locus-tag	class	description
HG420_RS00005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG420_RS00015	COG0077	Prephenate dehydratase
HG420_RS00030	COG0287	Prephenate dehydrogenase
HG420_RS00040	COG0745	RESPONSE REGULATOR receiver
HG420_RS00050	COG0577	efflux transmembrane transporter activity
HG420_RS00055	COG1136	(ABC) transporter
HG420_RS00075	COG4493	Belongs to the UPF0637 family
HG420_RS00100	COG0765	amino acid transport
HG420_RS00105	COG1126	abc transporter atp-binding protein
HG420_RS00140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG420_RS00150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG420_RS00160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG420_RS00165	COG0356	it plays a direct role in the translocation of protons across the membrane
HG420_RS00205	COG4152	abc transporter atp-binding protein
HG420_RS00225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG420_RS00240	COG1268	BioY protein
HG420_RS00260	COG4842	Belongs to the WXG100 family
HG420_RS00265	COG0719	Fe-S assembly protein
HG420_RS00280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG420_RS00285	COG0719	Fe-S assembly protein
HG420_RS00295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG420_RS00300	COG4862	establishment of competence for transformation
HG420_RS00305	COG1126	abc transporter atp-binding protein
HG420_RS00310	COG0765	amino acid transport
HG420_RS00315	COG0085	RNA polymerase activity
HG420_RS00335	COG1396	sequence-specific DNA binding
HG420_RS00340	COG3590	peptidase
HG420_RS00350	COG2244	polysaccharide biosynthetic process
HG420_RS00365	COG1064	alcohol dehydrogenase
HG420_RS00370	COG0514	ATP-dependent DNA helicase (RecQ)
HG420_RS00385	COG2195	Cleaves the N-terminal amino acid of tripeptides
HG420_RS00395	COG1227	inorganic diphosphatase activity
HG420_RS00400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HG420_RS00405	COG1253	flavin adenine dinucleotide binding
HG420_RS00410	COG0628	permease
HG420_RS00440	COG1573	uracil-dna glycosylase
HG420_RS00445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG420_RS00455	COG2827	Endonuclease containing a URI domain
HG420_RS00460	COG1113	amino acid transport
HG420_RS00470	COG1564	THIamine pyrophosphokinase
HG420_RS00500	COG0436	Aminotransferase
HG420_RS00510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HG420_RS00510	COG1199	ATP-dependent helicase activity
HG420_RS00525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG420_RS00530	COG0601	transmembrane transport
HG420_RS00535	COG4608	Belongs to the ABC transporter superfamily
HG420_RS00540	COG0444	Belongs to the ABC transporter superfamily
HG420_RS00545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG420_RS00550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG420_RS00555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG420_RS00590	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HG420_RS00605	COG1045	serine acetyltransferase
HG420_RS00625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG420_RS00630	COG0589	response to stress
HG420_RS00635	COG1104	cysteine desulfurase activity
HG420_RS00645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG420_RS00660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG420_RS00665	COG3599	regulation of cell shape
HG420_RS00670	COG2302	S4 RNA-binding domain
HG420_RS00685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG420_RS00690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG420_RS00695	COG0849	cell division
HG420_RS00700	COG1307	EDD domain protein, DegV family
HG420_RS00715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG420_RS00720	COG0656	L-ascorbic acid biosynthetic process
HG420_RS00755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG420_RS00765	COG0494	nUDIX hydrolase
HG420_RS00775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG420_RS00780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG420_RS00785	COG2815	serine threonine protein kinase
HG420_RS00785	COG0515	serine threonine protein kinase
HG420_RS00790	COG0631	protein serine/threonine phosphatase activity
HG420_RS00795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG420_RS00795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG420_RS00805	COG0463	Glycosyl transferase, family 2
HG420_RS00825	COG0756	dUTP diphosphatase activity
HG420_RS00885	COG2261	transglycosylase associated protein
HG420_RS00915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG420_RS00920	COG1758	RNA polymerase activity
HG420_RS00925	COG0194	GDP metabolic process
HG420_RS00935	COG0363	glucosamine-6-phosphate deaminase activity
HG420_RS00945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG420_RS00950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG420_RS00950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG420_RS00970	COG3942	CHAP domain
HG420_RS00970	COG1705	Flagellar rod assembly protein muramidase FlgJ
HG420_RS00975	COG0191	fructose-bisphosphate aldolase activity
HG420_RS01035	COG2860	membrane
HG420_RS01060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG420_RS01070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HG420_RS01075	COG0626	cystathionine gamma-synthase activity
HG420_RS01080	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HG420_RS01100	COG3481	metal-dependent phosphohydrolase, HD sub domain
HG420_RS01125	COG1162	GTPase activity
HG420_RS01130	COG1388	LysM domain
HG420_RS01130	COG3584	3D domain protein
HG420_RS01135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG420_RS01135	COG0072	phenylalanine-tRNA ligase activity
HG420_RS01145	COG3479	Phenolic acid decarboxylase
HG420_RS01160	COG3469	chitinase activity
HG420_RS01165	COG3397	chitin binding
HG420_RS01230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG420_RS01240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG420_RS01245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG420_RS01250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG420_RS01260	COG0537	adenosine 5'-monophosphoramidase activity
HG420_RS01285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG420_RS01290	COG1426	Protein conserved in bacteria
HG420_RS01295	COG0612	Peptidase, M16
HG420_RS01300	COG0612	Peptidase, M16
HG420_RS01305	COG2501	S4 domain
HG420_RS01315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HG420_RS01330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG420_RS01340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HG420_RS01380	COG0826	peptidase U32
HG420_RS01395	COG0500	methyltransferase
HG420_RS01410	COG1131	(ABC) transporter
HG420_RS01430	COG0537	adenosine 5'-monophosphoramidase activity
HG420_RS01445	COG0081	regulation of translation
HG420_RS01450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG420_RS01460	COG1131	(ABC) transporter
HG420_RS01465	COG4479	Belongs to the UPF0346 family
HG420_RS01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG420_RS01475	COG2996	Protein conserved in bacteria
HG420_RS01500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HG420_RS01505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HG420_RS01510	COG0827	DNA restriction-modification system
HG420_RS01520	COG1217	gtp-binding protein TYPA
HG420_RS01555	COG1940	carbohydrate kinase activity
HG420_RS01565	COG0783	Belongs to the Dps family
HG420_RS01595	COG0531	amino acid
HG420_RS01615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG420_RS01620	COG2235	arginine
HG420_RS01640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG420_RS01650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG420_RS01665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HG420_RS01685	COG1266	CAAX protease self-immunity
HG420_RS01700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG420_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG420_RS01710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG420_RS01725	COG1335	isochorismatase
HG420_RS01765	COG4956	integral membrane protein (PIN domain superfamily)
HG420_RS01785	COG1216	Glycosyl transferase, family 2
HG420_RS01785	COG1442	glycosyl transferase family 8
HG420_RS01790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG420_RS01795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HG420_RS01815	COG1216	Glycosyl transferase, family 2
HG420_RS01820	COG1216	Glycosyl transferase, family 2
HG420_RS01835	COG0203	ribosomal protein L17
HG420_RS01840	COG0202	RNA polymerase activity
HG420_RS01845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG420_RS01850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG420_RS01855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG420_RS01860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG420_RS01865	COG0563	adenylate kinase activity
HG420_RS01875	COG0200	Binds to the 23S rRNA
HG420_RS01880	COG1841	ribosomal large subunit assembly
HG420_RS01885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG420_RS01890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG420_RS01900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG420_RS01910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG420_RS01915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG420_RS01920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG420_RS01925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG420_RS01930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG420_RS01935	COG0255	Belongs to the universal ribosomal protein uL29 family
HG420_RS01940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG420_RS01945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG420_RS01950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG420_RS01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG420_RS01960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG420_RS01975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG420_RS01980	COG0051	transcription antitermination factor activity, RNA binding
HG420_RS01990	COG1970	mechanosensitive ion channel activity
HG420_RS02005	COG0250	Participates in transcription elongation, termination and antitermination
HG420_RS02015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG420_RS02020	COG2755	lipolytic protein G-D-S-L family
HG420_RS02020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG420_RS02025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG420_RS02030	COG2323	membrane
HG420_RS02045	COG0564	pseudouridine synthase activity
HG420_RS02055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG420_RS02060	COG1121	(ABC) transporter
HG420_RS02065	COG3443	Belongs to the bacterial solute-binding protein 9 family
HG420_RS02065	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG420_RS02070	COG1846	Transcriptional regulator
HG420_RS02095	COG4537	Required for transformation and DNA binding
HG420_RS02100	COG1459	type II secretion system
HG420_RS02105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG420_RS02110	COG2176	DNA-directed DNA polymerase activity
HG420_RS02125	COG0442	prolyl-tRNA aminoacylation
HG420_RS02130	COG0750	zinc metalloprotease
HG420_RS02135	COG4589	Belongs to the CDS family
HG420_RS02140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG420_RS02145	COG1862	Preprotein translocase
HG420_RS02160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG420_RS02170	COG0438	transferase activity, transferring glycosyl groups
HG420_RS02185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG420_RS02190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG420_RS02190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG420_RS02200	COG1609	Transcriptional regulator
HG420_RS02230	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HG420_RS02235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG420_RS02240	COG0052	Belongs to the universal ribosomal protein uS2 family
HG420_RS02250	COG2706	6-phosphogluconolactonase activity
HG420_RS02255	COG1454	alcohol dehydrogenase
HG420_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
HG420_RS02280	COG0535	radical SAM domain protein
HG420_RS02290	COG3480	Lon protease (S16) C-terminal proteolytic domain
HG420_RS02300	COG0742	ribosomal rna small subunit methyltransferase
HG420_RS02305	COG2814	Major facilitator Superfamily
HG420_RS02345	COG0702	epimerase
HG420_RS02350	COG1733	regulation of RNA biosynthetic process
HG420_RS02355	COG0525	valine-tRNA ligase activity
HG420_RS02390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG420_RS02430	COG1070	Carbohydrate kinase
HG420_RS02435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HG420_RS02450	COG1408	metallophosphoesterase
HG420_RS02455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG420_RS02460	COG0629	single-stranded DNA binding
HG420_RS02465	COG0360	Binds together with S18 to 16S ribosomal RNA
HG420_RS02475	COG0833	amino acid
HG420_RS02480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG420_RS02490	COG1956	GAF domain-containing protein
HG420_RS02495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG420_RS02495	COG1605	Chorismate mutase
HG420_RS02510	COG0174	glutamine synthetase
HG420_RS02515	COG0789	Transcriptional regulator
HG420_RS02520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG420_RS02525	COG2255	four-way junction helicase activity
HG420_RS02575	COG0730	response to heat
HG420_RS02585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG420_RS02590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HG420_RS02605	COG1794	racemase activity, acting on amino acids and derivatives
HG420_RS02615	COG0367	asparagine synthase
HG420_RS02620	COG3942	CHAP domain
HG420_RS02620	COG3883	PFAM NLP P60 protein
HG420_RS02635	COG0494	nUDIX hydrolase
HG420_RS02645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG420_RS02650	COG2814	Major facilitator Superfamily
HG420_RS02655	COG0589	response to stress
HG420_RS02670	COG1309	transcriptional regulator
HG420_RS02675	COG1187	pseudouridine synthase activity
HG420_RS02710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG420_RS02715	COG2824	Alkylphosphonate utilization operon protein PhnA
HG420_RS02745	COG1266	CAAX protease self-immunity
HG420_RS02805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG420_RS02810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG420_RS02820	COG1136	(ABC) transporter
HG420_RS02830	COG0681	Belongs to the peptidase S26 family
HG420_RS02835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG420_RS02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG420_RS02865	COG0049	tRNA binding
HG420_RS02870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG420_RS02885	COG1686	Belongs to the peptidase S11 family
HG420_RS02890	COG4975	Glucose uptake
HG420_RS02895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HG420_RS02900	COG1242	4 iron, 4 sulfur cluster binding
HG420_RS02935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG420_RS02940	COG0592	DNA-directed DNA polymerase activity
HG420_RS02965	COG0012	GTP binding
HG420_RS02985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG420_RS02990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG420_RS03010	COG0037	tRNA processing
HG420_RS03015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HG420_RS03020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG420_RS03065	COG2213	PTS system mannitol-specific
HG420_RS03085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG420_RS03105	COG0659	secondary active sulfate transmembrane transporter activity
HG420_RS03110	COG3153	acetyltransferase
HG420_RS03120	COG0436	Aminotransferase
HG420_RS03135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG420_RS03150	COG0095	Lipoate-protein ligase
HG420_RS03155	COG0584	glycerophosphoryl diester phosphodiesterase
HG420_RS03160	COG1418	mRNA catabolic process
HG420_RS03175	COG0180	Tryptophanyl-tRNA synthetase
HG420_RS03180	COG1764	response to oxidative stress
HG420_RS03200	COG0488	(ABC) transporter
HG420_RS03210	COG4221	oxidoreductase activity
HG420_RS03215	COG1309	transcriptional regulator
HG420_RS03230	COG4221	oxidoreductase activity
HG420_RS03240	COG0582	viral genome integration into host DNA
HG420_RS03310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG420_RS03315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG420_RS03320	COG2217	Heavy metal translocating P-type atpase
HG420_RS03330	COG1475	DNA binding
HG420_RS03335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG420_RS03340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG420_RS03355	COG0488	(ABC) transporter
HG420_RS03380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG420_RS03385	COG0726	polysaccharide deacetylase
HG420_RS03410	COG1011	Hydrolase
HG420_RS03415	COG0531	amino acid
HG420_RS03420	COG0204	Acyl-transferase
HG420_RS03430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HG420_RS03435	COG0653	protein targeting
HG420_RS03440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG420_RS03460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG420_RS03490	COG2076	Multidrug Resistance protein
HG420_RS03495	COG2814	Major facilitator Superfamily
HG420_RS03550	COG0594	ribonuclease P activity
HG420_RS03555	COG0706	membrane insertase activity
HG420_RS03565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HG420_RS03570	COG4989	oxidoreductase activity
HG420_RS03580	COG1266	CAAX protease self-immunity
HG420_RS03585	COG4472	Bacterial protein of unknown function (DUF965)
HG420_RS03595	COG3906	Belongs to the UPF0473 family
HG420_RS03605	COG0300	oxidoreductase activity
HG420_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
HG420_RS03620	COG1309	transcriptional regulator
HG420_RS03625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG420_RS03700	COG2814	Major facilitator Superfamily
HG420_RS03705	COG1832	CoA-binding protein
HG420_RS03730	COG0436	Aminotransferase
HG420_RS03735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HG420_RS03745	COG0154	amidase activity
HG420_RS03770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG420_RS03785	COG0346	lactoylglutathione lyase activity
HG420_RS03800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG420_RS03815	COG2723	6-phospho-beta-galactosidase activity
HG420_RS03820	COG0756	dUTP diphosphatase activity
HG420_RS03825	COG0737	Belongs to the 5'-nucleotidase family
HG420_RS03830	COG4470	Protein conserved in bacteria
HG420_RS03835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG420_RS03845	COG0142	geranyltranstransferase activity
HG420_RS03875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG420_RS03880	COG1461	Dihydroxyacetone kinase
HG420_RS03890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG420_RS03900	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HG420_RS03920	COG1088	dTDP-glucose 4,6-dehydratase activity
HG420_RS03940	COG0463	Glycosyl transferase, family 2
HG420_RS03960	COG1442	glycosyl transferase family 8
HG420_RS03960	COG1216	Glycosyl transferase, family 2
HG420_RS03995	COG1442	glycosyl transferase family 8
HG420_RS03995	COG1216	Glycosyl transferase, family 2
HG420_RS04000	COG1442	glycosyl transferase family 8
HG420_RS04000	COG1216	Glycosyl transferase, family 2
HG420_RS04005	COG1442	glycosyl transferase family 8
HG420_RS04005	COG1216	Glycosyl transferase, family 2
HG420_RS04010	COG3475	LICD family
HG420_RS04025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG420_RS04045	COG0516	GMP reductase activity
HG420_RS04045	COG0517	IMP dehydrogenase activity
HG420_RS04050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG420_RS04060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG420_RS04065	COG1534	Rna-binding protein
HG420_RS04075	COG1713	HD superfamily hydrolase involved in NAD metabolism
HG420_RS04085	COG0799	negative regulation of ribosome biogenesis
HG420_RS04090	COG2226	methyltransferase
HG420_RS04095	COG1323	Belongs to the UPF0348 family
HG420_RS04105	COG0217	transcriptional regulatory protein
HG420_RS04115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG420_RS04125	COG1309	transcriptional regulator
HG420_RS04135	COG0789	Transcriptional regulator
HG420_RS04140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG420_RS04155	COG0561	phosphatase activity
HG420_RS04165	COG2376	Dihydroxyacetone kinase
HG420_RS04170	COG1309	transcriptional regulator
HG420_RS04175	COG2376	Dihydroxyacetone kinase
HG420_RS04180	COG1461	Dihydroxyacetone kinase
HG420_RS04185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HG420_RS04190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG420_RS04195	COG4690	dipeptidase activity
HG420_RS04210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG420_RS04225	COG2081	HI0933 family
HG420_RS04230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG420_RS04245	COG1132	(ABC) transporter
HG420_RS04255	COG0673	inositol 2-dehydrogenase activity
HG420_RS04265	COG1854	S-ribosylhomocysteine lyase activity
HG420_RS04275	COG0656	L-ascorbic acid biosynthetic process
HG420_RS04280	COG1335	isochorismatase
HG420_RS04300	COG1328	CTP reductase activity
HG420_RS04335	COG1122	ATPase activity
HG420_RS04345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HG420_RS04380	COG0726	polysaccharide deacetylase
HG420_RS04400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG420_RS04405	COG2183	response to ionizing radiation
HG420_RS04410	COG3091	SprT-like family
HG420_RS04415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HG420_RS04435	COG5503	Protein of unknown function (DUF1447)
HG420_RS04450	COG0456	acetyltransferase
HG420_RS04490	COG3639	organic phosphonate transmembrane transporter activity
HG420_RS04495	COG0737	Belongs to the 5'-nucleotidase family
HG420_RS04515	COG1846	Transcriptional regulator
HG420_RS04520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HG420_RS04530	COG1132	(ABC) transporter
HG420_RS04535	COG1132	(ABC) transporter
HG420_RS04540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HG420_RS04545	COG4443	Transcriptional Coactivator p15 (PC4)
HG420_RS04565	COG1268	BioY protein
HG420_RS04570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HG420_RS04580	COG3859	Proton-coupled thiamine transporter YuaJ
HG420_RS04585	COG1464	Belongs to the NlpA lipoprotein family
HG420_RS04605	COG1464	Belongs to the NlpA lipoprotein family
HG420_RS04615	COG2011	ABC-type metal ion transport system permease component
HG420_RS04640	COG1120	ATPase activity
HG420_RS04645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG420_RS04650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG420_RS04655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HG420_RS04670	COG2814	Major facilitator Superfamily
HG420_RS04675	COG0656	L-ascorbic acid biosynthetic process
HG420_RS04680	COG1733	regulation of RNA biosynthetic process
HG420_RS04685	COG0346	lactoylglutathione lyase activity
HG420_RS04690	COG0588	phosphoglycerate mutase activity
HG420_RS04695	COG0450	alkyl hydroperoxide reductase
HG420_RS04700	COG3634	alkyl hydroperoxide reductase activity
HG420_RS04710	COG0768	penicillin binding
HG420_RS04715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HG420_RS04725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG420_RS04730	COG4166	transmembrane transport
HG420_RS04735	COG4166	transmembrane transport
HG420_RS04740	COG0601	transmembrane transport
HG420_RS04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG420_RS04750	COG0444	Belongs to the ABC transporter superfamily
HG420_RS04755	COG4608	Belongs to the ABC transporter superfamily
HG420_RS04765	COG0513	Belongs to the DEAD box helicase family
HG420_RS04775	COG0367	asparagine synthase
HG420_RS04785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG420_RS04790	COG1113	amino acid transport
HG420_RS04795	COG1113	amino acid transport
HG420_RS04825	COG2357	RelA SpoT domain protein
HG420_RS04835	COG0564	pseudouridine synthase activity
HG420_RS04845	COG0833	amino acid
HG420_RS04875	COG2855	membrane
HG420_RS04885	COG0583	DNA-binding transcription factor activity
HG420_RS04900	COG0301	tRNA thio-modification
HG420_RS04920	COG1764	response to oxidative stress
HG420_RS04925	COG0025	NhaP-type Na H and K H
HG420_RS04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG420_RS04945	COG1363	Peptidase, m42
HG420_RS04955	COG3118	belongs to the thioredoxin family
HG420_RS04960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG420_RS04965	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG420_RS04985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HG420_RS04990	COG5002	protein histidine kinase activity
HG420_RS04995	COG0745	RESPONSE REGULATOR receiver
HG420_RS05005	COG0470	DNA polymerase III
HG420_RS05010	COG1774	PSP1 C-terminal conserved region
HG420_RS05040	COG1846	Transcriptional regulator
HG420_RS05045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HG420_RS05060	COG1304	FMN binding
HG420_RS05065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG420_RS05075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HG420_RS05090	COG0513	Belongs to the DEAD box helicase family
HG420_RS05105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG420_RS05110	COG1447	Phosphotransferase system cellobiose-specific component IIA
HG420_RS05120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG420_RS05125	COG2723	6-phospho-beta-galactosidase activity
HG420_RS05145	COG1597	lipid kinase activity
HG420_RS05150	COG3842	ATPase activity
HG420_RS05185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG420_RS05185	COG1263	PTS System
HG420_RS05185	COG2190	(PTS) system
HG420_RS05190	COG1263	PTS System
HG420_RS05190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG420_RS05195	COG1554	hydrolase, family 65, central catalytic
HG420_RS05200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG420_RS05215	COG0802	atpase or kinase
HG420_RS05225	COG0582	viral genome integration into host DNA
HG420_RS05325	COG0351	phosphomethylpyrimidine kinase
HG420_RS05330	COG4720	Psort location CytoplasmicMembrane, score
HG420_RS05345	COG0504	CTP synthase activity
HG420_RS05425	COG1611	Belongs to the LOG family
HG420_RS05430	COG1428	Deoxynucleoside kinase
HG420_RS05445	COG0587	DNA-directed DNA polymerase activity
HG420_RS05450	COG1272	protein, Hemolysin III
HG420_RS05455	COG1307	EDD domain protein, DegV family
HG420_RS05460	COG2755	lipolytic protein G-D-S-L family
HG420_RS05465	COG1472	Belongs to the glycosyl hydrolase 3 family
HG420_RS05475	COG0776	regulation of translation
HG420_RS05480	COG0456	acetyltransferase
HG420_RS05485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG420_RS05490	COG2169	Transcriptional regulator
HG420_RS05535	COG1104	cysteine desulfurase activity
HG420_RS05540	COG0791	NLP P60 protein
HG420_RS05540	COG3883	PFAM NLP P60 protein
HG420_RS05545	COG4166	transmembrane transport
HG420_RS05555	COG1388	LysM domain
HG420_RS05555	COG1705	Flagellar rod assembly protein muramidase FlgJ
HG420_RS05575	COG4474	Belongs to the UPF0398 family
HG420_RS05580	COG1393	Belongs to the ArsC family
HG420_RS05585	COG4476	Belongs to the UPF0223 family
HG420_RS05590	COG0483	inositol monophosphate 1-phosphatase activity
HG420_RS05595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HG420_RS05705	COG0358	DNA primase activity
HG420_RS05710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG420_RS05740	COG0542	response to heat
HG420_RS05745	COG1959	2 iron, 2 sulfur cluster binding
HG420_RS05755	COG0242	peptide deformylase activity
HG420_RS05760	COG0494	nUDIX hydrolase
HG420_RS05790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG420_RS05795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG420_RS05800	COG0706	membrane insertase activity
HG420_RS05810	COG4684	Psort location CytoplasmicMembrane, score
HG420_RS05815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG420_RS05825	COG1942	4-Oxalocrotonate Tautomerase
HG420_RS05885	COG1435	thymidine kinase activity
HG420_RS05905	COG0778	Nitroreductase
HG420_RS05910	COG2890	protein-(glutamine-N5) methyltransferase activity
HG420_RS05920	COG0009	L-threonylcarbamoyladenylate synthase
HG420_RS05930	COG0741	lytic transglycosylase activity
HG420_RS05940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG420_RS05945	COG0560	Phosphoserine phosphatase
HG420_RS05955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG420_RS05970	COG0789	Transcriptional regulator
HG420_RS05980	COG0716	FMN binding
HG420_RS05995	COG0024	Methionine aminopeptidase
HG420_RS06005	COG2246	polysaccharide biosynthetic process
HG420_RS06030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HG420_RS06035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG420_RS06045	COG4980	gas vesicle protein
HG420_RS06050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG420_RS06115	COG0300	oxidoreductase activity
HG420_RS06120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG420_RS06120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG420_RS06125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG420_RS06135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HG420_RS06140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG420_RS06160	COG0542	response to heat
HG420_RS06165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HG420_RS06170	COG0148	phosphopyruvate hydratase activity
HG420_RS06180	COG0577	efflux transmembrane transporter activity
HG420_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
HG420_RS06200	COG1882	Formate acetyltransferase
HG420_RS06205	COG0237	dephospho-CoA kinase activity
HG420_RS06210	COG2814	Major facilitator Superfamily
HG420_RS06215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG420_RS06220	COG0772	Belongs to the SEDS family
HG420_RS06225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG420_RS06235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG420_RS06245	COG0740	serine-type endopeptidase activity
HG420_RS06255	COG1393	Belongs to the ArsC family
HG420_RS06285	COG0726	polysaccharide deacetylase
HG420_RS06290	COG1114	Component of the transport system for branched-chain amino acids
HG420_RS06300	COG3592	Divergent 4Fe-4S mono-cluster
HG420_RS06305	COG0084	hydrolase, TatD family'
HG420_RS06315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HG420_RS06320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG420_RS06325	COG0006	proline dipeptidase activity
HG420_RS06330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG420_RS06340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG420_RS06355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG420_RS06360	COG0297	glycogen (starch) synthase activity
HG420_RS06385	COG1266	CAAX protease self-immunity
HG420_RS06390	COG3104	oligopeptide transport
HG420_RS06395	COG1271	oxidase subunit
HG420_RS06400	COG1294	oxidase, subunit
HG420_RS06405	COG4988	ABC transporter
HG420_RS06410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HG420_RS06415	COG1846	Transcriptional regulator
HG420_RS06440	COG0586	Pfam SNARE associated Golgi protein
HG420_RS06465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG420_RS06490	COG1234	tRNA 3'-trailer cleavage
HG420_RS06520	COG0395	ABC-type sugar transport system, permease component
HG420_RS06525	COG1653	transport
HG420_RS06540	COG1609	Transcriptional regulator
HG420_RS06550	COG4948	Mandelate Racemase Muconate Lactonizing
HG420_RS06555	COG0318	PFAM AMP-dependent synthetase and ligase
HG420_RS06560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HG420_RS06565	COG2267	carboxylic ester hydrolase activity
HG420_RS06575	COG1169	isochorismate synthase
HG420_RS06585	COG4109	DRTGG domain
HG420_RS06590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG420_RS06600	COG0252	asparaginase activity
HG420_RS06615	COG2268	Band 7 protein
HG420_RS06620	COG0527	aspartate kinase activity
HG420_RS06635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG420_RS06650	COG0305	Participates in initiation and elongation during chromosome replication
HG420_RS06670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG420_RS06680	COG1484	DNA-dependent DNA replication
HG420_RS06685	COG0778	Nitroreductase
HG420_RS06695	COG1160	GTP binding
HG420_RS06745	COG1346	cytolysis
HG420_RS06760	COG0195	Participates in both transcription termination and antitermination
HG420_RS06765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HG420_RS06780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG420_RS06785	COG1482	cell wall glycoprotein biosynthetic process
HG420_RS06800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG420_RS06805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG420_RS06810	COG1028	Short-chain dehydrogenase reductase Sdr
HG420_RS06815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG420_RS06830	COG0439	Biotin carboxylase
HG420_RS06860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG420_RS06865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG420_RS06870	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG420_RS06875	COG1937	Protein conserved in bacteria
HG420_RS06880	COG1393	Belongs to the ArsC family
HG420_RS06885	COG1349	DNA-binding transcription factor activity
HG420_RS06895	COG0708	Exodeoxyribonuclease III
HG420_RS06900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG420_RS06900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG420_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
HG420_RS06915	COG4708	membrane
HG420_RS06940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HG420_RS06945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG420_RS06950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG420_RS06960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG420_RS06975	COG1196	nuclear chromosome segregation
HG420_RS06980	COG1368	sulfuric ester hydrolase activity
HG420_RS07005	COG0561	phosphatase activity
HG420_RS07015	COG0552	protein localization to endoplasmic reticulum
HG420_RS07020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG420_RS07040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG420_RS07045	COG2723	6-phospho-beta-galactosidase activity
HG420_RS07065	COG1252	NADH dehydrogenase
HG420_RS07070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG420_RS07075	COG1760	l-serine dehydratase
HG420_RS07080	COG1760	l-serine dehydratase
HG420_RS07085	COG3682	Transcriptional regulator
HG420_RS07090	COG2608	mercury ion transmembrane transporter activity
HG420_RS07095	COG2217	Heavy metal translocating P-type atpase
HG420_RS07120	COG0539	negative regulation of cytoplasmic translation
HG420_RS07130	COG0745	RESPONSE REGULATOR receiver
HG420_RS07135	COG5002	protein histidine kinase activity
HG420_RS07145	COG3201	nicotinamide mononucleotide transporter
HG420_RS07150	COG0322	excinuclease ABC activity
HG420_RS07155	COG1194	a g-specific adenine glycosylase
HG420_RS07165	COG0653	protein targeting
HG420_RS07205	COG0736	holo-[acyl-carrier-protein] synthase activity
HG420_RS07220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG420_RS07230	COG1174	glycine betaine transport
HG420_RS07265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG420_RS07270	COG1570	exodeoxyribonuclease VII activity
HG420_RS07285	COG1929	Belongs to the glycerate kinase type-1 family
HG420_RS07300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HG420_RS07305	COG1438	arginine binding
HG420_RS07310	COG0497	DNA recombination
HG420_RS07330	COG0275	rRNA processing
HG420_RS07340	COG0768	penicillin binding
HG420_RS07345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG420_RS07360	COG1136	(ABC) transporter
HG420_RS07365	COG0583	DNA-binding transcription factor activity
HG420_RS07375	COG2357	RelA SpoT domain protein
HG420_RS07380	COG0335	large ribosomal subunit rRNA binding
HG420_RS07405	COG1215	transferase activity, transferring glycosyl groups
HG420_RS07430	COG0589	response to stress
HG420_RS07460	COG2151	metal-sulfur cluster biosynthetic enzyme
HG420_RS07465	COG4974	Belongs to the 'phage' integrase family
HG420_RS07495	COG4585	Histidine kinase
HG420_RS07500	COG2197	response regulator
HG420_RS07515	COG0539	negative regulation of cytoplasmic translation
HG420_RS07525	COG0772	Belongs to the SEDS family
HG420_RS07545	COG0488	(ABC) transporter
HG420_RS07550	COG0281	malic enzyme
HG420_RS07585	COG0187	DNA topoisomerase II activity
HG420_RS07630	COG1442	glycosyl transferase family 8
HG420_RS07650	COG1316	TRANSCRIPTIONal
HG420_RS07665	COG0813	purine-nucleoside phosphorylase activity
HG420_RS07680	COG0393	Putative heavy-metal-binding
HG420_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG420_RS07705	COG0765	amino acid transport
HG420_RS07710	COG1126	abc transporter atp-binding protein
HG420_RS07720	COG0492	ferredoxin-NADP+ reductase activity
HG420_RS07730	COG0557	exoribonuclease II activity
HG420_RS07760	COG3830	Belongs to the UPF0237 family
HG420_RS07775	COG0588	phosphoglycerate mutase activity
HG420_RS07795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG420_RS07805	COG5617	Psort location CytoplasmicMembrane, score
HG420_RS07815	COG1473	amidohydrolase
HG420_RS07820	COG1349	DNA-binding transcription factor activity
HG420_RS07825	COG1105	Belongs to the carbohydrate kinase PfkB family
HG420_RS07830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG420_RS07830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG420_RS07830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG420_RS07870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG420_RS07875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG420_RS07885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HG420_RS07890	COG1481	regulation of sporulation
HG420_RS07900	COG1131	(ABC) transporter
HG420_RS07935	COG2884	Cell division ATP-binding protein ftsE
HG420_RS07940	COG2177	Part of the ABC transporter FtsEX involved in
HG420_RS07945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG420_RS07950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG420_RS07960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG420_RS07970	COG0187	DNA topoisomerase II activity
HG420_RS07980	COG2176	DNA-directed DNA polymerase activity
HG420_RS08020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG420_RS08020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG420_RS08025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG420_RS08050	COG0564	pseudouridine synthase activity
HG420_RS08065	COG0463	Glycosyl transferase, family 2
HG420_RS08070	COG0745	RESPONSE REGULATOR receiver
HG420_RS08085	COG0671	phosphoesterase, PA-phosphatase related
HG420_RS08090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG420_RS08100	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HG420_RS08105	COG1393	Belongs to the ArsC family
HG420_RS08110	COG0488	(ABC) transporter
HG420_RS08125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG420_RS08150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG420_RS08155	COG2384	SAM-dependent methyltransferase
HG420_RS08160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG420_RS08175	COG1078	dGTPase activity
HG420_RS08190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG420_RS08200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG420_RS08210	COG1702	phosphate starvation-inducible protein PhoH
HG420_RS08220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG420_RS08225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG420_RS08245	COG1739	Uncharacterized protein family UPF0029
HG420_RS08260	COG0737	Belongs to the 5'-nucleotidase family
HG420_RS08285	COG0038	chloride channel
HG420_RS08290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG420_RS08295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG420_RS08310	COG1136	(ABC) transporter
HG420_RS08320	COG3442	glutamine amidotransferase
HG420_RS08325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG420_RS08330	COG3527	Alpha-acetolactate decarboxylase
HG420_RS08340	COG0702	epimerase
HG420_RS08375	COG3764	Sortase (surface protein transpeptidase)
HG420_RS08395	COG0210	DNA helicase
HG420_RS08405	COG0519	Catalyzes the synthesis of GMP from XMP
HG420_RS08415	COG1053	succinate dehydrogenase
HG420_RS08475	COG0196	riboflavin kinase activity
HG420_RS08480	COG0039	L-malate dehydrogenase activity
HG420_RS08490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HG420_RS08495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG420_RS08495	COG1263	PTS System
HG420_RS08500	COG1737	Transcriptional regulator
HG420_RS08530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG420_RS08550	COG0647	UMP catabolic process
HG420_RS08595	COG2233	PERMEase
HG420_RS08605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG420_RS08610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HG420_RS08635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG420_RS08635	COG0302	gtp cyclohydrolase
HG420_RS08640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG420_RS08650	COG0285	dihydrofolate synthase activity
HG420_RS08655	COG1428	Deoxynucleoside kinase
HG420_RS08685	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG420_RS08690	COG1177	transmembrane transport
HG420_RS08715	COG3507	Belongs to the glycosyl hydrolase 43 family
HG420_RS08740	COG1393	Belongs to the ArsC family
HG420_RS08750	COG0656	L-ascorbic acid biosynthetic process
HG420_RS08775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG420_RS08780	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HG420_RS08785	COG2226	methyltransferase
HG420_RS08790	COG0628	permease
HG420_RS08800	COG0028	Belongs to the TPP enzyme family
HG420_RS08805	COG2814	Major facilitator Superfamily
HG420_RS08810	COG1733	regulation of RNA biosynthetic process
HG420_RS08825	COG0557	exoribonuclease II activity
HG420_RS08865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG420_RS08875	COG3231	kanamycin kinase activity
HG420_RS08880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG420_RS08895	COG0140	phosphoribosyl-ATP diphosphatase activity
HG420_RS08895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG420_RS08900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HG420_RS08905	COG1054	Belongs to the UPF0176 family
HG420_RS08935	COG0473	3-isopropylmalate dehydrogenase activity
HG420_RS08960	COG0066	3-isopropylmalate dehydratase activity
HG420_RS08965	COG1119	ATPase activity
HG420_RS08980	COG0440	acetolactate synthase activity
HG420_RS08990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HG420_RS08995	COG3527	Alpha-acetolactate decarboxylase
HG420_RS09000	COG0251	oxidation-reduction process
HG420_RS09005	COG0758	DNA mediated transformation
HG420_RS09010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG420_RS09075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG420_RS09080	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HG420_RS09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG420_RS09090	COG1696	Membrane protein involved in D-alanine export
HG420_RS09095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG420_RS09110	COG0351	phosphomethylpyrimidine kinase
HG420_RS09140	COG2814	Major facilitator Superfamily
HG420_RS09155	COG0222	ribosome binding
HG420_RS09160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG420_RS09175	COG3620	sequence-specific DNA binding
HG420_RS09180	COG1132	(ABC) transporter
HG420_RS09185	COG1132	(ABC) transporter
HG420_RS09210	COG1187	pseudouridine synthase activity
HG420_RS09215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG420_RS09225	COG4974	Belongs to the 'phage' integrase family
HG420_RS09240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG420_RS09250	COG3763	UPF0154 protein
HG420_RS09260	COG0493	'glutamate synthase
HG420_RS09265	COG0070	glutamate synthase
HG420_RS09265	COG0067	glutamate synthase
HG420_RS09265	COG0069	glutamate synthase activity
HG420_RS09270	COG0110	maltose O-acetyltransferase activity
HG420_RS09275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG420_RS09280	COG0668	transmembrane transport
HG420_RS09290	COG0531	amino acid
HG420_RS09340	COG1349	DNA-binding transcription factor activity
HG420_RS09365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HG420_RS09370	COG0395	ABC-type sugar transport system, permease component
HG420_RS09395	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG420_RS09420	COG0419	ATPase involved in DNA repair
HG420_RS09425	COG0420	3'-5' exonuclease activity
HG420_RS09430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG420_RS09435	COG1393	Belongs to the ArsC family
HG420_RS09455	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HG420_RS09460	COG2226	methyltransferase
HG420_RS09465	COG3845	ABC transporter
HG420_RS09470	COG4603	Belongs to the binding-protein-dependent transport system permease family
HG420_RS09475	COG1079	Belongs to the binding-protein-dependent transport system permease family
HG420_RS09480	COG0039	L-malate dehydrogenase activity
HG420_RS09485	COG0469	pyruvate kinase activity
HG420_RS09490	COG0205	6-phosphofructokinase activity
HG420_RS09500	COG3853	Toxic anion resistance protein (TelA)
HG420_RS09510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG420_RS09530	COG0142	geranyltranstransferase activity
HG420_RS09550	COG0167	dihydroorotate dehydrogenase activity
HG420_RS09560	COG2814	Major facilitator Superfamily
HG420_RS09565	COG2188	Transcriptional regulator
HG420_RS09570	COG2723	6-phospho-beta-galactosidase activity
HG420_RS09590	COG1175	transmembrane transport
HG420_RS09625	COG1187	pseudouridine synthase activity
HG420_RS09630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG420_RS09635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG420_RS09685	COG0386	Belongs to the glutathione peroxidase family
HG420_RS09695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG420_RS09735	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HG420_RS09740	COG0745	RESPONSE REGULATOR receiver
HG420_RS09755	COG2188	Transcriptional regulator
HG420_RS09760	COG1744	ABC transporter substrate-binding protein PnrA-like
HG420_RS09770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HG420_RS09785	COG2813	Specifically methylates the guanine in position
HG420_RS09790	COG1072	(Pantothenic acid kinase))
HG420_RS09795	COG3223	Belongs to the PsiE family
HG420_RS09810	COG1475	DNA binding
HG420_RS09815	COG3969	phosphoadenosine phosphosulfate
HG420_RS09835	COG3448	diguanylate cyclase activity
HG420_RS09835	COG4175	Glycine betaine
HG420_RS09845	COG2723	6-phospho-beta-galactosidase activity
HG420_RS09875	COG0135	phosphoribosylanthranilate isomerase activity
HG420_RS09880	COG0134	indole-3-glycerol-phosphate synthase activity
HG420_RS09900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG420_RS09905	COG0512	Glutamine amidotransferase of anthranilate synthase
HG420_RS09910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG420_RS09915	COG3759	membrane
HG420_RS09920	COG0778	Nitroreductase
HG420_RS09945	COG0735	belongs to the Fur family
HG420_RS09960	COG4221	oxidoreductase activity
HG420_RS09965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG420_RS09970	COG1846	Transcriptional regulator
HG420_RS09995	COG1653	transport
HG420_RS10000	COG0395	ABC-type sugar transport system, permease component
HG420_RS10005	COG4209	transmembrane transport
HG420_RS10010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG420_RS10010	COG0519	Catalyzes the synthesis of GMP from XMP
HG420_RS10030	COG2115	Belongs to the xylose isomerase family
HG420_RS10045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG420_RS10050	COG0561	phosphatase activity
HG420_RS10055	COG0151	Belongs to the GarS family
HG420_RS10075	COG0138	bifunctional purine biosynthesis protein purh
HG420_RS10100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG420_RS10105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG420_RS10110	COG0542	response to heat
HG420_RS10150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG420_RS10180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HG420_RS10190	COG4221	oxidoreductase activity
HG420_RS10195	COG0477	Major facilitator Superfamily
HG420_RS10200	COG1846	Transcriptional regulator
HG420_RS10230	COG2723	6-phospho-beta-galactosidase activity
HG420_RS10235	COG0698	ribose 5-phosphate isomerase
HG420_RS10240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG420_RS10245	COG1609	Transcriptional regulator
HG420_RS10250	COG1063	alcohol dehydrogenase
HG420_RS10265	COG0167	dihydroorotate dehydrogenase activity
HG420_RS10270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG420_RS10275	COG0673	inositol 2-dehydrogenase activity
HG420_RS10285	COG0488	(ABC) transporter
HG420_RS10295	COG0371	Dehydrogenase
HG420_RS10305	COG4690	dipeptidase activity
HG420_RS10310	COG0617	tRNA 3'-terminal CCA addition
HG420_RS10320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG420_RS10325	COG1307	EDD domain protein, DegV family
HG420_RS10335	COG0336	Belongs to the RNA methyltransferase TrmD family
HG420_RS10355	COG1837	Belongs to the UPF0109 family
HG420_RS10360	COG0228	four-way junction DNA binding
HG420_RS10370	COG0183	Belongs to the thiolase family
HG420_RS10375	COG3425	synthase
HG420_RS10380	COG0363	glucosamine-6-phosphate deaminase activity
HG420_RS10390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG420_RS10405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG420_RS10415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG420_RS10420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG420_RS10425	COG0347	Belongs to the P(II) protein family
HG420_RS10430	COG0004	ammonium transporteR
HG420_RS10435	COG5002	protein histidine kinase activity
HG420_RS10440	COG0745	RESPONSE REGULATOR receiver
HG420_RS10450	COG0254	rRNA binding
HG420_RS10470	COG0505	Belongs to the CarA family
HG420_RS10505	COG1230	cation diffusion facilitator family transporter
HG420_RS10550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG420_RS10555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG420_RS10575	COG1285	pathogenesis
HG420_RS10590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG420_RS10625	COG0800	Aldolase
HG420_RS10650	COG1312	Catalyzes the dehydration of D-mannonate
HG420_RS10660	COG1802	Transcriptional regulator
HG420_RS10665	COG0477	Major facilitator Superfamily
HG420_RS10705	COG1869	D-ribose catabolic process
HG420_RS10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG420_RS10715	COG1609	Transcriptional regulator
HG420_RS10720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG420_RS10740	COG3118	belongs to the thioredoxin family
HG420_RS10750	COG1286	toxin biosynthetic process
HG420_RS10760	COG1609	Transcriptional regulator
HG420_RS10765	COG0006	proline dipeptidase activity
HG420_RS10775	COG0116	Belongs to the methyltransferase superfamily
HG420_RS10785	COG3599	regulation of cell shape
HG420_RS10790	COG1466	dna polymerase III delta subunit
HG420_RS10800	COG1674	ftsk spoiiie
HG420_RS10805	COG0561	phosphatase activity
HG420_RS10815	COG0280	phosphate acetyltransferase
HG420_RS10820	COG0572	uridine kinase
HG420_RS10830	COG0673	inositol 2-dehydrogenase activity
HG420_RS10840	COG0741	lytic transglycosylase activity
HG420_RS10885	COG2723	6-phospho-beta-galactosidase activity
HG420_RS10895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG420_RS10900	COG5002	protein histidine kinase activity
HG420_RS10905	COG0745	RESPONSE REGULATOR receiver
HG420_RS10910	COG1609	Transcriptional regulator
HG420_RS10930	COG0110	maltose O-acetyltransferase activity
HG420_RS10935	COG0366	Alpha amylase catalytic
HG420_RS10940	COG0366	Alpha amylase catalytic
HG420_RS10955	COG3833	ABC-type maltose transport systems, permease component
HG420_RS11005	COG3715	PTS system
HG420_RS11010	COG3716	PTS system mannose fructose sorbose family IID component
HG420_RS11030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG420_RS11050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HG420_RS11060	COG0704	Plays a role in the regulation of phosphate uptake
HG420_RS11065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG420_RS11070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG420_RS11075	COG0581	inorganic phosphate transmembrane transporter activity
HG420_RS11080	COG0573	inorganic phosphate transmembrane transporter activity
HG420_RS11095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG420_RS11120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG420_RS11125	COG4122	O-methyltransferase activity
HG420_RS11150	COG2252	PERMEase
HG420_RS11155	COG0561	phosphatase activity
HG420_RS11160	COG0247	lactate metabolic process
HG420_RS11170	COG1556	Lactate utilization protein
HG420_RS11175	COG0670	Belongs to the BI1 family
HG420_RS11190	COG0268	Binds directly to 16S ribosomal RNA
HG420_RS11220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG420_RS11230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG420_RS11245	COG3708	Transcriptional regulator
HG420_RS11245	COG2207	Transcriptional regulator
HG420_RS11255	COG3527	Alpha-acetolactate decarboxylase
HG420_RS11275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG420_RS11295	COG0601	transmembrane transport
HG420_RS11300	COG4608	Belongs to the ABC transporter superfamily
HG420_RS11360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG420_RS11445	COG2746	aminoglycoside 3-N-acetyltransferase activity
HG420_RS11470	COG1914	H( )-stimulated, divalent metal cation uptake system
HG420_RS11500	COG0277	FAD linked oxidase domain protein
HG420_RS11530	COG3979	chitinase
HG420_RS11540	COG2223	nitrite transmembrane transporter activity
HG420_RS11565	COG3843	relaxase mobilization nuclease domain protein
HG420_RS11600	COG1473	amidohydrolase
HG420_RS11610	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HG420_RS11680	COG1266	CAAX protease self-immunity
HG420_RS11805	COG1192	Involved in chromosome partitioning
HG420_RS11820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG420_RS11860	COG1278	Cold shock
HG420_RS11925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG420_RS12005	COG3708	Transcriptional regulator
HG420_RS12005	COG2207	Transcriptional regulator
HG420_RS12035	COG1192	Involved in chromosome partitioning
HG420_RS12050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII