locus-tag	class	description
IY73_RS00005	COG1716	ATPase activity
IY73_RS00030	COG1253	flavin adenine dinucleotide binding
IY73_RS00035	COG1253	flavin adenine dinucleotide binding
IY73_RS00065	COG0463	Glycosyl transferase, family 2
IY73_RS00100	COG0300	oxidoreductase activity
IY73_RS00115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IY73_RS00130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IY73_RS00170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IY73_RS00175	COG0646	methionine synthase
IY73_RS00175	COG1410	methionine synthase
IY73_RS00180	COG0215	cysteine-tRNA ligase activity
IY73_RS00195	COG0167	dihydroorotate dehydrogenase activity
IY73_RS00210	COG0398	Pfam SNARE associated Golgi protein
IY73_RS00225	COG0791	NLP P60 protein
IY73_RS00225	COG3883	PFAM NLP P60 protein
IY73_RS00235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IY73_RS00240	COG0488	(ABC) transporter
IY73_RS00250	COG2151	metal-sulfur cluster biosynthetic enzyme
IY73_RS00255	COG0822	iron-sulfur transferase activity
IY73_RS00260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IY73_RS00265	COG0396	ATPase activity
IY73_RS00295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IY73_RS00300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IY73_RS00305	COG0149	triose-phosphate isomerase activity
IY73_RS00310	COG0126	phosphoglycerate kinase activity
IY73_RS00320	COG1481	regulation of sporulation
IY73_RS00330	COG0322	excinuclease ABC activity
IY73_RS00335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IY73_RS00340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IY73_RS00340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IY73_RS00345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IY73_RS00345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IY73_RS00370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IY73_RS00375	COG0242	peptide deformylase activity
IY73_RS00390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IY73_RS00400	COG0194	GDP metabolic process
IY73_RS00410	COG0284	orotidine-5'-phosphate decarboxylase activity
IY73_RS00420	COG0505	Belongs to the CarA family
IY73_RS00430	COG0540	Belongs to the ATCase OTCase family
IY73_RS00435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IY73_RS00445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IY73_RS00450	COG0006	proline dipeptidase activity
IY73_RS00460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IY73_RS00465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IY73_RS00470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IY73_RS00475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IY73_RS00485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IY73_RS00490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IY73_RS00520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IY73_RS00525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IY73_RS00530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IY73_RS00535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IY73_RS00540	COG0747	negative chemotaxis
IY73_RS00545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IY73_RS00565	COG0632	four-way junction helicase activity
IY73_RS00570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IY73_RS00580	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IY73_RS00585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IY73_RS00595	COG0438	transferase activity, transferring glycosyl groups
IY73_RS00655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IY73_RS00660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IY73_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IY73_RS00675	COG0569	domain protein
IY73_RS00700	COG0756	dUTP diphosphatase activity
IY73_RS00715	COG0674	pyruvate-flavodoxin oxidoreductase activity
IY73_RS00720	COG1013	pyruvate-flavodoxin oxidoreductase activity
IY73_RS00725	COG0493	'glutamate synthase
IY73_RS00725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IY73_RS00730	COG0483	inositol monophosphate 1-phosphatase activity
IY73_RS00750	COG2264	protein methyltransferase activity
IY73_RS00760	COG1321	iron dependent repressor
IY73_RS00795	COG4221	oxidoreductase activity
IY73_RS00810	COG1472	Belongs to the glycosyl hydrolase 3 family
IY73_RS00815	COG1472	Belongs to the glycosyl hydrolase 3 family
IY73_RS00820	COG1472	Belongs to the glycosyl hydrolase 3 family
IY73_RS00825	COG1643	Atp-dependent helicase
IY73_RS00830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IY73_RS00835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IY73_RS00840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IY73_RS00845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IY73_RS00845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IY73_RS00855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IY73_RS00860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IY73_RS00865	COG1414	Transcriptional regulator
IY73_RS00870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IY73_RS00875	COG1196	nuclear chromosome segregation
IY73_RS00880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IY73_RS00885	COG2137	regulation of response to DNA damage stimulus
IY73_RS00895	COG1268	BioY protein
IY73_RS00900	COG1122	ATPase activity
IY73_RS00910	COG1842	Phage shock protein A
IY73_RS00915	COG1396	sequence-specific DNA binding
IY73_RS00925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IY73_RS00940	COG1674	ftsk spoiiie
IY73_RS00945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IY73_RS00950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IY73_RS00955	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IY73_RS00960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IY73_RS00965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IY73_RS00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IY73_RS01015	COG0534	Mate efflux family protein
IY73_RS01020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IY73_RS01025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IY73_RS01030	COG0738	Major facilitator superfamily
IY73_RS01040	COG0481	GTPase activity
IY73_RS01050	COG0779	Required for maturation of 30S ribosomal subunits
IY73_RS01065	COG0442	prolyl-tRNA aminoacylation
IY73_RS01120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IY73_RS01125	COG0750	zinc metalloprotease
IY73_RS01130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IY73_RS01145	COG0575	Belongs to the CDS family
IY73_RS01155	COG0528	UMP kinase activity
IY73_RS01160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IY73_RS01165	COG0052	Belongs to the universal ribosomal protein uS2 family
IY73_RS01175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IY73_RS01195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IY73_RS01200	COG0681	Belongs to the peptidase S26 family
IY73_RS01210	COG0336	Belongs to the RNA methyltransferase TrmD family
IY73_RS01215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IY73_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
IY73_RS01250	COG1196	nuclear chromosome segregation
IY73_RS01260	COG0571	ribonuclease III activity
IY73_RS01275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IY73_RS01280	COG0742	ribosomal rna small subunit methyltransferase
IY73_RS01305	COG1181	Belongs to the D-alanine--D-alanine ligase family
IY73_RS01325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IY73_RS01335	COG1278	Cold shock
IY73_RS01350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IY73_RS01360	COG0179	Fumarylacetoacetate (FAA) hydrolase
IY73_RS01375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IY73_RS01385	COG0028	Belongs to the TPP enzyme family
IY73_RS01390	COG0129	dihydroxy-acid dehydratase activity
IY73_RS01405	COG0205	6-phosphofructokinase activity
IY73_RS01410	COG0154	amidase activity
IY73_RS01415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IY73_RS01425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IY73_RS01440	COG0482	sulfurtransferase activity
IY73_RS01450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IY73_RS01455	COG2086	electron transfer activity
IY73_RS01460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IY73_RS01480	COG0110	maltose O-acetyltransferase activity
IY73_RS01495	COG1119	ATPase activity
IY73_RS01510	COG0366	Alpha amylase catalytic
IY73_RS01515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IY73_RS01520	COG3118	belongs to the thioredoxin family
IY73_RS01525	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IY73_RS01545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IY73_RS01555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IY73_RS01560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IY73_RS01565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IY73_RS01570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IY73_RS01575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IY73_RS01580	COG0356	it plays a direct role in the translocation of protons across the membrane
IY73_RS01605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IY73_RS01615	COG0083	homoserine kinase activity
IY73_RS01620	COG0460	homoserine dehydrogenase
IY73_RS01625	COG0019	diaminopimelate decarboxylase activity
IY73_RS01630	COG0018	arginyl-trna synthetase
IY73_RS01645	COG0420	3'-5' exonuclease activity
IY73_RS01655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IY73_RS01670	COG2814	Major facilitator Superfamily
IY73_RS01675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IY73_RS01685	COG0567	Dehydrogenase, E1 component
IY73_RS01685	COG0508	dehydrogenase complex catalyzes the overall conversion of
IY73_RS01715	COG1477	protein flavinylation
IY73_RS01720	COG2239	Acts as a magnesium transporter
IY73_RS01735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IY73_RS01740	COG5662	AntiSigma factor
IY73_RS01745	COG1595	DNA-templated transcription, initiation
IY73_RS01755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IY73_RS01760	COG0297	glycogen (starch) synthase activity
IY73_RS01765	COG2226	methyltransferase
IY73_RS01775	COG0463	Glycosyl transferase, family 2
IY73_RS01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IY73_RS01795	COG1113	amino acid transport
IY73_RS01810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IY73_RS01820	COG1217	gtp-binding protein TYPA
IY73_RS01825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IY73_RS01830	COG0114	fumarate hydratase activity
IY73_RS01840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IY73_RS01855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IY73_RS01865	COG1063	alcohol dehydrogenase
IY73_RS01870	COG0012	GTP binding
IY73_RS01875	COG0733	neurotransmitter:sodium symporter activity
IY73_RS01880	COG0733	neurotransmitter:sodium symporter activity
IY73_RS01900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IY73_RS01920	COG1494	fructose-1,6-bisphosphatase
IY73_RS01930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IY73_RS01935	COG1072	(Pantothenic acid kinase))
IY73_RS01945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IY73_RS01950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IY73_RS01985	COG0148	phosphopyruvate hydratase activity
IY73_RS01995	COG3956	TIGRFAM MazG family protein
IY73_RS02005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IY73_RS02015	COG1045	serine acetyltransferase
IY73_RS02025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IY73_RS02055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IY73_RS02060	COG3104	oligopeptide transport
IY73_RS02070	COG1024	Enoyl-CoA hydratase
IY73_RS02080	COG0488	(ABC) transporter
IY73_RS02085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IY73_RS02090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IY73_RS02095	COG3583	domain protein
IY73_RS02100	COG0084	hydrolase, TatD family'
IY73_RS02105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IY73_RS02125	COG1132	(ABC) transporter
IY73_RS02135	COG1309	transcriptional regulator
IY73_RS02165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IY73_RS02170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IY73_RS02190	COG0521	Mo-molybdopterin cofactor biosynthetic process
IY73_RS02195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IY73_RS02200	COG2205	protein histidine kinase activity
IY73_RS02205	COG0745	RESPONSE REGULATOR receiver
IY73_RS02215	COG0254	rRNA binding
IY73_RS02220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IY73_RS02230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IY73_RS02235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IY73_RS02280	COG1605	Chorismate mutase
IY73_RS02285	COG0166	Belongs to the GPI family
IY73_RS02290	COG1218	3'(2'),5'-bisphosphate nucleotidase
IY73_RS02335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IY73_RS02340	COG2966	Psort location CytoplasmicMembrane, score
IY73_RS02365	COG0372	Belongs to the citrate synthase family
IY73_RS02370	COG2017	converts alpha-aldose to the beta-anomer
IY73_RS02405	COG1278	Cold shock
IY73_RS02410	COG1652	LysM domain
IY73_RS02445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IY73_RS02450	COG2197	response regulator
IY73_RS02455	COG0523	cobalamin synthesis protein
IY73_RS02485	COG0587	DNA-directed DNA polymerase activity
IY73_RS02525	COG0516	GMP reductase activity
IY73_RS02555	COG0459	protein refolding
IY73_RS02560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IY73_RS02575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IY73_RS02580	COG0456	acetyltransferase
IY73_RS02585	COG0456	acetyltransferase
IY73_RS02585	COG1214	PFAM Peptidase M22, glycoprotease
IY73_RS02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IY73_RS02595	COG0433	COG0433 Predicted ATPase
IY73_RS02610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IY73_RS02635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IY73_RS02640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IY73_RS02645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IY73_RS02665	COG1674	ftsk spoiiie
IY73_RS02675	COG1404	Belongs to the peptidase S8 family
IY73_RS02705	COG0203	ribosomal protein L17
IY73_RS02720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IY73_RS02730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IY73_RS02740	COG0563	adenylate kinase activity
IY73_RS02745	COG0201	protein transport
IY73_RS02755	COG1841	ribosomal large subunit assembly
IY73_RS02765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IY73_RS02770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IY73_RS02785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IY73_RS02790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IY73_RS02800	COG1070	Carbohydrate kinase
IY73_RS02810	COG0255	Belongs to the universal ribosomal protein uL29 family
IY73_RS02825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IY73_RS02830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IY73_RS02835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IY73_RS02840	COG0089	rRNA binding
IY73_RS02845	COG0088	Forms part of the polypeptide exit tunnel
IY73_RS02855	COG0051	transcription antitermination factor activity, RNA binding
IY73_RS02860	COG1302	Protein conserved in bacteria
IY73_RS02890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IY73_RS02915	COG1785	Belongs to the alkaline phosphatase family
IY73_RS02930	COG0085	RNA polymerase activity
IY73_RS02950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IY73_RS02995	COG0142	geranyltranstransferase activity
IY73_RS03000	COG2226	methyltransferase
IY73_RS03010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IY73_RS03020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IY73_RS03025	COG4948	Mandelate Racemase Muconate Lactonizing
IY73_RS03065	COG0406	alpha-ribazole phosphatase activity
IY73_RS03090	COG0113	porphobilinogen synthase activity
IY73_RS03100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IY73_RS03130	COG0745	RESPONSE REGULATOR receiver
IY73_RS03135	COG5002	protein histidine kinase activity
IY73_RS03140	COG0588	phosphoglycerate mutase activity
IY73_RS03145	COG0438	transferase activity, transferring glycosyl groups
IY73_RS03150	COG0318	PFAM AMP-dependent synthetase and ligase
IY73_RS03160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IY73_RS03175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IY73_RS03180	COG0788	formyltetrahydrofolate deformylase activity
IY73_RS03190	COG2733	membrane
IY73_RS03205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IY73_RS03210	COG1053	succinate dehydrogenase
IY73_RS03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IY73_RS03260	COG0459	protein refolding
IY73_RS03295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IY73_RS03315	COG2326	polyphosphate kinase activity
IY73_RS03325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IY73_RS03335	COG1131	(ABC) transporter
IY73_RS03340	COG2022	thiamine diphosphate biosynthetic process
IY73_RS03355	COG0352	thiamine-phosphate diphosphorylase activity
IY73_RS03365	COG0515	serine threonine protein kinase
IY73_RS03370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IY73_RS03395	COG0693	protein deglycase activity
IY73_RS03415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IY73_RS03425	COG1396	sequence-specific DNA binding
IY73_RS03450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IY73_RS03470	COG0343	queuine tRNA-ribosyltransferase activity
IY73_RS03490	COG0590	tRNA wobble adenosine to inosine editing
IY73_RS03500	COG0287	Prephenate dehydrogenase
IY73_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
IY73_RS03550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IY73_RS03560	COG0803	Belongs to the bacterial solute-binding protein 9 family
IY73_RS03575	COG0785	Cytochrome C biogenesis protein
IY73_RS03585	COG0386	Belongs to the glutathione peroxidase family
IY73_RS03590	COG0110	maltose O-acetyltransferase activity
IY73_RS03665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IY73_RS03730	COG0604	alcohol dehydrogenase
IY73_RS03745	COG1216	Glycosyl transferase, family 2
IY73_RS03750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IY73_RS03770	COG1216	Glycosyl transferase, family 2
IY73_RS03815	COG0277	FAD linked oxidase domain protein
IY73_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
IY73_RS03840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IY73_RS03850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IY73_RS03855	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
IY73_RS03865	COG5479	isomerase activity
IY73_RS03865	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IY73_RS03875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IY73_RS03880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IY73_RS03880	COG3321	synthase
IY73_RS03880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IY73_RS03885	COG0318	PFAM AMP-dependent synthetase and ligase
IY73_RS03900	COG1216	Glycosyl transferase, family 2
IY73_RS03925	COG0561	phosphatase activity
IY73_RS03930	COG0204	Acyl-transferase
IY73_RS03935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IY73_RS03940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IY73_RS03945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IY73_RS03960	COG1131	(ABC) transporter
IY73_RS03970	COG1132	(ABC) transporter
IY73_RS04000	COG3433	isochorismatase activity
IY73_RS04000	COG2226	methyltransferase
IY73_RS04000	COG3433	isochorismatase activity
IY73_RS04000	COG2226	methyltransferase
IY73_RS04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IY73_RS04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IY73_RS04020	COG0406	alpha-ribazole phosphatase activity
IY73_RS04025	COG0077	Prephenate dehydratase
IY73_RS04035	COG1316	TRANSCRIPTIONal
IY73_RS04050	COG0469	pyruvate kinase activity
IY73_RS04055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IY73_RS04060	COG1937	Protein conserved in bacteria
IY73_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
IY73_RS04160	COG0328	RNA-DNA hybrid ribonuclease activity
IY73_RS04170	COG0778	Nitroreductase
IY73_RS04175	COG2116	formate transmembrane transporter activity
IY73_RS04185	COG2807	transmembrane transport
IY73_RS04200	COG0181	hydroxymethylbilane synthase activity
IY73_RS04210	COG2375	cellular response to nickel ion
IY73_RS04210	COG1132	(ABC) transporter
IY73_RS04225	COG2226	methyltransferase
IY73_RS04260	COG1678	Uncharacterized ACR, COG1678
IY73_RS04265	COG0617	tRNA 3'-terminal CCA addition
IY73_RS04295	COG3118	belongs to the thioredoxin family
IY73_RS04300	COG0860	N-Acetylmuramoyl-L-alanine amidase
IY73_RS04300	COG3409	Peptidoglycan-binding domain 1 protein
IY73_RS04315	COG1192	Involved in chromosome partitioning
IY73_RS04320	COG0357	Ribosomal RNA small subunit methyltransferase G
IY73_RS04325	COG1847	R3H domain protein
IY73_RS04330	COG0706	membrane insertase activity
IY73_RS04335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IY73_RS04345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IY73_RS04355	COG0592	DNA-directed DNA polymerase activity
IY73_RS04360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IY73_RS04365	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IY73_RS04370	COG0187	DNA topoisomerase II activity
IY73_RS04375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IY73_RS04390	COG1002	Type II restriction enzyme, methylase subunits
IY73_RS04405	COG0705	Rhomboid family
IY73_RS04415	COG1518	maintenance of DNA repeat elements
IY73_RS04465	COG3579	cysteine-type endopeptidase activity
IY73_RS04490	COG0515	serine threonine protein kinase
IY73_RS04490	COG2815	serine threonine protein kinase
IY73_RS04495	COG2815	serine threonine protein kinase
IY73_RS04495	COG0515	serine threonine protein kinase
IY73_RS04500	COG0515	serine threonine protein kinase
IY73_RS04505	COG0768	penicillin binding
IY73_RS04510	COG0772	Belongs to the SEDS family
IY73_RS04520	COG1716	ATPase activity
IY73_RS04525	COG1716	ATPase activity
IY73_RS04530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IY73_RS04540	COG1511	domain protein
IY73_RS04545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IY73_RS04585	COG0495	leucyl-tRNA aminoacylation
IY73_RS04595	COG1741	Belongs to the pirin family
IY73_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
IY73_RS04615	COG2267	carboxylic ester hydrolase activity
IY73_RS04630	COG1053	succinate dehydrogenase
IY73_RS04635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IY73_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IY73_RS04655	COG0601	transmembrane transport
IY73_RS04660	COG4166	transmembrane transport
IY73_RS04685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IY73_RS04695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IY73_RS04700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IY73_RS04710	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IY73_RS04725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IY73_RS04735	COG1090	epimerase
IY73_RS04770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IY73_RS04780	COG3001	Fructosamine kinase
IY73_RS04790	COG1335	isochorismatase
IY73_RS04795	COG0531	amino acid
IY73_RS04800	COG3842	ATPase activity
IY73_RS04825	COG0028	Belongs to the TPP enzyme family
IY73_RS04850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IY73_RS04865	COG0359	binds to the 23S rRNA
IY73_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
IY73_RS04880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IY73_RS04885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IY73_RS04915	COG0577	efflux transmembrane transporter activity
IY73_RS04920	COG1136	(ABC) transporter
IY73_RS04920	COG0577	efflux transmembrane transporter activity
IY73_RS04925	COG0564	pseudouridine synthase activity
IY73_RS04935	COG1376	ErfK ybiS ycfS ynhG family protein
IY73_RS04945	COG3590	peptidase
IY73_RS04970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IY73_RS05000	COG0500	methyltransferase
IY73_RS05005	COG0438	transferase activity, transferring glycosyl groups
IY73_RS05025	COG4981	capsule polysaccharide biosynthetic process
IY73_RS05055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IY73_RS05055	COG0512	Glutamine amidotransferase of anthranilate synthase
IY73_RS05060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IY73_RS05070	COG0159	tryptophan synthase activity
IY73_RS05095	COG5650	phosphatidylinositol metabolic process
IY73_RS05105	COG0717	Belongs to the dCTP deaminase family
IY73_RS05120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IY73_RS05135	COG0247	lactate metabolic process
IY73_RS05135	COG2181	nitrate reductase activity
IY73_RS05165	COG0484	heat shock protein binding
IY73_RS05170	COG0789	Transcriptional regulator
IY73_RS05180	COG0542	response to heat
IY73_RS05200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IY73_RS05205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IY73_RS05220	COG0191	fructose-bisphosphate aldolase activity
IY73_RS05230	COG4129	membrane
IY73_RS05235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IY73_RS05240	COG1115	amino acid carrier protein
IY73_RS05245	COG1115	amino acid carrier protein
IY73_RS05250	COG1501	Belongs to the glycosyl hydrolase 31 family
IY73_RS05255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IY73_RS05280	COG1492	cobalamin metabolic process
IY73_RS05285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IY73_RS05300	COG5640	endopeptidase activity
IY73_RS05305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IY73_RS05310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IY73_RS05315	COG0697	spore germination
IY73_RS05355	COG0651	ATP synthesis coupled electron transport
IY73_RS05360	COG1006	Multisubunit Na H antiporter MnhC subunit
IY73_RS05365	COG2111	Na H antiporter
IY73_RS05365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IY73_RS05385	COG1408	metallophosphoesterase
IY73_RS05420	COG0596	Alpha beta hydrolase
IY73_RS05465	COG1205	dead DEAH box helicase
IY73_RS05465	COG1111	helicase
IY73_RS05485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IY73_RS05485	COG1754	DNA topoisomerase type I activity
IY73_RS05495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IY73_RS05510	COG2837	iron assimilation
IY73_RS05525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IY73_RS05545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IY73_RS05550	COG2027	D-alanyl-D-alanine carboxypeptidase
IY73_RS05555	COG2027	D-alanyl-D-alanine carboxypeptidase
IY73_RS05560	COG0037	tRNA processing
IY73_RS05570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IY73_RS05575	COG0302	gtp cyclohydrolase
IY73_RS05585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IY73_RS05590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IY73_RS05615	COG2271	Major facilitator Superfamily
IY73_RS05620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IY73_RS05645	COG1194	a g-specific adenine glycosylase
IY73_RS05660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IY73_RS05665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IY73_RS05680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IY73_RS05685	COG1121	(ABC) transporter
IY73_RS05695	COG1609	Transcriptional regulator
IY73_RS05700	COG0477	Major facilitator Superfamily
IY73_RS05715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IY73_RS05735	COG2723	6-phospho-beta-galactosidase activity
IY73_RS05740	COG0745	RESPONSE REGULATOR receiver
IY73_RS05745	COG2205	protein histidine kinase activity
IY73_RS05755	COG0151	Belongs to the GarS family
IY73_RS05760	COG0584	glycerophosphoryl diester phosphodiesterase
IY73_RS05770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IY73_RS05775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IY73_RS05785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IY73_RS05795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IY73_RS05810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IY73_RS05820	COG0354	folic acid binding
IY73_RS05825	COG1271	oxidase subunit
IY73_RS05830	COG1294	oxidase, subunit
IY73_RS05835	COG4988	ABC transporter
IY73_RS05840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IY73_RS05845	COG4044	May play a role in the intracellular transport of hydrophobic ligands
IY73_RS05860	COG0745	RESPONSE REGULATOR receiver
IY73_RS05865	COG0456	acetyltransferase
IY73_RS05880	COG0581	inorganic phosphate transmembrane transporter activity
IY73_RS05885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IY73_RS05900	COG0427	acetyl-CoA hydrolase
IY73_RS05905	COG3830	Belongs to the UPF0237 family
IY73_RS05910	COG2848	UPF0210 protein
IY73_RS05915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IY73_RS05920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IY73_RS05930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IY73_RS05935	COG2873	o-acetylhomoserine
IY73_RS05940	COG2873	o-acetylhomoserine
IY73_RS05945	COG0477	Major facilitator Superfamily
IY73_RS05955	COG2814	Major facilitator Superfamily
IY73_RS05965	COG0180	Tryptophanyl-tRNA synthetase
IY73_RS05970	COG1295	ribonuclease BN
IY73_RS05985	COG3883	PFAM NLP P60 protein
IY73_RS05985	COG0791	NLP P60 protein
IY73_RS05995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IY73_RS06010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IY73_RS06015	COG4770	biotin carboxylase activity
IY73_RS06025	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IY73_RS06035	COG0424	maF-like protein
IY73_RS06040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IY73_RS06085	COG1316	TRANSCRIPTIONal
IY73_RS06095	COG1091	dTDP-4-dehydrorhamnose reductase activity
IY73_RS06105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IY73_RS06135	COG1482	cell wall glycoprotein biosynthetic process
IY73_RS06150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IY73_RS06155	COG0745	RESPONSE REGULATOR receiver
IY73_RS06160	COG5002	protein histidine kinase activity
IY73_RS06165	COG5401	PFAM Sporulation and spore germination
IY73_RS06175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IY73_RS06200	COG1162	GTPase activity
IY73_RS06205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IY73_RS06210	COG1132	(ABC) transporter
IY73_RS06215	COG1132	(ABC) transporter
IY73_RS06220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IY73_RS06245	COG0513	Belongs to the DEAD box helicase family
IY73_RS06280	COG0210	DNA helicase
IY73_RS06285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IY73_RS06290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IY73_RS06315	COG3480	Lon protease (S16) C-terminal proteolytic domain
IY73_RS06320	COG1615	UPF0182 protein
IY73_RS06335	COG1115	amino acid carrier protein
IY73_RS06340	COG4868	Belongs to the UPF0371 family
IY73_RS06355	COG4475	Protein of unknown function (DUF436)
IY73_RS06360	COG0351	phosphomethylpyrimidine kinase
IY73_RS06385	COG0483	inositol monophosphate 1-phosphatase activity
IY73_RS06400	COG0156	8-amino-7-oxononanoate synthase activity
IY73_RS06415	COG3345	alpha-galactosidase
IY73_RS06420	COG3345	alpha-galactosidase
IY73_RS06425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IY73_RS06430	COG0668	transmembrane transport
IY73_RS06440	COG2884	Cell division ATP-binding protein ftsE
IY73_RS06445	COG2177	Part of the ABC transporter FtsEX involved in
IY73_RS06450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IY73_RS06495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IY73_RS06500	COG2814	Major facilitator Superfamily
IY73_RS06515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IY73_RS06520	COG0560	Phosphoserine phosphatase
IY73_RS06520	COG3830	Belongs to the UPF0237 family
IY73_RS06525	COG4716	Myosin-crossreactive antigen
IY73_RS06540	COG1129	ABC transporter
IY73_RS06560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IY73_RS06575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IY73_RS06600	COG1376	ErfK ybiS ycfS ynhG family protein
IY73_RS06625	COG3237	CsbD-like
IY73_RS06635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IY73_RS06640	COG0300	oxidoreductase activity
IY73_RS06655	COG4974	Belongs to the 'phage' integrase family
IY73_RS06695	COG3959	Transketolase, thiamine diphosphate binding domain
IY73_RS06700	COG3958	Transketolase
IY73_RS06715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IY73_RS06730	COG0006	proline dipeptidase activity
IY73_RS06755	COG0544	peptidyl-prolyl cis-trans isomerase activity
IY73_RS06765	COG0740	serine-type endopeptidase activity
IY73_RS06770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IY73_RS06775	COG0039	L-malate dehydrogenase activity
IY73_RS06780	COG0525	valine-tRNA ligase activity
IY73_RS06785	COG0285	dihydrofolate synthase activity
IY73_RS06790	COG0105	UTP biosynthetic process
IY73_RS06795	COG1530	ribonuclease E activity
IY73_RS06805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IY73_RS06810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IY73_RS06840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IY73_RS06845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IY73_RS06855	COG0406	alpha-ribazole phosphatase activity
IY73_RS06860	COG2755	lipolytic protein G-D-S-L family
IY73_RS06865	COG1596	polysaccharide export
IY73_RS06865	COG1555	photosystem II stabilization
IY73_RS06890	COG0481	GTPase activity
IY73_RS06900	COG0339	signal peptide processing
IY73_RS06915	COG1420	regulation of RNA biosynthetic process
IY73_RS06920	COG0484	heat shock protein binding
IY73_RS06935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IY73_RS06950	COG1381	Involved in DNA repair and RecF pathway recombination
IY73_RS06955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IY73_RS06965	COG0423	glycine-tRNA ligase activity
IY73_RS06970	COG2860	membrane
IY73_RS06995	COG0488	(ABC) transporter
IY73_RS07055	COG1007	ATP synthesis coupled electron transport
IY73_RS07065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IY73_RS07070	COG0713	ATP synthesis coupled electron transport
IY73_RS07080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IY73_RS07085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IY73_RS07090	COG1034	ATP synthesis coupled electron transport
IY73_RS07095	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IY73_RS07105	COG0649	NAD binding
IY73_RS07110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IY73_RS07115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IY73_RS07170	COG0686	Belongs to the AlaDH PNT family
IY73_RS07190	COG0174	glutamine synthetase
IY73_RS07195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IY73_RS07210	COG4558	Periplasmic binding protein
IY73_RS07215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IY73_RS07220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IY73_RS07225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IY73_RS07260	COG0174	glutamine synthetase
IY73_RS07275	COG0321	lipoyl(octanoyl) transferase activity
IY73_RS07280	COG0508	dehydrogenase complex catalyzes the overall conversion of
IY73_RS07285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IY73_RS07290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IY73_RS07295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IY73_RS07300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IY73_RS07315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IY73_RS07340	COG0438	transferase activity, transferring glycosyl groups
IY73_RS07350	COG1940	carbohydrate kinase activity
IY73_RS07360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IY73_RS07380	COG0142	geranyltranstransferase activity
IY73_RS07390	COG0456	acetyltransferase
IY73_RS07405	COG2001	Belongs to the MraZ family
IY73_RS07410	COG0275	rRNA processing
IY73_RS07420	COG0768	penicillin binding
IY73_RS07425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IY73_RS07440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IY73_RS07450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IY73_RS07455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IY73_RS07460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IY73_RS07465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IY73_RS07470	COG1496	oxidoreductase activity
IY73_RS07480	COG1799	cell septum assembly
IY73_RS07490	COG3599	regulation of cell shape
IY73_RS07500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IY73_RS07515	COG0252	asparaginase activity
IY73_RS07525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IY73_RS07540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IY73_RS07545	COG1739	Uncharacterized protein family UPF0029
IY73_RS07560	COG2755	lipolytic protein G-D-S-L family
IY73_RS07560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IY73_RS07565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IY73_RS07570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IY73_RS07580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IY73_RS07585	COG1051	belongs to the nudix hydrolase family
IY73_RS07585	COG1056	cytidyltransferase-related domain
IY73_RS07590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IY73_RS07605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IY73_RS07610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IY73_RS07615	COG0131	Imidazoleglycerol-phosphate dehydratase
IY73_RS07625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IY73_RS07630	COG0107	imidazoleglycerol-phosphate synthase activity
IY73_RS07635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IY73_RS07640	COG0134	indole-3-glycerol-phosphate synthase activity
IY73_RS07645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IY73_RS07650	COG0469	pyruvate kinase activity
IY73_RS07655	COG0058	SHG alpha-glucan phosphorylase activity
IY73_RS07690	COG0539	negative regulation of cytoplasmic translation
IY73_RS07695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IY73_RS07695	COG0237	dephospho-CoA kinase activity
IY73_RS07705	COG1609	Transcriptional regulator
IY73_RS07735	COG3973	AAA domain
IY73_RS07750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IY73_RS07765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IY73_RS07770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IY73_RS07770	COG0072	phenylalanine-tRNA ligase activity
IY73_RS07775	COG0351	phosphomethylpyrimidine kinase
IY73_RS07775	COG0352	thiamine-phosphate diphosphorylase activity
IY73_RS07775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IY73_RS07780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IY73_RS07785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IY73_RS07790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IY73_RS07795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IY73_RS07805	COG1438	arginine binding
IY73_RS07810	COG0137	argininosuccinate synthase activity
IY73_RS07815	COG0165	Argininosuccinate lyase
IY73_RS07820	COG2835	tetraacyldisaccharide 4'-kinase activity
IY73_RS07825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IY73_RS07850	COG0647	UMP catabolic process
IY73_RS07865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IY73_RS07885	COG0504	CTP synthase activity
IY73_RS07890	COG0494	nUDIX hydrolase
IY73_RS07910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IY73_RS07920	COG1160	GTP binding
IY73_RS07935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family