locus-tag	class	description
I6H59_RS00150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H59_RS00205	COG1316	TRANSCRIPTIONal
I6H59_RS00230	COG0438	transferase activity, transferring glycosyl groups
I6H59_RS00280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H59_RS00300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H59_RS00305	COG4464	protein tyrosine phosphatase activity
I6H59_RS00310	COG0489	protein tyrosine kinase activity
I6H59_RS00390	COG1164	Oligoendopeptidase f
I6H59_RS00410	COG1393	Belongs to the ArsC family
I6H59_RS00420	COG3177	Filamentation induced by cAMP protein fic
I6H59_RS00425	COG3843	relaxase mobilization nuclease domain protein
I6H59_RS00560	COG3620	sequence-specific DNA binding
I6H59_RS00590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H59_RS00595	COG2814	Major facilitator Superfamily
I6H59_RS00615	COG0647	UMP catabolic process
I6H59_RS00635	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H59_RS00655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS00665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS00680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H59_RS00690	COG0488	(ABC) transporter
I6H59_RS00695	COG0517	IMP dehydrogenase activity
I6H59_RS00695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H59_RS00705	COG1187	pseudouridine synthase activity
I6H59_RS00720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H59_RS00725	COG0741	lytic transglycosylase activity
I6H59_RS00795	COG0582	viral genome integration into host DNA
I6H59_RS00805	COG1177	transmembrane transport
I6H59_RS00810	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H59_RS00815	COG3842	ATPase activity
I6H59_RS00825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H59_RS00830	COG0564	pseudouridine synthase activity
I6H59_RS00850	COG1393	Belongs to the ArsC family
I6H59_RS00855	COG1408	metallophosphoesterase
I6H59_RS00865	COG1470	cell adhesion involved in biofilm formation
I6H59_RS00870	COG0246	Mannitol dehydrogenase
I6H59_RS00875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS00885	COG2213	PTS system mannitol-specific
I6H59_RS00895	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H59_RS00910	COG1764	response to oxidative stress
I6H59_RS00925	COG3759	membrane
I6H59_RS00935	COG0577	efflux transmembrane transporter activity
I6H59_RS00940	COG1136	(ABC) transporter
I6H59_RS00950	COG1396	sequence-specific DNA binding
I6H59_RS00995	COG3527	Alpha-acetolactate decarboxylase
I6H59_RS01005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H59_RS01010	COG3442	glutamine amidotransferase
I6H59_RS01020	COG1136	(ABC) transporter
I6H59_RS01020	COG0577	efflux transmembrane transporter activity
I6H59_RS01025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H59_RS01035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H59_RS01040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H59_RS01045	COG0557	exoribonuclease II activity
I6H59_RS01050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H59_RS01055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H59_RS01065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H59_RS01070	COG0419	ATPase involved in DNA repair
I6H59_RS01075	COG0420	3'-5' exonuclease activity
I6H59_RS01090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H59_RS01100	COG1940	carbohydrate kinase activity
I6H59_RS01115	COG0383	alpha-mannosidase activity
I6H59_RS01120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS01120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS01125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS01125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS01130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H59_RS01135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H59_RS01140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H59_RS01165	COG0038	chloride channel
I6H59_RS01170	COG4224	UPF0291 protein
I6H59_RS01175	COG0751	glycine-tRNA ligase activity
I6H59_RS01185	COG2116	formate transmembrane transporter activity
I6H59_RS01200	COG1739	Uncharacterized protein family UPF0029
I6H59_RS01205	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H59_RS01210	COG1040	competence protein
I6H59_RS01215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H59_RS01220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H59_RS01230	COG1702	phosphate starvation-inducible protein PhoH
I6H59_RS01245	COG1131	(ABC) transporter
I6H59_RS01250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H59_RS01260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H59_RS01280	COG1078	dGTPase activity
I6H59_RS01295	COG1054	Belongs to the UPF0176 family
I6H59_RS01330	COG1131	(ABC) transporter
I6H59_RS01340	COG1481	regulation of sporulation
I6H59_RS01345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H59_RS01360	COG0488	(ABC) transporter
I6H59_RS01370	COG1113	amino acid transport
I6H59_RS01375	COG0561	phosphatase activity
I6H59_RS01380	COG1609	Transcriptional regulator
I6H59_RS01390	COG1461	Dihydroxyacetone kinase
I6H59_RS01420	COG2261	transglycosylase associated protein
I6H59_RS01445	COG0557	exoribonuclease II activity
I6H59_RS01450	COG1051	belongs to the nudix hydrolase family
I6H59_RS01470	COG5002	protein histidine kinase activity
I6H59_RS01475	COG0745	RESPONSE REGULATOR receiver
I6H59_RS01480	COG0346	lactoylglutathione lyase activity
I6H59_RS01500	COG0492	ferredoxin-NADP+ reductase activity
I6H59_RS01510	COG1126	abc transporter atp-binding protein
I6H59_RS01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H59_RS01535	COG0813	purine-nucleoside phosphorylase activity
I6H59_RS01540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6H59_RS01575	COG2814	Major facilitator Superfamily
I6H59_RS01590	COG0187	DNA topoisomerase II activity
I6H59_RS01605	COG1834	amidinotransferase
I6H59_RS01615	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H59_RS01630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H59_RS01645	COG0149	triose-phosphate isomerase activity
I6H59_RS01650	COG0196	riboflavin kinase activity
I6H59_RS01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H59_RS01670	COG2818	Glycosylase
I6H59_RS01690	COG3764	Sortase (surface protein transpeptidase)
I6H59_RS01705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H59_RS01710	COG2153	protein acetylation
I6H59_RS01715	COG2176	DNA-directed DNA polymerase activity
I6H59_RS01720	COG0187	DNA topoisomerase II activity
I6H59_RS01725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H59_RS01730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H59_RS01735	COG1780	Probably involved in ribonucleotide reductase function
I6H59_RS01740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H59_RS01750	COG2177	Part of the ABC transporter FtsEX involved in
I6H59_RS01755	COG2884	Cell division ATP-binding protein ftsE
I6H59_RS01760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H59_RS01765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H59_RS01770	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H59_RS01775	COG3845	ABC transporter
I6H59_RS01780	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H59_RS01785	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H59_RS01800	COG0039	L-malate dehydrogenase activity
I6H59_RS01805	COG0469	pyruvate kinase activity
I6H59_RS01810	COG0205	6-phosphofructokinase activity
I6H59_RS01820	COG3853	Toxic anion resistance protein (TelA)
I6H59_RS01865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H59_RS01870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H59_RS01880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H59_RS01890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H59_RS01895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H59_RS01910	COG0142	geranyltranstransferase activity
I6H59_RS01915	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H59_RS01925	COG0167	dihydroorotate dehydrogenase activity
I6H59_RS01930	COG0543	2 iron, 2 sulfur cluster binding
I6H59_RS01940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H59_RS01950	COG1187	pseudouridine synthase activity
I6H59_RS01955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H59_RS01960	COG1393	Belongs to the ArsC family
I6H59_RS01965	COG1668	transmembrane transport
I6H59_RS01970	COG4152	abc transporter atp-binding protein
I6H59_RS01975	COG3942	CHAP domain
I6H59_RS01975	COG3883	PFAM NLP P60 protein
I6H59_RS01985	COG0772	Belongs to the SEDS family
I6H59_RS01995	COG1098	S1 RNA binding domain
I6H59_RS02010	COG2197	response regulator
I6H59_RS02015	COG4585	Histidine kinase
I6H59_RS02065	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H59_RS02075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6H59_RS02080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS02080	COG1263	PTS System
I6H59_RS02085	COG1737	Transcriptional regulator
I6H59_RS02085	COG0837	glucose binding
I6H59_RS02105	COG0463	Glycosyl transferase, family 2
I6H59_RS02340	COG1396	sequence-specific DNA binding
I6H59_RS02350	COG0582	viral genome integration into host DNA
I6H59_RS02355	COG0335	large ribosomal subunit rRNA binding
I6H59_RS02365	COG0745	RESPONSE REGULATOR receiver
I6H59_RS02370	COG2357	RelA SpoT domain protein
I6H59_RS02375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H59_RS02380	COG0768	penicillin binding
I6H59_RS02390	COG0275	rRNA processing
I6H59_RS02395	COG2348	transferase activity, transferring amino-acyl groups
I6H59_RS02410	COG3118	belongs to the thioredoxin family
I6H59_RS02425	COG0492	ferredoxin-NADP+ reductase activity
I6H59_RS02445	COG0497	DNA recombination
I6H59_RS02450	COG1438	arginine binding
I6H59_RS02455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H59_RS02475	COG1722	exodeoxyribonuclease VII activity
I6H59_RS02480	COG1570	exodeoxyribonuclease VII activity
I6H59_RS02485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H59_RS02495	COG2076	Multidrug Resistance protein
I6H59_RS02505	COG1393	Belongs to the ArsC family
I6H59_RS02515	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H59_RS02520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS02520	COG1263	PTS System
I6H59_RS02525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H59_RS02535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H59_RS02540	COG1194	a g-specific adenine glycosylase
I6H59_RS02550	COG0322	excinuclease ABC activity
I6H59_RS02555	COG3739	integral membrane protein
I6H59_RS02560	COG2217	Heavy metal translocating P-type atpase
I6H59_RS02570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H59_RS02575	COG0710	3-dehydroquinate dehydratase activity
I6H59_RS02590	COG1609	Transcriptional regulator
I6H59_RS02605	COG1070	Carbohydrate kinase
I6H59_RS02610	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS02615	COG1263	PTS System
I6H59_RS02615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS02620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H59_RS02625	COG1737	Transcriptional regulator
I6H59_RS02635	COG0116	Belongs to the methyltransferase superfamily
I6H59_RS02655	COG1674	ftsk spoiiie
I6H59_RS02670	COG0561	phosphatase activity
I6H59_RS02675	COG4708	membrane
I6H59_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
I6H59_RS02690	COG4221	oxidoreductase activity
I6H59_RS02695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H59_RS02695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H59_RS02700	COG0708	Exodeoxyribonuclease III
I6H59_RS02705	COG1393	Belongs to the ArsC family
I6H59_RS02720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H59_RS02725	COG0463	Glycosyl transferase, family 2
I6H59_RS02730	COG0439	Biotin carboxylase
I6H59_RS02745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H59_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
I6H59_RS02755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H59_RS02760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H59_RS02765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H59_RS02775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H59_RS02780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H59_RS02785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H59_RS02790	COG1120	ATPase activity
I6H59_RS02795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H59_RS02800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H59_RS02805	COG5002	protein histidine kinase activity
I6H59_RS02810	COG0745	RESPONSE REGULATOR receiver
I6H59_RS02815	COG1609	Transcriptional regulator
I6H59_RS02820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H59_RS02830	COG0366	Alpha amylase catalytic
I6H59_RS02845	COG1175	transmembrane transport
I6H59_RS02850	COG3833	ABC-type maltose transport systems, permease component
I6H59_RS02860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H59_RS02875	COG3153	acetyltransferase
I6H59_RS02880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H59_RS02900	COG3715	PTS system
I6H59_RS02905	COG3716	PTS system mannose fructose sorbose family IID component
I6H59_RS02920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H59_RS02925	COG0704	Plays a role in the regulation of phosphate uptake
I6H59_RS02930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H59_RS02935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H59_RS02940	COG0581	inorganic phosphate transmembrane transporter activity
I6H59_RS02945	COG0573	inorganic phosphate transmembrane transporter activity
I6H59_RS02960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H59_RS02965	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS02970	COG0588	phosphoglycerate mutase activity
I6H59_RS02975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H59_RS02985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H59_RS02990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H59_RS02995	COG4122	O-methyltransferase activity
I6H59_RS03000	COG1164	Oligoendopeptidase f
I6H59_RS03015	COG2252	PERMEase
I6H59_RS03020	COG0561	phosphatase activity
I6H59_RS03025	COG0670	Belongs to the BI1 family
I6H59_RS03040	COG0268	Binds directly to 16S ribosomal RNA
I6H59_RS03055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H59_RS03065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H59_RS03080	COG5002	protein histidine kinase activity
I6H59_RS03085	COG0745	RESPONSE REGULATOR receiver
I6H59_RS03095	COG0577	efflux transmembrane transporter activity
I6H59_RS03100	COG1136	(ABC) transporter
I6H59_RS03110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H59_RS03115	COG4493	Belongs to the UPF0637 family
I6H59_RS03125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H59_RS03140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H59_RS03145	COG1126	abc transporter atp-binding protein
I6H59_RS03155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H59_RS03165	COG1126	abc transporter atp-binding protein
I6H59_RS03170	COG0765	amino acid transport
I6H59_RS03175	COG5002	protein histidine kinase activity
I6H59_RS03180	COG0745	RESPONSE REGULATOR receiver
I6H59_RS03190	COG0254	rRNA binding
I6H59_RS03195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS03195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS03195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS03200	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H59_RS03205	COG1349	DNA-binding transcription factor activity
I6H59_RS03210	COG1393	Belongs to the ArsC family
I6H59_RS03215	COG0443	Heat shock 70 kDa protein
I6H59_RS03220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H59_RS03240	COG0406	alpha-ribazole phosphatase activity
I6H59_RS03265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H59_RS03270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H59_RS03275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H59_RS03280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H59_RS03285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H59_RS03290	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H59_RS03295	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H59_RS03305	COG2333	competence protein COMEC
I6H59_RS03305	COG0658	competence protein
I6H59_RS03310	COG1596	polysaccharide export
I6H59_RS03310	COG1555	photosystem II stabilization
I6H59_RS03320	COG0488	(ABC) transporter
I6H59_RS03330	COG0719	Fe-S assembly protein
I6H59_RS03340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H59_RS03345	COG0719	Fe-S assembly protein
I6H59_RS03355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H59_RS03360	COG4862	establishment of competence for transformation
I6H59_RS03370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H59_RS03375	COG0085	RNA polymerase activity
I6H59_RS03385	COG3590	peptidase
I6H59_RS03390	COG2244	polysaccharide biosynthetic process
I6H59_RS03405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H59_RS03425	COG1227	inorganic diphosphatase activity
I6H59_RS03430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H59_RS03435	COG2814	Major facilitator Superfamily
I6H59_RS03445	COG0628	permease
I6H59_RS03455	COG1573	uracil-dna glycosylase
I6H59_RS03460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H59_RS03485	COG0842	Transport permease protein
I6H59_RS03490	COG1131	(ABC) transporter
I6H59_RS03495	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H59_RS03500	COG0084	hydrolase, TatD family'
I6H59_RS03505	COG1393	Belongs to the ArsC family
I6H59_RS03515	COG0346	lactoylglutathione lyase activity
I6H59_RS03525	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6H59_RS03530	COG0772	Belongs to the SEDS family
I6H59_RS03535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H59_RS03540	COG2814	Major facilitator Superfamily
I6H59_RS03545	COG0237	dephospho-CoA kinase activity
I6H59_RS03550	COG1882	Formate acetyltransferase
I6H59_RS03555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H59_RS03560	COG0542	response to heat
I6H59_RS03565	COG4463	regulation of RNA biosynthetic process
I6H59_RS03570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H59_RS03575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H59_RS03580	COG3343	RNA polymerase activity
I6H59_RS03585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H59_RS03590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H59_RS03590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H59_RS03595	COG0300	oxidoreductase activity
I6H59_RS03600	COG1234	tRNA 3'-trailer cleavage
I6H59_RS03625	COG0640	Transcriptional regulator
I6H59_RS03630	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H59_RS03640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H59_RS03645	COG0483	inositol monophosphate 1-phosphatase activity
I6H59_RS03650	COG4476	Belongs to the UPF0223 family
I6H59_RS03655	COG1393	Belongs to the ArsC family
I6H59_RS03660	COG4474	Belongs to the UPF0398 family
I6H59_RS03665	COG0582	viral genome integration into host DNA
I6H59_RS03705	COG0433	COG0433 Predicted ATPase
I6H59_RS03750	COG2946	Replication initiation factor
I6H59_RS03760	COG1674	ftsk spoiiie
I6H59_RS03795	COG1396	sequence-specific DNA binding
I6H59_RS03820	COG1199	ATP-dependent helicase activity
I6H59_RS03820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H59_RS03870	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H59_RS03870	COG1388	LysM domain
I6H59_RS03880	COG1104	cysteine desulfurase activity
I6H59_RS03885	COG0776	regulation of translation
I6H59_RS03895	COG2755	lipolytic protein G-D-S-L family
I6H59_RS03900	COG1307	EDD domain protein, DegV family
I6H59_RS03905	COG1272	protein, Hemolysin III
I6H59_RS03910	COG0587	DNA-directed DNA polymerase activity
I6H59_RS03920	COG0110	maltose O-acetyltransferase activity
I6H59_RS03925	COG0504	CTP synthase activity
I6H59_RS03930	COG4475	Protein of unknown function (DUF436)
I6H59_RS03935	COG4720	Psort location CytoplasmicMembrane, score
I6H59_RS03975	COG1316	TRANSCRIPTIONal
I6H59_RS03985	COG0802	atpase or kinase
I6H59_RS03990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H59_RS04005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H59_RS04005	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H59_RS04005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H59_RS04005	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H59_RS04010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H59_RS04020	COG0395	ABC-type sugar transport system, permease component
I6H59_RS04030	COG1653	transport
I6H59_RS04035	COG1554	hydrolase, family 65, central catalytic
I6H59_RS04050	COG1609	Transcriptional regulator
I6H59_RS04055	COG3842	ATPase activity
I6H59_RS04065	COG1597	lipid kinase activity
I6H59_RS04070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H59_RS04085	COG1132	(ABC) transporter
I6H59_RS04100	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H59_RS04105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS04110	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS04115	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS04120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS04125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS04140	COG0513	Belongs to the DEAD box helicase family
I6H59_RS04145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H59_RS04150	COG1304	FMN binding
I6H59_RS04165	COG0589	response to stress
I6H59_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H59_RS04195	COG1774	PSP1 C-terminal conserved region
I6H59_RS04200	COG0470	DNA polymerase III
I6H59_RS04210	COG0745	RESPONSE REGULATOR receiver
I6H59_RS04215	COG5002	protein histidine kinase activity
I6H59_RS04220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H59_RS04225	COG0459	protein refolding
I6H59_RS04230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H59_RS04245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H59_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H59_RS04260	COG1363	Peptidase, m42
I6H59_RS04275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H59_RS04280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H59_RS04295	COG0025	NhaP-type Na H and K H
I6H59_RS04300	COG2814	Major facilitator Superfamily
I6H59_RS04305	COG0301	tRNA thio-modification
I6H59_RS04310	COG2855	membrane
I6H59_RS04325	COG0531	amino acid
I6H59_RS04330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H59_RS04335	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6H59_RS04345	COG3976	FMN-binding domain protein
I6H59_RS04345	COG0431	NADPH-dependent FMN reductase
I6H59_RS04345	COG1053	succinate dehydrogenase
I6H59_RS04355	COG0833	amino acid
I6H59_RS04365	COG0564	pseudouridine synthase activity
I6H59_RS04370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H59_RS04375	COG2357	RelA SpoT domain protein
I6H59_RS04390	COG4471	UPF0298 protein
I6H59_RS04400	COG1113	amino acid transport
I6H59_RS04405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H59_RS04410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H59_RS04425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS04430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H59_RS04460	COG0513	Belongs to the DEAD box helicase family
I6H59_RS04470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H59_RS04480	COG4608	Belongs to the ABC transporter superfamily
I6H59_RS04485	COG0444	Belongs to the ABC transporter superfamily
I6H59_RS04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H59_RS04495	COG0601	transmembrane transport
I6H59_RS04500	COG4166	transmembrane transport
I6H59_RS04505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H59_RS04510	COG1937	Protein conserved in bacteria
I6H59_RS04520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H59_RS04530	COG0583	DNA-binding transcription factor activity
I6H59_RS04540	COG0768	penicillin binding
I6H59_RS04545	COG0588	phosphoglycerate mutase activity
I6H59_RS04550	COG0583	DNA-binding transcription factor activity
I6H59_RS04570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H59_RS04585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H59_RS04625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H59_RS04635	COG0686	Belongs to the AlaDH PNT family
I6H59_RS04645	COG4956	integral membrane protein (PIN domain superfamily)
I6H59_RS04670	COG0203	ribosomal protein L17
I6H59_RS04675	COG0202	RNA polymerase activity
I6H59_RS04680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H59_RS04685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H59_RS04695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H59_RS04700	COG1846	Transcriptional regulator
I6H59_RS04705	COG1121	(ABC) transporter
I6H59_RS04710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H59_RS04715	COG0563	adenylate kinase activity
I6H59_RS04725	COG0200	Binds to the 23S rRNA
I6H59_RS04730	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H59_RS04735	COG1841	ribosomal large subunit assembly
I6H59_RS04740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H59_RS04745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H59_RS04755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H59_RS04760	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6H59_RS04765	COG0039	L-malate dehydrogenase activity
I6H59_RS04770	COG1393	Belongs to the ArsC family
I6H59_RS04775	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H59_RS04780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H59_RS04785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H59_RS04790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H59_RS04795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H59_RS04805	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H59_RS04815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H59_RS04820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H59_RS04825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H59_RS04830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H59_RS04840	COG0088	Forms part of the polypeptide exit tunnel
I6H59_RS04845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H59_RS04850	COG0051	transcription antitermination factor activity, RNA binding
I6H59_RS04855	COG1970	mechanosensitive ion channel activity
I6H59_RS04860	COG0534	Mate efflux family protein
I6H59_RS04865	COG0250	Participates in transcription elongation, termination and antitermination
I6H59_RS04875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H59_RS04885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H59_RS04890	COG0564	pseudouridine synthase activity
I6H59_RS04895	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H59_RS04895	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H59_RS04925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H59_RS04930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H59_RS04970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H59_RS04975	COG3475	LICD family
I6H59_RS04980	COG1216	Glycosyl transferase, family 2
I6H59_RS04980	COG1442	glycosyl transferase family 8
I6H59_RS05005	COG0438	transferase activity, transferring glycosyl groups
I6H59_RS05010	COG1215	transferase activity, transferring glycosyl groups
I6H59_RS05035	COG0463	Glycosyl transferase, family 2
I6H59_RS05050	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H59_RS05065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6H59_RS05070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H59_RS05080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H59_RS05090	COG1461	Dihydroxyacetone kinase
I6H59_RS05110	COG0142	geranyltranstransferase activity
I6H59_RS05120	COG0436	Aminotransferase
I6H59_RS05135	COG0531	amino acid
I6H59_RS05140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H59_RS05145	COG2235	arginine
I6H59_RS05150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H59_RS05155	COG4470	Protein conserved in bacteria
I6H59_RS05165	COG0756	dUTP diphosphatase activity
I6H59_RS05175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H59_RS05185	COG0534	Mate efflux family protein
I6H59_RS05190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H59_RS05195	COG0154	amidase activity
I6H59_RS05205	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6H59_RS05225	COG4472	Bacterial protein of unknown function (DUF965)
I6H59_RS05230	COG4989	oxidoreductase activity
I6H59_RS05235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H59_RS05245	COG0706	membrane insertase activity
I6H59_RS05250	COG0594	ribonuclease P activity
I6H59_RS05265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H59_RS05270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H59_RS05280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H59_RS05285	COG0653	protein targeting
I6H59_RS05290	COG0204	Acyl-transferase
I6H59_RS05295	COG1011	Hydrolase
I6H59_RS05300	COG1490	D-aminoacyl-tRNA deacylase activity
I6H59_RS05310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H59_RS05315	COG2264	protein methyltransferase activity
I6H59_RS05325	COG0454	-acetyltransferase
I6H59_RS05330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H59_RS05340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H59_RS05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H59_RS05350	COG2814	Major facilitator Superfamily
I6H59_RS05380	COG0488	(ABC) transporter
I6H59_RS05390	COG0416	fatty acid biosynthetic process
I6H59_RS05395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H59_RS05400	COG1764	response to oxidative stress
I6H59_RS05405	COG0180	Tryptophanyl-tRNA synthetase
I6H59_RS05410	COG1418	mRNA catabolic process
I6H59_RS05415	COG0584	glycerophosphoryl diester phosphodiesterase
I6H59_RS05495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H59_RS05500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H59_RS05505	COG0037	tRNA processing
I6H59_RS05515	COG2368	4-hydroxyphenylacetate
I6H59_RS05530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H59_RS05535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H59_RS05540	COG0193	aminoacyl-tRNA hydrolase activity
I6H59_RS05545	COG0012	GTP binding
I6H59_RS05550	COG4481	Protein conserved in bacteria
I6H59_RS05555	COG1074	ATP-dependent DNA helicase activity
I6H59_RS05560	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H59_RS05565	COG0592	DNA-directed DNA polymerase activity
I6H59_RS05570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H59_RS05575	COG1475	DNA binding
I6H59_RS05610	COG1242	4 iron, 4 sulfur cluster binding
I6H59_RS05615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H59_RS05620	COG4975	Glucose uptake
I6H59_RS05625	COG0531	amino acid
I6H59_RS05630	COG1686	Belongs to the peptidase S11 family
I6H59_RS05640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H59_RS05645	COG0049	tRNA binding
I6H59_RS05660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H59_RS05665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H59_RS05675	COG0681	Belongs to the peptidase S26 family
I6H59_RS05680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H59_RS05685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H59_RS05690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H59_RS05755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H59_RS05775	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H59_RS05780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H59_RS05790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H59_RS05795	COG1187	pseudouridine synthase activity
I6H59_RS05810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H59_RS05820	COG1792	Involved in formation and maintenance of cell shape
I6H59_RS05830	COG3883	PFAM NLP P60 protein
I6H59_RS05830	COG3942	CHAP domain
I6H59_RS05835	COG3883	PFAM NLP P60 protein
I6H59_RS05835	COG3942	CHAP domain
I6H59_RS05845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H59_RS05850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H59_RS05860	COG0730	response to heat
I6H59_RS05880	COG2084	Dehydrogenase
I6H59_RS05900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H59_RS05910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H59_RS05915	COG0463	Glycosyl transferase, family 2
I6H59_RS05925	COG2255	four-way junction helicase activity
I6H59_RS05930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H59_RS05935	COG0789	Transcriptional regulator
I6H59_RS05940	COG0174	glutamine synthetase
I6H59_RS05965	COG0582	viral genome integration into host DNA
I6H59_RS06035	COG0629	single-stranded DNA binding
I6H59_RS06145	COG1783	phage Terminase large subunit
I6H59_RS06275	COG3299	homolog of phage Mu protein gp47
I6H59_RS06285	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6H59_RS06300	COG5263	repeat protein
I6H59_RS06300	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6H59_RS06315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H59_RS06320	COG0833	amino acid
I6H59_RS06330	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H59_RS06335	COG0629	single-stranded DNA binding
I6H59_RS06340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H59_RS06345	COG1408	metallophosphoesterase
I6H59_RS06360	COG2137	regulation of response to DNA damage stimulus
I6H59_RS06365	COG2814	Major facilitator Superfamily
I6H59_RS06370	COG0656	L-ascorbic acid biosynthetic process
I6H59_RS06375	COG1733	regulation of RNA biosynthetic process
I6H59_RS06380	COG0346	lactoylglutathione lyase activity
I6H59_RS06385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H59_RS06410	COG0525	valine-tRNA ligase activity
I6H59_RS06415	COG0166	Belongs to the GPI family
I6H59_RS06420	COG0742	ribosomal rna small subunit methyltransferase
I6H59_RS06430	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H59_RS06435	COG1454	alcohol dehydrogenase
I6H59_RS06435	COG1012	belongs to the aldehyde dehydrogenase family
I6H59_RS06440	COG2706	6-phosphogluconolactonase activity
I6H59_RS06445	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H59_RS06450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H59_RS06455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6H59_RS06460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H59_RS06465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H59_RS06470	COG1534	Rna-binding protein
I6H59_RS06480	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H59_RS06485	COG0799	negative regulation of ribosome biogenesis
I6H59_RS06490	COG2226	methyltransferase
I6H59_RS06495	COG1323	Belongs to the UPF0348 family
I6H59_RS06500	COG0217	transcriptional regulatory protein
I6H59_RS06525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H59_RS06525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H59_RS06530	COG2814	Major facilitator Superfamily
I6H59_RS06540	COG0343	queuine tRNA-ribosyltransferase activity
I6H59_RS06545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H59_RS06550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H59_RS06555	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H59_RS06565	COG0438	transferase activity, transferring glycosyl groups
I6H59_RS06575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H59_RS06595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H59_RS06600	COG4589	Belongs to the CDS family
I6H59_RS06605	COG0750	zinc metalloprotease
I6H59_RS06610	COG0442	prolyl-tRNA aminoacylation
I6H59_RS06620	COG2176	DNA-directed DNA polymerase activity
I6H59_RS06690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H59_RS06720	COG2081	HI0933 family
I6H59_RS06730	COG0517	IMP dehydrogenase activity
I6H59_RS06730	COG1125	glycine betaine transport
I6H59_RS06735	COG0673	inositol 2-dehydrogenase activity
I6H59_RS06745	COG1854	S-ribosylhomocysteine lyase activity
I6H59_RS06750	COG0656	L-ascorbic acid biosynthetic process
I6H59_RS06775	COG0531	amino acid
I6H59_RS06780	COG1335	isochorismatase
I6H59_RS06785	COG1328	CTP reductase activity
I6H59_RS06785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H59_RS06790	COG0531	amino acid
I6H59_RS06805	COG1122	ATPase activity
I6H59_RS06810	COG1122	ATPase activity
I6H59_RS06815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H59_RS06865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H59_RS06875	COG1393	Belongs to the ArsC family
I6H59_RS06910	COG1396	sequence-specific DNA binding
I6H59_RS06955	COG3716	PTS system mannose fructose sorbose family IID component
I6H59_RS06965	COG1737	Transcriptional regulator
I6H59_RS06970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H59_RS06975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H59_RS06985	COG2183	response to ionizing radiation
I6H59_RS06990	COG3091	SprT-like family
I6H59_RS07020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H59_RS07035	COG5503	Protein of unknown function (DUF1447)
I6H59_RS07040	COG1214	PFAM Peptidase M22, glycoprotease
I6H59_RS07050	COG0456	acetyltransferase
I6H59_RS07070	COG0308	aminopeptidase N
I6H59_RS07085	COG1846	Transcriptional regulator
I6H59_RS07090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H59_RS07095	COG1132	(ABC) transporter
I6H59_RS07100	COG1132	(ABC) transporter
I6H59_RS07110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H59_RS07115	COG4443	Transcriptional Coactivator p15 (PC4)
I6H59_RS07125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H59_RS07130	COG3859	Proton-coupled thiamine transporter YuaJ
I6H59_RS07135	COG1266	CAAX protease self-immunity
I6H59_RS07145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H59_RS07150	COG1113	amino acid transport
I6H59_RS07155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H59_RS07165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H59_RS07185	COG0783	Belongs to the Dps family
I6H59_RS07190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H59_RS07195	COG1940	carbohydrate kinase activity
I6H59_RS07205	COG1217	gtp-binding protein TYPA
I6H59_RS07215	COG0827	DNA restriction-modification system
I6H59_RS07220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H59_RS07225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H59_RS07235	COG0233	cytoplasmic translational termination
I6H59_RS07250	COG4479	Belongs to the UPF0346 family
I6H59_RS07270	COG0577	efflux transmembrane transporter activity
I6H59_RS07270	COG1136	(ABC) transporter
I6H59_RS07280	COG0081	regulation of translation
I6H59_RS07290	COG0537	adenosine 5'-monophosphoramidase activity
I6H59_RS07310	COG1131	(ABC) transporter
I6H59_RS07315	COG4473	ABC transporter
I6H59_RS07325	COG2226	methyltransferase
I6H59_RS07345	COG0826	peptidase U32
I6H59_RS07365	COG2017	converts alpha-aldose to the beta-anomer
I6H59_RS07380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H59_RS07385	COG0531	amino acid
I6H59_RS07395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H59_RS07400	COG2501	S4 domain
I6H59_RS07405	COG0612	Peptidase, M16
I6H59_RS07410	COG0612	Peptidase, M16
I6H59_RS07415	COG1426	Protein conserved in bacteria
I6H59_RS07425	COG0124	histidyl-tRNA synthetase
I6H59_RS07430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H59_RS07435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H59_RS07440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H59_RS07450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H59_RS07455	COG0038	chloride channel
I6H59_RS07460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H59_RS07475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H59_RS07480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H59_RS07480	COG0072	phenylalanine-tRNA ligase activity
I6H59_RS07485	COG1388	LysM domain
I6H59_RS07485	COG3584	3D domain protein
I6H59_RS07500	COG3655	Transcriptional regulator
I6H59_RS07510	COG1162	GTPase activity
I6H59_RS07520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H59_RS07545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H59_RS07575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H59_RS07580	COG0191	fructose-bisphosphate aldolase activity
I6H59_RS07590	COG3711	transcriptional antiterminator
I6H59_RS07595	COG2190	(PTS) system
I6H59_RS07595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS07595	COG1263	PTS System
I6H59_RS07600	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS07605	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS07610	COG0596	Alpha beta hydrolase
I6H59_RS07615	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H59_RS07615	COG3942	CHAP domain
I6H59_RS07635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H59_RS07635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H59_RS07640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H59_RS07645	COG1418	mRNA catabolic process
I6H59_RS07650	COG0194	GDP metabolic process
I6H59_RS07660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H59_RS07665	COG1428	Deoxynucleoside kinase
I6H59_RS07670	COG1611	Belongs to the LOG family
I6H59_RS07680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H59_RS07685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H59_RS07685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H59_RS07690	COG0631	protein serine/threonine phosphatase activity
I6H59_RS07695	COG2815	serine threonine protein kinase
I6H59_RS07695	COG0515	serine threonine protein kinase
I6H59_RS07700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H59_RS07705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H59_RS07715	COG0494	nUDIX hydrolase
I6H59_RS07725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H59_RS07740	COG1307	EDD domain protein, DegV family
I6H59_RS07750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H59_RS07755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H59_RS07760	COG1799	cell septum assembly
I6H59_RS07765	COG0762	integral membrane protein
I6H59_RS07775	COG3599	regulation of cell shape
I6H59_RS07780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H59_RS07795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H59_RS07805	COG1104	cysteine desulfurase activity
I6H59_RS07815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H59_RS07820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H59_RS07825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H59_RS07830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H59_RS07835	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H59_RS07840	COG1045	serine acetyltransferase
I6H59_RS07850	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H59_RS07865	COG0445	tRNA wobble uridine modification
I6H59_RS07965	COG0358	DNA primase activity
I6H59_RS07970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H59_RS07975	COG0542	response to heat
I6H59_RS07985	COG0242	peptide deformylase activity
I6H59_RS07990	COG0494	nUDIX hydrolase
I6H59_RS07995	COG0556	nucleotide-excision repair
I6H59_RS08000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H59_RS08005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H59_RS08010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H59_RS08020	COG2814	Major facilitator Superfamily
I6H59_RS08025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H59_RS08030	COG0706	membrane insertase activity
I6H59_RS08035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H59_RS08040	COG4684	Psort location CytoplasmicMembrane, score
I6H59_RS08045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H59_RS08060	COG1942	4-Oxalocrotonate Tautomerase
I6H59_RS08095	COG0577	efflux transmembrane transporter activity
I6H59_RS08125	COG2199	diguanylate cyclase activity
I6H59_RS08130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H59_RS08135	COG3158	transport of potassium into the cell
I6H59_RS08160	COG1846	Transcriptional regulator
I6H59_RS08165	COG0778	Nitroreductase
I6H59_RS08175	COG1846	Transcriptional regulator
I6H59_RS08180	COG1266	CAAX protease self-immunity
I6H59_RS08195	COG0531	amino acid
I6H59_RS08200	COG0076	glutamate decarboxylase activity
I6H59_RS08205	COG0436	Aminotransferase
I6H59_RS08220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H59_RS08225	COG2171	N-acyltransferase activity
I6H59_RS08230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H59_RS08235	COG0527	aspartate kinase activity
I6H59_RS08240	COG1473	amidohydrolase
I6H59_RS08300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H59_RS08310	COG1620	l-lactate permease
I6H59_RS08345	COG1435	thymidine kinase activity
I6H59_RS08360	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H59_RS08375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H59_RS08385	COG1254	Belongs to the acylphosphatase family
I6H59_RS08390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H59_RS08395	COG0716	FMN binding
I6H59_RS08400	COG0024	Methionine aminopeptidase
I6H59_RS08425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H59_RS08430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H59_RS08450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H59_RS08455	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H59_RS08460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H59_RS08465	COG1121	(ABC) transporter
I6H59_RS08470	COG0167	dihydroorotate dehydrogenase activity
I6H59_RS08500	COG0726	polysaccharide deacetylase
I6H59_RS08505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H59_RS08520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6H59_RS08520	COG3583	domain protein
I6H59_RS08520	COG3064	Membrane
I6H59_RS08535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H59_RS08540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H59_RS08545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H59_RS08555	COG0148	phosphopyruvate hydratase activity
I6H59_RS08565	COG2514	catechol 2,3-dioxygenase activity
I6H59_RS08570	COG4129	membrane
I6H59_RS08590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6H59_RS08590	COG0392	lysyltransferase activity
I6H59_RS08600	COG1199	ATP-dependent helicase activity
I6H59_RS08600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H59_RS08610	COG0436	Aminotransferase
I6H59_RS08620	COG0017	Asparaginyl-tRNA synthetase
I6H59_RS08640	COG0393	Putative heavy-metal-binding
I6H59_RS08645	COG2827	Endonuclease containing a URI domain
I6H59_RS08650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H59_RS08655	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H59_RS08680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS08685	COG3715	PTS system
I6H59_RS08690	COG3716	PTS system mannose fructose sorbose family IID component
I6H59_RS08700	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H59_RS08705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS08705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS08705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS08710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H59_RS08715	COG2222	sugar isomerase
I6H59_RS08720	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H59_RS08725	COG0191	fructose-bisphosphate aldolase activity
I6H59_RS08730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H59_RS08735	COG0006	proline dipeptidase activity
I6H59_RS08740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H59_RS08750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H59_RS08760	COG1271	oxidase subunit
I6H59_RS08765	COG1294	oxidase, subunit
I6H59_RS08770	COG4988	ABC transporter
I6H59_RS08775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H59_RS08785	COG1136	(ABC) transporter
I6H59_RS08785	COG0577	efflux transmembrane transporter activity
I6H59_RS08845	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6H59_RS08860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H59_RS08865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H59_RS08870	COG2274	protein secretion by the type I secretion system
I6H59_RS08885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H59_RS08905	COG3344	reverse transcriptase
I6H59_RS08995	COG1164	Oligoendopeptidase f
I6H59_RS09075	COG0247	lactate metabolic process
I6H59_RS09085	COG1234	tRNA 3'-trailer cleavage
I6H59_RS09115	COG0235	Class ii aldolase
I6H59_RS09120	COG3254	rhamnose metabolic process
I6H59_RS09140	COG0318	PFAM AMP-dependent synthetase and ligase
I6H59_RS09145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H59_RS09150	COG2267	carboxylic ester hydrolase activity
I6H59_RS09155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H59_RS09160	COG1169	isochorismate synthase
I6H59_RS09170	COG4109	DRTGG domain
I6H59_RS09175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H59_RS09195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H59_RS09235	COG0252	asparaginase activity
I6H59_RS09240	COG0561	phosphatase activity
I6H59_RS09245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H59_RS09255	COG0359	binds to the 23S rRNA
I6H59_RS09260	COG0305	Participates in initiation and elongation during chromosome replication
I6H59_RS09275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H59_RS09280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H59_RS09290	COG1484	DNA-dependent DNA replication
I6H59_RS09305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS09330	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H59_RS09360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H59_RS09365	COG0569	domain protein
I6H59_RS09370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H59_RS09375	COG0628	permease
I6H59_RS09380	COG1160	GTP binding
I6H59_RS09385	COG1346	cytolysis
I6H59_RS09390	COG1380	Effector of murein hydrolase LrgA
I6H59_RS09395	COG0779	Required for maturation of 30S ribosomal subunits
I6H59_RS09400	COG0195	Participates in both transcription termination and antitermination
I6H59_RS09405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H59_RS09415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H59_RS09420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H59_RS09435	COG1482	cell wall glycoprotein biosynthetic process
I6H59_RS09465	COG0673	inositol 2-dehydrogenase activity
I6H59_RS09470	COG0572	uridine kinase
I6H59_RS09475	COG0280	phosphate acetyltransferase
I6H59_RS09485	COG0571	ribonuclease III activity
I6H59_RS09490	COG1196	nuclear chromosome segregation
I6H59_RS09495	COG1368	sulfuric ester hydrolase activity
I6H59_RS09530	COG0561	phosphatase activity
I6H59_RS09535	COG0552	protein localization to endoplasmic reticulum
I6H59_RS09540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H59_RS09555	COG0596	Alpha beta hydrolase
I6H59_RS09580	COG0318	PFAM AMP-dependent synthetase and ligase
I6H59_RS09585	COG1760	l-serine dehydratase
I6H59_RS09595	COG3682	Transcriptional regulator
I6H59_RS09600	COG2217	Heavy metal translocating P-type atpase
I6H59_RS09605	COG2217	Heavy metal translocating P-type atpase
I6H59_RS09610	COG0514	ATP-dependent DNA helicase (RecQ)
I6H59_RS09615	COG1446	asparaginase
I6H59_RS09620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS09640	COG2188	Transcriptional regulator
I6H59_RS09655	COG0482	sulfurtransferase activity
I6H59_RS09665	COG0539	negative regulation of cytoplasmic translation
I6H59_RS09685	COG0366	Alpha amylase catalytic
I6H59_RS09690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H59_RS09695	COG1070	Carbohydrate kinase
I6H59_RS09700	COG2610	gluconate transmembrane transporter activity
I6H59_RS09705	COG1757	Na H antiporter
I6H59_RS09710	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H59_RS09720	COG0540	Belongs to the ATCase OTCase family
I6H59_RS09725	COG0505	Belongs to the CarA family
I6H59_RS09730	COG1268	BioY protein
I6H59_RS09735	COG1393	Belongs to the ArsC family
I6H59_RS09745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H59_RS09760	COG1134	teichoic acid transport
I6H59_RS09760	COG1388	LysM domain
I6H59_RS09765	COG1682	transport, permease protein
I6H59_RS09795	COG1215	transferase activity, transferring glycosyl groups
I6H59_RS09795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H59_RS09800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H59_RS09810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H59_RS09810	COG0463	Glycosyl transferase, family 2
I6H59_RS09825	COG1316	TRANSCRIPTIONal
I6H59_RS09830	COG0363	glucosamine-6-phosphate deaminase activity
I6H59_RS09835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H59_RS09840	COG1309	transcriptional regulator
I6H59_RS09850	COG0673	inositol 2-dehydrogenase activity
I6H59_RS09860	COG2188	Transcriptional regulator
I6H59_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
I6H59_RS09870	COG3425	synthase
I6H59_RS09875	COG0183	Belongs to the thiolase family
I6H59_RS09885	COG0228	four-way junction DNA binding
I6H59_RS09890	COG1837	Belongs to the UPF0109 family
I6H59_RS09900	COG3479	Phenolic acid decarboxylase
I6H59_RS09910	COG1253	flavin adenine dinucleotide binding
I6H59_RS09915	COG1053	succinate dehydrogenase
I6H59_RS09940	COG2261	transglycosylase associated protein
I6H59_RS09945	COG0686	Belongs to the AlaDH PNT family
I6H59_RS09950	COG2261	transglycosylase associated protein
I6H59_RS09960	COG2323	membrane
I6H59_RS09970	COG0531	amino acid
I6H59_RS09975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H59_RS09980	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H59_RS09995	COG1307	EDD domain protein, DegV family
I6H59_RS10000	COG1288	antiporter activity
I6H59_RS10005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H59_RS10010	COG0617	tRNA 3'-terminal CCA addition
I6H59_RS10015	COG4690	dipeptidase activity
I6H59_RS10025	COG0488	(ABC) transporter
I6H59_RS10030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H59_RS10035	COG0454	-acetyltransferase
I6H59_RS10045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H59_RS10060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H59_RS10065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H59_RS10070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H59_RS10075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H59_RS10090	COG2188	Transcriptional regulator
I6H59_RS10100	COG2190	(PTS) system
I6H59_RS10100	COG1263	PTS System
I6H59_RS10100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS10105	COG0366	Alpha amylase catalytic
I6H59_RS10110	COG1011	Hydrolase
I6H59_RS10115	COG0151	Belongs to the GarS family
I6H59_RS10135	COG0346	lactoylglutathione lyase activity
I6H59_RS10140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H59_RS10145	COG0589	response to stress
I6H59_RS10155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H59_RS10155	COG0519	Catalyzes the synthesis of GMP from XMP
I6H59_RS10160	COG1072	(Pantothenic acid kinase))
I6H59_RS10165	COG2813	Specifically methylates the guanine in position
I6H59_RS10180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H59_RS10190	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H59_RS10195	COG2188	Transcriptional regulator
I6H59_RS10205	COG0745	RESPONSE REGULATOR receiver
I6H59_RS10210	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H59_RS10220	COG1131	(ABC) transporter
I6H59_RS10270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H59_RS10285	COG0589	response to stress
I6H59_RS10325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H59_RS10330	COG0517	IMP dehydrogenase activity
I6H59_RS10335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H59_RS10335	COG0574	Belongs to the PEP-utilizing enzyme family
I6H59_RS10355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H59_RS10375	COG2094	Belongs to the DNA glycosylase MPG family
I6H59_RS10380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H59_RS10385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H59_RS10390	COG0668	transmembrane transport
I6H59_RS10395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H59_RS10400	COG3763	UPF0154 protein
I6H59_RS10405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H59_RS10420	COG4974	Belongs to the 'phage' integrase family
I6H59_RS10425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H59_RS10430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H59_RS10435	COG1187	pseudouridine synthase activity
I6H59_RS10440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H59_RS10460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H59_RS10465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H59_RS10470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H59_RS10485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H59_RS10485	COG0302	gtp cyclohydrolase
I6H59_RS10490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H59_RS10495	COG1051	belongs to the nudix hydrolase family
I6H59_RS10500	COG0285	dihydrofolate synthase activity
I6H59_RS10505	COG1428	Deoxynucleoside kinase
I6H59_RS10510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H59_RS10515	COG2003	Belongs to the UPF0758 family
I6H59_RS10525	COG0583	DNA-binding transcription factor activity
I6H59_RS10530	COG0281	malic enzyme
I6H59_RS10555	COG3935	DnaD domain protein
I6H59_RS10560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H59_RS10565	COG2384	SAM-dependent methyltransferase
I6H59_RS10570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H59_RS10580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H59_RS10585	COG2226	methyltransferase
I6H59_RS10590	COG0628	permease
I6H59_RS10600	COG0028	Belongs to the TPP enzyme family
I6H59_RS10620	COG3397	chitin binding
I6H59_RS10635	COG1263	PTS System
I6H59_RS10635	COG2190	(PTS) system
I6H59_RS10635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H59_RS10645	COG1695	Transcriptional regulator
I6H59_RS10675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H59_RS10680	COG0626	cystathionine gamma-synthase activity
I6H59_RS10700	COG0450	alkyl hydroperoxide reductase
I6H59_RS10705	COG3634	alkyl hydroperoxide reductase activity
I6H59_RS10715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H59_RS10730	COG4175	Glycine betaine
I6H59_RS10730	COG3448	diguanylate cyclase activity
I6H59_RS10740	COG3527	Alpha-acetolactate decarboxylase
I6H59_RS10745	COG0758	DNA mediated transformation
I6H59_RS10750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H59_RS10755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6H59_RS10760	COG4974	Belongs to the 'phage' integrase family
I6H59_RS10795	COG1309	transcriptional regulator
I6H59_RS10815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H59_RS10820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H59_RS10825	COG1696	Membrane protein involved in D-alanine export
I6H59_RS10830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H59_RS10845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H59_RS10880	COG1162	GTPase activity
I6H59_RS10885	COG4975	Glucose uptake
I6H59_RS10890	COG1869	D-ribose catabolic process
I6H59_RS10900	COG1609	Transcriptional regulator
I6H59_RS10905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H59_RS10915	COG3592	Divergent 4Fe-4S mono-cluster
I6H59_RS10925	COG1304	FMN binding
I6H59_RS10930	COG1393	Belongs to the ArsC family
I6H59_RS10935	COG2814	Major facilitator Superfamily
I6H59_RS10955	COG1940	carbohydrate kinase activity
I6H59_RS10960	COG2723	6-phospho-beta-galactosidase activity
I6H59_RS10975	COG0383	alpha-mannosidase activity
I6H59_RS10980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS10985	COG2188	Transcriptional regulator
I6H59_RS11010	COG0025	NhaP-type Na H and K H
I6H59_RS11015	COG0500	methyltransferase
I6H59_RS11030	COG0542	response to heat
I6H59_RS11035	COG2910	NAD(P)H-binding
I6H59_RS11040	COG1959	2 iron, 2 sulfur cluster binding
I6H59_RS11050	COG2814	Major facilitator Superfamily
I6H59_RS11055	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H59_RS11055	COG2918	glutathione biosynthetic process
I6H59_RS11060	COG1764	response to oxidative stress
I6H59_RS11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H59_RS11110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS11145	COG4974	Belongs to the 'phage' integrase family
I6H59_RS11155	COG1396	sequence-specific DNA binding
I6H59_RS11170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS11170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H59_RS11175	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H59_RS11205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS11210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS11210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H59_RS11210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H59_RS11215	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H59_RS11220	COG1737	Transcriptional regulator
I6H59_RS11225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H59_RS11240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H59_RS11295	COG2801	Transposase and inactivated derivatives
I6H59_RS11315	COG3843	relaxase mobilization nuclease domain protein
I6H59_RS11375	COG1388	LysM domain
I6H59_RS11375	COG3942	CHAP domain
I6H59_RS11425	COG0222	ribosome binding
I6H59_RS11430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H59_RS11435	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H59_RS11440	COG0025	NhaP-type Na H and K H
I6H59_RS11465	COG5001	Diguanylate cyclase
I6H59_RS11475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H59_RS11485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H59_RS11490	COG0842	Transport permease protein
I6H59_RS11495	COG1131	(ABC) transporter
I6H59_RS11555	COG1192	Involved in chromosome partitioning
I6H59_RS11570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H59_RS11580	COG1393	Belongs to the ArsC family
I6H59_RS11620	COG0791	NLP P60 protein
I6H59_RS11620	COG0741	lytic transglycosylase activity