locus-tag	class	description
HCN54_RS00010	ENOG4105CTU	Proline racemase
HCN54_RS00020	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HCN54_RS00045	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HCN54_RS00065	ENOG4105CPC	Aldo Keto reductase
HCN54_RS00085	ENOG4105DY9	regulatoR
HCN54_RS00095	ENOG4105CWX	Alpha-1,2-mannosidase
HCN54_RS00105	ENOG4105CKB	glycosidase
HCN54_RS00110	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
HCN54_RS00125	ENOG4105E2D	ec 3.2.1.52
HCN54_RS00135	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HCN54_RS00145	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HCN54_RS00175	ENOG4105E98	transcriptional regulator DeoR family
HCN54_RS00180	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HCN54_RS00185	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HCN54_RS00190	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HCN54_RS00210	ENOG4105DY8	decarboxylase
HCN54_RS00215	ENOG4105D7K	pfkb domain protein
HCN54_RS00225	ENOG4108HKT	sucrose-6-phosphate hydrolase
HCN54_RS00235	ENOG4107URF	beta-phospho-glucomutase
HCN54_RS00250	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HCN54_RS00290	ENOG4105CBX	hi0933 family
HCN54_RS00295	ENOG4105KAV	tspo and mbr like protein
HCN54_RS00320	ENOG4105FE9	pseudouridine synthase
HCN54_RS00335	ENOG4105E0R	Deoxyhypusine synthase
HCN54_RS00340	ENOG4105E2D	ec 3.2.1.52
HCN54_RS00345	ENOG4105CKK	Glycosyl transferase, family 2
HCN54_RS00375	ENOG4105CND	Glycosyl transferase, family 2
HCN54_RS00380	ENOG4105C3Q	Glycosyl transferase, family 2
HCN54_RS00405	ENOG4105VPI	YqaE family transport protein
HCN54_RS00420	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HCN54_RS00445	ENOG4108V0P	LemA family
HCN54_RS00460	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HCN54_RS00485	ENOG4105BZU	Histidine kinase
HCN54_RS00495	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN54_RS00535	ENOG4105K6H	D-cysteine desulfhydrase
HCN54_RS00540	ENOG41068JE	domain protein
HCN54_RS00545	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HCN54_RS00555	ENOG4105CRK	lysyL-tRNA synthetase
HCN54_RS00565	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HCN54_RS00580	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HCN54_RS00585	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS00655	ENOG4105C0B	DNA polymerase III (alpha subunit)
HCN54_RS00660	ENOG4107VJY	DNA polymerase
HCN54_RS00665	ENOG4108NEV	two component transcriptional regulator, LytTR family
HCN54_RS00670	ENOG4108HRK	Histidine kinase
HCN54_RS00675	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS00680	ENOG4105C19	ABC transporter
HCN54_RS00685	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HCN54_RS00705	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HCN54_RS00730	ENOG4105C37	(CBS) domain
HCN54_RS00735	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HCN54_RS00755	ENOG4105C5Z	peptidase
HCN54_RS00760	ENOG4105DUX	Transporter
HCN54_RS00765	ENOG4105DUX	Transporter
HCN54_RS00775	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HCN54_RS00780	ENOG4107TT5	NLP P60 protein
HCN54_RS00790	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HCN54_RS00795	ENOG4105CN1	protease
HCN54_RS00800	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HCN54_RS00810	ENOG4105CNI	cell division protein FtsW
HCN54_RS00815	ENOG4105CJN	penicillin-binding protein
HCN54_RS00830	ENOG4105DFF	Rod shape-determining protein mreb
HCN54_RS00835	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HCN54_RS00840	ENOG4107RBB	ABC transporter, permease
HCN54_RS00865	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HCN54_RS00870	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HCN54_RS00890	ENOG4107SM7	Transcriptional regulator
HCN54_RS00895	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HCN54_RS00900	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HCN54_RS00910	ENOG4105E6M	Sulphatase-modifying factor protein
HCN54_RS00930	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HCN54_RS00940	ENOG4105C5H	ABC transporter
HCN54_RS00985	ENOG4108IJF	Heavy metal efflux pump, CzcA
HCN54_RS01000	ENOG4105E3B	Multicopper oxidase
HCN54_RS01035	ENOG4105CBC	glutamate synthase
HCN54_RS01050	ENOG4108M4U	conserved membrane protein
HCN54_RS01060	ENOG4105C59	p-type ATPase
HCN54_RS01080	ENOG4105FA0	parb-like partition protein
HCN54_RS01120	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HCN54_RS01125	ENOG4107XMK	single-stranded DNA-binding protein
HCN54_RS01130	ENOG4105W5Q	DNA repair protein (RadC
HCN54_RS01190	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HCN54_RS01195	ENOG4107QN2	dihydrolipoyl dehydrogenase
HCN54_RS01210	ENOG4108302	MgtC SapB transporter
HCN54_RS01215	ENOG4105FFC	UPF0187 protein
HCN54_RS01245	ENOG4108YZA	Nitrogen regulatory protein pii
HCN54_RS01280	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HCN54_RS01285	ENOG4105E6M	Sulphatase-modifying factor protein
HCN54_RS01300	ENOG4105KG3	cytidine deaminase
HCN54_RS01305	ENOG4108JYK	Dehydrogenase
HCN54_RS01310	ENOG4105C7S	Dehydrogenase
HCN54_RS01315	ENOG4105IIU	Aminopeptidase
HCN54_RS01340	ENOG4105DHJ	ABC, transporter
HCN54_RS01375	ENOG4105K64	Glycosyl transferase, family 2
HCN54_RS01395	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN54_RS01415	ENOG4105DGW	oligopeptidase A
HCN54_RS01420	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HCN54_RS01425	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HCN54_RS01430	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HCN54_RS01435	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN54_RS01450	ENOG4105DFU	Cell wall formation (By similarity)
HCN54_RS01465	ENOG4105W5Q	DNA repair protein (RadC
HCN54_RS01495	ENOG4105D1H	recombination factor protein RarA
HCN54_RS01515	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS01540	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HCN54_RS01545	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HCN54_RS01550	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HCN54_RS01555	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HCN54_RS01560	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HCN54_RS01565	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HCN54_RS01570	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HCN54_RS01575	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN54_RS01580	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HCN54_RS01585	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HCN54_RS01590	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HCN54_RS01595	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HCN54_RS01600	ENOG4105WNB	50s ribosomal protein l29
HCN54_RS01605	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HCN54_RS01610	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HCN54_RS01615	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HCN54_RS01620	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN54_RS01625	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HCN54_RS01630	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HCN54_RS01635	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HCN54_RS01640	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HCN54_RS01645	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HCN54_RS01650	ENOG41084HK	50S ribosomal protein L30
HCN54_RS01655	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HCN54_RS01660	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HCN54_RS01665	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HCN54_RS01670	ENOG410864M	50S ribosomal protein L36
HCN54_RS01675	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN54_RS01680	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HCN54_RS01685	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HCN54_RS01690	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN54_RS01695	ENOG4108ZT0	50S ribosomal protein l17
HCN54_RS01705	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HCN54_RS01710	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HCN54_RS01730	ENOG4105C94	Transporter
HCN54_RS01745	ENOG4105C75	arginyL-tRNA synthetase
HCN54_RS01775	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HCN54_RS01805	ENOG4105FE9	pseudouridine synthase
HCN54_RS01830	ENOG4105D7A	ATP-binding protein
HCN54_RS01835	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HCN54_RS01845	ENOG4105CAQ	asparagine synthetase
HCN54_RS01850	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HCN54_RS01860	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HCN54_RS01865	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HCN54_RS01870	ENOG4105CSV	Glutaminase
HCN54_RS01885	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HCN54_RS01890	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HCN54_RS01895	ENOG4105C8N	cysteinyl-tRNA synthetase
HCN54_RS01900	ENOG4105EUJ	GTP cyclohydrolase i
HCN54_RS01915	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HCN54_RS01930	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
HCN54_RS01935	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HCN54_RS01950	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HCN54_RS01955	ENOG4105BZ1	(ABC) transporter
HCN54_RS01965	ENOG4105C8B	TIGR00159 family
HCN54_RS01985	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HCN54_RS01990	ENOG4105M08	Membrane
HCN54_RS02005	ENOG4105ETU	transcriptional activator (TenA
HCN54_RS02010	ENOG4105DWF	phosphomethylpyrimidine kinase
HCN54_RS02015	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HCN54_RS02020	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HCN54_RS02030	ENOG4105CNT	hydrolase family 2
HCN54_RS02060	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HCN54_RS02065	ENOG4105CP7	Triose-phosphate isomerase
HCN54_RS02070	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS02075	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HCN54_RS02090	ENOG4105EEI	dihydropteroate synthase
HCN54_RS02100	ENOG4107R5B	glutamine synthetase
HCN54_RS02130	ENOG4105P8Q	Curli production assembly transport component CsgG
HCN54_RS02140	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HCN54_RS02170	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HCN54_RS02210	ENOG4105F5H	Glycosyl Hydrolase Family 88
HCN54_RS02225	ENOG4105CHR	reductase
HCN54_RS02230	ENOG4105D2H	Uronic isomerase
HCN54_RS02240	ENOG4108UHU	Aldolase
HCN54_RS02245	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HCN54_RS02250	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
HCN54_RS02255	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HCN54_RS02260	ENOG4107QZW	Altronate oxidoreductase
HCN54_RS02265	ENOG4105CTX	dehydratase
HCN54_RS02270	ENOG4105ETE	Transcriptional regulator (LacI family
HCN54_RS02295	ENOG4107TDE	lipolytic protein G-D-S-L family
HCN54_RS02300	ENOG4105DMW	Dehydrogenase reductase
HCN54_RS02305	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HCN54_RS02330	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HCN54_RS02340	ENOG4105E0C	molybdate abc transporter
HCN54_RS02345	ENOG4108IJ6	ABC transporter
HCN54_RS02350	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCN54_RS02355	ENOG4105CEP	NADH dehydrogenase
HCN54_RS02375	ENOG4105C8P	)-transporter
HCN54_RS02380	ENOG4105DJV	ribulose-phosphate 3-epimerase
HCN54_RS02385	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HCN54_RS02395	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HCN54_RS02400	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HCN54_RS02405	ENOG4105II7	pyrroline-5-carboxylate reductase
HCN54_RS02410	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HCN54_RS02415	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HCN54_RS02420	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HCN54_RS02425	ENOG4105D2N	Aldolase
HCN54_RS02435	ENOG4108RWN	rrna methyltransferase
HCN54_RS02440	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
HCN54_RS02450	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HCN54_RS02455	ENOG4105C1A	potassium transporter peripheral membrane
HCN54_RS02460	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HCN54_RS02465	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
HCN54_RS02485	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HCN54_RS02495	ENOG4105C26	Dehydrogenase
HCN54_RS02515	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN54_RS02520	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN54_RS02525	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN54_RS02530	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN54_RS02535	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN54_RS02550	ENOG4105CJ2	(LipO)protein
HCN54_RS02560	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HCN54_RS02630	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HCN54_RS02635	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HCN54_RS02645	ENOG4105VEJ	Heat shock protein
HCN54_RS02660	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HCN54_RS02665	ENOG4108HHA	Transketolase
HCN54_RS02670	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HCN54_RS02685	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HCN54_RS02690	ENOG4105CDU	Replicative dna helicase
HCN54_RS02710	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HCN54_RS02715	ENOG4105ER2	Ompa motb domain protein
HCN54_RS02740	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HCN54_RS02750	ENOG4105CTQ	phosphohexokinase
HCN54_RS02775	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
HCN54_RS02785	ENOG4105DF6	Fe-S oxidoreductase
HCN54_RS02795	ENOG4105DF6	Fe-S oxidoreductase
HCN54_RS02805	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HCN54_RS02810	ENOG4105CPK	Glycosyl transferase (Group 1
HCN54_RS02820	ENOG4105CQB	FAD linked oxidase domain protein
HCN54_RS02835	ENOG4108Z9K	Osmotically inducible protein
HCN54_RS02840	ENOG4105ESV	Glycosyl transferase, family 4
HCN54_RS02845	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HCN54_RS02885	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HCN54_RS02895	ENOG4105DZ0	fad dependent oxidoreductase
HCN54_RS02920	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HCN54_RS02930	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN54_RS02990	ENOG4105DA5	(ABC) transporter
HCN54_RS03025	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HCN54_RS03060	ENOG4105CVR	type I restriction-modification system
HCN54_RS03065	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
HCN54_RS03120	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HCN54_RS03195	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS03205	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HCN54_RS03215	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HCN54_RS03260	ENOG4105E1F	short-chain dehydrogenase reductase
HCN54_RS03265	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HCN54_RS03275	ENOG4105C5H	ABC transporter
HCN54_RS03320	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HCN54_RS03335	ENOG4105CBC	glutamate synthase
HCN54_RS03365	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HCN54_RS03370	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HCN54_RS03395	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
HCN54_RS03400	ENOG4105C98	muts2 protein
HCN54_RS03405	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HCN54_RS03420	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HCN54_RS03445	ENOG4105CPP	Dehydrogenase, E1 component
HCN54_RS03460	ENOG4105ER2	Ompa motb domain protein
HCN54_RS03465	ENOG4105C3M	thioredoxin reductase
HCN54_RS03475	ENOG41065KQ	synthase
HCN54_RS03480	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HCN54_RS03495	ENOG4105NPQ	Pfam:DUF403
HCN54_RS03520	ENOG4105KWG	Pfam:DUF1696
HCN54_RS03525	ENOG4105C93	Xylose Isomerase
HCN54_RS03530	ENOG4105CMG	Carbohydrate kinase
HCN54_RS03550	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HCN54_RS03570	ENOG4105G6Z	alkaline phosphatase
HCN54_RS03585	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HCN54_RS03610	ENOG4105CKI	cobalamin synthesis protein
HCN54_RS03620	ENOG4105EUJ	GTP cyclohydrolase i
HCN54_RS03635	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS03665	ENOG4105ID8	Transcriptional regulator, ARAC family
HCN54_RS03990	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HCN54_RS03995	ENOG4105KT5	UmuD protein
HCN54_RS04035	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HCN54_RS04040	ENOG4108UJU	UPF0301 protein
HCN54_RS04050	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HCN54_RS04055	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN54_RS04075	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HCN54_RS04080	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
HCN54_RS04090	ENOG4105C2J	ABC transporter
HCN54_RS04105	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HCN54_RS04110	ENOG4105CHR	reductase
HCN54_RS04125	ENOG4105EE0	oxidoreductase
HCN54_RS04130	ENOG4107RJ1	sodium solute
HCN54_RS04140	ENOG4108Z03	MAF-like protein
HCN54_RS04190	ENOG4105C5Q	Transcriptional regulator
HCN54_RS04225	ENOG4108UT2	hemolysin iii
HCN54_RS04245	ENOG4107SN7	NLP P60 protein
HCN54_RS04250	ENOG4105CHU	acetyl-coa acetyltransferase
HCN54_RS04300	ENOG4105DY9	regulatoR
HCN54_RS04350	ENOG4105CKK	Glycosyl transferase, family 2
HCN54_RS04355	ENOG4105DY9	regulatoR
HCN54_RS04385	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HCN54_RS04390	ENOG4105CH6	catalase
HCN54_RS04405	ENOG4105W3H	MtN3 and saliva related transmembrane protein
HCN54_RS04425	ENOG410900G	Protein of unknown function (DUF421)
HCN54_RS04440	ENOG4108UUM	single-stranded DNA-binding protein
HCN54_RS04450	ENOG4105W5Q	DNA repair protein (RadC
HCN54_RS04465	ENOG4105VTR	Integrase
HCN54_RS04475	ENOG4107GZ4	SanA protein
HCN54_RS04480	ENOG4108RCM	Nitroreductase
HCN54_RS04490	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HCN54_RS04505	ENOG4105CNU	cell division protein FtsK
HCN54_RS04515	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HCN54_RS04525	ENOG41080RH	Thioredoxin
HCN54_RS04530	ENOG4105D3R	alkyl hydroperoxide reductase
HCN54_RS04535	ENOG4105DFD	Na H antiporter
HCN54_RS04545	ENOG4107QN2	dihydrolipoyl dehydrogenase
HCN54_RS04555	ENOG4105DKW	ABC transporter
HCN54_RS04560	ENOG4105BZU	Histidine kinase
HCN54_RS04570	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HCN54_RS04595	ENOG4108M4U	conserved membrane protein
HCN54_RS04605	ENOG410624X	efflux transporter, rnd family, mfp subunit
HCN54_RS04610	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN54_RS04615	ENOG4105BZU	Histidine kinase
HCN54_RS04620	ENOG4105BZU	Histidine kinase
HCN54_RS04625	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HCN54_RS04665	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HCN54_RS04670	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HCN54_RS04680	ENOG4105VN1	Heat shock protein
HCN54_RS04685	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS04700	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HCN54_RS04710	ENOG4107QN2	dihydrolipoyl dehydrogenase
HCN54_RS04715	ENOG4108RG0	uracil-dna glycosylase
HCN54_RS04725	ENOG4105E0X	reductase
HCN54_RS04730	ENOG4105E0X	reductase
HCN54_RS04735	ENOG4107S9Q	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HCN54_RS04740	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
HCN54_RS04745	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HCN54_RS04755	ENOG4105ERG	peptidase m48, ste24p
HCN54_RS04760	ENOG4105DEU	major facilitator superfamily
HCN54_RS04780	ENOG4105WH9	RNA polymerase
HCN54_RS04785	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HCN54_RS04795	ENOG4105CAT	Cytidine monophosphate kinase
HCN54_RS04800	ENOG4105EQ0	Major Facilitator superfamily
HCN54_RS04805	ENOG4105C26	Dehydrogenase
HCN54_RS04810	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HCN54_RS04825	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HCN54_RS04835	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HCN54_RS04850	ENOG41067SE	Tetr family transcriptional regulator
HCN54_RS04865	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HCN54_RS04895	ENOG4105VG0	50S ribosomal protein l34
HCN54_RS04900	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HCN54_RS04910	ENOG4108S4H	thioesterase Superfamily protein
HCN54_RS04920	ENOG4105CGY	Dna recombination protein
HCN54_RS04925	ENOG4105E0A	ABC, transporter
HCN54_RS04930	ENOG4105EHG	Permease protein
HCN54_RS04960	ENOG4105GFR	rna polymerase sigma factor
HCN54_RS04980	ENOG4105C6K	Malic enzyme
HCN54_RS04985	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HCN54_RS04990	ENOG4107QTF	adenylosuccinate lyase
HCN54_RS05005	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HCN54_RS05030	ENOG4105C1J	atp-dependent rna helicase
HCN54_RS05035	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HCN54_RS05055	ENOG4105KVH	Transcriptional regulator
HCN54_RS05060	ENOG4105C72	UPF0176 protein
HCN54_RS05065	ENOG4107TPS	domain protein
HCN54_RS05080	ENOG4108HRK	Histidine kinase
HCN54_RS05095	ENOG4105DY9	regulatoR
HCN54_RS05115	ENOG4105K6V	RNA polymerase
HCN54_RS05125	ENOG4107TE5	Lipid kinase
HCN54_RS05155	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HCN54_RS05170	ENOG4105EUB	pirin domain protein
HCN54_RS05175	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HCN54_RS05180	ENOG4108HCJ	Hydrolase
HCN54_RS05190	ENOG4105CD3	dihydroorotase
HCN54_RS05195	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HCN54_RS05200	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HCN54_RS05205	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HCN54_RS05245	ENOG4105CNT	hydrolase family 2
HCN54_RS05270	ENOG4105CNT	hydrolase family 2
HCN54_RS05275	ENOG4107QM2	Aldo Keto reductase
HCN54_RS05295	ENOG4105C1G	acyl-Coa dehydrogenase
HCN54_RS05305	ENOG4105CHU	acetyl-coa acetyltransferase
HCN54_RS05320	ENOG4108IQE	Amp-dependent synthetase and ligase
HCN54_RS05350	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HCN54_RS05370	ENOG4105EMN	RNA polymerase sigma factor
HCN54_RS05375	ENOG4105BZ1	(ABC) transporter
HCN54_RS05395	ENOG41081WG	50s ribosomal protein l31
HCN54_RS05405	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCN54_RS05420	ENOG4105E9K	Isocitrate dehydrogenase
HCN54_RS05425	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HCN54_RS05430	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HCN54_RS05445	ENOG4105C0H	protease
HCN54_RS05450	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HCN54_RS05460	ENOG4105HHA	aminodeoxychorismate lyase
HCN54_RS05470	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HCN54_RS05475	ENOG4107ZF2	Phosphatase
HCN54_RS05480	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HCN54_RS05495	ENOG4108TZV	Membrane
HCN54_RS05505	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HCN54_RS05510	ENOG4108MJ3	acetyltransferase
HCN54_RS05515	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HCN54_RS05520	ENOG4108URH	decarboxylase
HCN54_RS05530	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HCN54_RS05545	ENOG4105CGH	5'-nucleotidase
HCN54_RS05550	ENOG4105CGH	5'-nucleotidase
HCN54_RS05560	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HCN54_RS05585	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HCN54_RS05590	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HCN54_RS05605	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HCN54_RS05620	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HCN54_RS05625	ENOG4105EYW	Ion transport protein
HCN54_RS05635	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HCN54_RS05640	ENOG4105DFA	alanine racemase domain protein
HCN54_RS05655	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HCN54_RS05665	ENOG4105C9A	Phoh family
HCN54_RS05670	ENOG4107QWK	SAICAR synthetase
HCN54_RS05675	ENOG4105BZG	amino acid carrier protein
HCN54_RS05690	ENOG4105EQD	regulatoR
HCN54_RS05700	ENOG4105K63	Thioredoxin
HCN54_RS05740	ENOG4105C7Z	Conserved Protein
HCN54_RS05745	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HCN54_RS05750	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HCN54_RS05755	ENOG4105C7W	Xanthine dehydrogenase
HCN54_RS05760	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
HCN54_RS05765	ENOG4105BZP	glycoside hydrolase 15-related
HCN54_RS05770	ENOG4105E6M	Sulphatase-modifying factor protein
HCN54_RS05775	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HCN54_RS05780	ENOG4105C2C	drug resistance transporter, Bcr CflA
HCN54_RS05795	ENOG4105BZ1	(ABC) transporter
HCN54_RS05800	ENOG4107R6T	Involved in the transcription termination process (By similarity)
HCN54_RS05810	ENOG4105VIE	preprotein translocase, subunit YajC
HCN54_RS05830	ENOG4105VCH	membrane
HCN54_RS05840	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HCN54_RS05895	ENOG4105EMU	Dehydrogenase
HCN54_RS05915	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HCN54_RS05920	ENOG4105C3F	Signal peptidase i
HCN54_RS05925	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HCN54_RS05935	ENOG4105FA0	parb-like partition protein
HCN54_RS05940	ENOG4107QJE	Chromosome Partitioning Protein
HCN54_RS05945	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
HCN54_RS05950	ENOG4105D5P	Methylmalonyl-coA mutase
HCN54_RS05955	ENOG4105CMN	Methylmalonyl-coA mutase
HCN54_RS05965	ENOG4105DBI	uridine monophosphokinase
HCN54_RS06000	ENOG4105D7D	AAA ATPase
HCN54_RS06105	ENOG4105BZU	Histidine kinase
HCN54_RS06110	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN54_RS06130	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HCN54_RS06150	ENOG4105CRQ	synthase (Component I)
HCN54_RS06160	ENOG4105CDY	transcriptional regulatory protein
HCN54_RS06170	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HCN54_RS06175	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HCN54_RS06180	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HCN54_RS06190	ENOG4105D06	uba thif-type nad fad binding protein
HCN54_RS06200	ENOG41080H2	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HCN54_RS06205	ENOG4105F4R	Transcriptional regulator mode
HCN54_RS06210	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HCN54_RS06225	ENOG4107QZF	nitrite reductase NADPH large subunit
HCN54_RS06250	ENOG4107RNU	major facilitator superfamily MFS_1
HCN54_RS06255	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HCN54_RS06265	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HCN54_RS06285	ENOG41067HZ	cytochrome C, class I
HCN54_RS06290	ENOG4105D8V	Glucose sorbosone dehydrogenase
HCN54_RS06295	ENOG4105C3M	thioredoxin reductase
HCN54_RS06305	ENOG4105D49	3-dehydroquinate synthase
HCN54_RS06320	ENOG4105DCF	alanine dehydrogenase
HCN54_RS06335	ENOG4108E87	P-loop hydrolase UPF0079
HCN54_RS06340	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN54_RS06345	ENOG4105DCI	Phosphohydrolase
HCN54_RS06350	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN54_RS06355	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN54_RS06360	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN54_RS06365	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HCN54_RS06370	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN54_RS06380	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HCN54_RS06385	ENOG4105CHR	reductase
HCN54_RS06410	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HCN54_RS06415	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HCN54_RS06420	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HCN54_RS06425	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HCN54_RS06430	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HCN54_RS06435	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HCN54_RS06445	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HCN54_RS06450	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HCN54_RS06460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN54_RS06475	ENOG4105C1J	atp-dependent rna helicase
HCN54_RS06495	ENOG4108R99	pseudouridine synthase
HCN54_RS06515	ENOG4105DQ4	alcohol dehydrogenase
HCN54_RS06530	ENOG4105CZ9	Domain of unknown function (DU1801)
HCN54_RS06560	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
HCN54_RS06575	ENOG4105CNG	UPF0061 protein
HCN54_RS06585	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HCN54_RS06600	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
HCN54_RS06625	ENOG4107Y2X	deaminase
HCN54_RS06645	ENOG4105S64	Formate nitrite transporter
HCN54_RS06650	ENOG4107Y2X	deaminase
HCN54_RS06655	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HCN54_RS06660	ENOG4105DU1	integral membrane protein, terc
HCN54_RS06690	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HCN54_RS06695	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HCN54_RS06720	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HCN54_RS06725	ENOG4105K89	arsenate reductase
HCN54_RS06740	ENOG4105C9Q	fumarate hydratase class II
HCN54_RS06745	ENOG4105CRE	cytochrome C
HCN54_RS06755	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HCN54_RS06760	ENOG4105F0N	pyrophosphate phospho-hydrolase
HCN54_RS06780	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HCN54_RS06785	ENOG4108VVK	transcriptional Regulator, AsnC
HCN54_RS06805	ENOG4108HRK	Histidine kinase
HCN54_RS06810	ENOG4105BZU	Histidine kinase
HCN54_RS06815	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HCN54_RS06820	ENOG4105DF5	DNA topoisomerase IV, subunit A
HCN54_RS06825	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HCN54_RS06840	ENOG4105D7N	magnesium and cobalt transport protein CorA
HCN54_RS06845	ENOG4107R7Y	intracellular protease Pfpi family
HCN54_RS06850	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HCN54_RS06855	ENOG4105D7W	serine acetyltransferase
HCN54_RS06860	ENOG4105C6T	cysteine synthase
HCN54_RS06900	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HCN54_RS06930	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HCN54_RS06990	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HCN54_RS07000	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HCN54_RS07010	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HCN54_RS07025	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HCN54_RS07035	ENOG4105SFS	phosphoesterase RecJ domain protein
HCN54_RS07045	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HCN54_RS07055	ENOG4105CIN	aminoacyl-histidine dipeptidase
HCN54_RS07060	ENOG4105KZX	Pterin carbinolamine dehydratase
HCN54_RS07065	ENOG4105CDY	transcriptional regulatory protein
HCN54_RS07070	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HCN54_RS07100	ENOG4107QI6	Cysteine desulfurase
HCN54_RS07125	ENOG4105P4J	Allophanate hydrolase, subunit 1
HCN54_RS07130	ENOG4105E7W	lamb ycsf family protein
HCN54_RS07135	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HCN54_RS07145	ENOG4105C0P	Mg chelatase subunit ChlI
HCN54_RS07155	ENOG4108IUM	Glycogen debranching enzyme
HCN54_RS07170	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HCN54_RS07195	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HCN54_RS07205	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HCN54_RS07210	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HCN54_RS07265	ENOG4105ENX	hydrolase
HCN54_RS07290	ENOG4108UUM	single-stranded DNA-binding protein
HCN54_RS07300	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
HCN54_RS07310	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS07320	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS07355	ENOG4105CUY	Mechanosensitive ion channel
HCN54_RS07365	ENOG4105C6Z	Gluconate
HCN54_RS07370	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HCN54_RS07390	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HCN54_RS07395	ENOG4105EP9	oxidoreductase
HCN54_RS07410	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HCN54_RS07445	ENOG4108YZA	Nitrogen regulatory protein pii
HCN54_RS07510	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HCN54_RS07520	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HCN54_RS07540	ENOG4108I0Y	(ABC) transporter
HCN54_RS07545	ENOG4108UJV	acyl-CoA thioesterase i
HCN54_RS07575	ENOG4105CEP	NADH dehydrogenase
HCN54_RS07580	ENOG410904A	RNA polymerase
HCN54_RS07610	ENOG4108V06	Glutathione peroxidase
HCN54_RS07615	ENOG4105K56	Transcriptional regulator
HCN54_RS07640	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HCN54_RS07650	ENOG4105EN6	Membrane
HCN54_RS07680	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN54_RS07690	ENOG4105C22	threonyL-tRNA synthetase
HCN54_RS07695	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HCN54_RS07700	ENOG4105VJV	50s ribosomal protein L35
HCN54_RS07705	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HCN54_RS07715	ENOG4105VRS	hydrolase family 18
HCN54_RS07720	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HCN54_RS07735	ENOG4108I0Z	Aconitate hydratase
HCN54_RS07740	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN54_RS07745	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HCN54_RS07765	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HCN54_RS07775	ENOG4105BZU	Histidine kinase
HCN54_RS07780	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HCN54_RS07785	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HCN54_RS07790	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HCN54_RS07795	ENOG4105C8Y	Acetylornithine aminotransferase
HCN54_RS07800	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HCN54_RS07820	ENOG4108RWN	rrna methyltransferase
HCN54_RS07825	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
HCN54_RS07830	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HCN54_RS07840	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HCN54_RS07860	ENOG4105C8Y	Acetylornithine aminotransferase
HCN54_RS07900	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HCN54_RS07910	ENOG4105C7H	Helicase, RecD TraA family
HCN54_RS07935	ENOG4105C6E	dna polymerase iii
HCN54_RS07960	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HCN54_RS07970	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HCN54_RS07975	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HCN54_RS07985	ENOG4105CXT	aspartate transcarbamylase
HCN54_RS07990	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HCN54_RS08015	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HCN54_RS08020	ENOG4108URH	decarboxylase
HCN54_RS08030	ENOG4105CPP	Dehydrogenase, E1 component
HCN54_RS08050	ENOG4105QNR	S1 RNA binding domain protein
HCN54_RS08060	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HCN54_RS08065	ENOG4105E4F	Isochorismate synthase
HCN54_RS08070	ENOG4105KA0	thioesterase Superfamily protein
HCN54_RS08095	ENOG4105CFG	Acts as a chaperone (By similarity)
HCN54_RS08105	ENOG4105EJQ	L-serine dehydratase
HCN54_RS08120	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HCN54_RS08125	ENOG4105C34	Pseudouridine synthase
HCN54_RS08145	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HCN54_RS08150	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HCN54_RS08155	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HCN54_RS08170	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HCN54_RS08190	ENOG4105CH7	arginosuccinase
HCN54_RS08195	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HCN54_RS08200	ENOG4107T6X	nag kinase
HCN54_RS08210	ENOG4105C8Y	Acetylornithine aminotransferase
HCN54_RS08220	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HCN54_RS08225	ENOG4105CDH	Citrulline--aspartate ligase
HCN54_RS08235	ENOG4105C26	Dehydrogenase
HCN54_RS08240	ENOG4105C7B	Threonine dehydratase
HCN54_RS08245	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HCN54_RS08250	ENOG4108ZP8	Acetolactate synthase small subunit
HCN54_RS08255	ENOG4105C7K	acetolactate synthase
HCN54_RS08260	ENOG4105C01	Dihydroxy-acid dehydratase
HCN54_RS08265	ENOG4107SET	aldo keto reductase
HCN54_RS08290	ENOG4105C3G	gtp-binding protein
HCN54_RS08295	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HCN54_RS08305	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HCN54_RS08310	ENOG4108JQ1	Dehydrogenase
HCN54_RS08330	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HCN54_RS08340	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HCN54_RS08345	ENOG4105D98	threonine synthase
HCN54_RS08350	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HCN54_RS08365	ENOG4105CD3	dihydroorotase
HCN54_RS08400	ENOG4105EUJ	GTP cyclohydrolase i
HCN54_RS08405	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HCN54_RS08410	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HCN54_RS08420	ENOG4105BZU	Histidine kinase
HCN54_RS08425	ENOG4105BZU	Histidine kinase
HCN54_RS08435	ENOG4105CD3	dihydroorotase
HCN54_RS08465	ENOG4105CUT	histidyl-tRNA synthetase
HCN54_RS08480	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HCN54_RS08485	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HCN54_RS08490	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
HCN54_RS08495	ENOG4108NEV	two component transcriptional regulator, LytTR family
HCN54_RS08500	ENOG4105C25	Primosomal protein n'
HCN54_RS08510	ENOG4107U9T	Pfam:Ribonuclease_BN
HCN54_RS08515	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HCN54_RS08520	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HCN54_RS08535	ENOG4105DXN	mazG family
HCN54_RS08545	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HCN54_RS08550	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HCN54_RS08555	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HCN54_RS08570	ENOG4106WTF	Glycosyl transferase, family 2
HCN54_RS08595	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HCN54_RS08610	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HCN54_RS08625	ENOG4105CJ1	ABC, transporter
HCN54_RS08645	ENOG4105BZP	glycoside hydrolase 15-related
HCN54_RS08650	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HCN54_RS08670	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HCN54_RS08675	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HCN54_RS08680	ENOG4107RUZ	Sss sodium solute transporter superfamily
HCN54_RS08690	ENOG4105EF1	ribulokinase
HCN54_RS08705	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HCN54_RS08710	ENOG4107SYN	Glycosyl hydrolases family 43
HCN54_RS08720	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HCN54_RS08750	ENOG4105EWK	phytoene
HCN54_RS08770	ENOG41074B2	UPF0747 protein
HCN54_RS08785	ENOG4107RAN	Peptidase, M16
HCN54_RS08800	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HCN54_RS08810	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HCN54_RS08815	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HCN54_RS08825	ENOG41083ND	50S ribosomal protein L33
HCN54_RS08830	ENOG4105KDC	50s ribosomal protein l28
HCN54_RS08835	ENOG4105CEV	competence damage-inducible protein
HCN54_RS08855	ENOG4108IRC	dna polymerase iii
HCN54_RS08875	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HCN54_RS08885	ENOG4107QQG	Dehydrogenase
HCN54_RS08890	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HCN54_RS08895	ENOG4108RMU	ferritin dps family protein
HCN54_RS08900	ENOG4105D64	Mechanosensitive ion channel
HCN54_RS08915	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HCN54_RS08935	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS08955	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN54_RS08970	ENOG41080WS	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HCN54_RS08980	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HCN54_RS08990	ENOG4105DEN	Luciferase family
HCN54_RS09020	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN54_RS09025	ENOG4105EXW	epimerase dehydratase
HCN54_RS09030	ENOG4105J0Q	Transcriptional regulator
HCN54_RS09040	ENOG41088PD	hydrolase
HCN54_RS09060	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HCN54_RS09080	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN54_RS09115	ENOG4107P26	
HCN54_RS09135	ENOG4105NF4	modulator of drug activity
HCN54_RS09140	ENOG4107653	Transcriptional regulator
HCN54_RS09150	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS09155	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HCN54_RS09170	ENOG4105C1J	atp-dependent rna helicase
HCN54_RS09185	ENOG4107RE3	peptidase, S41
HCN54_RS09210	ENOG4105FTV	AraC Family Transcriptional Regulator
HCN54_RS09235	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HCN54_RS09240	ENOG4105DJT	lAO AO transport system ATPase
HCN54_RS09250	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HCN54_RS09265	ENOG4107RJ1	sodium solute
HCN54_RS09285	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HCN54_RS09320	ENOG4105E0K	tonB-dependent siderophore receptor
HCN54_RS09355	ENOG4107RH8	nuclease SbcCD subunit D
HCN54_RS09360	ENOG4105EYH	Exonuclease
HCN54_RS09365	ENOG4108S4H	thioesterase Superfamily protein
HCN54_RS09370	ENOG4107RAQ	aminopeptidase
HCN54_RS09400	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS09405	ENOG4105CSM	endonuclease III
HCN54_RS09420	ENOG4105IIU	Aminopeptidase
HCN54_RS09440	ENOG4105FJR	Lmbe family
HCN54_RS09445	ENOG4105C28	cystathionine
HCN54_RS09455	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
HCN54_RS09465	ENOG4105NF4	modulator of drug activity
HCN54_RS09470	ENOG4105KVH	Transcriptional regulator
HCN54_RS09475	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HCN54_RS09480	ENOG4105DUM	transcriptional regulator, lysR family
HCN54_RS09485	ENOG4105HMI	Membrane
HCN54_RS09510	ENOG4105CAK	Cell division ATP-binding protein ftsE
HCN54_RS09525	ENOG4105K64	Glycosyl transferase, family 2
HCN54_RS09535	ENOG4105E2K	Glycosyl transferase (Group 1
HCN54_RS09570	ENOG4105CI3	gtp-binding protein typa
HCN54_RS09575	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HCN54_RS09620	ENOG4105CT7	inner membrane cred family protein
HCN54_RS09625	ENOG4107P26	
HCN54_RS09665	ENOG4105EPC	oxidoreductase
HCN54_RS09710	ENOG4105CA0	peroxidase
HCN54_RS09755	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HCN54_RS09810	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
HCN54_RS09820	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HCN54_RS09835	ENOG41080HJ	6-phospho 3-hexuloisomerase
HCN54_RS09850	ENOG4105CKW	Inner membrane protein yedI
HCN54_RS09870	ENOG4105GR3	Histidine kinase
HCN54_RS10015	ENOG4108QUU	Morphogenesis Protein
HCN54_RS10105	ENOG4105DVT	helicase
HCN54_RS10110	ENOG4105DHU	Bile acid
HCN54_RS10125	ENOG4105TT1	Ragb susd domain-containing protein
HCN54_RS10160	ENOG4105CWX	Alpha-1,2-mannosidase
HCN54_RS10185	ENOG4105CWX	Alpha-1,2-mannosidase
HCN54_RS10195	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HCN54_RS10240	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HCN54_RS10250	ENOG4108XM1	transcriptional regulator AsnC family
HCN54_RS10255	ENOG4105EPC	oxidoreductase
HCN54_RS10275	ENOG4105EDR	glucose galactose transporter
HCN54_RS10290	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HCN54_RS10305	ENOG4107TDE	lipolytic protein G-D-S-L family
HCN54_RS10310	ENOG4105CNT	hydrolase family 2
HCN54_RS10315	ENOG4107TDE	lipolytic protein G-D-S-L family
HCN54_RS10320	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HCN54_RS10330	ENOG4105C9F	isomerase
HCN54_RS10335	ENOG4105DET	Rhamnulokinase
HCN54_RS10340	ENOG4105DMF	Dehydrogenase
HCN54_RS10370	ENOG4105CX8	fg-gap repeat protein
HCN54_RS10420	ENOG4105BZU	Histidine kinase
HCN54_RS10435	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN54_RS10460	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HCN54_RS10535	ENOG4105D75	Capsular exopolysaccharide family
HCN54_RS10545	ENOG4105D3Q	Sugar transferase
HCN54_RS10550	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HCN54_RS10565	ENOG4105CGN	Glycosyl transferase (Group 1
HCN54_RS10600	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HCN54_RS10610	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HCN54_RS10615	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HCN54_RS10620	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HCN54_RS10635	ENOG41085GJ	domain protein
HCN54_RS10645	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS10655	ENOG4108RCM	Nitroreductase
HCN54_RS10665	ENOG4105CRQ	synthase (Component I)
HCN54_RS10670	ENOG4105DDQ	anthranilate synthase
HCN54_RS10675	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HCN54_RS10680	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HCN54_RS10685	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HCN54_RS10690	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HCN54_RS10700	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HCN54_RS10705	ENOG4105CHH	sulfate transporter
HCN54_RS10715	ENOG4105E0K	tonB-dependent siderophore receptor
HCN54_RS10730	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HCN54_RS10735	ENOG4105CPF	Cell wall formation (By similarity)
HCN54_RS10745	ENOG4105C34	Pseudouridine synthase
HCN54_RS10765	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HCN54_RS10780	ENOG410667J	hydrolase
HCN54_RS10795	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HCN54_RS10800	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HCN54_RS10810	ENOG4108RWI	nicotinamidase
HCN54_RS10845	ENOG41063ZK	Transcriptional Regulator AraC Family
HCN54_RS10875	ENOG4105DG6	mannose-6-phosphate isomerase
HCN54_RS10985	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HCN54_RS10995	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN54_RS11000	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN54_RS11005	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HCN54_RS11010	ENOG4107VNI	ribosomal protein l10
HCN54_RS11015	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HCN54_RS11020	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HCN54_RS11040	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HCN54_RS11065	ENOG4105MS2	ribosomal subunit Interface protein
HCN54_RS11070	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS11075	ENOG41083X6	30S ribosomal protein S21
HCN54_RS11080	ENOG4105C1G	acyl-Coa dehydrogenase
HCN54_RS11090	ENOG4105BZG	amino acid carrier protein
HCN54_RS11100	ENOG4107SVH	Potassium channel protein
HCN54_RS11135	ENOG4105EHZ	conserved protein UCP016719
HCN54_RS11145	ENOG4107S1E	Beta-lactamase
HCN54_RS11195	ENOG4105C5H	ABC transporter
HCN54_RS11210	ENOG4107QX3	carboxylase
HCN54_RS11215	ENOG4105F27	Major Facilitator
HCN54_RS11235	ENOG4107FCW	Abortive infection protein
HCN54_RS11240	ENOG4105DTQ	mandelate racemase muconate lactonizing
HCN54_RS11245	ENOG4107W2A	UPF0173 metal-dependent hydrolase
HCN54_RS11250	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HCN54_RS11260	ENOG4108QY0	Membrane
HCN54_RS11270	ENOG4105CPC	Aldo Keto reductase
HCN54_RS11280	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HCN54_RS11300	ENOG4105EA8	2-Nitropropane dioxygenase
HCN54_RS11305	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HCN54_RS11315	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HCN54_RS11320	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HCN54_RS11335	ENOG4107QI1	Mate efflux family protein
HCN54_RS11355	ENOG4105CSR	polyphosphate kinase 2
HCN54_RS11360	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN54_RS11370	ENOG4105EGS	Mechanosensitive ion channel
HCN54_RS11380	ENOG4108IUX	(ABC) transporter
HCN54_RS11385	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HCN54_RS11390	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN54_RS11405	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HCN54_RS11415	ENOG4107T8Q	Glycosyl transferase (Group 1
HCN54_RS11450	ENOG4107SBE	Glycosyl transferase (Group 1
HCN54_RS11460	ENOG4105VC4	domain protein
HCN54_RS11465	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
HCN54_RS11470	ENOG4105D2T	synthase
HCN54_RS11475	ENOG4105F0R	Cytidylyltransferase
HCN54_RS11515	ENOG4107QJZ	Glycosyl transferase, family 2
HCN54_RS11540	ENOG4105K64	Glycosyl transferase, family 2
HCN54_RS11555	ENOG4105EY8	ABC transporter
HCN54_RS11565	ENOG4105D75	Capsular exopolysaccharide family
HCN54_RS11575	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN54_RS11580	ENOG4105C2X	Arabinose 5-phosphate isomerase
HCN54_RS11585	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HCN54_RS11595	ENOG4108IUZ	ABC transporter
HCN54_RS11605	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HCN54_RS11625	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HCN54_RS11630	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HCN54_RS11640	ENOG4105D1Q	UPF0246 protein
HCN54_RS11645	ENOG4105C19	ABC transporter
HCN54_RS11655	ENOG4105C5H	ABC transporter
HCN54_RS11675	ENOG4106K7D	Major facilitator family transporter
HCN54_RS11690	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HCN54_RS11695	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HCN54_RS11700	ENOG4105BZU	Histidine kinase
HCN54_RS11705	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HCN54_RS11710	ENOG4105EGD	dinuclear metal center protein, YbgI family
HCN54_RS11730	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HCN54_RS11745	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HCN54_RS11750	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HCN54_RS11770	ENOG4105CHR	reductase
HCN54_RS11785	ENOG4105C2C	drug resistance transporter, Bcr CflA
HCN54_RS11795	ENOG4105C2I	pirin domain protein
HCN54_RS11810	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HCN54_RS11815	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HCN54_RS11825	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HCN54_RS11855	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
HCN54_RS11885	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HCN54_RS11915	ENOG4108YBP	pseudouridine synthase
HCN54_RS11940	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS12040	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HCN54_RS12070	ENOG4108Z7R	Chaperone CsaA
HCN54_RS12095	ENOG4108Z4K	mutator MutT protein
HCN54_RS12100	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HCN54_RS12115	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HCN54_RS12120	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HCN54_RS12130	ENOG4105KNE	Phosphatidate cytidylyltransferase
HCN54_RS12135	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HCN54_RS12145	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HCN54_RS12165	ENOG4107R0I	Cell wall formation (By similarity)
HCN54_RS12180	ENOG4105K64	Glycosyl transferase, family 2
HCN54_RS12190	ENOG4105K3M	)-transporter
HCN54_RS12210	ENOG4105D5P	Methylmalonyl-coA mutase
HCN54_RS12245	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HCN54_RS12250	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HCN54_RS12265	ENOG4107SC0	ferredoxin--NADP reductase
HCN54_RS12305	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HCN54_RS12340	ENOG4105W5Q	DNA repair protein (RadC
HCN54_RS12350	ENOG4108UUM	single-stranded DNA-binding protein
HCN54_RS12355	ENOG4105CZN	Potassium uptake protein
HCN54_RS12375	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HCN54_RS12390	ENOG4105TT1	Ragb susd domain-containing protein
HCN54_RS12400	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HCN54_RS12410	ENOG41061MV	Arylsulfatase
HCN54_RS12420	ENOG4107HQ7	repeat protein
HCN54_RS12435	ENOG4107QNK	)-transporter
HCN54_RS12470	ENOG41063TF	transcriptional regulator (AraC
HCN54_RS12485	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS12495	ENOG4105KTH	gatB Yqey
HCN54_RS12500	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HCN54_RS12505	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HCN54_RS12515	ENOG4105DFU	Cell wall formation (By similarity)
HCN54_RS12520	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HCN54_RS12525	ENOG4105CNI	cell division protein FtsW
HCN54_RS12530	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HCN54_RS12535	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HCN54_RS12540	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HCN54_RS12545	ENOG4105CJN	penicillin-binding protein
HCN54_RS12555	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HCN54_RS12560	ENOG4107YM1	mraZ protein
HCN54_RS12570	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HCN54_RS12590	ENOG4107RW9	nh(3)-dependent nad( ) synthetase
HCN54_RS12595	ENOG4108WQH	regulatoR
HCN54_RS12600	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HCN54_RS12625	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HCN54_RS12630	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HCN54_RS12660	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HCN54_RS12665	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HCN54_RS12675	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HCN54_RS12685	ENOG4105CHM	Aminotransferase
HCN54_RS12705	ENOG4105EEQ	Na H antiporter
HCN54_RS12720	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HCN54_RS12725	ENOG4108A04	Beta-lactamase
HCN54_RS12745	ENOG4109015	Biopolymer transport protein exbD tolR
HCN54_RS12755	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HCN54_RS12765	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HCN54_RS12770	ENOG4105C1G	acyl-Coa dehydrogenase
HCN54_RS12775	ENOG4107RUZ	Sss sodium solute transporter superfamily
HCN54_RS12780	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HCN54_RS12785	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HCN54_RS12795	ENOG4105CMR	udp-glucose 4-epimerase
HCN54_RS12800	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HCN54_RS12805	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HCN54_RS12815	ENOG4105C72	UPF0176 protein
HCN54_RS12845	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS12880	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HCN54_RS12920	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HCN54_RS12930	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HCN54_RS12935	ENOG41086DT	Membrane protein of unknown function
HCN54_RS12945	ENOG4105ISI	outer membrane protein, OMPP1 FadL TodX family
HCN54_RS12950	ENOG4105EV9	Alpha Beta Hydrolase
HCN54_RS12955	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HCN54_RS12965	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HCN54_RS12975	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HCN54_RS12980	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCN54_RS12995	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HCN54_RS13015	ENOG4105D64	Mechanosensitive ion channel
HCN54_RS13020	ENOG41072GX	Peptidase M22 Glycoprotease
HCN54_RS13040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS13045	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS13050	ENOG4105C19	ABC transporter
HCN54_RS13060	ENOG4108SJC	Membrane
HCN54_RS13065	ENOG4108KF3	Electron transport protein SCO1 SenC
HCN54_RS13085	ENOG4105CCU	oxidase (Subunit III)
HCN54_RS13090	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HCN54_RS13120	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HCN54_RS13130	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HCN54_RS13135	ENOG4105C6K	Malic enzyme
HCN54_RS13145	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HCN54_RS13155	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HCN54_RS13160	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HCN54_RS13165	ENOG4105Z4T	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HCN54_RS13185	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HCN54_RS13190	ENOG4107SFQ	iron-sulfur binding
HCN54_RS13205	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HCN54_RS13210	ENOG4105CHV	Transcription elongation factor NusA
HCN54_RS13215	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
HCN54_RS13245	ENOG4105K63	Thioredoxin
HCN54_RS13265	ENOG4105F8V	Hydrolase, tatD family
HCN54_RS13275	ENOG4105HDK	L-asparaginase
HCN54_RS13295	ENOG4109015	Biopolymer transport protein exbD tolR
HCN54_RS13315	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HCN54_RS13325	ENOG4105ENE	Histidine kinase
HCN54_RS13350	ENOG4105C5S	asparaginyl-tRNA synthetase
HCN54_RS13365	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HCN54_RS13370	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HCN54_RS13375	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HCN54_RS13380	ENOG4105CE9	30S ribosomal protein S2
HCN54_RS13385	ENOG4108UJD	30S ribosomal protein S9
HCN54_RS13390	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HCN54_RS13400	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS13420	ENOG4105C2M	dna polymerase I
HCN54_RS13430	ENOG4105C7S	Dehydrogenase
HCN54_RS13435	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HCN54_RS13455	ENOG4105KBX	Transcriptional regulator, TetR family
HCN54_RS13475	ENOG4105C9M	aspartyl-trna synthetase
HCN54_RS13495	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HCN54_RS13500	ENOG4108Z6B	deaminase
HCN54_RS13525	ENOG4105CH6	catalase
HCN54_RS13560	ENOG4105CHM	Aminotransferase
HCN54_RS13570	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HCN54_RS13585	ENOG4105CN1	protease
HCN54_RS13590	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HCN54_RS13635	ENOG4105BZU	Histidine kinase
HCN54_RS13640	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN54_RS13670	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HCN54_RS13685	ENOG4105VG1	fes assembly suf system protein
HCN54_RS13695	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HCN54_RS13705	ENOG4105C9B	Cysteine desulfurase
HCN54_RS13725	ENOG4108Z4V	iron-sulfur cluster assembly
HCN54_RS13730	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HCN54_RS13740	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HCN54_RS13800	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN54_RS13805	ENOG4105BZU	Histidine kinase
HCN54_RS13825	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HCN54_RS13840	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HCN54_RS13845	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HCN54_RS13855	ENOG4108IUK	alpha amylase, catalytic
HCN54_RS13875	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS13890	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HCN54_RS13895	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HCN54_RS13900	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HCN54_RS13905	ENOG4105DTN	riboflavin biosynthesis protein ribF
HCN54_RS13915	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HCN54_RS13930	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HCN54_RS13935	ENOG4105CJW	magnesium transporter
HCN54_RS13945	ENOG4108JQ1	Dehydrogenase
HCN54_RS13970	ENOG4105CFH	Aspartokinase
HCN54_RS13990	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
HCN54_RS13995	ENOG4107QRT	dEAD DEAH box helicase
HCN54_RS14000	ENOG4108SQ4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HCN54_RS14015	ENOG4107QN2	dihydrolipoyl dehydrogenase
HCN54_RS14020	ENOG4108JA2	transcriptioN-repair coupling factor
HCN54_RS14025	ENOG41080R2	UPF0102 protein
HCN54_RS14030	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HCN54_RS14035	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HCN54_RS14040	ENOG41082IR	Excinuclease ABC C subunit domain protein
HCN54_RS14055	ENOG4105DGU	Histone deacetylase
HCN54_RS14070	ENOG4107QN1	sodium solute
HCN54_RS14075	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HCN54_RS14080	ENOG4108UUM	single-stranded DNA-binding protein
HCN54_RS14085	ENOG4105C4K	Nad synthetase
HCN54_RS14090	ENOG4108YYS	metal-dependent hydrolase (By similarity)
HCN54_RS14100	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HCN54_RS14115	ENOG4105CFH	Aspartokinase
HCN54_RS14125	ENOG4105C9K	Endothelin-converting enzyme 1
HCN54_RS14190	ENOG4105F6E	Acyl-transferase
HCN54_RS14205	ENOG4105VZ8	Transcriptional regulator
HCN54_RS14215	ENOG4105BZW	Glycerate kinase
HCN54_RS14220	ENOG4105C6Z	Gluconate
HCN54_RS14235	ENOG4108KF3	Electron transport protein SCO1 SenC
HCN54_RS14245	ENOG4105CE1	Ferrous iron transport protein b
HCN54_RS14275	ENOG4107RPQ	ABC transporter
HCN54_RS14280	ENOG4105D05	Receptor
HCN54_RS14290	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
HCN54_RS14300	ENOG4105CHR	reductase
HCN54_RS14320	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HCN54_RS14325	ENOG4108Y6J	UPF0403 protein
HCN54_RS14330	ENOG4105CMQ	Chloride channel
HCN54_RS14345	ENOG4105VEQ	Cold shock protein
HCN54_RS14350	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HCN54_RS14360	ENOG4105MJ2	Competence protein
HCN54_RS14370	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HCN54_RS14385	ENOG4105CGK	Exodeoxyribonuclease III
HCN54_RS14390	ENOG4105ER2	Ompa motb domain protein
HCN54_RS14395	ENOG4105CPC	Aldo Keto reductase
HCN54_RS14400	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HCN54_RS14410	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HCN54_RS14415	ENOG4105C1G	acyl-Coa dehydrogenase
HCN54_RS14435	ENOG4105D6J	arsenicaL-resistance protein
HCN54_RS14440	ENOG4105FAA	peptidase M23
HCN54_RS14455	ENOG4105E39	Enoyl-CoA hydratase
HCN54_RS14460	ENOG4108HWS	Histidine kinase
HCN54_RS14475	ENOG4107QJQ	Mate efflux family protein
HCN54_RS14480	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HCN54_RS14495	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HCN54_RS14500	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HCN54_RS14510	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HCN54_RS14520	ENOG4105EXN	Sulfate transport protein CysZ
HCN54_RS14530	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HCN54_RS14535	ENOG4105D52	delta-aminolevulinic acid dehydratase
HCN54_RS14570	ENOG4105D3R	alkyl hydroperoxide reductase
HCN54_RS14575	ENOG4107QP7	CoA-transferase subunit A
HCN54_RS14580	ENOG4108JQC	penicillin-binding protein 1A
HCN54_RS14585	ENOG410647Z	gliding motility-associated lipoprotein GldH
HCN54_RS14590	ENOG4105MA4	psp1 domain protein
HCN54_RS14595	ENOG4105C72	UPF0176 protein
HCN54_RS14600	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HCN54_RS14610	ENOG4105EMN	RNA polymerase sigma factor
HCN54_RS14640	ENOG4105NAU	thioesterase Superfamily protein
HCN54_RS14645	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HCN54_RS14665	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HCN54_RS14670	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HCN54_RS14685	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HCN54_RS14695	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HCN54_RS14700	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HCN54_RS14705	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HCN54_RS14715	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HCN54_RS14740	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HCN54_RS14750	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HCN54_RS14780	ENOG4105DVP	Adenine-specific
HCN54_RS14800	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HCN54_RS14820	ENOG4108KMV	Glycosyl transferase (Group 1
HCN54_RS14860	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HCN54_RS14870	ENOG41068JE	domain protein
HCN54_RS14875	ENOG4105BZA	Phosphoglycerate kinase
HCN54_RS14880	ENOG4107QRG	dna polymerase iii
HCN54_RS14895	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HCN54_RS14900	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HCN54_RS14910	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HCN54_RS14920	ENOG4107RIZ	hflk protein
HCN54_RS14940	ENOG4105CX6	glutaminyL-tRNA synthetase
HCN54_RS14965	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HCN54_RS14970	ENOG4107YB6	acetyltransferase, (GNAT) family
HCN54_RS14980	ENOG4105CN1	protease
HCN54_RS15005	ENOG4105C8F	Beta-lactamase domain protein
HCN54_RS15025	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HCN54_RS15035	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HCN54_RS15045	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HCN54_RS15050	ENOG4108ZVT	methylmalonyl-coA epimerase
HCN54_RS15065	ENOG4108R6K	riboflavin synthase, subunit alpha
HCN54_RS15070	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HCN54_RS15080	ENOG4105WXV	50S ribosomal protein L32
HCN54_RS15085	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN54_RS15090	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HCN54_RS15095	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HCN54_RS15105	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HCN54_RS15115	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HCN54_RS15120	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HCN54_RS15125	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HCN54_RS15130	ENOG4107T8J	thymidine kinase
HCN54_RS15160	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HCN54_RS15170	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HCN54_RS15175	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HCN54_RS15205	ENOG4107R4J	Chloride channel
HCN54_RS15225	ENOG4105UYK	outer membrane protein a
HCN54_RS15235	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HCN54_RS15245	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HCN54_RS15255	ENOG4108B1Q	Ribonuclease
HCN54_RS15260	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HCN54_RS15265	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HCN54_RS15270	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HCN54_RS15275	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HCN54_RS15320	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HCN54_RS15330	ENOG4108JQB	penicillin-binding protein 1C
HCN54_RS15335	ENOG4107S85	alpha-2-macroglobulin domain protein
HCN54_RS15350	ENOG4105D44	asparaginase
HCN54_RS15355	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HCN54_RS15360	ENOG4105C26	Dehydrogenase
HCN54_RS15385	ENOG4105EMU	Dehydrogenase
HCN54_RS15390	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN54_RS15410	ENOG4107QVM	von Willebrand factor, type A
HCN54_RS15430	ENOG41077A9	carbonic anhydrase
HCN54_RS15435	ENOG4105E96	Colicin v production protein
HCN54_RS15450	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HCN54_RS15465	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HCN54_RS15475	ENOG4109066	lysm domain bon superfamily protein
HCN54_RS15480	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HCN54_RS15485	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HCN54_RS15490	ENOG4105DSJ	YicC domain protein
HCN54_RS15510	ENOG4105CIB	oxidoreductase Domain protein
HCN54_RS15515	ENOG4105EAA	nucleoside
HCN54_RS15590	ENOG4105C28	cystathionine
HCN54_RS15600	ENOG4107R37	Glutamate dehydrogenase
HCN54_RS15610	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
HCN54_RS15615	ENOG4105D05	Receptor
HCN54_RS15635	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HCN54_RS15650	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HCN54_RS15655	ENOG4105BZU	Histidine kinase
HCN54_RS15660	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HCN54_RS15675	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HCN54_RS15680	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HCN54_RS15685	ENOG4105D78	K07001 NTE family protein
HCN54_RS15690	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HCN54_RS15695	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HCN54_RS15705	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HCN54_RS15715	ENOG4107QP8	phosphohexose isomerase
HCN54_RS15730	ENOG4108K8S	endonuclease I
HCN54_RS15740	ENOG4107T6F	Xaa-Pro aminopeptidase
HCN54_RS15770	ENOG4105E33	succinate dehydrogenase
HCN54_RS15775	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HCN54_RS15790	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HCN54_RS15795	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HCN54_RS15800	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HCN54_RS15810	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HCN54_RS15815	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HCN54_RS15820	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HCN54_RS15830	ENOG4106IPI	cyclase, family
HCN54_RS15840	ENOG4105VMP	Transcriptional regulator
HCN54_RS15850	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN54_RS15855	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HCN54_RS15875	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HCN54_RS15880	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HCN54_RS15895	ENOG4105C03	ribonuclease
HCN54_RS15900	ENOG4105K70	DNA-binding protein
HCN54_RS15905	ENOG4105CEN	a g-specific adenine glycosylase
HCN54_RS15910	ENOG4108UUM	single-stranded DNA-binding protein
HCN54_RS15915	ENOG4105C37	(CBS) domain
HCN54_RS15945	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HCN54_RS15950	ENOG4105K46	50S ribosomal protein l27
HCN54_RS15980	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HCN54_RS15990	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
HCN54_RS15995	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HCN54_RS16025	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN54_RS16030	ENOG4105BZU	Histidine kinase
HCN54_RS16045	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HCN54_RS16060	ENOG4107VIJ	nudix hydrolase
HCN54_RS16065	ENOG4105BZU	Histidine kinase
HCN54_RS16070	ENOG4107RT4	flavin reductase domain protein
HCN54_RS16080	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HCN54_RS16085	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HCN54_RS16100	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HCN54_RS16105	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HCN54_RS16115	ENOG4107RJ9	Cell division protein FtsX
HCN54_RS16125	ENOG4105C8T	Leucyl-tRNA synthetase
HCN54_RS16150	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HCN54_RS16155	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HCN54_RS16165	ENOG4105CD3	dihydroorotase
HCN54_RS16170	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HCN54_RS16185	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HCN54_RS16190	ENOG4105M08	Membrane
HCN54_RS16200	ENOG4108VVK	transcriptional Regulator, AsnC
HCN54_RS16215	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HCN54_RS16220	ENOG4105BZU	Histidine kinase
HCN54_RS16230	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HCN54_RS16240	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HCN54_RS16245	ENOG4105D1F	ATP-binding protein
HCN54_RS16285	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HCN54_RS16290	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HCN54_RS16295	ENOG4105K5M	30s ribosomal protein S16
HCN54_RS16320	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS16340	ENOG4105C1J	atp-dependent rna helicase
HCN54_RS16350	ENOG4105CBG	Sulfatase
HCN54_RS16360	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HCN54_RS16435	ENOG4105DY9	regulatoR
HCN54_RS16450	ENOG4105DY9	regulatoR
HCN54_RS16455	ENOG4108HRK	Histidine kinase
HCN54_RS16485	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HCN54_RS16500	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HCN54_RS16510	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HCN54_RS16515	ENOG4105DYC	esterase
HCN54_RS16545	ENOG4108IGT	Dipeptidase
HCN54_RS16575	ENOG4105C2C	drug resistance transporter, Bcr CflA
HCN54_RS16580	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HCN54_RS16585	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS16590	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HCN54_RS16600	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HCN54_RS16610	ENOG4105D4P	Coproporphyrinogen iii oxidase
HCN54_RS16635	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HCN54_RS16640	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HCN54_RS16650	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HCN54_RS16670	ENOG4105C27	TonB-dependent Receptor Plug
HCN54_RS16680	ENOG4105G6Z	alkaline phosphatase
HCN54_RS16685	ENOG4105G6Z	alkaline phosphatase
HCN54_RS16700	ENOG4105BZU	Histidine kinase
HCN54_RS16715	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS16720	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS16730	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS16735	ENOG4107RBB	ABC transporter, permease
HCN54_RS16740	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN54_RS16745	ENOG4105DFG	type I secretion outer membrane protein
HCN54_RS16760	ENOG4105EUB	pirin domain protein
HCN54_RS16770	ENOG4105D85	methylase
HCN54_RS16775	ENOG4105CB5	ATP-dependent DNA helicase recG
HCN54_RS16780	ENOG4105F6A	helicase
HCN54_RS16785	ENOG4105ECI	YeeC-like protein
HCN54_RS16845	ENOG4108MYR	Secreted protein
HCN54_RS16855	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN54_RS16870	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HCN54_RS16880	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HCN54_RS16895	ENOG4105C0B	DNA polymerase III (alpha subunit)
HCN54_RS16930	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HCN54_RS16955	ENOG4105UYK	outer membrane protein a
HCN54_RS16975	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HCN54_RS17020	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HCN54_RS17050	ENOG41067HS	methyltransferase
HCN54_RS17055	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HCN54_RS17065	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HCN54_RS17075	ENOG4105D9N	nucleoside
HCN54_RS17085	ENOG4105C10	Electron transfer flavoprotein
HCN54_RS17090	ENOG4105BZJ	Electron transfer flavoprotein
HCN54_RS17095	ENOG4105CPP	Dehydrogenase, E1 component
HCN54_RS17105	ENOG4105F0N	pyrophosphate phospho-hydrolase
HCN54_RS17110	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HCN54_RS17120	ENOG4108Q6X	Aspartoacylase (EC 3.5.1.15)
HCN54_RS17125	ENOG4105D7Z	glutathione synthase
HCN54_RS17135	ENOG4105ZMH	deoxynucleoside kinase
HCN54_RS17175	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HCN54_RS17180	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HCN54_RS17185	ENOG4105CFH	Aspartokinase
HCN54_RS17190	ENOG4108UKZ	OsmC family
HCN54_RS17195	ENOG4105C28	cystathionine
HCN54_RS17200	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
HCN54_RS17210	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HCN54_RS17215	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HCN54_RS17225	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HCN54_RS17235	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HCN54_RS17240	ENOG4105CAY	ferredoxin--nadp reductase
HCN54_RS17260	ENOG4105C3R	Methionine synthase
HCN54_RS17265	ENOG4105C3R	Methionine synthase
HCN54_RS17270	ENOG4105SYT	Methylenetetrahydrofolate reductase
HCN54_RS17280	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HCN54_RS17305	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HCN54_RS17310	ENOG4105CSA	Coproporphyrinogen iii oxidase
HCN54_RS17335	ENOG4105UNS	Pfam:DUF419
HCN54_RS17340	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HCN54_RS17370	ENOG41075H3	AraC family transcriptional regulator
HCN54_RS17375	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HCN54_RS17390	ENOG4105CTU	Proline racemase
HCN54_RS17400	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HCN54_RS17425	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA