locus-tag	class	description
APT61_RS00010	COG3312	ion transport
APT61_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
APT61_RS00020	COG0445	tRNA wobble uridine modification
APT61_RS00025	COG0716	FMN binding
APT61_RS00030	COG1522	sequence-specific DNA binding
APT61_RS00035	COG2502	aspartate--ammonia ligase
APT61_RS00040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APT61_RS00050	COG3158	transport of potassium into the cell
APT61_RS00055	COG1869	D-ribose catabolic process
APT61_RS00065	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS00070	COG1879	ABC-type sugar transport system periplasmic component
APT61_RS00075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT61_RS00080	COG1609	Transcriptional regulator
APT61_RS00085	COG0477	Major facilitator Superfamily
APT61_RS00090	COG2186	Transcriptional regulator
APT61_RS00120	COG1763	Mo-molybdopterin cofactor biosynthetic process
APT61_RS00125	COG0746	molybdenum cofactor guanylyltransferase activity
APT61_RS00130	COG3084	Protein conserved in bacteria
APT61_RS00135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APT61_RS00145	COG0204	Acyl-transferase
APT61_RS00160	COG3078	GTPase activator activity
APT61_RS00165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT61_RS00175	COG3852	Histidine kinase
APT61_RS00190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APT61_RS00205	COG1501	Belongs to the glycosyl hydrolase 31 family
APT61_RS00215	COG3684	Belongs to the aldolase LacD family
APT61_RS00225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT61_RS00230	COG1349	DNA-binding transcription factor activity
APT61_RS00235	COG1011	Hydrolase
APT61_RS00240	COG1295	ribonuclease BN
APT61_RS00245	COG1490	D-aminoacyl-tRNA deacylase activity
APT61_RS00250	COG0456	acetyltransferase
APT61_RS00265	COG3210	domain, Protein
APT61_RS00285	COG3210	domain, Protein
APT61_RS00315	COG3210	domain, Protein
APT61_RS00325	COG2831	hemolysin activation secretion protein
APT61_RS00335	COG2864	formate dehydrogenase
APT61_RS00340	COG0437	4 iron, 4 sulfur cluster binding
APT61_RS00345	COG0243	molybdopterin cofactor binding
APT61_RS00345	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS00350	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS00350	COG0243	molybdopterin cofactor binding
APT61_RS00370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APT61_RS00390	COG2211	Major facilitator Superfamily
APT61_RS00400	COG1454	alcohol dehydrogenase
APT61_RS00410	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS00415	COG1129	ABC transporter
APT61_RS00430	COG4806	L-rhamnose isomerase
APT61_RS00435	COG1070	Carbohydrate kinase
APT61_RS00440	COG4977	sequence-specific DNA binding
APT61_RS00445	COG1917	Cupin 2, conserved barrel domain protein
APT61_RS00445	COG4977	sequence-specific DNA binding
APT61_RS00455	COG2258	MOSC domain
APT61_RS00460	COG2205	protein histidine kinase activity
APT61_RS00465	COG0745	RESPONSE REGULATOR receiver
APT61_RS00470	COG3678	ATP-independent chaperone mediated protein folding
APT61_RS00480	COG0205	6-phosphofructokinase activity
APT61_RS00490	COG2134	cdp-diacylglycerol pyrophosphatase
APT61_RS00500	COG0149	triose-phosphate isomerase activity
APT61_RS00510	COG3152	Membrane
APT61_RS00520	COG1494	fructose-1,6-bisphosphatase
APT61_RS00525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT61_RS00530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APT61_RS00535	COG3074	FtsZ-dependent cytokinesis
APT61_RS00555	COG1575	Belongs to the MenA family. Type 1 subfamily
APT61_RS00560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APT61_RS00570	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT61_RS00575	COG1609	Transcriptional regulator
APT61_RS00580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APT61_RS00585	COG0254	rRNA binding
APT61_RS00600	COG0626	cystathionine gamma-synthase activity
APT61_RS00605	COG0460	homoserine dehydrogenase
APT61_RS00605	COG0527	aspartate kinase activity
APT61_RS00620	COG0371	Dehydrogenase
APT61_RS00630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS00630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS00630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT61_RS00635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS00640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS00645	COG1882	Formate acetyltransferase
APT61_RS00650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT61_RS00655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS00660	COG2207	Transcriptional regulator
APT61_RS00665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APT61_RS00670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT61_RS00675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT61_RS00680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT61_RS00685	COG0165	Argininosuccinate lyase
APT61_RS00690	COG0583	DNA-binding transcription factor activity
APT61_RS00695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT61_RS00710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT61_RS00715	COG4206	TonB-dependent receptor
APT61_RS00770	COG3085	chromosome segregation
APT61_RS00785	COG3978	acetolactate synthase activity
APT61_RS00790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT61_RS00800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT61_RS00805	COG0583	DNA-binding transcription factor activity
APT61_RS00810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APT61_RS00820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT61_RS00830	COG0248	Ppx GppA phosphatase
APT61_RS00840	COG3118	belongs to the thioredoxin family
APT61_RS00845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APT61_RS00850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT61_RS00865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APT61_RS00870	COG0456	acetyltransferase
APT61_RS00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APT61_RS00880	COG2244	polysaccharide biosynthetic process
APT61_RS00895	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APT61_RS00935	COG3071	HemY protein
APT61_RS00940	COG2959	enzyme of heme biosynthesis
APT61_RS00950	COG0181	hydroxymethylbilane synthase activity
APT61_RS00960	COG1965	Belongs to the frataxin family
APT61_RS00985	COG1011	Hydrolase
APT61_RS00990	COG0210	DNA helicase
APT61_RS01010	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APT61_RS01020	COG1280	lysine exporter protein (LysE YggA)
APT61_RS01025	COG1280	lysine exporter protein (LysE YggA)
APT61_RS01030	COG2267	carboxylic ester hydrolase activity
APT61_RS01035	COG0561	phosphatase activity
APT61_RS01040	COG0697	spore germination
APT61_RS01045	COG0583	DNA-binding transcription factor activity
APT61_RS01050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT61_RS01055	COG0412	Dienelactone hydrolase
APT61_RS01065	COG1322	Protein conserved in bacteria
APT61_RS01070	COG2226	methyltransferase
APT61_RS01075	COG3165	ubiquinone biosynthetic process from chorismate
APT61_RS01080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT61_RS01095	COG0805	protein transport
APT61_RS01100	COG0084	hydrolase, TatD family'
APT61_RS01110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APT61_RS01120	COG0183	Belongs to the thiolase family
APT61_RS01125	COG1024	Enoyl-CoA hydratase
APT61_RS01125	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT61_RS01135	COG1739	Uncharacterized protein family UPF0029
APT61_RS01145	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APT61_RS01180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APT61_RS01185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APT61_RS01185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APT61_RS01190	COG2200	EAL domain
APT61_RS01190	COG2199	diguanylate cyclase activity
APT61_RS01195	COG1301	dicarboxylic acid transport
APT61_RS01200	COG0612	Peptidase, M16
APT61_RS01210	COG2200	EAL domain
APT61_RS01215	COG2982	Protein involved in outer membrane biogenesis
APT61_RS01220	COG0477	Major facilitator Superfamily
APT61_RS01225	COG1295	ribonuclease BN
APT61_RS01230	COG0583	DNA-binding transcription factor activity
APT61_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS01240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT61_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT61_RS01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APT61_RS01280	COG0339	signal peptide processing
APT61_RS01285	COG0742	ribosomal rna small subunit methyltransferase
APT61_RS01290	COG0589	response to stress
APT61_RS01305	COG0306	phosphate transporter
APT61_RS01310	COG2081	HI0933 family
APT61_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS01330	COG2091	lysine biosynthetic process via aminoadipic acid
APT61_RS01335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT61_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS01375	COG0463	Glycosyl transferase, family 2
APT61_RS01395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT61_RS01420	COG0628	permease
APT61_RS01435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APT61_RS01440	COG0425	Belongs to the sulfur carrier protein TusA family
APT61_RS01445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT61_RS01465	COG3714	YhhN family
APT61_RS01475	COG3776	membrane
APT61_RS01480	COG0742	ribosomal rna small subunit methyltransferase
APT61_RS01485	COG0552	protein localization to endoplasmic reticulum
APT61_RS01490	COG2884	Cell division ATP-binding protein ftsE
APT61_RS01495	COG2177	Part of the ABC transporter FtsEX involved in
APT61_RS01500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT61_RS01505	COG0683	leucine binding
APT61_RS01515	COG1704	LemA family
APT61_RS01525	COG0683	leucine binding
APT61_RS01535	COG4177	L-phenylalanine transmembrane transporter activity
APT61_RS01570	COG0584	glycerophosphoryl diester phosphodiesterase
APT61_RS01580	COG0405	Gamma-glutamyltransferase
APT61_RS01585	COG1247	-acetyltransferase
APT61_RS01590	COG0673	inositol 2-dehydrogenase activity
APT61_RS01595	COG1741	Belongs to the pirin family
APT61_RS01600	COG1609	Transcriptional regulator
APT61_RS01605	COG3265	gluconokinase activity
APT61_RS01610	COG2610	gluconate transmembrane transporter activity
APT61_RS01615	COG2095	MarC family integral membrane protein
APT61_RS01620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT61_RS01625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT61_RS01630	COG1523	belongs to the glycosyl hydrolase 13 family
APT61_RS01635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT61_RS01640	COG0297	glycogen (starch) synthase activity
APT61_RS01645	COG0058	SHG alpha-glucan phosphorylase activity
APT61_RS01650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APT61_RS01655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT61_RS01660	COG0705	Rhomboid family
APT61_RS01665	COG1349	DNA-binding transcription factor activity
APT61_RS01670	COG2909	trisaccharide binding
APT61_RS01675	COG0058	SHG alpha-glucan phosphorylase activity
APT61_RS01680	COG1640	4-alpha-glucanotransferase
APT61_RS01685	COG2610	gluconate transmembrane transporter activity
APT61_RS01695	COG1040	competence protein
APT61_RS01720	COG1918	ferrous iron import across plasma membrane
APT61_RS01725	COG2183	response to ionizing radiation
APT61_RS01730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT61_RS01745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APT61_RS01750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT61_RS01755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APT61_RS01760	COG1011	Hydrolase
APT61_RS01770	COG0494	nUDIX hydrolase
APT61_RS01775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APT61_RS01780	COG4972	Pilus assembly protein
APT61_RS01800	COG4796	Type ii and iii secretion system protein
APT61_RS01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT61_RS01810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APT61_RS01815	COG3266	domain, Protein
APT61_RS01820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APT61_RS01825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT61_RS01835	COG0180	Tryptophanyl-tRNA synthetase
APT61_RS01840	COG1648	precorrin-2 dehydrogenase activity
APT61_RS01840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APT61_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT61_RS01860	COG0402	S-adenosylhomocysteine deaminase activity
APT61_RS01865	COG0738	Major facilitator superfamily
APT61_RS01880	COG0512	Glutamine amidotransferase of anthranilate synthase
APT61_RS01890	COG1289	transmembrane transporter activity
APT61_RS01900	COG1765	OsmC-like protein
APT61_RS01905	COG3954	Phosphoribulokinase
APT61_RS01910	COG3089	Belongs to the UPF0270 family
APT61_RS01915	COG0429	hydrolase of the alpha beta-hydrolase fold
APT61_RS01945	COG0679	Auxin Efflux Carrier
APT61_RS01955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT61_RS01965	COG0488	(ABC) transporter
APT61_RS01975	COG0475	glutathione-regulated potassium exporter activity
APT61_RS01975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT61_RS01980	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
APT61_RS01985	COG1047	Peptidyl-prolyl cis-trans
APT61_RS01990	COG2900	Belongs to the SlyX family
APT61_RS01995	COG0545	Peptidyl-prolyl cis-trans isomerase
APT61_RS02000	COG2964	Protein conserved in bacteria
APT61_RS02005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APT61_RS02010	COG2923	Belongs to the DsrF TusC family
APT61_RS02015	COG2168	tRNA wobble position uridine thiolation
APT61_RS02055	COG0051	transcription antitermination factor activity, RNA binding
APT61_RS02065	COG0088	Forms part of the polypeptide exit tunnel
APT61_RS02080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APT61_RS02095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT61_RS02100	COG0255	Belongs to the universal ribosomal protein uL29 family
APT61_RS02110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT61_RS02120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT61_RS02130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT61_RS02135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT61_RS02140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT61_RS02145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT61_RS02150	COG1841	ribosomal large subunit assembly
APT61_RS02155	COG0200	Binds to the 23S rRNA
APT61_RS02160	COG0201	protein transport
APT61_RS02170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT61_RS02180	COG0202	RNA polymerase activity
APT61_RS02195	COG0789	Transcriptional regulator
APT61_RS02210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT61_RS02210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT61_RS02225	COG0758	DNA mediated transformation
APT61_RS02230	COG2922	Belongs to the Smg family
APT61_RS02240	COG0009	L-threonylcarbamoyladenylate synthase
APT61_RS02245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT61_RS02255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APT61_RS02295	COG1126	abc transporter atp-binding protein
APT61_RS02300	COG0765	amino acid transport
APT61_RS02305	COG4597	amino acid ABC transporter
APT61_RS02310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS02320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT61_RS02325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS02330	COG1309	transcriptional regulator
APT61_RS02360	COG4145	pantothenate transmembrane transporter activity
APT61_RS02365	COG3924	membrane
APT61_RS02370	COG0439	Biotin carboxylase
APT61_RS02375	COG0511	ligase activity, forming carbon-carbon bonds
APT61_RS02380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APT61_RS02385	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APT61_RS02395	COG0604	alcohol dehydrogenase
APT61_RS02400	COG2200	EAL domain
APT61_RS02400	COG2199	diguanylate cyclase activity
APT61_RS02405	COG1077	Cell shape determining protein MreB Mrl
APT61_RS02410	COG1792	Involved in formation and maintenance of cell shape
APT61_RS02415	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APT61_RS02430	COG3164	Protein of unknown function
APT61_RS02435	COG0312	modulator of DNA gyrase
APT61_RS02440	COG0583	DNA-binding transcription factor activity
APT61_RS02445	COG1566	PFAM secretion protein HlyD family protein
APT61_RS02450	COG1289	transmembrane transporter activity
APT61_RS02455	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS02460	COG2732	(Barnase) inhibitor
APT61_RS02475	COG1438	arginine binding
APT61_RS02485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT61_RS02490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT61_RS02495	COG3105	Protein conserved in bacteria
APT61_RS02500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APT61_RS02515	COG0625	glutathione transferase activity
APT61_RS02520	COG2969	positive regulation of protein catabolic process
APT61_RS02525	COG3121	Chaperone
APT61_RS02530	COG3188	usher protein
APT61_RS02540	COG0493	'glutamate synthase
APT61_RS02545	COG0067	glutamate synthase
APT61_RS02545	COG0069	glutamate synthase activity
APT61_RS02545	COG0070	glutamate synthase
APT61_RS02555	COG1242	4 iron, 4 sulfur cluster binding
APT61_RS02560	COG0433	COG0433 Predicted ATPase
APT61_RS02570	COG1064	alcohol dehydrogenase
APT61_RS02585	COG2927	DNA polymerase III (CHI subunit)
APT61_RS02590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT61_RS02595	COG0795	lipopolysaccharide-transporting ATPase activity
APT61_RS02600	COG0795	lipopolysaccharide-transporting ATPase activity
APT61_RS02605	COG2198	Histidine kinase
APT61_RS02605	COG0784	Response regulator, receiver
APT61_RS02605	COG5002	protein histidine kinase activity
APT61_RS02610	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APT61_RS02615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT61_RS02620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS02640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APT61_RS02645	COG1137	ATPase activity
APT61_RS02650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APT61_RS02655	COG3117	lipopolysaccharide transmembrane transporter activity
APT61_RS02660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APT61_RS02665	COG0517	IMP dehydrogenase activity
APT61_RS02665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APT61_RS02670	COG0530	calcium, potassium:sodium antiporter activity
APT61_RS02675	COG1127	ABC transporter
APT61_RS02680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT61_RS02685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APT61_RS02690	COG2854	intermembrane phospholipid transfer
APT61_RS02695	COG3113	response to antibiotic
APT61_RS02700	COG5007	Belongs to the BolA IbaG family
APT61_RS02705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT61_RS02710	COG3423	Transcriptional regulator
APT61_RS02715	COG0142	geranyltranstransferase activity
APT61_RS02720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APT61_RS02725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APT61_RS02730	COG0697	spore germination
APT61_RS02735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT61_RS02740	COG0642	Histidine kinase
APT61_RS02745	COG0745	RESPONSE REGULATOR receiver
APT61_RS02750	COG2027	D-alanyl-D-alanine carboxypeptidase
APT61_RS02755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT61_RS02760	COG1534	Rna-binding protein
APT61_RS02765	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APT61_RS02775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APT61_RS02780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT61_RS02785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT61_RS02795	COG0137	argininosuccinate synthase activity
APT61_RS02805	COG0779	Required for maturation of 30S ribosomal subunits
APT61_RS02810	COG0195	Participates in both transcription termination and antitermination
APT61_RS02815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APT61_RS02835	COG1185	polyribonucleotide nucleotidyltransferase activity
APT61_RS02845	COG0513	Belongs to the DEAD box helicase family
APT61_RS02850	COG0814	amino acid
APT61_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS02860	COG0826	peptidase U32
APT61_RS02865	COG0826	peptidase U32
APT61_RS02870	COG3154	lipid carrier protein
APT61_RS02875	COG3153	acetyltransferase
APT61_RS02880	COG2827	Endonuclease containing a URI domain
APT61_RS02885	COG3787	Belongs to the UPF0306 family
APT61_RS02890	COG0693	protein deglycase activity
APT61_RS02895	COG0702	epimerase
APT61_RS02900	COG2823	Periplasmic or secreted lipoprotein
APT61_RS02905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APT61_RS02910	COG0792	nuclease activity
APT61_RS02915	COG3107	peptidoglycan biosynthetic process
APT61_RS02920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APT61_RS02925	COG2721	sulfolactate sulfo-lyase activity
APT61_RS02930	COG2271	Major facilitator Superfamily
APT61_RS02935	COG3836	Belongs to the HpcH HpaI aldolase family
APT61_RS02940	COG2084	Dehydrogenase
APT61_RS02945	COG1929	Belongs to the glycerate kinase type-1 family
APT61_RS02965	COG0583	DNA-binding transcription factor activity
APT61_RS02975	COG0814	amino acid
APT61_RS02980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APT61_RS02985	COG1882	Formate acetyltransferase
APT61_RS02990	COG0814	amino acid
APT61_RS03000	COG1741	Belongs to the pirin family
APT61_RS03005	COG0583	DNA-binding transcription factor activity
APT61_RS03010	COG3152	Membrane
APT61_RS03015	COG0435	Glutathione S-transferase
APT61_RS03020	COG2259	Doxx family
APT61_RS03030	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
APT61_RS03035	COG4575	ribosome binding
APT61_RS03040	COG1422	Protein of unknown function (DUF1090)
APT61_RS03050	COG0586	Pfam SNARE associated Golgi protein
APT61_RS03055	COG2186	Transcriptional regulator
APT61_RS03060	COG2271	Major facilitator Superfamily
APT61_RS03070	COG2721	sulfolactate sulfo-lyase activity
APT61_RS03080	COG0861	Integral membrane protein TerC family
APT61_RS03085	COG0673	inositol 2-dehydrogenase activity
APT61_RS03090	COG1451	nucleotide metabolic process
APT61_RS03100	COG0446	pyridine nucleotide-disulphide oxidoreductase
APT61_RS03100	COG1902	pentaerythritol trinitrate reductase activity
APT61_RS03105	COG1070	Carbohydrate kinase
APT61_RS03110	COG2390	Transcriptional regulator
APT61_RS03115	COG1129	ABC transporter
APT61_RS03120	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS03125	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS03135	COG1830	Aldolase
APT61_RS03140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APT61_RS03145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT61_RS03150	COG0840	transmembrane signaling receptor activity
APT61_RS03155	COG0840	transmembrane signaling receptor activity
APT61_RS03160	COG1695	Transcriptional regulator
APT61_RS03165	COG2375	cellular response to nickel ion
APT61_RS03200	COG0457	Tetratricopeptide repeat
APT61_RS03210	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
APT61_RS03225	COG0582	viral genome integration into host DNA
APT61_RS03295	COG4695	Portal protein
APT61_RS03385	COG5301	cellulose 1,4-beta-cellobiosidase activity
APT61_RS03435	COG3663	DNA glycosylase
APT61_RS03445	COG0358	DNA primase activity
APT61_RS03450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT61_RS03465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APT61_RS03470	COG0830	nickel cation binding
APT61_RS03480	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APT61_RS03485	COG0804	urea catabolic process
APT61_RS03490	COG0832	Belongs to the urease beta subunit family
APT61_RS03495	COG0831	urea catabolic process
APT61_RS03500	COG0829	nickel cation binding
APT61_RS03505	COG0477	Major facilitator Superfamily
APT61_RS03515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APT61_RS03520	COG1968	undecaprenyl-diphosphatase activity
APT61_RS03525	COG0617	tRNA 3'-terminal CCA addition
APT61_RS03530	COG4991	sh3 domain protein
APT61_RS03535	COG3025	triphosphatase activity
APT61_RS03545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT61_RS03545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT61_RS03560	COG3539	Fimbrial protein
APT61_RS03565	COG3121	Chaperone
APT61_RS03570	COG3188	usher protein
APT61_RS03575	COG3539	Fimbrial protein
APT61_RS03585	COG3384	dioxygenase
APT61_RS03590	COG0754	glutathionylspermidine amidase activity
APT61_RS03600	COG1538	Outer membrane efflux protein
APT61_RS03605	COG0494	nUDIX hydrolase
APT61_RS03610	COG3151	Protein conserved in bacteria
APT61_RS03615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT61_RS03620	COG3150	esterase
APT61_RS03630	COG2207	Transcriptional regulator
APT61_RS03630	COG1917	Cupin 2, conserved barrel domain protein
APT61_RS03640	COG2211	Major facilitator Superfamily
APT61_RS03645	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APT61_RS03655	COG1652	LysM domain
APT61_RS03660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APT61_RS03665	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT61_RS03680	COG3111	PFAM Bacterial OB fold (BOF) protein
APT61_RS03690	COG0204	Acyl-transferase
APT61_RS03700	COG1032	radical SAM domain protein
APT61_RS03715	COG1979	alcohol dehydrogenase
APT61_RS03725	COG0586	Pfam SNARE associated Golgi protein
APT61_RS03730	COG0626	cystathionine gamma-synthase activity
APT61_RS03745	COG0848	biopolymer transport protein
APT61_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS03770	COG2862	Uncharacterized protein family, UPF0114
APT61_RS03775	COG0667	Aldo Keto reductase
APT61_RS03790	COG0840	transmembrane signaling receptor activity
APT61_RS03795	COG1349	DNA-binding transcription factor activity
APT61_RS03800	COG2199	diguanylate cyclase activity
APT61_RS03805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT61_RS03815	COG0625	glutathione transferase activity
APT61_RS03825	COG0601	transmembrane transport
APT61_RS03830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS03835	COG0444	Belongs to the ABC transporter superfamily
APT61_RS03840	COG4608	Belongs to the ABC transporter superfamily
APT61_RS03845	COG3647	Membrane
APT61_RS03850	COG4625	pathogenesis
APT61_RS03860	COG2188	Transcriptional regulator
APT61_RS03865	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS03870	COG1263	PTS System
APT61_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS03870	COG2190	(PTS) system
APT61_RS03905	COG1811	Na channel or pump
APT61_RS03910	COG1982	Orn Lys Arg decarboxylase major
APT61_RS03915	COG2211	Major facilitator Superfamily
APT61_RS03920	COG0741	lytic transglycosylase activity
APT61_RS03930	COG1194	a g-specific adenine glycosylase
APT61_RS03940	COG3171	Protein conserved in bacteria
APT61_RS03950	COG2852	Protein conserved in bacteria
APT61_RS03955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT61_RS03960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT61_RS03965	COG1872	DUF167
APT61_RS03970	COG0762	integral membrane protein
APT61_RS03975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT61_RS03980	COG2805	Type II/IV secretion system protein
APT61_RS03990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT61_RS04000	COG0189	ligase activity
APT61_RS04005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APT61_RS04010	COG2356	endonuclease I
APT61_RS04015	COG3091	SprT-like family
APT61_RS04020	COG2814	Major facilitator Superfamily
APT61_RS04035	COG0010	Belongs to the arginase family
APT61_RS04040	COG0501	Belongs to the peptidase M48B family
APT61_RS04045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT61_RS04050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT61_RS04055	COG0126	phosphoglycerate kinase activity
APT61_RS04060	COG0191	fructose-bisphosphate aldolase activity
APT61_RS04065	COG0668	transmembrane transport
APT61_RS04070	COG1279	arginine transmembrane transporter activity
APT61_RS04075	COG2968	Membrane
APT61_RS04080	COG0583	DNA-binding transcription factor activity
APT61_RS04085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APT61_RS04090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT61_RS04095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT61_RS04115	COG0006	proline dipeptidase activity
APT61_RS04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT61_RS04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT61_RS04145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT61_RS04145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT61_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS04155	COG2723	6-phospho-beta-galactosidase activity
APT61_RS04160	COG1737	Transcriptional regulator
APT61_RS04170	COG1272	protein, Hemolysin III
APT61_RS04175	COG0354	folic acid binding
APT61_RS04215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APT61_RS04220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APT61_RS04225	COG4942	peptidase
APT61_RS04240	COG3592	Divergent 4Fe-4S mono-cluster
APT61_RS04245	COG2388	GCN5-related N-acetyl-transferase
APT61_RS04250	COG0814	amino acid
APT61_RS04260	COG0583	DNA-binding transcription factor activity
APT61_RS04265	COG4297	protein containing double-stranded beta helix domain
APT61_RS04270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS04275	COG1473	amidohydrolase
APT61_RS04280	COG0183	Belongs to the thiolase family
APT61_RS04295	COG0823	Involved in the tonB-independent uptake of proteins
APT61_RS04300	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APT61_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS04310	COG2814	Major facilitator Superfamily
APT61_RS04315	COG0823	Involved in the tonB-independent uptake of proteins
APT61_RS04325	COG3842	ATPase activity
APT61_RS04330	COG0395	ABC-type sugar transport system, permease component
APT61_RS04335	COG1175	transmembrane transport
APT61_RS04345	COG1794	racemase activity, acting on amino acids and derivatives
APT61_RS04350	COG0583	DNA-binding transcription factor activity
APT61_RS04360	COG1609	Transcriptional regulator
APT61_RS04365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT61_RS04370	COG2723	6-phospho-beta-galactosidase activity
APT61_RS04375	COG2186	Transcriptional regulator
APT61_RS04385	COG1609	Transcriptional regulator
APT61_RS04390	COG0204	Acyl-transferase
APT61_RS04390	COG0318	PFAM AMP-dependent synthetase and ligase
APT61_RS04395	COG0477	Major facilitator Superfamily
APT61_RS04400	COG0667	Aldo Keto reductase
APT61_RS04410	COG3066	DNA modification
APT61_RS04415	COG0494	nUDIX hydrolase
APT61_RS04425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APT61_RS04430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APT61_RS04435	COG2165	general secretion pathway protein
APT61_RS04440	COG4795	General secretion pathway protein
APT61_RS04450	COG4967	type IV pilus modification protein PilV
APT61_RS04455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APT61_RS04465	COG1074	ATP-dependent DNA helicase activity
APT61_RS04470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APT61_RS04475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APT61_RS04475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT61_RS04480	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT61_RS04500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APT61_RS04505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APT61_RS04510	COG2166	iron-sulfur cluster assembly
APT61_RS04515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT61_RS04525	COG0583	DNA-binding transcription factor activity
APT61_RS04530	COG2363	Small membrane protein
APT61_RS04535	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
APT61_RS04545	COG1760	l-serine dehydratase
APT61_RS04550	COG0814	amino acid
APT61_RS04555	COG1611	Belongs to the LOG family
APT61_RS04575	COG3098	single-species biofilm formation
APT61_RS04580	COG0564	pseudouridine synthase activity
APT61_RS04585	COG0716	FMN binding
APT61_RS04590	COG2271	Major facilitator Superfamily
APT61_RS04595	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS04600	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS04605	COG1929	Belongs to the glycerate kinase type-1 family
APT61_RS04615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT61_RS04620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT61_RS04625	COG3956	TIGRFAM MazG family protein
APT61_RS04635	COG0148	phosphopyruvate hydratase activity
APT61_RS04645	COG0602	queuosine metabolic process
APT61_RS04650	COG0720	synthase
APT61_RS04655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APT61_RS04660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT61_RS04685	COG2234	aminopeptidase activity
APT61_RS04695	COG0175	sulfate reduction
APT61_RS04705	COG0529	Catalyzes the synthesis of activated sulfate
APT61_RS04715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APT61_RS04720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APT61_RS04730	COG0585	pseudouridine synthase activity
APT61_RS04745	COG1388	LysM domain
APT61_RS04745	COG4942	peptidase
APT61_RS04750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT61_RS04760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT61_RS04780	COG1120	ATPase activity
APT61_RS04785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS04795	COG2723	6-phospho-beta-galactosidase activity
APT61_RS04800	COG1263	PTS System
APT61_RS04800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS04805	COG1609	Transcriptional regulator
APT61_RS04815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS04815	COG2190	(PTS) system
APT61_RS04815	COG1263	PTS System
APT61_RS04820	COG0446	pyridine nucleotide-disulphide oxidoreductase
APT61_RS04830	COG3604	Transcriptional regulator
APT61_RS04840	COG1349	DNA-binding transcription factor activity
APT61_RS04845	COG2951	lytic endotransglycosylase activity
APT61_RS04850	COG1546	Belongs to the CinA family
APT61_RS04860	COG2137	regulation of response to DNA damage stimulus
APT61_RS04865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT61_RS04870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APT61_RS04900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT61_RS04905	COG1238	metal cluster binding
APT61_RS04910	COG2918	glutathione biosynthetic process
APT61_RS04915	COG1854	S-ribosylhomocysteine lyase activity
APT61_RS04920	COG2814	Major facilitator Superfamily
APT61_RS04925	COG1566	PFAM secretion protein HlyD family protein
APT61_RS04930	COG1846	Transcriptional regulator
APT61_RS04935	COG2814	Major facilitator Superfamily
APT61_RS04945	COG4176	ABC-type proline glycine betaine transport system permease component
APT61_RS04950	COG4175	Glycine betaine
APT61_RS04960	COG0309	Hydrogenase expression formation protein (HypE)
APT61_RS04965	COG0409	Hydrogenase expression formation protein
APT61_RS04970	COG0298	carbon dioxide binding
APT61_RS04975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APT61_RS04980	COG0375	protein maturation
APT61_RS04990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT61_RS04995	COG0651	ATP synthesis coupled electron transport
APT61_RS05000	COG0650	Formate hydrogenlyase subunit 4
APT61_RS05005	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
APT61_RS05005	COG3261	NADH dehydrogenase
APT61_RS05010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT61_RS05015	COG3260	NADH ubiquinone oxidoreductase 20
APT61_RS05025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APT61_RS05035	COG1196	nuclear chromosome segregation
APT61_RS05055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT61_RS05060	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS05065	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APT61_RS05070	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
APT61_RS05075	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS05080	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS05085	COG1278	Cold shock
APT61_RS05090	COG1280	lysine exporter protein (LysE YggA)
APT61_RS05105	COG1780	Probably involved in ribonucleotide reductase function
APT61_RS05110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT61_RS05115	COG4575	ribosome binding
APT61_RS05140	COG0583	DNA-binding transcription factor activity
APT61_RS05145	COG0666	response to abiotic stimulus
APT61_RS05150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APT61_RS05155	COG1304	FMN binding
APT61_RS05165	COG0549	Belongs to the carbamate kinase family
APT61_RS05170	COG0402	S-adenosylhomocysteine deaminase activity
APT61_RS05175	COG0583	DNA-binding transcription factor activity
APT61_RS05180	COG2271	Major facilitator Superfamily
APT61_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS05190	COG3959	Transketolase, thiamine diphosphate binding domain
APT61_RS05195	COG3958	Transketolase
APT61_RS05205	COG0583	DNA-binding transcription factor activity
APT61_RS05240	COG3210	domain, Protein
APT61_RS05300	COG3210	domain, Protein
APT61_RS05310	COG2831	hemolysin activation secretion protein
APT61_RS05315	COG3111	PFAM Bacterial OB fold (BOF) protein
APT61_RS05325	COG2323	membrane
APT61_RS05330	COG1546	Belongs to the CinA family
APT61_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS05340	COG1294	oxidase, subunit
APT61_RS05345	COG1271	oxidase subunit
APT61_RS05350	COG3546	catalase activity
APT61_RS05355	COG3685	Protein conserved in bacteria
APT61_RS05360	COG3685	Protein conserved in bacteria
APT61_RS05365	COG3729	General stress protein
APT61_RS05390	COG0583	DNA-binding transcription factor activity
APT61_RS05410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS05415	COG2274	protein secretion by the type I secretion system
APT61_RS05440	COG2186	Transcriptional regulator
APT61_RS05465	COG2731	YhcH YjgK YiaL family protein
APT61_RS05475	COG0583	DNA-binding transcription factor activity
APT61_RS05525	COG0582	viral genome integration into host DNA
APT61_RS05540	COG2867	negative regulation of translational initiation
APT61_RS05555	COG0497	DNA recombination
APT61_RS05560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APT61_RS05565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT61_RS05570	COG4536	flavin adenine dinucleotide binding
APT61_RS05575	COG4137	Cytochrome C assembly protein
APT61_RS05580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APT61_RS05590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APT61_RS05615	COG2885	chlorophyll binding
APT61_RS05620	COG2199	diguanylate cyclase activity
APT61_RS05630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT61_RS05635	COG0287	Prephenate dehydrogenase
APT61_RS05635	COG1605	Chorismate mutase
APT61_RS05645	COG1605	Chorismate mutase
APT61_RS05645	COG0077	Prephenate dehydratase
APT61_RS05650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APT61_RS05655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT61_RS05665	COG1496	oxidoreductase activity
APT61_RS05670	COG0542	response to heat
APT61_RS05705	COG0477	Major facilitator Superfamily
APT61_RS05710	COG5544	Lipoprotein
APT61_RS05715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT61_RS05725	COG3148	PFAM DTW domain containing protein
APT61_RS05730	COG3118	belongs to the thioredoxin family
APT61_RS05735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT61_RS05745	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APT61_RS05750	COG0513	Belongs to the DEAD box helicase family
APT61_RS05755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APT61_RS05760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APT61_RS05770	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APT61_RS05780	COG3086	response to oxidative stress
APT61_RS05785	COG0481	GTPase activity
APT61_RS05790	COG0681	Belongs to the peptidase S26 family
APT61_RS05795	COG0571	ribonuclease III activity
APT61_RS05800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT61_RS05805	COG1381	Involved in DNA repair and RecF pathway recombination
APT61_RS05810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APT61_RS05820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT61_RS05825	COG1737	Transcriptional regulator
APT61_RS05830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APT61_RS05835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS05835	COG1263	PTS System
APT61_RS05840	COG0560	Phosphoserine phosphatase
APT61_RS05845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
APT61_RS05850	COG0047	phosphoribosylformylglycinamidine synthase activity
APT61_RS05850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT61_RS05855	COG2205	protein histidine kinase activity
APT61_RS05860	COG3170	Tfp pilus assembly protein FimV
APT61_RS05865	COG2204	response regulator
APT61_RS05870	COG0347	Belongs to the P(II) protein family
APT61_RS05875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT61_RS05875	COG1017	nitric oxide dioxygenase activity
APT61_RS05885	COG2259	Doxx family
APT61_RS05890	COG2814	Major facilitator Superfamily
APT61_RS05895	COG3711	transcriptional antiterminator
APT61_RS05900	COG3683	transport system, periplasmic component
APT61_RS05905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APT61_RS05920	COG1959	2 iron, 2 sulfur cluster binding
APT61_RS05925	COG1104	cysteine desulfurase activity
APT61_RS05930	COG0822	iron-sulfur transferase activity
APT61_RS05935	COG0316	Belongs to the HesB IscA family
APT61_RS05945	COG0443	Heat shock 70 kDa protein
APT61_RS05950	COG0633	Ferredoxin
APT61_RS05955	COG2975	iron-sulfur cluster assembly
APT61_RS05960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT61_RS05975	COG2897	thiosulfate sulfurtransferase activity
APT61_RS05985	COG2190	(PTS) system
APT61_RS05985	COG1263	PTS System
APT61_RS05985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS05990	COG2373	Large extracellular alpha-helical protein
APT61_RS05995	COG4953	penicillin-binding protein 1C
APT61_RS06005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT61_RS06010	COG1426	Protein conserved in bacteria
APT61_RS06015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APT61_RS06020	COG0124	histidyl-tRNA synthetase
APT61_RS06025	COG2976	Protein conserved in bacteria
APT61_RS06035	COG1160	GTP binding
APT61_RS06050	COG1645	bacterial-type flagellum-dependent swarming motility
APT61_RS06070	COG1570	exodeoxyribonuclease VII activity
APT61_RS06075	COG0517	IMP dehydrogenase activity
APT61_RS06075	COG0516	GMP reductase activity
APT61_RS06080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT61_RS06080	COG0519	Catalyzes the synthesis of GMP from XMP
APT61_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS06110	COG0583	DNA-binding transcription factor activity
APT61_RS06120	COG2200	EAL domain
APT61_RS06135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APT61_RS06140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT61_RS06145	COG2723	6-phospho-beta-galactosidase activity
APT61_RS06150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT61_RS06155	COG2233	PERMEase
APT61_RS06165	COG1393	Belongs to the ArsC family
APT61_RS06170	COG4783	chaperone-mediated protein folding
APT61_RS06175	COG0628	permease
APT61_RS06180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT61_RS06185	COG2716	regulation of RNA biosynthetic process
APT61_RS06195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APT61_RS06200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APT61_RS06205	COG2321	neutral zinc metallopeptidase
APT61_RS06215	COG0400	carboxylic ester hydrolase activity
APT61_RS06230	COG1393	Belongs to the ArsC family
APT61_RS06235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT61_RS06240	COG3850	Histidine kinase
APT61_RS06245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT61_RS06245	COG0493	'glutamate synthase
APT61_RS06250	COG0494	nUDIX hydrolase
APT61_RS06255	COG5342	invasion associated locus B
APT61_RS06260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT61_RS06275	COG0408	coproporphyrinogen oxidase activity
APT61_RS06280	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT61_RS06300	COG2837	iron assimilation
APT61_RS06305	COG4150	thiosulfate binding
APT61_RS06310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT61_RS06315	COG4208	sulfate ABC transporter
APT61_RS06320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT61_RS06345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS06360	COG3115	cell septum assembly
APT61_RS06370	COG3530	Putative quorum-sensing-regulated virulence factor
APT61_RS06375	COG0385	Bile acid
APT61_RS06380	COG0583	DNA-binding transcription factor activity
APT61_RS06420	COG3415	Transposase
APT61_RS06425	COG3415	Transposase
APT61_RS06440	COG2200	EAL domain
APT61_RS06440	COG2199	diguanylate cyclase activity
APT61_RS06445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APT61_RS06460	COG0667	Aldo Keto reductase
APT61_RS06465	COG3961	Belongs to the TPP enzyme family
APT61_RS06475	COG0837	glucose binding
APT61_RS06480	COG3279	Response regulator of the LytR AlgR family
APT61_RS06485	COG3275	phosphorelay sensor kinase activity
APT61_RS06490	COG0436	Aminotransferase
APT61_RS06500	COG1560	Kdo2-lipid A biosynthetic process
APT61_RS06515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APT61_RS06535	COG3300	MHYT domain
APT61_RS06535	COG5001	Diguanylate cyclase
APT61_RS06555	COG2274	protein secretion by the type I secretion system
APT61_RS06565	COG3122	Protein conserved in bacteria
APT61_RS06585	COG2116	formate transmembrane transporter activity
APT61_RS06595	COG2067	long-chain fatty acid transport protein
APT61_RS06600	COG3691	Protein conserved in bacteria
APT61_RS06610	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT61_RS06610	COG1024	Enoyl-CoA hydratase
APT61_RS06615	COG2062	phosphohistidine phosphatase, SixA
APT61_RS06630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT61_RS06640	COG0730	response to heat
APT61_RS06645	COG3101	peptidyl-lysine hydroxylation
APT61_RS06655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT61_RS06655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APT61_RS06660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT61_RS06680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT61_RS06685	COG0101	tRNA pseudouridine synthase activity
APT61_RS06690	COG0586	Pfam SNARE associated Golgi protein
APT61_RS06695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT61_RS06700	COG0285	dihydrofolate synthase activity
APT61_RS06705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
APT61_RS06710	COG1286	toxin biosynthetic process
APT61_RS06715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APT61_RS06720	COG0163	prenyltransferase activity
APT61_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS06740	COG4160	amino acid transport
APT61_RS06745	COG4598	ABC transporter
APT61_RS06750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT61_RS06755	COG1090	epimerase
APT61_RS06760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APT61_RS06765	COG0625	glutathione transferase activity
APT61_RS06770	COG0625	glutathione transferase activity
APT61_RS06775	COG0622	Phosphoesterase
APT61_RS06805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT61_RS06810	COG0471	metal ion transport
APT61_RS06810	COG0490	domain, Protein
APT61_RS06820	COG0436	Aminotransferase
APT61_RS06825	COG0583	DNA-binding transcription factor activity
APT61_RS06830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT61_RS06860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APT61_RS06870	COG0839	Belongs to the complex I subunit 6 family
APT61_RS06880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT61_RS06885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT61_RS06890	COG1007	ATP synthesis coupled electron transport
APT61_RS06895	COG0784	Response regulator, receiver
APT61_RS06895	COG0835	chemotaxis
APT61_RS06900	COG1234	tRNA 3'-trailer cleavage
APT61_RS06905	COG2153	protein acetylation
APT61_RS06910	COG4575	ribosome binding
APT61_RS06915	COG1169	isochorismate synthase
APT61_RS06920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APT61_RS06925	COG0596	Alpha beta hydrolase
APT61_RS06935	COG1441	menaquinone biosynthetic process
APT61_RS06955	COG0247	lactate metabolic process
APT61_RS06960	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APT61_RS06965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APT61_RS06970	COG2271	Major facilitator Superfamily
APT61_RS06975	COG0584	glycerophosphoryl diester phosphodiesterase
APT61_RS06980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT61_RS06995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT61_RS07005	COG0784	Response regulator, receiver
APT61_RS07005	COG2205	protein histidine kinase activity
APT61_RS07010	COG2197	response regulator
APT61_RS07015	COG0642	Histidine kinase
APT61_RS07015	COG2198	Histidine kinase
APT61_RS07025	COG1477	protein flavinylation
APT61_RS07030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT61_RS07030	COG2169	Transcriptional regulator
APT61_RS07035	COG3145	DNA-N1-methyladenine dioxygenase activity
APT61_RS07040	COG4615	Cyclic peptide transporter
APT61_RS07045	COG2239	Acts as a magnesium transporter
APT61_RS07050	COG0659	secondary active sulfate transmembrane transporter activity
APT61_RS07055	COG0579	oxidoreductase
APT61_RS07065	COG3182	Iron-regulated membrane protein
APT61_RS07105	COG1061	Type III restriction enzyme res subunit
APT61_RS07110	COG1187	pseudouridine synthase activity
APT61_RS07115	COG2814	Major facilitator Superfamily
APT61_RS07125	COG4172	Belongs to the ABC transporter superfamily
APT61_RS07130	COG4239	(ABC) transporter, permease
APT61_RS07135	COG4174	ABC transporter (Permease)
APT61_RS07145	COG2200	EAL domain
APT61_RS07150	COG0791	NLP P60 protein
APT61_RS07155	COG0671	phosphoesterase, PA-phosphatase related
APT61_RS07160	COG0523	cobalamin synthesis protein
APT61_RS07165	COG0246	Mannitol dehydrogenase
APT61_RS07170	COG1312	Catalyzes the dehydration of D-mannonate
APT61_RS07175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT61_RS07190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS07190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS07195	COG1105	Belongs to the carbohydrate kinase PfkB family
APT61_RS07200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS07200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS07200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APT61_RS07210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APT61_RS07215	COG2855	membrane
APT61_RS07220	COG0583	DNA-binding transcription factor activity
APT61_RS07225	COG0833	amino acid
APT61_RS07230	COG4771	TonB-dependent receptor
APT61_RS07240	COG0477	Major facilitator Superfamily
APT61_RS07250	COG2311	Membrane
APT61_RS07265	COG1129	ABC transporter
APT61_RS07275	COG2949	membrane
APT61_RS07280	COG0295	cytidine deaminase activity
APT61_RS07285	COG1346	cytolysis
APT61_RS07305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT61_RS07320	COG2723	6-phospho-beta-galactosidase activity
APT61_RS07325	COG1538	Outer membrane efflux protein
APT61_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS07335	COG0586	Pfam SNARE associated Golgi protein
APT61_RS07350	COG1686	Belongs to the peptidase S11 family
APT61_RS07360	COG0277	FAD linked oxidase domain protein
APT61_RS07365	COG1472	Belongs to the glycosyl hydrolase 3 family
APT61_RS07370	COG1732	Glycine betaine
APT61_RS07375	COG1174	glycine betaine transport
APT61_RS07380	COG1125	glycine betaine transport
APT61_RS07385	COG1174	glycine betaine transport
APT61_RS07390	COG0789	Transcriptional regulator
APT61_RS07395	COG3275	phosphorelay sensor kinase activity
APT61_RS07405	COG4807	Protein conserved in bacteria
APT61_RS07410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT61_RS07410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT61_RS07415	COG0489	protein tyrosine kinase activity
APT61_RS07420	COG5455	response to cobalt ion
APT61_RS07425	COG1596	polysaccharide export
APT61_RS07430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APT61_RS07440	COG0076	glutamate decarboxylase activity
APT61_RS07445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT61_RS07455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
APT61_RS07460	COG0351	phosphomethylpyrimidine kinase
APT61_RS07465	COG1830	Aldolase
APT61_RS07475	COG1070	Carbohydrate kinase
APT61_RS07500	COG1070	Carbohydrate kinase
APT61_RS07510	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS07515	COG0747	negative chemotaxis
APT61_RS07520	COG0601	transmembrane transport
APT61_RS07525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS07530	COG0444	Belongs to the ABC transporter superfamily
APT61_RS07535	COG4608	Belongs to the ABC transporter superfamily
APT61_RS07540	COG1597	lipid kinase activity
APT61_RS07550	COG0826	peptidase U32
APT61_RS07580	COG2200	EAL domain
APT61_RS07585	COG0789	Transcriptional regulator
APT61_RS07590	COG0745	RESPONSE REGULATOR receiver
APT61_RS07595	COG2205	protein histidine kinase activity
APT61_RS07600	COG0477	Major facilitator Superfamily
APT61_RS07605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT61_RS07610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT61_RS07615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS07620	COG0443	Heat shock 70 kDa protein
APT61_RS07625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APT61_RS07630	COG5002	protein histidine kinase activity
APT61_RS07630	COG3447	MASE1 domain protein
APT61_RS07630	COG5001	Diguanylate cyclase
APT61_RS07640	COG0717	Belongs to the dCTP deaminase family
APT61_RS07645	COG2982	Protein involved in outer membrane biogenesis
APT61_RS07650	COG1253	flavin adenine dinucleotide binding
APT61_RS07655	COG1596	polysaccharide export
APT61_RS07665	COG0489	protein tyrosine kinase activity
APT61_RS07665	COG3206	protein involved in exopolysaccharide biosynthesis
APT61_RS07670	COG0463	Glycosyl transferase, family 2
APT61_RS07675	COG1045	serine acetyltransferase
APT61_RS07680	COG0438	transferase activity, transferring glycosyl groups
APT61_RS07690	COG1216	Glycosyl transferase, family 2
APT61_RS07695	COG0110	maltose O-acetyltransferase activity
APT61_RS07700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APT61_RS07705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT61_RS07710	COG1051	belongs to the nudix hydrolase family
APT61_RS07715	COG0297	glycogen (starch) synthase activity
APT61_RS07725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT61_RS07730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT61_RS07735	COG2244	polysaccharide biosynthetic process
APT61_RS07740	COG2327	Polysaccharide pyruvyl transferase
APT61_RS07745	COG0438	transferase activity, transferring glycosyl groups
APT61_RS07765	COG1091	dTDP-4-dehydrorhamnose reductase activity
APT61_RS07790	COG0438	transferase activity, transferring glycosyl groups
APT61_RS07800	COG0438	transferase activity, transferring glycosyl groups
APT61_RS07805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APT61_RS07830	COG0107	imidazoleglycerol-phosphate synthase activity
APT61_RS07835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT61_RS07840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APT61_RS07850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT61_RS07855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT61_RS07860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT61_RS07865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT61_RS07870	COG0583	DNA-binding transcription factor activity
APT61_RS07875	COG0531	amino acid
APT61_RS07880	COG2925	Exonuclease
APT61_RS07890	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APT61_RS07895	COG1289	transmembrane transporter activity
APT61_RS07910	COG0534	Mate efflux family protein
APT61_RS07920	COG0006	proline dipeptidase activity
APT61_RS07925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APT61_RS07930	COG0477	Major facilitator Superfamily
APT61_RS07935	COG1376	ErfK ybiS ycfS ynhG family protein
APT61_RS07960	COG3228	Belongs to the MtfA family
APT61_RS07970	COG4565	transcriptional regulatory protein
APT61_RS07975	COG3290	protein histidine kinase activity
APT61_RS07980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT61_RS07990	COG1418	mRNA catabolic process
APT61_RS07995	COG0270	DNA (cytosine-5-)-methyltransferase activity
APT61_RS08000	COG3727	T/G mismatch-specific endonuclease activity
APT61_RS08005	COG0697	spore germination
APT61_RS08010	COG2354	Protein conserved in bacteria
APT61_RS08015	COG5475	Uncharacterized small protein (DUF2158)
APT61_RS08040	COG2197	response regulator
APT61_RS08050	COG1987	bacterial-type flagellum assembly
APT61_RS08075	COG1580	Controls the rotational direction of flagella during chemotaxis
APT61_RS08090	COG1157	protein secretion by the type III secretion system
APT61_RS08100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT61_RS08110	COG1677	Flagellar hook-basal body complex protein FliE
APT61_RS08130	COG0366	Alpha amylase catalytic
APT61_RS08145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APT61_RS08155	COG1216	Glycosyl transferase, family 2
APT61_RS08155	COG0438	transferase activity, transferring glycosyl groups
APT61_RS08175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS08185	COG0765	amino acid transport
APT61_RS08190	COG1126	abc transporter atp-binding protein
APT61_RS08195	COG2197	response regulator
APT61_RS08205	COG2197	response regulator
APT61_RS08245	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS08250	COG1129	ABC transporter
APT61_RS08260	COG1305	Transglutaminase-like
APT61_RS08270	COG2608	mercury ion transmembrane transporter activity
APT61_RS08275	COG2194	sulfuric ester hydrolase activity
APT61_RS08295	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT61_RS08305	COG3318	Belongs to the UPF0149 family
APT61_RS08305	COG3012	SEC-C Motif Domain Protein
APT61_RS08310	COG0814	amino acid
APT61_RS08325	COG1528	Iron-storage protein
APT61_RS08350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APT61_RS08355	COG1528	Iron-storage protein
APT61_RS08365	COG1879	ABC-type sugar transport system periplasmic component
APT61_RS08375	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS08385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APT61_RS08425	COG1301	dicarboxylic acid transport
APT61_RS08460	COG0840	transmembrane signaling receptor activity
APT61_RS08475	COG0745	RESPONSE REGULATOR receiver
APT61_RS08490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APT61_RS08505	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APT61_RS08515	COG3102	Protein conserved in bacteria
APT61_RS08520	COG3142	Participates in the control of copper homeostasis
APT61_RS08525	COG0500	methyltransferase
APT61_RS08530	COG2226	methyltransferase
APT61_RS08535	COG3788	relative of glutathione S-transferase, MAPEG superfamily
APT61_RS08540	COG1801	Protein of unknown function DUF72
APT61_RS08545	COG1335	isochorismatase
APT61_RS08550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT61_RS08555	COG0494	nUDIX hydrolase
APT61_RS08575	COG2255	four-way junction helicase activity
APT61_RS08580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT61_RS08590	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APT61_RS08595	COG0739	heme binding
APT61_RS08600	COG1560	Kdo2-lipid A biosynthetic process
APT61_RS08605	COG0469	pyruvate kinase activity
APT61_RS08610	COG1737	Transcriptional regulator
APT61_RS08620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APT61_RS08625	COG0129	dihydroxy-acid dehydratase activity
APT61_RS08630	COG0800	Aldolase
APT61_RS08645	COG2979	Protein of unknown function (DUF533)
APT61_RS08650	COG1770	oligopeptidase
APT61_RS08655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT61_RS08660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT61_RS08670	COG2372	response to copper ion
APT61_RS08675	COG1276	copper resistance
APT61_RS08685	COG2990	Protein conserved in bacteria
APT61_RS08705	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
APT61_RS08705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT61_RS08710	COG3008	intermembrane lipid transfer
APT61_RS08715	COG2995	paraquat-inducible protein a
APT61_RS08720	COG1956	GAF domain-containing protein
APT61_RS08740	COG2814	Major facilitator Superfamily
APT61_RS08745	COG1414	Transcriptional regulator
APT61_RS08775	COG0768	penicillin binding
APT61_RS08780	COG2226	methyltransferase
APT61_RS08785	COG1971	Probably functions as a manganese efflux pump
APT61_RS08790	COG4811	Protein of unknown function (DUF986)
APT61_RS08795	COG3716	PTS system mannose fructose sorbose family IID component
APT61_RS08800	COG3715	PTS system
APT61_RS08805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS08805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS08810	COG1253	flavin adenine dinucleotide binding
APT61_RS08815	COG2200	EAL domain
APT61_RS08820	COG1760	l-serine dehydratase
APT61_RS08825	COG0494	nUDIX hydrolase
APT61_RS08840	COG0251	oxidation-reduction process
APT61_RS08845	COG1199	ATP-dependent helicase activity
APT61_RS08855	COG3065	identical protein binding
APT61_RS08860	COG0318	PFAM AMP-dependent synthetase and ligase
APT61_RS08865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APT61_RS08870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APT61_RS08875	COG2894	cell division
APT61_RS08880	COG0850	regulation of cytokinetic process
APT61_RS08885	COG3100	YcgL domain-containing protein
APT61_RS08890	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT61_RS08895	COG2983	Belongs to the UPF0260 family
APT61_RS08905	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT61_RS08910	COG2186	Transcriptional regulator
APT61_RS08915	COG2719	SpoVR family
APT61_RS08930	COG3263	regulation of cellular component size
APT61_RS08935	COG1619	proteins homologs of microcin C7 resistance protein MccF
APT61_RS08940	COG0741	lytic transglycosylase activity
APT61_RS08980	COG2814	Major facilitator Superfamily
APT61_RS08995	COG0154	amidase activity
APT61_RS09015	COG4638	Rieske (2fe-2S)
APT61_RS09035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT61_RS09045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APT61_RS09050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT61_RS09055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT61_RS09060	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS09070	COG3485	protocatechuate 3,4-dioxygenase
APT61_RS09075	COG2207	Transcriptional regulator
APT61_RS09090	COG4319	ketosteroid isomerase
APT61_RS09100	COG5642	Protein of unknown function (DUF2384)
APT61_RS09105	COG0243	molybdopterin cofactor binding
APT61_RS09115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APT61_RS09125	COG4977	sequence-specific DNA binding
APT61_RS09135	COG2211	Major facilitator Superfamily
APT61_RS09140	COG1874	Beta-galactosidase
APT61_RS09145	COG0012	GTP binding
APT61_RS09150	COG0193	aminoacyl-tRNA hydrolase activity
APT61_RS09165	COG0659	secondary active sulfate transmembrane transporter activity
APT61_RS09175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT61_RS09180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
APT61_RS09185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APT61_RS09190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT61_RS09195	COG2890	protein-(glutamine-N5) methyltransferase activity
APT61_RS09210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APT61_RS09215	COG0387	Pfam Sodium calcium exchanger
APT61_RS09220	COG4572	Cation transport regulator
APT61_RS09225	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
APT61_RS09235	COG0840	transmembrane signaling receptor activity
APT61_RS09240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APT61_RS09245	COG3707	response regulator
APT61_RS09250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT61_RS09260	COG1116	anion transmembrane transporter activity
APT61_RS09265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT61_RS09265	COG2146	nitrite reductase [NAD(P)H] activity
APT61_RS09270	COG0243	molybdopterin cofactor binding
APT61_RS09275	COG4932	domain protein
APT61_RS09280	COG2197	response regulator
APT61_RS09285	COG3850	Histidine kinase
APT61_RS09290	COG2223	nitrite transmembrane transporter activity
APT61_RS09295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APT61_RS09300	COG1140	nitrate reductase beta subunit
APT61_RS09305	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APT61_RS09310	COG2181	nitrate reductase activity
APT61_RS09315	COG0697	spore germination
APT61_RS09320	COG1522	sequence-specific DNA binding
APT61_RS09355	COG0788	formyltetrahydrofolate deformylase activity
APT61_RS09360	COG3012	SEC-C Motif Domain Protein
APT61_RS09365	COG1752	Esterase of the alpha-beta hydrolase superfamily
APT61_RS09370	COG0745	RESPONSE REGULATOR receiver
APT61_RS09375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APT61_RS09380	COG2916	Histone family protein nucleoid-structuring protein H-NS
APT61_RS09390	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS09390	COG1454	alcohol dehydrogenase
APT61_RS09395	COG2095	MarC family integral membrane protein
APT61_RS09405	COG0601	transmembrane transport
APT61_RS09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS09415	COG0444	Belongs to the ABC transporter superfamily
APT61_RS09420	COG4608	Belongs to the ABC transporter superfamily
APT61_RS09425	COG3099	Belongs to the UPF0263 family
APT61_RS09435	COG1280	lysine exporter protein (LysE YggA)
APT61_RS09440	COG2350	Protein conserved in bacteria
APT61_RS09465	COG3047	cAMP biosynthetic process
APT61_RS09475	COG0425	Belongs to the sulfur carrier protein TusA family
APT61_RS09480	COG2391	methyltransferase activity
APT61_RS09485	COG0159	tryptophan synthase activity
APT61_RS09490	COG0133	tryptophan synthase activity
APT61_RS09500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT61_RS09500	COG0512	Glutamine amidotransferase of anthranilate synthase
APT61_RS09505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APT61_RS09515	COG0009	L-threonylcarbamoyladenylate synthase
APT61_RS09530	COG1187	pseudouridine synthase activity
APT61_RS09535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APT61_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS09545	COG0616	signal peptide processing
APT61_RS09565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APT61_RS09575	COG0671	phosphoesterase, PA-phosphatase related
APT61_RS09580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APT61_RS09585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APT61_RS09590	COG0284	orotidine-5'-phosphate decarboxylase activity
APT61_RS09595	COG0023	Translation Initiation Factor
APT61_RS09605	COG1349	DNA-binding transcription factor activity
APT61_RS09615	COG1024	Enoyl-CoA hydratase
APT61_RS09620	COG5001	Diguanylate cyclase
APT61_RS09630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS09630	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS09635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT61_RS09640	COG4172	Belongs to the ABC transporter superfamily
APT61_RS09650	COG4171	peptide transport system, permease
APT61_RS09665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APT61_RS09670	COG1842	Phage shock protein A
APT61_RS09680	COG1983	PspC domain protein
APT61_RS09690	COG0366	Alpha amylase catalytic
APT61_RS09695	COG1653	transport
APT61_RS09705	COG0395	ABC-type sugar transport system, permease component
APT61_RS09710	COG1063	alcohol dehydrogenase
APT61_RS09715	COG1082	Xylose isomerase domain protein TIM barrel
APT61_RS09720	COG0673	inositol 2-dehydrogenase activity
APT61_RS09725	COG1554	hydrolase, family 65, central catalytic
APT61_RS09730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT61_RS09735	COG3842	ATPase activity
APT61_RS09745	COG1609	Transcriptional regulator
APT61_RS09750	COG3106	COG3106 Predicted ATPase
APT61_RS09755	COG3768	UPF0283 membrane protein
APT61_RS09765	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APT61_RS09770	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS09775	COG2866	Carboxypeptidase
APT61_RS09780	COG4166	transmembrane transport
APT61_RS09785	COG0702	epimerase
APT61_RS09820	COG2885	chlorophyll binding
APT61_RS09850	COG0515	serine threonine protein kinase
APT61_RS09850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT61_RS09855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT61_RS09855	COG0515	serine threonine protein kinase
APT61_RS09860	COG0515	serine threonine protein kinase
APT61_RS09860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT61_RS09865	COG0515	serine threonine protein kinase
APT61_RS09865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT61_RS09915	COG0693	protein deglycase activity
APT61_RS09920	COG3706	GGDEF domain
APT61_RS09925	COG0840	transmembrane signaling receptor activity
APT61_RS09935	COG0513	Belongs to the DEAD box helicase family
APT61_RS09960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT61_RS09965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT61_RS09965	COG1013	pyruvate-flavodoxin oxidoreductase activity
APT61_RS09965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APT61_RS09965	COG0674	pyruvate-flavodoxin oxidoreductase activity
APT61_RS09970	COG3042	response to heat
APT61_RS09975	COG3187	Heat shock protein
APT61_RS09980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT61_RS09990	COG2911	Protein conserved in bacteria
APT61_RS10000	COG3784	Protein of unknown function (DUF1318)
APT61_RS10005	COG2207	Transcriptional regulator
APT61_RS10010	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS10020	COG2030	dehydratase
APT61_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS10025	COG3396	Phenylacetate-CoA oxygenase
APT61_RS10030	COG3460	Phenylacetate-CoA oxygenase
APT61_RS10035	COG3396	Phenylacetate-CoA oxygenase
APT61_RS10040	COG2151	metal-sulfur cluster biosynthetic enzyme
APT61_RS10045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT61_RS10050	COG1024	Enoyl-CoA hydratase
APT61_RS10055	COG1024	Enoyl-CoA hydratase
APT61_RS10060	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT61_RS10065	COG2050	protein possibly involved in aromatic compounds catabolism
APT61_RS10070	COG0183	Belongs to the thiolase family
APT61_RS10075	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
APT61_RS10080	COG3327	negative regulation of DNA-templated transcription, initiation
APT61_RS10085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APT61_RS10090	COG3250	beta-galactosidase activity
APT61_RS10140	COG1366	Belongs to the anti-sigma-factor antagonist family
APT61_RS10155	COG1643	Atp-dependent helicase
APT61_RS10160	COG4122	O-methyltransferase activity
APT61_RS10185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APT61_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS10205	COG2755	lipolytic protein G-D-S-L family
APT61_RS10205	COG0657	acetylesterase activity
APT61_RS10210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT61_RS10215	COG3038	cytochrome b561
APT61_RS10220	COG0477	Major facilitator Superfamily
APT61_RS10230	COG3729	General stress protein
APT61_RS10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS10240	COG0697	spore germination
APT61_RS10250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT61_RS10265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT61_RS10270	COG2135	peptidase activity
APT61_RS10280	COG3387	PFAM Glycoside hydrolase 15-related
APT61_RS10290	COG0640	Transcriptional regulator
APT61_RS10295	COG1902	pentaerythritol trinitrate reductase activity
APT61_RS10300	COG1902	pentaerythritol trinitrate reductase activity
APT61_RS10305	COG4221	oxidoreductase activity
APT61_RS10320	COG4993	Dehydrogenase
APT61_RS10325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT61_RS10355	COG0814	amino acid
APT61_RS10360	COG1114	Component of the transport system for branched-chain amino acids
APT61_RS10375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS10410	COG2814	Major facilitator Superfamily
APT61_RS10430	COG0477	Major facilitator Superfamily
APT61_RS10440	COG1522	sequence-specific DNA binding
APT61_RS10445	COG2814	Major facilitator Superfamily
APT61_RS10450	COG0384	phenazine biosynthesis protein PhzF
APT61_RS10505	COG0840	transmembrane signaling receptor activity
APT61_RS10520	COG0583	DNA-binding transcription factor activity
APT61_RS10525	COG5383	Protein conserved in bacteria
APT61_RS10530	COG2272	Belongs to the type-B carboxylesterase lipase family
APT61_RS10540	COG0436	Aminotransferase
APT61_RS10550	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APT61_RS10555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT61_RS10560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APT61_RS10565	COG1275	C4-dicarboxylate transporter malic acid transport protein
APT61_RS10570	COG0500	methyltransferase
APT61_RS10595	COG2195	Cleaves the N-terminal amino acid of tripeptides
APT61_RS10600	COG0747	negative chemotaxis
APT61_RS10620	COG3135	benzoate transporter
APT61_RS10625	COG1396	sequence-specific DNA binding
APT61_RS10630	COG0826	peptidase U32
APT61_RS10640	COG1294	oxidase, subunit
APT61_RS10645	COG1271	oxidase subunit
APT61_RS10660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS10665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS10670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APT61_RS10675	COG3842	ATPase activity
APT61_RS10680	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT61_RS10685	COG1177	transmembrane transport
APT61_RS10690	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS10705	COG3615	Tellurite resistance protein tehB
APT61_RS10730	COG0747	negative chemotaxis
APT61_RS10740	COG3238	Protein conserved in bacteria
APT61_RS10745	COG1247	-acetyltransferase
APT61_RS10750	COG1396	sequence-specific DNA binding
APT61_RS10755	COG2130	NADP-dependent
APT61_RS10760	COG1802	Transcriptional regulator
APT61_RS10765	COG4772	TonB-dependent receptor
APT61_RS10775	COG1309	transcriptional regulator
APT61_RS10780	COG0251	oxidation-reduction process
APT61_RS10790	COG0667	Aldo Keto reductase
APT61_RS10815	COG0840	transmembrane signaling receptor activity
APT61_RS10820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT61_RS10825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS10830	COG1473	amidohydrolase
APT61_RS10835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS10855	COG1126	abc transporter atp-binding protein
APT61_RS10865	COG0625	glutathione transferase activity
APT61_RS10870	COG1942	4-Oxalocrotonate Tautomerase
APT61_RS10935	COG0583	DNA-binding transcription factor activity
APT61_RS10940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT61_RS10945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT61_RS10955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT61_RS10965	COG1840	ABC-type Fe3 transport system, periplasmic component
APT61_RS10970	COG1178	ABC-type Fe3 transport system permease component
APT61_RS10975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
APT61_RS10980	COG2337	Toxic component of a toxin-antitoxin (TA) module
APT61_RS10985	COG2336	PFAM SpoVT AbrB
APT61_RS10990	COG2181	nitrate reductase activity
APT61_RS10995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APT61_RS11000	COG1140	nitrate reductase beta subunit
APT61_RS11005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APT61_RS11060	COG0583	DNA-binding transcription factor activity
APT61_RS11090	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS11090	COG0243	molybdopterin cofactor binding
APT61_RS11095	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS11095	COG0243	molybdopterin cofactor binding
APT61_RS11100	COG0437	4 iron, 4 sulfur cluster binding
APT61_RS11105	COG2864	formate dehydrogenase
APT61_RS11115	COG2814	Major facilitator Superfamily
APT61_RS11135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS11145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS11160	COG1252	NADH dehydrogenase
APT61_RS11170	COG1064	alcohol dehydrogenase
APT61_RS11180	COG0488	(ABC) transporter
APT61_RS11185	COG2814	Major facilitator Superfamily
APT61_RS11190	COG1403	HNH endonuclease
APT61_RS11195	COG0281	malic enzyme
APT61_RS11215	COG1764	response to oxidative stress
APT61_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS11235	COG2200	EAL domain
APT61_RS11240	COG0840	transmembrane signaling receptor activity
APT61_RS11245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT61_RS11260	COG4628	conserved protein (DUF2132)
APT61_RS11265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT61_RS11280	COG1649	PFAM Uncharacterised BCR, COG1649
APT61_RS11285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APT61_RS11310	COG1396	sequence-specific DNA binding
APT61_RS11315	COG3550	peptidyl-serine autophosphorylation
APT61_RS11325	COG4771	TonB-dependent receptor
APT61_RS11330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS11340	COG2814	Major facilitator Superfamily
APT61_RS11350	COG0406	alpha-ribazole phosphatase activity
APT61_RS11370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APT61_RS11375	COG2999	glutathione oxidoreductase activity
APT61_RS11405	COG1349	DNA-binding transcription factor activity
APT61_RS11410	COG0494	nUDIX hydrolase
APT61_RS11425	COG2205	protein histidine kinase activity
APT61_RS11435	COG0596	Alpha beta hydrolase
APT61_RS11440	COG3781	membrane
APT61_RS11445	COG0246	Mannitol dehydrogenase
APT61_RS11465	COG2199	diguanylate cyclase activity
APT61_RS11470	COG2066	Belongs to the glutaminase family
APT61_RS11475	COG0840	transmembrane signaling receptor activity
APT61_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS11485	COG0583	DNA-binding transcription factor activity
APT61_RS11495	COG0039	L-malate dehydrogenase activity
APT61_RS11500	COG1349	DNA-binding transcription factor activity
APT61_RS11505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT61_RS11510	COG3395	kinase activity
APT61_RS11515	COG1454	alcohol dehydrogenase
APT61_RS11520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT61_RS11560	COG2814	Major facilitator Superfamily
APT61_RS11570	COG1846	Transcriptional regulator
APT61_RS11585	COG0697	spore germination
APT61_RS11590	COG2814	Major facilitator Superfamily
APT61_RS11610	COG3443	Belongs to the bacterial solute-binding protein 9 family
APT61_RS11620	COG1122	ATPase activity
APT61_RS11640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT61_RS11650	COG0456	acetyltransferase
APT61_RS11670	COG2814	Major facilitator Superfamily
APT61_RS11675	COG0583	DNA-binding transcription factor activity
APT61_RS11685	COG4221	oxidoreductase activity
APT61_RS11690	COG1802	Transcriptional regulator
APT61_RS11705	COG0246	Mannitol dehydrogenase
APT61_RS11710	COG0477	Major facilitator Superfamily
APT61_RS11715	COG1063	alcohol dehydrogenase
APT61_RS11720	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS11725	COG1742	UPF0060 membrane protein
APT61_RS11745	COG0243	molybdopterin cofactor binding
APT61_RS11750	COG0437	4 iron, 4 sulfur cluster binding
APT61_RS11755	COG3302	dmso reductase anchor subunit
APT61_RS11760	COG3381	protein complex oligomerization
APT61_RS11770	COG4770	biotin carboxylase activity
APT61_RS11775	COG3665	Urea carboxylase-associated protein
APT61_RS11785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT61_RS11785	COG1116	anion transmembrane transporter activity
APT61_RS11800	COG0583	DNA-binding transcription factor activity
APT61_RS11825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS11835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APT61_RS11840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS11845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS11850	COG0583	DNA-binding transcription factor activity
APT61_RS11870	COG2267	carboxylic ester hydrolase activity
APT61_RS11875	COG4977	sequence-specific DNA binding
APT61_RS11885	COG2267	carboxylic ester hydrolase activity
APT61_RS11895	COG1215	transferase activity, transferring glycosyl groups
APT61_RS11900	COG1649	PFAM Uncharacterised BCR, COG1649
APT61_RS11900	COG0726	polysaccharide deacetylase
APT61_RS11905	COG0457	Tetratricopeptide repeat
APT61_RS11930	COG1309	transcriptional regulator
APT61_RS11935	COG0667	Aldo Keto reductase
APT61_RS11970	COG0386	Belongs to the glutathione peroxidase family
APT61_RS11975	COG3141	response to X-ray
APT61_RS11985	COG0625	glutathione transferase activity
APT61_RS12020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT61_RS12025	COG1940	carbohydrate kinase activity
APT61_RS12030	COG0583	DNA-binding transcription factor activity
APT61_RS12035	COG2814	Major facilitator Superfamily
APT61_RS12040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
APT61_RS12050	COG3591	Belongs to the peptidase S1B family
APT61_RS12055	COG5001	Diguanylate cyclase
APT61_RS12070	COG0628	permease
APT61_RS12080	COG2840	Smr protein MutS2
APT61_RS12085	COG0583	DNA-binding transcription factor activity
APT61_RS12095	COG1473	amidohydrolase
APT61_RS12100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APT61_RS12105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT61_RS12120	COG0668	transmembrane transport
APT61_RS12125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APT61_RS12130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT61_RS12140	COG0531	amino acid
APT61_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS12150	COG3136	membrane protein required for alginate biosynthesis
APT61_RS12155	COG0745	RESPONSE REGULATOR receiver
APT61_RS12165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS12175	COG2205	protein histidine kinase activity
APT61_RS12185	COG0114	fumarate hydratase activity
APT61_RS12190	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APT61_RS12190	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APT61_RS12195	COG1482	cell wall glycoprotein biosynthetic process
APT61_RS12200	COG5339	Protein conserved in bacteria
APT61_RS12205	COG1609	Transcriptional regulator
APT61_RS12210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS12210	COG1263	PTS System
APT61_RS12215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APT61_RS12285	COG1196	nuclear chromosome segregation
APT61_RS12360	COG5484	DNA packaging
APT61_RS12360	COG3728	DNA packaging
APT61_RS12400	COG0484	heat shock protein binding
APT61_RS12410	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APT61_RS12455	COG1484	DNA-dependent DNA replication
APT61_RS12495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT61_RS12515	COG0582	viral genome integration into host DNA
APT61_RS12525	COG0673	inositol 2-dehydrogenase activity
APT61_RS12575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT61_RS12580	COG3104	oligopeptide transport
APT61_RS12585	COG0625	glutathione transferase activity
APT61_RS12590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APT61_RS12600	COG0259	pyridoxamine-phosphate oxidase activity
APT61_RS12605	COG3895	Periplasmic Protein
APT61_RS12610	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APT61_RS12620	COG3706	GGDEF domain
APT61_RS12635	COG1566	PFAM secretion protein HlyD family protein
APT61_RS12640	COG1289	transmembrane transporter activity
APT61_RS12645	COG2032	superoxide dismutase activity
APT61_RS12650	COG4989	oxidoreductase activity
APT61_RS12660	COG2194	sulfuric ester hydrolase activity
APT61_RS12665	COG1309	transcriptional regulator
APT61_RS12670	COG1902	pentaerythritol trinitrate reductase activity
APT61_RS12675	COG0346	lactoylglutathione lyase activity
APT61_RS12680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT61_RS12685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APT61_RS12690	COG0791	NLP P60 protein
APT61_RS12700	COG2814	Major facilitator Superfamily
APT61_RS12710	COG0583	DNA-binding transcription factor activity
APT61_RS12715	COG2814	Major facilitator Superfamily
APT61_RS12720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT61_RS12725	COG0307	riboflavin synthase, alpha
APT61_RS12730	COG0534	Mate efflux family protein
APT61_RS12755	COG0437	4 iron, 4 sulfur cluster binding
APT61_RS12760	COG0243	molybdopterin cofactor binding
APT61_RS12765	COG4529	Protein conserved in bacteria
APT61_RS12770	COG0154	amidase activity
APT61_RS12775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT61_RS12795	COG2814	Major facilitator Superfamily
APT61_RS12800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT61_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS12810	COG0596	Alpha beta hydrolase
APT61_RS12830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT61_RS12845	COG4191	Histidine kinase
APT61_RS12855	COG1464	Belongs to the NlpA lipoprotein family
APT61_RS12860	COG2011	ABC-type metal ion transport system permease component
APT61_RS12880	COG1376	ErfK ybiS ycfS ynhG family protein
APT61_RS12885	COG2166	iron-sulfur cluster assembly
APT61_RS12890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT61_RS12895	COG0719	Fe-S assembly protein
APT61_RS12900	COG0396	ATPase activity
APT61_RS12905	COG0719	Fe-S assembly protein
APT61_RS12910	COG0316	Belongs to the HesB IscA family
APT61_RS12915	COG2050	protein possibly involved in aromatic compounds catabolism
APT61_RS12920	COG0247	lactate metabolic process
APT61_RS12920	COG0277	FAD linked oxidase domain protein
APT61_RS12925	COG0628	permease
APT61_RS12935	COG0574	Belongs to the PEP-utilizing enzyme family
APT61_RS12935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT61_RS12940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APT61_RS12945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT61_RS12950	COG4256	Hemin uptake protein
APT61_RS12955	COG4771	TonB-dependent receptor
APT61_RS12960	COG3720	iron ion transport
APT61_RS12965	COG4558	Periplasmic binding protein
APT61_RS12970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS12980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APT61_RS12990	COG0791	NLP P60 protein
APT61_RS13000	COG0386	Belongs to the glutathione peroxidase family
APT61_RS13010	COG0776	regulation of translation
APT61_RS13015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT61_RS13015	COG0072	phenylalanine-tRNA ligase activity
APT61_RS13020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT61_RS13040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT61_RS13050	COG3137	Salt-induced outer membrane protein
APT61_RS13055	COG1105	Belongs to the carbohydrate kinase PfkB family
APT61_RS13065	COG3001	Fructosamine kinase
APT61_RS13075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT61_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS13085	COG1988	membrane-bound metal-dependent
APT61_RS13090	COG1823	symporter activity
APT61_RS13100	COG0753	catalase activity
APT61_RS13105	COG3394	polysaccharide catabolic process
APT61_RS13110	COG1486	melibiose metabolic process
APT61_RS13115	COG1917	Cupin 2, conserved barrel domain protein
APT61_RS13115	COG2169	Transcriptional regulator
APT61_RS13120	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT61_RS13125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT61_RS13130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT61_RS13135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT61_RS13145	COG0322	excinuclease ABC activity
APT61_RS13155	COG3678	ATP-independent chaperone mediated protein folding
APT61_RS13165	COG3724	N-succinylarginine dihydrolase activity
APT61_RS13170	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS13175	COG3138	arginine N-succinyltransferase
APT61_RS13185	COG0708	Exodeoxyribonuclease III
APT61_RS13195	COG4134	Bacterial extracellular solute-binding protein
APT61_RS13200	COG4135	transport system, permease component
APT61_RS13205	COG4136	ATPase activity
APT61_RS13210	COG2897	thiosulfate sulfurtransferase activity
APT61_RS13215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APT61_RS13220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS13225	COG0494	nUDIX hydrolase
APT61_RS13240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APT61_RS13245	COG0709	Synthesizes selenophosphate from selenide and ATP
APT61_RS13250	COG0778	Nitroreductase
APT61_RS13255	COG0616	signal peptide processing
APT61_RS13260	COG0252	asparaginase activity
APT61_RS13265	COG1335	isochorismatase
APT61_RS13270	COG3139	Protein of unknown function (DUF1315)
APT61_RS13290	COG0656	L-ascorbic acid biosynthetic process
APT61_RS13305	COG1278	Cold shock
APT61_RS13315	COG3459	Glycosyltransferase 36 associated
APT61_RS13345	COG1196	nuclear chromosome segregation
APT61_RS13400	COG3561	AntA/AntB antirepressor
APT61_RS13425	COG3713	MltA-interacting MipA family protein
APT61_RS13430	COG2766	serine protein kinase
APT61_RS13435	COG2718	Belongs to the UPF0229 family
APT61_RS13445	COG3706	GGDEF domain
APT61_RS13450	COG2707	UPF0756 membrane protein
APT61_RS13455	COG2207	Transcriptional regulator
APT61_RS13460	COG2807	transmembrane transport
APT61_RS13465	COG0504	CTP synthase activity
APT61_RS13470	COG3189	MarR family transcriptional regulator
APT61_RS13480	COG2203	Gaf domain
APT61_RS13480	COG2199	diguanylate cyclase activity
APT61_RS13485	COG2261	transglycosylase associated protein
APT61_RS13495	COG0457	Tetratricopeptide repeat
APT61_RS13540	COG2200	EAL domain
APT61_RS13595	COG1196	nuclear chromosome segregation
APT61_RS13635	COG0740	serine-type endopeptidase activity
APT61_RS13675	COG3772	lysozyme
APT61_RS13690	COG1403	HNH endonuclease
APT61_RS13760	COG1959	2 iron, 2 sulfur cluster binding
APT61_RS13765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT61_RS13775	COG0582	viral genome integration into host DNA
APT61_RS13780	COG0538	isocitrate dehydrogenase activity
APT61_RS13785	COG1187	pseudouridine synthase activity
APT61_RS13800	COG2915	High frequency lysogenization protein hflD homolog
APT61_RS13805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APT61_RS13820	COG2850	peptidyl-arginine hydroxylation
APT61_RS13860	COG4591	ABC-type transport system involved in lipoprotein release permease component
APT61_RS13865	COG1136	(ABC) transporter
APT61_RS13870	COG4591	ABC-type transport system involved in lipoprotein release permease component
APT61_RS13875	COG4763	Acyl-transferase
APT61_RS13880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT61_RS13885	COG1388	LysM domain
APT61_RS13885	COG1376	ErfK ybiS ycfS ynhG family protein
APT61_RS13895	COG1309	transcriptional regulator
APT61_RS13900	COG3134	Outer membrane lipoprotein
APT61_RS13905	COG1252	NADH dehydrogenase
APT61_RS13910	COG3150	esterase
APT61_RS13925	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
APT61_RS13930	COG5633	Lipoprotein
APT61_RS13935	COG0537	adenosine 5'-monophosphoramidase activity
APT61_RS13940	COG4773	Receptor
APT61_RS13950	COG0084	hydrolase, TatD family'
APT61_RS13955	COG0470	DNA polymerase III
APT61_RS13965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT61_RS13970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT61_RS13975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT61_RS13980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT61_RS13995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT61_RS14000	COG0416	fatty acid biosynthetic process
APT61_RS14005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APT61_RS14020	COG0564	pseudouridine synthase activity
APT61_RS14025	COG1530	ribonuclease E activity
APT61_RS14030	COG0583	DNA-binding transcription factor activity
APT61_RS14035	COG2814	Major facilitator Superfamily
APT61_RS14040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APT61_RS14045	COG1256	bacterial-type flagellum assembly
APT61_RS14075	COG1749	Flagellar hook protein flgE
APT61_RS14080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APT61_RS14085	COG1558	bacterial-type flagellum-dependent cell motility
APT61_RS14110	COG0728	peptidoglycan biosynthetic process
APT61_RS14115	COG0673	inositol 2-dehydrogenase activity
APT61_RS14120	COG3132	Protein of unknown function, DUF480
APT61_RS14125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT61_RS14160	COG3038	cytochrome b561
APT61_RS14165	COG2353	YceI-like domain
APT61_RS14170	COG1054	Belongs to the UPF0176 family
APT61_RS14175	COG1560	Kdo2-lipid A biosynthetic process
APT61_RS14190	COG5645	(Lipo)protein
APT61_RS14195	COG2943	transferase activity, transferring hexosyl groups
APT61_RS14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT61_RS14215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APT61_RS14235	COG2197	response regulator
APT61_RS14260	COG3381	protein complex oligomerization
APT61_RS14265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
APT61_RS14270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT61_RS14300	COG0583	DNA-binding transcription factor activity
APT61_RS14310	COG1335	isochorismatase
APT61_RS14335	COG1702	phosphate starvation-inducible protein PhoH
APT61_RS14345	COG2822	iron ion transport
APT61_RS14355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APT61_RS14365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT61_RS14370	COG0506	proline dehydrogenase activity
APT61_RS14370	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT61_RS14370	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT61_RS14380	COG1309	transcriptional regulator
APT61_RS14400	COG2267	carboxylic ester hydrolase activity
APT61_RS14405	COG0778	Nitroreductase
APT61_RS14410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT61_RS14415	COG2233	PERMEase
APT61_RS14455	COG3300	MHYT domain
APT61_RS14455	COG5001	Diguanylate cyclase
APT61_RS14480	COG0583	DNA-binding transcription factor activity
APT61_RS14485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT61_RS14490	COG1917	Cupin 2, conserved barrel domain protein
APT61_RS14490	COG4977	sequence-specific DNA binding
APT61_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS14565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APT61_RS14570	COG0583	DNA-binding transcription factor activity
APT61_RS14575	COG1902	pentaerythritol trinitrate reductase activity
APT61_RS14585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS14600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT61_RS14610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS14615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS14625	COG1175	transmembrane transport
APT61_RS14630	COG3842	ATPase activity
APT61_RS14645	COG1609	Transcriptional regulator
APT61_RS14660	COG4580	involved in the transport of maltose and maltodextrins
APT61_RS14665	COG2211	Major facilitator Superfamily
APT61_RS14670	COG3507	Belongs to the glycosyl hydrolase 43 family
APT61_RS14680	COG0673	inositol 2-dehydrogenase activity
APT61_RS14685	COG2084	Dehydrogenase
APT61_RS14690	COG1609	Transcriptional regulator
APT61_RS14705	COG0670	Belongs to the BI1 family
APT61_RS14710	COG2920	part of a sulfur-relay system
APT61_RS14715	COG1254	Belongs to the acylphosphatase family
APT61_RS14720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APT61_RS14730	COG1832	CoA-binding protein
APT61_RS14735	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
APT61_RS14740	COG1803	Methylglyoxal synthase
APT61_RS14745	COG0210	DNA helicase
APT61_RS14750	COG3304	Inner membrane component domain
APT61_RS14755	COG1289	transmembrane transporter activity
APT61_RS14760	COG3070	regulator of competence-specific genes
APT61_RS14775	COG3120	sequence-specific DNA binding
APT61_RS14780	COG1067	ATP-dependent peptidase activity
APT61_RS14790	COG3009	Protein conserved in bacteria
APT61_RS14795	COG3008	intermembrane lipid transfer
APT61_RS14795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APT61_RS14800	COG2995	paraquat-inducible protein a
APT61_RS14805	COG0488	(ABC) transporter
APT61_RS14810	COG0116	Belongs to the methyltransferase superfamily
APT61_RS14810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APT61_RS14815	COG0633	Ferredoxin
APT61_RS14815	COG3217	Mosc domain protein beta barrel domain protein
APT61_RS14825	COG0167	dihydroorotate dehydrogenase activity
APT61_RS14830	COG0431	NADPH-dependent FMN reductase
APT61_RS14835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT61_RS14840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT61_RS14845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT61_RS14850	COG1116	anion transmembrane transporter activity
APT61_RS14855	COG0308	aminopeptidase N
APT61_RS14860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APT61_RS14870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT61_RS14875	COG1448	Aminotransferase
APT61_RS14880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT61_RS14885	COG3108	Peptidase M15
APT61_RS14890	COG2989	Protein conserved in bacteria
APT61_RS14900	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APT61_RS14910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT61_RS14915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APT61_RS14920	COG3173	Aminoglycoside phosphotransferase
APT61_RS14925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APT61_RS14930	COG2835	tetraacyldisaccharide 4'-kinase activity
APT61_RS14935	COG3214	Protein conserved in bacteria
APT61_RS14950	COG0658	competence protein
APT61_RS14950	COG2333	competence protein COMEC
APT61_RS14960	COG0539	negative regulation of cytoplasmic translation
APT61_RS14965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT61_RS14970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APT61_RS14975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APT61_RS14980	COG2323	membrane
APT61_RS14985	COG1944	ATP diphosphatase activity
APT61_RS14990	COG2116	formate transmembrane transporter activity
APT61_RS14995	COG1882	Formate acetyltransferase
APT61_RS15000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT61_RS15010	COG0477	Major facilitator Superfamily
APT61_RS15015	COG3302	dmso reductase anchor subunit
APT61_RS15020	COG0437	4 iron, 4 sulfur cluster binding
APT61_RS15025	COG0243	molybdopterin cofactor binding
APT61_RS15030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT61_RS15035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT61_RS15040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APT61_RS15045	COG1674	ftsk spoiiie
APT61_RS15045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT61_RS15055	COG0492	ferredoxin-NADP+ reductase activity
APT61_RS15060	COG4988	ABC transporter
APT61_RS15065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APT61_RS15070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APT61_RS15085	COG0542	response to heat
APT61_RS15090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT61_RS15095	COG1278	Cold shock
APT61_RS15105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS15110	COG2990	Protein conserved in bacteria
APT61_RS15115	COG3593	DNA synthesis involved in DNA repair
APT61_RS15125	COG2431	L-lysine efflux transmembrane transporter activity
APT61_RS15135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT61_RS15145	COG0028	Belongs to the TPP enzyme family
APT61_RS15150	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APT61_RS15155	COG0702	epimerase
APT61_RS15160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT61_RS15175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APT61_RS15200	COG2165	general secretion pathway protein
APT61_RS15210	COG2165	general secretion pathway protein
APT61_RS15215	COG1459	type II secretion system
APT61_RS15220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APT61_RS15225	COG1450	Type ii and iii secretion system protein
APT61_RS15230	COG3031	protein transport across the cell outer membrane
APT61_RS15250	COG3023	N-Acetylmuramoyl-L-alanine amidase
APT61_RS15255	COG0393	Putative heavy-metal-binding
APT61_RS15265	COG1126	abc transporter atp-binding protein
APT61_RS15270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS15275	COG4215	(ABC) transporter
APT61_RS15280	COG4160	amino acid transport
APT61_RS15285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS15290	COG5002	protein histidine kinase activity
APT61_RS15295	COG0745	RESPONSE REGULATOR receiver
APT61_RS15300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT61_RS15310	COG1177	transmembrane transport
APT61_RS15315	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT61_RS15320	COG3842	ATPase activity
APT61_RS15325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APT61_RS15355	COG0569	domain protein
APT61_RS15355	COG2985	domain, Protein
APT61_RS15410	COG3226	Transcriptional regulator
APT61_RS15415	COG0738	Major facilitator superfamily
APT61_RS15420	COG0561	phosphatase activity
APT61_RS15425	COG2814	Major facilitator Superfamily
APT61_RS15435	COG0671	phosphoesterase, PA-phosphatase related
APT61_RS15440	COG1349	DNA-binding transcription factor activity
APT61_RS15445	COG1686	Belongs to the peptidase S11 family
APT61_RS15450	COG0625	glutathione transferase activity
APT61_RS15455	COG2133	pyrroloquinoline quinone binding
APT61_RS15470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT61_RS15475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT61_RS15480	COG3716	PTS system mannose fructose sorbose family IID component
APT61_RS15485	COG3715	PTS system
APT61_RS15515	COG4993	Dehydrogenase
APT61_RS15525	COG0778	Nitroreductase
APT61_RS15545	COG0747	negative chemotaxis
APT61_RS15555	COG1446	asparaginase
APT61_RS15560	COG0303	'Molybdopterin
APT61_RS15565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT61_RS15570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT61_RS15575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT61_RS15580	COG1882	Formate acetyltransferase
APT61_RS15585	COG0561	phosphatase activity
APT61_RS15595	COG0488	(ABC) transporter
APT61_RS15600	COG1376	ErfK ybiS ycfS ynhG family protein
APT61_RS15605	COG0667	Aldo Keto reductase
APT61_RS15615	COG2814	Major facilitator Superfamily
APT61_RS15620	COG1566	PFAM secretion protein HlyD family protein
APT61_RS15625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APT61_RS15640	COG2194	sulfuric ester hydrolase activity
APT61_RS15645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT61_RS15655	COG0783	Belongs to the Dps family
APT61_RS15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT61_RS15665	COG0765	amino acid transport
APT61_RS15670	COG1126	abc transporter atp-binding protein
APT61_RS15675	COG0668	transmembrane transport
APT61_RS15680	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
APT61_RS15690	COG4774	siderophore transport
APT61_RS15700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APT61_RS15710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT61_RS15715	COG3539	Fimbrial protein
APT61_RS15720	COG3121	Chaperone
APT61_RS15740	COG1199	ATP-dependent helicase activity
APT61_RS15745	COG0513	Belongs to the DEAD box helicase family
APT61_RS15750	COG1309	transcriptional regulator
APT61_RS15755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS15760	COG1131	(ABC) transporter
APT61_RS15765	COG0842	Transport permease protein
APT61_RS15770	COG0842	Transport permease protein
APT61_RS15780	COG3568	Endonuclease Exonuclease Phosphatase
APT61_RS15785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT61_RS15790	COG0392	lysyltransferase activity
APT61_RS15795	COG0670	Belongs to the BI1 family
APT61_RS15800	COG0314	molybdopterin synthase activity
APT61_RS15805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APT61_RS15810	COG0315	cyclic pyranopterin monophosphate synthase activity
APT61_RS15815	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT61_RS15825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APT61_RS15835	COG0410	ABC transporter
APT61_RS15850	COG0156	8-amino-7-oxononanoate synthase activity
APT61_RS15860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT61_RS15865	COG1881	PFAM PEBP family protein
APT61_RS15870	COG2986	histidine ammonia-lyase
APT61_RS15875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APT61_RS15885	COG0010	Belongs to the arginase family
APT61_RS15895	COG4677	pectinesterase activity
APT61_RS15900	COG2706	6-phosphogluconolactonase activity
APT61_RS15905	COG0561	phosphatase activity
APT61_RS15915	COG4149	molybdate abc transporter
APT61_RS15920	COG0725	ABC transporter, periplasmic molybdate-binding protein
APT61_RS15925	COG3585	molybdate ion transport
APT61_RS15925	COG2005	Transcriptional regulator
APT61_RS15930	COG1119	ATPase activity
APT61_RS15935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT61_RS15940	COG1085	galactose-1-phosphate uridylyltransferase
APT61_RS15950	COG2017	converts alpha-aldose to the beta-anomer
APT61_RS15955	COG0588	phosphoglycerate mutase activity
APT61_RS15960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT61_RS15970	COG1230	cation diffusion facilitator family transporter
APT61_RS15980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APT61_RS16020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
APT61_RS16025	COG2885	chlorophyll binding
APT61_RS16030	COG0823	Involved in the tonB-independent uptake of proteins
APT61_RS16035	COG3064	Membrane
APT61_RS16040	COG0848	biopolymer transport protein
APT61_RS16045	COG0811	peptide transport
APT61_RS16050	COG0824	Thioesterase
APT61_RS16055	COG3790	cyd operon protein YbgE
APT61_RS16060	COG4890	Cyd operon protein YbgT
APT61_RS16065	COG1294	oxidase, subunit
APT61_RS16070	COG1271	oxidase subunit
APT61_RS16075	COG0383	alpha-mannosidase activity
APT61_RS16080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS16080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT61_RS16080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS16085	COG2188	Transcriptional regulator
APT61_RS16090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APT61_RS16095	COG0045	succinate-CoA ligase (ADP-forming) activity
APT61_RS16100	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT61_RS16105	COG0567	Dehydrogenase, E1 component
APT61_RS16110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT61_RS16115	COG1053	succinate dehydrogenase
APT61_RS16120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APT61_RS16140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APT61_RS16160	COG1984	allophanate hydrolase subunit 2
APT61_RS16165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APT61_RS16170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APT61_RS16175	COG0415	Belongs to the DNA photolyase family
APT61_RS16190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APT61_RS16195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APT61_RS16200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APT61_RS16205	COG2205	protein histidine kinase activity
APT61_RS16210	COG0745	RESPONSE REGULATOR receiver
APT61_RS16215	COG0033	Phosphoglucomutase
APT61_RS16220	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APT61_RS16225	COG0596	Alpha beta hydrolase
APT61_RS16235	COG0716	FMN binding
APT61_RS16240	COG0735	belongs to the Fur family
APT61_RS16255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT61_RS16260	COG1263	PTS System
APT61_RS16260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS16260	COG2190	(PTS) system
APT61_RS16270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APT61_RS16275	COG1940	carbohydrate kinase activity
APT61_RS16275	COG1846	Transcriptional regulator
APT61_RS16280	COG0647	UMP catabolic process
APT61_RS16285	COG0367	asparagine synthase
APT61_RS16325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT61_RS16335	COG1702	phosphate starvation-inducible protein PhoH
APT61_RS16340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT61_RS16360	COG0765	amino acid transport
APT61_RS16365	COG0765	amino acid transport
APT61_RS16370	COG1126	abc transporter atp-binding protein
APT61_RS16380	COG2888	peptidyl-tyrosine sulfation
APT61_RS16395	COG1466	dna polymerase III delta subunit
APT61_RS16405	COG0799	negative regulation of ribosome biogenesis
APT61_RS16415	COG0768	penicillin binding
APT61_RS16420	COG0772	Belongs to the SEDS family
APT61_RS16425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT61_RS16430	COG1686	Belongs to the peptidase S11 family
APT61_RS16440	COG0321	lipoyl(octanoyl) transferase activity
APT61_RS16445	COG0583	DNA-binding transcription factor activity
APT61_RS16455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT61_RS16460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT61_RS16465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT61_RS16480	COG3069	C4-dicarboxylate transmembrane transporter activity
APT61_RS16485	COG3719	Belongs to the RNase T2 family
APT61_RS16490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT61_RS16495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT61_RS16500	COG1063	alcohol dehydrogenase
APT61_RS16515	COG0450	alkyl hydroperoxide reductase
APT61_RS16520	COG0583	DNA-binding transcription factor activity
APT61_RS16525	COG0436	Aminotransferase
APT61_RS16530	COG0235	Class ii aldolase
APT61_RS16535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APT61_RS16540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APT61_RS16545	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APT61_RS16550	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
APT61_RS16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS16570	COG1129	ABC transporter
APT61_RS16575	COG0371	Dehydrogenase
APT61_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS16585	COG2879	small protein
APT61_RS16590	COG1966	Carbon starvation protein
APT61_RS16595	COG3366	ferrous iron transmembrane transporter activity
APT61_RS16600	COG0700	Nucleoside recognition
APT61_RS16610	COG2050	protein possibly involved in aromatic compounds catabolism
APT61_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
APT61_RS16620	COG1535	isochorismatase
APT61_RS16620	COG3433	isochorismatase activity
APT61_RS16625	COG1021	2,3-dihydroxybenzoate-AMP ligase
APT61_RS16630	COG1169	isochorismate synthase
APT61_RS16635	COG4592	Periplasmic binding protein
APT61_RS16645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS16650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS16655	COG1120	ATPase activity
APT61_RS16660	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
APT61_RS16660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT61_RS16665	COG3251	PFAM MbtH domain protein
APT61_RS16670	COG2382	esterase
APT61_RS16675	COG4771	TonB-dependent receptor
APT61_RS16685	COG1879	ABC-type sugar transport system periplasmic component
APT61_RS16695	COG1129	ABC transporter
APT61_RS16700	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS16705	COG2390	Transcriptional regulator
APT61_RS16710	COG3959	Transketolase, thiamine diphosphate binding domain
APT61_RS16715	COG3958	Transketolase
APT61_RS16725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT61_RS16750	COG1203	CRISPR-associated helicase, Cas3
APT61_RS16770	COG0601	transmembrane transport
APT61_RS16775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS16780	COG0444	Belongs to the ABC transporter superfamily
APT61_RS16785	COG4608	Belongs to the ABC transporter superfamily
APT61_RS16790	COG1278	Cold shock
APT61_RS16800	COG0456	acetyltransferase
APT61_RS16805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APT61_RS16835	COG4774	siderophore transport
APT61_RS16855	COG2315	Protein conserved in bacteria
APT61_RS16860	COG0778	Nitroreductase
APT61_RS16880	COG0477	Major facilitator Superfamily
APT61_RS16885	COG0668	transmembrane transport
APT61_RS16890	COG1609	Transcriptional regulator
APT61_RS16905	COG2211	Major facilitator Superfamily
APT61_RS16915	COG1396	sequence-specific DNA binding
APT61_RS16920	COG1113	amino acid transport
APT61_RS16955	COG2501	S4 domain
APT61_RS16960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS16960	COG1263	PTS System
APT61_RS16960	COG2190	(PTS) system
APT61_RS16965	COG1609	Transcriptional regulator
APT61_RS16970	COG1988	membrane-bound metal-dependent
APT61_RS16980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT61_RS16985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT61_RS17000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT61_RS17005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APT61_RS17020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APT61_RS17025	COG4181	ATPase activity
APT61_RS17030	COG2755	lipolytic protein G-D-S-L family
APT61_RS17035	COG0300	oxidoreductase activity
APT61_RS17040	COG3118	belongs to the thioredoxin family
APT61_RS17045	COG0330	HflC and HflK could
APT61_RS17050	COG1585	Membrane protein implicated in regulation of membrane protease activity
APT61_RS17075	COG3735	TraB family
APT61_RS17080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT61_RS17090	COG2223	nitrite transmembrane transporter activity
APT61_RS17095	COG4651	solute:proton antiporter activity
APT61_RS17095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT61_RS17100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT61_RS17105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT61_RS17110	COG0563	adenylate kinase activity
APT61_RS17115	COG0326	Molecular chaperone. Has ATPase activity
APT61_RS17125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APT61_RS17135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT61_RS17140	COG2832	Protein of unknown function (DUF454)
APT61_RS17145	COG3923	Primosomal replication protein n
APT61_RS17150	COG3264	Mechanosensitive ion channel
APT61_RS17150	COG1196	nuclear chromosome segregation
APT61_RS17155	COG1309	transcriptional regulator
APT61_RS17160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT61_RS17165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT61_RS17185	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APT61_RS17190	COG5507	3-demethylubiquinone-9 3-methyltransferase
APT61_RS17195	COG3250	beta-galactosidase activity
APT61_RS17200	COG1609	Transcriptional regulator
APT61_RS17205	COG2364	Membrane
APT61_RS17210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS17230	COG3695	enzyme binding
APT61_RS17235	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APT61_RS17240	COG1946	Acyl-CoA thioesterase
APT61_RS17245	COG0004	ammonium transporteR
APT61_RS17250	COG0347	Belongs to the P(II) protein family
APT61_RS17255	COG1132	(ABC) transporter
APT61_RS17260	COG1132	(ABC) transporter
APT61_RS17265	COG1522	sequence-specific DNA binding
APT61_RS17275	COG0561	phosphatase activity
APT61_RS17280	COG4533	DNA binding
APT61_RS17290	COG0824	Thioesterase
APT61_RS17295	COG1555	photosystem II stabilization
APT61_RS17300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT61_RS17305	COG0776	regulation of translation
APT61_RS17310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APT61_RS17330	COG0271	Belongs to the BolA IbaG family
APT61_RS17335	COG3056	Lipoprotein
APT61_RS17340	COG2223	nitrite transmembrane transporter activity
APT61_RS17345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APT61_RS17350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT61_RS17355	COG1845	cytochrome c oxidase, subunit III
APT61_RS17360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT61_RS17365	COG0109	protoheme IX farnesyltransferase activity
APT61_RS17370	COG2814	Major facilitator Superfamily
APT61_RS17385	COG0693	protein deglycase activity
APT61_RS17400	COG0142	geranyltranstransferase activity
APT61_RS17405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APT61_RS17410	COG0667	Aldo Keto reductase
APT61_RS17420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT61_RS17425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APT61_RS17430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT61_RS17430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT61_RS17440	COG4238	major outer membrane lipoprotein
APT61_RS17445	COG3248	Nucleoside-binding outer membrane protein
APT61_RS17460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT61_RS17465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT61_RS17470	COG1862	Preprotein translocase
APT61_RS17480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT61_RS17485	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
APT61_RS17490	COG0450	alkyl hydroperoxide reductase
APT61_RS17495	COG0366	Alpha amylase catalytic
APT61_RS17510	COG5002	protein histidine kinase activity
APT61_RS17520	COG0420	3'-5' exonuclease activity
APT61_RS17525	COG0419	ATPase involved in DNA repair
APT61_RS17530	COG1940	carbohydrate kinase activity
APT61_RS17540	COG3123	guanosine phosphorylase activity
APT61_RS17545	COG4126	flavin adenine dinucleotide binding
APT61_RS17555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT61_RS17560	COG1671	Belongs to the UPF0178 family
APT61_RS17565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APT61_RS17570	COG3706	GGDEF domain
APT61_RS17620	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APT61_RS17625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APT61_RS17640	COG0113	porphobilinogen synthase activity
APT61_RS17650	COG2175	clavaminate synthase activity
APT61_RS17655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT61_RS17660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT61_RS17665	COG4521	taurine ABC transporter
APT61_RS17680	COG2271	Major facilitator Superfamily
APT61_RS17685	COG1840	ABC-type Fe3 transport system, periplasmic component
APT61_RS17695	COG3842	ATPase activity
APT61_RS17700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT61_RS17725	COG2211	Major facilitator Superfamily
APT61_RS17740	COG0667	Aldo Keto reductase
APT61_RS17750	COG1064	alcohol dehydrogenase
APT61_RS17770	COG2040	homocysteine
APT61_RS17775	COG0833	amino acid
APT61_RS17780	COG0628	permease
APT61_RS17785	COG3706	GGDEF domain
APT61_RS17805	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS17810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT61_RS17815	COG0697	spore germination
APT61_RS17820	COG2271	Major facilitator Superfamily
APT61_RS17835	COG0163	prenyltransferase activity
APT61_RS17845	COG2080	2 iron, 2 sulfur cluster binding
APT61_RS17850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APT61_RS17855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT61_RS17860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APT61_RS17865	COG0583	DNA-binding transcription factor activity
APT61_RS17910	COG5001	Diguanylate cyclase
APT61_RS17915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT61_RS17920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT61_RS17925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT61_RS17935	COG1073	alpha beta
APT61_RS17945	COG2195	Cleaves the N-terminal amino acid of tripeptides
APT61_RS17950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT61_RS17960	COG2991	Protein conserved in bacteria
APT61_RS17975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APT61_RS17980	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APT61_RS17995	COG3034	peptidoglycan biosynthetic process
APT61_RS18000	COG0121	glutamine amidotransferase
APT61_RS18010	COG1960	acyl-CoA dehydrogenase activity
APT61_RS18015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT61_RS18025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT61_RS18035	COG2226	methyltransferase
APT61_RS18040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT61_RS18045	COG0741	lytic transglycosylase activity
APT61_RS18045	COG1388	LysM domain
APT61_RS18050	COG2226	methyltransferase
APT61_RS18055	COG3021	interspecies interaction between organisms
APT61_RS18060	COG2814	Major facilitator Superfamily
APT61_RS18065	COG0583	DNA-binding transcription factor activity
APT61_RS18070	COG0656	L-ascorbic acid biosynthetic process
APT61_RS18105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APT61_RS18115	COG2011	ABC-type metal ion transport system permease component
APT61_RS18120	COG1464	Belongs to the NlpA lipoprotein family
APT61_RS18130	COG1720	tRNA m6t6A37 methyltransferase activity
APT61_RS18140	COG3015	lipoprotein NlpE involved in copper resistance
APT61_RS18145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT61_RS18150	COG4681	YaeQ
APT61_RS18160	COG4568	rho-dependent transcription termination
APT61_RS18165	COG0037	tRNA processing
APT61_RS18170	COG0346	lactoylglutathione lyase activity
APT61_RS18175	COG1982	Orn Lys Arg decarboxylase major
APT61_RS18180	COG0825	malonyl-CoA metabolic process
APT61_RS18190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT61_RS18195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT61_RS18205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT61_RS18210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT61_RS18215	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APT61_RS18220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT61_RS18230	COG0575	Belongs to the CDS family
APT61_RS18240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APT61_RS18245	COG0233	cytoplasmic translational termination
APT61_RS18255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT61_RS18285	COG3835	regulator
APT61_RS18295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APT61_RS18310	COG2860	membrane
APT61_RS18315	COG0316	Belongs to the HesB IscA family
APT61_RS18325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APT61_RS18330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS18335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT61_RS18340	COG1120	ATPase activity
APT61_RS18345	COG4774	siderophore transport
APT61_RS18350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT61_RS18355	COG1643	Atp-dependent helicase
APT61_RS18360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APT61_RS18365	COG1489	DNA binding
APT61_RS18380	COG0617	tRNA 3'-terminal CCA addition
APT61_RS18385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APT61_RS18390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APT61_RS18395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APT61_RS18400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APT61_RS18405	COG0726	polysaccharide deacetylase
APT61_RS18410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS18415	COG0842	Transport permease protein
APT61_RS18420	COG1131	(ABC) transporter
APT61_RS18425	COG0288	reversible hydration of carbon dioxide
APT61_RS18430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APT61_RS18435	COG4993	Dehydrogenase
APT61_RS18455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APT61_RS18470	COG3064	Membrane
APT61_RS18480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT61_RS18485	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT61_RS18490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APT61_RS18505	COG2211	Major facilitator Superfamily
APT61_RS18510	COG3940	Belongs to the glycosyl hydrolase 43 family
APT61_RS18515	COG3725	Membrane protein required for beta-lactamase induction
APT61_RS18520	COG3023	N-Acetylmuramoyl-L-alanine amidase
APT61_RS18530	COG4969	Belongs to the N-Me-Phe pilin family
APT61_RS18535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APT61_RS18540	COG1459	type II secretion system
APT61_RS18545	COG0516	GMP reductase activity
APT61_RS18555	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
APT61_RS18565	COG0494	nUDIX hydrolase
APT61_RS18570	COG0653	protein targeting
APT61_RS18580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APT61_RS18585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APT61_RS18590	COG0849	cell division
APT61_RS18600	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT61_RS18615	COG0772	Belongs to the SEDS family
APT61_RS18630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APT61_RS18635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT61_RS18640	COG0768	penicillin binding
APT61_RS18655	COG2001	Belongs to the MraZ family
APT61_RS18670	COG0028	Belongs to the TPP enzyme family
APT61_RS18680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT61_RS18735	COG0583	DNA-binding transcription factor activity
APT61_RS18740	COG0667	Aldo Keto reductase
APT61_RS18770	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS18775	COG1846	Transcriptional regulator
APT61_RS18780	COG0657	acetylesterase activity
APT61_RS18785	COG2015	COG2015, Alkyl sulfatase and related hydrolases
APT61_RS18790	COG2801	Transposase and inactivated derivatives
APT61_RS18795	COG2963	transposase activity
APT61_RS18800	COG2814	Major facilitator Superfamily
APT61_RS18815	COG1178	ABC-type Fe3 transport system permease component
APT61_RS18825	COG0586	Pfam SNARE associated Golgi protein
APT61_RS18830	COG4977	sequence-specific DNA binding
APT61_RS18835	COG1069	ribulokinase activity
APT61_RS18840	COG2160	L-arabinose isomerase activity
APT61_RS18845	COG0235	Class ii aldolase
APT61_RS18850	COG0417	DNA replication proofreading
APT61_RS18855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APT61_RS18860	COG0564	pseudouridine synthase activity
APT61_RS18865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APT61_RS18870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APT61_RS18875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT61_RS18880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT61_RS18890	COG2967	ApaG domain
APT61_RS18895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT61_RS18905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT61_RS18905	COG0475	glutathione-regulated potassium exporter activity
APT61_RS18910	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT61_RS18935	COG0505	Belongs to the CarA family
APT61_RS18945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT61_RS18955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APT61_RS18960	COG1047	Peptidyl-prolyl cis-trans
APT61_RS18965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT61_RS18975	COG0196	riboflavin kinase activity
APT61_RS18980	COG0268	Binds directly to 16S ribosomal RNA
APT61_RS18985	COG0583	DNA-binding transcription factor activity
APT61_RS18990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT61_RS19000	COG0443	Heat shock 70 kDa protein
APT61_RS19005	COG1584	GPR1 FUN34 yaaH family protein
APT61_RS19010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT61_RS19015	COG1120	ATPase activity
APT61_RS19025	COG0477	Major facilitator Superfamily
APT61_RS19030	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT61_RS19040	COG1115	amino acid carrier protein
APT61_RS19045	COG3022	response to hydroperoxide
APT61_RS19055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APT61_RS19065	COG0460	homoserine dehydrogenase
APT61_RS19065	COG0527	aspartate kinase activity
APT61_RS19070	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APT61_RS19075	COG0745	RESPONSE REGULATOR receiver
APT61_RS19080	COG3045	CreA protein
APT61_RS19085	COG2207	Transcriptional regulator
APT61_RS19085	COG3708	Transcriptional regulator
APT61_RS19095	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
APT61_RS19100	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
APT61_RS19105	COG0741	lytic transglycosylase activity
APT61_RS19110	COG0488	(ABC) transporter
APT61_RS19120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APT61_RS19125	COG0560	Phosphoserine phosphatase
APT61_RS19130	COG3726	membrane protein affecting hemolysin expression
APT61_RS19160	COG1328	CTP reductase activity
APT61_RS19165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT61_RS19170	COG0084	hydrolase, TatD family'
APT61_RS19175	COG4667	esterase of the alpha-beta hydrolase superfamily
APT61_RS19180	COG2823	Periplasmic or secreted lipoprotein
APT61_RS19185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT61_RS19190	COG1011	Hydrolase
APT61_RS19195	COG0456	acetyltransferase
APT61_RS19200	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
APT61_RS19205	COG2813	Specifically methylates the guanine in position
APT61_RS19230	COG4114	ferric iron reductase
APT61_RS19235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT61_RS19240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT61_RS19245	COG2197	response regulator
APT61_RS19250	COG2197	response regulator
APT61_RS19255	COG2966	Psort location CytoplasmicMembrane, score
APT61_RS19260	COG3610	response to peptide
APT61_RS19265	COG1309	transcriptional regulator
APT61_RS19270	COG1764	response to oxidative stress
APT61_RS19280	COG1484	DNA-dependent DNA replication
APT61_RS19295	COG0840	transmembrane signaling receptor activity
APT61_RS19300	COG1846	Transcriptional regulator
APT61_RS19310	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS19315	COG3384	dioxygenase
APT61_RS19325	COG3971	2-oxopent-4-enoate hydratase activity
APT61_RS19365	COG2368	4-hydroxyphenylacetate
APT61_RS19370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT61_RS19400	COG0438	transferase activity, transferring glycosyl groups
APT61_RS19400	COG1216	Glycosyl transferase, family 2
APT61_RS19430	COG0438	transferase activity, transferring glycosyl groups
APT61_RS19430	COG1216	Glycosyl transferase, family 2
APT61_RS19445	COG1091	dTDP-4-dehydrorhamnose reductase activity
APT61_RS19490	COG1966	Carbon starvation protein
APT61_RS19495	COG2879	small protein
APT61_RS19500	COG0523	cobalamin synthesis protein
APT61_RS19515	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS19540	COG2733	membrane
APT61_RS19550	COG1566	PFAM secretion protein HlyD family protein
APT61_RS19575	COG0640	Transcriptional regulator
APT61_RS19595	COG0583	DNA-binding transcription factor activity
APT61_RS19600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT61_RS19615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT61_RS19640	COG2850	peptidyl-arginine hydroxylation
APT61_RS19650	COG1349	DNA-binding transcription factor activity
APT61_RS19655	COG2223	nitrite transmembrane transporter activity
APT61_RS19660	COG0346	lactoylglutathione lyase activity
APT61_RS19665	COG4566	intracellular signal transduction
APT61_RS19670	COG4191	Histidine kinase
APT61_RS19690	COG1335	isochorismatase
APT61_RS19695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
APT61_RS19700	COG2259	Doxx family
APT61_RS19735	COG1401	restriction endodeoxyribonuclease activity
APT61_RS19745	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS19750	COG0531	amino acid
APT61_RS19760	COG0579	oxidoreductase
APT61_RS19765	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS19770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT61_RS19775	COG1802	Transcriptional regulator
APT61_RS19800	COG0863	Belongs to the N(4) N(6)-methyltransferase family
APT61_RS19835	COG0582	viral genome integration into host DNA
APT61_RS19860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT61_RS19870	COG1414	Transcriptional regulator
APT61_RS19875	COG3507	Belongs to the glycosyl hydrolase 43 family
APT61_RS19880	COG2211	Major facilitator Superfamily
APT61_RS19885	COG0129	dihydroxy-acid dehydratase activity
APT61_RS19890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT61_RS19895	COG2731	YhcH YjgK YiaL family protein
APT61_RS19905	COG0540	Belongs to the ATCase OTCase family
APT61_RS19920	COG3397	chitin binding
APT61_RS19925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APT61_RS19930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT61_RS19935	COG1609	Transcriptional regulator
APT61_RS19940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT61_RS19940	COG1263	PTS System
APT61_RS19945	COG0366	Alpha amylase catalytic
APT61_RS19955	COG0602	queuosine metabolic process
APT61_RS19960	COG3711	transcriptional antiterminator
APT61_RS19960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS19980	COG3964	amidohydrolase
APT61_RS20020	COG0312	modulator of DNA gyrase
APT61_RS20025	COG3028	Belongs to the UPF0307 family
APT61_RS20030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT61_RS20035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APT61_RS20050	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS20055	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS20060	COG1129	ABC transporter
APT61_RS20065	COG1879	ABC-type sugar transport system periplasmic component
APT61_RS20070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APT61_RS20075	COG0840	transmembrane signaling receptor activity
APT61_RS20080	COG2105	PFAM AIG2 family protein
APT61_RS20085	COG2911	Protein conserved in bacteria
APT61_RS20090	COG0729	surface antigen
APT61_RS20100	COG1253	flavin adenine dinucleotide binding
APT61_RS20110	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APT61_RS20115	COG1218	3'(2'),5'-bisphosphate nucleotidase
APT61_RS20125	COG0431	NADPH-dependent FMN reductase
APT61_RS20130	COG0640	Transcriptional regulator
APT61_RS20165	COG0697	spore germination
APT61_RS20170	COG1733	regulation of RNA biosynthetic process
APT61_RS20175	COG0702	epimerase
APT61_RS20180	COG0840	transmembrane signaling receptor activity
APT61_RS20185	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APT61_RS20190	COG1113	amino acid transport
APT61_RS20195	COG0545	Peptidyl-prolyl cis-trans isomerase
APT61_RS20200	COG3061	Opacity-associated protein A
APT61_RS20210	COG0359	binds to the 23S rRNA
APT61_RS20215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT61_RS20220	COG2965	DNA replication, synthesis of RNA primer
APT61_RS20225	COG0360	Binds together with S18 to 16S ribosomal RNA
APT61_RS20275	COG1073	alpha beta
APT61_RS20280	COG3650	response to hydrogen peroxide
APT61_RS20295	COG1960	acyl-CoA dehydrogenase activity
APT61_RS20300	COG0477	Major facilitator Superfamily
APT61_RS20305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT61_RS20310	COG0557	exoribonuclease II activity
APT61_RS20315	COG1959	2 iron, 2 sulfur cluster binding
APT61_RS20325	COG0330	HflC and HflK could
APT61_RS20330	COG0330	HflC and HflK could
APT61_RS20335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT61_RS20340	COG1923	regulation of RNA biosynthetic process
APT61_RS20345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT61_RS20350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT61_RS20360	COG0802	atpase or kinase
APT61_RS20365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT61_RS20365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APT61_RS20370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APT61_RS20390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APT61_RS20405	COG3264	Mechanosensitive ion channel
APT61_RS20405	COG1511	domain protein
APT61_RS20420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APT61_RS20425	COG1053	succinate dehydrogenase
APT61_RS20430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT61_RS20435	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APT61_RS20460	COG5510	response to toxic substance
APT61_RS20470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT61_RS20475	COG1509	lysine 2,3-aminomutase activity
APT61_RS20485	COG0459	protein refolding
APT61_RS20495	COG0531	amino acid
APT61_RS20500	COG3030	protein affecting phage T7 exclusion by the F plasmid
APT61_RS20505	COG1027	Aspartate ammonia-lyase
APT61_RS20510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APT61_RS20525	COG1309	transcriptional regulator
APT61_RS20570	COG0297	glycogen (starch) synthase activity
APT61_RS20570	COG0438	transferase activity, transferring glycosyl groups
APT61_RS20600	COG1596	polysaccharide export
APT61_RS20610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT61_RS20630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APT61_RS20635	COG2824	Alkylphosphonate utilization operon protein PhnA
APT61_RS20640	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APT61_RS20650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APT61_RS20655	COG3639	organic phosphonate transmembrane transporter activity
APT61_RS20660	COG2188	Transcriptional regulator
APT61_RS20665	COG3624	Phosphonate C-P lyase system protein PhnG
APT61_RS20670	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APT61_RS20675	COG3626	phosphonate metabolism
APT61_RS20680	COG3627	carbon phosphorus lyase activity
APT61_RS20685	COG4107	phosphonate C-P lyase system protein PhnK
APT61_RS20690	COG4778	phosphonate C-P lyase system protein PhnL
APT61_RS20695	COG3454	Phosphonate metabolism
APT61_RS20700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APT61_RS20705	COG0456	acetyltransferase
APT61_RS20710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APT61_RS20725	COG1129	ABC transporter
APT61_RS20730	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT61_RS20735	COG1879	ABC-type sugar transport system periplasmic component
APT61_RS20745	COG0191	fructose-bisphosphate aldolase activity
APT61_RS20760	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS20765	COG3383	formate dehydrogenase (NAD+) activity
APT61_RS20770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APT61_RS20775	COG1301	dicarboxylic acid transport
APT61_RS20785	COG3162	membrane
APT61_RS20790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT61_RS20800	COG0673	inositol 2-dehydrogenase activity
APT61_RS20810	COG1346	cytolysis
APT61_RS20820	COG0583	DNA-binding transcription factor activity
APT61_RS20825	COG0025	NhaP-type Na H and K H
APT61_RS20830	COG2252	PERMEase
APT61_RS20835	COG0625	glutathione transferase activity
APT61_RS20840	COG0789	Transcriptional regulator
APT61_RS20850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APT61_RS20865	COG0629	single-stranded DNA binding
APT61_RS20870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APT61_RS20875	COG2315	Protein conserved in bacteria
APT61_RS20880	COG0432	Pfam Uncharacterised protein family UPF0047
APT61_RS20885	COG3700	Belongs to the class B bacterial acid phosphatase family
APT61_RS20890	COG1448	Aminotransferase
APT61_RS20900	COG0305	Participates in initiation and elongation during chromosome replication
APT61_RS20915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT61_RS20930	COG0735	belongs to the Fur family
APT61_RS20940	COG0534	Mate efflux family protein
APT61_RS20945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT61_RS20950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APT61_RS20955	COG2937	Belongs to the GPAT DAPAT family
APT61_RS20965	COG3161	chorismate lyase activity
APT61_RS20975	COG4580	involved in the transport of maltose and maltodextrins
APT61_RS21000	COG3223	Belongs to the PsiE family
APT61_RS21005	COG0166	Belongs to the GPI family
APT61_RS21010	COG0527	aspartate kinase activity
APT61_RS21015	COG3541	Predicted nucleotidyltransferase
APT61_RS21020	COG1690	Belongs to the RtcB family
APT61_RS21025	COG4650	regulator
APT61_RS21040	COG1187	pseudouridine synthase activity
APT61_RS21075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APT61_RS21110	COG0151	Belongs to the GarS family
APT61_RS21135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APT61_RS21145	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
APT61_RS21160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT61_RS21165	COG2104	thiamine diphosphate biosynthetic process
APT61_RS21170	COG2022	thiamine diphosphate biosynthetic process
APT61_RS21175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APT61_RS21185	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT61_RS21220	COG0250	Participates in transcription elongation, termination and antitermination
APT61_RS21255	COG1072	(Pantothenic acid kinase))
APT61_RS21260	COG4608	Belongs to the ABC transporter superfamily
APT61_RS21265	COG0444	Belongs to the ABC transporter superfamily
APT61_RS21270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT61_RS21275	COG0601	transmembrane transport
APT61_RS21280	COG0747	negative chemotaxis
APT61_RS21300	COG2194	sulfuric ester hydrolase activity
APT61_RS21305	COG2223	nitrite transmembrane transporter activity
APT61_RS21310	COG5571	outer membrane autotransporter
APT61_RS21315	COG2818	Glycosylase
APT61_RS21320	COG0456	acetyltransferase
APT61_RS21325	COG0243	molybdopterin cofactor binding
APT61_RS21330	COG2885	chlorophyll binding
APT61_RS21335	COG1609	Transcriptional regulator
APT61_RS21345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT61_RS21360	COG1278	Cold shock
APT61_RS21370	COG2944	sequence-specific DNA binding
APT61_RS21375	COG0488	(ABC) transporter
APT61_RS21380	COG0751	glycine-tRNA ligase activity
APT61_RS21385	COG0752	glycyl-tRNA synthetase alpha subunit
APT61_RS21395	COG3274	enterobacterial common antigen metabolic process
APT61_RS21400	COG1070	Carbohydrate kinase
APT61_RS21405	COG2115	Belongs to the xylose isomerase family
APT61_RS21410	COG4213	ABC transporter substrate-binding protein
APT61_RS21420	COG4214	carbohydrate transport
APT61_RS21425	COG1609	Transcriptional regulator
APT61_RS21425	COG2207	Transcriptional regulator
APT61_RS21430	COG2992	FlgJ-related protein
APT61_RS21435	COG0366	Alpha amylase catalytic
APT61_RS21440	COG3977	Valine--pyruvate aminotransferase
APT61_RS21445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT61_RS21455	COG2211	Major facilitator Superfamily
APT61_RS21465	COG3713	MltA-interacting MipA family protein
APT61_RS21470	COG0583	DNA-binding transcription factor activity
APT61_RS21475	COG1012	belongs to the aldehyde dehydrogenase family
APT61_RS21480	COG1940	carbohydrate kinase activity
APT61_RS21485	COG3276	selenocysteine insertion sequence binding
APT61_RS21495	COG0625	glutathione transferase activity
APT61_RS21500	COG1566	PFAM secretion protein HlyD family protein
APT61_RS21510	COG2213	PTS system mannitol-specific
APT61_RS21510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT61_RS21520	COG3722	fumarate hydratase activity
APT61_RS21535	COG2186	Transcriptional regulator
APT61_RS21540	COG1304	FMN binding
APT61_RS21545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APT61_RS21555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT61_RS21560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APT61_RS21565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT61_RS21570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT61_RS21575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APT61_RS21580	COG4942	peptidase
APT61_RS21585	COG2861	carbohydrate metabolic process
APT61_RS21595	COG1063	alcohol dehydrogenase
APT61_RS21610	COG0859	PFAM glycosyl transferase family 9
APT61_RS21620	COG0859	PFAM glycosyl transferase family 9
APT61_RS21625	COG0438	transferase activity, transferring glycosyl groups
APT61_RS21640	COG1216	Glycosyl transferase, family 2
APT61_RS21655	COG1519	Transferase
APT61_RS21665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT61_RS21670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT61_RS21675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT61_RS21680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT61_RS21685	COG2003	Belongs to the UPF0758 family
APT61_RS21690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT61_RS21695	COG0756	dUTP diphosphatase activity
APT61_RS21715	COG1561	YicC-like family, N-terminal region
APT61_RS21720	COG2860	membrane
APT61_RS21725	COG2194	sulfuric ester hydrolase activity
APT61_RS21730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT61_RS21745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT61_RS21750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT61_RS21755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT61_RS21760	COG0786	glutamate:sodium symporter activity
APT61_RS21765	COG2233	PERMEase
APT61_RS21770	COG2982	Protein involved in outer membrane biogenesis
APT61_RS21775	COG1501	Belongs to the glycosyl hydrolase 31 family
APT61_RS21780	COG2211	Major facilitator Superfamily
APT61_RS21795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT61_RS21815	COG0519	Catalyzes the synthesis of GMP from XMP
APT61_RS21835	COG0789	Transcriptional regulator
APT61_RS21845	COG3272	Protein of unknown function (DUF1722)
APT61_RS21850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT61_RS21855	COG1464	Belongs to the NlpA lipoprotein family
APT61_RS21865	COG1309	transcriptional regulator
APT61_RS21880	COG1609	Transcriptional regulator
APT61_RS21890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT61_RS21895	COG2723	6-phospho-beta-galactosidase activity
APT61_RS21900	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT61_RS21905	COG4580	involved in the transport of maltose and maltodextrins
APT61_RS21910	COG0697	spore germination
APT61_RS21925	COG0596	Alpha beta hydrolase
APT61_RS21935	COG0738	Major facilitator superfamily
APT61_RS21945	COG1349	DNA-binding transcription factor activity
APT61_RS21950	COG0440	acetolactate synthase activity
APT61_RS21955	COG0028	Belongs to the TPP enzyme family
APT61_RS21985	COG2814	Major facilitator Superfamily
APT61_RS21995	COG0641	radical SAM
APT61_RS22005	COG2149	membrane
APT61_RS22010	COG2985	domain, Protein
APT61_RS22015	COG0071	Belongs to the small heat shock protein (HSP20) family
APT61_RS22025	COG5645	(Lipo)protein
APT61_RS22030	COG0823	Involved in the tonB-independent uptake of proteins
APT61_RS22035	COG0561	phosphatase activity
APT61_RS22040	COG2271	Major facilitator Superfamily
APT61_RS22045	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT61_RS22050	COG1063	alcohol dehydrogenase
APT61_RS22055	COG0246	Mannitol dehydrogenase
APT61_RS22060	COG4948	Mandelate Racemase Muconate Lactonizing
APT61_RS22065	COG2186	Transcriptional regulator
APT61_RS22075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT61_RS22095	COG0706	membrane insertase activity
APT61_RS22110	COG0814	amino acid
APT61_RS22125	COG2091	lysine biosynthetic process via aminoadipic acid
APT61_RS22130	COG0431	NADPH-dependent FMN reductase
APT61_RS22135	COG2252	PERMEase
APT61_RS22140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT61_RS22145	COG2382	esterase
APT61_RS22155	COG0704	Plays a role in the regulation of phosphate uptake
APT61_RS22165	COG0581	inorganic phosphate transmembrane transporter activity
APT61_RS22170	COG0573	inorganic phosphate transmembrane transporter activity
APT61_RS22175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT61_RS22195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APT61_RS22200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APT61_RS22205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APT61_RS22210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APT61_RS22215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation