locus-tag	class	description
CV098_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CV098_RS00010	COG0592	DNA-directed DNA polymerase activity
CV098_RS00015	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CV098_RS00020	COG1074	ATP-dependent DNA helicase activity
CV098_RS00035	COG0012	GTP binding
CV098_RS00060	COG0193	aminoacyl-tRNA hydrolase activity
CV098_RS00065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CV098_RS00075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CV098_RS00095	COG0037	tRNA processing
CV098_RS00100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CV098_RS00105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CV098_RS00150	COG2213	PTS system mannitol-specific
CV098_RS00160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CV098_RS00165	COG0246	Mannitol dehydrogenase
CV098_RS00185	COG0659	secondary active sulfate transmembrane transporter activity
CV098_RS00200	COG0436	Aminotransferase
CV098_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
CV098_RS00235	COG0095	Lipoate-protein ligase
CV098_RS00240	COG0584	glycerophosphoryl diester phosphodiesterase
CV098_RS00245	COG1418	mRNA catabolic process
CV098_RS00250	COG0180	Tryptophanyl-tRNA synthetase
CV098_RS00255	COG1764	response to oxidative stress
CV098_RS00270	COG0416	fatty acid biosynthetic process
CV098_RS00280	COG0488	(ABC) transporter
CV098_RS00295	COG4221	oxidoreductase activity
CV098_RS00310	COG0400	carboxylic ester hydrolase activity
CV098_RS00315	COG0346	lactoylglutathione lyase activity
CV098_RS00320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CV098_RS00335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CV098_RS00340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CV098_RS00345	COG2217	Heavy metal translocating P-type atpase
CV098_RS00350	COG1475	DNA binding
CV098_RS00355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CV098_RS00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CV098_RS00370	COG0488	(ABC) transporter
CV098_RS00385	COG2264	protein methyltransferase activity
CV098_RS00390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CV098_RS00395	COG0726	polysaccharide deacetylase
CV098_RS00410	COG1490	D-aminoacyl-tRNA deacylase activity
CV098_RS00420	COG1011	Hydrolase
CV098_RS00425	COG0531	amino acid
CV098_RS00430	COG0204	Acyl-transferase
CV098_RS00440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CV098_RS00445	COG0653	protein targeting
CV098_RS00450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CV098_RS00460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CV098_RS00470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CV098_RS00485	COG2076	Multidrug Resistance protein
CV098_RS00490	COG2814	Major facilitator Superfamily
CV098_RS00500	COG0137	argininosuccinate synthase activity
CV098_RS00505	COG0165	Argininosuccinate lyase
CV098_RS00520	COG0594	ribonuclease P activity
CV098_RS00525	COG0706	membrane insertase activity
CV098_RS00535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CV098_RS00540	COG4989	oxidoreductase activity
CV098_RS00545	COG4472	Bacterial protein of unknown function (DUF965)
CV098_RS00550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CV098_RS00555	COG3906	Belongs to the UPF0473 family
CV098_RS00565	COG0300	oxidoreductase activity
CV098_RS00575	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CV098_RS00580	COG1309	transcriptional regulator
CV098_RS00585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CV098_RS00615	COG0489	protein tyrosine kinase activity
CV098_RS00620	COG4464	protein tyrosine phosphatase activity
CV098_RS00625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CV098_RS00640	COG1216	Glycosyl transferase, family 2
CV098_RS00640	COG1442	glycosyl transferase family 8
CV098_RS00655	COG2244	polysaccharide biosynthetic process
CV098_RS00665	COG1316	TRANSCRIPTIONal
CV098_RS00670	COG0582	viral genome integration into host DNA
CV098_RS00680	COG0343	queuine tRNA-ribosyltransferase activity
CV098_RS00690	COG2814	Major facilitator Superfamily
CV098_RS00695	COG1832	CoA-binding protein
CV098_RS00720	COG0436	Aminotransferase
CV098_RS00725	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CV098_RS00730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CV098_RS00735	COG0154	amidase activity
CV098_RS00740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CV098_RS00760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CV098_RS00785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CV098_RS00800	COG2723	6-phospho-beta-galactosidase activity
CV098_RS00805	COG0756	dUTP diphosphatase activity
CV098_RS00810	COG0737	Belongs to the 5'-nucleotidase family
CV098_RS00815	COG4470	Protein conserved in bacteria
CV098_RS00820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CV098_RS00830	COG0142	geranyltranstransferase activity
CV098_RS00860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CV098_RS00865	COG1461	Dihydroxyacetone kinase
CV098_RS00875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CV098_RS00885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CV098_RS00905	COG1088	dTDP-glucose 4,6-dehydratase activity
CV098_RS00925	COG0463	Glycosyl transferase, family 2
CV098_RS00945	COG1216	Glycosyl transferase, family 2
CV098_RS00945	COG1442	glycosyl transferase family 8
CV098_RS00980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CV098_RS00980	COG1215	transferase activity, transferring glycosyl groups
CV098_RS00995	COG1216	Glycosyl transferase, family 2
CV098_RS00995	COG1442	glycosyl transferase family 8
CV098_RS01000	COG3475	LICD family
CV098_RS01005	COG2244	polysaccharide biosynthetic process
CV098_RS01010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CV098_RS01020	COG0517	IMP dehydrogenase activity
CV098_RS01020	COG0516	GMP reductase activity
CV098_RS01025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CV098_RS01030	COG0494	nUDIX hydrolase
CV098_RS01035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CV098_RS01040	COG1534	Rna-binding protein
CV098_RS01050	COG1713	HD superfamily hydrolase involved in NAD metabolism
CV098_RS01060	COG0799	negative regulation of ribosome biogenesis
CV098_RS01065	COG2226	methyltransferase
CV098_RS01070	COG1323	Belongs to the UPF0348 family
CV098_RS01080	COG0217	transcriptional regulatory protein
CV098_RS01090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CV098_RS01100	COG1309	transcriptional regulator
CV098_RS01105	COG0477	Major facilitator Superfamily
CV098_RS01115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CV098_RS01120	COG0561	phosphatase activity
CV098_RS01130	COG2376	Dihydroxyacetone kinase
CV098_RS01135	COG1309	transcriptional regulator
CV098_RS01140	COG2376	Dihydroxyacetone kinase
CV098_RS01145	COG1461	Dihydroxyacetone kinase
CV098_RS01150	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CV098_RS01155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CV098_RS01160	COG4690	dipeptidase activity
CV098_RS01170	COG1131	(ABC) transporter
CV098_RS01180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CV098_RS01185	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CV098_RS01195	COG2081	HI0933 family
CV098_RS01200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CV098_RS01215	COG1132	(ABC) transporter
CV098_RS01225	COG0673	inositol 2-dehydrogenase activity
CV098_RS01230	COG1854	S-ribosylhomocysteine lyase activity
CV098_RS01240	COG0656	L-ascorbic acid biosynthetic process
CV098_RS01245	COG1335	isochorismatase
CV098_RS01260	COG1388	LysM domain
CV098_RS01260	COG1705	Flagellar rod assembly protein muramidase FlgJ
CV098_RS01265	COG1328	CTP reductase activity
CV098_RS01280	COG0148	phosphopyruvate hydratase activity
CV098_RS01290	COG1122	ATPase activity
CV098_RS01300	COG1122	ATPase activity
CV098_RS01305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CV098_RS01315	COG2171	N-acyltransferase activity
CV098_RS01320	COG1473	amidohydrolase
CV098_RS01325	COG0726	polysaccharide deacetylase
CV098_RS01340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CV098_RS01345	COG2183	response to ionizing radiation
CV098_RS01350	COG3091	SprT-like family
CV098_RS01355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CV098_RS01370	COG5503	Protein of unknown function (DUF1447)
CV098_RS01385	COG0456	acetyltransferase
CV098_RS01390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CV098_RS01415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CV098_RS01425	COG3639	organic phosphonate transmembrane transporter activity
CV098_RS01430	COG0737	Belongs to the 5'-nucleotidase family
CV098_RS01435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CV098_RS01440	COG0308	aminopeptidase N
CV098_RS01450	COG1846	Transcriptional regulator
CV098_RS01455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CV098_RS01475	COG1132	(ABC) transporter
CV098_RS01480	COG1132	(ABC) transporter
CV098_RS01485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CV098_RS01490	COG4443	Transcriptional Coactivator p15 (PC4)
CV098_RS01500	COG1268	BioY protein
CV098_RS01505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CV098_RS01510	COG3859	Proton-coupled thiamine transporter YuaJ
CV098_RS01515	COG1464	Belongs to the NlpA lipoprotein family
CV098_RS01525	COG1464	Belongs to the NlpA lipoprotein family
CV098_RS01535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CV098_RS01540	COG2011	ABC-type metal ion transport system permease component
CV098_RS01545	COG4720	Psort location CytoplasmicMembrane, score
CV098_RS01550	COG1122	ATPase activity
CV098_RS01565	COG1120	ATPase activity
CV098_RS01570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CV098_RS01575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CV098_RS01580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CV098_RS01590	COG2814	Major facilitator Superfamily
CV098_RS01595	COG0656	L-ascorbic acid biosynthetic process
CV098_RS01600	COG1733	regulation of RNA biosynthetic process
CV098_RS01605	COG0346	lactoylglutathione lyase activity
CV098_RS01610	COG0588	phosphoglycerate mutase activity
CV098_RS01615	COG0450	alkyl hydroperoxide reductase
CV098_RS01620	COG3634	alkyl hydroperoxide reductase activity
CV098_RS01625	COG0768	penicillin binding
CV098_RS01630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CV098_RS01635	COG1181	Belongs to the D-alanine--D-alanine ligase family
CV098_RS01640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CV098_RS01645	COG4166	transmembrane transport
CV098_RS01650	COG4166	transmembrane transport
CV098_RS01655	COG0601	transmembrane transport
CV098_RS01660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CV098_RS01665	COG0444	Belongs to the ABC transporter superfamily
CV098_RS01670	COG4608	Belongs to the ABC transporter superfamily
CV098_RS01675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CV098_RS01680	COG0513	Belongs to the DEAD box helicase family
CV098_RS01685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CV098_RS01690	COG0367	asparagine synthase
CV098_RS01695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CV098_RS01700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CV098_RS01705	COG1113	amino acid transport
CV098_RS01710	COG1113	amino acid transport
CV098_RS01720	COG4471	UPF0298 protein
CV098_RS01740	COG2357	RelA SpoT domain protein
CV098_RS01745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CV098_RS01750	COG0564	pseudouridine synthase activity
CV098_RS01760	COG0833	amino acid
CV098_RS01775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CV098_RS01780	COG0583	DNA-binding transcription factor activity
CV098_RS01785	COG2855	membrane
CV098_RS01790	COG0039	L-malate dehydrogenase activity
CV098_RS01795	COG0583	DNA-binding transcription factor activity
CV098_RS01805	COG0301	tRNA thio-modification
CV098_RS01810	COG2814	Major facilitator Superfamily
CV098_RS01815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CV098_RS01820	COG1764	response to oxidative stress
CV098_RS01825	COG0025	NhaP-type Na H and K H
CV098_RS01835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CV098_RS01845	COG1363	Peptidase, m42
CV098_RS01855	COG3118	belongs to the thioredoxin family
CV098_RS01860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV098_RS01865	COG0446	pyridine nucleotide-disulphide oxidoreductase
CV098_RS01875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CV098_RS01880	COG0459	protein refolding
CV098_RS01885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CV098_RS01890	COG5002	protein histidine kinase activity
CV098_RS01895	COG0745	RESPONSE REGULATOR receiver
CV098_RS01900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CV098_RS01905	COG0470	DNA polymerase III
CV098_RS01910	COG1774	PSP1 C-terminal conserved region
CV098_RS01930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CV098_RS01945	COG1304	FMN binding
CV098_RS01950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CV098_RS01955	COG1966	Carbon starvation protein
CV098_RS01960	COG0513	Belongs to the DEAD box helicase family
CV098_RS01970	COG1737	Transcriptional regulator
CV098_RS01975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CV098_RS01980	COG1447	Phosphotransferase system cellobiose-specific component IIA
CV098_RS01985	COG1737	Transcriptional regulator
CV098_RS01990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CV098_RS01995	COG2723	6-phospho-beta-galactosidase activity
CV098_RS02010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CV098_RS02015	COG1597	lipid kinase activity
CV098_RS02020	COG3842	ATPase activity
CV098_RS02040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CV098_RS02045	COG2188	Transcriptional regulator
CV098_RS02050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CV098_RS02050	COG1263	PTS System
CV098_RS02050	COG2190	(PTS) system
CV098_RS02055	COG1263	PTS System
CV098_RS02055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CV098_RS02060	COG1554	hydrolase, family 65, central catalytic
CV098_RS02065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CV098_RS02070	COG0657	acetylesterase activity
CV098_RS02070	COG2755	lipolytic protein G-D-S-L family
CV098_RS02085	COG0802	atpase or kinase
CV098_RS02095	COG1316	TRANSCRIPTIONal
CV098_RS02105	COG0101	tRNA pseudouridine synthase activity
CV098_RS02110	COG0351	phosphomethylpyrimidine kinase
CV098_RS02115	COG4720	Psort location CytoplasmicMembrane, score
CV098_RS02120	COG4475	Protein of unknown function (DUF436)
CV098_RS02125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CV098_RS02130	COG0504	CTP synthase activity
CV098_RS02155	COG1611	Belongs to the LOG family
CV098_RS02160	COG1428	Deoxynucleoside kinase
CV098_RS02165	COG0587	DNA-directed DNA polymerase activity
CV098_RS02170	COG1272	protein, Hemolysin III
CV098_RS02175	COG1307	EDD domain protein, DegV family
CV098_RS02180	COG2755	lipolytic protein G-D-S-L family
CV098_RS02195	COG0776	regulation of translation
CV098_RS02205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CV098_RS02210	COG2169	Transcriptional regulator
CV098_RS02235	COG1104	cysteine desulfurase activity
CV098_RS02245	COG4166	transmembrane transport
CV098_RS02255	COG1705	Flagellar rod assembly protein muramidase FlgJ
CV098_RS02255	COG1388	LysM domain
CV098_RS02270	COG3331	DNA recombination
CV098_RS02275	COG4474	Belongs to the UPF0398 family
CV098_RS02280	COG1393	Belongs to the ArsC family
CV098_RS02285	COG4476	Belongs to the UPF0223 family
CV098_RS02290	COG0483	inositol monophosphate 1-phosphatase activity
CV098_RS02295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CV098_RS02305	COG0544	peptidyl-prolyl cis-trans isomerase activity
CV098_RS02400	COG0358	DNA primase activity
CV098_RS02405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CV098_RS02425	COG0542	response to heat
CV098_RS02430	COG1959	2 iron, 2 sulfur cluster binding
CV098_RS02435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CV098_RS02440	COG0242	peptide deformylase activity
CV098_RS02445	COG0494	nUDIX hydrolase
CV098_RS02450	COG0556	nucleotide-excision repair
CV098_RS02455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CV098_RS02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CV098_RS02465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CV098_RS02470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CV098_RS02475	COG0706	membrane insertase activity
CV098_RS02485	COG4684	Psort location CytoplasmicMembrane, score
CV098_RS02490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CV098_RS02500	COG1942	4-Oxalocrotonate Tautomerase
CV098_RS02505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS02535	COG1461	Dihydroxyacetone kinase
CV098_RS02570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CV098_RS02585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CV098_RS02600	COG1764	response to oxidative stress
CV098_RS02605	COG1435	thymidine kinase activity
CV098_RS02615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CV098_RS02630	COG2890	protein-(glutamine-N5) methyltransferase activity
CV098_RS02640	COG0009	L-threonylcarbamoyladenylate synthase
CV098_RS02645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CV098_RS02650	COG0741	lytic transglycosylase activity
CV098_RS02655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CV098_RS02660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CV098_RS02665	COG0560	Phosphoserine phosphatase
CV098_RS02670	COG1254	Belongs to the acylphosphatase family
CV098_RS02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CV098_RS02680	COG0716	FMN binding
CV098_RS02685	COG0477	Major facilitator Superfamily
CV098_RS02695	COG0024	Methionine aminopeptidase
CV098_RS02705	COG2246	polysaccharide biosynthetic process
CV098_RS02725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CV098_RS02730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CV098_RS02740	COG4980	gas vesicle protein
CV098_RS02745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CV098_RS02750	COG3158	transport of potassium into the cell
CV098_RS02755	COG3158	transport of potassium into the cell
CV098_RS02770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CV098_RS02800	COG1234	tRNA 3'-trailer cleavage
CV098_RS02805	COG0300	oxidoreductase activity
CV098_RS02810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CV098_RS02810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CV098_RS02815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CV098_RS02825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CV098_RS02830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CV098_RS02835	COG4463	regulation of RNA biosynthetic process
CV098_RS02840	COG0542	response to heat
CV098_RS02845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CV098_RS02850	COG0148	phosphopyruvate hydratase activity
CV098_RS02860	COG0577	efflux transmembrane transporter activity
CV098_RS02870	COG0318	PFAM AMP-dependent synthetase and ligase
CV098_RS02880	COG1882	Formate acetyltransferase
CV098_RS02885	COG0237	dephospho-CoA kinase activity
CV098_RS02890	COG2814	Major facilitator Superfamily
CV098_RS02895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CV098_RS02900	COG0772	Belongs to the SEDS family
CV098_RS02905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CV098_RS02910	COG0372	Belongs to the citrate synthase family
CV098_RS02915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CV098_RS02925	COG0740	serine-type endopeptidase activity
CV098_RS02935	COG1393	Belongs to the ArsC family
CV098_RS02945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS02975	COG1114	Component of the transport system for branched-chain amino acids
CV098_RS02985	COG3592	Divergent 4Fe-4S mono-cluster
CV098_RS03035	COG1131	(ABC) transporter
CV098_RS03055	COG3706	GGDEF domain
CV098_RS03060	COG1215	transferase activity, transferring glycosyl groups
CV098_RS03165	COG1278	Cold shock
CV098_RS03185	COG1175	transmembrane transport
CV098_RS03190	COG0395	ABC-type sugar transport system, permease component
CV098_RS03195	COG0366	Alpha amylase catalytic
CV098_RS03200	COG1113	amino acid transport
CV098_RS03220	COG0582	viral genome integration into host DNA
CV098_RS03225	COG0084	hydrolase, TatD family'
CV098_RS03230	COG3271	cysteine-type peptidase activity
CV098_RS03230	COG2274	protein secretion by the type I secretion system
CV098_RS03235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CV098_RS03240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CV098_RS03245	COG0006	proline dipeptidase activity
CV098_RS03250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CV098_RS03260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CV098_RS03265	COG1640	4-alpha-glucanotransferase
CV098_RS03270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CV098_RS03275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CV098_RS03280	COG0297	glycogen (starch) synthase activity
CV098_RS03285	COG0058	SHG alpha-glucan phosphorylase activity
CV098_RS03295	COG3104	oligopeptide transport
CV098_RS03300	COG1271	oxidase subunit
CV098_RS03305	COG1294	oxidase, subunit
CV098_RS03310	COG4988	ABC transporter
CV098_RS03315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CV098_RS03320	COG1846	Transcriptional regulator
CV098_RS03335	COG1132	(ABC) transporter
CV098_RS03345	COG0586	Pfam SNARE associated Golgi protein
CV098_RS03370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CV098_RS03375	COG1234	tRNA 3'-trailer cleavage
CV098_RS03410	COG4948	Mandelate Racemase Muconate Lactonizing
CV098_RS03415	COG0318	PFAM AMP-dependent synthetase and ligase
CV098_RS03420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CV098_RS03425	COG2267	carboxylic ester hydrolase activity
CV098_RS03430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CV098_RS03435	COG1169	isochorismate synthase
CV098_RS03440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CV098_RS03445	COG4109	DRTGG domain
CV098_RS03450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CV098_RS03455	COG0252	asparaginase activity
CV098_RS03460	COG0561	phosphatase activity
CV098_RS03470	COG2268	Band 7 protein
CV098_RS03475	COG0527	aspartate kinase activity
CV098_RS03485	COG1846	Transcriptional regulator
CV098_RS03490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CV098_RS03500	COG0359	binds to the 23S rRNA
CV098_RS03505	COG0305	Participates in initiation and elongation during chromosome replication
CV098_RS03520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CV098_RS03525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CV098_RS03540	COG1484	DNA-dependent DNA replication
CV098_RS03545	COG0778	Nitroreductase
CV098_RS03555	COG1160	GTP binding
CV098_RS03585	COG1346	cytolysis
CV098_RS03595	COG0779	Required for maturation of 30S ribosomal subunits
CV098_RS03600	COG0195	Participates in both transcription termination and antitermination
CV098_RS03605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CV098_RS03615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CV098_RS03620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CV098_RS03625	COG1482	cell wall glycoprotein biosynthetic process
CV098_RS03635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CV098_RS03640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CV098_RS03645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CV098_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
CV098_RS03655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CV098_RS03665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CV098_RS03675	COG0439	Biotin carboxylase
CV098_RS03680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CV098_RS03690	COG0626	cystathionine gamma-synthase activity
CV098_RS03710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CV098_RS03715	COG0446	pyridine nucleotide-disulphide oxidoreductase
CV098_RS03725	COG1393	Belongs to the ArsC family
CV098_RS03730	COG1349	DNA-binding transcription factor activity
CV098_RS03740	COG0708	Exodeoxyribonuclease III
CV098_RS03745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV098_RS03745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV098_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
CV098_RS03765	COG4708	membrane
CV098_RS03770	COG2910	NAD(P)H-binding
CV098_RS03775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CV098_RS03780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CV098_RS03785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CV098_RS03790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CV098_RS03795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CV098_RS03800	COG0571	ribonuclease III activity
CV098_RS03805	COG1196	nuclear chromosome segregation
CV098_RS03810	COG1368	sulfuric ester hydrolase activity
CV098_RS03830	COG1113	amino acid transport
CV098_RS03835	COG0561	phosphatase activity
CV098_RS03845	COG0552	protein localization to endoplasmic reticulum
CV098_RS03845	COG0552	protein localization to endoplasmic reticulum
CV098_RS03850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CV098_RS03860	COG0495	leucyl-tRNA aminoacylation
CV098_RS03870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CV098_RS03875	COG2723	6-phospho-beta-galactosidase activity
CV098_RS03890	COG1252	NADH dehydrogenase
CV098_RS03895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CV098_RS03900	COG1760	l-serine dehydratase
CV098_RS03905	COG1760	l-serine dehydratase
CV098_RS03910	COG3682	Transcriptional regulator
CV098_RS03920	COG2217	Heavy metal translocating P-type atpase
CV098_RS03935	COG0482	sulfurtransferase activity
CV098_RS03940	COG0539	negative regulation of cytoplasmic translation
CV098_RS03945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CV098_RS03950	COG3201	nicotinamide mononucleotide transporter
CV098_RS03955	COG0322	excinuclease ABC activity
CV098_RS03970	COG0736	holo-[acyl-carrier-protein] synthase activity
CV098_RS03975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CV098_RS03985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CV098_RS03995	COG1174	glycine betaine transport
CV098_RS04015	COG2217	Heavy metal translocating P-type atpase
CV098_RS04025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CV098_RS04030	COG1570	exodeoxyribonuclease VII activity
CV098_RS04035	COG1722	exodeoxyribonuclease VII activity
CV098_RS04040	COG1929	Belongs to the glycerate kinase type-1 family
CV098_RS04050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CV098_RS04055	COG1438	arginine binding
CV098_RS04060	COG0497	DNA recombination
CV098_RS04085	COG0275	rRNA processing
CV098_RS04095	COG0768	penicillin binding
CV098_RS04100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CV098_RS04110	COG0577	efflux transmembrane transporter activity
CV098_RS04115	COG1136	(ABC) transporter
CV098_RS04120	COG0583	DNA-binding transcription factor activity
CV098_RS04125	COG2357	RelA SpoT domain protein
CV098_RS04130	COG0335	large ribosomal subunit rRNA binding
CV098_RS04140	COG1215	transferase activity, transferring glycosyl groups
CV098_RS04155	COG0589	response to stress
CV098_RS04170	COG1511	domain protein
CV098_RS04175	COG2151	metal-sulfur cluster biosynthetic enzyme
CV098_RS04180	COG1120	ATPase activity
CV098_RS04185	COG2819	hydrolase of the alpha beta superfamily
CV098_RS04190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CV098_RS04195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CV098_RS04200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CV098_RS04210	COG3942	CHAP domain
CV098_RS04210	COG3883	PFAM NLP P60 protein
CV098_RS04225	COG0772	Belongs to the SEDS family
CV098_RS04230	COG1316	TRANSCRIPTIONal
CV098_RS04235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CV098_RS04245	COG4585	Histidine kinase
CV098_RS04250	COG2197	response regulator
CV098_RS04265	COG0539	negative regulation of cytoplasmic translation
CV098_RS04275	COG0772	Belongs to the SEDS family
CV098_RS04280	COG1063	alcohol dehydrogenase
CV098_RS04295	COG0281	malic enzyme
CV098_RS04320	COG0187	DNA topoisomerase II activity
CV098_RS04345	COG2814	Major facilitator Superfamily
CV098_RS04360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CV098_RS04370	COG0813	purine-nucleoside phosphorylase activity
CV098_RS04380	COG0393	Putative heavy-metal-binding
CV098_RS04385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CV098_RS04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CV098_RS04400	COG0765	amino acid transport
CV098_RS04405	COG1126	abc transporter atp-binding protein
CV098_RS04415	COG0492	ferredoxin-NADP+ reductase activity
CV098_RS04425	COG0557	exoribonuclease II activity
CV098_RS04445	COG3830	Belongs to the UPF0237 family
CV098_RS04450	COG2848	UPF0210 protein
CV098_RS04460	COG0588	phosphoglycerate mutase activity
CV098_RS04475	COG1420	regulation of RNA biosynthetic process
CV098_RS04480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CV098_RS04485	COG0443	Heat shock 70 kDa protein
CV098_RS04495	COG1473	amidohydrolase
CV098_RS04500	COG1349	DNA-binding transcription factor activity
CV098_RS04505	COG1105	Belongs to the carbohydrate kinase PfkB family
CV098_RS04510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CV098_RS04510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CV098_RS04510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CV098_RS04515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CV098_RS04520	COG1660	Displays ATPase and GTPase activities
CV098_RS04525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CV098_RS04530	COG1481	regulation of sporulation
CV098_RS04540	COG1131	(ABC) transporter
CV098_RS04555	COG2116	formate transmembrane transporter activity
CV098_RS04570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CV098_RS04575	COG2884	Cell division ATP-binding protein ftsE
CV098_RS04580	COG2177	Part of the ABC transporter FtsEX involved in
CV098_RS04585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CV098_RS04595	COG1780	Probably involved in ribonucleotide reductase function
CV098_RS04600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CV098_RS04605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CV098_RS04610	COG0187	DNA topoisomerase II activity
CV098_RS04620	COG2176	DNA-directed DNA polymerase activity
CV098_RS04625	COG2153	protein acetylation
CV098_RS04650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CV098_RS04650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CV098_RS04655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CV098_RS04660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CV098_RS04665	COG0564	pseudouridine synthase activity
CV098_RS04680	COG0463	Glycosyl transferase, family 2
CV098_RS04685	COG0745	RESPONSE REGULATOR receiver
CV098_RS04695	COG5002	protein histidine kinase activity
CV098_RS04700	COG0671	phosphoesterase, PA-phosphatase related
CV098_RS04705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CV098_RS04710	COG2003	Belongs to the UPF0758 family
CV098_RS04715	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CV098_RS04720	COG1393	Belongs to the ArsC family
CV098_RS04725	COG0488	(ABC) transporter
CV098_RS04755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CV098_RS04760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CV098_RS04770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CV098_RS04775	COG2384	SAM-dependent methyltransferase
CV098_RS04780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CV098_RS04795	COG1078	dGTPase activity
CV098_RS04810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CV098_RS04820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CV098_RS04825	COG1914	H( )-stimulated, divalent metal cation uptake system
CV098_RS04830	COG1702	phosphate starvation-inducible protein PhoH
CV098_RS04840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CV098_RS04845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CV098_RS04860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CV098_RS04865	COG1739	Uncharacterized protein family UPF0029
CV098_RS04885	COG0752	glycyl-tRNA synthetase alpha subunit
CV098_RS04890	COG0751	glycine-tRNA ligase activity
CV098_RS04895	COG4224	UPF0291 protein
CV098_RS04900	COG0038	chloride channel
CV098_RS04905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CV098_RS04915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CV098_RS04925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CV098_RS04930	COG1136	(ABC) transporter
CV098_RS04940	COG3442	glutamine amidotransferase
CV098_RS04945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CV098_RS04950	COG3527	Alpha-acetolactate decarboxylase
CV098_RS04955	COG0481	GTPase activity
CV098_RS04960	COG0702	epimerase
CV098_RS04965	COG0531	amino acid
CV098_RS04980	COG3764	Sortase (surface protein transpeptidase)
CV098_RS04990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CV098_RS04990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CV098_RS05005	COG0210	DNA helicase
CV098_RS05010	COG2816	NAD+ diphosphatase activity
CV098_RS05015	COG0519	Catalyzes the synthesis of GMP from XMP
CV098_RS05035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CV098_RS05040	COG0196	riboflavin kinase activity
CV098_RS05045	COG0039	L-malate dehydrogenase activity
CV098_RS05055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CV098_RS05060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CV098_RS05060	COG1263	PTS System
CV098_RS05065	COG1737	Transcriptional regulator
CV098_RS05070	COG0149	triose-phosphate isomerase activity
CV098_RS05085	COG3969	phosphoadenosine phosphosulfate
CV098_RS05090	COG1475	DNA binding
CV098_RS05095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CV098_RS05125	COG0516	GMP reductase activity
CV098_RS05130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CV098_RS05135	COG2233	PERMEase
CV098_RS05145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CV098_RS05150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CV098_RS05160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CV098_RS05165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CV098_RS05175	COG0302	gtp cyclohydrolase
CV098_RS05175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CV098_RS05180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CV098_RS05185	COG1051	belongs to the nudix hydrolase family
CV098_RS05190	COG0285	dihydrofolate synthase activity
CV098_RS05195	COG1428	Deoxynucleoside kinase
CV098_RS05200	COG0460	homoserine dehydrogenase
CV098_RS05205	COG0083	homoserine kinase activity
CV098_RS05215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CV098_RS05220	COG3842	ATPase activity
CV098_RS05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
CV098_RS05230	COG1177	transmembrane transport
CV098_RS05250	COG0346	lactoylglutathione lyase activity
CV098_RS05275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CV098_RS05280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS05285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CV098_RS05295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CV098_RS05300	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CV098_RS05305	COG2226	methyltransferase
CV098_RS05310	COG0628	permease
CV098_RS05320	COG0028	Belongs to the TPP enzyme family
CV098_RS05360	COG0300	oxidoreductase activity
CV098_RS05360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CV098_RS05360	COG3321	synthase
CV098_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
CV098_RS05360	COG0318	PFAM AMP-dependent synthetase and ligase
CV098_RS05365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CV098_RS05380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CV098_RS05465	COG2205	protein histidine kinase activity
CV098_RS05470	COG0745	RESPONSE REGULATOR receiver
CV098_RS05480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CV098_RS05485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CV098_RS05490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CV098_RS05510	COG0557	exoribonuclease II activity
CV098_RS05515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CV098_RS05520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CV098_RS05525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CV098_RS05530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CV098_RS05540	COG0131	Imidazoleglycerol-phosphate dehydratase
CV098_RS05545	COG3231	kanamycin kinase activity
CV098_RS05550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CV098_RS05555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CV098_RS05560	COG0107	imidazoleglycerol-phosphate synthase activity
CV098_RS05565	COG0140	phosphoribosyl-ATP diphosphatase activity
CV098_RS05565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CV098_RS05570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CV098_RS05575	COG1054	Belongs to the UPF0176 family
CV098_RS05585	COG0473	3-isopropylmalate dehydrogenase activity
CV098_RS05595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CV098_RS05600	COG0066	3-isopropylmalate dehydratase activity
CV098_RS05605	COG1119	ATPase activity
CV098_RS05610	COG0129	dihydroxy-acid dehydratase activity
CV098_RS05615	COG0028	Belongs to the TPP enzyme family
CV098_RS05620	COG0440	acetolactate synthase activity
CV098_RS05625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CV098_RS05630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CV098_RS05635	COG3527	Alpha-acetolactate decarboxylase
CV098_RS05640	COG0251	oxidation-reduction process
CV098_RS05645	COG0758	DNA mediated transformation
CV098_RS05650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CV098_RS05655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CV098_RS05660	COG4974	Belongs to the 'phage' integrase family
CV098_RS05670	COG4974	Belongs to the 'phage' integrase family
CV098_RS05725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CV098_RS05740	COG1131	(ABC) transporter
CV098_RS05745	COG1725	Transcriptional regulator
CV098_RS05750	COG0657	acetylesterase activity
CV098_RS05770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CV098_RS05775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CV098_RS05780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CV098_RS05795	COG0025	NhaP-type Na H and K H
CV098_RS05800	COG0438	transferase activity, transferring glycosyl groups
CV098_RS05800	COG4641	Protein conserved in bacteria
CV098_RS05810	COG1304	FMN binding
CV098_RS05815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CV098_RS05820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CV098_RS05825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CV098_RS05835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS05840	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CV098_RS05845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CV098_RS05850	COG1696	Membrane protein involved in D-alanine export
CV098_RS05855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CV098_RS05865	COG0352	thiamine-phosphate diphosphorylase activity
CV098_RS05870	COG0351	phosphomethylpyrimidine kinase
CV098_RS05875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CV098_RS05885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CV098_RS05895	COG0222	ribosome binding
CV098_RS05900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CV098_RS05910	COG3620	sequence-specific DNA binding
CV098_RS05915	COG1132	(ABC) transporter
CV098_RS05920	COG1132	(ABC) transporter
CV098_RS05930	COG1187	pseudouridine synthase activity
CV098_RS05935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CV098_RS05940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CV098_RS05945	COG4974	Belongs to the 'phage' integrase family
CV098_RS05960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CV098_RS05965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CV098_RS05970	COG3763	UPF0154 protein
CV098_RS05980	COG0493	'glutamate synthase
CV098_RS05985	COG0067	glutamate synthase
CV098_RS05985	COG0069	glutamate synthase activity
CV098_RS05985	COG0070	glutamate synthase
CV098_RS05990	COG0110	maltose O-acetyltransferase activity
CV098_RS05995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CV098_RS06000	COG0668	transmembrane transport
CV098_RS06005	COG0076	glutamate decarboxylase activity
CV098_RS06010	COG0531	amino acid
CV098_RS06020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CV098_RS06040	COG1349	DNA-binding transcription factor activity
CV098_RS06050	COG3443	Belongs to the bacterial solute-binding protein 9 family
CV098_RS06050	COG0803	Belongs to the bacterial solute-binding protein 9 family
CV098_RS06070	COG0406	alpha-ribazole phosphatase activity
CV098_RS06075	COG0561	phosphatase activity
CV098_RS06080	COG0561	phosphatase activity
CV098_RS06085	COG0110	maltose O-acetyltransferase activity
CV098_RS06090	COG0346	lactoylglutathione lyase activity
CV098_RS06100	COG3961	Belongs to the TPP enzyme family
CV098_RS06110	COG0583	DNA-binding transcription factor activity
CV098_RS06135	COG1393	Belongs to the ArsC family
CV098_RS06150	COG0803	Belongs to the bacterial solute-binding protein 9 family
CV098_RS06175	COG0419	ATPase involved in DNA repair
CV098_RS06185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CV098_RS06190	COG1393	Belongs to the ArsC family
CV098_RS06205	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CV098_RS06210	COG2226	methyltransferase
CV098_RS06215	COG3845	ABC transporter
CV098_RS06220	COG4603	Belongs to the binding-protein-dependent transport system permease family
CV098_RS06225	COG1079	Belongs to the binding-protein-dependent transport system permease family
CV098_RS06230	COG0039	L-malate dehydrogenase activity
CV098_RS06235	COG0469	pyruvate kinase activity
CV098_RS06240	COG0205	6-phosphofructokinase activity
CV098_RS06255	COG3853	Toxic anion resistance protein (TelA)
CV098_RS06265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CV098_RS06285	COG0142	geranyltranstransferase activity
CV098_RS06290	COG0357	Ribosomal RNA small subunit methyltransferase G
CV098_RS06300	COG0284	orotidine-5'-phosphate decarboxylase activity
CV098_RS06305	COG0167	dihydroorotate dehydrogenase activity
CV098_RS06310	COG0543	2 iron, 2 sulfur cluster binding
CV098_RS06315	COG2814	Major facilitator Superfamily
CV098_RS06320	COG2188	Transcriptional regulator
CV098_RS06325	COG2723	6-phospho-beta-galactosidase activity
CV098_RS06340	COG1175	transmembrane transport
CV098_RS06380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CV098_RS06385	COG0386	Belongs to the glutathione peroxidase family
CV098_RS06390	COG1705	Flagellar rod assembly protein muramidase FlgJ
CV098_RS06395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS06435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CV098_RS06470	COG0463	Glycosyl transferase, family 2
CV098_RS06565	COG0740	serine-type endopeptidase activity
CV098_RS06645	COG4806	L-rhamnose isomerase
CV098_RS06655	COG3723	Recombinational DNA repair protein, rece pathway
CV098_RS06700	COG0582	viral genome integration into host DNA
CV098_RS06710	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CV098_RS06715	COG0745	RESPONSE REGULATOR receiver
CV098_RS06730	COG2188	Transcriptional regulator
CV098_RS06735	COG1744	ABC transporter substrate-binding protein PnrA-like
CV098_RS06745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CV098_RS06760	COG2813	Specifically methylates the guanine in position
CV098_RS06765	COG1072	(Pantothenic acid kinase))
CV098_RS06770	COG3223	Belongs to the PsiE family
CV098_RS06785	COG1475	DNA binding
CV098_RS06790	COG3969	phosphoadenosine phosphosulfate
CV098_RS06810	COG3448	diguanylate cyclase activity
CV098_RS06810	COG4175	Glycine betaine
CV098_RS06820	COG0438	transferase activity, transferring glycosyl groups
CV098_RS06835	COG0463	Glycosyl transferase, family 2
CV098_RS06850	COG2723	6-phospho-beta-galactosidase activity
CV098_RS06855	COG1263	PTS System
CV098_RS06855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CV098_RS06855	COG2190	(PTS) system
CV098_RS06865	COG0159	tryptophan synthase activity
CV098_RS06870	COG0133	tryptophan synthase activity
CV098_RS06880	COG0135	phosphoribosylanthranilate isomerase activity
CV098_RS06885	COG0134	indole-3-glycerol-phosphate synthase activity
CV098_RS06890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CV098_RS06895	COG0512	Glutamine amidotransferase of anthranilate synthase
CV098_RS06900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CV098_RS06905	COG3759	membrane
CV098_RS06910	COG0778	Nitroreductase
CV098_RS06935	COG0735	belongs to the Fur family
CV098_RS06945	COG0697	spore germination
CV098_RS06950	COG0789	Transcriptional regulator
CV098_RS06955	COG4221	oxidoreductase activity
CV098_RS06960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CV098_RS06985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CV098_RS06985	COG0519	Catalyzes the synthesis of GMP from XMP
CV098_RS07000	COG2723	6-phospho-beta-galactosidase activity
CV098_RS07015	COG0366	Alpha amylase catalytic
CV098_RS07025	COG1653	transport
CV098_RS07030	COG0395	ABC-type sugar transport system, permease component
CV098_RS07035	COG1175	transmembrane transport
CV098_RS07040	COG0383	alpha-mannosidase activity
CV098_RS07060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CV098_RS07075	COG3507	Belongs to the glycosyl hydrolase 43 family
CV098_RS07080	COG2211	Major facilitator Superfamily
CV098_RS07090	COG1070	Carbohydrate kinase
CV098_RS07095	COG2115	Belongs to the xylose isomerase family
CV098_RS07110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CV098_RS07115	COG0151	Belongs to the GarS family
CV098_RS07125	COG2814	Major facilitator Superfamily
CV098_RS07130	COG1011	Hydrolase
CV098_RS07135	COG0138	bifunctional purine biosynthesis protein purh
CV098_RS07155	COG1132	(ABC) transporter
CV098_RS07160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CV098_RS07165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CV098_RS07170	COG0542	response to heat
CV098_RS07190	COG4221	oxidoreductase activity
CV098_RS07195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CV098_RS07200	COG0047	phosphoribosylformylglycinamidine synthase activity
CV098_RS07210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CV098_RS07225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CV098_RS07235	COG4221	oxidoreductase activity
CV098_RS07240	COG0477	Major facilitator Superfamily
CV098_RS07245	COG1846	Transcriptional regulator
CV098_RS07250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CV098_RS07270	COG1063	alcohol dehydrogenase
CV098_RS07285	COG0167	dihydroorotate dehydrogenase activity
CV098_RS07290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CV098_RS07295	COG0673	inositol 2-dehydrogenase activity
CV098_RS07305	COG0488	(ABC) transporter
CV098_RS07315	COG0583	DNA-binding transcription factor activity
CV098_RS07320	COG0371	Dehydrogenase
CV098_RS07330	COG4690	dipeptidase activity
CV098_RS07335	COG0617	tRNA 3'-terminal CCA addition
CV098_RS07345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CV098_RS07360	COG0336	Belongs to the RNA methyltransferase TrmD family
CV098_RS07365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CV098_RS07370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CV098_RS07390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CV098_RS07395	COG1837	Belongs to the UPF0109 family
CV098_RS07400	COG0228	four-way junction DNA binding
CV098_RS07410	COG0183	Belongs to the thiolase family
CV098_RS07415	COG3425	synthase
CV098_RS07420	COG0363	glucosamine-6-phosphate deaminase activity
CV098_RS07435	COG0110	maltose O-acetyltransferase activity
CV098_RS07455	COG1073	alpha beta
CV098_RS07470	COG0653	protein targeting
CV098_RS07485	COG0438	transferase activity, transferring glycosyl groups
CV098_RS07535	COG4974	Belongs to the 'phage' integrase family
CV098_RS07540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CV098_RS07595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CV098_RS07605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CV098_RS07610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CV098_RS07615	COG0347	Belongs to the P(II) protein family
CV098_RS07620	COG0004	ammonium transporteR
CV098_RS07625	COG5002	protein histidine kinase activity
CV098_RS07630	COG0745	RESPONSE REGULATOR receiver
CV098_RS07635	COG1399	metal-binding, possibly nucleic acid-binding protein
CV098_RS07640	COG0254	rRNA binding
CV098_RS07665	COG1408	metallophosphoesterase
CV098_RS07700	COG0589	response to stress
CV098_RS07715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CV098_RS07755	COG0505	Belongs to the CarA family
CV098_RS07760	COG0540	Belongs to the ATCase OTCase family
CV098_RS07770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CV098_RS07785	COG1230	cation diffusion facilitator family transporter
CV098_RS07790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CV098_RS07795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CV098_RS07830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CV098_RS07845	COG1285	pathogenesis
CV098_RS07850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CV098_RS07860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CV098_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CV098_RS07895	COG0800	Aldolase
CV098_RS07900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CV098_RS07905	COG1904	glucuronate isomerase
CV098_RS07920	COG1312	Catalyzes the dehydration of D-mannonate
CV098_RS07925	COG0246	Mannitol dehydrogenase
CV098_RS07930	COG1802	Transcriptional regulator
CV098_RS07935	COG0477	Major facilitator Superfamily
CV098_RS07940	COG1879	ABC-type sugar transport system periplasmic component
CV098_RS07945	COG1172	Belongs to the binding-protein-dependent transport system permease family
CV098_RS07950	COG1129	ABC transporter
CV098_RS07955	COG1869	D-ribose catabolic process
CV098_RS07960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CV098_RS07965	COG1609	Transcriptional regulator
CV098_RS07970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CV098_RS07975	COG0710	3-dehydroquinate dehydratase activity
CV098_RS07990	COG3118	belongs to the thioredoxin family
CV098_RS07995	COG1193	negative regulation of DNA recombination
CV098_RS08005	COG0492	ferredoxin-NADP+ reductase activity
CV098_RS08010	COG1609	Transcriptional regulator
CV098_RS08015	COG0006	proline dipeptidase activity
CV098_RS08025	COG0116	Belongs to the methyltransferase superfamily
CV098_RS08035	COG3599	regulation of cell shape
CV098_RS08040	COG1466	dna polymerase III delta subunit
CV098_RS08050	COG1674	ftsk spoiiie
CV098_RS08055	COG0561	phosphatase activity
CV098_RS08065	COG0280	phosphate acetyltransferase
CV098_RS08070	COG0572	uridine kinase
CV098_RS08075	COG0673	inositol 2-dehydrogenase activity
CV098_RS08085	COG0741	lytic transglycosylase activity
CV098_RS08130	COG2723	6-phospho-beta-galactosidase activity
CV098_RS08135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CV098_RS08140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CV098_RS08145	COG5002	protein histidine kinase activity
CV098_RS08150	COG0745	RESPONSE REGULATOR receiver
CV098_RS08155	COG1609	Transcriptional regulator
CV098_RS08165	COG0366	Alpha amylase catalytic
CV098_RS08175	COG0110	maltose O-acetyltransferase activity
CV098_RS08180	COG0366	Alpha amylase catalytic
CV098_RS08185	COG0366	Alpha amylase catalytic
CV098_RS08195	COG1175	transmembrane transport
CV098_RS08200	COG3833	ABC-type maltose transport systems, permease component
CV098_RS08230	COG0640	Transcriptional regulator
CV098_RS08235	COG1902	pentaerythritol trinitrate reductase activity
CV098_RS08260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CV098_RS08270	COG2957	Belongs to the agmatine deiminase family
CV098_RS08275	COG0531	amino acid
CV098_RS08280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CV098_RS08285	COG2197	response regulator
CV098_RS08295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CV098_RS08315	COG3715	PTS system
CV098_RS08320	COG3716	PTS system mannose fructose sorbose family IID component
CV098_RS08340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CV098_RS08345	COG1619	proteins homologs of microcin C7 resistance protein MccF
CV098_RS08355	COG0704	Plays a role in the regulation of phosphate uptake
CV098_RS08360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CV098_RS08365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CV098_RS08370	COG0581	inorganic phosphate transmembrane transporter activity
CV098_RS08375	COG0573	inorganic phosphate transmembrane transporter activity
CV098_RS08390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CV098_RS08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CV098_RS08405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CV098_RS08410	COG4122	O-methyltransferase activity
CV098_RS08415	COG1164	Oligoendopeptidase f
CV098_RS08435	COG2252	PERMEase
CV098_RS08440	COG0561	phosphatase activity
CV098_RS08445	COG0247	lactate metabolic process
CV098_RS08450	COG1139	Iron-sulfur cluster binding protein
CV098_RS08455	COG1556	Lactate utilization protein
CV098_RS08460	COG0670	Belongs to the BI1 family
CV098_RS08475	COG0268	Binds directly to 16S ribosomal RNA
CV098_RS08480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CV098_RS08485	COG0406	alpha-ribazole phosphatase activity
CV098_RS08490	COG0077	Prephenate dehydratase
CV098_RS08495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CV098_RS08500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CV098_RS08505	COG0287	Prephenate dehydrogenase
CV098_RS08510	COG5002	protein histidine kinase activity
CV098_RS08515	COG0745	RESPONSE REGULATOR receiver
CV098_RS08525	COG0577	efflux transmembrane transporter activity
CV098_RS08530	COG1136	(ABC) transporter
CV098_RS08540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CV098_RS08555	COG4493	Belongs to the UPF0637 family
CV098_RS08565	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CV098_RS08570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CV098_RS08580	COG0765	amino acid transport
CV098_RS08585	COG1126	abc transporter atp-binding protein
CV098_RS08600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CV098_RS08605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CV098_RS08610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CV098_RS08615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CV098_RS08620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CV098_RS08625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CV098_RS08630	COG0356	it plays a direct role in the translocation of protons across the membrane
CV098_RS08645	COG2333	competence protein COMEC
CV098_RS08645	COG0658	competence protein
CV098_RS08650	COG1596	polysaccharide export
CV098_RS08650	COG1555	photosystem II stabilization
CV098_RS08660	COG4152	abc transporter atp-binding protein
CV098_RS08680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CV098_RS08690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CV098_RS08690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CV098_RS08695	COG1268	BioY protein
CV098_RS08700	COG0318	PFAM AMP-dependent synthetase and ligase
CV098_RS08705	COG0183	Belongs to the thiolase family
CV098_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
CV098_RS08730	COG0719	Fe-S assembly protein
CV098_RS08745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CV098_RS08750	COG0719	Fe-S assembly protein
CV098_RS08760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CV098_RS08765	COG4862	establishment of competence for transformation
CV098_RS08770	COG1126	abc transporter atp-binding protein
CV098_RS08775	COG0765	amino acid transport
CV098_RS08785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CV098_RS08790	COG0085	RNA polymerase activity
CV098_RS08800	COG1396	sequence-specific DNA binding
CV098_RS08805	COG3590	peptidase
CV098_RS08815	COG2244	polysaccharide biosynthetic process
CV098_RS08820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CV098_RS08830	COG1064	alcohol dehydrogenase
CV098_RS08835	COG0514	ATP-dependent DNA helicase (RecQ)
CV098_RS08855	COG1227	inorganic diphosphatase activity
CV098_RS08860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CV098_RS08865	COG1253	flavin adenine dinucleotide binding
CV098_RS08870	COG0628	permease
CV098_RS08880	COG1573	uracil-dna glycosylase
CV098_RS08885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CV098_RS08895	COG2062	phosphohistidine phosphatase, SixA
CV098_RS08900	COG2827	Endonuclease containing a URI domain
CV098_RS08905	COG1113	amino acid transport
CV098_RS08915	COG1564	THIamine pyrophosphokinase
CV098_RS08935	COG0017	Asparaginyl-tRNA synthetase
CV098_RS08945	COG0436	Aminotransferase
CV098_RS08955	COG1199	ATP-dependent helicase activity
CV098_RS08955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CV098_RS08965	COG1253	flavin adenine dinucleotide binding
CV098_RS08975	COG2365	Tyrosine phosphatase family
CV098_RS08980	COG0747	negative chemotaxis
CV098_RS08990	COG0601	transmembrane transport
CV098_RS08995	COG4608	Belongs to the ABC transporter superfamily
CV098_RS09005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CV098_RS09010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CV098_RS09015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CV098_RS09030	COG0445	tRNA wobble uridine modification
CV098_RS09045	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CV098_RS09050	COG0215	cysteine-tRNA ligase activity
CV098_RS09060	COG1045	serine acetyltransferase
CV098_RS09070	COG1185	polyribonucleotide nucleotidyltransferase activity
CV098_RS09080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CV098_RS09085	COG0589	response to stress
CV098_RS09090	COG1104	cysteine desulfurase activity
CV098_RS09100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CV098_RS09115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CV098_RS09120	COG3599	regulation of cell shape
CV098_RS09135	COG1799	cell septum assembly
CV098_RS09140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CV098_RS09145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CV098_RS09150	COG0849	cell division
CV098_RS09155	COG1307	EDD domain protein, DegV family
CV098_RS09165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CV098_RS09170	COG0656	L-ascorbic acid biosynthetic process
CV098_RS09180	COG0583	DNA-binding transcription factor activity
CV098_RS09190	COG3579	cysteine-type endopeptidase activity
CV098_RS09200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CV098_RS09210	COG0494	nUDIX hydrolase
CV098_RS09215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CV098_RS09220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CV098_RS09225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CV098_RS09230	COG0515	serine threonine protein kinase
CV098_RS09230	COG2815	serine threonine protein kinase
CV098_RS09235	COG0631	protein serine/threonine phosphatase activity
CV098_RS09240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CV098_RS09240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CV098_RS09270	COG1247	-acetyltransferase
CV098_RS09280	COG1388	LysM domain
CV098_RS09280	COG3942	CHAP domain
CV098_RS09505	COG4974	Belongs to the 'phage' integrase family
CV098_RS09525	COG2261	transglycosylase associated protein
CV098_RS09535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CV098_RS09555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CV098_RS09560	COG1758	RNA polymerase activity
CV098_RS09565	COG0194	GDP metabolic process
CV098_RS09570	COG1418	mRNA catabolic process
CV098_RS09575	COG0363	glucosamine-6-phosphate deaminase activity
CV098_RS09580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CV098_RS09585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CV098_RS09590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CV098_RS09595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CV098_RS09595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CV098_RS09615	COG1705	Flagellar rod assembly protein muramidase FlgJ
CV098_RS09615	COG3942	CHAP domain
CV098_RS09650	COG1674	ftsk spoiiie
CV098_RS09670	COG0582	viral genome integration into host DNA
CV098_RS09675	COG0191	fructose-bisphosphate aldolase activity
CV098_RS09735	COG2860	membrane
CV098_RS09740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CV098_RS09760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CV098_RS09770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CV098_RS09775	COG0626	cystathionine gamma-synthase activity
CV098_RS09780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CV098_RS09800	COG3481	metal-dependent phosphohydrolase, HD sub domain
CV098_RS09810	COG1660	Displays ATPase and GTPase activities
CV098_RS09830	COG1162	GTPase activity
CV098_RS09835	COG3584	3D domain protein
CV098_RS09835	COG1388	LysM domain
CV098_RS09840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV098_RS09840	COG0072	phenylalanine-tRNA ligase activity
CV098_RS09845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CV098_RS09850	COG3479	Phenolic acid decarboxylase
CV098_RS09860	COG3469	chitinase activity
CV098_RS09865	COG3397	chitin binding
CV098_RS09870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CV098_RS09910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CV098_RS09915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CV098_RS09920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CV098_RS09930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CV098_RS09935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CV098_RS09940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CV098_RS09945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CV098_RS09950	COG0537	adenosine 5'-monophosphoramidase activity
CV098_RS09955	COG0124	histidyl-tRNA synthetase
CV098_RS09975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CV098_RS09980	COG1426	Protein conserved in bacteria
CV098_RS09985	COG0612	Peptidase, M16
CV098_RS09990	COG0612	Peptidase, M16
CV098_RS09995	COG2501	S4 domain
CV098_RS10000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CV098_RS10005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CV098_RS10010	COG4978	Transcriptional regulator
CV098_RS10010	COG0789	Transcriptional regulator
CV098_RS10020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CV098_RS10025	COG3250	beta-galactosidase activity
CV098_RS10030	COG0110	maltose O-acetyltransferase activity
CV098_RS10035	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CV098_RS10040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CV098_RS10060	COG0667	Aldo Keto reductase
CV098_RS10075	COG0826	peptidase U32
CV098_RS10095	COG0500	methyltransferase
CV098_RS10110	COG1131	(ABC) transporter
CV098_RS10115	COG0584	glycerophosphoryl diester phosphodiesterase
CV098_RS10120	COG0537	adenosine 5'-monophosphoramidase activity
CV098_RS10135	COG0081	regulation of translation
CV098_RS10140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CV098_RS10150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CV098_RS10155	COG4479	Belongs to the UPF0346 family
CV098_RS10160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CV098_RS10165	COG2996	Protein conserved in bacteria
CV098_RS10175	COG0233	cytoplasmic translational termination
CV098_RS10190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CV098_RS10195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CV098_RS10200	COG0827	DNA restriction-modification system
CV098_RS10210	COG1217	gtp-binding protein TYPA
CV098_RS10220	COG0577	efflux transmembrane transporter activity
CV098_RS10220	COG1136	(ABC) transporter
CV098_RS10245	COG1940	carbohydrate kinase activity
CV098_RS10255	COG0783	Belongs to the Dps family
CV098_RS10265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CV098_RS10275	COG0531	amino acid
CV098_RS10280	COG0436	Aminotransferase
CV098_RS10295	COG0531	amino acid
CV098_RS10300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CV098_RS10305	COG2235	arginine
CV098_RS10315	COG0018	arginyl-trna synthetase
CV098_RS10325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CV098_RS10360	COG3942	CHAP domain
CV098_RS10360	COG1705	Flagellar rod assembly protein muramidase FlgJ
CV098_RS10370	COG0433	COG0433 Predicted ATPase
CV098_RS10405	COG1396	sequence-specific DNA binding
CV098_RS10430	COG2946	Replication initiation factor
CV098_RS10435	COG1674	ftsk spoiiie
CV098_RS10490	COG0484	heat shock protein binding
CV098_RS10530	COG2261	transglycosylase associated protein
CV098_RS10540	COG1278	Cold shock
CV098_RS10560	COG0028	Belongs to the TPP enzyme family
CV098_RS10565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CV098_RS10575	COG1266	CAAX protease self-immunity
CV098_RS10580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CV098_RS10585	COG2936	dipeptidyl-peptidase activity
CV098_RS10590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CV098_RS10595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CV098_RS10600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CV098_RS10605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CV098_RS10645	COG4956	integral membrane protein (PIN domain superfamily)
CV098_RS10675	COG0203	ribosomal protein L17
CV098_RS10680	COG0202	RNA polymerase activity
CV098_RS10685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CV098_RS10690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CV098_RS10695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CV098_RS10700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CV098_RS10705	COG0563	adenylate kinase activity
CV098_RS10710	COG0201	protein transport
CV098_RS10715	COG0200	Binds to the 23S rRNA
CV098_RS10720	COG1841	ribosomal large subunit assembly
CV098_RS10725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CV098_RS10730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CV098_RS10735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CV098_RS10740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CV098_RS10750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CV098_RS10755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CV098_RS10760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CV098_RS10765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CV098_RS10770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CV098_RS10775	COG0255	Belongs to the universal ribosomal protein uL29 family
CV098_RS10780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CV098_RS10785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CV098_RS10790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CV098_RS10795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CV098_RS10800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CV098_RS10810	COG0088	Forms part of the polypeptide exit tunnel
CV098_RS10815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CV098_RS10820	COG0051	transcription antitermination factor activity, RNA binding
CV098_RS10825	COG1970	mechanosensitive ion channel activity
CV098_RS10835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CV098_RS10840	COG0250	Participates in transcription elongation, termination and antitermination
CV098_RS10850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CV098_RS10865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CV098_RS10870	COG1121	(ABC) transporter
CV098_RS10875	COG3443	Belongs to the bacterial solute-binding protein 9 family
CV098_RS10875	COG0803	Belongs to the bacterial solute-binding protein 9 family
CV098_RS10880	COG1846	Transcriptional regulator
CV098_RS10905	COG4537	Required for transformation and DNA binding
CV098_RS10910	COG1459	type II secretion system
CV098_RS10915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CV098_RS10920	COG2176	DNA-directed DNA polymerase activity
CV098_RS10930	COG0446	pyridine nucleotide-disulphide oxidoreductase
CV098_RS10935	COG0442	prolyl-tRNA aminoacylation
CV098_RS10940	COG0750	zinc metalloprotease
CV098_RS10945	COG4589	Belongs to the CDS family
CV098_RS10950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CV098_RS10955	COG1862	Preprotein translocase
CV098_RS10965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CV098_RS10970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CV098_RS10980	COG0438	transferase activity, transferring glycosyl groups
CV098_RS10995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CV098_RS11000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CV098_RS11000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CV098_RS11005	COG0561	phosphatase activity
CV098_RS11010	COG1609	Transcriptional regulator
CV098_RS11025	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CV098_RS11030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CV098_RS11035	COG0052	Belongs to the universal ribosomal protein uS2 family
CV098_RS11040	COG2706	6-phosphogluconolactonase activity
CV098_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
CV098_RS11045	COG1454	alcohol dehydrogenase
CV098_RS11070	COG1396	sequence-specific DNA binding
CV098_RS11075	COG3480	Lon protease (S16) C-terminal proteolytic domain
CV098_RS11080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CV098_RS11085	COG0742	ribosomal rna small subunit methyltransferase
CV098_RS11090	COG2814	Major facilitator Superfamily
CV098_RS11110	COG0166	Belongs to the GPI family
CV098_RS11120	COG0702	epimerase
CV098_RS11125	COG1733	regulation of RNA biosynthetic process
CV098_RS11130	COG0525	valine-tRNA ligase activity
CV098_RS11160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CV098_RS11175	COG2137	regulation of response to DNA damage stimulus
CV098_RS11205	COG1070	Carbohydrate kinase
CV098_RS11210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CV098_RS11225	COG1408	metallophosphoesterase
CV098_RS11230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CV098_RS11235	COG0629	single-stranded DNA binding
CV098_RS11240	COG0360	Binds together with S18 to 16S ribosomal RNA
CV098_RS11245	COG1968	undecaprenyl-diphosphatase activity
CV098_RS11250	COG0833	amino acid
CV098_RS11255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CV098_RS11265	COG1956	GAF domain-containing protein
CV098_RS11270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CV098_RS11270	COG1605	Chorismate mutase
CV098_RS11295	COG1376	ErfK ybiS ycfS ynhG family protein
CV098_RS11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CV098_RS11420	COG3759	membrane
CV098_RS11440	COG0174	glutamine synthetase
CV098_RS11445	COG0789	Transcriptional regulator
CV098_RS11450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CV098_RS11455	COG1131	(ABC) transporter
CV098_RS11475	COG2255	four-way junction helicase activity
CV098_RS11480	COG0632	four-way junction helicase activity
CV098_RS11485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CV098_RS11495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CV098_RS11505	COG2084	Dehydrogenase
CV098_RS11525	COG0730	response to heat
CV098_RS11535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CV098_RS11545	COG0484	heat shock protein binding
CV098_RS11565	COG0367	asparagine synthase
CV098_RS11570	COG3942	CHAP domain
CV098_RS11570	COG3883	PFAM NLP P60 protein
CV098_RS11585	COG0494	nUDIX hydrolase
CV098_RS11590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CV098_RS11595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CV098_RS11600	COG2814	Major facilitator Superfamily
CV098_RS11605	COG0589	response to stress
CV098_RS11620	COG1309	transcriptional regulator
CV098_RS11625	COG1187	pseudouridine synthase activity
CV098_RS11635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CV098_RS11645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CV098_RS11650	COG2824	Alkylphosphonate utilization operon protein PhnA
CV098_RS11670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CV098_RS11685	COG1266	CAAX protease self-immunity
CV098_RS11745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CV098_RS11750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CV098_RS11760	COG1136	(ABC) transporter
CV098_RS11765	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CV098_RS11770	COG0681	Belongs to the peptidase S26 family
CV098_RS11775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CV098_RS11780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CV098_RS11785	COG0049	tRNA binding
CV098_RS11790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CV098_RS11795	COG1686	Belongs to the peptidase S11 family
CV098_RS11800	COG4975	Glucose uptake
CV098_RS11805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CV098_RS11810	COG1242	4 iron, 4 sulfur cluster binding