locus-tag	class	description
NCDO2118_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NCDO2118_RS00010	COG0592	DNA-directed DNA polymerase activity
NCDO2118_RS00015	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NCDO2118_RS00020	COG1074	ATP-dependent DNA helicase activity
NCDO2118_RS00035	COG0012	GTP binding
NCDO2118_RS00055	COG0577	efflux transmembrane transporter activity
NCDO2118_RS00055	COG1136	(ABC) transporter
NCDO2118_RS00060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NCDO2118_RS00065	COG0193	aminoacyl-tRNA hydrolase activity
NCDO2118_RS00070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NCDO2118_RS00080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NCDO2118_RS00100	COG0037	tRNA processing
NCDO2118_RS00105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NCDO2118_RS00110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NCDO2118_RS00155	COG2213	PTS system mannitol-specific
NCDO2118_RS00165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS00170	COG0246	Mannitol dehydrogenase
NCDO2118_RS00190	COG0659	secondary active sulfate transmembrane transporter activity
NCDO2118_RS00205	COG0436	Aminotransferase
NCDO2118_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
NCDO2118_RS00235	COG0095	Lipoate-protein ligase
NCDO2118_RS00240	COG0584	glycerophosphoryl diester phosphodiesterase
NCDO2118_RS00245	COG1418	mRNA catabolic process
NCDO2118_RS00250	COG0180	Tryptophanyl-tRNA synthetase
NCDO2118_RS00255	COG1764	response to oxidative stress
NCDO2118_RS00270	COG0416	fatty acid biosynthetic process
NCDO2118_RS00280	COG0488	(ABC) transporter
NCDO2118_RS00305	COG4221	oxidoreductase activity
NCDO2118_RS00320	COG0400	carboxylic ester hydrolase activity
NCDO2118_RS00325	COG0346	lactoylglutathione lyase activity
NCDO2118_RS00330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NCDO2118_RS00335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NCDO2118_RS00340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NCDO2118_RS00345	COG2217	Heavy metal translocating P-type atpase
NCDO2118_RS00350	COG1475	DNA binding
NCDO2118_RS00355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NCDO2118_RS00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NCDO2118_RS00370	COG0488	(ABC) transporter
NCDO2118_RS00385	COG2264	protein methyltransferase activity
NCDO2118_RS00390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NCDO2118_RS00395	COG0726	polysaccharide deacetylase
NCDO2118_RS00405	COG0463	Glycosyl transferase, family 2
NCDO2118_RS00410	COG1490	D-aminoacyl-tRNA deacylase activity
NCDO2118_RS00420	COG1011	Hydrolase
NCDO2118_RS00425	COG0531	amino acid
NCDO2118_RS00430	COG0204	Acyl-transferase
NCDO2118_RS00440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NCDO2118_RS00445	COG0653	protein targeting
NCDO2118_RS00450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NCDO2118_RS00460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NCDO2118_RS00470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NCDO2118_RS00485	COG2076	Multidrug Resistance protein
NCDO2118_RS00490	COG2814	Major facilitator Superfamily
NCDO2118_RS00510	COG4555	ABC transporter
NCDO2118_RS00525	COG0469	pyruvate kinase activity
NCDO2118_RS00535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NCDO2118_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
NCDO2118_RS00545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NCDO2118_RS00550	COG0284	orotidine-5'-phosphate decarboxylase activity
NCDO2118_RS00575	COG0137	argininosuccinate synthase activity
NCDO2118_RS00580	COG0165	Argininosuccinate lyase
NCDO2118_RS00595	COG0594	ribonuclease P activity
NCDO2118_RS00600	COG0706	membrane insertase activity
NCDO2118_RS00610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NCDO2118_RS00615	COG4989	oxidoreductase activity
NCDO2118_RS00620	COG4472	Bacterial protein of unknown function (DUF965)
NCDO2118_RS00625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NCDO2118_RS00630	COG3906	Belongs to the UPF0473 family
NCDO2118_RS00640	COG0300	oxidoreductase activity
NCDO2118_RS00650	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NCDO2118_RS00655	COG1309	transcriptional regulator
NCDO2118_RS00660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NCDO2118_RS00690	COG0489	protein tyrosine kinase activity
NCDO2118_RS00695	COG4464	protein tyrosine phosphatase activity
NCDO2118_RS00700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NCDO2118_RS00715	COG1442	glycosyl transferase family 8
NCDO2118_RS00715	COG1216	Glycosyl transferase, family 2
NCDO2118_RS00730	COG2244	polysaccharide biosynthetic process
NCDO2118_RS00740	COG1316	TRANSCRIPTIONal
NCDO2118_RS00755	COG0343	queuine tRNA-ribosyltransferase activity
NCDO2118_RS00765	COG2814	Major facilitator Superfamily
NCDO2118_RS00770	COG1832	CoA-binding protein
NCDO2118_RS00795	COG0436	Aminotransferase
NCDO2118_RS00800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NCDO2118_RS00805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NCDO2118_RS00810	COG0154	amidase activity
NCDO2118_RS00815	COG1051	belongs to the nudix hydrolase family
NCDO2118_RS00820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NCDO2118_RS00840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NCDO2118_RS00865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NCDO2118_RS00880	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS00885	COG0756	dUTP diphosphatase activity
NCDO2118_RS00900	COG0737	Belongs to the 5'-nucleotidase family
NCDO2118_RS00905	COG4470	Protein conserved in bacteria
NCDO2118_RS00910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NCDO2118_RS00920	COG0142	geranyltranstransferase activity
NCDO2118_RS00950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NCDO2118_RS00955	COG1461	Dihydroxyacetone kinase
NCDO2118_RS00965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NCDO2118_RS00975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NCDO2118_RS00995	COG1088	dTDP-glucose 4,6-dehydratase activity
NCDO2118_RS01010	COG0463	Glycosyl transferase, family 2
NCDO2118_RS01030	COG1442	glycosyl transferase family 8
NCDO2118_RS01030	COG1216	Glycosyl transferase, family 2
NCDO2118_RS01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NCDO2118_RS01060	COG2244	polysaccharide biosynthetic process
NCDO2118_RS01065	COG0438	transferase activity, transferring glycosyl groups
NCDO2118_RS01070	COG3475	LICD family
NCDO2118_RS01075	COG1216	Glycosyl transferase, family 2
NCDO2118_RS01080	COG1216	Glycosyl transferase, family 2
NCDO2118_RS01080	COG1442	glycosyl transferase family 8
NCDO2118_RS01090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NCDO2118_RS01100	COG0517	IMP dehydrogenase activity
NCDO2118_RS01100	COG0516	GMP reductase activity
NCDO2118_RS01105	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NCDO2118_RS01115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NCDO2118_RS01120	COG1534	Rna-binding protein
NCDO2118_RS01130	COG1713	HD superfamily hydrolase involved in NAD metabolism
NCDO2118_RS01140	COG0799	negative regulation of ribosome biogenesis
NCDO2118_RS01145	COG2226	methyltransferase
NCDO2118_RS01150	COG1323	Belongs to the UPF0348 family
NCDO2118_RS01160	COG0217	transcriptional regulatory protein
NCDO2118_RS01170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NCDO2118_RS01180	COG1309	transcriptional regulator
NCDO2118_RS01190	COG0789	Transcriptional regulator
NCDO2118_RS01195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NCDO2118_RS01230	COG0561	phosphatase activity
NCDO2118_RS01240	COG2376	Dihydroxyacetone kinase
NCDO2118_RS01245	COG1309	transcriptional regulator
NCDO2118_RS01250	COG2376	Dihydroxyacetone kinase
NCDO2118_RS01255	COG1461	Dihydroxyacetone kinase
NCDO2118_RS01260	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NCDO2118_RS01265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NCDO2118_RS01270	COG4690	dipeptidase activity
NCDO2118_RS01280	COG1131	(ABC) transporter
NCDO2118_RS01290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NCDO2118_RS01295	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NCDO2118_RS01305	COG2081	HI0933 family
NCDO2118_RS01310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NCDO2118_RS01335	COG1132	(ABC) transporter
NCDO2118_RS01345	COG0673	inositol 2-dehydrogenase activity
NCDO2118_RS01350	COG1854	S-ribosylhomocysteine lyase activity
NCDO2118_RS01360	COG0656	L-ascorbic acid biosynthetic process
NCDO2118_RS01365	COG1335	isochorismatase
NCDO2118_RS01380	COG1388	LysM domain
NCDO2118_RS01380	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS01385	COG1328	CTP reductase activity
NCDO2118_RS01400	COG0148	phosphopyruvate hydratase activity
NCDO2118_RS01415	COG1278	Cold shock
NCDO2118_RS01425	COG2261	transglycosylase associated protein
NCDO2118_RS01465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NCDO2118_RS01475	COG1215	transferase activity, transferring glycosyl groups
NCDO2118_RS01505	COG1131	(ABC) transporter
NCDO2118_RS01520	COG1396	sequence-specific DNA binding
NCDO2118_RS01550	COG1674	ftsk spoiiie
NCDO2118_RS01565	COG2946	Replication initiation factor
NCDO2118_RS01595	COG3266	domain, Protein
NCDO2118_RS01595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NCDO2118_RS01645	COG0582	viral genome integration into host DNA
NCDO2118_RS01665	COG1122	ATPase activity
NCDO2118_RS01670	COG1122	ATPase activity
NCDO2118_RS01675	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NCDO2118_RS01685	COG2171	N-acyltransferase activity
NCDO2118_RS01690	COG1473	amidohydrolase
NCDO2118_RS01695	COG0726	polysaccharide deacetylase
NCDO2118_RS01710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NCDO2118_RS01715	COG2183	response to ionizing radiation
NCDO2118_RS01720	COG3091	SprT-like family
NCDO2118_RS01725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NCDO2118_RS01740	COG5503	Protein of unknown function (DUF1447)
NCDO2118_RS01755	COG0456	acetyltransferase
NCDO2118_RS01760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NCDO2118_RS01785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NCDO2118_RS01795	COG3639	organic phosphonate transmembrane transporter activity
NCDO2118_RS01800	COG0737	Belongs to the 5'-nucleotidase family
NCDO2118_RS01805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NCDO2118_RS01810	COG0308	aminopeptidase N
NCDO2118_RS01820	COG1846	Transcriptional regulator
NCDO2118_RS01825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NCDO2118_RS01845	COG1132	(ABC) transporter
NCDO2118_RS01850	COG1132	(ABC) transporter
NCDO2118_RS01855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NCDO2118_RS01860	COG4443	Transcriptional Coactivator p15 (PC4)
NCDO2118_RS01865	COG1396	sequence-specific DNA binding
NCDO2118_RS01885	COG1268	BioY protein
NCDO2118_RS01890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NCDO2118_RS01895	COG3859	Proton-coupled thiamine transporter YuaJ
NCDO2118_RS01900	COG1464	Belongs to the NlpA lipoprotein family
NCDO2118_RS01910	COG1464	Belongs to the NlpA lipoprotein family
NCDO2118_RS01920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NCDO2118_RS01925	COG2011	ABC-type metal ion transport system permease component
NCDO2118_RS01930	COG4720	Psort location CytoplasmicMembrane, score
NCDO2118_RS01935	COG1122	ATPase activity
NCDO2118_RS01950	COG1120	ATPase activity
NCDO2118_RS01955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCDO2118_RS01960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCDO2118_RS01965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCDO2118_RS01975	COG2814	Major facilitator Superfamily
NCDO2118_RS01980	COG0656	L-ascorbic acid biosynthetic process
NCDO2118_RS01985	COG1733	regulation of RNA biosynthetic process
NCDO2118_RS01990	COG0346	lactoylglutathione lyase activity
NCDO2118_RS01995	COG0588	phosphoglycerate mutase activity
NCDO2118_RS02000	COG0450	alkyl hydroperoxide reductase
NCDO2118_RS02005	COG3634	alkyl hydroperoxide reductase activity
NCDO2118_RS02010	COG0768	penicillin binding
NCDO2118_RS02015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NCDO2118_RS02020	COG1181	Belongs to the D-alanine--D-alanine ligase family
NCDO2118_RS02025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NCDO2118_RS02030	COG4166	transmembrane transport
NCDO2118_RS02035	COG4166	transmembrane transport
NCDO2118_RS02040	COG0601	transmembrane transport
NCDO2118_RS02045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NCDO2118_RS02050	COG0444	Belongs to the ABC transporter superfamily
NCDO2118_RS02055	COG4608	Belongs to the ABC transporter superfamily
NCDO2118_RS02060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NCDO2118_RS02065	COG0513	Belongs to the DEAD box helicase family
NCDO2118_RS02070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NCDO2118_RS02075	COG0367	asparagine synthase
NCDO2118_RS02080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NCDO2118_RS02085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NCDO2118_RS02090	COG1113	amino acid transport
NCDO2118_RS02095	COG1113	amino acid transport
NCDO2118_RS02105	COG4471	UPF0298 protein
NCDO2118_RS02125	COG2357	RelA SpoT domain protein
NCDO2118_RS02130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NCDO2118_RS02135	COG0564	pseudouridine synthase activity
NCDO2118_RS02145	COG0833	amino acid
NCDO2118_RS02160	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NCDO2118_RS02165	COG0583	DNA-binding transcription factor activity
NCDO2118_RS02170	COG2855	membrane
NCDO2118_RS02175	COG0039	L-malate dehydrogenase activity
NCDO2118_RS02180	COG0583	DNA-binding transcription factor activity
NCDO2118_RS02190	COG0301	tRNA thio-modification
NCDO2118_RS02195	COG2814	Major facilitator Superfamily
NCDO2118_RS02200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NCDO2118_RS02205	COG1764	response to oxidative stress
NCDO2118_RS02210	COG0025	NhaP-type Na H and K H
NCDO2118_RS02220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NCDO2118_RS02230	COG1363	Peptidase, m42
NCDO2118_RS02240	COG3118	belongs to the thioredoxin family
NCDO2118_RS02245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCDO2118_RS02250	COG0446	pyridine nucleotide-disulphide oxidoreductase
NCDO2118_RS02260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NCDO2118_RS02265	COG0459	protein refolding
NCDO2118_RS02270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NCDO2118_RS02275	COG5002	protein histidine kinase activity
NCDO2118_RS02280	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS02285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NCDO2118_RS02290	COG0470	DNA polymerase III
NCDO2118_RS02295	COG1774	PSP1 C-terminal conserved region
NCDO2118_RS02315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NCDO2118_RS02330	COG1304	FMN binding
NCDO2118_RS02335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NCDO2118_RS02340	COG1966	Carbon starvation protein
NCDO2118_RS02345	COG0513	Belongs to the DEAD box helicase family
NCDO2118_RS02355	COG1737	Transcriptional regulator
NCDO2118_RS02360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NCDO2118_RS02365	COG1447	Phosphotransferase system cellobiose-specific component IIA
NCDO2118_RS02370	COG1737	Transcriptional regulator
NCDO2118_RS02375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NCDO2118_RS02380	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS02395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NCDO2118_RS02400	COG1597	lipid kinase activity
NCDO2118_RS02405	COG3842	ATPase activity
NCDO2118_RS02425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NCDO2118_RS02430	COG2188	Transcriptional regulator
NCDO2118_RS02435	COG2190	(PTS) system
NCDO2118_RS02435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS02435	COG1263	PTS System
NCDO2118_RS02440	COG1263	PTS System
NCDO2118_RS02440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS02445	COG1554	hydrolase, family 65, central catalytic
NCDO2118_RS02450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NCDO2118_RS02455	COG2755	lipolytic protein G-D-S-L family
NCDO2118_RS02455	COG0657	acetylesterase activity
NCDO2118_RS02470	COG0802	atpase or kinase
NCDO2118_RS02480	COG1316	TRANSCRIPTIONal
NCDO2118_RS02490	COG0101	tRNA pseudouridine synthase activity
NCDO2118_RS02495	COG0351	phosphomethylpyrimidine kinase
NCDO2118_RS02500	COG4720	Psort location CytoplasmicMembrane, score
NCDO2118_RS02505	COG4475	Protein of unknown function (DUF436)
NCDO2118_RS02510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NCDO2118_RS02515	COG0504	CTP synthase activity
NCDO2118_RS02540	COG1611	Belongs to the LOG family
NCDO2118_RS02545	COG1428	Deoxynucleoside kinase
NCDO2118_RS02550	COG0587	DNA-directed DNA polymerase activity
NCDO2118_RS02555	COG1272	protein, Hemolysin III
NCDO2118_RS02560	COG1307	EDD domain protein, DegV family
NCDO2118_RS02565	COG2755	lipolytic protein G-D-S-L family
NCDO2118_RS02580	COG0776	regulation of translation
NCDO2118_RS02590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NCDO2118_RS02595	COG2169	Transcriptional regulator
NCDO2118_RS02620	COG1104	cysteine desulfurase activity
NCDO2118_RS02625	COG3883	PFAM NLP P60 protein
NCDO2118_RS02625	COG0791	NLP P60 protein
NCDO2118_RS02630	COG4166	transmembrane transport
NCDO2118_RS02640	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS02640	COG1388	LysM domain
NCDO2118_RS02655	COG3331	DNA recombination
NCDO2118_RS02660	COG4474	Belongs to the UPF0398 family
NCDO2118_RS02665	COG1393	Belongs to the ArsC family
NCDO2118_RS02670	COG4476	Belongs to the UPF0223 family
NCDO2118_RS02675	COG0483	inositol monophosphate 1-phosphatase activity
NCDO2118_RS02680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NCDO2118_RS02690	COG0544	peptidyl-prolyl cis-trans isomerase activity
NCDO2118_RS02785	COG0358	DNA primase activity
NCDO2118_RS02790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NCDO2118_RS02810	COG0542	response to heat
NCDO2118_RS02815	COG1959	2 iron, 2 sulfur cluster binding
NCDO2118_RS02820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NCDO2118_RS02825	COG0242	peptide deformylase activity
NCDO2118_RS02830	COG0494	nUDIX hydrolase
NCDO2118_RS02835	COG0556	nucleotide-excision repair
NCDO2118_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NCDO2118_RS02845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NCDO2118_RS02850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NCDO2118_RS02855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NCDO2118_RS02865	COG1131	(ABC) transporter
NCDO2118_RS02875	COG0706	membrane insertase activity
NCDO2118_RS02885	COG4684	Psort location CytoplasmicMembrane, score
NCDO2118_RS02890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NCDO2118_RS02900	COG1942	4-Oxalocrotonate Tautomerase
NCDO2118_RS02905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS02935	COG1461	Dihydroxyacetone kinase
NCDO2118_RS02970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NCDO2118_RS02990	COG1435	thymidine kinase activity
NCDO2118_RS03000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NCDO2118_RS03010	COG0778	Nitroreductase
NCDO2118_RS03015	COG2890	protein-(glutamine-N5) methyltransferase activity
NCDO2118_RS03025	COG0009	L-threonylcarbamoyladenylate synthase
NCDO2118_RS03030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NCDO2118_RS03035	COG0741	lytic transglycosylase activity
NCDO2118_RS03040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NCDO2118_RS03045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NCDO2118_RS03050	COG0560	Phosphoserine phosphatase
NCDO2118_RS03055	COG1254	Belongs to the acylphosphatase family
NCDO2118_RS03060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NCDO2118_RS03070	COG0716	FMN binding
NCDO2118_RS03075	COG0477	Major facilitator Superfamily
NCDO2118_RS03085	COG0024	Methionine aminopeptidase
NCDO2118_RS03095	COG2246	polysaccharide biosynthetic process
NCDO2118_RS03115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NCDO2118_RS03120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NCDO2118_RS03130	COG4980	gas vesicle protein
NCDO2118_RS03135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NCDO2118_RS03140	COG1002	Type II restriction enzyme, methylase subunits
NCDO2118_RS03155	COG1061	Type III restriction enzyme res subunit
NCDO2118_RS03160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NCDO2118_RS03205	COG3158	transport of potassium into the cell
NCDO2118_RS03210	COG3158	transport of potassium into the cell
NCDO2118_RS03220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NCDO2118_RS03250	COG1234	tRNA 3'-trailer cleavage
NCDO2118_RS03255	COG0300	oxidoreductase activity
NCDO2118_RS03260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NCDO2118_RS03260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NCDO2118_RS03265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NCDO2118_RS03270	COG3343	RNA polymerase activity
NCDO2118_RS03275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NCDO2118_RS03280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NCDO2118_RS03285	COG4463	regulation of RNA biosynthetic process
NCDO2118_RS03290	COG0542	response to heat
NCDO2118_RS03295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NCDO2118_RS03300	COG0148	phosphopyruvate hydratase activity
NCDO2118_RS03310	COG0577	efflux transmembrane transporter activity
NCDO2118_RS03320	COG0318	PFAM AMP-dependent synthetase and ligase
NCDO2118_RS03330	COG1882	Formate acetyltransferase
NCDO2118_RS03335	COG0237	dephospho-CoA kinase activity
NCDO2118_RS03340	COG2814	Major facilitator Superfamily
NCDO2118_RS03345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NCDO2118_RS03350	COG0772	Belongs to the SEDS family
NCDO2118_RS03355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NCDO2118_RS03360	COG0372	Belongs to the citrate synthase family
NCDO2118_RS03365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NCDO2118_RS03375	COG0740	serine-type endopeptidase activity
NCDO2118_RS03385	COG1393	Belongs to the ArsC family
NCDO2118_RS03395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS03400	COG1114	Component of the transport system for branched-chain amino acids
NCDO2118_RS03410	COG3592	Divergent 4Fe-4S mono-cluster
NCDO2118_RS03420	COG3706	GGDEF domain
NCDO2118_RS03480	COG3711	transcriptional antiterminator
NCDO2118_RS03485	COG1263	PTS System
NCDO2118_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS03485	COG2190	(PTS) system
NCDO2118_RS03490	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS03500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS03500	COG2190	(PTS) system
NCDO2118_RS03500	COG1263	PTS System
NCDO2118_RS03505	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS03535	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS03535	COG3942	CHAP domain
NCDO2118_RS03640	COG0084	hydrolase, TatD family'
NCDO2118_RS03645	COG2274	protein secretion by the type I secretion system
NCDO2118_RS03645	COG3271	cysteine-type peptidase activity
NCDO2118_RS03650	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NCDO2118_RS03655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NCDO2118_RS03660	COG0006	proline dipeptidase activity
NCDO2118_RS03665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NCDO2118_RS03675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NCDO2118_RS03680	COG1640	4-alpha-glucanotransferase
NCDO2118_RS03685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NCDO2118_RS03690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NCDO2118_RS03695	COG0297	glycogen (starch) synthase activity
NCDO2118_RS03700	COG0058	SHG alpha-glucan phosphorylase activity
NCDO2118_RS03710	COG3104	oligopeptide transport
NCDO2118_RS03715	COG1271	oxidase subunit
NCDO2118_RS03720	COG1294	oxidase, subunit
NCDO2118_RS03725	COG4988	ABC transporter
NCDO2118_RS03730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NCDO2118_RS03735	COG1846	Transcriptional regulator
NCDO2118_RS03750	COG1132	(ABC) transporter
NCDO2118_RS03760	COG0586	Pfam SNARE associated Golgi protein
NCDO2118_RS03785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NCDO2118_RS03790	COG1234	tRNA 3'-trailer cleavage
NCDO2118_RS03835	COG4948	Mandelate Racemase Muconate Lactonizing
NCDO2118_RS03840	COG0318	PFAM AMP-dependent synthetase and ligase
NCDO2118_RS03845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NCDO2118_RS03850	COG2267	carboxylic ester hydrolase activity
NCDO2118_RS03855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NCDO2118_RS03860	COG1169	isochorismate synthase
NCDO2118_RS03865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NCDO2118_RS03870	COG4109	DRTGG domain
NCDO2118_RS03875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NCDO2118_RS03880	COG0252	asparaginase activity
NCDO2118_RS03885	COG0561	phosphatase activity
NCDO2118_RS03895	COG2268	Band 7 protein
NCDO2118_RS03910	COG1846	Transcriptional regulator
NCDO2118_RS03915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NCDO2118_RS03925	COG0359	binds to the 23S rRNA
NCDO2118_RS03930	COG0305	Participates in initiation and elongation during chromosome replication
NCDO2118_RS03945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NCDO2118_RS03950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NCDO2118_RS03965	COG1484	DNA-dependent DNA replication
NCDO2118_RS03970	COG0778	Nitroreductase
NCDO2118_RS03980	COG1160	GTP binding
NCDO2118_RS04010	COG1346	cytolysis
NCDO2118_RS04020	COG0779	Required for maturation of 30S ribosomal subunits
NCDO2118_RS04025	COG0195	Participates in both transcription termination and antitermination
NCDO2118_RS04030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NCDO2118_RS04040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NCDO2118_RS04045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NCDO2118_RS04050	COG1482	cell wall glycoprotein biosynthetic process
NCDO2118_RS04060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NCDO2118_RS04065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NCDO2118_RS04070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NCDO2118_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
NCDO2118_RS04080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NCDO2118_RS04090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NCDO2118_RS04095	COG0439	Biotin carboxylase
NCDO2118_RS04100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NCDO2118_RS04110	COG0626	cystathionine gamma-synthase activity
NCDO2118_RS04115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NCDO2118_RS04125	COG1054	Belongs to the UPF0176 family
NCDO2118_RS04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NCDO2118_RS04135	COG0446	pyridine nucleotide-disulphide oxidoreductase
NCDO2118_RS04145	COG1393	Belongs to the ArsC family
NCDO2118_RS04150	COG1349	DNA-binding transcription factor activity
NCDO2118_RS04160	COG0708	Exodeoxyribonuclease III
NCDO2118_RS04165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCDO2118_RS04165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCDO2118_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
NCDO2118_RS04180	COG4708	membrane
NCDO2118_RS04185	COG2910	NAD(P)H-binding
NCDO2118_RS04190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NCDO2118_RS04195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NCDO2118_RS04200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NCDO2118_RS04205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NCDO2118_RS04210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NCDO2118_RS04215	COG0571	ribonuclease III activity
NCDO2118_RS04220	COG1196	nuclear chromosome segregation
NCDO2118_RS04225	COG1368	sulfuric ester hydrolase activity
NCDO2118_RS04245	COG1113	amino acid transport
NCDO2118_RS04250	COG0561	phosphatase activity
NCDO2118_RS04260	COG0552	protein localization to endoplasmic reticulum
NCDO2118_RS04265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NCDO2118_RS04275	COG0495	leucyl-tRNA aminoacylation
NCDO2118_RS04285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NCDO2118_RS04290	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS04305	COG1252	NADH dehydrogenase
NCDO2118_RS04310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NCDO2118_RS04315	COG1760	l-serine dehydratase
NCDO2118_RS04320	COG1760	l-serine dehydratase
NCDO2118_RS04325	COG3682	Transcriptional regulator
NCDO2118_RS04335	COG2217	Heavy metal translocating P-type atpase
NCDO2118_RS04350	COG0482	sulfurtransferase activity
NCDO2118_RS04355	COG0539	negative regulation of cytoplasmic translation
NCDO2118_RS04360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NCDO2118_RS04365	COG3201	nicotinamide mononucleotide transporter
NCDO2118_RS04370	COG0322	excinuclease ABC activity
NCDO2118_RS04385	COG0736	holo-[acyl-carrier-protein] synthase activity
NCDO2118_RS04390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NCDO2118_RS04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NCDO2118_RS04410	COG1174	glycine betaine transport
NCDO2118_RS04465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NCDO2118_RS04470	COG1570	exodeoxyribonuclease VII activity
NCDO2118_RS04475	COG1722	exodeoxyribonuclease VII activity
NCDO2118_RS04490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NCDO2118_RS04495	COG1438	arginine binding
NCDO2118_RS04500	COG0497	DNA recombination
NCDO2118_RS04525	COG0275	rRNA processing
NCDO2118_RS04535	COG0768	penicillin binding
NCDO2118_RS04540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NCDO2118_RS04550	COG0577	efflux transmembrane transporter activity
NCDO2118_RS04555	COG1136	(ABC) transporter
NCDO2118_RS04560	COG0583	DNA-binding transcription factor activity
NCDO2118_RS04565	COG2357	RelA SpoT domain protein
NCDO2118_RS04570	COG0335	large ribosomal subunit rRNA binding
NCDO2118_RS04580	COG1215	transferase activity, transferring glycosyl groups
NCDO2118_RS04595	COG0589	response to stress
NCDO2118_RS04600	COG0776	regulation of translation
NCDO2118_RS04610	COG1511	domain protein
NCDO2118_RS04615	COG2151	metal-sulfur cluster biosynthetic enzyme
NCDO2118_RS04620	COG1120	ATPase activity
NCDO2118_RS04625	COG2819	hydrolase of the alpha beta superfamily
NCDO2118_RS04630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCDO2118_RS04635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCDO2118_RS04640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCDO2118_RS04650	COG3883	PFAM NLP P60 protein
NCDO2118_RS04650	COG3942	CHAP domain
NCDO2118_RS04660	COG0772	Belongs to the SEDS family
NCDO2118_RS04665	COG1316	TRANSCRIPTIONal
NCDO2118_RS04670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NCDO2118_RS04680	COG4585	Histidine kinase
NCDO2118_RS04685	COG2197	response regulator
NCDO2118_RS04700	COG0539	negative regulation of cytoplasmic translation
NCDO2118_RS04710	COG0772	Belongs to the SEDS family
NCDO2118_RS04715	COG1063	alcohol dehydrogenase
NCDO2118_RS04725	COG0488	(ABC) transporter
NCDO2118_RS04730	COG0281	malic enzyme
NCDO2118_RS04755	COG0187	DNA topoisomerase II activity
NCDO2118_RS04765	COG0500	methyltransferase
NCDO2118_RS04780	COG2814	Major facilitator Superfamily
NCDO2118_RS04795	COG1388	LysM domain
NCDO2118_RS04795	COG1134	teichoic acid transport
NCDO2118_RS04800	COG1682	transport, permease protein
NCDO2118_RS04825	COG1215	transferase activity, transferring glycosyl groups
NCDO2118_RS04825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NCDO2118_RS04835	COG0562	UDP-galactopyranose mutase
NCDO2118_RS04855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NCDO2118_RS04875	COG1316	TRANSCRIPTIONal
NCDO2118_RS04880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NCDO2118_RS04890	COG0813	purine-nucleoside phosphorylase activity
NCDO2118_RS04895	COG0582	viral genome integration into host DNA
NCDO2118_RS04935	COG3561	AntA/AntB antirepressor
NCDO2118_RS04945	COG3620	sequence-specific DNA binding
NCDO2118_RS04955	COG3723	Recombinational DNA repair protein, rece pathway
NCDO2118_RS05015	COG0756	dUTP diphosphatase activity
NCDO2118_RS05185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCDO2118_RS05210	COG0393	Putative heavy-metal-binding
NCDO2118_RS05215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NCDO2118_RS05225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NCDO2118_RS05230	COG0765	amino acid transport
NCDO2118_RS05235	COG1126	abc transporter atp-binding protein
NCDO2118_RS05245	COG0492	ferredoxin-NADP+ reductase activity
NCDO2118_RS05255	COG0557	exoribonuclease II activity
NCDO2118_RS05275	COG3830	Belongs to the UPF0237 family
NCDO2118_RS05280	COG2848	UPF0210 protein
NCDO2118_RS05290	COG0588	phosphoglycerate mutase activity
NCDO2118_RS05305	COG1420	regulation of RNA biosynthetic process
NCDO2118_RS05310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NCDO2118_RS05315	COG0443	Heat shock 70 kDa protein
NCDO2118_RS05325	COG1473	amidohydrolase
NCDO2118_RS05330	COG1349	DNA-binding transcription factor activity
NCDO2118_RS05335	COG1105	Belongs to the carbohydrate kinase PfkB family
NCDO2118_RS05340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCDO2118_RS05340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS05340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCDO2118_RS05345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NCDO2118_RS05350	COG1660	Displays ATPase and GTPase activities
NCDO2118_RS05355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NCDO2118_RS05360	COG1481	regulation of sporulation
NCDO2118_RS05370	COG1131	(ABC) transporter
NCDO2118_RS05385	COG2116	formate transmembrane transporter activity
NCDO2118_RS05400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NCDO2118_RS05405	COG2884	Cell division ATP-binding protein ftsE
NCDO2118_RS05410	COG2177	Part of the ABC transporter FtsEX involved in
NCDO2118_RS05415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NCDO2118_RS05425	COG1780	Probably involved in ribonucleotide reductase function
NCDO2118_RS05430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NCDO2118_RS05435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NCDO2118_RS05440	COG0187	DNA topoisomerase II activity
NCDO2118_RS05450	COG2176	DNA-directed DNA polymerase activity
NCDO2118_RS05455	COG2153	protein acetylation
NCDO2118_RS05480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NCDO2118_RS05480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NCDO2118_RS05485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NCDO2118_RS05490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NCDO2118_RS05495	COG0564	pseudouridine synthase activity
NCDO2118_RS05500	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NCDO2118_RS05510	COG0463	Glycosyl transferase, family 2
NCDO2118_RS05515	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS05525	COG5002	protein histidine kinase activity
NCDO2118_RS05530	COG0671	phosphoesterase, PA-phosphatase related
NCDO2118_RS05535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NCDO2118_RS05540	COG2003	Belongs to the UPF0758 family
NCDO2118_RS05545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NCDO2118_RS05550	COG1393	Belongs to the ArsC family
NCDO2118_RS05555	COG0488	(ABC) transporter
NCDO2118_RS05585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NCDO2118_RS05590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NCDO2118_RS05600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NCDO2118_RS05605	COG2384	SAM-dependent methyltransferase
NCDO2118_RS05610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NCDO2118_RS05625	COG1078	dGTPase activity
NCDO2118_RS05640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NCDO2118_RS05650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NCDO2118_RS05655	COG1914	H( )-stimulated, divalent metal cation uptake system
NCDO2118_RS05660	COG1702	phosphate starvation-inducible protein PhoH
NCDO2118_RS05670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NCDO2118_RS05675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NCDO2118_RS05690	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NCDO2118_RS05695	COG1739	Uncharacterized protein family UPF0029
NCDO2118_RS05715	COG0752	glycyl-tRNA synthetase alpha subunit
NCDO2118_RS05720	COG0751	glycine-tRNA ligase activity
NCDO2118_RS05725	COG4224	UPF0291 protein
NCDO2118_RS05730	COG0038	chloride channel
NCDO2118_RS05735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NCDO2118_RS05745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NCDO2118_RS05755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NCDO2118_RS05760	COG1136	(ABC) transporter
NCDO2118_RS05770	COG3442	glutamine amidotransferase
NCDO2118_RS05775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NCDO2118_RS05780	COG3527	Alpha-acetolactate decarboxylase
NCDO2118_RS05785	COG0481	GTPase activity
NCDO2118_RS05790	COG0702	epimerase
NCDO2118_RS05795	COG0531	amino acid
NCDO2118_RS05810	COG3764	Sortase (surface protein transpeptidase)
NCDO2118_RS05820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NCDO2118_RS05820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NCDO2118_RS05835	COG0210	DNA helicase
NCDO2118_RS05840	COG2816	NAD+ diphosphatase activity
NCDO2118_RS05845	COG0519	Catalyzes the synthesis of GMP from XMP
NCDO2118_RS05865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NCDO2118_RS05870	COG0196	riboflavin kinase activity
NCDO2118_RS05875	COG0039	L-malate dehydrogenase activity
NCDO2118_RS05885	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NCDO2118_RS05890	COG1263	PTS System
NCDO2118_RS05890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS05895	COG1737	Transcriptional regulator
NCDO2118_RS05900	COG0149	triose-phosphate isomerase activity
NCDO2118_RS05915	COG3969	phosphoadenosine phosphosulfate
NCDO2118_RS05920	COG1475	DNA binding
NCDO2118_RS05925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NCDO2118_RS05955	COG0516	GMP reductase activity
NCDO2118_RS05960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NCDO2118_RS05965	COG2233	PERMEase
NCDO2118_RS05975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NCDO2118_RS05980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NCDO2118_RS05990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NCDO2118_RS05995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NCDO2118_RS06005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NCDO2118_RS06005	COG0302	gtp cyclohydrolase
NCDO2118_RS06010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NCDO2118_RS06015	COG1051	belongs to the nudix hydrolase family
NCDO2118_RS06020	COG0285	dihydrofolate synthase activity
NCDO2118_RS06025	COG1428	Deoxynucleoside kinase
NCDO2118_RS06030	COG0460	homoserine dehydrogenase
NCDO2118_RS06035	COG0083	homoserine kinase activity
NCDO2118_RS06045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NCDO2118_RS06050	COG3842	ATPase activity
NCDO2118_RS06055	COG1176	ABC-type spermidine putrescine transport system, permease component I
NCDO2118_RS06060	COG1177	transmembrane transport
NCDO2118_RS06105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NCDO2118_RS06110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS06115	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NCDO2118_RS06125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NCDO2118_RS06130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NCDO2118_RS06135	COG2226	methyltransferase
NCDO2118_RS06140	COG0628	permease
NCDO2118_RS06150	COG0028	Belongs to the TPP enzyme family
NCDO2118_RS06190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NCDO2118_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
NCDO2118_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
NCDO2118_RS06190	COG3321	synthase
NCDO2118_RS06190	COG0300	oxidoreductase activity
NCDO2118_RS06195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NCDO2118_RS06210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NCDO2118_RS06285	COG2205	protein histidine kinase activity
NCDO2118_RS06290	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS06295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NCDO2118_RS06300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NCDO2118_RS06305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NCDO2118_RS06320	COG0557	exoribonuclease II activity
NCDO2118_RS06325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NCDO2118_RS06330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NCDO2118_RS06335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NCDO2118_RS06340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NCDO2118_RS06350	COG0131	Imidazoleglycerol-phosphate dehydratase
NCDO2118_RS06355	COG3231	kanamycin kinase activity
NCDO2118_RS06360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NCDO2118_RS06365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NCDO2118_RS06370	COG0107	imidazoleglycerol-phosphate synthase activity
NCDO2118_RS06375	COG0140	phosphoribosyl-ATP diphosphatase activity
NCDO2118_RS06375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NCDO2118_RS06380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NCDO2118_RS06385	COG1054	Belongs to the UPF0176 family
NCDO2118_RS06395	COG0473	3-isopropylmalate dehydrogenase activity
NCDO2118_RS06405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NCDO2118_RS06410	COG0066	3-isopropylmalate dehydratase activity
NCDO2118_RS06415	COG1119	ATPase activity
NCDO2118_RS06420	COG0129	dihydroxy-acid dehydratase activity
NCDO2118_RS06425	COG0028	Belongs to the TPP enzyme family
NCDO2118_RS06430	COG0440	acetolactate synthase activity
NCDO2118_RS06435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NCDO2118_RS06440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NCDO2118_RS06445	COG3527	Alpha-acetolactate decarboxylase
NCDO2118_RS06450	COG0251	oxidation-reduction process
NCDO2118_RS06455	COG0758	DNA mediated transformation
NCDO2118_RS06460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NCDO2118_RS06465	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NCDO2118_RS06470	COG4974	Belongs to the 'phage' integrase family
NCDO2118_RS06505	COG1846	Transcriptional regulator
NCDO2118_RS06535	COG1131	(ABC) transporter
NCDO2118_RS06555	COG0318	PFAM AMP-dependent synthetase and ligase
NCDO2118_RS06560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NCDO2118_RS06580	COG1131	(ABC) transporter
NCDO2118_RS06620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NCDO2118_RS06625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NCDO2118_RS06630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NCDO2118_RS06645	COG0025	NhaP-type Na H and K H
NCDO2118_RS06650	COG0438	transferase activity, transferring glycosyl groups
NCDO2118_RS06650	COG4641	Protein conserved in bacteria
NCDO2118_RS06660	COG1304	FMN binding
NCDO2118_RS06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NCDO2118_RS06670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NCDO2118_RS06675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NCDO2118_RS06685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS06690	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NCDO2118_RS06695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NCDO2118_RS06700	COG1696	Membrane protein involved in D-alanine export
NCDO2118_RS06705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NCDO2118_RS06715	COG0352	thiamine-phosphate diphosphorylase activity
NCDO2118_RS06720	COG0351	phosphomethylpyrimidine kinase
NCDO2118_RS06725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NCDO2118_RS06735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NCDO2118_RS06745	COG0222	ribosome binding
NCDO2118_RS06750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NCDO2118_RS06760	COG3620	sequence-specific DNA binding
NCDO2118_RS06765	COG1132	(ABC) transporter
NCDO2118_RS06770	COG1132	(ABC) transporter
NCDO2118_RS06780	COG1187	pseudouridine synthase activity
NCDO2118_RS06785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NCDO2118_RS06790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NCDO2118_RS06795	COG4974	Belongs to the 'phage' integrase family
NCDO2118_RS06810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NCDO2118_RS06815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NCDO2118_RS06820	COG3763	UPF0154 protein
NCDO2118_RS06830	COG0493	'glutamate synthase
NCDO2118_RS06835	COG0067	glutamate synthase
NCDO2118_RS06835	COG0069	glutamate synthase activity
NCDO2118_RS06835	COG0070	glutamate synthase
NCDO2118_RS06845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NCDO2118_RS06850	COG0668	transmembrane transport
NCDO2118_RS06855	COG0076	glutamate decarboxylase activity
NCDO2118_RS06860	COG0531	amino acid
NCDO2118_RS06870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NCDO2118_RS06890	COG1349	DNA-binding transcription factor activity
NCDO2118_RS06900	COG0803	Belongs to the bacterial solute-binding protein 9 family
NCDO2118_RS06900	COG3443	Belongs to the bacterial solute-binding protein 9 family
NCDO2118_RS06920	COG0726	polysaccharide deacetylase
NCDO2118_RS06965	COG3655	Transcriptional regulator
NCDO2118_RS06975	COG0406	alpha-ribazole phosphatase activity
NCDO2118_RS06980	COG0561	phosphatase activity
NCDO2118_RS06985	COG0561	phosphatase activity
NCDO2118_RS06990	COG0110	maltose O-acetyltransferase activity
NCDO2118_RS06995	COG0346	lactoylglutathione lyase activity
NCDO2118_RS07005	COG3961	Belongs to the TPP enzyme family
NCDO2118_RS07040	COG1393	Belongs to the ArsC family
NCDO2118_RS07100	COG0803	Belongs to the bacterial solute-binding protein 9 family
NCDO2118_RS07125	COG0419	ATPase involved in DNA repair
NCDO2118_RS07130	COG0420	3'-5' exonuclease activity
NCDO2118_RS07135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NCDO2118_RS07140	COG1393	Belongs to the ArsC family
NCDO2118_RS07155	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NCDO2118_RS07160	COG2226	methyltransferase
NCDO2118_RS07165	COG3845	ABC transporter
NCDO2118_RS07170	COG4603	Belongs to the binding-protein-dependent transport system permease family
NCDO2118_RS07175	COG1079	Belongs to the binding-protein-dependent transport system permease family
NCDO2118_RS07180	COG0039	L-malate dehydrogenase activity
NCDO2118_RS07185	COG0469	pyruvate kinase activity
NCDO2118_RS07190	COG0205	6-phosphofructokinase activity
NCDO2118_RS07205	COG3853	Toxic anion resistance protein (TelA)
NCDO2118_RS07215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NCDO2118_RS07235	COG0142	geranyltranstransferase activity
NCDO2118_RS07240	COG0357	Ribosomal RNA small subunit methyltransferase G
NCDO2118_RS07250	COG0284	orotidine-5'-phosphate decarboxylase activity
NCDO2118_RS07255	COG0167	dihydroorotate dehydrogenase activity
NCDO2118_RS07260	COG0543	2 iron, 2 sulfur cluster binding
NCDO2118_RS07265	COG0477	Major facilitator Superfamily
NCDO2118_RS07270	COG2188	Transcriptional regulator
NCDO2118_RS07275	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS07290	COG1175	transmembrane transport
NCDO2118_RS07330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NCDO2118_RS07335	COG0386	Belongs to the glutathione peroxidase family
NCDO2118_RS07340	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS07345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS07385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCDO2118_RS07415	COG0589	response to stress
NCDO2118_RS07465	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NCDO2118_RS07470	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS07485	COG2188	Transcriptional regulator
NCDO2118_RS07490	COG1744	ABC transporter substrate-binding protein PnrA-like
NCDO2118_RS07500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NCDO2118_RS07515	COG2813	Specifically methylates the guanine in position
NCDO2118_RS07520	COG1072	(Pantothenic acid kinase))
NCDO2118_RS07525	COG3223	Belongs to the PsiE family
NCDO2118_RS07540	COG1475	DNA binding
NCDO2118_RS07565	COG4175	Glycine betaine
NCDO2118_RS07565	COG3448	diguanylate cyclase activity
NCDO2118_RS07575	COG0438	transferase activity, transferring glycosyl groups
NCDO2118_RS07585	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS07590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCDO2118_RS07590	COG2190	(PTS) system
NCDO2118_RS07590	COG1263	PTS System
NCDO2118_RS07595	COG3711	transcriptional antiterminator
NCDO2118_RS07600	COG0159	tryptophan synthase activity
NCDO2118_RS07605	COG0133	tryptophan synthase activity
NCDO2118_RS07615	COG0135	phosphoribosylanthranilate isomerase activity
NCDO2118_RS07620	COG0134	indole-3-glycerol-phosphate synthase activity
NCDO2118_RS07625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NCDO2118_RS07630	COG0512	Glutamine amidotransferase of anthranilate synthase
NCDO2118_RS07635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NCDO2118_RS07640	COG3759	membrane
NCDO2118_RS07645	COG0778	Nitroreductase
NCDO2118_RS07670	COG0735	belongs to the Fur family
NCDO2118_RS07675	COG0697	spore germination
NCDO2118_RS07680	COG0789	Transcriptional regulator
NCDO2118_RS07685	COG4221	oxidoreductase activity
NCDO2118_RS07695	COG0347	Belongs to the P(II) protein family
NCDO2118_RS07700	COG3842	ATPase activity
NCDO2118_RS07710	COG1177	transmembrane transport
NCDO2118_RS07755	COG0395	ABC-type sugar transport system, permease component
NCDO2118_RS07760	COG4209	transmembrane transport
NCDO2118_RS07765	COG0519	Catalyzes the synthesis of GMP from XMP
NCDO2118_RS07765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NCDO2118_RS07780	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS07795	COG0366	Alpha amylase catalytic
NCDO2118_RS07805	COG1653	transport
NCDO2118_RS07810	COG0395	ABC-type sugar transport system, permease component
NCDO2118_RS07815	COG1175	transmembrane transport
NCDO2118_RS07820	COG0383	alpha-mannosidase activity
NCDO2118_RS07840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NCDO2118_RS07845	COG2160	L-arabinose isomerase activity
NCDO2118_RS07850	COG0235	Class ii aldolase
NCDO2118_RS07865	COG3940	Belongs to the glycosyl hydrolase 43 family
NCDO2118_RS07870	COG2211	Major facilitator Superfamily
NCDO2118_RS07890	COG3507	Belongs to the glycosyl hydrolase 43 family
NCDO2118_RS07895	COG2211	Major facilitator Superfamily
NCDO2118_RS07905	COG1070	Carbohydrate kinase
NCDO2118_RS07910	COG2115	Belongs to the xylose isomerase family
NCDO2118_RS07925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NCDO2118_RS07930	COG0151	Belongs to the GarS family
NCDO2118_RS07940	COG2814	Major facilitator Superfamily
NCDO2118_RS07945	COG1011	Hydrolase
NCDO2118_RS07950	COG0138	bifunctional purine biosynthesis protein purh
NCDO2118_RS07970	COG1132	(ABC) transporter
NCDO2118_RS07975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NCDO2118_RS07980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NCDO2118_RS07985	COG0542	response to heat
NCDO2118_RS08005	COG4221	oxidoreductase activity
NCDO2118_RS08010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NCDO2118_RS08015	COG0047	phosphoribosylformylglycinamidine synthase activity
NCDO2118_RS08025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NCDO2118_RS08040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NCDO2118_RS08050	COG4221	oxidoreductase activity
NCDO2118_RS08055	COG0477	Major facilitator Superfamily
NCDO2118_RS08060	COG1846	Transcriptional regulator
NCDO2118_RS08065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NCDO2118_RS08105	COG1063	alcohol dehydrogenase
NCDO2118_RS08120	COG0167	dihydroorotate dehydrogenase activity
NCDO2118_RS08125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NCDO2118_RS08130	COG0673	inositol 2-dehydrogenase activity
NCDO2118_RS08140	COG0488	(ABC) transporter
NCDO2118_RS08145	COG0583	DNA-binding transcription factor activity
NCDO2118_RS08150	COG0371	Dehydrogenase
NCDO2118_RS08160	COG4690	dipeptidase activity
NCDO2118_RS08165	COG0617	tRNA 3'-terminal CCA addition
NCDO2118_RS08175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NCDO2118_RS08180	COG1307	EDD domain protein, DegV family
NCDO2118_RS08190	COG0336	Belongs to the RNA methyltransferase TrmD family
NCDO2118_RS08195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NCDO2118_RS08205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NCDO2118_RS08210	COG1837	Belongs to the UPF0109 family
NCDO2118_RS08215	COG0228	four-way junction DNA binding
NCDO2118_RS08225	COG0183	Belongs to the thiolase family
NCDO2118_RS08230	COG3425	synthase
NCDO2118_RS08235	COG0363	glucosamine-6-phosphate deaminase activity
NCDO2118_RS08245	COG3711	transcriptional antiterminator
NCDO2118_RS08245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS08250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS08250	COG2213	PTS system mannitol-specific
NCDO2118_RS08255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCDO2118_RS08260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCDO2118_RS08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS08260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCDO2118_RS08265	COG0383	alpha-mannosidase activity
NCDO2118_RS08270	COG0800	Aldolase
NCDO2118_RS08275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCDO2118_RS08285	COG2721	sulfolactate sulfo-lyase activity
NCDO2118_RS08290	COG0246	Mannitol dehydrogenase
NCDO2118_RS08295	COG1904	glucuronate isomerase
NCDO2118_RS08300	COG2211	Major facilitator Superfamily
NCDO2118_RS08305	COG1609	Transcriptional regulator
NCDO2118_RS08355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NCDO2118_RS08410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NCDO2118_RS08420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NCDO2118_RS08425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NCDO2118_RS08430	COG0347	Belongs to the P(II) protein family
NCDO2118_RS08435	COG0004	ammonium transporteR
NCDO2118_RS08440	COG5002	protein histidine kinase activity
NCDO2118_RS08445	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS08450	COG1399	metal-binding, possibly nucleic acid-binding protein
NCDO2118_RS08455	COG0254	rRNA binding
NCDO2118_RS08485	COG0589	response to stress
NCDO2118_RS08495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCDO2118_RS08665	COG0756	dUTP diphosphatase activity
NCDO2118_RS08700	COG4806	L-rhamnose isomerase
NCDO2118_RS08710	COG3723	Recombinational DNA repair protein, rece pathway
NCDO2118_RS08790	COG0582	viral genome integration into host DNA
NCDO2118_RS08795	COG0505	Belongs to the CarA family
NCDO2118_RS08800	COG0540	Belongs to the ATCase OTCase family
NCDO2118_RS08810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NCDO2118_RS08825	COG1230	cation diffusion facilitator family transporter
NCDO2118_RS08830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NCDO2118_RS08835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NCDO2118_RS08865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NCDO2118_RS08870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NCDO2118_RS08890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NCDO2118_RS08900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NCDO2118_RS08930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCDO2118_RS08935	COG0800	Aldolase
NCDO2118_RS08940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCDO2118_RS08945	COG1904	glucuronate isomerase
NCDO2118_RS08960	COG1312	Catalyzes the dehydration of D-mannonate
NCDO2118_RS08965	COG0246	Mannitol dehydrogenase
NCDO2118_RS08970	COG1802	Transcriptional regulator
NCDO2118_RS08975	COG0477	Major facilitator Superfamily
NCDO2118_RS08980	COG1879	ABC-type sugar transport system periplasmic component
NCDO2118_RS08985	COG1172	Belongs to the binding-protein-dependent transport system permease family
NCDO2118_RS08990	COG1129	ABC transporter
NCDO2118_RS08995	COG1869	D-ribose catabolic process
NCDO2118_RS09000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCDO2118_RS09005	COG1609	Transcriptional regulator
NCDO2118_RS09010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NCDO2118_RS09015	COG0710	3-dehydroquinate dehydratase activity
NCDO2118_RS09030	COG3118	belongs to the thioredoxin family
NCDO2118_RS09035	COG1193	negative regulation of DNA recombination
NCDO2118_RS09045	COG0492	ferredoxin-NADP+ reductase activity
NCDO2118_RS09050	COG1609	Transcriptional regulator
NCDO2118_RS09055	COG0006	proline dipeptidase activity
NCDO2118_RS09065	COG0116	Belongs to the methyltransferase superfamily
NCDO2118_RS09075	COG3599	regulation of cell shape
NCDO2118_RS09080	COG1466	dna polymerase III delta subunit
NCDO2118_RS09090	COG1674	ftsk spoiiie
NCDO2118_RS09095	COG0561	phosphatase activity
NCDO2118_RS09105	COG0280	phosphate acetyltransferase
NCDO2118_RS09110	COG0572	uridine kinase
NCDO2118_RS09115	COG0673	inositol 2-dehydrogenase activity
NCDO2118_RS09125	COG0741	lytic transglycosylase activity
NCDO2118_RS09175	COG2723	6-phospho-beta-galactosidase activity
NCDO2118_RS09180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NCDO2118_RS09185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NCDO2118_RS09190	COG5002	protein histidine kinase activity
NCDO2118_RS09195	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS09200	COG1609	Transcriptional regulator
NCDO2118_RS09210	COG0366	Alpha amylase catalytic
NCDO2118_RS09220	COG0110	maltose O-acetyltransferase activity
NCDO2118_RS09225	COG0366	Alpha amylase catalytic
NCDO2118_RS09230	COG0366	Alpha amylase catalytic
NCDO2118_RS09240	COG1175	transmembrane transport
NCDO2118_RS09245	COG3833	ABC-type maltose transport systems, permease component
NCDO2118_RS09290	COG0640	Transcriptional regulator
NCDO2118_RS09295	COG1902	pentaerythritol trinitrate reductase activity
NCDO2118_RS09320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NCDO2118_RS09330	COG2957	Belongs to the agmatine deiminase family
NCDO2118_RS09335	COG0531	amino acid
NCDO2118_RS09340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NCDO2118_RS09345	COG2197	response regulator
NCDO2118_RS09355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NCDO2118_RS09375	COG3715	PTS system
NCDO2118_RS09380	COG3716	PTS system mannose fructose sorbose family IID component
NCDO2118_RS09400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NCDO2118_RS09420	COG1131	(ABC) transporter
NCDO2118_RS09440	COG1619	proteins homologs of microcin C7 resistance protein MccF
NCDO2118_RS09450	COG0704	Plays a role in the regulation of phosphate uptake
NCDO2118_RS09455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NCDO2118_RS09460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NCDO2118_RS09465	COG0581	inorganic phosphate transmembrane transporter activity
NCDO2118_RS09470	COG0573	inorganic phosphate transmembrane transporter activity
NCDO2118_RS09485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NCDO2118_RS09495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NCDO2118_RS09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NCDO2118_RS09505	COG4122	O-methyltransferase activity
NCDO2118_RS09510	COG1164	Oligoendopeptidase f
NCDO2118_RS09530	COG2252	PERMEase
NCDO2118_RS09535	COG0561	phosphatase activity
NCDO2118_RS09540	COG0247	lactate metabolic process
NCDO2118_RS09545	COG1139	Iron-sulfur cluster binding protein
NCDO2118_RS09550	COG1556	Lactate utilization protein
NCDO2118_RS09555	COG0670	Belongs to the BI1 family
NCDO2118_RS09570	COG0268	Binds directly to 16S ribosomal RNA
NCDO2118_RS09575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NCDO2118_RS09580	COG0406	alpha-ribazole phosphatase activity
NCDO2118_RS09585	COG0077	Prephenate dehydratase
NCDO2118_RS09590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NCDO2118_RS09595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NCDO2118_RS09600	COG0287	Prephenate dehydrogenase
NCDO2118_RS09605	COG5002	protein histidine kinase activity
NCDO2118_RS09610	COG0745	RESPONSE REGULATOR receiver
NCDO2118_RS09620	COG0577	efflux transmembrane transporter activity
NCDO2118_RS09625	COG1136	(ABC) transporter
NCDO2118_RS09635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NCDO2118_RS09655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NCDO2118_RS09660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NCDO2118_RS09670	COG0765	amino acid transport
NCDO2118_RS09675	COG1126	abc transporter atp-binding protein
NCDO2118_RS09690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NCDO2118_RS09695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NCDO2118_RS09700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NCDO2118_RS09705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NCDO2118_RS09710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NCDO2118_RS09715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NCDO2118_RS09720	COG0356	it plays a direct role in the translocation of protons across the membrane
NCDO2118_RS09735	COG0658	competence protein
NCDO2118_RS09735	COG2333	competence protein COMEC
NCDO2118_RS09740	COG1555	photosystem II stabilization
NCDO2118_RS09740	COG1596	polysaccharide export
NCDO2118_RS09750	COG4152	abc transporter atp-binding protein
NCDO2118_RS09770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NCDO2118_RS09780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NCDO2118_RS09780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NCDO2118_RS09785	COG1268	BioY protein
NCDO2118_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
NCDO2118_RS09795	COG0183	Belongs to the thiolase family
NCDO2118_RS09810	COG1028	Short-chain dehydrogenase reductase Sdr
NCDO2118_RS09820	COG0719	Fe-S assembly protein
NCDO2118_RS09835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NCDO2118_RS09840	COG0719	Fe-S assembly protein
NCDO2118_RS09850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NCDO2118_RS09855	COG4862	establishment of competence for transformation
NCDO2118_RS09860	COG1126	abc transporter atp-binding protein
NCDO2118_RS09875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NCDO2118_RS09880	COG0085	RNA polymerase activity
NCDO2118_RS09890	COG1396	sequence-specific DNA binding
NCDO2118_RS09895	COG3590	peptidase
NCDO2118_RS09905	COG2244	polysaccharide biosynthetic process
NCDO2118_RS09910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NCDO2118_RS09920	COG1064	alcohol dehydrogenase
NCDO2118_RS09925	COG0514	ATP-dependent DNA helicase (RecQ)
NCDO2118_RS09945	COG1227	inorganic diphosphatase activity
NCDO2118_RS09950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NCDO2118_RS09955	COG1253	flavin adenine dinucleotide binding
NCDO2118_RS09960	COG0628	permease
NCDO2118_RS10075	COG1573	uracil-dna glycosylase
NCDO2118_RS10080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NCDO2118_RS10090	COG2062	phosphohistidine phosphatase, SixA
NCDO2118_RS10095	COG2827	Endonuclease containing a URI domain
NCDO2118_RS10100	COG1113	amino acid transport
NCDO2118_RS10110	COG1564	THIamine pyrophosphokinase
NCDO2118_RS10125	COG0017	Asparaginyl-tRNA synthetase
NCDO2118_RS10135	COG0436	Aminotransferase
NCDO2118_RS10145	COG1199	ATP-dependent helicase activity
NCDO2118_RS10145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NCDO2118_RS10155	COG1253	flavin adenine dinucleotide binding
NCDO2118_RS10165	COG2365	Tyrosine phosphatase family
NCDO2118_RS10170	COG0747	negative chemotaxis
NCDO2118_RS10175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NCDO2118_RS10180	COG0601	transmembrane transport
NCDO2118_RS10185	COG4608	Belongs to the ABC transporter superfamily
NCDO2118_RS10190	COG0444	Belongs to the ABC transporter superfamily
NCDO2118_RS10195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NCDO2118_RS10200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NCDO2118_RS10205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NCDO2118_RS10220	COG0445	tRNA wobble uridine modification
NCDO2118_RS10235	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NCDO2118_RS10240	COG0215	cysteine-tRNA ligase activity
NCDO2118_RS10250	COG1045	serine acetyltransferase
NCDO2118_RS10260	COG1185	polyribonucleotide nucleotidyltransferase activity
NCDO2118_RS10270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NCDO2118_RS10275	COG0589	response to stress
NCDO2118_RS10280	COG1104	cysteine desulfurase activity
NCDO2118_RS10290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NCDO2118_RS10300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NCDO2118_RS10305	COG3599	regulation of cell shape
NCDO2118_RS10320	COG1799	cell septum assembly
NCDO2118_RS10325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NCDO2118_RS10330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NCDO2118_RS10335	COG0849	cell division
NCDO2118_RS10340	COG1307	EDD domain protein, DegV family
NCDO2118_RS10350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NCDO2118_RS10355	COG0656	L-ascorbic acid biosynthetic process
NCDO2118_RS10365	COG0583	DNA-binding transcription factor activity
NCDO2118_RS10375	COG3579	cysteine-type endopeptidase activity
NCDO2118_RS10385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NCDO2118_RS10395	COG0494	nUDIX hydrolase
NCDO2118_RS10400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NCDO2118_RS10405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NCDO2118_RS10410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NCDO2118_RS10415	COG0515	serine threonine protein kinase
NCDO2118_RS10415	COG2815	serine threonine protein kinase
NCDO2118_RS10420	COG0631	protein serine/threonine phosphatase activity
NCDO2118_RS10425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NCDO2118_RS10425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NCDO2118_RS10445	COG2261	transglycosylase associated protein
NCDO2118_RS10450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NCDO2118_RS10470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NCDO2118_RS10475	COG1758	RNA polymerase activity
NCDO2118_RS10480	COG0194	GDP metabolic process
NCDO2118_RS10485	COG1418	mRNA catabolic process
NCDO2118_RS10490	COG0363	glucosamine-6-phosphate deaminase activity
NCDO2118_RS10495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NCDO2118_RS10500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NCDO2118_RS10505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NCDO2118_RS10505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NCDO2118_RS10525	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS10525	COG3942	CHAP domain
NCDO2118_RS10530	COG0191	fructose-bisphosphate aldolase activity
NCDO2118_RS10590	COG2860	membrane
NCDO2118_RS10595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NCDO2118_RS10615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NCDO2118_RS10625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NCDO2118_RS10630	COG0626	cystathionine gamma-synthase activity
NCDO2118_RS10635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NCDO2118_RS10655	COG3481	metal-dependent phosphohydrolase, HD sub domain
NCDO2118_RS10680	COG1162	GTPase activity
NCDO2118_RS10685	COG1388	LysM domain
NCDO2118_RS10685	COG3584	3D domain protein
NCDO2118_RS10690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCDO2118_RS10690	COG0072	phenylalanine-tRNA ligase activity
NCDO2118_RS10695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NCDO2118_RS10700	COG3479	Phenolic acid decarboxylase
NCDO2118_RS10710	COG3469	chitinase activity
NCDO2118_RS10715	COG3397	chitin binding
NCDO2118_RS10720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NCDO2118_RS10760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NCDO2118_RS10765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NCDO2118_RS10770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NCDO2118_RS10780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NCDO2118_RS10785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NCDO2118_RS10790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NCDO2118_RS10795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NCDO2118_RS10800	COG0537	adenosine 5'-monophosphoramidase activity
NCDO2118_RS10805	COG0124	histidyl-tRNA synthetase
NCDO2118_RS10835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NCDO2118_RS10840	COG1426	Protein conserved in bacteria
NCDO2118_RS10845	COG0612	Peptidase, M16
NCDO2118_RS10850	COG0612	Peptidase, M16
NCDO2118_RS10855	COG2501	S4 domain
NCDO2118_RS10860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NCDO2118_RS10865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NCDO2118_RS10870	COG0789	Transcriptional regulator
NCDO2118_RS10880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NCDO2118_RS10885	COG3250	beta-galactosidase activity
NCDO2118_RS10890	COG0110	maltose O-acetyltransferase activity
NCDO2118_RS10895	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NCDO2118_RS10900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NCDO2118_RS10920	COG0667	Aldo Keto reductase
NCDO2118_RS10935	COG0826	peptidase U32
NCDO2118_RS10960	COG0500	methyltransferase
NCDO2118_RS10975	COG1131	(ABC) transporter
NCDO2118_RS10980	COG0584	glycerophosphoryl diester phosphodiesterase
NCDO2118_RS10985	COG0537	adenosine 5'-monophosphoramidase activity
NCDO2118_RS11000	COG0081	regulation of translation
NCDO2118_RS11005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NCDO2118_RS11015	COG1131	(ABC) transporter
NCDO2118_RS11020	COG4479	Belongs to the UPF0346 family
NCDO2118_RS11025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NCDO2118_RS11030	COG2996	Protein conserved in bacteria
NCDO2118_RS11040	COG0233	cytoplasmic translational termination
NCDO2118_RS11055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NCDO2118_RS11060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NCDO2118_RS11065	COG0827	DNA restriction-modification system
NCDO2118_RS11075	COG1217	gtp-binding protein TYPA
NCDO2118_RS11090	COG0577	efflux transmembrane transporter activity
NCDO2118_RS11090	COG1136	(ABC) transporter
NCDO2118_RS11115	COG1940	carbohydrate kinase activity
NCDO2118_RS11125	COG0783	Belongs to the Dps family
NCDO2118_RS11135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NCDO2118_RS11145	COG0531	amino acid
NCDO2118_RS11150	COG0436	Aminotransferase
NCDO2118_RS11165	COG0531	amino acid
NCDO2118_RS11170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NCDO2118_RS11175	COG2235	arginine
NCDO2118_RS11185	COG0018	arginyl-trna synthetase
NCDO2118_RS11195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NCDO2118_RS11220	COG0028	Belongs to the TPP enzyme family
NCDO2118_RS11225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NCDO2118_RS11235	COG1266	CAAX protease self-immunity
NCDO2118_RS11240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NCDO2118_RS11245	COG2936	dipeptidyl-peptidase activity
NCDO2118_RS11250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NCDO2118_RS11255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NCDO2118_RS11260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NCDO2118_RS11265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NCDO2118_RS11305	COG4956	integral membrane protein (PIN domain superfamily)
NCDO2118_RS11325	COG1216	Glycosyl transferase, family 2
NCDO2118_RS11325	COG1442	glycosyl transferase family 8
NCDO2118_RS11330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NCDO2118_RS11335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NCDO2118_RS11355	COG1216	Glycosyl transferase, family 2
NCDO2118_RS11360	COG1215	transferase activity, transferring glycosyl groups
NCDO2118_RS11375	COG0203	ribosomal protein L17
NCDO2118_RS11380	COG0202	RNA polymerase activity
NCDO2118_RS11385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NCDO2118_RS11390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NCDO2118_RS11395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NCDO2118_RS11400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NCDO2118_RS11405	COG0563	adenylate kinase activity
NCDO2118_RS11410	COG0201	protein transport
NCDO2118_RS11415	COG0200	Binds to the 23S rRNA
NCDO2118_RS11420	COG1841	ribosomal large subunit assembly
NCDO2118_RS11425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NCDO2118_RS11430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NCDO2118_RS11435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NCDO2118_RS11440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NCDO2118_RS11450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NCDO2118_RS11455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NCDO2118_RS11460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NCDO2118_RS11465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NCDO2118_RS11470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NCDO2118_RS11475	COG0255	Belongs to the universal ribosomal protein uL29 family
NCDO2118_RS11480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NCDO2118_RS11485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NCDO2118_RS11490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NCDO2118_RS11495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NCDO2118_RS11500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NCDO2118_RS11510	COG0088	Forms part of the polypeptide exit tunnel
NCDO2118_RS11515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NCDO2118_RS11520	COG0051	transcription antitermination factor activity, RNA binding
NCDO2118_RS11525	COG1970	mechanosensitive ion channel activity
NCDO2118_RS11535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NCDO2118_RS11540	COG0250	Participates in transcription elongation, termination and antitermination
NCDO2118_RS11550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NCDO2118_RS11555	COG2755	lipolytic protein G-D-S-L family
NCDO2118_RS11555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NCDO2118_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NCDO2118_RS11565	COG2323	membrane
NCDO2118_RS11580	COG0564	pseudouridine synthase activity
NCDO2118_RS11585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NCDO2118_RS11590	COG1121	(ABC) transporter
NCDO2118_RS11595	COG3443	Belongs to the bacterial solute-binding protein 9 family
NCDO2118_RS11595	COG0803	Belongs to the bacterial solute-binding protein 9 family
NCDO2118_RS11600	COG1846	Transcriptional regulator
NCDO2118_RS11625	COG4537	Required for transformation and DNA binding
NCDO2118_RS11630	COG1459	type II secretion system
NCDO2118_RS11635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NCDO2118_RS11650	COG2176	DNA-directed DNA polymerase activity
NCDO2118_RS11660	COG0446	pyridine nucleotide-disulphide oxidoreductase
NCDO2118_RS11665	COG0442	prolyl-tRNA aminoacylation
NCDO2118_RS11670	COG0750	zinc metalloprotease
NCDO2118_RS11675	COG4589	Belongs to the CDS family
NCDO2118_RS11680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NCDO2118_RS11685	COG1862	Preprotein translocase
NCDO2118_RS11695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NCDO2118_RS11700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NCDO2118_RS11710	COG0438	transferase activity, transferring glycosyl groups
NCDO2118_RS11725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NCDO2118_RS11730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NCDO2118_RS11730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NCDO2118_RS11735	COG0561	phosphatase activity
NCDO2118_RS11740	COG1609	Transcriptional regulator
NCDO2118_RS11770	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NCDO2118_RS11775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NCDO2118_RS11780	COG0052	Belongs to the universal ribosomal protein uS2 family
NCDO2118_RS11785	COG2706	6-phosphogluconolactonase activity
NCDO2118_RS11790	COG1454	alcohol dehydrogenase
NCDO2118_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
NCDO2118_RS11815	COG1396	sequence-specific DNA binding
NCDO2118_RS11825	COG0535	radical SAM domain protein
NCDO2118_RS11830	COG3480	Lon protease (S16) C-terminal proteolytic domain
NCDO2118_RS11835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NCDO2118_RS11840	COG0742	ribosomal rna small subunit methyltransferase
NCDO2118_RS11845	COG2814	Major facilitator Superfamily
NCDO2118_RS11865	COG0166	Belongs to the GPI family
NCDO2118_RS11875	COG0702	epimerase
NCDO2118_RS11880	COG1733	regulation of RNA biosynthetic process
NCDO2118_RS11890	COG0525	valine-tRNA ligase activity
NCDO2118_RS11920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NCDO2118_RS11930	COG2137	regulation of response to DNA damage stimulus
NCDO2118_RS11960	COG1070	Carbohydrate kinase
NCDO2118_RS11965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NCDO2118_RS11980	COG1408	metallophosphoesterase
NCDO2118_RS11985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NCDO2118_RS11990	COG0629	single-stranded DNA binding
NCDO2118_RS11995	COG0360	Binds together with S18 to 16S ribosomal RNA
NCDO2118_RS12000	COG1968	undecaprenyl-diphosphatase activity
NCDO2118_RS12005	COG0833	amino acid
NCDO2118_RS12010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NCDO2118_RS12020	COG1956	GAF domain-containing protein
NCDO2118_RS12025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NCDO2118_RS12025	COG1605	Chorismate mutase
NCDO2118_RS12035	COG4974	Belongs to the 'phage' integrase family
NCDO2118_RS12170	COG0174	glutamine synthetase
NCDO2118_RS12175	COG0789	Transcriptional regulator
NCDO2118_RS12180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCDO2118_RS12185	COG1131	(ABC) transporter
NCDO2118_RS12205	COG2255	four-way junction helicase activity
NCDO2118_RS12210	COG0632	four-way junction helicase activity
NCDO2118_RS12215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NCDO2118_RS12225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NCDO2118_RS12235	COG2084	Dehydrogenase
NCDO2118_RS12255	COG0730	response to heat
NCDO2118_RS12265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NCDO2118_RS12270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NCDO2118_RS12275	COG0484	heat shock protein binding
NCDO2118_RS12295	COG0367	asparagine synthase
NCDO2118_RS12300	COG3942	CHAP domain
NCDO2118_RS12300	COG3883	PFAM NLP P60 protein
NCDO2118_RS12315	COG0494	nUDIX hydrolase
NCDO2118_RS12320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NCDO2118_RS12325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NCDO2118_RS12330	COG2814	Major facilitator Superfamily
NCDO2118_RS12335	COG0589	response to stress
NCDO2118_RS12350	COG1309	transcriptional regulator
NCDO2118_RS12355	COG1187	pseudouridine synthase activity
NCDO2118_RS12365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NCDO2118_RS12375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NCDO2118_RS12380	COG2824	Alkylphosphonate utilization operon protein PhnA
NCDO2118_RS12395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCDO2118_RS12465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NCDO2118_RS12470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NCDO2118_RS12480	COG1136	(ABC) transporter
NCDO2118_RS12485	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NCDO2118_RS12490	COG0681	Belongs to the peptidase S26 family
NCDO2118_RS12495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NCDO2118_RS12500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NCDO2118_RS12505	COG0049	tRNA binding
NCDO2118_RS12510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NCDO2118_RS12515	COG1686	Belongs to the peptidase S11 family
NCDO2118_RS12520	COG4975	Glucose uptake
NCDO2118_RS12525	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NCDO2118_RS12530	COG1242	4 iron, 4 sulfur cluster binding
NCDO2118_RS12745	COG1705	Flagellar rod assembly protein muramidase FlgJ
NCDO2118_RS12745	COG3942	CHAP domain
NCDO2118_RS12810	COG1396	sequence-specific DNA binding