldo Keto reductase
C9423_RS01200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS01205	COG1447	Phosphotransferase system cellobiose-specific component IIA
C9423_RS01210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS01230	COG1063	alcohol dehydrogenase
C9423_RS01260	COG1518	maintenance of DNA repeat elements
C9423_RS01265	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C9423_RS01300	COG1113	amino acid transport
C9423_RS01305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS01345	COG2610	gluconate transmembrane transporter activity
C9423_RS01350	COG1929	Belongs to the glycerate kinase type-1 family
C9423_RS01355	COG3835	regulator
C9423_RS01370	COG1105	Belongs to the carbohydrate kinase PfkB family
C9423_RS01375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS01375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS01375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS01380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS01380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS01380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS01385	COG3684	Belongs to the aldolase LacD family
C9423_RS01400	COG3328	transposase activity
C9423_RS01415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS01420	COG3414	Phosphotransferase system galactitol-specific IIB component
C9423_RS01425	COG3775	system Galactitol-specific IIC component
C9423_RS01450	COG0583	DNA-binding transcription factor activity
C9423_RS01455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C9423_RS01465	COG3052	prosthetic group binding
C9423_RS01500	COG1051	belongs to the nudix hydrolase family
C9423_RS01505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C9423_RS01510	COG0512	Glutamine amidotransferase of anthranilate synthase
C9423_RS01515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9423_RS01520	COG0134	indole-3-glycerol-phosphate synthase activity
C9423_RS01525	COG0135	phosphoribosylanthranilate isomerase activity
C9423_RS01530	COG0133	tryptophan synthase activity
C9423_RS01540	COG1846	Transcriptional regulator
C9423_RS01565	COG2252	PERMEase
C9423_RS01570	COG0366	Alpha amylase catalytic
C9423_RS01580	COG1902	pentaerythritol trinitrate reductase activity
C9423_RS01590	COG0656	L-ascorbic acid biosynthetic process
C9423_RS01595	COG1136	(ABC) transporter
C9423_RS01595	COG0577	efflux transmembrane transporter activity
C9423_RS01595	COG1136	(ABC) transporter
C9423_RS01595	COG0577	efflux transmembrane transporter activity
C9423_RS01610	COG0583	DNA-binding transcription factor activity
C9423_RS01615	COG1811	Na channel or pump
C9423_RS01655	COG1136	(ABC) transporter
C9423_RS01665	COG1705	Flagellar rod assembly protein muramidase FlgJ
C9423_RS01665	COG3942	CHAP domain
C9423_RS01670	COG1609	Transcriptional regulator
C9423_RS01700	COG0628	permease
C9423_RS01730	COG3279	Response regulator of the LytR AlgR family
C9423_RS01750	COG1428	Deoxynucleoside kinase
C9423_RS01760	COG0210	DNA helicase
C9423_RS01765	COG1393	Belongs to the ArsC family
C9423_RS01790	COG0386	Belongs to the glutathione peroxidase family
C9423_RS01800	COG0626	cystathionine gamma-synthase activity
C9423_RS01805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C9423_RS01810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C9423_RS01815	COG1272	protein, Hemolysin III
C9423_RS01825	COG0019	diaminopimelate decarboxylase activity
C9423_RS01830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C9423_RS01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C9423_RS01840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C9423_RS01845	COG2171	N-acyltransferase activity
C9423_RS01850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C9423_RS01855	COG0527	aspartate kinase activity
C9423_RS01860	COG1473	amidohydrolase
C9423_RS01865	COG0436	Aminotransferase
C9423_RS01875	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS01880	COG1917	Cupin 2, conserved barrel domain protein
C9423_RS01880	COG2207	Transcriptional regulator
C9423_RS01895	COG2211	Major facilitator Superfamily
C9423_RS01930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9423_RS01935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C9423_RS01940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C9423_RS01945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C9423_RS01950	COG0287	Prephenate dehydrogenase
C9423_RS01960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C9423_RS01965	COG0077	Prephenate dehydratase
C9423_RS01970	COG0693	protein deglycase activity
C9423_RS01985	COG2357	RelA SpoT domain protein
C9423_RS01990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C9423_RS01995	COG0564	pseudouridine synthase activity
C9423_RS02000	COG2239	Acts as a magnesium transporter
C9423_RS02005	COG3142	Participates in the control of copper homeostasis
C9423_RS02015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C9423_RS02025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9423_RS02045	COG1597	lipid kinase activity
C9423_RS02060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C9423_RS02065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C9423_RS02070	COG0250	Participates in transcription elongation, termination and antitermination
C9423_RS02080	COG1304	FMN binding
C9423_RS02085	COG1760	l-serine dehydratase
C9423_RS02090	COG1760	l-serine dehydratase
C9423_RS02095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C9423_RS02100	COG0081	regulation of translation
C9423_RS02105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C9423_RS02110	COG0222	ribosome binding
C9423_RS02120	COG2814	Major facilitator Superfamily
C9423_RS02125	COG0488	(ABC) transporter
C9423_RS02130	COG0363	glucosamine-6-phosphate deaminase activity
C9423_RS02135	COG1285	pathogenesis
C9423_RS02140	COG0628	permease
C9423_RS02150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9423_RS02155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C9423_RS02185	COG3448	diguanylate cyclase activity
C9423_RS02185	COG4175	Glycine betaine
C9423_RS02195	COG0561	phosphatase activity
C9423_RS02210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9423_RS02365	COG0740	serine-type endopeptidase activity
C9423_RS02445	COG3942	CHAP domain
C9423_RS02445	COG1388	LysM domain
C9423_RS02485	COG1307	EDD domain protein, DegV family
C9423_RS02490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C9423_RS02495	COG0745	RESPONSE REGULATOR receiver
C9423_RS02500	COG5002	protein histidine kinase activity
C9423_RS02515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C9423_RS02535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C9423_RS02540	COG0459	protein refolding
C9423_RS02545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS02570	COG1609	Transcriptional regulator
C9423_RS02575	COG0789	Transcriptional regulator
C9423_RS02585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C9423_RS02595	COG1368	sulfuric ester hydrolase activity
C9423_RS02605	COG2357	RelA SpoT domain protein
C9423_RS02670	COG0482	sulfurtransferase activity
C9423_RS02675	COG0789	Transcriptional regulator
C9423_RS02680	COG0656	L-ascorbic acid biosynthetic process
C9423_RS02685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C9423_RS02730	COG0765	amino acid transport
C9423_RS02735	COG1126	abc transporter atp-binding protein
C9423_RS02740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9423_RS02745	COG2723	6-phospho-beta-galactosidase activity
C9423_RS02750	COG1280	lysine exporter protein (LysE YggA)
C9423_RS02750	COG1674	ftsk spoiiie
C9423_RS02755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9423_RS02760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C9423_RS02770	COG4166	transmembrane transport
C9423_RS02780	COG0601	transmembrane transport
C9423_RS02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C9423_RS02790	COG0444	Belongs to the ABC transporter superfamily
C9423_RS02795	COG4608	Belongs to the ABC transporter superfamily
C9423_RS02800	COG0675	Transposase, IS605 OrfB family
C9423_RS02815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9423_RS02815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9423_RS02840	COG0531	amino acid
C9423_RS02845	COG0084	hydrolase, TatD family'
C9423_RS02850	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C9423_RS02855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9423_RS02870	COG3842	ATPase activity
C9423_RS02875	COG1803	Methylglyoxal synthase
C9423_RS02885	COG1132	(ABC) transporter
C9423_RS02890	COG1132	(ABC) transporter
C9423_RS02900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS02900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS02910	COG3715	PTS system
C9423_RS02915	COG3716	PTS system mannose fructose sorbose family IID component
C9423_RS02920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9423_RS02930	COG3397	chitin binding
C9423_RS02940	COG3469	chitinase activity
C9423_RS02945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C9423_RS02970	COG4821	SIS domain
C9423_RS02975	COG1288	antiporter activity
C9423_RS02980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C9423_RS02990	COG1136	(ABC) transporter
C9423_RS02995	COG0577	efflux transmembrane transporter activity
C9423_RS03010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C9423_RS03015	COG4109	DRTGG domain
C9423_RS03020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C9423_RS03025	COG2824	Alkylphosphonate utilization operon protein PhnA
C9423_RS03030	COG2738	Putative neutral zinc metallopeptidase
C9423_RS03055	COG1104	cysteine desulfurase activity
C9423_RS03060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C9423_RS03070	COG0157	Belongs to the NadC ModD family
C9423_RS03090	COG0590	tRNA wobble adenosine to inosine editing
C9423_RS03100	COG0737	Belongs to the 5'-nucleotidase family
C9423_RS03105	COG4470	Protein conserved in bacteria
C9423_RS03110	COG0647	UMP catabolic process
C9423_RS03120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C9423_RS03125	COG0492	ferredoxin-NADP+ reductase activity
C9423_RS03135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C9423_RS03140	COG1098	S1 RNA binding domain
C9423_RS03225	COG3579	cysteine-type endopeptidase activity
C9423_RS03245	COG1801	Protein of unknown function DUF72
C9423_RS03260	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C9423_RS03265	COG1104	cysteine desulfurase activity
C9423_RS03270	COG0301	tRNA thio-modification
C9423_RS03275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C9423_RS03280	COG0525	valine-tRNA ligase activity
C9423_RS03295	COG0285	dihydrofolate synthase activity
C9423_RS03305	COG2003	Belongs to the UPF0758 family
C9423_RS03310	COG1278	Cold shock
C9423_RS03320	COG5503	Protein of unknown function (DUF1447)
C9423_RS03345	COG0740	serine-type endopeptidase activity
C9423_RS03355	COG0584	glycerophosphoryl diester phosphodiesterase
C9423_RS03360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C9423_RS03365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C9423_RS03370	COG0789	Transcriptional regulator
C9423_RS03375	COG0174	glutamine synthetase
C9423_RS03380	COG0504	CTP synthase activity
C9423_RS03395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C9423_RS03400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C9423_RS03405	COG0254	rRNA binding
C9423_RS03475	COG1349	DNA-binding transcription factor activity
C9423_RS03490	COG2814	Major facilitator Superfamily
C9423_RS03500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9423_RS03530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS03535	COG1737	Transcriptional regulator
C9423_RS03555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C9423_RS03560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C9423_RS03565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C9423_RS03570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C9423_RS03575	COG3870	Protein conserved in bacteria
C9423_RS03580	COG0470	DNA polymerase III
C9423_RS03585	COG1774	PSP1 C-terminal conserved region
C9423_RS03590	COG4467	Involved in initiation control of chromosome replication
C9423_RS03605	COG0701	Predicted permease
C9423_RS03610	COG3689	TIGRFAM TIGR03943 family protein
C9423_RS03620	COG1131	(ABC) transporter
C9423_RS03650	COG4472	Bacterial protein of unknown function (DUF965)
C9423_RS03655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C9423_RS03660	COG3906	Belongs to the UPF0473 family
C9423_RS03665	COG0640	Transcriptional regulator
C9423_RS03675	COG2814	Major facilitator Superfamily
C9423_RS03685	COG2814	Major facilitator Superfamily
C9423_RS03720	COG0281	malic enzyme
C9423_RS03725	COG1304	FMN binding
C9423_RS03730	COG1349	DNA-binding transcription factor activity
C9423_RS03740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS03745	COG3037	sugar-specific permease SgaT UlaA
C9423_RS03760	COG3623	hexulose-6-phosphate isomerase
C9423_RS03765	COG0235	Class ii aldolase
C9423_RS03780	COG1136	(ABC) transporter
C9423_RS03785	COG1309	transcriptional regulator
C9423_RS03790	COG3103	Sh3 type 3 domain protein
C9423_RS03790	COG4991	sh3 domain protein
C9423_RS03790	COG0860	N-Acetylmuramoyl-L-alanine amidase
C9423_RS03800	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C9423_RS03815	COG1193	negative regulation of DNA recombination
C9423_RS03820	COG3118	belongs to the thioredoxin family
C9423_RS03825	COG0322	excinuclease ABC activity
C9423_RS03830	COG4152	abc transporter atp-binding protein
C9423_RS03840	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C9423_RS03845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C9423_RS03855	COG1269	ATP hydrolysis coupled proton transport
C9423_RS03860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C9423_RS03865	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C9423_RS03870	COG1527	subunit (C
C9423_RS03875	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
C9423_RS03880	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C9423_RS03885	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C9423_RS03890	COG1394	ATPase activity, coupled to movement of substances
C9423_RS03895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C9423_RS03900	COG0346	lactoylglutathione lyase activity
C9423_RS03905	COG0494	nUDIX hydrolase
C9423_RS03910	COG0561	phosphatase activity
C9423_RS03915	COG1078	dGTPase activity
C9423_RS03920	COG0095	Lipoate-protein ligase
C9423_RS03935	COG1595	DNA-templated transcription, initiation
C9423_RS03955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C9423_RS03965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS03970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS03990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C9423_RS03995	COG2390	Transcriptional regulator
C9423_RS04005	COG0126	phosphoglycerate kinase activity
C9423_RS04010	COG0149	triose-phosphate isomerase activity
C9423_RS04020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C9423_RS04040	COG1957	nucleoside hydrolase
C9423_RS04050	COG2388	GCN5-related N-acetyl-transferase
C9423_RS04055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C9423_RS04065	COG0557	exoribonuclease II activity
C9423_RS04070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C9423_RS04080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C9423_RS04085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C9423_RS04090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C9423_RS04095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C9423_RS04100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C9423_RS04105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C9423_RS04110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C9423_RS04120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C9423_RS04130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C9423_RS04160	COG1309	transcriptional regulator
C9423_RS04170	COG2188	Transcriptional regulator
C9423_RS04175	COG1739	Uncharacterized protein family UPF0029
C9423_RS04185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS04190	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C9423_RS04205	COG0653	protein targeting
C9423_RS04215	COG2884	Cell division ATP-binding protein ftsE
C9423_RS04220	COG2177	Part of the ABC transporter FtsEX involved in
C9423_RS04225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9423_RS04230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9423_RS04235	COG0573	inorganic phosphate transmembrane transporter activity
C9423_RS04240	COG0581	inorganic phosphate transmembrane transporter activity
C9423_RS04245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C9423_RS04250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C9423_RS04255	COG0704	Plays a role in the regulation of phosphate uptake
C9423_RS04270	COG1950	PFAM Membrane protein of
C9423_RS04275	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C9423_RS04280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C9423_RS04285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C9423_RS04290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C9423_RS04300	COG4980	gas vesicle protein
C9423_RS04310	COG0006	proline dipeptidase activity
C9423_RS04315	COG1609	Transcriptional regulator
C9423_RS04340	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C9423_RS04350	COG3763	UPF0154 protein
C9423_RS04355	COG1132	(ABC) transporter
C9423_RS04360	COG1132	(ABC) transporter
C9423_RS04370	COG0577	efflux transmembrane transporter activity
C9423_RS04370	COG1136	(ABC) transporter
C9423_RS04380	COG3711	transcriptional antiterminator
C9423_RS04390	COG1737	Transcriptional regulator
C9423_RS04395	COG1486	melibiose metabolic process
C9423_RS04400	COG2723	6-phospho-beta-galactosidase activity
C9423_RS04405	COG0492	ferredoxin-NADP+ reductase activity
C9423_RS04410	COG0778	Nitroreductase
C9423_RS04415	COG1309	transcriptional regulator
C9423_RS04420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9423_RS04425	COG0640	Transcriptional regulator
C9423_RS04430	COG0640	Transcriptional regulator
C9423_RS04480	COG0604	alcohol dehydrogenase
C9423_RS04485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C9423_RS04490	COG0735	belongs to the Fur family
C9423_RS04495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C9423_RS04500	COG1610	YqeY-like protein
C9423_RS04505	COG1114	Component of the transport system for branched-chain amino acids
C9423_RS04510	COG1702	phosphate starvation-inducible protein PhoH
C9423_RS04520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C9423_RS04525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C9423_RS04530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C9423_RS04535	COG1381	Involved in DNA repair and RecF pathway recombination
C9423_RS04540	COG0752	glycyl-tRNA synthetase alpha subunit
C9423_RS04545	COG0751	glycine-tRNA ligase activity
C9423_RS04555	COG2188	Transcriptional regulator
C9423_RS04560	COG2222	sugar isomerase
C9423_RS04565	COG3684	Belongs to the aldolase LacD family
C9423_RS04570	COG1105	Belongs to the carbohydrate kinase PfkB family
C9423_RS04580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS04585	COG3715	PTS system
C9423_RS04590	COG3716	PTS system mannose fructose sorbose family IID component
C9423_RS04600	COG0706	membrane insertase activity
C9423_RS04605	COG0371	Dehydrogenase
C9423_RS04610	COG0765	amino acid transport
C9423_RS04620	COG0436	Aminotransferase
C9423_RS04625	COG1254	Belongs to the acylphosphatase family
C9423_RS04630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9423_RS04645	COG0038	chloride channel
C9423_RS04675	COG1686	Belongs to the peptidase S11 family
C9423_RS04690	COG1278	Cold shock
C9423_RS04695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C9423_RS04695	COG1199	ATP-dependent helicase activity
C9423_RS04705	COG0436	Aminotransferase
C9423_RS04710	COG0017	Asparaginyl-tRNA synthetase
C9423_RS04725	COG2217	Heavy metal translocating P-type atpase
C9423_RS04730	COG0531	amino acid
C9423_RS04740	COG3682	Transcriptional regulator
C9423_RS04745	COG2608	mercury ion transmembrane transporter activity
C9423_RS04750	COG2217	Heavy metal translocating P-type atpase
C9423_RS04755	COG2217	Heavy metal translocating P-type atpase
C9423_RS04760	COG1305	Transglutaminase-like
C9423_RS04770	COG0714	Associated with various cellular activities
C9423_RS04795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9423_RS04800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS04810	COG5002	protein histidine kinase activity
C9423_RS04815	COG0745	RESPONSE REGULATOR receiver
C9423_RS04820	COG1683	Conserved Protein
C9423_RS04825	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C9423_RS04830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C9423_RS04845	COG0431	NADPH-dependent FMN reductase
C9423_RS04865	COG4509	Sortase family
C9423_RS04875	COG0228	four-way junction DNA binding
C9423_RS04880	COG1837	Belongs to the UPF0109 family
C9423_RS04890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C9423_RS04895	COG0336	Belongs to the RNA methyltransferase TrmD family
C9423_RS04900	COG0335	large ribosomal subunit rRNA binding
C9423_RS04915	COG0626	cystathionine gamma-synthase activity
C9423_RS04925	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS04935	COG2964	Protein conserved in bacteria
C9423_RS04940	COG1247	-acetyltransferase
C9423_RS04950	COG0028	Belongs to the TPP enzyme family
C9423_RS04955	COG3527	Alpha-acetolactate decarboxylase
C9423_RS04960	COG1956	GAF domain-containing protein
C9423_RS04970	COG1846	Transcriptional regulator
C9423_RS04975	COG0778	Nitroreductase
C9423_RS05000	COG4720	Psort location CytoplasmicMembrane, score
C9423_RS05005	COG1122	ATPase activity
C9423_RS05010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C9423_RS05090	COG1061	Type III restriction enzyme res subunit
C9423_RS05250	COG0228	four-way junction DNA binding
C9423_RS05305	COG1388	LysM domain
C9423_RS05305	COG3942	CHAP domain
C9423_RS05360	COG5002	protein histidine kinase activity
C9423_RS05360	COG3850	Histidine kinase
C9423_RS05365	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C9423_RS05375	COG1368	sulfuric ester hydrolase activity
C9423_RS05380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C9423_RS05385	COG0710	3-dehydroquinate dehydratase activity
C9423_RS05390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C9423_RS05395	COG2081	HI0933 family
C9423_RS05400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C9423_RS05405	COG0166	Belongs to the GPI family
C9423_RS05435	COG0584	glycerophosphoryl diester phosphodiesterase
C9423_RS05440	COG0398	Pfam SNARE associated Golgi protein
C9423_RS05445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C9423_RS05455	COG4221	oxidoreductase activity
C9423_RS05470	COG1309	transcriptional regulator
C9423_RS05485	COG0367	asparagine synthase
C9423_RS05490	COG4876	unkown
C9423_RS05495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C9423_RS05510	COG1120	ATPase activity
C9423_RS05515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C9423_RS05520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C9423_RS05525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C9423_RS05540	COG1940	carbohydrate kinase activity
C9423_RS05545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C9423_RS05555	COG3189	MarR family transcriptional regulator
C9423_RS05570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C9423_RS05575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C9423_RS05580	COG1609	Transcriptional regulator
C9423_RS05585	COG1214	PFAM Peptidase M22, glycoprotease
C9423_RS05595	COG0456	acetyltransferase
C9423_RS05600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C9423_RS05610	COG3764	Sortase (surface protein transpeptidase)
C9423_RS05620	COG3944	biosynthesis protein
C9423_RS05625	COG0489	protein tyrosine kinase activity
C9423_RS05635	COG2235	arginine
C9423_RS05650	COG0018	arginyl-trna synthetase
C9423_RS05655	COG1438	arginine binding
C9423_RS05660	COG0052	Belongs to the universal ribosomal protein uS2 family
C9423_RS05665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C9423_RS05670	COG0528	UMP kinase activity
C9423_RS05675	COG0233	cytoplasmic translational termination
C9423_RS05680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C9423_RS05685	COG4589	Belongs to the CDS family
C9423_RS05690	COG0750	zinc metalloprotease
C9423_RS05695	COG0442	prolyl-tRNA aminoacylation
C9423_RS05705	COG0779	Required for maturation of 30S ribosomal subunits
C9423_RS05710	COG0195	Participates in both transcription termination and antitermination
C9423_RS05715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C9423_RS05730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C9423_RS05735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C9423_RS05740	COG0196	riboflavin kinase activity
C9423_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
C9423_RS05760	COG1114	Component of the transport system for branched-chain amino acids
C9423_RS05880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9423_RS05885	COG1420	regulation of RNA biosynthetic process
C9423_RS05890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C9423_RS05895	COG0443	Heat shock 70 kDa protein
C9423_RS05900	COG0484	heat shock protein binding
C9423_RS05905	COG1126	abc transporter atp-binding protein
C9423_RS05910	COG0765	amino acid transport
C9423_RS05915	COG0556	nucleotide-excision repair
C9423_RS05920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C9423_RS05930	COG1794	racemase activity, acting on amino acids and derivatives
C9423_RS05935	COG1660	Displays ATPase and GTPase activities
C9423_RS05945	COG1481	regulation of sporulation
C9423_RS05985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9423_RS06000	COG1714	RDD family
C9423_RS06010	COG0544	peptidyl-prolyl cis-trans isomerase activity
C9423_RS06015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C9423_RS06020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C9423_RS06035	COG1349	DNA-binding transcription factor activity
C9423_RS06040	COG1105	Belongs to the carbohydrate kinase PfkB family
C9423_RS06045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS06045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS06045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS06065	COG0210	DNA helicase
C9423_RS06070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C9423_RS06075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9423_RS06080	COG0154	amidase activity
C9423_RS06085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9423_RS06090	COG1597	lipid kinase activity
C9423_RS06095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C9423_RS06100	COG1609	Transcriptional regulator
C9423_RS06105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS06120	COG1874	Beta-galactosidase
C9423_RS06160	COG0411	ABC transporter
C9423_RS06170	COG0516	GMP reductase activity
C9423_RS06170	COG0517	IMP dehydrogenase activity
C9423_RS06210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C9423_RS06215	COG1609	Transcriptional regulator
C9423_RS06230	COG3250	beta-galactosidase activity
C9423_RS06235	COG2972	Histidine kinase
C9423_RS06240	COG2207	Transcriptional regulator
C9423_RS06240	COG4753	response regulator
C9423_RS06285	COG0588	phosphoglycerate mutase activity
C9423_RS06300	COG1823	symporter activity
C9423_RS06310	COG1054	Belongs to the UPF0176 family
C9423_RS06315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C9423_RS06320	COG2183	response to ionizing radiation
C9423_RS06325	COG3091	SprT-like family
C9423_RS06330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C9423_RS06335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9423_RS06340	COG3402	PFAM membrane-flanked domain
C9423_RS06360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C9423_RS06360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C9423_RS06365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C9423_RS06370	COG0237	dephospho-CoA kinase activity
C9423_RS06380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C9423_RS06390	COG1484	DNA-dependent DNA replication
C9423_RS06405	COG2384	SAM-dependent methyltransferase
C9423_RS06410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C9423_RS06415	COG2195	Cleaves the N-terminal amino acid of tripeptides
C9423_RS06420	COG1597	lipid kinase activity
C9423_RS06435	COG0542	response to heat
C9423_RS06455	COG0481	GTPase activity
C9423_RS06485	COG1278	Cold shock
C9423_RS06500	COG1396	sequence-specific DNA binding
C9423_RS06525	COG0561	phosphatase activity
C9423_RS06530	COG1442	glycosyl transferase family 8
C9423_RS06535	COG1442	glycosyl transferase family 8
C9423_RS06610	COG3655	Transcriptional regulator
C9423_RS06635	COG2261	transglycosylase associated protein
C9423_RS06660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C9423_RS06680	COG0768	penicillin binding
C9423_RS06690	COG1846	Transcriptional regulator
C9423_RS06710	COG3634	alkyl hydroperoxide reductase activity
C9423_RS06715	COG0450	alkyl hydroperoxide reductase
C9423_RS06730	COG0628	permease
C9423_RS06735	COG1846	Transcriptional regulator
C9423_RS06740	COG1764	response to oxidative stress
C9423_RS06745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C9423_RS06750	COG0366	Alpha amylase catalytic
C9423_RS06755	COG2182	Extracellular solute-binding protein
C9423_RS06760	COG1175	transmembrane transport
C9423_RS06765	COG3833	ABC-type maltose transport systems, permease component
C9423_RS06775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C9423_RS06785	COG0167	dihydroorotate dehydrogenase activity
C9423_RS06795	COG0534	Mate efflux family protein
C9423_RS06815	COG0194	GDP metabolic process
C9423_RS06820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C9423_RS06870	COG2244	polysaccharide biosynthetic process
C9423_RS06875	COG1307	EDD domain protein, DegV family
C9423_RS06915	COG2207	Transcriptional regulator
C9423_RS06920	COG1053	succinate dehydrogenase
C9423_RS06925	COG2271	Major facilitator Superfamily
C9423_RS06930	COG0366	Alpha amylase catalytic
C9423_RS06950	COG1309	transcriptional regulator
C9423_RS06955	COG4475	Protein of unknown function (DUF436)
C9423_RS06965	COG0351	phosphomethylpyrimidine kinase
C9423_RS06995	COG4974	Belongs to the 'phage' integrase family
C9423_RS07000	COG5002	protein histidine kinase activity
C9423_RS07005	COG0745	RESPONSE REGULATOR receiver
C9423_RS07065	COG0673	inositol 2-dehydrogenase activity
C9423_RS07090	COG0039	L-malate dehydrogenase activity
C9423_RS07150	COG0395	ABC-type sugar transport system, permease component
C9423_RS07155	COG4209	transmembrane transport
C9423_RS07220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C9423_RS07235	COG4120	Belongs to the binding-protein-dependent transport system permease family
C9423_RS07250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C9423_RS07265	COG2197	response regulator
C9423_RS07280	COG1464	Belongs to the NlpA lipoprotein family
C9423_RS07285	COG2011	ABC-type metal ion transport system permease component
C9423_RS07295	COG0546	phosphoglycolate phosphatase activity
C9423_RS07300	COG1349	DNA-binding transcription factor activity
C9423_RS07320	COG0477	Major facilitator Superfamily
C9423_RS07350	COG0284	orotidine-5'-phosphate decarboxylase activity
C9423_RS07360	COG0543	2 iron, 2 sulfur cluster binding
C9423_RS07365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C9423_RS07370	COG0505	Belongs to the CarA family
C9423_RS07375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C9423_RS07380	COG0540	Belongs to the ATCase OTCase family
C9423_RS07385	COG2233	PERMEase
C9423_RS07395	COG0564	pseudouridine synthase activity
C9423_RS07400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C9423_RS07415	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C9423_RS07425	COG1278	Cold shock
C9423_RS07435	COG0328	RNA-DNA hybrid ribonuclease activity
C9423_RS07450	COG4684	Psort location CytoplasmicMembrane, score
C9423_RS07455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C9423_RS07460	COG0513	Belongs to the DEAD box helicase family
C9423_RS07475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C9423_RS07480	COG1760	l-serine dehydratase
C9423_RS07485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C9423_RS07490	COG1760	l-serine dehydratase
C9423_RS07495	COG0531	amino acid
C9423_RS07500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9423_RS07525	COG1418	mRNA catabolic process
C9423_RS07530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C9423_RS07535	COG0116	Belongs to the methyltransferase superfamily
C9423_RS07545	COG3599	regulation of cell shape
C9423_RS07550	COG4474	Belongs to the UPF0398 family
C9423_RS07555	COG3331	DNA recombination
C9423_RS07560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9423_RS07570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C9423_RS07575	COG3935	DnaD domain protein
C9423_RS07585	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS07590	COG0735	belongs to the Fur family
C9423_RS07595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C9423_RS07600	COG1705	Flagellar rod assembly protein muramidase FlgJ
C9423_RS07600	COG1388	LysM domain
C9423_RS07615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9423_RS07635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9423_RS07640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C9423_RS07640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C9423_RS07645	COG5416	Lipopolysaccharide assembly protein A domain
C9423_RS07650	COG0300	oxidoreductase activity
C9423_RS07655	COG1234	tRNA 3'-trailer cleavage
C9423_RS07670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C9423_RS07700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C9423_RS07710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C9423_RS07715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C9423_RS07720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C9423_RS07725	COG0668	transmembrane transport
C9423_RS07730	COG0517	IMP dehydrogenase activity
C9423_RS07745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C9423_RS07750	COG1733	regulation of RNA biosynthetic process
C9423_RS07755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C9423_RS07765	COG0765	amino acid transport
C9423_RS07770	COG0765	amino acid transport
C9423_RS07775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9423_RS07780	COG1126	abc transporter atp-binding protein
C9423_RS07790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9423_RS07790	COG0072	phenylalanine-tRNA ligase activity
C9423_RS07795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C9423_RS07800	COG1733	regulation of RNA biosynthetic process
C9423_RS07805	COG1074	ATP-dependent DNA helicase activity
C9423_RS07810	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C9423_RS07815	COG3104	oligopeptide transport
C9423_RS07835	COG4990	cell redox homeostasis
C9423_RS07875	COG0589	response to stress
C9423_RS07880	COG3942	CHAP domain
C9423_RS07880	COG1388	LysM domain
C9423_RS07915	COG3620	sequence-specific DNA binding
C9423_RS07930	COG2151	metal-sulfur cluster biosynthetic enzyme
C9423_RS07935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C9423_RS07940	COG1666	GTP binding
C9423_RS07945	COG1199	ATP-dependent helicase activity
C9423_RS07945	COG1199	ATP-dependent helicase activity
C9423_RS07965	COG1968	undecaprenyl-diphosphatase activity
C9423_RS07970	COG2217	Heavy metal translocating P-type atpase
C9423_RS07975	COG2707	UPF0756 membrane protein
C9423_RS07985	COG0268	Binds directly to 16S ribosomal RNA
C9423_RS07990	COG1466	dna polymerase III delta subunit
C9423_RS07995	COG2333	competence protein COMEC
C9423_RS07995	COG0658	competence protein
C9423_RS08000	COG2131	deaminase
C9423_RS08010	COG3480	Lon protease (S16) C-terminal proteolytic domain
C9423_RS08015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C9423_RS08020	COG0742	ribosomal rna small subunit methyltransferase
C9423_RS08045	COG4471	UPF0298 protein
C9423_RS08060	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C9423_RS08065	COG0772	Belongs to the SEDS family
C9423_RS08070	COG4838	Belongs to the UPF0358 family
C9423_RS08075	COG0514	ATP-dependent DNA helicase (RecQ)
C9423_RS08080	COG1217	gtp-binding protein TYPA
C9423_RS08085	COG0483	inositol monophosphate 1-phosphatase activity
C9423_RS08090	COG4476	Belongs to the UPF0223 family
C9423_RS08120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9423_RS08135	COG4989	oxidoreductase activity
C9423_RS08150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C9423_RS08165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C9423_RS08170	COG0047	phosphoribosylformylglycinamidine synthase activity
C9423_RS08175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C9423_RS08180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C9423_RS08190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C9423_RS08195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C9423_RS08200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C9423_RS08205	COG2233	PERMEase
C9423_RS08210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9423_RS08225	COG1876	peptidase activity
C9423_RS08250	COG2268	Band 7 protein
C9423_RS08285	COG1131	(ABC) transporter
C9423_RS08295	COG1595	DNA-templated transcription, initiation
C9423_RS08305	COG2723	6-phospho-beta-galactosidase activity
C9423_RS08310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS08310	COG2190	(PTS) system
C9423_RS08310	COG1263	PTS System
C9423_RS08315	COG3711	transcriptional antiterminator
C9423_RS08345	COG0436	Aminotransferase
C9423_RS08360	COG1278	Cold shock
C9423_RS08375	COG3942	CHAP domain
C9423_RS08375	COG1388	LysM domain
C9423_RS08400	COG3711	transcriptional antiterminator
C9423_RS08420	COG1725	Transcriptional regulator
C9423_RS08455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9423_RS08460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9423_RS08495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C9423_RS08515	COG1073	alpha beta
C9423_RS08540	COG1227	inorganic diphosphatase activity
C9423_RS08545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C9423_RS08550	COG1882	Formate acetyltransferase
C9423_RS08565	COG1832	CoA-binding protein
C9423_RS08570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C9423_RS08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C9423_RS08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C9423_RS08590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C9423_RS08595	COG4974	Belongs to the 'phage' integrase family
C9423_RS08600	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C9423_RS08605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C9423_RS08610	COG0758	DNA mediated transformation
C9423_RS08615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C9423_RS08620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C9423_RS08625	COG1132	(ABC) transporter
C9423_RS08635	COG0095	Lipoate-protein ligase
C9423_RS08640	COG0681	Belongs to the peptidase S26 family
C9423_RS08645	COG4479	Belongs to the UPF0346 family
C9423_RS08655	COG4698	Protein conserved in bacteria
C9423_RS08660	COG2755	lipolytic protein G-D-S-L family
C9423_RS08665	COG1307	EDD domain protein, DegV family
C9423_RS08670	COG1272	protein, Hemolysin III
C9423_RS08680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C9423_RS08685	COG0488	(ABC) transporter
C9423_RS08690	COG0025	NhaP-type Na H and K H
C9423_RS08705	COG0617	tRNA 3'-terminal CCA addition
C9423_RS08710	COG1694	Mazg nucleotide pyrophosphohydrolase
C9423_RS08715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C9423_RS08720	COG5582	Belongs to the UPF0302 family
C9423_RS08725	COG0457	Tetratricopeptide repeat
C9423_RS08735	COG0776	regulation of translation
C9423_RS08740	COG1160	GTP binding
C9423_RS08745	COG0539	negative regulation of cytoplasmic translation
C9423_RS08750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C9423_RS08755	COG1705	Flagellar rod assembly protein muramidase FlgJ
C9423_RS08755	COG1388	LysM domain
C9423_RS08760	COG0514	ATP-dependent DNA helicase (RecQ)
C9423_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C9423_RS08785	COG1288	antiporter activity
C9423_RS08805	COG4115	mRNA cleavage
C9423_RS08815	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C9423_RS08820	COG1187	pseudouridine synthase activity
C9423_RS08825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C9423_RS08830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C9423_RS08840	COG4974	Belongs to the 'phage' integrase family
C9423_RS08845	COG0735	belongs to the Fur family
C9423_RS08850	COG2996	Protein conserved in bacteria
C9423_RS08860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C9423_RS08865	COG0358	DNA primase activity
C9423_RS08870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS08880	COG0741	lytic transglycosylase activity
C9423_RS08890	COG0392	lysyltransferase activity
C9423_RS08890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C9423_RS08900	COG1131	(ABC) transporter
C9423_RS08915	COG0346	lactoylglutathione lyase activity
C9423_RS08945	COG0656	L-ascorbic acid biosynthetic process
C9423_RS08960	COG0183	Belongs to the thiolase family
C9423_RS08965	COG3425	synthase
C9423_RS08995	COG1653	transport
C9423_RS09000	COG0395	ABC-type sugar transport system, permease component
C9423_RS09005	COG1175	transmembrane transport
C9423_RS09010	COG1609	Transcriptional regulator
C9423_RS09015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS09025	COG0351	phosphomethylpyrimidine kinase
C9423_RS09035	COG2723	6-phospho-beta-galactosidase activity
C9423_RS09040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS09045	COG2188	Transcriptional regulator
C9423_RS09050	COG0346	lactoylglutathione lyase activity
C9423_RS09060	COG1309	transcriptional regulator
C9423_RS09185	COG5002	protein histidine kinase activity
C9423_RS09190	COG0745	RESPONSE REGULATOR receiver
C9423_RS09195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C9423_RS09200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C9423_RS09210	COG0583	DNA-binding transcription factor activity
C9423_RS09225	COG0205	6-phosphofructokinase activity
C9423_RS09230	COG0587	DNA-directed DNA polymerase activity
C9423_RS09250	COG2252	PERMEase
C9423_RS09255	COG0561	phosphatase activity
C9423_RS09280	COG0768	penicillin binding
C9423_RS09285	COG1737	Transcriptional regulator
C9423_RS09290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C9423_RS09300	COG1942	4-Oxalocrotonate Tautomerase
C9423_RS09305	COG2217	Heavy metal translocating P-type atpase
C9423_RS09310	COG3973	AAA domain
C9423_RS09325	COG1323	Belongs to the UPF0348 family
C9423_RS09330	COG2226	methyltransferase
C9423_RS09335	COG0799	negative regulation of ribosome biogenesis
C9423_RS09340	COG1713	HD superfamily hydrolase involved in NAD metabolism
C9423_RS09345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C9423_RS09350	COG1534	Rna-binding protein
C9423_RS09355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C9423_RS09360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C9423_RS09365	COG1126	abc transporter atp-binding protein
C9423_RS09370	COG0765	amino acid transport
C9423_RS09385	COG0825	malonyl-CoA metabolic process
C9423_RS09390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C9423_RS09395	COG0439	Biotin carboxylase
C9423_RS09400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C9423_RS09405	COG0511	ligase activity, forming carbon-carbon bonds
C9423_RS09420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C9423_RS09430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C9423_RS09435	COG1846	Transcriptional regulator
C9423_RS09445	COG4703	Protein of unknown function (DUF1797)
C9423_RS09450	COG2084	Dehydrogenase
C9423_RS09455	COG0438	transferase activity, transferring glycosyl groups
C9423_RS09465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C9423_RS09470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS09475	COG0542	response to heat
C9423_RS09495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C9423_RS09500	COG1253	flavin adenine dinucleotide binding
C9423_RS09505	COG0628	permease
C9423_RS09515	COG3557	Belongs to the UPF0374 family
C9423_RS09520	COG1194	a g-specific adenine glycosylase
C9423_RS09525	COG2137	regulation of response to DNA damage stimulus
C9423_RS09530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C9423_RS09550	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C9423_RS09555	COG1316	TRANSCRIPTIONal
C9423_RS09600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C9423_RS09605	COG2246	polysaccharide biosynthetic process
C9423_RS09630	COG4841	protein insertion into membrane
C9423_RS09635	COG0569	domain protein
C9423_RS09640	COG2197	response regulator
C9423_RS09645	COG4585	Histidine kinase
C9423_RS09655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9423_RS09660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C9423_RS09680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9423_RS09690	COG0438	transferase activity, transferring glycosyl groups
C9423_RS09705	COG1216	Glycosyl transferase, family 2
C9423_RS09705	COG1442	glycosyl transferase family 8
C9423_RS09710	COG1216	Glycosyl transferase, family 2
C9423_RS09710	COG1442	glycosyl transferase family 8
C9423_RS09725	COG3475	LICD family
C9423_RS09730	COG0463	Glycosyl transferase, family 2
C9423_RS09735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C9423_RS09745	COG1216	Glycosyl transferase, family 2
C9423_RS09745	COG0438	transferase activity, transferring glycosyl groups
C9423_RS09750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9423_RS09760	COG1682	transport, permease protein
C9423_RS09775	COG1091	dTDP-4-dehydrorhamnose reductase activity
C9423_RS09780	COG1088	dTDP-glucose 4,6-dehydratase activity
C9423_RS09790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C9423_RS09810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C9423_RS09815	COG1295	ribonuclease BN
C9423_RS09820	COG0024	Methionine aminopeptidase
C9423_RS09825	COG0716	FMN binding
C9423_RS09835	COG2309	aminopeptidase activity
C9423_RS09870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS09880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C9423_RS09885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C9423_RS09885	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C9423_RS09895	COG0673	inositol 2-dehydrogenase activity
C9423_RS09910	COG1321	iron dependent repressor
C9423_RS09910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9423_RS09915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C9423_RS09920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C9423_RS09925	COG3599	regulation of cell shape
C9423_RS09930	COG2302	S4 RNA-binding domain
C9423_RS09935	COG0762	integral membrane protein
C9423_RS09940	COG1799	cell septum assembly
C9423_RS09945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C9423_RS09980	COG0768	penicillin binding
C9423_RS09985	COG4839	cell division protein FtsL
C9423_RS10015	COG0497	DNA recombination
C9423_RS10020	COG1438	arginine binding
C9423_RS10025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C9423_RS10030	COG0142	geranyltranstransferase activity
C9423_RS10035	COG1722	exodeoxyribonuclease VII activity
C9423_RS10040	COG1570	exodeoxyribonuclease VII activity
C9423_RS10045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C9423_RS10050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9423_RS10055	COG1302	Protein conserved in bacteria
C9423_RS10060	COG0006	proline dipeptidase activity
C9423_RS10075	COG3716	PTS system mannose fructose sorbose family IID component
C9423_RS10080	COG3715	PTS system
C9423_RS10090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS10090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS10095	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C9423_RS10095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C9423_RS10105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C9423_RS10115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C9423_RS10125	COG0659	secondary active sulfate transmembrane transporter activity
C9423_RS10130	COG3759	membrane
C9423_RS10140	COG4122	O-methyltransferase activity
C9423_RS10155	COG0095	Lipoate-protein ligase
C9423_RS10160	COG1234	tRNA 3'-trailer cleavage
C9423_RS10170	COG1363	Peptidase, m42
C9423_RS10175	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C9423_RS10180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C9423_RS10185	COG1696	Membrane protein involved in D-alanine export
C9423_RS10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C9423_RS10205	COG0577	efflux transmembrane transporter activity
C9423_RS10210	COG1136	(ABC) transporter
C9423_RS10215	COG1328	CTP reductase activity
C9423_RS10225	COG0602	queuosine metabolic process
C9423_RS10235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C9423_RS10240	COG0488	(ABC) transporter
C9423_RS10245	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS10250	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS10260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C9423_RS10290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C9423_RS10295	COG1177	transmembrane transport
C9423_RS10300	COG1176	ABC-type spermidine putrescine transport system, permease component I
C9423_RS10305	COG3842	ATPase activity
C9423_RS10315	COG0604	alcohol dehydrogenase
C9423_RS10325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C9423_RS10330	COG4684	Psort location CytoplasmicMembrane, score
C9423_RS10335	COG0702	epimerase
C9423_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
C9423_RS10340	COG0604	alcohol dehydrogenase
C9423_RS10340	COG3321	synthase
C9423_RS10365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C9423_RS10375	COG0708	Exodeoxyribonuclease III
C9423_RS10385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C9423_RS10390	COG0802	atpase or kinase
C9423_RS10395	COG0280	phosphate acetyltransferase
C9423_RS10400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C9423_RS10405	COG0561	phosphatase activity
C9423_RS10415	COG1609	Transcriptional regulator
C9423_RS10435	COG0346	lactoylglutathione lyase activity
C9423_RS10480	COG1780	Probably involved in ribonucleotide reductase function
C9423_RS10490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C9423_RS10500	COG0406	alpha-ribazole phosphatase activity
C9423_RS10510	COG1929	Belongs to the glycerate kinase type-1 family
C9423_RS10515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C9423_RS10540	COG1113	amino acid transport
C9423_RS10545	COG1757	Na H antiporter
C9423_RS10550	COG1473	amidohydrolase
C9423_RS10555	COG1464	Belongs to the NlpA lipoprotein family
C9423_RS10560	COG2011	ABC-type metal ion transport system permease component
C9423_RS10565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C9423_RS10575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9423_RS10580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9423_RS10585	COG0105	UTP biosynthetic process
C9423_RS10595	COG1368	sulfuric ester hydrolase activity
C9423_RS10610	COG2723	6-phospho-beta-galactosidase activity
C9423_RS10625	COG1428	Deoxynucleoside kinase
C9423_RS10650	COG1846	Transcriptional regulator
C9423_RS10670	COG3964	amidohydrolase
C9423_RS10700	COG3711	transcriptional antiterminator
C9423_RS10705	COG3764	Sortase (surface protein transpeptidase)
C9423_RS10715	COG1733	regulation of RNA biosynthetic process
C9423_RS10720	COG2814	Major facilitator Superfamily
C9423_RS10730	COG2814	Major facilitator Superfamily
C9423_RS10740	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C9423_RS10745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS10745	COG1263	PTS System
C9423_RS10745	COG2190	(PTS) system
C9423_RS10750	COG1263	PTS System
C9423_RS10750	COG2190	(PTS) system
C9423_RS10750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS10760	COG1597	lipid kinase activity
C9423_RS10795	COG0604	alcohol dehydrogenase
C9423_RS10850	COG1744	ABC transporter substrate-binding protein PnrA-like
C9423_RS10860	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C9423_RS10875	COG3639	organic phosphonate transmembrane transporter activity
C9423_RS10880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C9423_RS10885	COG0737	Belongs to the 5'-nucleotidase family
C9423_RS10900	COG3850	Histidine kinase
C9423_RS10900	COG5002	protein histidine kinase activity
C9423_RS10910	COG5002	protein histidine kinase activity
C9423_RS10910	COG3850	Histidine kinase
C9423_RS11025	COG0719	Fe-S assembly protein
C9423_RS11035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C9423_RS11040	COG0719	Fe-S assembly protein
C9423_RS11050	COG1464	Belongs to the NlpA lipoprotein family
C9423_RS11055	COG2011	ABC-type metal ion transport system permease component
C9423_RS11060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C9423_RS11065	COG0509	glycine decarboxylation via glycine cleavage system
C9423_RS11070	COG1393	Belongs to the ArsC family
C9423_RS11075	COG0772	Belongs to the SEDS family
C9423_RS11080	COG0583	DNA-binding transcription factor activity
C9423_RS11090	COG2855	membrane
C9423_RS11095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C9423_RS11105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C9423_RS11110	COG1263	PTS System
C9423_RS11110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS11130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C9423_RS11140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C9423_RS11145	COG0009	L-threonylcarbamoyladenylate synthase
C9423_RS11150	COG2890	protein-(glutamine-N5) methyltransferase activity
C9423_RS11155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C9423_RS11160	COG1435	thymidine kinase activity
C9423_RS11165	COG0681	Belongs to the peptidase S26 family
C9423_RS11185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C9423_RS11195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C9423_RS11200	COG3442	glutamine amidotransferase
C9423_RS11265	COG4975	Glucose uptake
C9423_RS11270	COG1869	D-ribose catabolic process
C9423_RS11280	COG1482	cell wall glycoprotein biosynthetic process
C9423_RS11310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C9423_RS11315	COG0628	permease
C9423_RS11320	COG3731	PTS system glucitol sorbitol-specific IIA component
C9423_RS11325	COG2706	6-phosphogluconolactonase activity
C9423_RS11330	COG1104	cysteine desulfurase activity
C9423_RS11335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9423_RS11345	COG3590	peptidase
C9423_RS11355	COG1335	isochorismatase
C9423_RS11360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C9423_RS11370	COG0494	nUDIX hydrolase
C9423_RS11380	COG3853	Toxic anion resistance protein (TelA)
C9423_RS11385	COG0531	amino acid
C9423_RS11390	COG4975	Glucose uptake
C9423_RS11395	COG0642	Histidine kinase
C9423_RS11400	COG0745	RESPONSE REGULATOR receiver
C9423_RS11425	COG3546	catalase activity
C9423_RS11430	COG1764	response to oxidative stress
C9423_RS11440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9423_RS11445	COG1438	arginine binding
C9423_RS11455	COG0477	Major facilitator Superfamily
C9423_RS11475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C9423_RS11490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9423_RS11495	COG1121	(ABC) transporter
C9423_RS11500	COG1113	amino acid transport
C9423_RS11510	COG2249	NAD(P)H dehydrogenase (quinone) activity
C9423_RS11515	COG2207	Transcriptional regulator
C9423_RS11525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C9423_RS11555	COG4862	establishment of competence for transformation
C9423_RS11565	COG1393	Belongs to the ArsC family
C9423_RS11575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C9423_RS11580	COG0419	ATPase involved in DNA repair
C9423_RS11585	COG0420	3'-5' exonuclease activity
C9423_RS11590	COG0204	Acyl-transferase
C9423_RS11595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C9423_RS11600	COG2827	Endonuclease containing a URI domain
C9423_RS11615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C9423_RS11620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C9423_RS11625	COG0124	histidyl-tRNA synthetase
C9423_RS11635	COG0667	Aldo Keto reductase
C9423_RS11640	COG1490	D-aminoacyl-tRNA deacylase activity
C9423_RS11645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9423_RS11650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9423_RS11655	COG2264	protein methyltransferase activity
C9423_RS11665	COG2094	Belongs to the DNA glycosylase MPG family
C9423_RS11680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C9423_RS11695	COG0589	response to stress
C9423_RS11700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C9423_RS11730	COG4537	Required for transformation and DNA binding
C9423_RS11735	COG1459	type II secretion system
C9423_RS11740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C9423_RS11750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C9423_RS11765	COG4473	ABC transporter
C9423_RS11770	COG1131	(ABC) transporter
C9423_RS11775	COG0537	adenosine 5'-monophosphoramidase activity
C9423_RS11785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9423_RS11795	COG3481	metal-dependent phosphohydrolase, HD sub domain
C9423_RS11800	COG4717	serine-type aminopeptidase activity
C9423_RS11825	COG3507	Belongs to the glycosyl hydrolase 43 family
C9423_RS11840	COG1609	Transcriptional regulator
C9423_RS11850	COG2721	sulfolactate sulfo-lyase activity
C9423_RS11855	COG1904	glucuronate isomerase
C9423_RS11860	COG2755	lipolytic protein G-D-S-L family
C9423_RS11870	COG1132	(ABC) transporter
C9423_RS11885	COG3679	Belongs to the UPF0342 family
C9423_RS11890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9423_RS11895	COG0564	pseudouridine synthase activity
C9423_RS11900	COG1940	carbohydrate kinase activity
C9423_RS11905	COG0383	alpha-mannosidase activity
C9423_RS11930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C9423_RS11960	COG1363	Peptidase, m42
C9423_RS11975	COG1764	response to oxidative stress
C9423_RS11980	COG2261	transglycosylase associated protein
C9423_RS12040	COG1051	belongs to the nudix hydrolase family
C9423_RS12055	COG1473	amidohydrolase
C9423_RS12085	COG1914	H( )-stimulated, divalent metal cation uptake system
C9423_RS12090	COG1121	(ABC) transporter
C9423_RS12095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9423_RS12100	COG0803	Belongs to the bacterial solute-binding protein 9 family
C9423_RS12105	COG1321	iron dependent repressor
C9423_RS12120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C9423_RS12135	COG0390	transport system, permease component
C9423_RS12140	COG4619	ABC transporter
C9423_RS12145	COG0662	Cupin 2, conserved barrel domain protein
C9423_RS12200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9423_RS12205	COG2176	DNA-directed DNA polymerase activity
C9423_RS12210	COG1192	Involved in chromosome partitioning
C9423_RS12235	COG3328	transposase activity
C9423_RS12250	COG2274	protein secretion by the type I secretion system
C9423_RS12255	COG3328	transposase activity
C9423_RS12290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C9423_RS12300	COG1733	regulation of RNA biosynthetic process
C9423_RS12305	COG2801	Transposase and inactivated derivatives
C9423_RS12335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS12335	COG3711	transcriptional antiterminator
C9423_RS12340	COG0800	Aldolase
C9423_RS12345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C9423_RS12405	COG0582	viral genome integration into host DNA
C9423_RS12420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9423_RS12440	COG2217	Heavy metal translocating P-type atpase
C9423_RS12455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9423_RS12460	COG0783	Belongs to the Dps family
C9423_RS12470	COG3328	transposase activity
C9423_RS12500	COG0484	heat shock protein binding
C9423_RS12600	COG0588	phosphoglycerate mutase activity
C9423_RS12605	COG0534	Mate efflux family protein
C9423_RS12625	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C9423_RS12630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C9423_RS12635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9423_RS12640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9423_RS12650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C9423_RS12655	COG1363	Peptidase, m42
C9423_RS12675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C9423_RS12685	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS12690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C9423_RS12695	COG1937	Protein conserved in bacteria
C9423_RS12705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C9423_RS12710	COG1193	negative regulation of DNA recombination
C9423_RS12725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C9423_RS12730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C9423_RS12735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C9423_RS12745	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9423_RS12760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C9423_RS12765	COG0163	prenyltransferase activity
C9423_RS12785	COG2814	Major facilitator Superfamily
C9423_RS12795	COG1695	Transcriptional regulator
C9423_RS12800	COG3479	Phenolic acid decarboxylase
C9423_RS12820	COG2190	(PTS) system
C9423_RS12820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS12820	COG1263	PTS System
C9423_RS12830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9423_RS12840	COG1609	Transcriptional regulator
C9423_RS12850	COG1757	Na H antiporter
C9423_RS12855	COG0531	amino acid
C9423_RS12880	COG1461	Dihydroxyacetone kinase
C9423_RS12885	COG2376	Dihydroxyacetone kinase
C9423_RS12890	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C9423_RS12900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS12900	COG2190	(PTS) system
C9423_RS12900	COG1263	PTS System
C9423_RS12915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C9423_RS12975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C9423_RS12980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C9423_RS12985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C9423_RS12990	COG3397	chitin binding
C9423_RS13005	COG1428	Deoxynucleoside kinase
C9423_RS13010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C9423_RS13025	COG1304	FMN binding
C9423_RS13030	COG1028	Short-chain dehydrogenase reductase Sdr
C9423_RS13035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C9423_RS13045	COG0800	Aldolase
C9423_RS13050	COG1414	Transcriptional regulator
C9423_RS13065	COG1012	belongs to the aldehyde dehydrogenase family
C9423_RS13065	COG1454	alcohol dehydrogenase
C9423_RS13070	COG1862	Preprotein translocase
C9423_RS13075	COG0343	queuine tRNA-ribosyltransferase activity
C9423_RS13095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C9423_RS13115	COG1174	glycine betaine transport
C9423_RS13125	COG0531	amino acid
C9423_RS13140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C9423_RS13145	COG2337	Toxic component of a toxin-antitoxin (TA) module
C9423_RS13150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C9423_RS13155	COG0736	holo-[acyl-carrier-protein] synthase activity
C9423_RS13165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C9423_RS13170	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9423_RS13185	COG1671	Belongs to the UPF0178 family
C9423_RS13200	COG0456	acetyltransferase
C9423_RS13210	COG0572	uridine kinase
C9423_RS13215	COG1011	Hydrolase
C9423_RS13220	COG1187	pseudouridine synthase activity
C9423_RS13225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C9423_RS13235	COG0534	Mate efflux family protein
C9423_RS13240	COG1253	flavin adenine dinucleotide binding
C9423_RS13255	COG3158	transport of potassium into the cell
C9423_RS13265	COG1132	(ABC) transporter
C9423_RS13270	COG1396	sequence-specific DNA binding
C9423_RS13280	COG1185	polyribonucleotide nucleotidyltransferase activity
C9423_RS13285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C9423_RS13290	COG0242	peptide deformylase activity
C9423_RS13300	COG1827	regulation of RNA biosynthetic process
C9423_RS13305	COG0110	maltose O-acetyltransferase activity
C9423_RS13310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C9423_RS13325	COG0765	amino acid transport
C9423_RS13330	COG1126	abc transporter atp-binding protein
C9423_RS13375	COG1113	amino acid transport
C9423_RS13385	COG1114	Component of the transport system for branched-chain amino acids
C9423_RS13400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9423_RS13410	COG2255	four-way junction helicase activity
C9423_RS13415	COG0632	four-way junction helicase activity
C9423_RS13425	COG2188	Transcriptional regulator
C9423_RS13430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C9423_RS13430	COG1263	PTS System
C9423_RS13435	COG0424	maF-like protein
C9423_RS13440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C9423_RS13445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C9423_RS13455	COG1692	metallophosphoesterase
C9423_RS13460	COG0697	spore germination
C9423_RS13470	COG0561	phosphatase activity
C9423_RS13485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C9423_RS13490	COG1268	BioY protein
C9423_RS13515	COG1346	cytolysis
C9423_RS13520	COG1380	Effector of murein hydrolase LrgA
C9423_RS13525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C9423_RS13560	COG4607	ABC-type enterochelin transport system periplasmic component
C9423_RS13565	COG4604	ABC transporter, ATP-binding protein
C9423_RS13570	COG4605	iron ion homeostasis
C9423_RS13575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C9423_RS13585	COG2918	glutathione biosynthetic process
C9423_RS13585	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9423_RS13590	COG0552	protein localization to endoplasmic reticulum
C9423_RS13595	COG0561	phosphatase activity
C9423_RS13600	COG1196	nuclear chromosome segregation
C9423_RS13605	COG0571	ribonuclease III activity
C9423_RS13620	COG0601	transmembrane transport
C9423_RS13625	COG4608	Belongs to the ABC transporter superfamily
C9423_RS13635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C9423_RS13640	COG0416	fatty acid biosynthetic process
C9423_RS13645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C9423_RS13650	COG1461	Dihydroxyacetone kinase
C9423_RS13665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C9423_RS13685	COG1122	ATPase activity
C9423_RS13690	COG1122	ATPase activity
C9423_RS13695	COG0203	ribosomal protein L17
C9423_RS13700	COG0202	RNA polymerase activity
C9423_RS13705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C9423_RS13710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C9423_RS13715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C9423_RS13720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C9423_RS13725	COG0563	adenylate kinase activity
C9423_RS13730	COG0201	protein transport
C9423_RS13735	COG0200	Binds to the 23S rRNA
C9423_RS13740	COG1841	ribosomal large subunit assembly
C9423_RS13745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C9423_RS13750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C9423_RS13755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C9423_RS13760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C9423_RS13765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C9423_RS13770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C9423_RS13775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C9423_RS13780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C9423_RS13785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C9423_RS13790	COG0255	Belongs to the universal ribosomal protein uL29 family
C9423_RS13800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C9423_RS13805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C9423_RS13815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C9423_RS13820	COG0089	rRNA binding
C9423_RS13825	COG0088	Forms part of the polypeptide exit tunnel
C9423_RS13830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C9423_RS13835	COG0051	transcription antitermination factor activity, RNA binding
C9423_RS13850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS13850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS13855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS13860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS13860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9423_RS13860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9423_RS13870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C9423_RS13875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C9423_RS13880	COG0049	tRNA binding
C9423_RS13885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C9423_RS13890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C9423_RS13900	COG0588	phosphoglycerate mutase activity
C9423_RS13905	COG0813	purine-nucleoside phosphorylase activity
C9423_RS13915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C9423_RS13920	COG1079	Belongs to the binding-protein-dependent transport system permease family
C9423_RS13925	COG4603	Belongs to the binding-protein-dependent transport system permease family
C9423_RS13930	COG3845	ABC transporter
C9423_RS13935	COG1744	ABC transporter substrate-binding protein PnrA-like
C9423_RS13940	COG0295	cytidine deaminase activity
C9423_RS13945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C9423_RS13950	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C9423_RS13955	COG1609	Transcriptional regulator
C9423_RS13960	COG2813	Specifically methylates the guanine in position
C9423_RS13965	COG1072	(Pantothenic acid kinase))
C9423_RS13970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9423_RS13970	COG0519	Catalyzes the synthesis of GMP from XMP
C9423_RS14010	COG0028	Belongs to the TPP enzyme family
C9423_RS14020	COG0488	(ABC) transporter
C9423_RS14030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C9423_RS14040	COG0305	Participates in initiation and elongation during chromosome replication
C9423_RS14045	COG0359	binds to the 23S rRNA
C9423_RS14055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C9423_RS14060	COG0629	single-stranded DNA binding
C9423_RS14065	COG0360	Binds together with S18 to 16S ribosomal RNA
C9423_RS14080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C9423_RS14085	COG2501	S4 domain
C9423_RS14090	COG0592	DNA-directed DNA polymerase activity