locus-tag	class	description
UC509_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS00010	COG0592	DNA-directed DNA polymerase activity
UC509_RS00035	COG0012	GTP binding
UC509_RS00055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UC509_RS00060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UC509_RS00080	COG0037	tRNA processing
UC509_RS00085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
UC509_RS00090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UC509_RS00135	COG2213	PTS system mannitol-specific
UC509_RS00155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UC509_RS00180	COG0659	secondary active sulfate transmembrane transporter activity
UC509_RS00185	COG3153	acetyltransferase
UC509_RS00195	COG0436	Aminotransferase
UC509_RS00210	COG0508	dehydrogenase complex catalyzes the overall conversion of
UC509_RS00225	COG0095	Lipoate-protein ligase
UC509_RS00230	COG0584	glycerophosphoryl diester phosphodiesterase
UC509_RS00235	COG1418	mRNA catabolic process
UC509_RS00250	COG0180	Tryptophanyl-tRNA synthetase
UC509_RS00255	COG1764	response to oxidative stress
UC509_RS00275	COG0488	(ABC) transporter
UC509_RS00285	COG4221	oxidoreductase activity
UC509_RS00290	COG1309	transcriptional regulator
UC509_RS00305	COG4221	oxidoreductase activity
UC509_RS00315	COG0582	viral genome integration into host DNA
UC509_RS00385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UC509_RS00390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UC509_RS00395	COG2217	Heavy metal translocating P-type atpase
UC509_RS00405	COG1475	DNA binding
UC509_RS00410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UC509_RS00415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UC509_RS00430	COG0488	(ABC) transporter
UC509_RS00455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UC509_RS00460	COG0726	polysaccharide deacetylase
UC509_RS00485	COG1011	Hydrolase
UC509_RS00490	COG0531	amino acid
UC509_RS00495	COG0204	Acyl-transferase
UC509_RS00505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UC509_RS00510	COG0653	protein targeting
UC509_RS00515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UC509_RS00535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UC509_RS00565	COG2076	Multidrug Resistance protein
UC509_RS00570	COG2814	Major facilitator Superfamily
UC509_RS00575	COG2963	transposase activity
UC509_RS00580	COG2801	Transposase and inactivated derivatives
UC509_RS00630	COG0594	ribonuclease P activity
UC509_RS00635	COG0706	membrane insertase activity
UC509_RS00645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UC509_RS00650	COG4989	oxidoreductase activity
UC509_RS00660	COG1266	CAAX protease self-immunity
UC509_RS00665	COG4472	Bacterial protein of unknown function (DUF965)
UC509_RS00675	COG3906	Belongs to the UPF0473 family
UC509_RS00685	COG0300	oxidoreductase activity
UC509_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
UC509_RS00700	COG1309	transcriptional regulator
UC509_RS00705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UC509_RS00720	COG2963	transposase activity
UC509_RS00725	COG2801	Transposase and inactivated derivatives
UC509_RS00785	COG2814	Major facilitator Superfamily
UC509_RS00790	COG1832	CoA-binding protein
UC509_RS00815	COG0436	Aminotransferase
UC509_RS00820	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UC509_RS00830	COG0154	amidase activity
UC509_RS00855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UC509_RS00870	COG0346	lactoylglutathione lyase activity
UC509_RS00885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UC509_RS00900	COG2723	6-phospho-beta-galactosidase activity
UC509_RS00905	COG0756	dUTP diphosphatase activity
UC509_RS00910	COG0737	Belongs to the 5'-nucleotidase family
UC509_RS00915	COG4470	Protein conserved in bacteria
UC509_RS00920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UC509_RS00930	COG0142	geranyltranstransferase activity
UC509_RS00960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UC509_RS00965	COG1461	Dihydroxyacetone kinase
UC509_RS00975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UC509_RS00985	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UC509_RS01005	COG1088	dTDP-glucose 4,6-dehydratase activity
UC509_RS01025	COG0463	Glycosyl transferase, family 2
UC509_RS01045	COG1216	Glycosyl transferase, family 2
UC509_RS01045	COG1442	glycosyl transferase family 8
UC509_RS01080	COG1442	glycosyl transferase family 8
UC509_RS01080	COG1216	Glycosyl transferase, family 2
UC509_RS01085	COG1442	glycosyl transferase family 8
UC509_RS01085	COG1216	Glycosyl transferase, family 2
UC509_RS01090	COG1442	glycosyl transferase family 8
UC509_RS01090	COG1216	Glycosyl transferase, family 2
UC509_RS01095	COG3475	LICD family
UC509_RS01110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UC509_RS01130	COG0516	GMP reductase activity
UC509_RS01130	COG0517	IMP dehydrogenase activity
UC509_RS01135	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UC509_RS01145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UC509_RS01150	COG1534	Rna-binding protein
UC509_RS01160	COG1713	HD superfamily hydrolase involved in NAD metabolism
UC509_RS01170	COG0799	negative regulation of ribosome biogenesis
UC509_RS01175	COG2226	methyltransferase
UC509_RS01180	COG1323	Belongs to the UPF0348 family
UC509_RS01190	COG0217	transcriptional regulatory protein
UC509_RS01200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UC509_RS01210	COG1309	transcriptional regulator
UC509_RS01220	COG0789	Transcriptional regulator
UC509_RS01225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UC509_RS01235	COG2801	Transposase and inactivated derivatives
UC509_RS01240	COG2963	transposase activity
UC509_RS01245	COG0561	phosphatase activity
UC509_RS01255	COG2376	Dihydroxyacetone kinase
UC509_RS01260	COG1309	transcriptional regulator
UC509_RS01265	COG2376	Dihydroxyacetone kinase
UC509_RS01270	COG1461	Dihydroxyacetone kinase
UC509_RS01275	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
UC509_RS01280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UC509_RS01285	COG4690	dipeptidase activity
UC509_RS01300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UC509_RS01315	COG2081	HI0933 family
UC509_RS01320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UC509_RS01335	COG1132	(ABC) transporter
UC509_RS01345	COG0673	inositol 2-dehydrogenase activity
UC509_RS01350	COG1854	S-ribosylhomocysteine lyase activity
UC509_RS01360	COG0656	L-ascorbic acid biosynthetic process
UC509_RS01385	COG1328	CTP reductase activity
UC509_RS01420	COG1122	ATPase activity
UC509_RS01430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UC509_RS01465	COG0726	polysaccharide deacetylase
UC509_RS01485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UC509_RS01490	COG2183	response to ionizing radiation
UC509_RS01495	COG3091	SprT-like family
UC509_RS01500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UC509_RS01520	COG5503	Protein of unknown function (DUF1447)
UC509_RS01535	COG0456	acetyltransferase
UC509_RS01580	COG3639	organic phosphonate transmembrane transporter activity
UC509_RS01585	COG0737	Belongs to the 5'-nucleotidase family
UC509_RS01605	COG1846	Transcriptional regulator
UC509_RS01610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UC509_RS01620	COG1132	(ABC) transporter
UC509_RS01625	COG1132	(ABC) transporter
UC509_RS01630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UC509_RS01635	COG4443	Transcriptional Coactivator p15 (PC4)
UC509_RS01655	COG1268	BioY protein
UC509_RS01660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UC509_RS01670	COG3859	Proton-coupled thiamine transporter YuaJ
UC509_RS01675	COG1464	Belongs to the NlpA lipoprotein family
UC509_RS01695	COG1464	Belongs to the NlpA lipoprotein family
UC509_RS01705	COG2011	ABC-type metal ion transport system permease component
UC509_RS01730	COG1120	ATPase activity
UC509_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UC509_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UC509_RS01745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UC509_RS01760	COG2814	Major facilitator Superfamily
UC509_RS01765	COG0656	L-ascorbic acid biosynthetic process
UC509_RS01770	COG1733	regulation of RNA biosynthetic process
UC509_RS01775	COG0346	lactoylglutathione lyase activity
UC509_RS01780	COG0588	phosphoglycerate mutase activity
UC509_RS01785	COG0450	alkyl hydroperoxide reductase
UC509_RS01790	COG3634	alkyl hydroperoxide reductase activity
UC509_RS01800	COG0768	penicillin binding
UC509_RS01805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UC509_RS01815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UC509_RS01820	COG4166	transmembrane transport
UC509_RS01825	COG4166	transmembrane transport
UC509_RS01830	COG0601	transmembrane transport
UC509_RS01835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UC509_RS01840	COG0444	Belongs to the ABC transporter superfamily
UC509_RS01845	COG4608	Belongs to the ABC transporter superfamily
UC509_RS01855	COG0513	Belongs to the DEAD box helicase family
UC509_RS01865	COG0367	asparagine synthase
UC509_RS01875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UC509_RS01880	COG1113	amino acid transport
UC509_RS01885	COG1113	amino acid transport
UC509_RS01915	COG2357	RelA SpoT domain protein
UC509_RS01925	COG0564	pseudouridine synthase activity
UC509_RS01935	COG0833	amino acid
UC509_RS01970	COG0583	DNA-binding transcription factor activity
UC509_RS01975	COG0583	DNA-binding transcription factor activity
UC509_RS01980	COG2855	membrane
UC509_RS01990	COG0583	DNA-binding transcription factor activity
UC509_RS02005	COG0301	tRNA thio-modification
UC509_RS02025	COG1764	response to oxidative stress
UC509_RS02030	COG0025	NhaP-type Na H and K H
UC509_RS02045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UC509_RS02050	COG1363	Peptidase, m42
UC509_RS02060	COG3118	belongs to the thioredoxin family
UC509_RS02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC509_RS02070	COG0446	pyridine nucleotide-disulphide oxidoreductase
UC509_RS02090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UC509_RS02095	COG5002	protein histidine kinase activity
UC509_RS02100	COG0745	RESPONSE REGULATOR receiver
UC509_RS02110	COG0470	DNA polymerase III
UC509_RS02115	COG1774	PSP1 C-terminal conserved region
UC509_RS02145	COG1846	Transcriptional regulator
UC509_RS02150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UC509_RS02165	COG1304	FMN binding
UC509_RS02170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UC509_RS02180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UC509_RS02195	COG0513	Belongs to the DEAD box helicase family
UC509_RS02210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UC509_RS02215	COG1447	Phosphotransferase system cellobiose-specific component IIA
UC509_RS02225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UC509_RS02230	COG2723	6-phospho-beta-galactosidase activity
UC509_RS02250	COG1597	lipid kinase activity
UC509_RS02255	COG3842	ATPase activity
UC509_RS02290	COG2190	(PTS) system
UC509_RS02290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UC509_RS02290	COG1263	PTS System
UC509_RS02295	COG1263	PTS System
UC509_RS02295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UC509_RS02300	COG1554	hydrolase, family 65, central catalytic
UC509_RS02305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UC509_RS02320	COG0802	atpase or kinase
UC509_RS02330	COG0582	viral genome integration into host DNA
UC509_RS02440	COG0351	phosphomethylpyrimidine kinase
UC509_RS02445	COG4720	Psort location CytoplasmicMembrane, score
UC509_RS02460	COG0504	CTP synthase activity
UC509_RS02540	COG1611	Belongs to the LOG family
UC509_RS02545	COG1428	Deoxynucleoside kinase
UC509_RS02560	COG0587	DNA-directed DNA polymerase activity
UC509_RS02565	COG1272	protein, Hemolysin III
UC509_RS02570	COG1307	EDD domain protein, DegV family
UC509_RS02575	COG2755	lipolytic protein G-D-S-L family
UC509_RS02580	COG1472	Belongs to the glycosyl hydrolase 3 family
UC509_RS02590	COG0776	regulation of translation
UC509_RS02595	COG0456	acetyltransferase
UC509_RS02600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UC509_RS02605	COG2169	Transcriptional regulator
UC509_RS02650	COG1104	cysteine desulfurase activity
UC509_RS02655	COG3883	PFAM NLP P60 protein
UC509_RS02655	COG0791	NLP P60 protein
UC509_RS02660	COG4166	transmembrane transport
UC509_RS02670	COG1705	Flagellar rod assembly protein muramidase FlgJ
UC509_RS02670	COG1388	LysM domain
UC509_RS02690	COG4474	Belongs to the UPF0398 family
UC509_RS02695	COG1393	Belongs to the ArsC family
UC509_RS02700	COG4476	Belongs to the UPF0223 family
UC509_RS02705	COG0483	inositol monophosphate 1-phosphatase activity
UC509_RS02710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UC509_RS02725	COG2801	Transposase and inactivated derivatives
UC509_RS02730	COG2801	Transposase and inactivated derivatives
UC509_RS02835	COG0358	DNA primase activity
UC509_RS02840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UC509_RS02870	COG0542	response to heat
UC509_RS02875	COG1959	2 iron, 2 sulfur cluster binding
UC509_RS02885	COG0242	peptide deformylase activity
UC509_RS02890	COG0494	nUDIX hydrolase
UC509_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UC509_RS02905	COG2801	Transposase and inactivated derivatives
UC509_RS02925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UC509_RS02930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UC509_RS02935	COG0706	membrane insertase activity
UC509_RS02945	COG4684	Psort location CytoplasmicMembrane, score
UC509_RS02950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UC509_RS02960	COG1942	4-Oxalocrotonate Tautomerase
UC509_RS02975	COG2963	transposase activity
UC509_RS02980	COG2801	Transposase and inactivated derivatives
UC509_RS03025	COG1435	thymidine kinase activity
UC509_RS03045	COG0778	Nitroreductase
UC509_RS03050	COG2890	protein-(glutamine-N5) methyltransferase activity
UC509_RS03060	COG0009	L-threonylcarbamoyladenylate synthase
UC509_RS03070	COG0741	lytic transglycosylase activity
UC509_RS03080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UC509_RS03085	COG0560	Phosphoserine phosphatase
UC509_RS03095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UC509_RS03110	COG0789	Transcriptional regulator
UC509_RS03120	COG0716	FMN binding
UC509_RS03135	COG0024	Methionine aminopeptidase
UC509_RS03145	COG2246	polysaccharide biosynthetic process
UC509_RS03170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
UC509_RS03175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UC509_RS03185	COG4980	gas vesicle protein
UC509_RS03190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UC509_RS03250	COG0300	oxidoreductase activity
UC509_RS03255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
UC509_RS03255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UC509_RS03260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UC509_RS03270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UC509_RS03275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UC509_RS03285	COG2801	Transposase and inactivated derivatives
UC509_RS03290	COG2801	Transposase and inactivated derivatives
UC509_RS03305	COG0542	response to heat
UC509_RS03310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UC509_RS03315	COG0148	phosphopyruvate hydratase activity
UC509_RS03325	COG0577	efflux transmembrane transporter activity
UC509_RS03335	COG0318	PFAM AMP-dependent synthetase and ligase
UC509_RS03345	COG1882	Formate acetyltransferase
UC509_RS03350	COG0237	dephospho-CoA kinase activity
UC509_RS03355	COG2814	Major facilitator Superfamily
UC509_RS03360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UC509_RS03365	COG0772	Belongs to the SEDS family
UC509_RS03370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UC509_RS03380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UC509_RS03390	COG0740	serine-type endopeptidase activity
UC509_RS03400	COG1393	Belongs to the ArsC family
UC509_RS03415	COG2963	transposase activity
UC509_RS03435	COG0726	polysaccharide deacetylase
UC509_RS03440	COG1114	Component of the transport system for branched-chain amino acids
UC509_RS03450	COG3592	Divergent 4Fe-4S mono-cluster
UC509_RS03455	COG0084	hydrolase, TatD family'
UC509_RS03465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UC509_RS03470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UC509_RS03475	COG0006	proline dipeptidase activity
UC509_RS03480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UC509_RS03490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UC509_RS03505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UC509_RS03510	COG0297	glycogen (starch) synthase activity
UC509_RS03530	COG1266	CAAX protease self-immunity
UC509_RS03535	COG3104	oligopeptide transport
UC509_RS03545	COG1271	oxidase subunit
UC509_RS03550	COG1294	oxidase, subunit
UC509_RS03555	COG4988	ABC transporter
UC509_RS03560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UC509_RS03565	COG1846	Transcriptional regulator
UC509_RS03590	COG0586	Pfam SNARE associated Golgi protein
UC509_RS03615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UC509_RS03640	COG1234	tRNA 3'-trailer cleavage
UC509_RS03665	COG0395	ABC-type sugar transport system, permease component
UC509_RS03670	COG1653	transport
UC509_RS03685	COG1501	Belongs to the glycosyl hydrolase 31 family
UC509_RS03690	COG1609	Transcriptional regulator
UC509_RS03700	COG4948	Mandelate Racemase Muconate Lactonizing
UC509_RS03705	COG0318	PFAM AMP-dependent synthetase and ligase
UC509_RS03710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UC509_RS03715	COG2267	carboxylic ester hydrolase activity
UC509_RS03725	COG1169	isochorismate synthase
UC509_RS03735	COG4109	DRTGG domain
UC509_RS03740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UC509_RS03750	COG0252	asparaginase activity
UC509_RS03765	COG2268	Band 7 protein
UC509_RS03770	COG0527	aspartate kinase activity
UC509_RS03785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UC509_RS03800	COG0305	Participates in initiation and elongation during chromosome replication
UC509_RS03820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UC509_RS03830	COG1484	DNA-dependent DNA replication
UC509_RS03835	COG0778	Nitroreductase
UC509_RS03845	COG1160	GTP binding
UC509_RS03890	COG1346	cytolysis
UC509_RS03905	COG0195	Participates in both transcription termination and antitermination
UC509_RS03910	COG2740	Nucleic-acid-binding protein implicated in transcription termination
UC509_RS03925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UC509_RS03930	COG1482	cell wall glycoprotein biosynthetic process
UC509_RS03945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UC509_RS03950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UC509_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
UC509_RS03960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UC509_RS03975	COG0439	Biotin carboxylase
UC509_RS04005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UC509_RS04015	COG0446	pyridine nucleotide-disulphide oxidoreductase
UC509_RS04020	COG1937	Protein conserved in bacteria
UC509_RS04025	COG1393	Belongs to the ArsC family
UC509_RS04030	COG1349	DNA-binding transcription factor activity
UC509_RS04040	COG0708	Exodeoxyribonuclease III
UC509_RS04045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC509_RS04045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC509_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
UC509_RS04060	COG4708	membrane
UC509_RS04075	COG2801	Transposase and inactivated derivatives
UC509_RS04085	COG2801	Transposase and inactivated derivatives
UC509_RS04090	COG2801	Transposase and inactivated derivatives
UC509_RS04100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UC509_RS04105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UC509_RS04110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UC509_RS04135	COG1196	nuclear chromosome segregation
UC509_RS04140	COG1368	sulfuric ester hydrolase activity
UC509_RS04160	COG1113	amino acid transport
UC509_RS04165	COG0561	phosphatase activity
UC509_RS04175	COG0552	protein localization to endoplasmic reticulum
UC509_RS04180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UC509_RS04200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UC509_RS04205	COG2723	6-phospho-beta-galactosidase activity
UC509_RS04225	COG2801	Transposase and inactivated derivatives
UC509_RS04230	COG1252	NADH dehydrogenase
UC509_RS04235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UC509_RS04240	COG1760	l-serine dehydratase
UC509_RS04245	COG1760	l-serine dehydratase
UC509_RS04250	COG3682	Transcriptional regulator
UC509_RS04255	COG2608	mercury ion transmembrane transporter activity
UC509_RS04260	COG2217	Heavy metal translocating P-type atpase
UC509_RS04280	COG0539	negative regulation of cytoplasmic translation
UC509_RS04290	COG0745	RESPONSE REGULATOR receiver
UC509_RS04295	COG5002	protein histidine kinase activity
UC509_RS04305	COG3201	nicotinamide mononucleotide transporter
UC509_RS04310	COG0322	excinuclease ABC activity
UC509_RS04315	COG1194	a g-specific adenine glycosylase
UC509_RS04325	COG0653	protein targeting
UC509_RS04350	COG2963	transposase activity
UC509_RS04355	COG2801	Transposase and inactivated derivatives
UC509_RS04370	COG0736	holo-[acyl-carrier-protein] synthase activity
UC509_RS04385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UC509_RS04395	COG1174	glycine betaine transport
UC509_RS04430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UC509_RS04435	COG1570	exodeoxyribonuclease VII activity
UC509_RS04450	COG1929	Belongs to the glycerate kinase type-1 family
UC509_RS04465	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UC509_RS04470	COG1438	arginine binding
UC509_RS04475	COG0497	DNA recombination
UC509_RS04500	COG0275	rRNA processing
UC509_RS04510	COG0768	penicillin binding
UC509_RS04515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UC509_RS04530	COG1136	(ABC) transporter
UC509_RS04535	COG0583	DNA-binding transcription factor activity
UC509_RS04545	COG2357	RelA SpoT domain protein
UC509_RS04550	COG0335	large ribosomal subunit rRNA binding
UC509_RS04570	COG1215	transferase activity, transferring glycosyl groups
UC509_RS04590	COG0589	response to stress
UC509_RS04605	COG1511	domain protein
UC509_RS04615	COG1511	domain protein
UC509_RS04620	COG2151	metal-sulfur cluster biosynthetic enzyme
UC509_RS04625	COG4974	Belongs to the 'phage' integrase family
UC509_RS04635	COG2963	transposase activity
UC509_RS04640	COG2801	Transposase and inactivated derivatives
UC509_RS04660	COG4585	Histidine kinase
UC509_RS04665	COG2197	response regulator
UC509_RS04680	COG0539	negative regulation of cytoplasmic translation
UC509_RS04690	COG0772	Belongs to the SEDS family
UC509_RS04705	COG0488	(ABC) transporter
UC509_RS04710	COG0281	malic enzyme
UC509_RS04745	COG0187	DNA topoisomerase II activity
UC509_RS04775	COG2814	Major facilitator Superfamily
UC509_RS04795	COG2801	Transposase and inactivated derivatives
UC509_RS04800	COG2963	transposase activity
UC509_RS04805	COG1442	glycosyl transferase family 8
UC509_RS04825	COG1316	TRANSCRIPTIONal
UC509_RS04840	COG0813	purine-nucleoside phosphorylase activity
UC509_RS04855	COG0393	Putative heavy-metal-binding
UC509_RS04875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UC509_RS04880	COG0765	amino acid transport
UC509_RS04885	COG1126	abc transporter atp-binding protein
UC509_RS04895	COG0492	ferredoxin-NADP+ reductase activity
UC509_RS04905	COG0557	exoribonuclease II activity
UC509_RS04935	COG3830	Belongs to the UPF0237 family
UC509_RS04950	COG0588	phosphoglycerate mutase activity
UC509_RS04970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UC509_RS04980	COG5617	Psort location CytoplasmicMembrane, score
UC509_RS04990	COG1473	amidohydrolase
UC509_RS05000	COG1105	Belongs to the carbohydrate kinase PfkB family
UC509_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UC509_RS05005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UC509_RS05005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UC509_RS05010	COG2801	Transposase and inactivated derivatives
UC509_RS05055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UC509_RS05060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UC509_RS05070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UC509_RS05075	COG1481	regulation of sporulation
UC509_RS05085	COG1131	(ABC) transporter
UC509_RS05120	COG2884	Cell division ATP-binding protein ftsE
UC509_RS05125	COG2177	Part of the ABC transporter FtsEX involved in
UC509_RS05130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UC509_RS05135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UC509_RS05145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
UC509_RS05155	COG0187	DNA topoisomerase II activity
UC509_RS05165	COG2176	DNA-directed DNA polymerase activity
UC509_RS05170	COG2153	protein acetylation
UC509_RS05205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UC509_RS05205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UC509_RS05210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UC509_RS05215	COG2963	transposase activity
UC509_RS05220	COG2801	Transposase and inactivated derivatives
UC509_RS05240	COG0564	pseudouridine synthase activity
UC509_RS05255	COG0463	Glycosyl transferase, family 2
UC509_RS05260	COG0745	RESPONSE REGULATOR receiver
UC509_RS05270	COG5002	protein histidine kinase activity
UC509_RS05275	COG0671	phosphoesterase, PA-phosphatase related
UC509_RS05280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UC509_RS05290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UC509_RS05295	COG1393	Belongs to the ArsC family
UC509_RS05300	COG0488	(ABC) transporter
UC509_RS05310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UC509_RS05335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UC509_RS05340	COG2384	SAM-dependent methyltransferase
UC509_RS05345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UC509_RS05360	COG1078	dGTPase activity
UC509_RS05375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UC509_RS05385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UC509_RS05395	COG1702	phosphate starvation-inducible protein PhoH
UC509_RS05405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UC509_RS05410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UC509_RS05430	COG1739	Uncharacterized protein family UPF0029
UC509_RS05445	COG0737	Belongs to the 5'-nucleotidase family
UC509_RS05470	COG0038	chloride channel
UC509_RS05475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UC509_RS05485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UC509_RS05500	COG1136	(ABC) transporter
UC509_RS05510	COG3442	glutamine amidotransferase
UC509_RS05515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UC509_RS05520	COG3527	Alpha-acetolactate decarboxylase
UC509_RS05530	COG0702	epimerase
UC509_RS05535	COG0531	amino acid
UC509_RS05540	COG2963	transposase activity
UC509_RS05545	COG2801	Transposase and inactivated derivatives
UC509_RS05570	COG3764	Sortase (surface protein transpeptidase)
UC509_RS05590	COG0210	DNA helicase
UC509_RS05600	COG0519	Catalyzes the synthesis of GMP from XMP
UC509_RS05610	COG1053	succinate dehydrogenase
UC509_RS05670	COG0196	riboflavin kinase activity
UC509_RS05675	COG0039	L-malate dehydrogenase activity
UC509_RS05685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UC509_RS05690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UC509_RS05690	COG1263	PTS System
UC509_RS05695	COG1737	Transcriptional regulator
UC509_RS05725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UC509_RS05745	COG0647	UMP catabolic process
UC509_RS05790	COG2233	PERMEase
UC509_RS05800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UC509_RS05810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UC509_RS05835	COG0302	gtp cyclohydrolase
UC509_RS05835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UC509_RS05840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UC509_RS05850	COG0285	dihydrofolate synthase activity
UC509_RS05885	COG1176	ABC-type spermidine putrescine transport system, permease component I
UC509_RS05890	COG1177	transmembrane transport
UC509_RS05920	COG3507	Belongs to the glycosyl hydrolase 43 family
UC509_RS05945	COG1393	Belongs to the ArsC family
UC509_RS05955	COG0656	L-ascorbic acid biosynthetic process
UC509_RS05965	COG2801	Transposase and inactivated derivatives
UC509_RS05970	COG2963	transposase activity
UC509_RS05985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UC509_RS05990	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
UC509_RS05995	COG2226	methyltransferase
UC509_RS06000	COG0628	permease
UC509_RS06010	COG0028	Belongs to the TPP enzyme family
UC509_RS06015	COG2814	Major facilitator Superfamily
UC509_RS06020	COG1733	regulation of RNA biosynthetic process
UC509_RS06035	COG0557	exoribonuclease II activity
UC509_RS06080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UC509_RS06090	COG3231	kanamycin kinase activity
UC509_RS06095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UC509_RS06110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UC509_RS06110	COG0140	phosphoribosyl-ATP diphosphatase activity
UC509_RS06115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UC509_RS06120	COG1054	Belongs to the UPF0176 family
UC509_RS06155	COG0473	3-isopropylmalate dehydrogenase activity
UC509_RS06180	COG0066	3-isopropylmalate dehydratase activity
UC509_RS06185	COG1119	ATPase activity
UC509_RS06200	COG0440	acetolactate synthase activity
UC509_RS06205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UC509_RS06210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UC509_RS06215	COG3527	Alpha-acetolactate decarboxylase
UC509_RS06220	COG0251	oxidation-reduction process
UC509_RS06225	COG0758	DNA mediated transformation
UC509_RS06230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UC509_RS06270	COG2801	Transposase and inactivated derivatives
UC509_RS06275	COG2963	transposase activity
UC509_RS06280	COG2801	Transposase and inactivated derivatives
UC509_RS06305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UC509_RS06310	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
UC509_RS06315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UC509_RS06320	COG1696	Membrane protein involved in D-alanine export
UC509_RS06325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UC509_RS06340	COG0351	phosphomethylpyrimidine kinase
UC509_RS06370	COG2814	Major facilitator Superfamily
UC509_RS06375	COG2963	transposase activity
UC509_RS06380	COG2801	Transposase and inactivated derivatives
UC509_RS06390	COG0222	ribosome binding
UC509_RS06395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UC509_RS06410	COG3620	sequence-specific DNA binding
UC509_RS06415	COG1132	(ABC) transporter
UC509_RS06420	COG1132	(ABC) transporter
UC509_RS06445	COG1187	pseudouridine synthase activity
UC509_RS06450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UC509_RS06460	COG4974	Belongs to the 'phage' integrase family
UC509_RS06475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UC509_RS06485	COG3763	UPF0154 protein
UC509_RS06495	COG0493	'glutamate synthase
UC509_RS06500	COG0067	glutamate synthase
UC509_RS06500	COG0069	glutamate synthase activity
UC509_RS06500	COG0070	glutamate synthase
UC509_RS06505	COG0110	maltose O-acetyltransferase activity
UC509_RS06510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UC509_RS06515	COG0668	transmembrane transport
UC509_RS06525	COG0531	amino acid
UC509_RS06570	COG1349	DNA-binding transcription factor activity
UC509_RS06595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
UC509_RS06600	COG0395	ABC-type sugar transport system, permease component
UC509_RS06625	COG0803	Belongs to the bacterial solute-binding protein 9 family
UC509_RS06650	COG0419	ATPase involved in DNA repair
UC509_RS06655	COG0420	3'-5' exonuclease activity
UC509_RS06660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UC509_RS06665	COG1393	Belongs to the ArsC family
UC509_RS06685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
UC509_RS06690	COG2226	methyltransferase
UC509_RS06695	COG3845	ABC transporter
UC509_RS06700	COG4603	Belongs to the binding-protein-dependent transport system permease family
UC509_RS06705	COG1079	Belongs to the binding-protein-dependent transport system permease family
UC509_RS06710	COG0039	L-malate dehydrogenase activity
UC509_RS06715	COG0469	pyruvate kinase activity
UC509_RS06720	COG0205	6-phosphofructokinase activity
UC509_RS06735	COG3853	Toxic anion resistance protein (TelA)
UC509_RS06745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UC509_RS06765	COG0142	geranyltranstransferase activity
UC509_RS06785	COG0167	dihydroorotate dehydrogenase activity
UC509_RS06795	COG2814	Major facilitator Superfamily
UC509_RS06800	COG2188	Transcriptional regulator
UC509_RS06805	COG2723	6-phospho-beta-galactosidase activity
UC509_RS06825	COG1175	transmembrane transport
UC509_RS06860	COG1187	pseudouridine synthase activity
UC509_RS06865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UC509_RS06870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UC509_RS06875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UC509_RS06890	COG2801	Transposase and inactivated derivatives
UC509_RS06895	COG2963	transposase activity
UC509_RS06920	COG0386	Belongs to the glutathione peroxidase family
UC509_RS06930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UC509_RS06945	COG2801	Transposase and inactivated derivatives
UC509_RS06960	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
UC509_RS06965	COG0745	RESPONSE REGULATOR receiver
UC509_RS06980	COG2188	Transcriptional regulator
UC509_RS06985	COG1744	ABC transporter substrate-binding protein PnrA-like
UC509_RS06995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UC509_RS07010	COG2813	Specifically methylates the guanine in position
UC509_RS07015	COG1072	(Pantothenic acid kinase))
UC509_RS07020	COG3223	Belongs to the PsiE family
UC509_RS07035	COG1475	DNA binding
UC509_RS07040	COG3969	phosphoadenosine phosphosulfate
UC509_RS07060	COG4175	Glycine betaine
UC509_RS07060	COG3448	diguanylate cyclase activity
UC509_RS07070	COG2723	6-phospho-beta-galactosidase activity
UC509_RS07080	COG3711	transcriptional antiterminator
UC509_RS07100	COG0135	phosphoribosylanthranilate isomerase activity
UC509_RS07105	COG0134	indole-3-glycerol-phosphate synthase activity
UC509_RS07120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UC509_RS07125	COG0512	Glutamine amidotransferase of anthranilate synthase
UC509_RS07130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UC509_RS07140	COG0778	Nitroreductase
UC509_RS07165	COG0735	belongs to the Fur family
UC509_RS07180	COG4221	oxidoreductase activity
UC509_RS07185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UC509_RS07190	COG1846	Transcriptional regulator
UC509_RS07215	COG1653	transport
UC509_RS07220	COG0395	ABC-type sugar transport system, permease component
UC509_RS07225	COG4209	transmembrane transport
UC509_RS07230	COG0519	Catalyzes the synthesis of GMP from XMP
UC509_RS07230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UC509_RS07250	COG2115	Belongs to the xylose isomerase family
UC509_RS07265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UC509_RS07270	COG0561	phosphatase activity
UC509_RS07275	COG0151	Belongs to the GarS family
UC509_RS07295	COG0138	bifunctional purine biosynthesis protein purh
UC509_RS07315	COG1132	(ABC) transporter
UC509_RS07320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UC509_RS07325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UC509_RS07330	COG0542	response to heat
UC509_RS07370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UC509_RS07400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UC509_RS07410	COG4221	oxidoreductase activity
UC509_RS07415	COG0477	Major facilitator Superfamily
UC509_RS07420	COG1846	Transcriptional regulator
UC509_RS07435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UC509_RS07450	COG2723	6-phospho-beta-galactosidase activity
UC509_RS07455	COG0698	ribose 5-phosphate isomerase
UC509_RS07460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UC509_RS07465	COG1609	Transcriptional regulator
UC509_RS07470	COG1063	alcohol dehydrogenase
UC509_RS07485	COG0167	dihydroorotate dehydrogenase activity
UC509_RS07490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UC509_RS07495	COG0673	inositol 2-dehydrogenase activity
UC509_RS07505	COG0488	(ABC) transporter
UC509_RS07515	COG0371	Dehydrogenase
UC509_RS07525	COG4690	dipeptidase activity
UC509_RS07530	COG0617	tRNA 3'-terminal CCA addition
UC509_RS07540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UC509_RS07545	COG1307	EDD domain protein, DegV family
UC509_RS07555	COG0336	Belongs to the RNA methyltransferase TrmD family
UC509_RS07575	COG1837	Belongs to the UPF0109 family
UC509_RS07580	COG0228	four-way junction DNA binding
UC509_RS07590	COG0183	Belongs to the thiolase family
UC509_RS07595	COG3425	synthase
UC509_RS07600	COG0363	glucosamine-6-phosphate deaminase activity
UC509_RS07610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UC509_RS07625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UC509_RS07635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UC509_RS07640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UC509_RS07645	COG0347	Belongs to the P(II) protein family
UC509_RS07650	COG0004	ammonium transporteR
UC509_RS07655	COG5002	protein histidine kinase activity
UC509_RS07660	COG0745	RESPONSE REGULATOR receiver
UC509_RS07670	COG0254	rRNA binding
UC509_RS07690	COG0505	Belongs to the CarA family
UC509_RS07720	COG1230	cation diffusion facilitator family transporter
UC509_RS07765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UC509_RS07770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UC509_RS07790	COG1285	pathogenesis
UC509_RS07805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UC509_RS07845	COG0800	Aldolase
UC509_RS07850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UC509_RS07870	COG1312	Catalyzes the dehydration of D-mannonate
UC509_RS07880	COG1802	Transcriptional regulator
UC509_RS07885	COG0477	Major facilitator Superfamily
UC509_RS07925	COG1869	D-ribose catabolic process
UC509_RS07930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UC509_RS07935	COG1609	Transcriptional regulator
UC509_RS07940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UC509_RS07960	COG3118	belongs to the thioredoxin family
UC509_RS07970	COG1286	toxin biosynthetic process
UC509_RS07980	COG1609	Transcriptional regulator
UC509_RS07985	COG0006	proline dipeptidase activity
UC509_RS07995	COG0116	Belongs to the methyltransferase superfamily
UC509_RS08005	COG3599	regulation of cell shape
UC509_RS08010	COG1466	dna polymerase III delta subunit
UC509_RS08020	COG1674	ftsk spoiiie
UC509_RS08025	COG0561	phosphatase activity
UC509_RS08035	COG0280	phosphate acetyltransferase
UC509_RS08040	COG0572	uridine kinase
UC509_RS08050	COG0673	inositol 2-dehydrogenase activity
UC509_RS08060	COG0741	lytic transglycosylase activity
UC509_RS08110	COG2723	6-phospho-beta-galactosidase activity
UC509_RS08120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UC509_RS08125	COG5002	protein histidine kinase activity
UC509_RS08130	COG0745	RESPONSE REGULATOR receiver
UC509_RS08135	COG1609	Transcriptional regulator
UC509_RS08155	COG0110	maltose O-acetyltransferase activity
UC509_RS08160	COG0366	Alpha amylase catalytic
UC509_RS08165	COG0366	Alpha amylase catalytic
UC509_RS08175	COG1175	transmembrane transport
UC509_RS08180	COG3833	ABC-type maltose transport systems, permease component
UC509_RS08190	COG2801	Transposase and inactivated derivatives
UC509_RS08195	COG2963	transposase activity
UC509_RS08235	COG3715	PTS system
UC509_RS08240	COG3716	PTS system mannose fructose sorbose family IID component
UC509_RS08260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UC509_RS08270	COG2801	Transposase and inactivated derivatives
UC509_RS08275	COG2963	transposase activity
UC509_RS08285	COG1619	proteins homologs of microcin C7 resistance protein MccF
UC509_RS08295	COG0704	Plays a role in the regulation of phosphate uptake
UC509_RS08300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UC509_RS08305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UC509_RS08310	COG0581	inorganic phosphate transmembrane transporter activity
UC509_RS08315	COG0573	inorganic phosphate transmembrane transporter activity
UC509_RS08330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UC509_RS08355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UC509_RS08360	COG4122	O-methyltransferase activity
UC509_RS08385	COG2252	PERMEase
UC509_RS08390	COG0561	phosphatase activity
UC509_RS08395	COG0247	lactate metabolic process
UC509_RS08405	COG1556	Lactate utilization protein
UC509_RS08410	COG0670	Belongs to the BI1 family
UC509_RS08425	COG0268	Binds directly to 16S ribosomal RNA
UC509_RS08430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UC509_RS08440	COG0077	Prephenate dehydratase
UC509_RS08455	COG0287	Prephenate dehydrogenase
UC509_RS08460	COG5002	protein histidine kinase activity
UC509_RS08465	COG0745	RESPONSE REGULATOR receiver
UC509_RS08475	COG0577	efflux transmembrane transporter activity
UC509_RS08480	COG1136	(ABC) transporter
UC509_RS08500	COG4493	Belongs to the UPF0637 family
UC509_RS08525	COG0765	amino acid transport
UC509_RS08530	COG1126	abc transporter atp-binding protein
UC509_RS08545	COG2801	Transposase and inactivated derivatives
UC509_RS08550	COG2963	transposase activity
UC509_RS08570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UC509_RS08580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UC509_RS08590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UC509_RS08595	COG0356	it plays a direct role in the translocation of protons across the membrane
UC509_RS08635	COG4152	abc transporter atp-binding protein
UC509_RS08655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UC509_RS08670	COG1268	BioY protein
UC509_RS08675	COG2801	Transposase and inactivated derivatives
UC509_RS08680	COG2963	transposase activity
UC509_RS08690	COG4842	Belongs to the WXG100 family
UC509_RS08695	COG0719	Fe-S assembly protein
UC509_RS08710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UC509_RS08715	COG0719	Fe-S assembly protein
UC509_RS08725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UC509_RS08730	COG4862	establishment of competence for transformation
UC509_RS08735	COG1126	abc transporter atp-binding protein
UC509_RS08740	COG0765	amino acid transport
UC509_RS08745	COG0085	RNA polymerase activity
UC509_RS08770	COG1396	sequence-specific DNA binding
UC509_RS08775	COG3590	peptidase
UC509_RS08785	COG2244	polysaccharide biosynthetic process
UC509_RS08800	COG1064	alcohol dehydrogenase
UC509_RS08805	COG0514	ATP-dependent DNA helicase (RecQ)
UC509_RS08820	COG2195	Cleaves the N-terminal amino acid of tripeptides
UC509_RS08830	COG1227	inorganic diphosphatase activity
UC509_RS08835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UC509_RS08840	COG1253	flavin adenine dinucleotide binding
UC509_RS08845	COG0628	permease
UC509_RS08875	COG1573	uracil-dna glycosylase
UC509_RS08880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UC509_RS08890	COG2827	Endonuclease containing a URI domain
UC509_RS08895	COG1113	amino acid transport
UC509_RS08905	COG1564	THIamine pyrophosphokinase
UC509_RS08935	COG0436	Aminotransferase
UC509_RS08945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UC509_RS08945	COG1199	ATP-dependent helicase activity
UC509_RS08960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UC509_RS08965	COG0601	transmembrane transport
UC509_RS08970	COG4608	Belongs to the ABC transporter superfamily
UC509_RS08975	COG0444	Belongs to the ABC transporter superfamily
UC509_RS08980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UC509_RS08985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UC509_RS08990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UC509_RS09025	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
UC509_RS09040	COG1045	serine acetyltransferase
UC509_RS09060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UC509_RS09065	COG0589	response to stress
UC509_RS09070	COG1104	cysteine desulfurase activity
UC509_RS09080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UC509_RS09090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UC509_RS09095	COG3599	regulation of cell shape
UC509_RS09100	COG2302	S4 RNA-binding domain
UC509_RS09115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UC509_RS09120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UC509_RS09125	COG0849	cell division
UC509_RS09130	COG1307	EDD domain protein, DegV family
UC509_RS09145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UC509_RS09150	COG0656	L-ascorbic acid biosynthetic process
UC509_RS09185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UC509_RS09195	COG0494	nUDIX hydrolase
UC509_RS09205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UC509_RS09210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UC509_RS09215	COG0515	serine threonine protein kinase
UC509_RS09215	COG2815	serine threonine protein kinase
UC509_RS09220	COG0631	protein serine/threonine phosphatase activity
UC509_RS09225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UC509_RS09225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UC509_RS09235	COG0463	Glycosyl transferase, family 2
UC509_RS09250	COG2963	transposase activity
UC509_RS09260	COG0756	dUTP diphosphatase activity
UC509_RS09315	COG2261	transglycosylase associated protein
UC509_RS09345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UC509_RS09350	COG1758	RNA polymerase activity
UC509_RS09355	COG0194	GDP metabolic process
UC509_RS09365	COG0363	glucosamine-6-phosphate deaminase activity
UC509_RS09375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UC509_RS09380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UC509_RS09380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UC509_RS09400	COG1705	Flagellar rod assembly protein muramidase FlgJ
UC509_RS09400	COG3942	CHAP domain
UC509_RS09405	COG0191	fructose-bisphosphate aldolase activity
UC509_RS09465	COG2860	membrane
UC509_RS09490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UC509_RS09500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UC509_RS09505	COG0626	cystathionine gamma-synthase activity
UC509_RS09510	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
UC509_RS09530	COG3481	metal-dependent phosphohydrolase, HD sub domain
UC509_RS09555	COG1162	GTPase activity
UC509_RS09560	COG1388	LysM domain
UC509_RS09560	COG3584	3D domain protein
UC509_RS09565	COG0072	phenylalanine-tRNA ligase activity
UC509_RS09565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC509_RS09575	COG3479	Phenolic acid decarboxylase
UC509_RS09590	COG3469	chitinase activity
UC509_RS09595	COG3397	chitin binding
UC509_RS09655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UC509_RS09665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UC509_RS09670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UC509_RS09675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UC509_RS09685	COG0537	adenosine 5'-monophosphoramidase activity
UC509_RS09715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UC509_RS09720	COG1426	Protein conserved in bacteria
UC509_RS09725	COG0612	Peptidase, M16
UC509_RS09730	COG0612	Peptidase, M16
UC509_RS09735	COG2501	S4 domain
UC509_RS09745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UC509_RS09760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UC509_RS09770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UC509_RS09810	COG0826	peptidase U32
UC509_RS09825	COG0500	methyltransferase
UC509_RS09840	COG1131	(ABC) transporter
UC509_RS09845	COG0584	glycerophosphoryl diester phosphodiesterase
UC509_RS09850	COG2801	Transposase and inactivated derivatives
UC509_RS09855	COG2963	transposase activity
UC509_RS09860	COG0537	adenosine 5'-monophosphoramidase activity
UC509_RS09875	COG0081	regulation of translation
UC509_RS09880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UC509_RS09890	COG1131	(ABC) transporter
UC509_RS09895	COG4479	Belongs to the UPF0346 family
UC509_RS09900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UC509_RS09905	COG2996	Protein conserved in bacteria
UC509_RS09930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UC509_RS09935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UC509_RS09940	COG0827	DNA restriction-modification system
UC509_RS09950	COG1217	gtp-binding protein TYPA
UC509_RS09960	COG2801	Transposase and inactivated derivatives
UC509_RS09965	COG2963	transposase activity
UC509_RS10000	COG1940	carbohydrate kinase activity
UC509_RS10010	COG0783	Belongs to the Dps family
UC509_RS10035	COG0531	amino acid
UC509_RS10050	COG0531	amino acid
UC509_RS10055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UC509_RS10060	COG2235	arginine
UC509_RS10080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UC509_RS10090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UC509_RS10100	COG2963	transposase activity
UC509_RS10105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UC509_RS10125	COG1266	CAAX protease self-immunity
UC509_RS10140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
UC509_RS10145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UC509_RS10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UC509_RS10165	COG1335	isochorismatase
UC509_RS10210	COG4956	integral membrane protein (PIN domain superfamily)
UC509_RS10230	COG1442	glycosyl transferase family 8
UC509_RS10230	COG1216	Glycosyl transferase, family 2
UC509_RS10235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UC509_RS10240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UC509_RS10260	COG1216	Glycosyl transferase, family 2
UC509_RS10265	COG1216	Glycosyl transferase, family 2
UC509_RS10280	COG0203	ribosomal protein L17
UC509_RS10285	COG0202	RNA polymerase activity
UC509_RS10290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UC509_RS10295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UC509_RS10300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UC509_RS10305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UC509_RS10310	COG0563	adenylate kinase activity
UC509_RS10320	COG0200	Binds to the 23S rRNA
UC509_RS10325	COG1841	ribosomal large subunit assembly
UC509_RS10330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UC509_RS10335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UC509_RS10345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UC509_RS10355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UC509_RS10360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UC509_RS10365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UC509_RS10370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UC509_RS10375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UC509_RS10380	COG0255	Belongs to the universal ribosomal protein uL29 family
UC509_RS10385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UC509_RS10390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UC509_RS10395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UC509_RS10400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UC509_RS10405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UC509_RS10420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UC509_RS10425	COG0051	transcription antitermination factor activity, RNA binding
UC509_RS10435	COG1970	mechanosensitive ion channel activity
UC509_RS10450	COG0250	Participates in transcription elongation, termination and antitermination
UC509_RS10460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UC509_RS10465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UC509_RS10465	COG2755	lipolytic protein G-D-S-L family
UC509_RS10470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UC509_RS10475	COG2323	membrane
UC509_RS10490	COG0564	pseudouridine synthase activity
UC509_RS10495	COG2801	Transposase and inactivated derivatives
UC509_RS10505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UC509_RS10510	COG1121	(ABC) transporter
UC509_RS10515	COG0803	Belongs to the bacterial solute-binding protein 9 family
UC509_RS10515	COG3443	Belongs to the bacterial solute-binding protein 9 family
UC509_RS10520	COG1846	Transcriptional regulator
UC509_RS10545	COG4537	Required for transformation and DNA binding
UC509_RS10550	COG1459	type II secretion system
UC509_RS10555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UC509_RS10560	COG2176	DNA-directed DNA polymerase activity
UC509_RS10575	COG0442	prolyl-tRNA aminoacylation
UC509_RS10580	COG0750	zinc metalloprotease
UC509_RS10585	COG4589	Belongs to the CDS family
UC509_RS10590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UC509_RS10595	COG1862	Preprotein translocase
UC509_RS10610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UC509_RS10620	COG0438	transferase activity, transferring glycosyl groups
UC509_RS10635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UC509_RS10640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UC509_RS10640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UC509_RS10650	COG1609	Transcriptional regulator
UC509_RS10680	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
UC509_RS10685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UC509_RS10690	COG0052	Belongs to the universal ribosomal protein uS2 family
UC509_RS10700	COG2706	6-phosphogluconolactonase activity
UC509_RS10705	COG1012	belongs to the aldehyde dehydrogenase family
UC509_RS10705	COG1454	alcohol dehydrogenase
UC509_RS10730	COG0535	radical SAM domain protein
UC509_RS10735	COG3480	Lon protease (S16) C-terminal proteolytic domain
UC509_RS10745	COG0742	ribosomal rna small subunit methyltransferase
UC509_RS10750	COG2814	Major facilitator Superfamily
UC509_RS10790	COG0702	epimerase
UC509_RS10795	COG1733	regulation of RNA biosynthetic process
UC509_RS10805	COG0525	valine-tRNA ligase activity
UC509_RS10840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UC509_RS10885	COG1070	Carbohydrate kinase
UC509_RS10890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
UC509_RS10905	COG1408	metallophosphoesterase
UC509_RS10910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UC509_RS10915	COG0629	single-stranded DNA binding
UC509_RS10920	COG0360	Binds together with S18 to 16S ribosomal RNA
UC509_RS10930	COG0833	amino acid
UC509_RS10935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UC509_RS10945	COG1956	GAF domain-containing protein
UC509_RS10950	COG1605	Chorismate mutase
UC509_RS10950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
UC509_RS10965	COG0174	glutamine synthetase
UC509_RS10970	COG0789	Transcriptional regulator
UC509_RS10975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UC509_RS10980	COG2255	four-way junction helicase activity
UC509_RS11030	COG0730	response to heat
UC509_RS11040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UC509_RS11045	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
UC509_RS11060	COG1794	racemase activity, acting on amino acids and derivatives
UC509_RS11070	COG0367	asparagine synthase
UC509_RS11075	COG3883	PFAM NLP P60 protein
UC509_RS11075	COG3942	CHAP domain
UC509_RS11090	COG0494	nUDIX hydrolase
UC509_RS11100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UC509_RS11105	COG2814	Major facilitator Superfamily
UC509_RS11110	COG0589	response to stress
UC509_RS11125	COG1309	transcriptional regulator
UC509_RS11130	COG1187	pseudouridine synthase activity
UC509_RS11165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UC509_RS11170	COG2824	Alkylphosphonate utilization operon protein PhnA
UC509_RS11200	COG1266	CAAX protease self-immunity
UC509_RS11260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UC509_RS11265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UC509_RS11275	COG1136	(ABC) transporter
UC509_RS11285	COG0681	Belongs to the peptidase S26 family
UC509_RS11290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UC509_RS11315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UC509_RS11320	COG0049	tRNA binding
UC509_RS11325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UC509_RS11340	COG1686	Belongs to the peptidase S11 family
UC509_RS11345	COG4975	Glucose uptake
UC509_RS11350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UC509_RS11355	COG1242	4 iron, 4 sulfur cluster binding
UC509_RS11395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS11500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UC509_RS11815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS11880	COG0012	GTP binding
UC509_RS11970	COG2213	PTS system mannitol-specific
UC509_RS12105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS12290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS12355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS12375	COG0592	DNA-directed DNA polymerase activity
UC509_RS12395	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UC509_RS12405	COG1074	ATP-dependent DNA helicase activity
UC509_RS12410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS12435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC509_RS12450	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UC509_RS12460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids