locus-tag	class	description
LACWKB8_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LACWKB8_RS00010	COG0592	DNA-directed DNA polymerase activity
LACWKB8_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LACWKB8_RS00025	COG0187	DNA topoisomerase II activity
LACWKB8_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LACWKB8_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LACWKB8_RS00040	COG0629	single-stranded DNA binding
LACWKB8_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LACWKB8_RS00055	COG0359	binds to the 23S rRNA
LACWKB8_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LACWKB8_RS00070	COG1285	pathogenesis
LACWKB8_RS00090	COG1132	(ABC) transporter
LACWKB8_RS00105	COG3590	peptidase
LACWKB8_RS00115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACWKB8_RS00130	COG3250	beta-galactosidase activity
LACWKB8_RS00135	COG2211	Major facilitator Superfamily
LACWKB8_RS00145	COG1940	carbohydrate kinase activity
LACWKB8_RS00170	COG3534	alpha-L-arabinofuranosidase
LACWKB8_RS00175	COG2017	converts alpha-aldose to the beta-anomer
LACWKB8_RS00195	COG1131	(ABC) transporter
LACWKB8_RS00205	COG1132	(ABC) transporter
LACWKB8_RS00225	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LACWKB8_RS00230	COG0366	Alpha amylase catalytic
LACWKB8_RS00235	COG2188	Transcriptional regulator
LACWKB8_RS00240	COG2190	(PTS) system
LACWKB8_RS00240	COG1263	PTS System
LACWKB8_RS00240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS00275	COG1454	alcohol dehydrogenase
LACWKB8_RS00280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LACWKB8_RS00285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LACWKB8_RS00290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LACWKB8_RS00295	COG2188	Transcriptional regulator
LACWKB8_RS00300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS00300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS00305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS00320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LACWKB8_RS00325	COG1063	alcohol dehydrogenase
LACWKB8_RS00330	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS00350	COG1609	Transcriptional regulator
LACWKB8_RS00355	COG2190	(PTS) system
LACWKB8_RS00360	COG4152	abc transporter atp-binding protein
LACWKB8_RS00365	COG1668	transmembrane transport
LACWKB8_RS00375	COG4555	ABC transporter
LACWKB8_RS00390	COG0583	DNA-binding transcription factor activity
LACWKB8_RS00395	COG0789	Transcriptional regulator
LACWKB8_RS00405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LACWKB8_RS00415	COG2084	Dehydrogenase
LACWKB8_RS00420	COG2096	Adenosyltransferase
LACWKB8_RS00435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LACWKB8_RS00440	COG1011	Hydrolase
LACWKB8_RS00445	COG0656	L-ascorbic acid biosynthetic process
LACWKB8_RS00450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LACWKB8_RS00455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACWKB8_RS00460	COG0708	Exodeoxyribonuclease III
LACWKB8_RS00465	COG0556	nucleotide-excision repair
LACWKB8_RS00475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACWKB8_RS00505	COG1053	succinate dehydrogenase
LACWKB8_RS00505	COG3976	FMN-binding domain protein
LACWKB8_RS00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LACWKB8_RS00515	COG1024	Enoyl-CoA hydratase
LACWKB8_RS00520	COG2070	2-Nitropropane dioxygenase
LACWKB8_RS00525	COG2030	dehydratase
LACWKB8_RS00530	COG4670	ketone body catabolic process
LACWKB8_RS00535	COG0583	DNA-binding transcription factor activity
LACWKB8_RS00555	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LACWKB8_RS00560	COG0583	DNA-binding transcription factor activity
LACWKB8_RS00565	COG2271	Major facilitator Superfamily
LACWKB8_RS00570	COG3976	FMN-binding domain protein
LACWKB8_RS00570	COG1053	succinate dehydrogenase
LACWKB8_RS00575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LACWKB8_RS00580	COG0710	3-dehydroquinate dehydratase activity
LACWKB8_RS00620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LACWKB8_RS00625	COG2188	Transcriptional regulator
LACWKB8_RS00680	COG0745	RESPONSE REGULATOR receiver
LACWKB8_RS00685	COG5002	protein histidine kinase activity
LACWKB8_RS00700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LACWKB8_RS00705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LACWKB8_RS00710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LACWKB8_RS00720	COG1129	ABC transporter
LACWKB8_RS00730	COG0501	Belongs to the peptidase M48B family
LACWKB8_RS00735	COG1704	LemA family
LACWKB8_RS00740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LACWKB8_RS00785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LACWKB8_RS00805	COG1126	abc transporter atp-binding protein
LACWKB8_RS00810	COG0765	amino acid transport
LACWKB8_RS00815	COG2094	Belongs to the DNA glycosylase MPG family
LACWKB8_RS00820	COG3189	MarR family transcriptional regulator
LACWKB8_RS00825	COG0861	Integral membrane protein TerC family
LACWKB8_RS00830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LACWKB8_RS00835	COG2502	aspartate--ammonia ligase
LACWKB8_RS00840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACWKB8_RS00845	COG0246	Mannitol dehydrogenase
LACWKB8_RS00850	COG2213	PTS system mannitol-specific
LACWKB8_RS00850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS00860	COG1349	DNA-binding transcription factor activity
LACWKB8_RS00880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LACWKB8_RS00890	COG0328	RNA-DNA hybrid ribonuclease activity
LACWKB8_RS00900	COG0463	Glycosyl transferase, family 2
LACWKB8_RS00900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LACWKB8_RS00910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LACWKB8_RS00940	COG1181	Belongs to the D-alanine--D-alanine ligase family
LACWKB8_RS00960	COG0657	acetylesterase activity
LACWKB8_RS00960	COG2755	lipolytic protein G-D-S-L family
LACWKB8_RS00990	COG3775	system Galactitol-specific IIC component
LACWKB8_RS01040	COG0308	aminopeptidase N
LACWKB8_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS01060	COG1263	PTS System
LACWKB8_RS01065	COG1486	melibiose metabolic process
LACWKB8_RS01075	COG3104	oligopeptide transport
LACWKB8_RS01085	COG1136	(ABC) transporter
LACWKB8_RS01100	COG1132	(ABC) transporter
LACWKB8_RS01130	COG1252	NADH dehydrogenase
LACWKB8_RS01185	COG0406	alpha-ribazole phosphatase activity
LACWKB8_RS01195	COG3973	AAA domain
LACWKB8_RS01210	COG1072	(Pantothenic acid kinase))
LACWKB8_RS01215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LACWKB8_RS01230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS01230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS01235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS01240	COG3715	PTS system
LACWKB8_RS01245	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS01275	COG2197	response regulator
LACWKB8_RS01280	COG4585	Histidine kinase
LACWKB8_RS01295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS01320	COG3022	response to hydroperoxide
LACWKB8_RS01325	COG0588	phosphoglycerate mutase activity
LACWKB8_RS01340	COG1136	(ABC) transporter
LACWKB8_RS01355	COG0431	NADPH-dependent FMN reductase
LACWKB8_RS01360	COG0431	NADPH-dependent FMN reductase
LACWKB8_RS01380	COG0357	Ribosomal RNA small subunit methyltransferase G
LACWKB8_RS01385	COG1475	DNA binding
LACWKB8_RS01390	COG1192	Involved in chromosome partitioning
LACWKB8_RS01395	COG1475	DNA binding
LACWKB8_RS01400	COG4481	Protein conserved in bacteria
LACWKB8_RS01405	COG0012	GTP binding
LACWKB8_RS01415	COG1132	(ABC) transporter
LACWKB8_RS01420	COG1132	(ABC) transporter
LACWKB8_RS01425	COG1174	glycine betaine transport
LACWKB8_RS01435	COG0745	RESPONSE REGULATOR receiver
LACWKB8_RS01445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LACWKB8_RS01515	COG2801	Transposase and inactivated derivatives
LACWKB8_RS01525	COG3775	system Galactitol-specific IIC component
LACWKB8_RS01530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACWKB8_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS01540	COG1070	Carbohydrate kinase
LACWKB8_RS01545	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LACWKB8_RS01550	COG1830	Aldolase
LACWKB8_RS01555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LACWKB8_RS01555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LACWKB8_RS01560	COG0307	riboflavin synthase, alpha
LACWKB8_RS01570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LACWKB8_RS01590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS01600	COG3711	transcriptional antiterminator
LACWKB8_RS01620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS01625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS01630	COG3715	PTS system
LACWKB8_RS01635	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS01640	COG4948	Mandelate Racemase Muconate Lactonizing
LACWKB8_RS01655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LACWKB8_RS01660	COG4120	Belongs to the binding-protein-dependent transport system permease family
LACWKB8_RS01675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LACWKB8_RS01675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
LACWKB8_RS01690	COG3715	PTS system
LACWKB8_RS01695	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS01700	COG1285	pathogenesis
LACWKB8_RS01705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LACWKB8_RS01710	COG4989	oxidoreductase activity
LACWKB8_RS01715	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
LACWKB8_RS01720	COG1518	maintenance of DNA repeat elements
LACWKB8_RS01745	COG2267	carboxylic ester hydrolase activity
LACWKB8_RS01770	COG2176	DNA-directed DNA polymerase activity
LACWKB8_RS01790	COG0395	ABC-type sugar transport system, permease component
LACWKB8_RS01825	COG1033	growth of symbiont in host cell
LACWKB8_RS01825	COG2409	Drug exporters of the RND superfamily
LACWKB8_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
LACWKB8_RS01850	COG0398	Pfam SNARE associated Golgi protein
LACWKB8_RS01855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LACWKB8_RS01860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LACWKB8_RS01900	COG3715	PTS system
LACWKB8_RS01905	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS01920	COG1113	amino acid transport
LACWKB8_RS01925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LACWKB8_RS01930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LACWKB8_RS01945	COG4991	sh3 domain protein
LACWKB8_RS01945	COG0515	serine threonine protein kinase
LACWKB8_RS01945	COG3064	Membrane
LACWKB8_RS01950	COG1132	(ABC) transporter
LACWKB8_RS02020	COG0789	Transcriptional regulator
LACWKB8_RS02020	COG4978	Transcriptional regulator
LACWKB8_RS02025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACWKB8_RS02060	COG0698	ribose 5-phosphate isomerase
LACWKB8_RS02075	COG4565	transcriptional regulatory protein
LACWKB8_RS02080	COG3290	protein histidine kinase activity
LACWKB8_RS02085	COG3414	Phosphotransferase system galactitol-specific IIB component
LACWKB8_RS02095	COG1349	DNA-binding transcription factor activity
LACWKB8_RS02100	COG3775	system Galactitol-specific IIC component
LACWKB8_RS02110	COG3684	Belongs to the aldolase LacD family
LACWKB8_RS02135	COG0584	glycerophosphoryl diester phosphodiesterase
LACWKB8_RS02140	COG0436	Aminotransferase
LACWKB8_RS02165	COG2188	Transcriptional regulator
LACWKB8_RS02175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LACWKB8_RS02185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LACWKB8_RS02195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LACWKB8_RS02200	COG4472	Bacterial protein of unknown function (DUF965)
LACWKB8_RS02205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LACWKB8_RS02210	COG3906	Belongs to the UPF0473 family
LACWKB8_RS02215	COG1193	negative regulation of DNA recombination
LACWKB8_RS02220	COG3118	belongs to the thioredoxin family
LACWKB8_RS02225	COG1970	mechanosensitive ion channel activity
LACWKB8_RS02235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LACWKB8_RS02240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LACWKB8_RS02245	COG0668	transmembrane transport
LACWKB8_RS02260	COG0006	proline dipeptidase activity
LACWKB8_RS02280	COG0737	Belongs to the 5'-nucleotidase family
LACWKB8_RS02290	COG0647	UMP catabolic process
LACWKB8_RS02300	COG0586	Pfam SNARE associated Golgi protein
LACWKB8_RS02305	COG0492	ferredoxin-NADP+ reductase activity
LACWKB8_RS02460	COG0438	transferase activity, transferring glycosyl groups
LACWKB8_RS02465	COG0438	transferase activity, transferring glycosyl groups
LACWKB8_RS02475	COG1368	sulfuric ester hydrolase activity
LACWKB8_RS02485	COG0557	exoribonuclease II activity
LACWKB8_RS02490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LACWKB8_RS02500	COG1253	flavin adenine dinucleotide binding
LACWKB8_RS02505	COG0037	tRNA processing
LACWKB8_RS02505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LACWKB8_RS02520	COG0572	uridine kinase
LACWKB8_RS02535	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS02540	COG1053	succinate dehydrogenase
LACWKB8_RS02550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS02555	COG1447	Phosphotransferase system cellobiose-specific component IIA
LACWKB8_RS02560	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS02570	COG0783	Belongs to the Dps family
LACWKB8_RS02575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LACWKB8_RS02585	COG2188	Transcriptional regulator
LACWKB8_RS02595	COG1349	DNA-binding transcription factor activity
LACWKB8_RS02610	COG1956	GAF domain-containing protein
LACWKB8_RS02620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACWKB8_RS02630	COG0765	amino acid transport
LACWKB8_RS02645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACWKB8_RS02655	COG0656	L-ascorbic acid biosynthetic process
LACWKB8_RS02665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LACWKB8_RS02685	COG1846	Transcriptional regulator
LACWKB8_RS02690	COG1132	(ABC) transporter
LACWKB8_RS02700	COG1705	Flagellar rod assembly protein muramidase FlgJ
LACWKB8_RS02710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LACWKB8_RS02715	COG4851	CamS sex pheromone cAM373 precursor
LACWKB8_RS02720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LACWKB8_RS02730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LACWKB8_RS02735	COG1597	lipid kinase activity
LACWKB8_RS02755	COG3730	PTS system glucitol sorbitol-specific
LACWKB8_RS02760	COG3732	PTS system glucitol sorbitol-specific
LACWKB8_RS02770	COG0670	Belongs to the BI1 family
LACWKB8_RS02775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LACWKB8_RS02825	COG3279	Response regulator of the LytR AlgR family
LACWKB8_RS02845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LACWKB8_RS02855	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
LACWKB8_RS02860	COG1228	amidohydrolase
LACWKB8_RS02865	COG3576	pyridoxamine 5-phosphate
LACWKB8_RS02870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACWKB8_RS02880	COG0513	Belongs to the DEAD box helicase family
LACWKB8_RS02885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS02900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS02900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS02905	COG3715	PTS system
LACWKB8_RS02935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LACWKB8_RS02950	COG0716	FMN binding
LACWKB8_RS02955	COG0024	Methionine aminopeptidase
LACWKB8_RS02965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LACWKB8_RS02970	COG0183	Belongs to the thiolase family
LACWKB8_RS02980	COG3425	synthase
LACWKB8_RS02995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LACWKB8_RS03015	COG1253	flavin adenine dinucleotide binding
LACWKB8_RS03020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LACWKB8_RS03030	COG0542	response to heat
LACWKB8_RS03050	COG1393	Belongs to the ArsC family
LACWKB8_RS03075	COG2357	RelA SpoT domain protein
LACWKB8_RS03080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LACWKB8_RS03085	COG0564	pseudouridine synthase activity
LACWKB8_RS03090	COG2706	6-phosphogluconolactonase activity
LACWKB8_RS03095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACWKB8_RS03105	COG0628	permease
LACWKB8_RS03120	COG1674	ftsk spoiiie
LACWKB8_RS03120	COG1280	lysine exporter protein (LysE YggA)
LACWKB8_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS03130	COG1426	Protein conserved in bacteria
LACWKB8_RS03135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LACWKB8_RS03155	COG1174	glycine betaine transport
LACWKB8_RS03160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LACWKB8_RS03165	COG1418	mRNA catabolic process
LACWKB8_RS03170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LACWKB8_RS03175	COG1739	Uncharacterized protein family UPF0029
LACWKB8_RS03180	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LACWKB8_RS03195	COG0653	protein targeting
LACWKB8_RS03200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LACWKB8_RS03210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LACWKB8_RS03215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LACWKB8_RS03220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LACWKB8_RS03225	COG0492	ferredoxin-NADP+ reductase activity
LACWKB8_RS03230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACWKB8_RS03235	COG0556	nucleotide-excision repair
LACWKB8_RS03240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACWKB8_RS03250	COG1660	Displays ATPase and GTPase activities
LACWKB8_RS03255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LACWKB8_RS03260	COG1481	regulation of sporulation
LACWKB8_RS03265	COG0740	serine-type endopeptidase activity
LACWKB8_RS03285	COG0531	amino acid
LACWKB8_RS03295	COG1131	(ABC) transporter
LACWKB8_RS03310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LACWKB8_RS03315	COG1414	Transcriptional regulator
LACWKB8_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS03325	COG3775	system Galactitol-specific IIC component
LACWKB8_RS03330	COG2390	Transcriptional regulator
LACWKB8_RS03340	COG0126	phosphoglycerate kinase activity
LACWKB8_RS03345	COG0149	triose-phosphate isomerase activity
LACWKB8_RS03380	COG0561	phosphatase activity
LACWKB8_RS03385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LACWKB8_RS03390	COG0280	phosphate acetyltransferase
LACWKB8_RS03395	COG0802	atpase or kinase
LACWKB8_RS03405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LACWKB8_RS03410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LACWKB8_RS03420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACWKB8_RS03425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LACWKB8_RS03450	COG0477	Major facilitator Superfamily
LACWKB8_RS03460	COG0517	IMP dehydrogenase activity
LACWKB8_RS03460	COG0516	GMP reductase activity
LACWKB8_RS03465	COG0842	Transport permease protein
LACWKB8_RS03465	COG1129	ABC transporter
LACWKB8_RS03490	COG2217	Heavy metal translocating P-type atpase
LACWKB8_RS03505	COG4555	ABC transporter
LACWKB8_RS03520	COG0561	phosphatase activity
LACWKB8_RS03525	COG0531	amino acid
LACWKB8_RS03530	COG0217	transcriptional regulatory protein
LACWKB8_RS03560	COG2249	NAD(P)H dehydrogenase (quinone) activity
LACWKB8_RS03565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LACWKB8_RS03595	COG0827	DNA restriction-modification system
LACWKB8_RS03600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LACWKB8_RS03615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LACWKB8_RS03625	COG1482	cell wall glycoprotein biosynthetic process
LACWKB8_RS03635	COG0745	RESPONSE REGULATOR receiver
LACWKB8_RS03640	COG5002	protein histidine kinase activity
LACWKB8_RS03640	COG3850	Histidine kinase
LACWKB8_RS03650	COG1368	sulfuric ester hydrolase activity
LACWKB8_RS03660	COG0166	Belongs to the GPI family
LACWKB8_RS03665	COG0477	Major facilitator Superfamily
LACWKB8_RS03685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACWKB8_RS03745	COG0582	viral genome integration into host DNA
LACWKB8_RS03765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS03770	COG3414	Phosphotransferase system galactitol-specific IIB component
LACWKB8_RS03775	COG3775	system Galactitol-specific IIC component
LACWKB8_RS03780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LACWKB8_RS03790	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS03805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LACWKB8_RS03810	COG1435	thymidine kinase activity
LACWKB8_RS03820	COG2890	protein-(glutamine-N5) methyltransferase activity
LACWKB8_RS03825	COG0009	L-threonylcarbamoyladenylate synthase
LACWKB8_RS03830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LACWKB8_RS03835	COG0356	it plays a direct role in the translocation of protons across the membrane
LACWKB8_RS03840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACWKB8_RS03845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LACWKB8_RS03850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACWKB8_RS03855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LACWKB8_RS03860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LACWKB8_RS03865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LACWKB8_RS03870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LACWKB8_RS03880	COG1077	Cell shape determining protein MreB Mrl
LACWKB8_RS03885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LACWKB8_RS03895	COG0772	Belongs to the SEDS family
LACWKB8_RS03935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LACWKB8_RS03945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LACWKB8_RS03950	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LACWKB8_RS03955	COG1104	cysteine desulfurase activity
LACWKB8_RS03960	COG0301	tRNA thio-modification
LACWKB8_RS03965	COG0525	valine-tRNA ligase activity
LACWKB8_RS03975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACWKB8_RS03980	COG2003	Belongs to the UPF0758 family
LACWKB8_RS03985	COG1077	Cell shape determining protein MreB Mrl
LACWKB8_RS03990	COG1792	Involved in formation and maintenance of cell shape
LACWKB8_RS04005	COG2001	Belongs to the MraZ family
LACWKB8_RS04010	COG0275	rRNA processing
LACWKB8_RS04020	COG0768	penicillin binding
LACWKB8_RS04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LACWKB8_RS04030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LACWKB8_RS04035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LACWKB8_RS04040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LACWKB8_RS04045	COG0849	cell division
LACWKB8_RS04050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LACWKB8_RS04055	COG1799	cell septum assembly
LACWKB8_RS04060	COG0762	integral membrane protein
LACWKB8_RS04075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LACWKB8_RS04080	COG1278	Cold shock
LACWKB8_RS04085	COG0494	nUDIX hydrolase
LACWKB8_RS04095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LACWKB8_RS04100	COG1104	cysteine desulfurase activity
LACWKB8_RS04110	COG0482	sulfurtransferase activity
LACWKB8_RS04115	COG0406	alpha-ribazole phosphatase activity
LACWKB8_RS04125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LACWKB8_RS04145	COG1597	lipid kinase activity
LACWKB8_RS04155	COG5503	Protein of unknown function (DUF1447)
LACWKB8_RS04160	COG0242	peptide deformylase activity
LACWKB8_RS04165	COG1217	gtp-binding protein TYPA
LACWKB8_RS04170	COG0772	Belongs to the SEDS family
LACWKB8_RS04175	COG4471	UPF0298 protein
LACWKB8_RS04180	COG0742	ribosomal rna small subunit methyltransferase
LACWKB8_RS04185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LACWKB8_RS04190	COG3480	Lon protease (S16) C-terminal proteolytic domain
LACWKB8_RS04195	COG1555	photosystem II stabilization
LACWKB8_RS04200	COG0658	competence protein
LACWKB8_RS04200	COG2333	competence protein COMEC
LACWKB8_RS04205	COG1466	dna polymerase III delta subunit
LACWKB8_RS04210	COG0268	Binds directly to 16S ribosomal RNA
LACWKB8_RS04215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LACWKB8_RS04230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LACWKB8_RS04235	COG0544	peptidyl-prolyl cis-trans isomerase activity
LACWKB8_RS04240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LACWKB8_RS04245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LACWKB8_RS04250	COG0322	excinuclease ABC activity
LACWKB8_RS04255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LACWKB8_RS04260	COG2755	lipolytic protein G-D-S-L family
LACWKB8_RS04260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LACWKB8_RS04265	COG1234	tRNA 3'-trailer cleavage
LACWKB8_RS04270	COG0300	oxidoreductase activity
LACWKB8_RS04280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LACWKB8_RS04285	COG0737	Belongs to the 5'-nucleotidase family
LACWKB8_RS04295	COG0587	DNA-directed DNA polymerase activity
LACWKB8_RS04300	COG0205	6-phosphofructokinase activity
LACWKB8_RS04310	COG2996	Protein conserved in bacteria
LACWKB8_RS04320	COG0456	acetyltransferase
LACWKB8_RS04325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LACWKB8_RS04330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LACWKB8_RS04335	COG1187	pseudouridine synthase activity
LACWKB8_RS04340	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LACWKB8_RS04345	COG5632	N-Acetylmuramoyl-L-alanine amidase
LACWKB8_RS04345	COG3409	Peptidoglycan-binding domain 1 protein
LACWKB8_RS04350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LACWKB8_RS04355	COG0539	negative regulation of cytoplasmic translation
LACWKB8_RS04360	COG1160	GTP binding
LACWKB8_RS04375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACWKB8_RS04380	COG0617	tRNA 3'-terminal CCA addition
LACWKB8_RS04385	COG1272	protein, Hemolysin III
LACWKB8_RS04390	COG1307	EDD domain protein, DegV family
LACWKB8_RS04395	COG4479	Belongs to the UPF0346 family
LACWKB8_RS04400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LACWKB8_RS04405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LACWKB8_RS04410	COG0758	DNA mediated transformation
LACWKB8_RS04415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LACWKB8_RS04445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LACWKB8_RS04450	COG0187	DNA topoisomerase II activity
LACWKB8_RS04460	COG0583	DNA-binding transcription factor activity
LACWKB8_RS04465	COG1227	inorganic diphosphatase activity
LACWKB8_RS04475	COG0352	thiamine-phosphate diphosphorylase activity
LACWKB8_RS04495	COG1051	belongs to the nudix hydrolase family
LACWKB8_RS04500	COG1307	EDD domain protein, DegV family
LACWKB8_RS04515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LACWKB8_RS04520	COG0505	Belongs to the CarA family
LACWKB8_RS04525	COG0564	pseudouridine synthase activity
LACWKB8_RS04535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LACWKB8_RS04550	COG0116	Belongs to the methyltransferase superfamily
LACWKB8_RS04555	COG3599	regulation of cell shape
LACWKB8_RS04560	COG4474	Belongs to the UPF0398 family
LACWKB8_RS04565	COG3331	DNA recombination
LACWKB8_RS04570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LACWKB8_RS04580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LACWKB8_RS04590	COG0017	Asparaginyl-tRNA synthetase
LACWKB8_RS04600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LACWKB8_RS04600	COG1199	ATP-dependent helicase activity
LACWKB8_RS04605	COG1074	ATP-dependent DNA helicase activity
LACWKB8_RS04610	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LACWKB8_RS04615	COG0083	homoserine kinase activity
LACWKB8_RS04630	COG1304	FMN binding
LACWKB8_RS04635	COG0561	phosphatase activity
LACWKB8_RS04640	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LACWKB8_RS04640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LACWKB8_RS04675	COG4555	ABC transporter
LACWKB8_RS04680	COG1725	Transcriptional regulator
LACWKB8_RS04700	COG4555	ABC transporter
LACWKB8_RS04705	COG1725	Transcriptional regulator
LACWKB8_RS04720	COG1131	(ABC) transporter
LACWKB8_RS04725	COG2195	Cleaves the N-terminal amino acid of tripeptides
LACWKB8_RS04730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LACWKB8_RS04735	COG2384	SAM-dependent methyltransferase
LACWKB8_RS04740	COG1132	(ABC) transporter
LACWKB8_RS04755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LACWKB8_RS04760	COG0358	DNA primase activity
LACWKB8_RS04765	COG0751	glycine-tRNA ligase activity
LACWKB8_RS04775	COG1381	Involved in DNA repair and RecF pathway recombination
LACWKB8_RS04780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LACWKB8_RS04785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LACWKB8_RS04790	COG1702	phosphate starvation-inducible protein PhoH
LACWKB8_RS04795	COG1610	YqeY-like protein
LACWKB8_RS04800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LACWKB8_RS04805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LACWKB8_RS04810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LACWKB8_RS04815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACWKB8_RS04820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACWKB8_RS04825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACWKB8_RS04830	COG0436	Aminotransferase
LACWKB8_RS04835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LACWKB8_RS04840	COG0494	nUDIX hydrolase
LACWKB8_RS04845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LACWKB8_RS04855	COG1490	D-aminoacyl-tRNA deacylase activity
LACWKB8_RS04860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LACWKB8_RS04870	COG2264	protein methyltransferase activity
LACWKB8_RS04875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LACWKB8_RS04900	COG3052	prosthetic group binding
LACWKB8_RS04915	COG0471	metal ion transport
LACWKB8_RS04920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LACWKB8_RS04925	COG0039	L-malate dehydrogenase activity
LACWKB8_RS04930	COG1053	succinate dehydrogenase
LACWKB8_RS04935	COG0114	fumarate hydratase activity
LACWKB8_RS04940	COG2217	Heavy metal translocating P-type atpase
LACWKB8_RS04945	COG1114	Component of the transport system for branched-chain amino acids
LACWKB8_RS04950	COG1114	Component of the transport system for branched-chain amino acids
LACWKB8_RS04955	COG3142	Participates in the control of copper homeostasis
LACWKB8_RS04960	COG1446	asparaginase
LACWKB8_RS04965	COG0471	metal ion transport
LACWKB8_RS04970	COG3976	FMN-binding domain protein
LACWKB8_RS04970	COG1053	succinate dehydrogenase
LACWKB8_RS04975	COG1053	succinate dehydrogenase
LACWKB8_RS04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LACWKB8_RS04990	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LACWKB8_RS04995	COG1461	Dihydroxyacetone kinase
LACWKB8_RS05000	COG2376	Dihydroxyacetone kinase
LACWKB8_RS05025	COG2011	ABC-type metal ion transport system permease component
LACWKB8_RS05030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LACWKB8_RS05075	COG0789	Transcriptional regulator
LACWKB8_RS05105	COG1620	l-lactate permease
LACWKB8_RS05110	COG1307	EDD domain protein, DegV family
LACWKB8_RS05115	COG0148	phosphopyruvate hydratase activity
LACWKB8_RS05135	COG0667	Aldo Keto reductase
LACWKB8_RS05140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LACWKB8_RS05145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LACWKB8_RS05145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LACWKB8_RS05150	COG0481	GTPase activity
LACWKB8_RS05155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACWKB8_RS05165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS05170	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS05180	COG3711	transcriptional antiterminator
LACWKB8_RS05180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS05185	COG0484	heat shock protein binding
LACWKB8_RS05190	COG0443	Heat shock 70 kDa protein
LACWKB8_RS05195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LACWKB8_RS05200	COG1420	regulation of RNA biosynthetic process
LACWKB8_RS05205	COG0196	riboflavin kinase activity
LACWKB8_RS05210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LACWKB8_RS05215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LACWKB8_RS05220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LACWKB8_RS05230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LACWKB8_RS05235	COG0195	Participates in both transcription termination and antitermination
LACWKB8_RS05240	COG0779	Required for maturation of 30S ribosomal subunits
LACWKB8_RS05250	COG0442	prolyl-tRNA aminoacylation
LACWKB8_RS05255	COG0750	zinc metalloprotease
LACWKB8_RS05260	COG4589	Belongs to the CDS family
LACWKB8_RS05265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LACWKB8_RS05270	COG0233	cytoplasmic translational termination
LACWKB8_RS05275	COG0528	UMP kinase activity
LACWKB8_RS05305	COG0052	Belongs to the universal ribosomal protein uS2 family
LACWKB8_RS05310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LACWKB8_RS05315	COG0204	Acyl-transferase
LACWKB8_RS05320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LACWKB8_RS05325	COG0277	FAD linked oxidase domain protein
LACWKB8_RS05330	COG1132	(ABC) transporter
LACWKB8_RS05335	COG1132	(ABC) transporter
LACWKB8_RS05340	COG3763	UPF0154 protein
LACWKB8_RS05345	COG4224	UPF0291 protein
LACWKB8_RS05350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LACWKB8_RS05375	COG0336	Belongs to the RNA methyltransferase TrmD family
LACWKB8_RS05380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LACWKB8_RS05390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LACWKB8_RS05395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LACWKB8_RS05400	COG0531	amino acid
LACWKB8_RS05405	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS05410	COG2190	(PTS) system
LACWKB8_RS05410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS05410	COG1263	PTS System
LACWKB8_RS05415	COG3711	transcriptional antiterminator
LACWKB8_RS05425	COG0552	protein localization to endoplasmic reticulum
LACWKB8_RS05430	COG1196	nuclear chromosome segregation
LACWKB8_RS05435	COG0571	ribonuclease III activity
LACWKB8_RS05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LACWKB8_RS05460	COG0601	transmembrane transport
LACWKB8_RS05465	COG4608	Belongs to the ABC transporter superfamily
LACWKB8_RS05475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACWKB8_RS05480	COG0416	fatty acid biosynthetic process
LACWKB8_RS05485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LACWKB8_RS05490	COG1461	Dihydroxyacetone kinase
LACWKB8_RS05500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LACWKB8_RS05510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LACWKB8_RS05515	COG1162	GTPase activity
LACWKB8_RS05520	COG2815	serine threonine protein kinase
LACWKB8_RS05520	COG0515	serine threonine protein kinase
LACWKB8_RS05530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LACWKB8_RS05530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LACWKB8_RS05535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LACWKB8_RS05540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LACWKB8_RS05545	COG1758	RNA polymerase activity
LACWKB8_RS05550	COG0194	GDP metabolic process
LACWKB8_RS05565	COG0497	DNA recombination
LACWKB8_RS05570	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LACWKB8_RS05580	COG1722	exodeoxyribonuclease VII activity
LACWKB8_RS05585	COG1570	exodeoxyribonuclease VII activity
LACWKB8_RS05590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LACWKB8_RS05595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LACWKB8_RS05600	COG1302	Protein conserved in bacteria
LACWKB8_RS05605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LACWKB8_RS05610	COG0006	proline dipeptidase activity
LACWKB8_RS05615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LACWKB8_RS05620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LACWKB8_RS05625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACWKB8_RS05660	COG2936	dipeptidyl-peptidase activity
LACWKB8_RS05665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LACWKB8_RS05670	COG0505	Belongs to the CarA family
LACWKB8_RS05675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACWKB8_RS05680	COG0540	Belongs to the ATCase OTCase family
LACWKB8_RS05690	COG0167	dihydroorotate dehydrogenase activity
LACWKB8_RS05700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LACWKB8_RS05715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LACWKB8_RS05735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LACWKB8_RS05740	COG0768	penicillin binding
LACWKB8_RS05745	COG2971	BadF BadG BcrA BcrD
LACWKB8_RS05755	COG0072	phenylalanine-tRNA ligase activity
LACWKB8_RS05760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LACWKB8_RS05765	COG1733	regulation of RNA biosynthetic process
LACWKB8_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACWKB8_RS05775	COG1254	Belongs to the acylphosphatase family
LACWKB8_RS05780	COG0706	membrane insertase activity
LACWKB8_RS05785	COG5002	protein histidine kinase activity
LACWKB8_RS05790	COG0745	RESPONSE REGULATOR receiver
LACWKB8_RS05800	COG1323	Belongs to the UPF0348 family
LACWKB8_RS05805	COG0799	negative regulation of ribosome biogenesis
LACWKB8_RS05810	COG1713	HD superfamily hydrolase involved in NAD metabolism
LACWKB8_RS05815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LACWKB8_RS05820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LACWKB8_RS05830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LACWKB8_RS05840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LACWKB8_RS05845	COG0765	amino acid transport
LACWKB8_RS05850	COG0765	amino acid transport
LACWKB8_RS05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACWKB8_RS05865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LACWKB8_RS05870	COG1484	DNA-dependent DNA replication
LACWKB8_RS05880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LACWKB8_RS05885	COG0237	dephospho-CoA kinase activity
LACWKB8_RS05890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LACWKB8_RS05895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACWKB8_RS05895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACWKB8_RS05900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LACWKB8_RS05905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACWKB8_RS05910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LACWKB8_RS05915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LACWKB8_RS05920	COG4473	ABC transporter
LACWKB8_RS05925	COG1131	(ABC) transporter
LACWKB8_RS05930	COG0537	adenosine 5'-monophosphoramidase activity
LACWKB8_RS05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LACWKB8_RS05945	COG3481	metal-dependent phosphohydrolase, HD sub domain
LACWKB8_RS05950	COG4717	serine-type aminopeptidase activity
LACWKB8_RS05955	COG0420	3'-5' exonuclease activity
LACWKB8_RS05960	COG3679	Belongs to the UPF0342 family
LACWKB8_RS05965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LACWKB8_RS05970	COG0564	pseudouridine synthase activity
LACWKB8_RS05975	COG2267	carboxylic ester hydrolase activity
LACWKB8_RS06005	COG0018	arginyl-trna synthetase
LACWKB8_RS06010	COG1376	ErfK ybiS ycfS ynhG family protein
LACWKB8_RS06015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LACWKB8_RS06020	COG1686	Belongs to the peptidase S11 family
LACWKB8_RS06035	COG2244	polysaccharide biosynthetic process
LACWKB8_RS06040	COG0495	leucyl-tRNA aminoacylation
LACWKB8_RS06055	COG2365	Tyrosine phosphatase family
LACWKB8_RS06060	COG2814	Major facilitator Superfamily
LACWKB8_RS06065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LACWKB8_RS06160	COG0513	Belongs to the DEAD box helicase family
LACWKB8_RS06165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LACWKB8_RS06170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACWKB8_RS06175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LACWKB8_RS06180	COG1862	Preprotein translocase
LACWKB8_RS06185	COG2255	four-way junction helicase activity
LACWKB8_RS06190	COG0632	four-way junction helicase activity
LACWKB8_RS06195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LACWKB8_RS06200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LACWKB8_RS06220	COG0459	protein refolding
LACWKB8_RS06225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LACWKB8_RS06230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LACWKB8_RS06235	COG0488	(ABC) transporter
LACWKB8_RS06275	COG1162	GTPase activity
LACWKB8_RS06295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LACWKB8_RS06305	COG1214	PFAM Peptidase M22, glycoprotease
LACWKB8_RS06310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LACWKB8_RS06330	COG0470	DNA polymerase III
LACWKB8_RS06335	COG3870	Protein conserved in bacteria
LACWKB8_RS06340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LACWKB8_RS06350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LACWKB8_RS06355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LACWKB8_RS06360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LACWKB8_RS06365	COG0590	tRNA wobble adenosine to inosine editing
LACWKB8_RS06370	COG2813	Specifically methylates the guanine in position
LACWKB8_RS06390	COG0222	ribosome binding
LACWKB8_RS06395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LACWKB8_RS06400	COG0704	Plays a role in the regulation of phosphate uptake
LACWKB8_RS06405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LACWKB8_RS06410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LACWKB8_RS06415	COG0581	inorganic phosphate transmembrane transporter activity
LACWKB8_RS06420	COG0573	inorganic phosphate transmembrane transporter activity
LACWKB8_RS06430	COG0081	regulation of translation
LACWKB8_RS06435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LACWKB8_RS06440	COG0250	Participates in transcription elongation, termination and antitermination
LACWKB8_RS06445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LACWKB8_RS06460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACWKB8_RS06465	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LACWKB8_RS06480	COG0215	cysteine-tRNA ligase activity
LACWKB8_RS06485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LACWKB8_RS06495	COG0756	dUTP diphosphatase activity
LACWKB8_RS06525	COG0588	phosphoglycerate mutase activity
LACWKB8_RS06535	COG0588	phosphoglycerate mutase activity
LACWKB8_RS06545	COG0640	Transcriptional regulator
LACWKB8_RS06565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACWKB8_RS06570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS06575	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS06590	COG0383	alpha-mannosidase activity
LACWKB8_RS06595	COG0383	alpha-mannosidase activity
LACWKB8_RS06600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACWKB8_RS06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS06600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACWKB8_RS06605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACWKB8_RS06630	COG1136	(ABC) transporter
LACWKB8_RS06635	COG1136	(ABC) transporter
LACWKB8_RS06635	COG0577	efflux transmembrane transporter activity
LACWKB8_RS06645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LACWKB8_RS06650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LACWKB8_RS06655	COG0101	tRNA pseudouridine synthase activity
LACWKB8_RS06660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LACWKB8_RS06665	COG1122	ATPase activity
LACWKB8_RS06675	COG0203	ribosomal protein L17
LACWKB8_RS06680	COG0202	RNA polymerase activity
LACWKB8_RS06685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LACWKB8_RS06690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LACWKB8_RS06700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LACWKB8_RS06705	COG0563	adenylate kinase activity
LACWKB8_RS06715	COG0200	Binds to the 23S rRNA
LACWKB8_RS06720	COG1841	ribosomal large subunit assembly
LACWKB8_RS06725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LACWKB8_RS06735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LACWKB8_RS06740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LACWKB8_RS06750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LACWKB8_RS06755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LACWKB8_RS06760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LACWKB8_RS06770	COG0255	Belongs to the universal ribosomal protein uL29 family
LACWKB8_RS06775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LACWKB8_RS06780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LACWKB8_RS06785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LACWKB8_RS06795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LACWKB8_RS06800	COG0089	rRNA binding
LACWKB8_RS06810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LACWKB8_RS06815	COG0051	transcription antitermination factor activity, RNA binding
LACWKB8_RS06820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LACWKB8_RS06825	COG0049	tRNA binding
LACWKB8_RS06830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LACWKB8_RS06840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LACWKB8_RS06845	COG0085	RNA polymerase activity
LACWKB8_RS06850	COG0542	response to heat
LACWKB8_RS06875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LACWKB8_RS06880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LACWKB8_RS06890	COG1132	(ABC) transporter
LACWKB8_RS06895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LACWKB8_RS06920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LACWKB8_RS06925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LACWKB8_RS06930	COG0193	aminoacyl-tRNA hydrolase activity
LACWKB8_RS06940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LACWKB8_RS06945	COG0736	holo-[acyl-carrier-protein] synthase activity
LACWKB8_RS06955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LACWKB8_RS06960	COG0254	rRNA binding
LACWKB8_RS06970	COG1126	abc transporter atp-binding protein
LACWKB8_RS06975	COG0765	amino acid transport
LACWKB8_RS06980	COG0765	amino acid transport
LACWKB8_RS06985	COG1737	Transcriptional regulator
LACWKB8_RS06990	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS06995	COG1263	PTS System
LACWKB8_RS06995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS07010	COG0531	amino acid
LACWKB8_RS07045	COG2274	protein secretion by the type I secretion system
LACWKB8_RS07050	COG1132	(ABC) transporter
LACWKB8_RS07060	COG3527	Alpha-acetolactate decarboxylase
LACWKB8_RS07065	COG0519	Catalyzes the synthesis of GMP from XMP
LACWKB8_RS07075	COG2233	PERMEase
LACWKB8_RS07090	COG4690	dipeptidase activity
LACWKB8_RS07110	COG3711	transcriptional antiterminator
LACWKB8_RS07115	COG1940	carbohydrate kinase activity
LACWKB8_RS07125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LACWKB8_RS07130	COG0504	CTP synthase activity
LACWKB8_RS07135	COG3343	RNA polymerase activity
LACWKB8_RS07150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LACWKB8_RS07155	COG0439	Biotin carboxylase
LACWKB8_RS07160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LACWKB8_RS07170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LACWKB8_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS07190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACWKB8_RS07210	COG1132	(ABC) transporter
LACWKB8_RS07220	COG1078	dGTPase activity
LACWKB8_RS07225	COG1132	(ABC) transporter
LACWKB8_RS07230	COG3842	ATPase activity
LACWKB8_RS07235	COG1132	(ABC) transporter
LACWKB8_RS07240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LACWKB8_RS07250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS07250	COG1263	PTS System
LACWKB8_RS07255	COG2382	esterase
LACWKB8_RS07255	COG3693	PFAM glycoside hydrolase, family 10
LACWKB8_RS07255	COG3507	Belongs to the glycosyl hydrolase 43 family
LACWKB8_RS07270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS07290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LACWKB8_RS07295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LACWKB8_RS07300	COG4466	Protein conserved in bacteria
LACWKB8_RS07305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LACWKB8_RS07315	COG0084	hydrolase, TatD family'
LACWKB8_RS07320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACWKB8_RS07320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACWKB8_RS07335	COG2131	deaminase
LACWKB8_RS07375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACWKB8_RS07380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LACWKB8_RS07390	COG3579	cysteine-type endopeptidase activity
LACWKB8_RS07395	COG1957	nucleoside hydrolase
LACWKB8_RS07400	COG1079	Belongs to the binding-protein-dependent transport system permease family
LACWKB8_RS07405	COG4603	Belongs to the binding-protein-dependent transport system permease family
LACWKB8_RS07410	COG3845	ABC transporter
LACWKB8_RS07415	COG1744	ABC transporter substrate-binding protein PnrA-like
LACWKB8_RS07420	COG1744	ABC transporter substrate-binding protein PnrA-like
LACWKB8_RS07430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LACWKB8_RS07435	COG1418	mRNA catabolic process
LACWKB8_RS07450	COG0393	Putative heavy-metal-binding
LACWKB8_RS07455	COG0494	nUDIX hydrolase
LACWKB8_RS07460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LACWKB8_RS07465	COG1368	sulfuric ester hydrolase activity
LACWKB8_RS07470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LACWKB8_RS07475	COG1316	TRANSCRIPTIONal
LACWKB8_RS07490	COG2814	Major facilitator Superfamily
LACWKB8_RS07510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LACWKB8_RS07515	COG0791	NLP P60 protein
LACWKB8_RS07520	COG0791	NLP P60 protein
LACWKB8_RS07525	COG0791	NLP P60 protein
LACWKB8_RS07530	COG0194	GDP metabolic process
LACWKB8_RS07560	COG4990	cell redox homeostasis
LACWKB8_RS07570	COG2966	Psort location CytoplasmicMembrane, score
LACWKB8_RS07575	COG0488	(ABC) transporter
LACWKB8_RS07585	COG1316	TRANSCRIPTIONal
LACWKB8_RS07590	COG1164	Oligoendopeptidase f
LACWKB8_RS07595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LACWKB8_RS07600	COG1126	abc transporter atp-binding protein
LACWKB8_RS07605	COG0765	amino acid transport
LACWKB8_RS07610	COG1304	FMN binding
LACWKB8_RS07615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LACWKB8_RS07630	COG0803	Belongs to the bacterial solute-binding protein 9 family
LACWKB8_RS07635	COG1346	cytolysis
LACWKB8_RS07645	COG3279	Response regulator of the LytR AlgR family
LACWKB8_RS07650	COG3275	phosphorelay sensor kinase activity
LACWKB8_RS07655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACWKB8_RS07655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACWKB8_RS07655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS07660	COG1105	Belongs to the carbohydrate kinase PfkB family
LACWKB8_RS07665	COG1349	DNA-binding transcription factor activity
LACWKB8_RS07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LACWKB8_RS07680	COG1053	succinate dehydrogenase
LACWKB8_RS07685	COG3976	FMN-binding domain protein
LACWKB8_RS07685	COG1053	succinate dehydrogenase
LACWKB8_RS07695	COG1053	succinate dehydrogenase
LACWKB8_RS07700	COG0583	DNA-binding transcription factor activity
LACWKB8_RS07715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LACWKB8_RS07725	COG1309	transcriptional regulator
LACWKB8_RS07730	COG0481	GTPase activity
LACWKB8_RS07735	COG0588	phosphoglycerate mutase activity
LACWKB8_RS07760	COG0673	inositol 2-dehydrogenase activity
LACWKB8_RS07770	COG0475	glutathione-regulated potassium exporter activity
LACWKB8_RS07770	COG0569	domain protein
LACWKB8_RS07780	COG1705	Flagellar rod assembly protein muramidase FlgJ
LACWKB8_RS07780	COG1388	LysM domain
LACWKB8_RS07820	COG3158	transport of potassium into the cell
LACWKB8_RS07835	COG3590	peptidase
LACWKB8_RS07840	COG2814	Major facilitator Superfamily
LACWKB8_RS07860	COG0367	asparagine synthase
LACWKB8_RS07875	COG0519	Catalyzes the synthesis of GMP from XMP
LACWKB8_RS07885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LACWKB8_RS07885	COG0517	IMP dehydrogenase activity
LACWKB8_RS07890	COG3414	Phosphotransferase system galactitol-specific IIB component
LACWKB8_RS07895	COG3775	system Galactitol-specific IIC component
LACWKB8_RS07930	COG3639	organic phosphonate transmembrane transporter activity
LACWKB8_RS07940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LACWKB8_RS07955	COG0589	response to stress
LACWKB8_RS07960	COG2365	Tyrosine phosphatase family
LACWKB8_RS07970	COG0519	Catalyzes the synthesis of GMP from XMP
LACWKB8_RS07970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LACWKB8_RS07975	COG1132	(ABC) transporter
LACWKB8_RS07980	COG2814	Major facilitator Superfamily
LACWKB8_RS08015	COG0446	pyridine nucleotide-disulphide oxidoreductase
LACWKB8_RS08025	COG1132	(ABC) transporter
LACWKB8_RS08045	COG1131	(ABC) transporter
LACWKB8_RS08060	COG1132	(ABC) transporter
LACWKB8_RS08105	COG2801	Transposase and inactivated derivatives
LACWKB8_RS08110	COG1132	(ABC) transporter
LACWKB8_RS08125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LACWKB8_RS08130	COG2249	NAD(P)H dehydrogenase (quinone) activity
LACWKB8_RS08135	COG0156	8-amino-7-oxononanoate synthase activity
LACWKB8_RS08145	COG2801	Transposase and inactivated derivatives
LACWKB8_RS08150	COG3177	Filamentation induced by cAMP protein fic
LACWKB8_RS08185	COG0583	DNA-binding transcription factor activity
LACWKB8_RS08195	COG1053	succinate dehydrogenase
LACWKB8_RS08200	COG2723	6-phospho-beta-galactosidase activity
LACWKB8_RS08205	COG1263	PTS System
LACWKB8_RS08205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS08205	COG2190	(PTS) system
LACWKB8_RS08265	COG1132	(ABC) transporter
LACWKB8_RS08270	COG1609	Transcriptional regulator
LACWKB8_RS08275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LACWKB8_RS08280	COG3716	PTS system mannose fructose sorbose family IID component
LACWKB8_RS08290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACWKB8_RS08290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS08295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LACWKB8_RS08310	COG1609	Transcriptional regulator
LACWKB8_RS08315	COG1879	ABC-type sugar transport system periplasmic component
LACWKB8_RS08320	COG1172	Belongs to the binding-protein-dependent transport system permease family
LACWKB8_RS08330	COG1869	D-ribose catabolic process
LACWKB8_RS08345	COG1609	Transcriptional regulator
LACWKB8_RS08350	COG3959	Transketolase, thiamine diphosphate binding domain
LACWKB8_RS08355	COG3958	Transketolase
LACWKB8_RS08360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LACWKB8_RS08365	COG2197	response regulator
LACWKB8_RS08370	COG1228	amidohydrolase
LACWKB8_RS08380	COG2365	Tyrosine phosphatase family
LACWKB8_RS08385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LACWKB8_RS08390	COG0351	phosphomethylpyrimidine kinase
LACWKB8_RS08395	COG3442	glutamine amidotransferase
LACWKB8_RS08400	COG1609	Transcriptional regulator
LACWKB8_RS08410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS08420	COG1447	Phosphotransferase system cellobiose-specific component IIA
LACWKB8_RS08440	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LACWKB8_RS08445	COG0351	phosphomethylpyrimidine kinase
LACWKB8_RS08450	COG0352	thiamine-phosphate diphosphorylase activity
LACWKB8_RS08495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LACWKB8_RS08500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LACWKB8_RS08505	COG0516	GMP reductase activity
LACWKB8_RS08515	COG0800	Aldolase
LACWKB8_RS08520	COG1609	Transcriptional regulator
LACWKB8_RS08525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LACWKB8_RS08530	COG0436	Aminotransferase
LACWKB8_RS08535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LACWKB8_RS08540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LACWKB8_RS08545	COG1473	amidohydrolase
LACWKB8_RS08550	COG2171	N-acyltransferase activity
LACWKB8_RS08555	COG0019	diaminopimelate decarboxylase activity
LACWKB8_RS08560	COG0527	aspartate kinase activity
LACWKB8_RS08565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LACWKB8_RS08590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LACWKB8_RS08595	COG0488	(ABC) transporter
LACWKB8_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
LACWKB8_RS08620	COG3152	Membrane
LACWKB8_RS08650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LACWKB8_RS08660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACWKB8_RS08675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LACWKB8_RS08680	COG1162	GTPase activity
LACWKB8_RS08685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LACWKB8_RS08690	COG0542	response to heat
LACWKB8_RS08695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACWKB8_RS08705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACWKB8_RS08720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACWKB8_RS08725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LACWKB8_RS08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACWKB8_RS08735	COG1696	Membrane protein involved in D-alanine export
LACWKB8_RS08740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LACWKB8_RS08765	COG2217	Heavy metal translocating P-type atpase
LACWKB8_RS08780	COG1136	(ABC) transporter
LACWKB8_RS08780	COG1136	(ABC) transporter
LACWKB8_RS08780	COG0577	efflux transmembrane transporter activity
LACWKB8_RS08780	COG0577	efflux transmembrane transporter activity
LACWKB8_RS08785	COG0363	glucosamine-6-phosphate deaminase activity
LACWKB8_RS08805	COG1132	(ABC) transporter
LACWKB8_RS08810	COG1428	Deoxynucleoside kinase
LACWKB8_RS08815	COG1428	Deoxynucleoside kinase
LACWKB8_RS08820	COG0765	amino acid transport
LACWKB8_RS08825	COG1126	abc transporter atp-binding protein
LACWKB8_RS08830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACWKB8_RS08835	COG0561	phosphatase activity
LACWKB8_RS08840	COG2252	PERMEase
LACWKB8_RS08845	COG2252	PERMEase
LACWKB8_RS08855	COG2814	Major facilitator Superfamily
LACWKB8_RS08860	COG0038	chloride channel
LACWKB8_RS08865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LACWKB8_RS08870	COG0028	Belongs to the TPP enzyme family
LACWKB8_RS08875	COG0445	tRNA wobble uridine modification
LACWKB8_RS08880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LACWKB8_RS08885	COG0706	membrane insertase activity
LACWKB8_RS08890	COG0594	ribonuclease P activity
LACWKB8_RS08895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LACWKB8_RS08905	COG1136	(ABC) transporter
LACWKB8_RS08935	COG2755	lipolytic protein G-D-S-L family