locus-tag	class	description
CG419_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG419_RS00010	COG0592	DNA-directed DNA polymerase activity
CG419_RS00015	COG2501	S4 domain
CG419_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG419_RS00025	COG0187	DNA topoisomerase II activity
CG419_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG419_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
CG419_RS00040	COG0629	single-stranded DNA binding
CG419_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG419_RS00055	COG0359	binds to the 23S rRNA
CG419_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
CG419_RS00065	COG2233	PERMEase
CG419_RS00070	COG0357	Ribosomal RNA small subunit methyltransferase G
CG419_RS00075	COG1475	DNA binding
CG419_RS00080	COG1192	Involved in chromosome partitioning
CG419_RS00085	COG1475	DNA binding
CG419_RS00090	COG4481	Protein conserved in bacteria
CG419_RS00095	COG0012	GTP binding
CG419_RS00105	COG1073	alpha beta
CG419_RS00115	COG1780	Probably involved in ribonucleotide reductase function
CG419_RS00140	COG1307	EDD domain protein, DegV family
CG419_RS00145	COG1253	flavin adenine dinucleotide binding
CG419_RS00150	COG0656	L-ascorbic acid biosynthetic process
CG419_RS00185	COG2814	Major facilitator Superfamily
CG419_RS00190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CG419_RS00195	COG2365	Tyrosine phosphatase family
CG419_RS00210	COG0519	Catalyzes the synthesis of GMP from XMP
CG419_RS00220	COG1121	(ABC) transporter
CG419_RS00230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG419_RS00250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG419_RS00255	COG0628	permease
CG419_RS00270	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG419_RS00285	COG4152	abc transporter atp-binding protein
CG419_RS00290	COG1668	transmembrane transport
CG419_RS00300	COG3590	peptidase
CG419_RS00305	COG0110	maltose O-acetyltransferase activity
CG419_RS00310	COG0352	thiamine-phosphate diphosphorylase activity
CG419_RS00315	COG0351	phosphomethylpyrimidine kinase
CG419_RS00320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG419_RS00325	COG2190	(PTS) system
CG419_RS00325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS00325	COG1263	PTS System
CG419_RS00340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG419_RS00345	COG2252	PERMEase
CG419_RS00350	COG3764	Sortase (surface protein transpeptidase)
CG419_RS00370	COG0745	RESPONSE REGULATOR receiver
CG419_RS00390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG419_RS00395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG419_RS00400	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG419_RS00420	COG2814	Major facilitator Superfamily
CG419_RS00425	COG2190	(PTS) system
CG419_RS00425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS00425	COG1263	PTS System
CG419_RS00430	COG2723	6-phospho-beta-galactosidase activity
CG419_RS00435	COG3711	transcriptional antiterminator
CG419_RS00455	COG0383	alpha-mannosidase activity
CG419_RS00460	COG3842	ATPase activity
CG419_RS00470	COG2207	Transcriptional regulator
CG419_RS00470	COG1917	Cupin 2, conserved barrel domain protein
CG419_RS00475	COG1132	(ABC) transporter
CG419_RS00480	COG1132	(ABC) transporter
CG419_RS00500	COG0395	ABC-type sugar transport system, permease component
CG419_RS00505	COG1653	transport
CG419_RS00515	COG2972	Histidine kinase
CG419_RS00520	COG2197	response regulator
CG419_RS00525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG419_RS00530	COG1125	glycine betaine transport
CG419_RS00530	COG0517	IMP dehydrogenase activity
CG419_RS00535	COG1174	glycine betaine transport
CG419_RS00545	COG0110	maltose O-acetyltransferase activity
CG419_RS00560	COG0588	phosphoglycerate mutase activity
CG419_RS00570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CG419_RS00585	COG0383	alpha-mannosidase activity
CG419_RS00590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS00595	COG2188	Transcriptional regulator
CG419_RS00600	COG1522	sequence-specific DNA binding
CG419_RS00605	COG1335	isochorismatase
CG419_RS00620	COG1881	PFAM PEBP family protein
CG419_RS00640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG419_RS00645	COG1136	(ABC) transporter
CG419_RS00650	COG0577	efflux transmembrane transporter activity
CG419_RS00715	COG4869	propanediol catabolic process
CG419_RS00750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG419_RS00810	COG0604	alcohol dehydrogenase
CG419_RS00810	COG3321	synthase
CG419_RS00815	COG2837	iron assimilation
CG419_RS00820	COG0028	Belongs to the TPP enzyme family
CG419_RS00825	COG0398	Pfam SNARE associated Golgi protein
CG419_RS00830	COG1757	Na H antiporter
CG419_RS00850	COG1959	2 iron, 2 sulfur cluster binding
CG419_RS00870	COG0833	amino acid
CG419_RS00925	COG1428	Deoxynucleoside kinase
CG419_RS00935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG419_RS00940	COG3711	transcriptional antiterminator
CG419_RS00945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS00945	COG2190	(PTS) system
CG419_RS00945	COG1263	PTS System
CG419_RS00950	COG2723	6-phospho-beta-galactosidase activity
CG419_RS00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS00960	COG1263	PTS System
CG419_RS00965	COG1737	Transcriptional regulator
CG419_RS00980	COG1511	domain protein
CG419_RS00985	COG2188	Transcriptional regulator
CG419_RS00990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS00995	COG2723	6-phospho-beta-galactosidase activity
CG419_RS01015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG419_RS01095	COG4463	regulation of RNA biosynthetic process
CG419_RS01100	COG0542	response to heat
CG419_RS01105	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CG419_RS01110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG419_RS01120	COG0085	RNA polymerase activity
CG419_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG419_RS01135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG419_RS01140	COG0049	tRNA binding
CG419_RS01145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG419_RS01150	COG1162	GTPase activity
CG419_RS01155	COG1335	isochorismatase
CG419_RS01160	COG0051	transcription antitermination factor activity, RNA binding
CG419_RS01165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG419_RS01170	COG0088	Forms part of the polypeptide exit tunnel
CG419_RS01175	COG0089	rRNA binding
CG419_RS01180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG419_RS01185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG419_RS01190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG419_RS01195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG419_RS01200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG419_RS01205	COG0255	Belongs to the universal ribosomal protein uL29 family
CG419_RS01210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG419_RS01215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG419_RS01220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG419_RS01225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG419_RS01235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG419_RS01240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG419_RS01245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG419_RS01250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG419_RS01255	COG1841	ribosomal large subunit assembly
CG419_RS01260	COG0200	Binds to the 23S rRNA
CG419_RS01270	COG0563	adenylate kinase activity
CG419_RS01275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CG419_RS01280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG419_RS01285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CG419_RS01290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG419_RS01295	COG0202	RNA polymerase activity
CG419_RS01300	COG0203	ribosomal protein L17
CG419_RS01305	COG1122	ATPase activity
CG419_RS01310	COG1122	ATPase activity
CG419_RS01325	COG0101	tRNA pseudouridine synthase activity
CG419_RS01330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG419_RS01335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG419_RS01350	COG1597	lipid kinase activity
CG419_RS01355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS01360	COG2723	6-phospho-beta-galactosidase activity
CG419_RS01365	COG2188	Transcriptional regulator
CG419_RS01370	COG0640	Transcriptional regulator
CG419_RS01390	COG0778	Nitroreductase
CG419_RS01440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG419_RS01450	COG3479	Phenolic acid decarboxylase
CG419_RS01480	COG0488	(ABC) transporter
CG419_RS01500	COG3118	belongs to the thioredoxin family
CG419_RS01505	COG2814	Major facilitator Superfamily
CG419_RS01520	COG1737	Transcriptional regulator
CG419_RS01525	COG1486	melibiose metabolic process
CG419_RS01535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS01540	COG2723	6-phospho-beta-galactosidase activity
CG419_RS01565	COG0702	epimerase
CG419_RS01570	COG1760	l-serine dehydratase
CG419_RS01580	COG1297	OPT oligopeptide transporter protein
CG419_RS01595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG419_RS01600	COG1136	(ABC) transporter
CG419_RS01620	COG0561	phosphatase activity
CG419_RS01650	COG4939	FMN-binding domain protein
CG419_RS01660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG419_RS01670	COG0250	Participates in transcription elongation, termination and antitermination
CG419_RS01680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CG419_RS01685	COG0081	regulation of translation
CG419_RS01690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CG419_RS01695	COG2252	PERMEase
CG419_RS01700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG419_RS01705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG419_RS01710	COG0222	ribosome binding
CG419_RS01715	COG0392	lysyltransferase activity
CG419_RS01715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG419_RS01720	COG2813	Specifically methylates the guanine in position
CG419_RS01730	COG0590	tRNA wobble adenosine to inosine editing
CG419_RS01740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG419_RS01745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG419_RS01750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG419_RS01760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG419_RS01765	COG3870	Protein conserved in bacteria
CG419_RS01770	COG0470	DNA polymerase III
CG419_RS01775	COG4467	Involved in initiation control of chromosome replication
CG419_RS01795	COG4720	Psort location CytoplasmicMembrane, score
CG419_RS01800	COG1214	PFAM Peptidase M22, glycoprotease
CG419_RS01810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CG419_RS01815	COG3973	AAA domain
CG419_RS01825	COG0534	Mate efflux family protein
CG419_RS01835	COG4989	oxidoreductase activity
CG419_RS01845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CG419_RS01875	COG1801	Protein of unknown function DUF72
CG419_RS01880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG419_RS01880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG419_RS01885	COG0084	hydrolase, TatD family'
CG419_RS01890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG419_RS01895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG419_RS01900	COG4466	Protein conserved in bacteria
CG419_RS01905	COG1511	domain protein
CG419_RS01910	COG1846	Transcriptional regulator
CG419_RS01915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG419_RS01920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG419_RS01925	COG2376	Dihydroxyacetone kinase
CG419_RS01930	COG1461	Dihydroxyacetone kinase
CG419_RS01935	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CG419_RS01945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG419_RS01960	COG1376	ErfK ybiS ycfS ynhG family protein
CG419_RS01965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG419_RS01975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG419_RS01980	COG1970	mechanosensitive ion channel activity
CG419_RS01985	COG0861	Integral membrane protein TerC family
CG419_RS01995	COG0561	phosphatase activity
CG419_RS02000	COG1078	dGTPase activity
CG419_RS02015	COG3343	RNA polymerase activity
CG419_RS02025	COG0504	CTP synthase activity
CG419_RS02030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CG419_RS02035	COG0254	rRNA binding
CG419_RS02045	COG3548	integral membrane protein
CG419_RS02055	COG2814	Major facilitator Superfamily
CG419_RS02065	COG1704	LemA family
CG419_RS02070	COG0501	Belongs to the peptidase M48B family
CG419_RS02080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG419_RS02090	COG0736	holo-[acyl-carrier-protein] synthase activity
CG419_RS02095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG419_RS02105	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG419_RS02110	COG4708	membrane
CG419_RS02125	COG0039	L-malate dehydrogenase activity
CG419_RS02130	COG0193	aminoacyl-tRNA hydrolase activity
CG419_RS02135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG419_RS02140	COG2244	polysaccharide biosynthetic process
CG419_RS02145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG419_RS02155	COG1098	S1 RNA binding domain
CG419_RS02160	COG0037	tRNA processing
CG419_RS02165	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG419_RS02175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG419_RS02180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG419_RS02185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG419_RS02225	COG3104	oligopeptide transport
CG419_RS02240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG419_RS02255	COG2188	Transcriptional regulator
CG419_RS02260	COG1705	Flagellar rod assembly protein muramidase FlgJ
CG419_RS02285	COG0438	transferase activity, transferring glycosyl groups
CG419_RS02300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG419_RS02315	COG1088	dTDP-glucose 4,6-dehydratase activity
CG419_RS02325	COG1216	Glycosyl transferase, family 2
CG419_RS02330	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG419_RS02340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG419_RS02345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG419_RS02365	COG2183	response to ionizing radiation
CG419_RS02370	COG3091	SprT-like family
CG419_RS02395	COG1278	Cold shock
CG419_RS02410	COG1705	Flagellar rod assembly protein muramidase FlgJ
CG419_RS02415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG419_RS02420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG419_RS02425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG419_RS02430	COG1609	Transcriptional regulator
CG419_RS02435	COG0561	phosphatase activity
CG419_RS02445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG419_RS02450	COG4851	CamS sex pheromone cAM373 precursor
CG419_RS02465	COG1959	2 iron, 2 sulfur cluster binding
CG419_RS02480	COG0154	amidase activity
CG419_RS02485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG419_RS02490	COG1597	lipid kinase activity
CG419_RS02495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG419_RS02500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS02535	COG0673	inositol 2-dehydrogenase activity
CG419_RS02545	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG419_RS02555	COG2723	6-phospho-beta-galactosidase activity
CG419_RS02560	COG1827	regulation of RNA biosynthetic process
CG419_RS02565	COG0477	Major facilitator Superfamily
CG419_RS02585	COG2076	Multidrug Resistance protein
CG419_RS02600	COG2309	aminopeptidase activity
CG419_RS02610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG419_RS02615	COG0463	Glycosyl transferase, family 2
CG419_RS02625	COG2246	polysaccharide biosynthetic process
CG419_RS02630	COG0716	FMN binding
CG419_RS02635	COG0024	Methionine aminopeptidase
CG419_RS02645	COG1316	TRANSCRIPTIONal
CG419_RS02650	COG3944	biosynthesis protein
CG419_RS02655	COG0489	protein tyrosine kinase activity
CG419_RS02660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CG419_RS02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG419_RS02700	COG1063	alcohol dehydrogenase
CG419_RS02705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG419_RS02715	COG1088	dTDP-glucose 4,6-dehydratase activity
CG419_RS02720	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG419_RS02735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG419_RS02740	COG0242	peptide deformylase activity
CG419_RS02745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS02750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS02760	COG0765	amino acid transport
CG419_RS02795	COG0183	Belongs to the thiolase family
CG419_RS02805	COG3425	synthase
CG419_RS02820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG419_RS02830	COG2137	regulation of response to DNA damage stimulus
CG419_RS02835	COG1194	a g-specific adenine glycosylase
CG419_RS02840	COG3557	Belongs to the UPF0374 family
CG419_RS02855	COG0628	permease
CG419_RS02860	COG1253	flavin adenine dinucleotide binding
CG419_RS02865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CG419_RS02885	COG0542	response to heat
CG419_RS02910	COG2217	Heavy metal translocating P-type atpase
CG419_RS02920	COG0602	queuosine metabolic process
CG419_RS02925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS02935	COG2205	protein histidine kinase activity
CG419_RS02940	COG0745	RESPONSE REGULATOR receiver
CG419_RS02945	COG1136	(ABC) transporter
CG419_RS02960	COG1234	tRNA 3'-trailer cleavage
CG419_RS02965	COG1393	Belongs to the ArsC family
CG419_RS02970	COG4862	establishment of competence for transformation
CG419_RS02990	COG2357	RelA SpoT domain protein
CG419_RS02995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG419_RS03000	COG0564	pseudouridine synthase activity
CG419_RS03005	COG1968	undecaprenyl-diphosphatase activity
CG419_RS03010	COG3142	Participates in the control of copper homeostasis
CG419_RS03015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG419_RS03020	COG0671	phosphoesterase, PA-phosphatase related
CG419_RS03025	COG1705	Flagellar rod assembly protein muramidase FlgJ
CG419_RS03025	COG1388	LysM domain
CG419_RS03030	COG0495	leucyl-tRNA aminoacylation
CG419_RS03035	COG1113	amino acid transport
CG419_RS03040	COG1733	regulation of RNA biosynthetic process
CG419_RS03045	COG2814	Major facilitator Superfamily
CG419_RS03050	COG2244	polysaccharide biosynthetic process
CG419_RS03055	COG1187	pseudouridine synthase activity
CG419_RS03060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CG419_RS03075	COG0561	phosphatase activity
CG419_RS03080	COG2267	carboxylic ester hydrolase activity
CG419_RS03085	COG0531	amino acid
CG419_RS03100	COG0577	efflux transmembrane transporter activity
CG419_RS03100	COG1136	(ABC) transporter
CG419_RS03105	COG0018	arginyl-trna synthetase
CG419_RS03110	COG1073	alpha beta
CG419_RS03125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG419_RS03135	COG0557	exoribonuclease II activity
CG419_RS03140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG419_RS03145	COG3583	domain protein
CG419_RS03145	COG3584	3D domain protein
CG419_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CG419_RS03165	COG0237	dephospho-CoA kinase activity
CG419_RS03170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG419_RS03175	COG3611	Membrane attachment protein
CG419_RS03180	COG1484	DNA-dependent DNA replication
CG419_RS03185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG419_RS03190	COG1304	FMN binding
CG419_RS03195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG419_RS03200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG419_RS03205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG419_RS03210	COG1063	alcohol dehydrogenase
CG419_RS03215	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG419_RS03220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG419_RS03230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG419_RS03235	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG419_RS03240	COG0799	negative regulation of ribosome biogenesis
CG419_RS03245	COG2226	methyltransferase
CG419_RS03250	COG1323	Belongs to the UPF0348 family
CG419_RS03260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CG419_RS03265	COG0745	RESPONSE REGULATOR receiver
CG419_RS03270	COG5002	protein histidine kinase activity
CG419_RS03275	COG0706	membrane insertase activity
CG419_RS03280	COG1254	Belongs to the acylphosphatase family
CG419_RS03285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG419_RS03295	COG1733	regulation of RNA biosynthetic process
CG419_RS03300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG419_RS03305	COG0072	phenylalanine-tRNA ligase activity
CG419_RS03310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG419_RS03315	COG0572	uridine kinase
CG419_RS03320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG419_RS03330	COG4585	Histidine kinase
CG419_RS03340	COG4841	protein insertion into membrane
CG419_RS03345	COG0604	alcohol dehydrogenase
CG419_RS03350	COG3842	ATPase activity
CG419_RS03355	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG419_RS03360	COG1177	transmembrane transport
CG419_RS03380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG419_RS03390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CG419_RS03395	COG0180	Tryptophanyl-tRNA synthetase
CG419_RS03410	COG4475	Protein of unknown function (DUF436)
CG419_RS03420	COG0351	phosphomethylpyrimidine kinase
CG419_RS03425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG419_RS03440	COG1811	Na channel or pump
CG419_RS03450	COG0561	phosphatase activity
CG419_RS03455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG419_RS03460	COG0280	phosphate acetyltransferase
CG419_RS03465	COG0802	atpase or kinase
CG419_RS03475	COG0697	spore germination
CG419_RS03480	COG2176	DNA-directed DNA polymerase activity
CG419_RS03485	COG0708	Exodeoxyribonuclease III
CG419_RS03490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CG419_RS03500	COG4485	Bacterial membrane protein, YfhO
CG419_RS03505	COG0768	penicillin binding
CG419_RS03510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG419_RS03515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG419_RS03530	COG1940	carbohydrate kinase activity
CG419_RS03545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG419_RS03550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG419_RS03560	COG0519	Catalyzes the synthesis of GMP from XMP
CG419_RS03565	COG0789	Transcriptional regulator
CG419_RS03570	COG0174	glutamine synthetase
CG419_RS03575	COG2249	NAD(P)H dehydrogenase (quinone) activity
CG419_RS03580	COG0431	NADPH-dependent FMN reductase
CG419_RS03585	COG0564	pseudouridine synthase activity
CG419_RS03595	COG0534	Mate efflux family protein
CG419_RS03600	COG0583	DNA-binding transcription factor activity
CG419_RS03605	COG2855	membrane
CG419_RS03635	COG0217	transcriptional regulatory protein
CG419_RS03640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG419_RS03645	COG1459	type II secretion system
CG419_RS03670	COG0827	DNA restriction-modification system
CG419_RS03675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG419_RS03690	COG3152	Membrane
CG419_RS03715	COG0481	GTPase activity
CG419_RS03720	COG4974	Belongs to the 'phage' integrase family
CG419_RS03870	COG0270	DNA (cytosine-5-)-methyltransferase activity
CG419_RS03915	COG5484	DNA packaging
CG419_RS04050	COG3942	CHAP domain
CG419_RS04105	COG0393	Putative heavy-metal-binding
CG419_RS04110	COG3759	membrane
CG419_RS04115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG419_RS04120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG419_RS04120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG419_RS04125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG419_RS04130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG419_RS04135	COG4224	UPF0291 protein
CG419_RS04140	COG3763	UPF0154 protein
CG419_RS04145	COG1132	(ABC) transporter
CG419_RS04150	COG1132	(ABC) transporter
CG419_RS04155	COG1073	alpha beta
CG419_RS04160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG419_RS04165	COG0204	Acyl-transferase
CG419_RS04170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG419_RS04175	COG2827	Endonuclease containing a URI domain
CG419_RS04180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG419_RS04185	COG0052	Belongs to the universal ribosomal protein uS2 family
CG419_RS04190	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG419_RS04195	COG0528	UMP kinase activity
CG419_RS04200	COG0233	cytoplasmic translational termination
CG419_RS04210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CG419_RS04215	COG4589	Belongs to the CDS family
CG419_RS04220	COG0750	zinc metalloprotease
CG419_RS04225	COG0442	prolyl-tRNA aminoacylation
CG419_RS04230	COG2176	DNA-directed DNA polymerase activity
CG419_RS04250	COG1204	response to ionizing radiation
CG419_RS04265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG419_RS04275	COG0195	Participates in both transcription termination and antitermination
CG419_RS04280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG419_RS04290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG419_RS04295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG419_RS04315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG419_RS04320	COG0196	riboflavin kinase activity
CG419_RS04325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG419_RS04330	COG0110	maltose O-acetyltransferase activity
CG419_RS04340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG419_RS04345	COG0443	Heat shock 70 kDa protein
CG419_RS04360	COG0531	amino acid
CG419_RS04365	COG0561	phosphatase activity
CG419_RS04370	COG0745	RESPONSE REGULATOR receiver
CG419_RS04375	COG3850	Histidine kinase
CG419_RS04375	COG5002	protein histidine kinase activity
CG419_RS04380	COG0402	S-adenosylhomocysteine deaminase activity
CG419_RS04400	COG1368	sulfuric ester hydrolase activity
CG419_RS04415	COG4975	Glucose uptake
CG419_RS04420	COG4485	Bacterial membrane protein, YfhO
CG419_RS04425	COG2814	Major facilitator Superfamily
CG419_RS04435	COG2188	Transcriptional regulator
CG419_RS04445	COG0366	Alpha amylase catalytic
CG419_RS04450	COG2190	(PTS) system
CG419_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS04450	COG1263	PTS System
CG419_RS04455	COG3394	polysaccharide catabolic process
CG419_RS04495	COG1733	regulation of RNA biosynthetic process
CG419_RS04500	COG4221	oxidoreductase activity
CG419_RS04510	COG0028	Belongs to the TPP enzyme family
CG419_RS04515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CG419_RS04520	COG4120	Belongs to the binding-protein-dependent transport system permease family
CG419_RS04530	COG0166	Belongs to the GPI family
CG419_RS04560	COG4990	cell redox homeostasis
CG419_RS04570	COG0589	response to stress
CG419_RS04585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG419_RS04590	COG2723	6-phospho-beta-galactosidase activity
CG419_RS04600	COG3158	transport of potassium into the cell
CG419_RS04615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG419_RS04655	COG1803	Methylglyoxal synthase
CG419_RS04680	COG0577	efflux transmembrane transporter activity
CG419_RS04685	COG1136	(ABC) transporter
CG419_RS04705	COG1132	(ABC) transporter
CG419_RS04710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG419_RS04715	COG1482	cell wall glycoprotein biosynthetic process
CG419_RS04720	COG1418	mRNA catabolic process
CG419_RS04730	COG3442	glutamine amidotransferase
CG419_RS04735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG419_RS04740	COG1435	thymidine kinase activity
CG419_RS04745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG419_RS04750	COG2890	protein-(glutamine-N5) methyltransferase activity
CG419_RS04755	COG0009	L-threonylcarbamoyladenylate synthase
CG419_RS04760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG419_RS04765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG419_RS04770	COG0356	it plays a direct role in the translocation of protons across the membrane
CG419_RS04775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG419_RS04780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG419_RS04785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG419_RS04790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG419_RS04795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG419_RS04800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG419_RS04805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG419_RS04815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CG419_RS04830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG419_RS04840	COG0772	Belongs to the SEDS family
CG419_RS04845	COG0509	glycine decarboxylation via glycine cleavage system
CG419_RS04850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CG419_RS04855	COG2011	ABC-type metal ion transport system permease component
CG419_RS04860	COG1464	Belongs to the NlpA lipoprotein family
CG419_RS04870	COG1518	maintenance of DNA repeat elements
CG419_RS04890	COG0719	Fe-S assembly protein
CG419_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG419_RS04905	COG0719	Fe-S assembly protein
CG419_RS04960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG419_RS04975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG419_RS04985	COG4335	DNA alkylation repair
CG419_RS04990	COG0789	Transcriptional regulator
CG419_RS05000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG419_RS05005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG419_RS05010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG419_RS05015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG419_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
CG419_RS05035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG419_RS05040	COG0439	Biotin carboxylase
CG419_RS05045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG419_RS05055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CG419_RS05060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CG419_RS05060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CG419_RS05065	COG1268	BioY protein
CG419_RS05085	COG2096	Adenosyltransferase
CG419_RS05090	COG1956	GAF domain-containing protein
CG419_RS05115	COG5294	Protein conserved in bacteria
CG419_RS05125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG419_RS05145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG419_RS05160	COG4493	Belongs to the UPF0637 family
CG419_RS05165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG419_RS05170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG419_RS05175	COG1104	cysteine desulfurase activity
CG419_RS05180	COG0301	tRNA thio-modification
CG419_RS05185	COG0525	valine-tRNA ligase activity
CG419_RS05195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG419_RS05200	COG2003	Belongs to the UPF0758 family
CG419_RS05205	COG1077	Cell shape determining protein MreB Mrl
CG419_RS05210	COG1792	Involved in formation and maintenance of cell shape
CG419_RS05225	COG2894	cell division
CG419_RS05230	COG0765	amino acid transport
CG419_RS05235	COG1126	abc transporter atp-binding protein
CG419_RS05245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG419_RS05250	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG419_RS05250	COG4991	sh3 domain protein
CG419_RS05250	COG3103	Sh3 type 3 domain protein
CG419_RS05255	COG0124	histidyl-tRNA synthetase
CG419_RS05265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG419_RS05270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG419_RS05275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG419_RS05290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG419_RS05295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG419_RS05300	COG1610	YqeY-like protein
CG419_RS05305	COG1702	phosphate starvation-inducible protein PhoH
CG419_RS05310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG419_RS05325	COG1381	Involved in DNA repair and RecF pathway recombination
CG419_RS05330	COG0752	glycyl-tRNA synthetase alpha subunit
CG419_RS05335	COG0751	glycine-tRNA ligase activity
CG419_RS05340	COG3189	MarR family transcriptional regulator
CG419_RS05345	COG0358	DNA primase activity
CG419_RS05350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG419_RS05365	COG2384	SAM-dependent methyltransferase
CG419_RS05370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG419_RS05375	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG419_RS05380	COG0710	3-dehydroquinate dehydratase activity
CG419_RS05400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS05400	COG2190	(PTS) system
CG419_RS05400	COG1263	PTS System
CG419_RS05405	COG2188	Transcriptional regulator
CG419_RS05410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG419_RS05415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG419_RS05420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG419_RS05445	COG1942	4-Oxalocrotonate Tautomerase
CG419_RS05450	COG2378	regulation of single-species biofilm formation
CG419_RS05460	COG0561	phosphatase activity
CG419_RS05465	COG2151	metal-sulfur cluster biosynthetic enzyme
CG419_RS05480	COG1733	regulation of RNA biosynthetic process
CG419_RS05485	COG0604	alcohol dehydrogenase
CG419_RS05490	COG1304	FMN binding
CG419_RS05505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CG419_RS05510	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG419_RS05515	COG1074	ATP-dependent DNA helicase activity
CG419_RS05520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG419_RS05520	COG1199	ATP-dependent helicase activity
CG419_RS05530	COG0017	Asparaginyl-tRNA synthetase
CG419_RS05540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG419_RS05545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG419_RS05550	COG3331	DNA recombination
CG419_RS05555	COG4474	Belongs to the UPF0398 family
CG419_RS05560	COG3599	regulation of cell shape
CG419_RS05570	COG0116	Belongs to the methyltransferase superfamily
CG419_RS05575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG419_RS05580	COG0582	viral genome integration into host DNA
CG419_RS05600	COG2186	Transcriptional regulator
CG419_RS05605	COG1131	(ABC) transporter
CG419_RS05615	COG1131	(ABC) transporter
CG419_RS05635	COG0095	Lipoate-protein ligase
CG419_RS05640	COG3655	Transcriptional regulator
CG419_RS05675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG419_RS05690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG419_RS05695	COG0328	RNA-DNA hybrid ribonuclease activity
CG419_RS05705	COG1278	Cold shock
CG419_RS05710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CG419_RS05715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG419_RS05720	COG0564	pseudouridine synthase activity
CG419_RS05725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG419_RS05730	COG2233	PERMEase
CG419_RS05735	COG0540	Belongs to the ATCase OTCase family
CG419_RS05740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG419_RS05745	COG0505	Belongs to the CarA family
CG419_RS05750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG419_RS05755	COG0543	2 iron, 2 sulfur cluster binding
CG419_RS05760	COG0167	dihydroorotate dehydrogenase activity
CG419_RS05765	COG0284	orotidine-5'-phosphate decarboxylase activity
CG419_RS05775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CG419_RS05785	COG1307	EDD domain protein, DegV family
CG419_RS05795	COG1272	protein, Hemolysin III
CG419_RS05800	COG1307	EDD domain protein, DegV family
CG419_RS05805	COG1309	transcriptional regulator
CG419_RS05810	COG0604	alcohol dehydrogenase
CG419_RS05820	COG4974	Belongs to the 'phage' integrase family
CG419_RS05840	COG1227	inorganic diphosphatase activity
CG419_RS05845	COG0583	DNA-binding transcription factor activity
CG419_RS05850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG419_RS05860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG419_RS05865	COG0187	DNA topoisomerase II activity
CG419_RS05870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG419_RS05875	COG0390	transport system, permease component
CG419_RS05880	COG4619	ABC transporter
CG419_RS05885	COG0351	phosphomethylpyrimidine kinase
CG419_RS05890	COG3527	Alpha-acetolactate decarboxylase
CG419_RS05895	COG0028	Belongs to the TPP enzyme family
CG419_RS05905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG419_RS05920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG419_RS05925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG419_RS05930	COG1959	2 iron, 2 sulfur cluster binding
CG419_RS05935	COG0702	epimerase
CG419_RS05940	COG0758	DNA mediated transformation
CG419_RS05945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG419_RS05960	COG4479	Belongs to the UPF0346 family
CG419_RS05970	COG2755	lipolytic protein G-D-S-L family
CG419_RS05975	COG1307	EDD domain protein, DegV family
CG419_RS05985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG419_RS05990	COG0488	(ABC) transporter
CG419_RS06000	COG0617	tRNA 3'-terminal CCA addition
CG419_RS06005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG419_RS06010	COG2814	Major facilitator Superfamily
CG419_RS06030	COG0457	Tetratricopeptide repeat
CG419_RS06040	COG1160	GTP binding
CG419_RS06045	COG0539	negative regulation of cytoplasmic translation
CG419_RS06050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG419_RS06060	COG0514	ATP-dependent DNA helicase (RecQ)
CG419_RS06070	COG1141	Ferredoxin
CG419_RS06075	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG419_RS06080	COG1187	pseudouridine synthase activity
CG419_RS06085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG419_RS06090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG419_RS06105	COG0735	belongs to the Fur family
CG419_RS06110	COG2996	Protein conserved in bacteria
CG419_RS06115	COG2707	UPF0756 membrane protein
CG419_RS06130	COG0587	DNA-directed DNA polymerase activity
CG419_RS06145	COG0531	amino acid
CG419_RS06155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CG419_RS06160	COG0542	response to heat
CG419_RS06165	COG5416	Lipopolysaccharide assembly protein A domain
CG419_RS06170	COG0300	oxidoreductase activity
CG419_RS06175	COG1234	tRNA 3'-trailer cleavage
CG419_RS06185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CG419_RS06195	COG1349	DNA-binding transcription factor activity
CG419_RS06200	COG1105	Belongs to the carbohydrate kinase PfkB family
CG419_RS06205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS06205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS06205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS06210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG419_RS06215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG419_RS06220	COG1846	Transcriptional regulator
CG419_RS06230	COG1621	beta-fructofuranosidase activity
CG419_RS06235	COG2190	(PTS) system
CG419_RS06235	COG1263	PTS System
CG419_RS06235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS06240	COG0366	Alpha amylase catalytic
CG419_RS06245	COG1609	Transcriptional regulator
CG419_RS06250	COG0322	excinuclease ABC activity
CG419_RS06260	COG0765	amino acid transport
CG419_RS06270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG419_RS06275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG419_RS06280	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG419_RS06285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG419_RS06300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CG419_RS06305	COG0268	Binds directly to 16S ribosomal RNA
CG419_RS06315	COG1466	dna polymerase III delta subunit
CG419_RS06320	COG2333	competence protein COMEC
CG419_RS06320	COG0658	competence protein
CG419_RS06325	COG2131	deaminase
CG419_RS06330	COG1555	photosystem II stabilization
CG419_RS06330	COG1596	polysaccharide export
CG419_RS06335	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG419_RS06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG419_RS06345	COG0742	ribosomal rna small subunit methyltransferase
CG419_RS06350	COG4471	UPF0298 protein
CG419_RS06360	COG0772	Belongs to the SEDS family
CG419_RS06365	COG4838	Belongs to the UPF0358 family
CG419_RS06370	COG1217	gtp-binding protein TYPA
CG419_RS06375	COG0483	inositol monophosphate 1-phosphatase activity
CG419_RS06380	COG4476	Belongs to the UPF0223 family
CG419_RS06410	COG0242	peptide deformylase activity
CG419_RS06430	COG5503	Protein of unknown function (DUF1447)
CG419_RS06440	COG1597	lipid kinase activity
CG419_RS06450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG419_RS06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CG419_RS06470	COG0482	sulfurtransferase activity
CG419_RS06480	COG1104	cysteine desulfurase activity
CG419_RS06485	COG1606	tRNA processing
CG419_RS06495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG419_RS06500	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CG419_RS06505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CG419_RS06510	COG1691	(AIR) carboxylase
CG419_RS06515	COG3875	lactate racemase activity
CG419_RS06520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG419_RS06525	COG0310	cobalt ion transport
CG419_RS06530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG419_RS06535	COG1122	ATPase activity
CG419_RS06540	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG419_RS06555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG419_RS06565	COG0494	nUDIX hydrolase
CG419_RS06580	COG2814	Major facilitator Superfamily
CG419_RS06585	COG1757	Na H antiporter
CG419_RS06590	COG1113	amino acid transport
CG419_RS06600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG419_RS06615	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CG419_RS06620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG419_RS06630	COG1609	Transcriptional regulator
CG419_RS06635	COG2271	Major facilitator Superfamily
CG419_RS06640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG419_RS06665	COG2115	Belongs to the xylose isomerase family
CG419_RS06670	COG3507	Belongs to the glycosyl hydrolase 43 family
CG419_RS06675	COG2211	Major facilitator Superfamily
CG419_RS06690	COG2017	converts alpha-aldose to the beta-anomer
CG419_RS06700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG419_RS06705	COG3599	regulation of cell shape
CG419_RS06710	COG2302	S4 RNA-binding domain
CG419_RS06720	COG1799	cell septum assembly
CG419_RS06740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG419_RS06745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG419_RS06750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG419_RS06755	COG0768	penicillin binding
CG419_RS06765	COG0275	rRNA processing
CG419_RS06770	COG2001	Belongs to the MraZ family
CG419_RS06790	COG1490	D-aminoacyl-tRNA deacylase activity
CG419_RS06795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG419_RS06805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG419_RS06810	COG2264	protein methyltransferase activity
CG419_RS06825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG419_RS06860	COG0335	large ribosomal subunit rRNA binding
CG419_RS06865	COG0336	Belongs to the RNA methyltransferase TrmD family
CG419_RS06870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG419_RS06875	COG1837	Belongs to the UPF0109 family
CG419_RS06880	COG0228	four-way junction DNA binding
CG419_RS06885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG419_RS06890	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG419_RS06900	COG1929	Belongs to the glycerate kinase type-1 family
CG419_RS06905	COG0552	protein localization to endoplasmic reticulum
CG419_RS06910	COG1196	nuclear chromosome segregation
CG419_RS06915	COG0571	ribonuclease III activity
CG419_RS06920	COG4608	Belongs to the ABC transporter superfamily
CG419_RS06925	COG0444	Belongs to the ABC transporter superfamily
CG419_RS06930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG419_RS06935	COG0601	transmembrane transport
CG419_RS06940	COG4166	transmembrane transport
CG419_RS06945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG419_RS06950	COG0416	fatty acid biosynthetic process
CG419_RS06955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG419_RS06960	COG1461	Dihydroxyacetone kinase
CG419_RS06965	COG1302	Protein conserved in bacteria
CG419_RS06970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG419_RS06975	COG1564	THIamine pyrophosphokinase
CG419_RS06980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG419_RS06985	COG1162	GTPase activity
CG419_RS06990	COG0515	serine threonine protein kinase
CG419_RS06990	COG2815	serine threonine protein kinase
CG419_RS07000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG419_RS07000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG419_RS07005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG419_RS07010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG419_RS07015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG419_RS07020	COG1758	RNA polymerase activity
CG419_RS07025	COG0194	GDP metabolic process
CG419_RS07040	COG0497	DNA recombination
CG419_RS07045	COG1438	arginine binding
CG419_RS07050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG419_RS07060	COG1722	exodeoxyribonuclease VII activity
CG419_RS07065	COG1570	exodeoxyribonuclease VII activity
CG419_RS07070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG419_RS07075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG419_RS07080	COG1302	Protein conserved in bacteria
CG419_RS07085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG419_RS07090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG419_RS07100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CG419_RS07115	COG1304	FMN binding
CG419_RS07120	COG0151	Belongs to the GarS family
CG419_RS07125	COG0138	bifunctional purine biosynthesis protein purh
CG419_RS07130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG419_RS07135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG419_RS07145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG419_RS07150	COG0047	phosphoribosylformylglycinamidine synthase activity
CG419_RS07155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG419_RS07160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG419_RS07175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG419_RS07180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG419_RS07185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG419_RS07190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG419_RS07205	COG1278	Cold shock
CG419_RS07210	COG1694	Mazg nucleotide pyrophosphohydrolase
CG419_RS07220	COG2936	dipeptidyl-peptidase activity
CG419_RS07225	COG1607	acyl-coa hydrolase
CG419_RS07240	COG0670	Belongs to the BI1 family
CG419_RS07245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG419_RS07250	COG0367	asparagine synthase
CG419_RS07255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG419_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG419_RS07270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG419_RS07275	COG0510	thiamine kinase activity
CG419_RS07285	COG1131	(ABC) transporter
CG419_RS07290	COG0537	adenosine 5'-monophosphoramidase activity
CG419_RS07300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CG419_RS07305	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG419_RS07315	COG0420	3'-5' exonuclease activity
CG419_RS07320	COG3679	Belongs to the UPF0342 family
CG419_RS07325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG419_RS07330	COG0564	pseudouridine synthase activity
CG419_RS07340	COG1438	arginine binding
CG419_RS07345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS07345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS07345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS07355	COG3711	transcriptional antiterminator
CG419_RS07355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS07380	COG0346	lactoylglutathione lyase activity
CG419_RS07385	COG0148	phosphopyruvate hydratase activity
CG419_RS07390	COG0149	triose-phosphate isomerase activity
CG419_RS07395	COG0126	phosphoglycerate kinase activity
CG419_RS07405	COG2390	Transcriptional regulator
CG419_RS07420	COG0584	glycerophosphoryl diester phosphodiesterase
CG419_RS07425	COG0446	pyridine nucleotide-disulphide oxidoreductase
CG419_RS07465	COG3279	Response regulator of the LytR AlgR family
CG419_RS07470	COG3290	protein histidine kinase activity
CG419_RS07490	COG1764	response to oxidative stress
CG419_RS07495	COG4977	sequence-specific DNA binding
CG419_RS07510	COG4166	transmembrane transport
CG419_RS07520	COG2197	response regulator
CG419_RS07525	COG4585	Histidine kinase
CG419_RS07530	COG0842	Transport permease protein
CG419_RS07535	COG1131	(ABC) transporter
CG419_RS07540	COG2094	Belongs to the DNA glycosylase MPG family
CG419_RS07555	COG0604	alcohol dehydrogenase
CG419_RS07575	COG1957	nucleoside hydrolase
CG419_RS07585	COG1472	Belongs to the glycosyl hydrolase 3 family
CG419_RS07590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS07595	COG0740	serine-type endopeptidase activity
CG419_RS07610	COG1481	regulation of sporulation
CG419_RS07615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG419_RS07620	COG1660	Displays ATPase and GTPase activities
CG419_RS07630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG419_RS07635	COG0556	nucleotide-excision repair
CG419_RS07645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG419_RS07650	COG0492	ferredoxin-NADP+ reductase activity
CG419_RS07660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG419_RS07665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG419_RS07670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG419_RS07675	COG1950	PFAM Membrane protein of
CG419_RS07685	COG1983	PspC domain protein
CG419_RS07700	COG0704	Plays a role in the regulation of phosphate uptake
CG419_RS07705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG419_RS07710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG419_RS07715	COG0581	inorganic phosphate transmembrane transporter activity
CG419_RS07720	COG0573	inorganic phosphate transmembrane transporter activity
CG419_RS07730	COG5002	protein histidine kinase activity
CG419_RS07735	COG0745	RESPONSE REGULATOR receiver
CG419_RS07745	COG2177	Part of the ABC transporter FtsEX involved in
CG419_RS07750	COG2884	Cell division ATP-binding protein ftsE
CG419_RS07760	COG0653	protein targeting
CG419_RS07770	COG1040	competence protein
CG419_RS07775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG419_RS07780	COG1739	Uncharacterized protein family UPF0029
CG419_RS07785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG419_RS07790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CG419_RS07795	COG1418	mRNA catabolic process
CG419_RS07800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG419_RS07805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG419_RS07810	COG1426	Protein conserved in bacteria
CG419_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
CG419_RS07820	COG0612	Peptidase, M16
CG419_RS07825	COG0612	Peptidase, M16
CG419_RS07830	COG1674	ftsk spoiiie
CG419_RS07845	COG2226	methyltransferase
CG419_RS07855	COG0516	GMP reductase activity
CG419_RS07860	COG2153	protein acetylation
CG419_RS07865	COG0628	permease
CG419_RS07875	COG2706	6-phosphogluconolactonase activity
CG419_RS07880	COG0477	Major facilitator Superfamily
CG419_RS07885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG419_RS07935	COG0735	belongs to the Fur family
CG419_RS07940	COG1368	sulfuric ester hydrolase activity
CG419_RS07950	COG2084	Dehydrogenase
CG419_RS07960	COG0438	transferase activity, transferring glycosyl groups
CG419_RS07975	COG0730	response to heat
CG419_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
CG419_RS08005	COG3716	PTS system mannose fructose sorbose family IID component
CG419_RS08010	COG3715	PTS system
CG419_RS08025	COG1011	Hydrolase
CG419_RS08030	COG0167	dihydroorotate dehydrogenase activity
CG419_RS08055	COG0251	oxidation-reduction process
CG419_RS08065	COG0281	malic enzyme
CG419_RS08070	COG0583	DNA-binding transcription factor activity
CG419_RS08080	COG0583	DNA-binding transcription factor activity
CG419_RS08270	COG1098	S1 RNA binding domain
CG419_RS08275	COG1940	carbohydrate kinase activity
CG419_RS08280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG419_RS08285	COG0492	ferredoxin-NADP+ reductase activity
CG419_RS08290	COG0586	Pfam SNARE associated Golgi protein
CG419_RS08300	COG0647	UMP catabolic process
CG419_RS08305	COG4470	Protein conserved in bacteria
CG419_RS08310	COG0737	Belongs to the 5'-nucleotidase family
CG419_RS08330	COG0640	Transcriptional regulator
CG419_RS08335	COG2217	Heavy metal translocating P-type atpase
CG419_RS08350	COG2814	Major facilitator Superfamily
CG419_RS08365	COG0363	glucosamine-6-phosphate deaminase activity
CG419_RS08370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG419_RS08375	COG1609	Transcriptional regulator
CG419_RS08380	COG0006	proline dipeptidase activity
CG419_RS08395	COG0668	transmembrane transport
CG419_RS08440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CG419_RS08445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CG419_RS08450	COG1719	4-vinyl reductase, 4VR
CG419_RS08455	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG419_RS08460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG419_RS08465	COG1696	Membrane protein involved in D-alanine export
CG419_RS08470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG419_RS08480	COG3118	belongs to the thioredoxin family
CG419_RS08485	COG1193	negative regulation of DNA recombination
CG419_RS08490	COG1286	toxin biosynthetic process
CG419_RS08495	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG419_RS08500	COG3906	Belongs to the UPF0473 family
CG419_RS08505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG419_RS08510	COG4472	Bacterial protein of unknown function (DUF965)
CG419_RS08515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG419_RS08525	COG0513	Belongs to the DEAD box helicase family
CG419_RS08530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG419_RS08535	COG4109	DRTGG domain
CG419_RS08540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG419_RS08545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CG419_RS08550	COG1321	iron dependent repressor
CG419_RS08555	COG1454	alcohol dehydrogenase
CG419_RS08555	COG1012	belongs to the aldehyde dehydrogenase family
CG419_RS08560	COG1862	Preprotein translocase
CG419_RS08565	COG0343	queuine tRNA-ribosyltransferase activity
CG419_RS08575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG419_RS08580	COG2255	four-way junction helicase activity
CG419_RS08585	COG0632	four-way junction helicase activity
CG419_RS08595	COG0424	maF-like protein
CG419_RS08605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG419_RS08610	COG1692	metallophosphoesterase
CG419_RS08615	COG0531	amino acid
CG419_RS08625	COG0459	protein refolding
CG419_RS08630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG419_RS08635	COG1266	CAAX protease self-immunity
CG419_RS08645	COG0488	(ABC) transporter
CG419_RS08655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS08665	COG3688	RNA-binding protein containing a PIN domain
CG419_RS08670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG419_RS08675	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CG419_RS08680	COG0215	cysteine-tRNA ligase activity
CG419_RS08685	COG4956	integral membrane protein (PIN domain superfamily)
CG419_RS08690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG419_RS08695	COG0756	dUTP diphosphatase activity
CG419_RS08720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS08730	COG2188	Transcriptional regulator
CG419_RS08735	COG1446	asparaginase
CG419_RS08780	COG1285	pathogenesis
CG419_RS08785	COG1914	H( )-stimulated, divalent metal cation uptake system
CG419_RS08790	COG2610	gluconate transmembrane transporter activity
CG419_RS08795	COG1070	Carbohydrate kinase
CG419_RS08800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG419_RS08805	COG1737	Transcriptional regulator
CG419_RS08810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG419_RS08820	COG2188	Transcriptional regulator
CG419_RS08840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG419_RS08850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG419_RS08855	COG1316	TRANSCRIPTIONal
CG419_RS08870	COG1121	(ABC) transporter
CG419_RS08885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG419_RS08890	COG1686	Belongs to the peptidase S11 family
CG419_RS08895	COG5002	protein histidine kinase activity
CG419_RS08905	COG0517	IMP dehydrogenase activity
CG419_RS08905	COG0516	GMP reductase activity
CG419_RS08910	COG2365	Tyrosine phosphatase family
CG419_RS08915	COG2814	Major facilitator Superfamily
CG419_RS08920	COG0383	alpha-mannosidase activity
CG419_RS08930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS08935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS08935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS08935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS08945	COG1079	Belongs to the binding-protein-dependent transport system permease family
CG419_RS08950	COG4603	Belongs to the binding-protein-dependent transport system permease family
CG419_RS08955	COG3845	ABC transporter
CG419_RS08960	COG1744	ABC transporter substrate-binding protein PnrA-like
CG419_RS08970	COG3973	AAA domain
CG419_RS08975	COG1132	(ABC) transporter
CG419_RS08980	COG1132	(ABC) transporter
CG419_RS08990	COG2814	Major facilitator Superfamily
CG419_RS08995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CG419_RS09000	COG1695	Transcriptional regulator
CG419_RS09005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG419_RS09015	COG0667	Aldo Keto reductase
CG419_RS09020	COG1957	nucleoside hydrolase
CG419_RS09050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CG419_RS09115	COG2378	regulation of single-species biofilm formation
CG419_RS09150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG419_RS09205	COG1914	H( )-stimulated, divalent metal cation uptake system
CG419_RS09245	COG3942	CHAP domain
CG419_RS09260	COG1215	transferase activity, transferring glycosyl groups
CG419_RS09275	COG0789	Transcriptional regulator
CG419_RS09280	COG0656	L-ascorbic acid biosynthetic process
CG419_RS09300	COG1132	(ABC) transporter
CG419_RS09315	COG2190	(PTS) system
CG419_RS09315	COG1263	PTS System
CG419_RS09315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS09320	COG2723	6-phospho-beta-galactosidase activity
CG419_RS09325	COG2723	6-phospho-beta-galactosidase activity
CG419_RS09335	COG0561	phosphatase activity
CG419_RS09345	COG4221	oxidoreductase activity
CG419_RS09350	COG0110	maltose O-acetyltransferase activity
CG419_RS09355	COG0583	DNA-binding transcription factor activity
CG419_RS09365	COG3118	belongs to the thioredoxin family
CG419_RS09370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG419_RS09385	COG0446	pyridine nucleotide-disulphide oxidoreductase
CG419_RS09405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS09470	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CG419_RS09520	COG1063	alcohol dehydrogenase
CG419_RS09530	COG1917	Cupin 2, conserved barrel domain protein
CG419_RS09530	COG4977	sequence-specific DNA binding
CG419_RS09545	COG2826	transposase and inactivated derivatives, IS30 family
CG419_RS09550	COG3321	synthase
CG419_RS09550	COG0604	alcohol dehydrogenase
CG419_RS09550	COG4221	oxidoreductase activity
CG419_RS09550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG419_RS09555	COG0583	DNA-binding transcription factor activity
CG419_RS09560	COG0656	L-ascorbic acid biosynthetic process
CG419_RS09565	COG4221	oxidoreductase activity
CG419_RS09585	COG0588	phosphoglycerate mutase activity
CG419_RS09590	COG0477	Major facilitator Superfamily
CG419_RS09605	COG1879	ABC-type sugar transport system periplasmic component
CG419_RS09610	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG419_RS09625	COG1609	Transcriptional regulator
CG419_RS09635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG419_RS09670	COG0531	amino acid
CG419_RS09675	COG0488	(ABC) transporter
CG419_RS09680	COG1316	TRANSCRIPTIONal
CG419_RS09685	COG1216	Glycosyl transferase, family 2
CG419_RS09690	COG2190	(PTS) system
CG419_RS09690	COG2211	Major facilitator Superfamily
CG419_RS09720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG419_RS09725	COG1737	Transcriptional regulator
CG419_RS09730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG419_RS09750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS09755	COG0191	fructose-bisphosphate aldolase activity
CG419_RS09770	COG1105	Belongs to the carbohydrate kinase PfkB family
CG419_RS09775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS09775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09780	COG3684	Belongs to the aldolase LacD family
CG419_RS09785	COG4690	dipeptidase activity
CG419_RS09840	COG1302	Protein conserved in bacteria
CG419_RS09855	COG2261	transglycosylase associated protein
CG419_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
CG419_RS09875	COG1442	glycosyl transferase family 8
CG419_RS09885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG419_RS09890	COG1121	(ABC) transporter
CG419_RS09895	COG0383	alpha-mannosidase activity
CG419_RS09900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS09900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS09910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG419_RS09915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG419_RS09915	COG3711	transcriptional antiterminator
CG419_RS09925	COG2723	6-phospho-beta-galactosidase activity
CG419_RS09930	COG2190	(PTS) system
CG419_RS09930	COG1263	PTS System
CG419_RS09930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG419_RS09980	COG0519	Catalyzes the synthesis of GMP from XMP
CG419_RS09985	COG1072	(Pantothenic acid kinase))
CG419_RS09990	COG5617	Psort location CytoplasmicMembrane, score
CG419_RS09995	COG3973	AAA domain
CG419_RS10000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG419_RS10005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG419_RS10010	COG0569	domain protein
CG419_RS10010	COG0475	glutathione-regulated potassium exporter activity
CG419_RS10015	COG2267	carboxylic ester hydrolase activity
CG419_RS10035	COG1136	(ABC) transporter
CG419_RS10040	COG0531	amino acid
CG419_RS10045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG419_RS10050	COG1554	hydrolase, family 65, central catalytic
CG419_RS10055	COG3842	ATPase activity
CG419_RS10060	COG0366	Alpha amylase catalytic
CG419_RS10070	COG0366	Alpha amylase catalytic
CG419_RS10075	COG3833	ABC-type maltose transport systems, permease component
CG419_RS10080	COG1175	transmembrane transport
CG419_RS10090	COG1609	Transcriptional regulator
CG419_RS10120	COG0531	amino acid
CG419_RS10125	COG1940	carbohydrate kinase activity
CG419_RS10135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG419_RS10170	COG0735	belongs to the Fur family
CG419_RS10180	COG0194	GDP metabolic process
CG419_RS10195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG419_RS10215	COG0588	phosphoglycerate mutase activity
CG419_RS10220	COG0681	Belongs to the peptidase S26 family
CG419_RS10225	COG1288	antiporter activity
CG419_RS10230	COG2814	Major facilitator Superfamily
CG419_RS10245	COG0697	spore germination
CG419_RS10265	COG0488	(ABC) transporter
CG419_RS10275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG419_RS10300	COG0706	membrane insertase activity
CG419_RS10305	COG0594	ribonuclease P activity
CG419_RS10310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CG419_RS10395	COG0745	RESPONSE REGULATOR receiver