locus-tag	class	description
LLH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LLH_RS00010	COG0592	DNA-directed DNA polymerase activity
LLH_RS00035	COG0012	GTP binding
LLH_RS00055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LLH_RS00060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LLH_RS00080	COG0037	tRNA processing
LLH_RS00085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LLH_RS00090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LLH_RS00145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LLH_RS00170	COG3328	transposase activity
LLH_RS00195	COG2801	Transposase and inactivated derivatives
LLH_RS00200	COG2963	transposase activity
LLH_RS00205	COG0454	-acetyltransferase
LLH_RS00215	COG0659	secondary active sulfate transmembrane transporter activity
LLH_RS00220	COG3153	acetyltransferase
LLH_RS00230	COG0436	Aminotransferase
LLH_RS00245	COG0508	dehydrogenase complex catalyzes the overall conversion of
LLH_RS00260	COG0095	Lipoate-protein ligase
LLH_RS00265	COG0584	glycerophosphoryl diester phosphodiesterase
LLH_RS00270	COG1418	mRNA catabolic process
LLH_RS00275	COG2801	Transposase and inactivated derivatives
LLH_RS00285	COG2801	Transposase and inactivated derivatives
LLH_RS00305	COG0180	Tryptophanyl-tRNA synthetase
LLH_RS00310	COG1764	response to oxidative stress
LLH_RS00330	COG0488	(ABC) transporter
LLH_RS00340	COG4221	oxidoreductase activity
LLH_RS00345	COG1309	transcriptional regulator
LLH_RS00355	COG3328	transposase activity
LLH_RS00365	COG4221	oxidoreductase activity
LLH_RS00385	COG0400	carboxylic ester hydrolase activity
LLH_RS00390	COG0346	lactoylglutathione lyase activity
LLH_RS00395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LLH_RS00400	COG4974	Belongs to the 'phage' integrase family
LLH_RS00435	COG2801	Transposase and inactivated derivatives
LLH_RS00445	COG3328	transposase activity
LLH_RS00465	COG0489	protein tyrosine kinase activity
LLH_RS00470	COG4464	protein tyrosine phosphatase activity
LLH_RS00480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LLH_RS00505	COG1086	Polysaccharide biosynthesis protein
LLH_RS00520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LLH_RS00525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LLH_RS00530	COG0297	glycogen (starch) synthase activity
LLH_RS00530	COG0438	transferase activity, transferring glycosyl groups
LLH_RS00545	COG0438	transferase activity, transferring glycosyl groups
LLH_RS00585	COG2801	Transposase and inactivated derivatives
LLH_RS00605	COG2801	Transposase and inactivated derivatives
LLH_RS00610	COG2963	transposase activity
LLH_RS00620	COG1316	TRANSCRIPTIONal
LLH_RS00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LLH_RS00630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LLH_RS00635	COG2217	Heavy metal translocating P-type atpase
LLH_RS00645	COG1475	DNA binding
LLH_RS00650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LLH_RS00655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LLH_RS00665	COG0488	(ABC) transporter
LLH_RS00690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LLH_RS00695	COG0726	polysaccharide deacetylase
LLH_RS00720	COG1011	Hydrolase
LLH_RS00725	COG0531	amino acid
LLH_RS00730	COG0204	Acyl-transferase
LLH_RS00740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LLH_RS00745	COG0653	protein targeting
LLH_RS00750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LLH_RS00770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LLH_RS00800	COG2076	Multidrug Resistance protein
LLH_RS00805	COG2814	Major facilitator Superfamily
LLH_RS00810	COG2963	transposase activity
LLH_RS00815	COG2801	Transposase and inactivated derivatives
LLH_RS00850	COG0594	ribonuclease P activity
LLH_RS00855	COG0706	membrane insertase activity
LLH_RS00865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LLH_RS00870	COG4989	oxidoreductase activity
LLH_RS00880	COG1266	CAAX protease self-immunity
LLH_RS00885	COG4472	Bacterial protein of unknown function (DUF965)
LLH_RS00895	COG3906	Belongs to the UPF0473 family
LLH_RS00905	COG0300	oxidoreductase activity
LLH_RS00920	COG1309	transcriptional regulator
LLH_RS00925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LLH_RS00970	COG2801	Transposase and inactivated derivatives
LLH_RS01015	COG1832	CoA-binding protein
LLH_RS01040	COG0436	Aminotransferase
LLH_RS01045	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LLH_RS01055	COG0154	amidase activity
LLH_RS01080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LLH_RS01095	COG0346	lactoylglutathione lyase activity
LLH_RS01110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LLH_RS01125	COG2723	6-phospho-beta-galactosidase activity
LLH_RS01130	COG0756	dUTP diphosphatase activity
LLH_RS01135	COG0737	Belongs to the 5'-nucleotidase family
LLH_RS01140	COG4470	Protein conserved in bacteria
LLH_RS01155	COG0142	geranyltranstransferase activity
LLH_RS01185	COG1461	Dihydroxyacetone kinase
LLH_RS01195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LLH_RS01205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LLH_RS01225	COG1088	dTDP-glucose 4,6-dehydratase activity
LLH_RS01250	COG0463	Glycosyl transferase, family 2
LLH_RS01270	COG0463	Glycosyl transferase, family 2
LLH_RS01290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LLH_RS01345	COG0517	IMP dehydrogenase activity
LLH_RS01345	COG0516	GMP reductase activity
LLH_RS01350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LLH_RS01360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LLH_RS01365	COG1534	Rna-binding protein
LLH_RS01375	COG1713	HD superfamily hydrolase involved in NAD metabolism
LLH_RS01385	COG0799	negative regulation of ribosome biogenesis
LLH_RS01390	COG2226	methyltransferase
LLH_RS01395	COG1323	Belongs to the UPF0348 family
LLH_RS01405	COG0217	transcriptional regulatory protein
LLH_RS01415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LLH_RS01425	COG1309	transcriptional regulator
LLH_RS01430	COG0477	Major facilitator Superfamily
LLH_RS01435	COG0789	Transcriptional regulator
LLH_RS01440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LLH_RS01445	COG0561	phosphatase activity
LLH_RS01455	COG2376	Dihydroxyacetone kinase
LLH_RS01460	COG1309	transcriptional regulator
LLH_RS01465	COG2376	Dihydroxyacetone kinase
LLH_RS01470	COG1461	Dihydroxyacetone kinase
LLH_RS01475	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LLH_RS01480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LLH_RS01485	COG4690	dipeptidase activity
LLH_RS01490	COG1131	(ABC) transporter
LLH_RS01500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LLH_RS01505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LLH_RS01515	COG2081	HI0933 family
LLH_RS01520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LLH_RS01535	COG1132	(ABC) transporter
LLH_RS01545	COG0673	inositol 2-dehydrogenase activity
LLH_RS01550	COG1854	S-ribosylhomocysteine lyase activity
LLH_RS01560	COG0656	L-ascorbic acid biosynthetic process
LLH_RS01565	COG1335	isochorismatase
LLH_RS01590	COG0515	serine threonine protein kinase
LLH_RS01590	COG2815	serine threonine protein kinase
LLH_RS01600	COG1122	ATPase activity
LLH_RS01610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LLH_RS01635	COG0726	polysaccharide deacetylase
LLH_RS01655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LLH_RS01660	COG2183	response to ionizing radiation
LLH_RS01665	COG3091	SprT-like family
LLH_RS01670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LLH_RS01690	COG5503	Protein of unknown function (DUF1447)
LLH_RS01705	COG0456	acetyltransferase
LLH_RS01755	COG0737	Belongs to the 5'-nucleotidase family
LLH_RS01775	COG1846	Transcriptional regulator
LLH_RS01780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LLH_RS01790	COG1132	(ABC) transporter
LLH_RS01795	COG1132	(ABC) transporter
LLH_RS01800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LLH_RS01805	COG4443	Transcriptional Coactivator p15 (PC4)
LLH_RS01810	COG2963	transposase activity
LLH_RS01815	COG2801	Transposase and inactivated derivatives
LLH_RS01835	COG1268	BioY protein
LLH_RS01840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LLH_RS01845	COG3859	Proton-coupled thiamine transporter YuaJ
LLH_RS01850	COG1464	Belongs to the NlpA lipoprotein family
LLH_RS01860	COG1464	Belongs to the NlpA lipoprotein family
LLH_RS01870	COG1464	Belongs to the NlpA lipoprotein family
LLH_RS01880	COG2011	ABC-type metal ion transport system permease component
LLH_RS01905	COG1120	ATPase activity
LLH_RS01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LLH_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LLH_RS01920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LLH_RS01935	COG2814	Major facilitator Superfamily
LLH_RS01940	COG0656	L-ascorbic acid biosynthetic process
LLH_RS01945	COG1733	regulation of RNA biosynthetic process
LLH_RS01950	COG0346	lactoylglutathione lyase activity
LLH_RS01955	COG0588	phosphoglycerate mutase activity
LLH_RS01960	COG0450	alkyl hydroperoxide reductase
LLH_RS01965	COG3634	alkyl hydroperoxide reductase activity
LLH_RS01970	COG0768	penicillin binding
LLH_RS01985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LLH_RS01990	COG4166	transmembrane transport
LLH_RS01995	COG4166	transmembrane transport
LLH_RS02000	COG0601	transmembrane transport
LLH_RS02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LLH_RS02010	COG0444	Belongs to the ABC transporter superfamily
LLH_RS02015	COG4608	Belongs to the ABC transporter superfamily
LLH_RS02025	COG0513	Belongs to the DEAD box helicase family
LLH_RS02035	COG0367	asparagine synthase
LLH_RS02045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LLH_RS02050	COG1113	amino acid transport
LLH_RS02055	COG1113	amino acid transport
LLH_RS02085	COG3328	transposase activity
LLH_RS02090	COG2357	RelA SpoT domain protein
LLH_RS02100	COG0564	pseudouridine synthase activity
LLH_RS02110	COG0833	amino acid
LLH_RS02125	COG2801	Transposase and inactivated derivatives
LLH_RS02140	COG0583	DNA-binding transcription factor activity
LLH_RS02145	COG0583	DNA-binding transcription factor activity
LLH_RS02155	COG3328	transposase activity
LLH_RS02165	COG0583	DNA-binding transcription factor activity
LLH_RS02180	COG0301	tRNA thio-modification
LLH_RS02195	COG1764	response to oxidative stress
LLH_RS02200	COG0025	NhaP-type Na H and K H
LLH_RS02215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LLH_RS02220	COG1363	Peptidase, m42
LLH_RS02230	COG3118	belongs to the thioredoxin family
LLH_RS02235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LLH_RS02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
LLH_RS02260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LLH_RS02270	COG5002	protein histidine kinase activity
LLH_RS02275	COG0745	RESPONSE REGULATOR receiver
LLH_RS02285	COG0470	DNA polymerase III
LLH_RS02290	COG1774	PSP1 C-terminal conserved region
LLH_RS02320	COG1846	Transcriptional regulator
LLH_RS02325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LLH_RS02340	COG1304	FMN binding
LLH_RS02345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LLH_RS02350	COG1966	Carbon starvation protein
LLH_RS02355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LLH_RS02365	COG0513	Belongs to the DEAD box helicase family
LLH_RS02375	COG1737	Transcriptional regulator
LLH_RS02380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LLH_RS02385	COG1447	Phosphotransferase system cellobiose-specific component IIA
LLH_RS02395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LLH_RS02400	COG2723	6-phospho-beta-galactosidase activity
LLH_RS02420	COG1597	lipid kinase activity
LLH_RS02425	COG3842	ATPase activity
LLH_RS02455	COG2188	Transcriptional regulator
LLH_RS02460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LLH_RS02460	COG1263	PTS System
LLH_RS02460	COG2190	(PTS) system
LLH_RS02470	COG1554	hydrolase, family 65, central catalytic
LLH_RS02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LLH_RS02490	COG0802	atpase or kinase
LLH_RS02500	COG1316	TRANSCRIPTIONal
LLH_RS02515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LLH_RS02530	COG2801	Transposase and inactivated derivatives
LLH_RS02535	COG3328	transposase activity
LLH_RS02545	COG0463	Glycosyl transferase, family 2
LLH_RS02555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LLH_RS02555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LLH_RS02560	COG0631	protein serine/threonine phosphatase activity
LLH_RS02565	COG0515	serine threonine protein kinase
LLH_RS02565	COG2815	serine threonine protein kinase
LLH_RS02570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LLH_RS02575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LLH_RS02585	COG0494	nUDIX hydrolase
LLH_RS02595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LLH_RS02630	COG0656	L-ascorbic acid biosynthetic process
LLH_RS02635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LLH_RS02650	COG1307	EDD domain protein, DegV family
LLH_RS02655	COG0849	cell division
LLH_RS02660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LLH_RS02665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LLH_RS02680	COG2302	S4 RNA-binding domain
LLH_RS02685	COG3599	regulation of cell shape
LLH_RS02700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LLH_RS02710	COG1104	cysteine desulfurase activity
LLH_RS02715	COG0589	response to stress
LLH_RS02720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LLH_RS02740	COG1045	serine acetyltransferase
LLH_RS02755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LLH_RS02790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LLH_RS02795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LLH_RS02800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LLH_RS02805	COG0444	Belongs to the ABC transporter superfamily
LLH_RS02810	COG4608	Belongs to the ABC transporter superfamily
LLH_RS02815	COG0601	transmembrane transport
LLH_RS02820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LLH_RS02835	COG1199	ATP-dependent helicase activity
LLH_RS02835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LLH_RS02845	COG0436	Aminotransferase
LLH_RS02865	COG2801	Transposase and inactivated derivatives
LLH_RS02885	COG1564	THIamine pyrophosphokinase
LLH_RS02895	COG1113	amino acid transport
LLH_RS02900	COG2827	Endonuclease containing a URI domain
LLH_RS02910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LLH_RS02915	COG1573	uracil-dna glycosylase
LLH_RS02945	COG0628	permease
LLH_RS02950	COG1253	flavin adenine dinucleotide binding
LLH_RS02955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LLH_RS02960	COG1227	inorganic diphosphatase activity
LLH_RS02970	COG2195	Cleaves the N-terminal amino acid of tripeptides
LLH_RS02975	COG0531	amino acid
LLH_RS02980	COG2963	transposase activity
LLH_RS02985	COG2801	Transposase and inactivated derivatives
LLH_RS03000	COG3328	transposase activity
LLH_RS03005	COG0514	ATP-dependent DNA helicase (RecQ)
LLH_RS03010	COG1064	alcohol dehydrogenase
LLH_RS03025	COG2244	polysaccharide biosynthetic process
LLH_RS03035	COG3590	peptidase
LLH_RS03040	COG1396	sequence-specific DNA binding
LLH_RS03060	COG0085	RNA polymerase activity
LLH_RS03065	COG0765	amino acid transport
LLH_RS03070	COG1126	abc transporter atp-binding protein
LLH_RS03075	COG4862	establishment of competence for transformation
LLH_RS03080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LLH_RS03090	COG0719	Fe-S assembly protein
LLH_RS03095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LLH_RS03110	COG0719	Fe-S assembly protein
LLH_RS03115	COG0582	viral genome integration into host DNA
LLH_RS03175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LLH_RS03220	COG0756	dUTP diphosphatase activity
LLH_RS03360	COG1388	LysM domain
LLH_RS03360	COG1705	Flagellar rod assembly protein muramidase FlgJ
LLH_RS03375	COG4842	Belongs to the WXG100 family
LLH_RS03390	COG2963	transposase activity
LLH_RS03395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LLH_RS03415	COG4152	abc transporter atp-binding protein
LLH_RS03450	COG0658	competence protein
LLH_RS03450	COG2333	competence protein COMEC
LLH_RS03465	COG0356	it plays a direct role in the translocation of protons across the membrane
LLH_RS03470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LLH_RS03480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LLH_RS03510	COG2963	transposase activity
LLH_RS03515	COG2801	Transposase and inactivated derivatives
LLH_RS03530	COG1126	abc transporter atp-binding protein
LLH_RS03535	COG0765	amino acid transport
LLH_RS03560	COG4493	Belongs to the UPF0637 family
LLH_RS03580	COG1136	(ABC) transporter
LLH_RS03585	COG2963	transposase activity
LLH_RS03590	COG2801	Transposase and inactivated derivatives
LLH_RS03595	COG2963	transposase activity
LLH_RS03600	COG2801	Transposase and inactivated derivatives
LLH_RS03605	COG0745	RESPONSE REGULATOR receiver
LLH_RS03610	COG5002	protein histidine kinase activity
LLH_RS03615	COG0287	Prephenate dehydrogenase
LLH_RS03630	COG0077	Prephenate dehydratase
LLH_RS03640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LLH_RS03645	COG0268	Binds directly to 16S ribosomal RNA
LLH_RS03655	COG1597	lipid kinase activity
LLH_RS03660	COG0670	Belongs to the BI1 family
LLH_RS03665	COG1556	Lactate utilization protein
LLH_RS03670	COG1139	Iron-sulfur cluster binding protein
LLH_RS03675	COG0247	lactate metabolic process
LLH_RS03680	COG0561	phosphatase activity
LLH_RS03685	COG2252	PERMEase
LLH_RS03710	COG4122	O-methyltransferase activity
LLH_RS03715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LLH_RS03740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LLH_RS03755	COG0573	inorganic phosphate transmembrane transporter activity
LLH_RS03760	COG0581	inorganic phosphate transmembrane transporter activity
LLH_RS03765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LLH_RS03770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LLH_RS03775	COG0704	Plays a role in the regulation of phosphate uptake
LLH_RS03785	COG1619	proteins homologs of microcin C7 resistance protein MccF
LLH_RS03795	COG2801	Transposase and inactivated derivatives
LLH_RS03805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LLH_RS03825	COG3716	PTS system mannose fructose sorbose family IID component
LLH_RS03830	COG3715	PTS system
LLH_RS03880	COG3833	ABC-type maltose transport systems, permease component
LLH_RS03885	COG1175	transmembrane transport
LLH_RS03895	COG0366	Alpha amylase catalytic
LLH_RS03900	COG0366	Alpha amylase catalytic
LLH_RS03905	COG0110	maltose O-acetyltransferase activity
LLH_RS03915	COG0366	Alpha amylase catalytic
LLH_RS03925	COG1609	Transcriptional regulator
LLH_RS03930	COG0745	RESPONSE REGULATOR receiver
LLH_RS03935	COG5002	protein histidine kinase activity
LLH_RS03940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LLH_RS03950	COG2723	6-phospho-beta-galactosidase activity
LLH_RS04000	COG0741	lytic transglycosylase activity
LLH_RS04010	COG0673	inositol 2-dehydrogenase activity
LLH_RS04015	COG0572	uridine kinase
LLH_RS04020	COG0280	phosphate acetyltransferase
LLH_RS04030	COG0561	phosphatase activity
LLH_RS04035	COG1674	ftsk spoiiie
LLH_RS04045	COG1466	dna polymerase III delta subunit
LLH_RS04050	COG3599	regulation of cell shape
LLH_RS04060	COG0116	Belongs to the methyltransferase superfamily
LLH_RS04070	COG0006	proline dipeptidase activity
LLH_RS04075	COG1609	Transcriptional regulator
LLH_RS04085	COG1286	toxin biosynthetic process
LLH_RS04095	COG3118	belongs to the thioredoxin family
LLH_RS04115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LLH_RS04120	COG1609	Transcriptional regulator
LLH_RS04125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LLH_RS04145	COG1879	ABC-type sugar transport system periplasmic component
LLH_RS04175	COG0477	Major facilitator Superfamily
LLH_RS04180	COG1802	Transcriptional regulator
LLH_RS04185	COG0246	Mannitol dehydrogenase
LLH_RS04190	COG1312	Catalyzes the dehydration of D-mannonate
LLH_RS04210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LLH_RS04215	COG0800	Aldolase
LLH_RS04220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LLH_RS04250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LLH_RS04265	COG1285	pathogenesis
LLH_RS04280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LLH_RS04330	COG1230	cation diffusion facilitator family transporter
LLH_RS04360	COG0505	Belongs to the CarA family
LLH_RS04370	COG2801	Transposase and inactivated derivatives
LLH_RS04380	COG2801	Transposase and inactivated derivatives
LLH_RS04390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LLH_RS04395	COG1408	metallophosphoesterase
LLH_RS04410	COG0254	rRNA binding
LLH_RS04420	COG0745	RESPONSE REGULATOR receiver
LLH_RS04425	COG5002	protein histidine kinase activity
LLH_RS04430	COG0004	ammonium transporteR
LLH_RS04435	COG0347	Belongs to the P(II) protein family
LLH_RS04440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LLH_RS04445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LLH_RS04455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LLH_RS04515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LLH_RS04525	COG0363	glucosamine-6-phosphate deaminase activity
LLH_RS04530	COG3425	synthase
LLH_RS04535	COG0183	Belongs to the thiolase family
LLH_RS04545	COG0228	four-way junction DNA binding
LLH_RS04550	COG1837	Belongs to the UPF0109 family
LLH_RS04570	COG0336	Belongs to the RNA methyltransferase TrmD family
LLH_RS04580	COG1307	EDD domain protein, DegV family
LLH_RS04585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LLH_RS04595	COG0617	tRNA 3'-terminal CCA addition
LLH_RS04600	COG4690	dipeptidase activity
LLH_RS04620	COG0488	(ABC) transporter
LLH_RS04630	COG0673	inositol 2-dehydrogenase activity
LLH_RS04635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LLH_RS04640	COG0167	dihydroorotate dehydrogenase activity
LLH_RS04655	COG1063	alcohol dehydrogenase
LLH_RS04665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LLH_RS04670	COG0698	ribose 5-phosphate isomerase
LLH_RS04675	COG2723	6-phospho-beta-galactosidase activity
LLH_RS04710	COG1846	Transcriptional regulator
LLH_RS04715	COG0477	Major facilitator Superfamily
LLH_RS04720	COG4221	oxidoreductase activity
LLH_RS04730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LLH_RS04760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LLH_RS04790	COG0542	response to heat
LLH_RS04795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LLH_RS04800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LLH_RS04805	COG1132	(ABC) transporter
LLH_RS04830	COG0138	bifunctional purine biosynthesis protein purh
LLH_RS04835	COG1011	Hydrolase
LLH_RS04850	COG0151	Belongs to the GarS family
LLH_RS04855	COG0561	phosphatase activity
LLH_RS04860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LLH_RS04875	COG2115	Belongs to the xylose isomerase family
LLH_RS04885	COG1070	Carbohydrate kinase
LLH_RS04895	COG2211	Major facilitator Superfamily
LLH_RS04950	COG0454	-acetyltransferase
LLH_RS04955	COG0582	viral genome integration into host DNA
LLH_RS04970	COG2963	transposase activity
LLH_RS04975	COG2801	Transposase and inactivated derivatives
LLH_RS04990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LLH_RS04995	COG0842	Transport permease protein
LLH_RS05000	COG1131	(ABC) transporter
LLH_RS05030	COG2963	transposase activity
LLH_RS05035	COG2801	Transposase and inactivated derivatives
LLH_RS05060	COG2723	6-phospho-beta-galactosidase activity
LLH_RS05075	COG0519	Catalyzes the synthesis of GMP from XMP
LLH_RS05075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LLH_RS05080	COG4209	transmembrane transport
LLH_RS05085	COG0395	ABC-type sugar transport system, permease component
LLH_RS05125	COG2963	transposase activity
LLH_RS05130	COG2801	Transposase and inactivated derivatives
LLH_RS05135	COG1846	Transcriptional regulator
LLH_RS05140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LLH_RS05145	COG3328	transposase activity
LLH_RS05155	COG2801	Transposase and inactivated derivatives
LLH_RS05160	COG2801	Transposase and inactivated derivatives
LLH_RS05170	COG4221	oxidoreductase activity
LLH_RS05190	COG0735	belongs to the Fur family
LLH_RS05215	COG0778	Nitroreductase
LLH_RS05220	COG3759	membrane
LLH_RS05230	COG0512	Glutamine amidotransferase of anthranilate synthase
LLH_RS05235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LLH_RS05255	COG0134	indole-3-glycerol-phosphate synthase activity
LLH_RS05260	COG0135	phosphoribosylanthranilate isomerase activity
LLH_RS05280	COG3711	transcriptional antiterminator
LLH_RS05285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LLH_RS05285	COG1263	PTS System
LLH_RS05285	COG2190	(PTS) system
LLH_RS05290	COG2723	6-phospho-beta-galactosidase activity
LLH_RS05300	COG3448	diguanylate cyclase activity
LLH_RS05300	COG4175	Glycine betaine
LLH_RS05320	COG3969	phosphoadenosine phosphosulfate
LLH_RS05325	COG1475	DNA binding
LLH_RS05340	COG3223	Belongs to the PsiE family
LLH_RS05345	COG1072	(Pantothenic acid kinase))
LLH_RS05350	COG2813	Specifically methylates the guanine in position
LLH_RS05365	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LLH_RS05375	COG1744	ABC transporter substrate-binding protein PnrA-like
LLH_RS05380	COG2188	Transcriptional regulator
LLH_RS05395	COG0745	RESPONSE REGULATOR receiver
LLH_RS05400	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LLH_RS05420	COG2801	Transposase and inactivated derivatives
LLH_RS05425	COG2801	Transposase and inactivated derivatives
LLH_RS05455	COG3328	transposase activity
LLH_RS05460	COG2963	transposase activity
LLH_RS05465	COG2801	Transposase and inactivated derivatives
LLH_RS05485	COG0564	pseudouridine synthase activity
LLH_RS05490	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LLH_RS05500	COG0463	Glycosyl transferase, family 2
LLH_RS05505	COG0745	RESPONSE REGULATOR receiver
LLH_RS05515	COG5002	protein histidine kinase activity
LLH_RS05520	COG0671	phosphoesterase, PA-phosphatase related
LLH_RS05525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LLH_RS05535	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LLH_RS05540	COG1393	Belongs to the ArsC family
LLH_RS05545	COG0488	(ABC) transporter
LLH_RS05555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LLH_RS05570	COG3328	transposase activity
LLH_RS05580	COG2963	transposase activity
LLH_RS05585	COG2801	Transposase and inactivated derivatives
LLH_RS05605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LLH_RS05610	COG2384	SAM-dependent methyltransferase
LLH_RS05615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LLH_RS05630	COG1078	dGTPase activity
LLH_RS05645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LLH_RS05655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LLH_RS05665	COG1702	phosphate starvation-inducible protein PhoH
LLH_RS05675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LLH_RS05680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LLH_RS05705	COG1739	Uncharacterized protein family UPF0029
LLH_RS05745	COG0038	chloride channel
LLH_RS05750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LLH_RS05760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LLH_RS05775	COG1136	(ABC) transporter
LLH_RS05785	COG3442	glutamine amidotransferase
LLH_RS05790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LLH_RS05795	COG3527	Alpha-acetolactate decarboxylase
LLH_RS05805	COG0702	epimerase
LLH_RS05810	COG0531	amino acid
LLH_RS05815	COG2963	transposase activity
LLH_RS05820	COG2801	Transposase and inactivated derivatives
LLH_RS05835	COG3764	Sortase (surface protein transpeptidase)
LLH_RS05855	COG0210	DNA helicase
LLH_RS05865	COG0519	Catalyzes the synthesis of GMP from XMP
LLH_RS05875	COG1053	succinate dehydrogenase
LLH_RS05935	COG0196	riboflavin kinase activity
LLH_RS05940	COG0039	L-malate dehydrogenase activity
LLH_RS05950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LLH_RS05985	COG1475	DNA binding
LLH_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LLH_RS06010	COG0647	UMP catabolic process
LLH_RS06070	COG2233	PERMEase
LLH_RS06080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LLH_RS06090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LLH_RS06115	COG0302	gtp cyclohydrolase
LLH_RS06115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LLH_RS06120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LLH_RS06130	COG0285	dihydrofolate synthase activity
LLH_RS06135	COG1428	Deoxynucleoside kinase
LLH_RS06165	COG1176	ABC-type spermidine putrescine transport system, permease component I
LLH_RS06170	COG1177	transmembrane transport
LLH_RS06185	COG1917	Cupin 2, conserved barrel domain protein
LLH_RS06185	COG2207	Transcriptional regulator
LLH_RS06195	COG3328	transposase activity
LLH_RS06205	COG3507	Belongs to the glycosyl hydrolase 43 family
LLH_RS06210	COG2801	Transposase and inactivated derivatives
LLH_RS06215	COG2963	transposase activity
LLH_RS06225	COG0640	Transcriptional regulator
LLH_RS06270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LLH_RS06275	COG0758	DNA mediated transformation
LLH_RS06280	COG0251	oxidation-reduction process
LLH_RS06285	COG3527	Alpha-acetolactate decarboxylase
LLH_RS06290	COG3328	transposase activity
LLH_RS06295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LLH_RS06305	COG0440	acetolactate synthase activity
LLH_RS06310	COG0028	Belongs to the TPP enzyme family
LLH_RS06320	COG1119	ATPase activity
LLH_RS06325	COG0066	3-isopropylmalate dehydratase activity
LLH_RS06350	COG0473	3-isopropylmalate dehydrogenase activity
LLH_RS06370	COG1054	Belongs to the UPF0176 family
LLH_RS06375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LLH_RS06380	COG0140	phosphoribosyl-ATP diphosphatase activity
LLH_RS06380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LLH_RS06395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LLH_RS06400	COG3231	kanamycin kinase activity
LLH_RS06480	COG1733	regulation of RNA biosynthetic process
LLH_RS06485	COG2814	Major facilitator Superfamily
LLH_RS06490	COG0028	Belongs to the TPP enzyme family
LLH_RS06500	COG0628	permease
LLH_RS06505	COG2226	methyltransferase
LLH_RS06510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LLH_RS06515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LLH_RS06530	COG2801	Transposase and inactivated derivatives
LLH_RS06535	COG2963	transposase activity
LLH_RS06540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LLH_RS06550	COG0656	L-ascorbic acid biosynthetic process
LLH_RS06560	COG1393	Belongs to the ArsC family
LLH_RS06565	COG2963	transposase activity
LLH_RS06570	COG2801	Transposase and inactivated derivatives
LLH_RS06595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LLH_RS06600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LLH_RS06605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LLH_RS06610	COG1696	Membrane protein involved in D-alanine export
LLH_RS06615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LLH_RS06625	COG0351	phosphomethylpyrimidine kinase
LLH_RS06645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LLH_RS06655	COG2814	Major facilitator Superfamily
LLH_RS06660	COG1846	Transcriptional regulator
LLH_RS06665	COG0222	ribosome binding
LLH_RS06670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LLH_RS06685	COG3620	sequence-specific DNA binding
LLH_RS06690	COG1132	(ABC) transporter
LLH_RS06720	COG1187	pseudouridine synthase activity
LLH_RS06725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LLH_RS06735	COG4974	Belongs to the 'phage' integrase family
LLH_RS06750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LLH_RS06760	COG3763	UPF0154 protein
LLH_RS06770	COG0493	'glutamate synthase
LLH_RS06775	COG0067	glutamate synthase
LLH_RS06775	COG0070	glutamate synthase
LLH_RS06775	COG0069	glutamate synthase activity
LLH_RS06780	COG0110	maltose O-acetyltransferase activity
LLH_RS06785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LLH_RS06790	COG0668	transmembrane transport
LLH_RS06800	COG0531	amino acid
LLH_RS06815	COG2801	Transposase and inactivated derivatives
LLH_RS06820	COG2963	transposase activity
LLH_RS06855	COG0803	Belongs to the bacterial solute-binding protein 9 family
LLH_RS06865	COG3328	transposase activity
LLH_RS06890	COG0419	ATPase involved in DNA repair
LLH_RS06895	COG0420	3'-5' exonuclease activity
LLH_RS06900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LLH_RS06905	COG1393	Belongs to the ArsC family
LLH_RS06920	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LLH_RS06925	COG2226	methyltransferase
LLH_RS06930	COG3845	ABC transporter
LLH_RS06935	COG4603	Belongs to the binding-protein-dependent transport system permease family
LLH_RS06940	COG1079	Belongs to the binding-protein-dependent transport system permease family
LLH_RS06945	COG0039	L-malate dehydrogenase activity
LLH_RS06950	COG0469	pyruvate kinase activity
LLH_RS06955	COG0205	6-phosphofructokinase activity
LLH_RS06970	COG3853	Toxic anion resistance protein (TelA)
LLH_RS07000	COG0142	geranyltranstransferase activity
LLH_RS07020	COG0167	dihydroorotate dehydrogenase activity
LLH_RS07030	COG2814	Major facilitator Superfamily
LLH_RS07035	COG2188	Transcriptional regulator
LLH_RS07040	COG2723	6-phospho-beta-galactosidase activity
LLH_RS07060	COG1175	transmembrane transport
LLH_RS07100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LLH_RS07105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LLH_RS07135	COG2801	Transposase and inactivated derivatives
LLH_RS07145	COG2801	Transposase and inactivated derivatives
LLH_RS07160	COG2801	Transposase and inactivated derivatives
LLH_RS07165	COG2963	transposase activity
LLH_RS07190	COG0386	Belongs to the glutathione peroxidase family
LLH_RS07200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LLH_RS07215	COG2801	Transposase and inactivated derivatives
LLH_RS07220	COG2963	transposase activity
LLH_RS07225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LLH_RS07230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LLH_RS07230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LLH_RS07255	COG2153	protein acetylation
LLH_RS07260	COG2176	DNA-directed DNA polymerase activity
LLH_RS07270	COG0187	DNA topoisomerase II activity
LLH_RS07280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LLH_RS07290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LLH_RS07295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LLH_RS07300	COG2177	Part of the ABC transporter FtsEX involved in
LLH_RS07305	COG2884	Cell division ATP-binding protein ftsE
LLH_RS07325	COG2116	formate transmembrane transporter activity
LLH_RS07330	COG3328	transposase activity
LLH_RS07340	COG2801	Transposase and inactivated derivatives
LLH_RS07345	COG2801	Transposase and inactivated derivatives
LLH_RS07360	COG1131	(ABC) transporter
LLH_RS07370	COG1481	regulation of sporulation
LLH_RS07375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LLH_RS07385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LLH_RS07430	COG1396	sequence-specific DNA binding
LLH_RS07440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LLH_RS07450	COG5617	Psort location CytoplasmicMembrane, score
LLH_RS07460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LLH_RS07480	COG0588	phosphoglycerate mutase activity
LLH_RS07495	COG3830	Belongs to the UPF0237 family
LLH_RS07515	COG0557	exoribonuclease II activity
LLH_RS07525	COG0492	ferredoxin-NADP+ reductase activity
LLH_RS07535	COG1126	abc transporter atp-binding protein
LLH_RS07540	COG0765	amino acid transport
LLH_RS07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LLH_RS07560	COG0393	Putative heavy-metal-binding
LLH_RS07580	COG0813	purine-nucleoside phosphorylase activity
LLH_RS07595	COG1316	TRANSCRIPTIONal
LLH_RS07615	COG1442	glycosyl transferase family 8
LLH_RS07625	COG2963	transposase activity
LLH_RS07630	COG1682	transport, permease protein
LLH_RS07635	COG1388	LysM domain
LLH_RS07635	COG1134	teichoic acid transport
LLH_RS07665	COG2814	Major facilitator Superfamily
LLH_RS07690	COG0187	DNA topoisomerase II activity
LLH_RS07700	COG2514	catechol 2,3-dioxygenase activity
LLH_RS07730	COG0488	(ABC) transporter
LLH_RS07745	COG0772	Belongs to the SEDS family
LLH_RS07755	COG0539	negative regulation of cytoplasmic translation
LLH_RS07770	COG2197	response regulator
LLH_RS07775	COG4585	Histidine kinase
LLH_RS07790	COG3328	transposase activity
LLH_RS07795	COG2151	metal-sulfur cluster biosynthetic enzyme
LLH_RS07800	COG1511	domain protein
LLH_RS07810	COG1511	domain protein
LLH_RS07825	COG0589	response to stress
LLH_RS07845	COG1215	transferase activity, transferring glycosyl groups
LLH_RS07860	COG4319	ketosteroid isomerase
LLH_RS07865	COG0335	large ribosomal subunit rRNA binding
LLH_RS07880	COG3328	transposase activity
LLH_RS07885	COG0583	DNA-binding transcription factor activity
LLH_RS07890	COG1136	(ABC) transporter
LLH_RS07905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LLH_RS07910	COG0768	penicillin binding
LLH_RS07920	COG0275	rRNA processing
LLH_RS07945	COG0497	DNA recombination
LLH_RS07950	COG1438	arginine binding
LLH_RS07955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LLH_RS07970	COG1929	Belongs to the glycerate kinase type-1 family
LLH_RS07985	COG1570	exodeoxyribonuclease VII activity
LLH_RS07990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LLH_RS08025	COG1174	glycine betaine transport
LLH_RS08035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LLH_RS08050	COG0736	holo-[acyl-carrier-protein] synthase activity
LLH_RS08060	COG3328	transposase activity
LLH_RS08070	COG1194	a g-specific adenine glycosylase
LLH_RS08075	COG0322	excinuclease ABC activity
LLH_RS08080	COG3201	nicotinamide mononucleotide transporter
LLH_RS08090	COG2801	Transposase and inactivated derivatives
LLH_RS08100	COG5002	protein histidine kinase activity
LLH_RS08105	COG0745	RESPONSE REGULATOR receiver
LLH_RS08110	COG3328	transposase activity
LLH_RS08120	COG0539	negative regulation of cytoplasmic translation
LLH_RS08140	COG2217	Heavy metal translocating P-type atpase
LLH_RS08145	COG2608	mercury ion transmembrane transporter activity
LLH_RS08150	COG3682	Transcriptional regulator
LLH_RS08155	COG1760	l-serine dehydratase
LLH_RS08160	COG1760	l-serine dehydratase
LLH_RS08165	COG3328	transposase activity
LLH_RS08170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LLH_RS08175	COG1252	NADH dehydrogenase
LLH_RS08185	COG2801	Transposase and inactivated derivatives
LLH_RS08190	COG2801	Transposase and inactivated derivatives
LLH_RS08210	COG2723	6-phospho-beta-galactosidase activity
LLH_RS08235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LLH_RS08240	COG0552	protein localization to endoplasmic reticulum
LLH_RS08250	COG0561	phosphatase activity
LLH_RS08255	COG1113	amino acid transport
LLH_RS08275	COG1368	sulfuric ester hydrolase activity
LLH_RS08280	COG1196	nuclear chromosome segregation
LLH_RS08305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LLH_RS08310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LLH_RS08315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LLH_RS08325	COG2801	Transposase and inactivated derivatives
LLH_RS08335	COG2801	Transposase and inactivated derivatives
LLH_RS08340	COG2910	NAD(P)H-binding
LLH_RS08345	COG4708	membrane
LLH_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
LLH_RS08370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LLH_RS08370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LLH_RS08375	COG0708	Exodeoxyribonuclease III
LLH_RS08385	COG1349	DNA-binding transcription factor activity
LLH_RS08390	COG1393	Belongs to the ArsC family
LLH_RS08395	COG1937	Protein conserved in bacteria
LLH_RS08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
LLH_RS08410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LLH_RS08440	COG0439	Biotin carboxylase
LLH_RS08455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LLH_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
LLH_RS08465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LLH_RS08470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LLH_RS08485	COG1482	cell wall glycoprotein biosynthetic process
LLH_RS08490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LLH_RS08505	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LLH_RS08510	COG0195	Participates in both transcription termination and antitermination
LLH_RS08525	COG1346	cytolysis
LLH_RS08570	COG1160	GTP binding
LLH_RS08580	COG0778	Nitroreductase
LLH_RS08585	COG1484	DNA-dependent DNA replication
LLH_RS08595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LLH_RS08615	COG0305	Participates in initiation and elongation during chromosome replication
LLH_RS08630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LLH_RS08645	COG0527	aspartate kinase activity
LLH_RS08660	COG0561	phosphatase activity
LLH_RS08665	COG0252	asparaginase activity
LLH_RS08675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LLH_RS08680	COG4109	DRTGG domain
LLH_RS08690	COG1169	isochorismate synthase
LLH_RS08700	COG2267	carboxylic ester hydrolase activity
LLH_RS08705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LLH_RS08710	COG0318	PFAM AMP-dependent synthetase and ligase
LLH_RS08715	COG4948	Mandelate Racemase Muconate Lactonizing
LLH_RS08725	COG1609	Transcriptional regulator
LLH_RS08730	COG1501	Belongs to the glycosyl hydrolase 31 family
LLH_RS08745	COG1653	transport
LLH_RS08750	COG0395	ABC-type sugar transport system, permease component
LLH_RS08755	COG4209	transmembrane transport
LLH_RS08775	COG1234	tRNA 3'-trailer cleavage
LLH_RS08800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LLH_RS08825	COG0586	Pfam SNARE associated Golgi protein
LLH_RS08850	COG1846	Transcriptional regulator
LLH_RS08855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LLH_RS08860	COG4988	ABC transporter
LLH_RS08865	COG1294	oxidase, subunit
LLH_RS08870	COG1271	oxidase subunit
LLH_RS08880	COG3104	oligopeptide transport
LLH_RS08885	COG1266	CAAX protease self-immunity
LLH_RS08900	COG0058	SHG alpha-glucan phosphorylase activity
LLH_RS08910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LLH_RS08920	COG1640	4-alpha-glucanotransferase
LLH_RS08930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LLH_RS08940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LLH_RS08945	COG0006	proline dipeptidase activity
LLH_RS08950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LLH_RS08955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LLH_RS08965	COG0084	hydrolase, TatD family'
LLH_RS08970	COG3592	Divergent 4Fe-4S mono-cluster
LLH_RS08985	COG0726	polysaccharide deacetylase
LLH_RS08995	COG2801	Transposase and inactivated derivatives
LLH_RS09000	COG2963	transposase activity
LLH_RS09015	COG1393	Belongs to the ArsC family
LLH_RS09025	COG0740	serine-type endopeptidase activity
LLH_RS09040	COG0372	Belongs to the citrate synthase family
LLH_RS09050	COG2801	Transposase and inactivated derivatives
LLH_RS09055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LLH_RS09060	COG0772	Belongs to the SEDS family
LLH_RS09065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LLH_RS09070	COG2814	Major facilitator Superfamily
LLH_RS09075	COG0237	dephospho-CoA kinase activity
LLH_RS09085	COG1882	Formate acetyltransferase
LLH_RS09095	COG0318	PFAM AMP-dependent synthetase and ligase
LLH_RS09105	COG0577	efflux transmembrane transporter activity
LLH_RS09115	COG0148	phosphopyruvate hydratase activity
LLH_RS09175	COG4974	Belongs to the 'phage' integrase family
LLH_RS09180	COG0148	phosphopyruvate hydratase activity
LLH_RS09185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LLH_RS09190	COG0542	response to heat
LLH_RS09215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LLH_RS09220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LLH_RS09225	COG3343	RNA polymerase activity
LLH_RS09230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LLH_RS09235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LLH_RS09235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LLH_RS09240	COG0300	oxidoreductase activity
LLH_RS09300	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LLH_RS09315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LLH_RS09320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LLH_RS09345	COG2246	polysaccharide biosynthetic process
LLH_RS09355	COG0024	Methionine aminopeptidase
LLH_RS09380	COG0716	FMN binding
LLH_RS09390	COG0789	Transcriptional regulator
LLH_RS09405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LLH_RS09410	COG1254	Belongs to the acylphosphatase family
LLH_RS09415	COG0560	Phosphoserine phosphatase
LLH_RS09420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LLH_RS09430	COG0741	lytic transglycosylase activity
LLH_RS09440	COG0009	L-threonylcarbamoyladenylate synthase
LLH_RS09450	COG2890	protein-(glutamine-N5) methyltransferase activity
LLH_RS09455	COG0778	Nitroreductase
LLH_RS09475	COG1435	thymidine kinase activity
LLH_RS09530	COG2801	Transposase and inactivated derivatives
LLH_RS09535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LLH_RS09540	COG1942	4-Oxalocrotonate Tautomerase
LLH_RS09550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LLH_RS09555	COG4684	Psort location CytoplasmicMembrane, score
LLH_RS09565	COG0706	membrane insertase activity
LLH_RS09570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LLH_RS09575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LLH_RS09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LLH_RS09595	COG0494	nUDIX hydrolase
LLH_RS09600	COG0242	peptide deformylase activity
LLH_RS09605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LLH_RS09610	COG1959	2 iron, 2 sulfur cluster binding
LLH_RS09615	COG0542	response to heat
LLH_RS09645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LLH_RS09650	COG0358	DNA primase activity
LLH_RS09755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LLH_RS09760	COG0483	inositol monophosphate 1-phosphatase activity
LLH_RS09765	COG4476	Belongs to the UPF0223 family
LLH_RS09770	COG1393	Belongs to the ArsC family
LLH_RS09775	COG4474	Belongs to the UPF0398 family
LLH_RS09795	COG1388	LysM domain
LLH_RS09795	COG1705	Flagellar rod assembly protein muramidase FlgJ
LLH_RS09805	COG4166	transmembrane transport
LLH_RS09810	COG0791	NLP P60 protein
LLH_RS09810	COG3883	PFAM NLP P60 protein
LLH_RS09815	COG1104	cysteine desulfurase activity
LLH_RS09830	COG3328	transposase activity
LLH_RS09835	COG3328	transposase activity
LLH_RS09855	COG2169	Transcriptional regulator
LLH_RS09860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LLH_RS09865	COG0456	acetyltransferase
LLH_RS09870	COG0776	regulation of translation
LLH_RS09880	COG1472	Belongs to the glycosyl hydrolase 3 family
LLH_RS09885	COG2755	lipolytic protein G-D-S-L family
LLH_RS09890	COG1307	EDD domain protein, DegV family
LLH_RS09895	COG1272	protein, Hemolysin III
LLH_RS09900	COG0587	DNA-directed DNA polymerase activity
LLH_RS09915	COG3328	transposase activity
LLH_RS09920	COG1428	Deoxynucleoside kinase
LLH_RS09925	COG1611	Belongs to the LOG family
LLH_RS10010	COG0504	CTP synthase activity
LLH_RS10015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LLH_RS10025	COG4720	Psort location CytoplasmicMembrane, score
LLH_RS10060	COG3328	transposase activity
LLH_RS10205	COG2801	Transposase and inactivated derivatives
LLH_RS10380	COG2261	transglycosylase associated protein
LLH_RS10410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LLH_RS10420	COG0194	GDP metabolic process
LLH_RS10430	COG0363	glucosamine-6-phosphate deaminase activity
LLH_RS10440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LLH_RS10445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LLH_RS10445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LLH_RS10465	COG3942	CHAP domain
LLH_RS10465	COG1705	Flagellar rod assembly protein muramidase FlgJ
LLH_RS10470	COG0191	fructose-bisphosphate aldolase activity
LLH_RS10530	COG2860	membrane
LLH_RS10555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LLH_RS10565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LLH_RS10570	COG0626	cystathionine gamma-synthase activity
LLH_RS10595	COG3481	metal-dependent phosphohydrolase, HD sub domain
LLH_RS10625	COG3584	3D domain protein
LLH_RS10625	COG1388	LysM domain
LLH_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LLH_RS10630	COG0072	phenylalanine-tRNA ligase activity
LLH_RS10640	COG3479	Phenolic acid decarboxylase
LLH_RS10660	COG3397	chitin binding
LLH_RS10725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LLH_RS10735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LLH_RS10740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LLH_RS10745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LLH_RS10755	COG0537	adenosine 5'-monophosphoramidase activity
LLH_RS10785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LLH_RS10790	COG1426	Protein conserved in bacteria
LLH_RS10795	COG0612	Peptidase, M16
LLH_RS10800	COG0612	Peptidase, M16
LLH_RS10805	COG2501	S4 domain
LLH_RS10815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LLH_RS10830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LLH_RS10860	COG0667	Aldo Keto reductase
LLH_RS10875	COG0826	peptidase U32
LLH_RS10890	COG0500	methyltransferase
LLH_RS10900	COG5484	DNA packaging
LLH_RS10900	COG3728	DNA packaging
LLH_RS11005	COG1131	(ABC) transporter
LLH_RS11020	COG0537	adenosine 5'-monophosphoramidase activity
LLH_RS11035	COG0081	regulation of translation
LLH_RS11040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LLH_RS11055	COG4479	Belongs to the UPF0346 family
LLH_RS11060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LLH_RS11065	COG2996	Protein conserved in bacteria
LLH_RS11090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LLH_RS11095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LLH_RS11100	COG0827	DNA restriction-modification system
LLH_RS11110	COG1217	gtp-binding protein TYPA
LLH_RS11115	COG2801	Transposase and inactivated derivatives
LLH_RS11120	COG2963	transposase activity
LLH_RS11150	COG1940	carbohydrate kinase activity
LLH_RS11160	COG0783	Belongs to the Dps family
LLH_RS11180	COG0531	amino acid
LLH_RS11205	COG0531	amino acid
LLH_RS11210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LLH_RS11215	COG2235	arginine
LLH_RS11230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LLH_RS11240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LLH_RS11300	COG2963	transposase activity
LLH_RS11305	COG2801	Transposase and inactivated derivatives
LLH_RS11320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LLH_RS11340	COG3328	transposase activity
LLH_RS11345	COG1266	CAAX protease self-immunity
LLH_RS11360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LLH_RS11365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LLH_RS11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LLH_RS11385	COG1335	isochorismatase
LLH_RS11430	COG4956	integral membrane protein (PIN domain superfamily)
LLH_RS11455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LLH_RS11460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LLH_RS11480	COG1216	Glycosyl transferase, family 2
LLH_RS11485	COG1216	Glycosyl transferase, family 2
LLH_RS11500	COG0203	ribosomal protein L17
LLH_RS11505	COG0202	RNA polymerase activity
LLH_RS11510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LLH_RS11515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LLH_RS11520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LLH_RS11525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LLH_RS11530	COG0563	adenylate kinase activity
LLH_RS11540	COG0200	Binds to the 23S rRNA
LLH_RS11545	COG1841	ribosomal large subunit assembly
LLH_RS11550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LLH_RS11555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LLH_RS11565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LLH_RS11575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LLH_RS11580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LLH_RS11590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LLH_RS11595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LLH_RS11600	COG0255	Belongs to the universal ribosomal protein uL29 family
LLH_RS11605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LLH_RS11610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LLH_RS11615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LLH_RS11620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LLH_RS11625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LLH_RS11640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LLH_RS11645	COG0051	transcription antitermination factor activity, RNA binding
LLH_RS11650	COG1970	mechanosensitive ion channel activity
LLH_RS11660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LLH_RS11665	COG0250	Participates in transcription elongation, termination and antitermination
LLH_RS11675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LLH_RS11680	COG2755	lipolytic protein G-D-S-L family
LLH_RS11680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LLH_RS11685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LLH_RS11690	COG2323	membrane
LLH_RS11705	COG0564	pseudouridine synthase activity
LLH_RS11710	COG2801	Transposase and inactivated derivatives
LLH_RS11720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LLH_RS11725	COG1121	(ABC) transporter
LLH_RS11730	COG0803	Belongs to the bacterial solute-binding protein 9 family
LLH_RS11730	COG3443	Belongs to the bacterial solute-binding protein 9 family
LLH_RS11735	COG1846	Transcriptional regulator
LLH_RS11760	COG4537	Required for transformation and DNA binding
LLH_RS11765	COG1459	type II secretion system
LLH_RS11770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LLH_RS11785	COG2176	DNA-directed DNA polymerase activity
LLH_RS11795	COG0446	pyridine nucleotide-disulphide oxidoreductase
LLH_RS11800	COG0442	prolyl-tRNA aminoacylation
LLH_RS11805	COG0750	zinc metalloprotease
LLH_RS11810	COG4589	Belongs to the CDS family
LLH_RS11815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LLH_RS11820	COG1862	Preprotein translocase
LLH_RS11840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LLH_RS11850	COG0438	transferase activity, transferring glycosyl groups
LLH_RS11865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LLH_RS11875	COG0560	Phosphoserine phosphatase
LLH_RS11880	COG1609	Transcriptional regulator
LLH_RS11915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LLH_RS11925	COG2706	6-phosphogluconolactonase activity
LLH_RS11940	COG2963	transposase activity
LLH_RS11945	COG2801	Transposase and inactivated derivatives
LLH_RS11970	COG0535	radical SAM domain protein
LLH_RS11975	COG3480	Lon protease (S16) C-terminal proteolytic domain
LLH_RS11985	COG0742	ribosomal rna small subunit methyltransferase
LLH_RS11990	COG2814	Major facilitator Superfamily
LLH_RS12030	COG0702	epimerase
LLH_RS12035	COG1733	regulation of RNA biosynthetic process
LLH_RS12045	COG0525	valine-tRNA ligase activity
LLH_RS12080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LLH_RS12130	COG1070	Carbohydrate kinase
LLH_RS12135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LLH_RS12150	COG1408	metallophosphoesterase
LLH_RS12155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LLH_RS12160	COG0629	single-stranded DNA binding
LLH_RS12165	COG0360	Binds together with S18 to 16S ribosomal RNA
LLH_RS12175	COG0833	amino acid
LLH_RS12180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LLH_RS12190	COG1956	GAF domain-containing protein
LLH_RS12195	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LLH_RS12195	COG1605	Chorismate mutase
LLH_RS12335	COG0174	glutamine synthetase
LLH_RS12340	COG0789	Transcriptional regulator
LLH_RS12345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LLH_RS12350	COG3328	transposase activity
LLH_RS12355	COG2255	four-way junction helicase activity
LLH_RS12405	COG0730	response to heat
LLH_RS12415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LLH_RS12420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LLH_RS12435	COG1794	racemase activity, acting on amino acids and derivatives
LLH_RS12445	COG0367	asparagine synthase
LLH_RS12450	COG3883	PFAM NLP P60 protein
LLH_RS12450	COG3942	CHAP domain
LLH_RS12465	COG0494	nUDIX hydrolase
LLH_RS12475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LLH_RS12480	COG2814	Major facilitator Superfamily
LLH_RS12485	COG0589	response to stress
LLH_RS12500	COG1309	transcriptional regulator
LLH_RS12505	COG1187	pseudouridine synthase activity
LLH_RS12540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LLH_RS12545	COG2824	Alkylphosphonate utilization operon protein PhnA
LLH_RS12575	COG1266	CAAX protease self-immunity
LLH_RS12635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LLH_RS12640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LLH_RS12650	COG1136	(ABC) transporter
LLH_RS12660	COG0681	Belongs to the peptidase S26 family
LLH_RS12665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LLH_RS12690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LLH_RS12695	COG0049	tRNA binding
LLH_RS12700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LLH_RS12715	COG1686	Belongs to the peptidase S11 family
LLH_RS12720	COG4975	Glucose uptake
LLH_RS12725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LLH_RS12730	COG1242	4 iron, 4 sulfur cluster binding
LLH_RS12975	COG2801	Transposase and inactivated derivatives
LLH_RS13100	COG0592	DNA-directed DNA polymerase activity
LLH_RS13255	COG3328	transposase activity
LLH_RS13415	COG0438	transferase activity, transferring glycosyl groups
LLH_RS13420	COG3590	peptidase
LLH_RS13445	COG1705	Flagellar rod assembly protein muramidase FlgJ
LLH_RS13445	COG3942	CHAP domain
LLH_RS13460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site